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MEFAYTARLAELKNRARTLAEKIMPFEDECERNNGLSAQSHASIKASVLEAGLQAINTPSEYGGAGLSVL EQVVVQDELGKLTNALWDAVWRPANPLAHATAEQRERYLIPAARGDRRDAVAISEAGAGSDFSSATTTAT PDGKGGYIINGQKWFVTVGDVADFLIVLAYIEPEHAPTMFLIDVATPGVKITDVPRYTHTFVYEHPEFTF TDVHVGPEAVLGGVGAGLELTRDWFTEERLMIGARTIGAAERALTLAVEWAKDRVQGGQPLINRQLIQGM IADSVVDITTNRAYTHQVAWEFDHADPTNADQRKTLHAKAATVKLAASEASNRVVDRCVQIFGGRGYIRD YPVERLWRELRVDRIWEGTSEIQRLVIANETNKRGLSALLSFPSAGTDQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4076 | - | - | 100% (399) | butyryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0667 | - | 1e-78 | 41.15% (384) | butyryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2205 | - | 1e-41 | 34.20% (345) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3302c | fadE25 | 4e-35 | 28.19% (376) | acyl-CoA dehydrogenase FADE25 |
| M. gilvum PYR-GCK | Mflv_4370 | - | 4e-41 | 32.90% (389) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0975c | fadE13 | 9e-37 | 30.05% (376) | acyl-CoA dehydrogenase FADE13 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 6e-35 | 28.72% (376) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1073c | - | 1e-38 | 31.89% (370) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4034 | fadE | 5e-39 | 33.33% (345) | acyl-CoA dehydrogenase FadE |
| M. avium 104 | MAV_2606 | - | 2e-51 | 36.12% (371) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3736 | - | 3e-42 | 33.62% (348) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_2626 | fadE25 | 2e-35 | 28.46% (376) | acyl-CoA dehydrogenase FadE25 |
| M. vanbaalenii PYR-1 | Mvan_1974 | - | 9e-41 | 32.64% (383) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4034|M.marinum_M -----------------------MTAPQVSDEDFAQILAQTRHFVRSVVL
TH_3736|M.thermoresistible__bu MYDIRRPGGVAIAPPGRTHKEKPMSTAEVSDEDFRQILRQTREFVRTAVV
Mflv_4370|M.gilvum_PYR-GCK -----------MASPPANAAEAGIPSAEVNDEDFQAILAATREFVRTAVV
Mvan_1974|M.vanbaalenii_PYR-1 -----------------------MSTAEVGDEDFRQILAQTRQFVRTAVV
Rv0975c|M.tuberculosis_H37Rv -------------------------MNIWTTPERQQLRKTVRAFAEREIL
MAB_1073c|M.abscessus_ATCC_199 ----------------------MTAVNSWNTPERKALRETVRDFAEREIL
Mb3302c|M.bovis_AF2122/97 ---------------MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIA
MLBr_00737|M.leprae_Br4923 ---------------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIA
MUL_2626|M.ulcerans_Agy99 ---------------MAGWAGNPSFDLFQLPEEHQELRAAIRALAEKEIA
MSMEG_4076|M.smegmatis_MC2_155 --------------------------MEFAYTARLAELKNRARTLAEKIM
MAV_2606|M.avium_104 ----------------------------------MMLRDTVRRFMDAHVH
:
MMAR_4034|M.marinum_M PREQQILDE-----DRVPEDLRDQAKQMGLFGYAIPPQWGGLGLNLVQDV
TH_3736|M.thermoresistible__bu PRELEILNE-----DRVPDDLREQAKQMGLFGYAIPQQWGGLGLDLAQDV
Mflv_4370|M.gilvum_PYR-GCK PREQEILST-----DQVPDDLREQTKSMGLFGYAIPQEWGGLGLNLAQDV
Mvan_1974|M.vanbaalenii_PYR-1 PREQEILTT-----DRVPDELREQAKSMGLFGYAIPQEWGGLGLDLTQDV
Rv0975c|M.tuberculosis_H37Rv PHVDEWERI-----GELPRGLHRLAGAAGLLGAGFPEAVGGGGGDGADPV
MAB_1073c|M.abscessus_ATCC_199 PNVNEWERE-----GLLPRELHRKAGDLGLLGPGSPEAVGGGGGDAIDPV
Mb3302c|M.bovis_AF2122/97 PHAAEVDEK-----ARFPEEALVALNSSGFNAVHIPEEYGGQGADSVATC
MLBr_00737|M.leprae_Br4923 PHAADVDQR-----ARFPEEALAALNASGFNAIHVPEEYGGQGADSVAAC
MUL_2626|M.ulcerans_Agy99 PHAADVDEN-----SRFPQEALDALNASGFNALHVPEEYGGQGADSVAAC
MSMEG_4076|M.smegmatis_MC2_155 PFEDECERN-NGLSAQSHASIKASVLEAGLQAINTPSEYGGAGLSVLEQV
MAV_2606|M.avium_104 PVEEKLDHDTVGLPREQLVALQAKAREAGLWSLQTPEEYGGAGLSVLGQV
* . *: . * ** * .
MMAR_4034|M.marinum_M ELAMELGYTSLAVRSMFGTN-NGIAGQVLVGFGTDEQKARWLEPIASGDV
TH_3736|M.thermoresistible__bu ELAMELGYTSLALRSMFGTN-NGIAGQVLVGFGTEEQKARWLEPIASGEV
Mflv_4370|M.gilvum_PYR-GCK ELAMELGYTSLALRSMFGTN-NGIAGQVLVGYGTDEQKKTWLERIASGEI
Mvan_1974|M.vanbaalenii_PYR-1 ELAMELGYTSLALRSMFGTN-NGIAGQVLVGYGTDEQKSTWLERIASGEV
Rv0975c|M.tuberculosis_H37Rv IICEEMHQAGAPGGVYASLFTCGIAVPHMVASGDERLIATYVRPTLAGEK
MAB_1073c|M.abscessus_ATCC_199 IVCEELHYAGVPGGVFASLFTCGISTPHMIASGDQRLIDNYVKPTLAGEL
Mb3302c|M.bovis_AF2122/97 IVIEEVARVDASASLIPAVN--KLGTMGLILRGSEELKKQVLPALAAEGA
MLBr_00737|M.leprae_Br4923 IVIEEVARVDASASLIPAVN--KLGTMGLILRGSEELKKQVLPSLAAEGA
MUL_2626|M.ulcerans_Agy99 IVIEEVARVDASASLIPAVN--KLGTMGLILRGSDELKKQVLPSLADGAA
MSMEG_4076|M.smegmatis_MC2_155 VVQDELGKLTN-----ALWDAVWRPANPLAHATAEQRERYLIPAARGDR-
MAV_2606|M.avium_104 VVAEEAAKCRMGAFFPALGAFGGNPPNIMFKATPEQFEKYARPVIDGIMS
: * : :.
MMAR_4034|M.marinum_M VASFALTEPGAGSSPAGLRTKAVRDGD----DWLITGQKRFITNAPVADL
TH_3736|M.thermoresistible__bu VASFALTEPGAGSNPAGLRSRAVRDGSGADADWIINGQKRFITNAPVADL
Mflv_4370|M.gilvum_PYR-GCK VASFALTEPGAGSNPSGLRTKAVRDGDGPHSGWILNGQKRFITNAPNADL
Mvan_1974|M.vanbaalenii_PYR-1 VASFALTEPGAGSNPSGLRTKAVRDGDGSCSGWIINGQKRFITNAPNANL
Rv0975c|M.tuberculosis_H37Rv IGALAITEPGGGSDVGHLRTSAVRDGD----HYVINGAKTYITSGVRADY
MAB_1073c|M.abscessus_ATCC_199 IGSLAITEPGGGSDVGHLTTSAKRDGD----HYIVNGAKTFITSGVRADY
Mb3302c|M.bovis_AF2122/97 MASYALSEREAGSDAASMRTRAKADGD----HWILNGAKCWITNGGKSTW
MLBr_00737|M.leprae_Br4923 MASYALSEREAGSDAASMRTRAKADGD----DWILNGFKCWITNGGKSTW
MUL_2626|M.ulcerans_Agy99 MASYALSEREAGSDAGAMRTRAKADGD----DWILNGTKCWITNGGKSSW
MSMEG_4076|M.smegmatis_MC2_155 RDAVAISEAGAGSDFSSATTTATPDGKG---GYIINGQKWFVTVGDVADF
MAV_2606|M.avium_104 KAYTAITEASGGSDPARAIKLKATRDGS---SYLLNGSKMWISHAPDADW
*::* .**. . . . :::.* * ::: . :
MMAR_4034|M.marinum_M FVVFARTRPASDKSPGIAVFLVPAQSAGVEVGAKDAKMGQEGAWTADVSF
TH_3736|M.thermoresistible__bu FVVFARSRPADERGAGIAVFLVPADAPGVEVGAKDAKMGQEGAWTADVTF
Mflv_4370|M.gilvum_PYR-GCK FVTFARSRPADDKGAGIAVFLVPADTPGVDIGAKDKKMGQEGAWTADVNF
Mvan_1974|M.vanbaalenii_PYR-1 FVTFARSRPADDKGAGIAVFLVPADTPGVEVGAKDKKMGQEGAWTADVNF
Rv0975c|M.tuberculosis_H37Rv VVTAVRTGGPG--AAGVSLLVVEKDTPGFEVTRKLDKMGWRSSDTAELCY
MAB_1073c|M.abscessus_ATCC_199 VVTAVRTGGPG--AAGVSLLLIDKDTPGFEVARKLDKMGWRSSDTAELSF
Mb3302c|M.bovis_AF2122/97 YTVMAVTDPDRG-ANGISAFMVHKDDEGFTVGPKERKLGIKGSPTTELYF
MLBr_00737|M.leprae_Br4923 YTVMAVTDPDKG-ANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYF
MUL_2626|M.ulcerans_Agy99 YTVMAVTDPENG-ANGISAFVVHKDDEGFVVGPKERKLGIKGSPTTELYF
MSMEG_4076|M.smegmatis_MC2_155 LIVLAY---IEP-EHAPTMFLIDVATPGVKITDVPRYTHTFVYEHPEFTF
MAV_2606|M.avium_104 GVVYAR---TGEGRHGISAFILEKGTPGVTFSRIPVMAS---FAPYELHF
. . . : ::: *. . :. :
MMAR_4034|M.marinum_M TDVRVDDAALVGGSEDIGYRAAMTSLARGRVHIAAIAVGAAQRALDESVA
TH_3736|M.thermoresistible__bu TDVRVPASALVGGEEDIGYRAAMTSLARGRVHIAALAVGTAQRALDESVA
Mflv_4370|M.gilvum_PYR-GCK TDVEVPDTALVGGSEDLGYRAAMTSLARGRVHIAALAVGAAQRALDESVA
Mvan_1974|M.vanbaalenii_PYR-1 TDVRVPDAALVGGSEDIGYRAAMTSLARGRVHIAALAVGAAQRALDESVT
Rv0975c|M.tuberculosis_H37Rv TDVAVPATNLVG-AENSGFTQIARAFVSERIGLAAQAYSSAQRCLDLTAQ
MAB_1073c|M.abscessus_ATCC_199 TDVRVPAENLVG-SENTGFAQIAGAFVSERIGLAAQAYASAQRCLDLTVE
Mb3302c|M.bovis_AF2122/97 ENCRIPGDRIIG-EPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIA
MLBr_00737|M.leprae_Br4923 DKCRIPGDRIIG-EPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIV
MUL_2626|M.ulcerans_Agy99 ENCRVPGDRMIG-EPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIA
MSMEG_4076|M.smegmatis_MC2_155 TDVHVGPEAVLG-GVGAGLELTRDWFTEERLMIGARTIGAAERALTLAVE
MAV_2606|M.avium_104 DNVRLPAEQLIG-EEGQGFSLAGEFLVHGRIVYAAGPIGIAQSALDMACR
. : ::* . * : * .* . . *: .* :
MMAR_4034|M.marinum_M YASTATQGGVTIGSFQLVQAMLADQQTGVLAGRALVRDAAR-------MW
TH_3736|M.thermoresistible__bu YAASATQGGTPIGQFQLVQAMLADQQTGVMAGRALVRDAAR-------KW
Mflv_4370|M.gilvum_PYR-GCK YAATATQGGTPIGDFQLVQAMLADQQTGVMAGRALVRDAAR-------LW
Mvan_1974|M.vanbaalenii_PYR-1 YAATATQGGTAIGDFQLVQAMLADQQTGVMAGRALVRETAR-------QW
Rv0975c|M.tuberculosis_H37Rv WCRDRETFGRPLISRQSVQNTLAEMARRIDVARVYAHHVVE-------RQ
MAB_1073c|M.abscessus_ATCC_199 WCRNRETFGRPLISRQSVQNTLAEMARRIDVARVYTHALVD-------RA
Mb3302c|M.bovis_AF2122/97 YTKDRKQFGESISTFQAVQFMLADMAMKVEAARLMVYSAAA-------RA
MLBr_00737|M.leprae_Br4923 YTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAA-------RA
MUL_2626|M.ulcerans_Agy99 YTKDRKQFGKSISDFQAVQFMLADMAMKVESARLMVYSAAA-------RA
MSMEG_4076|M.smegmatis_MC2_155 WAKDRVQGGQPLINRQLIQGMIADSVVDITTNRAYTHQVAWEFDHADPTN
MAV_2606|M.avium_104 WARDRDVFGGRLADKQGIQWMLVDSEVDLRAARLLMYQAA--------SN
: * : * :* :.: : * .
MMAR_4034|M.marinum_M VSGADRRIAPS-AAKLFCTEMAGKVADLAVQIHGGSGYMRGVPVERIYRD
TH_3736|M.thermoresistible__bu VSGEDRRVAPS-AAKLFCTEMAGQVADLAVQIHGGTGYMREVPVERIYRD
Mflv_4370|M.gilvum_PYR-GCK VTGQDRRIAPS-AAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRD
Mvan_1974|M.vanbaalenii_PYR-1 VTGEDRRIAPS-AAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRD
Rv0975c|M.tuberculosis_H37Rv LAGETDLIAQVCFAKNTAVQAGEWVANQAVQLFGGMGYMAESEVERQYRD
MAB_1073c|M.abscessus_ATCC_199 IAGESNLIAEVCFAKNTAVEAGEWVANQGVQLFGGMGYMAESEIERQYRD
Mb3302c|M.bovis_AF2122/97 ERGEPDLGFISAASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERFMRD
MLBr_00737|M.leprae_Br4923 ERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRD
MUL_2626|M.ulcerans_Agy99 ERGESNLGFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMMRD
MSMEG_4076|M.smegmatis_MC2_155 ADQRKTLHAKAATVKLAASEASNRVVDRCVQIFGGRGYIRDYPVERLWRE
MAV_2606|M.avium_104 ADLGRDVRVDASVAKMFGTEAAYRVLDRCIQIHGALGISTELPLERWFRD
* : . * :*:.*. * :** *:
MMAR_4034|M.marinum_M VRLLRLYEGTSEIQQLIIGSNLIKAANR------------
TH_3736|M.thermoresistible__bu VRLLRLYEGTSEIQRLIIGGGLVKAAQRQTN---------
Mflv_4370|M.gilvum_PYR-GCK VRLLRLYEGTSEIQKLIIGGGLVKGAKGK-----------
Mvan_1974|M.vanbaalenii_PYR-1 VRLLRLYEGTSEIQRLIIGGGLVKGAKAR-----------
Rv0975c|M.tuberculosis_H37Rv MRILGIGGGTTEILTALAAKTLGYQS--------------
MAB_1073c|M.abscessus_ATCC_199 MRIIGIGGGTTEILTSLAAKLLGFQS--------------
Mb3302c|M.bovis_AF2122/97 AKITQIYEGTNQIQRVVMSRALLR----------------
MLBr_00737|M.leprae_Br4923 AKITQIYEGTNQIQRVVMSRALLR----------------
MUL_2626|M.ulcerans_Agy99 AKITQIYEGTNQIQRVVMSRALLR----------------
MSMEG_4076|M.smegmatis_MC2_155 LRVDRIWEGTSEIQRLVIANETNKRGLSALLSFPSAGTDQ
MAV_2606|M.avium_104 LRVKRLGEGATEVQREIIARSLVR----------------
:: : *:.:: : .