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M. smegmatis MC2 155 MSMEG_0527 (-)

annotation: 2-hydroxycyclohexnecarboxyl-CoA dehydrogenase
coordinates: 605757 - 606500
length: 247

VSRVAAVTGAGSGVGRATALQLARDGHRVAVMDLDGQAAEEAAAKIESHGGRALAVAVDVADESAVAAGF
EAARQAFGPIGIVVTSAAMGGFTRFDKITLDEWNRYLAVNLTGTFLCIRAALPDMVKAQWGRIVTISSAA
GQRGAPAQGHYSATKGGVIAMTKTLALDYAAKGITANTIPPFVIDTPMLREQQAAGLLPQAEHLTKAIPA
GRLGSGDDVAAMCSFLCSDAAGYVTGQVIGVNGGAVL

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. smegmatis MC2 155 MSMEG_0527 - - 100% (247) 2-hydroxycyclohexnecarboxyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_0294 fabG 6e-68 51.01% (247) 3-oxoacyl-(acyl-carrier-protein) reductase
M. smegmatis MC2 155 MSMEG_6538 - 1e-55 45.27% (243) 3-oxoacyl-(acyl-carrier-protein) reductase, putative

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0792 - 8e-37 36.55% (249) short chain dehydrogenase
M. gilvum PYR-GCK Mflv_1258 - 1e-101 73.68% (247) short-chain dehydrogenase/reductase SDR
M. tuberculosis H37Rv Rv0769 - 3e-37 36.95% (249) short chain dehydrogenase
M. leprae Br4923 MLBr_01807 fabG1 4e-38 35.66% (244) 3-oxoacyl-
M. abscessus ATCC 19977 MAB_2723c - 6e-36 34.84% (244) 3-oxoacyl-
M. marinum M MMAR_4715 - 5e-55 46.28% (242) 3-oxoacyl-
M. avium 104 MAV_1395 - 1e-91 63.52% (244) 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase
M. thermoresistible (build 8) TH_2435 - 2e-99 72.92% (240) PUTATIVE short-chain dehydrogenase/reductase SDR
M. ulcerans Agy99 MUL_0315 fabG2 9e-55 46.67% (240) 3-oxoacyl-
M. vanbaalenii PYR-1 Mvan_4185 - 2e-70 51.01% (247) short-chain dehydrogenase/reductase SDR

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_0527|M.smegmatis_MC2_155      -MSR-------------------VAAVTGAGSGVGRATALQLARDGHRVA
Mflv_1258|M.gilvum_PYR-GCK          MVSR-------------------VAVVTGGASGLGEAICAGLAADGHRVA
TH_2435|M.thermoresistible__bu      --------------------------VTGGASGLGRAIAARLGDDGHRVA
MAV_1395|M.avium_104                -----------------------MAVVTGGGSGIGRAIVERLAHDGHRVA
MMAR_4715|M.marinum_M               -MK--------------------TAVVTGGASGIGLAIARRLRADGIDVA
MUL_0315|M.ulcerans_Agy99           -MRPDSS----------PSWCTITSVVTGGASGIGLAIARRLSADGTDVA
Mvan_4185|M.vanbaalenii_PYR-1       -MTR-------------------VAVVTGGASGMGEATCHELGRRGCKVA
MLBr_01807|M.leprae_Br4923          -MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVA
MAB_2723c|M.abscessus_ATCC_199      -MTNA-------------EFVPRSVLVTGGNRGIGLAVAQRLAADGHKVA
Mb0792|M.bovis_AF2122/97            ------------------MFDSKVAIVTGAAQGIGQAYAQALAREGASVV
Rv0769|M.tuberculosis_H37Rv         ------------------MFDSKVAIVTGAAQGIGQAYAQALAREGASVV
                                                              ***.  *:* *    *   *  *.

MSMEG_0527|M.smegmatis_MC2_155      VMDLDGQAAEEAAAKIESHGGRALAVAVDVADESAVAAGFEAARQAFGPI
Mflv_1258|M.gilvum_PYR-GCK          VLDLDADAANRVAASLRGNGASAVGVAVDVSDEDAVVRAFDAVRTEFGPV
TH_2435|M.thermoresistible__bu      VLDIDHAAAEQTAAELRAHGGDAVAVGADVADQDAVHDAFAAIRGSLGPV
MAV_1395|M.avium_104                VLDVNEEAAEKVAARVAADGAHAIAVPTDVAESASVAAAFESVRRALGSV
MMAR_4715|M.marinum_M               TLDLKTPDGE-------------LAFSADVTNRSQVDAALTAIRQRLGPV
MUL_0315|M.ulcerans_Agy99           TLDLKTPDGG-------------LAFSADVTNRSQVDAALAAIRQRLGPV
Mvan_4185|M.vanbaalenii_PYR-1       VLDLDGQAAQRVAEELRGDGVPALGVAADVTDRAAVEDAFAKVRTELGPV
MLBr_01807|M.leprae_Br4923          VTHRASVVPDW-----------FFGVECDVTDNDAIGAAFKAVEEHQGPV
MAB_2723c|M.abscessus_ATCC_199      VTHRGSGAPEG-----------LLGVQCDITDNDQIDAAFKEVEEKQGPV
Mb0792|M.bovis_AF2122/97            VADINADGAAAVAKQIVADGGTVIHVPVDVSDEDSAKAMVDRAVGAFGGI
Rv0769|M.tuberculosis_H37Rv         VADINADGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFGGI
                                    . .                    . .  *:::       .       * :

MSMEG_0527|M.smegmatis_MC2_155      GIVVTSAAMGG---FTRFDKITLDEWNRYLAVNLTGTFLCIRAALPDMVK
Mflv_1258|M.gilvum_PYR-GCK          EILVTSAAIGG---FTRFDKITLDEWNRYLAVNLTGTFLSIRAALSDMVA
TH_2435|M.thermoresistible__bu      HILVTSAAIAG---FTRFDEITLDEWNRYLAVNLTGTFLCVQAALTDMVA
MAV_1395|M.avium_104                QVLVTSAAITG---FKPFAEITIEDWNRHLAVNLTGTFLCLQAALPDMVE
MMAR_4715|M.marinum_M               TILVNAAGLDG---FKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVA
MUL_0315|M.ulcerans_Agy99           TILVNAAGLDG---FKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVA
Mvan_4185|M.vanbaalenii_PYR-1       HILVTSAGLVD---FAPFLEISPDRWQRLIEVNLNGTFHCAQVAIPDMLA
MLBr_01807|M.leprae_Br4923          EVLVANAGITS---DMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIK
MAB_2723c|M.abscessus_ATCC_199      EVLVANAGITA---DMLIMRMSEEQFLKVIDANLIGTFRLAKRASRNMIK
Mb0792|M.bovis_AF2122/97            DYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHMAK
Rv0769|M.tuberculosis_H37Rv         DYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHMAK
                                      :*  *.:        :  :. : : : : .*  *.:   : .  .*  

MSMEG_0527|M.smegmatis_MC2_155      AQWGRIVTISSAAGQRGAPAQGHYSATKGGVIAMTKTLALDYAAKGITAN
Mflv_1258|M.gilvum_PYR-GCK          AQWGRVVTISSAAGQQGAPRQGHYSATKGGVIAMTKTVARDYARHGITAN
TH_2435|M.thermoresistible__bu      DGWGRIVTISSAAGQQGAHRQGHYAATKGGVIALTKTVALDYAAKGITAN
MAV_1395|M.avium_104                AGWGRVVTISSTAAQTGSPRQGHYSASKGGVIALTRTIALEYAAHGITAN
MMAR_4715|M.marinum_M               AGWGRIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVN
MUL_0315|M.ulcerans_Agy99           AGWGRIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVN
Mvan_4185|M.vanbaalenii_PYR-1       AGWGRIVMISSSSAQRGSPGMAHYAASKGALISFTRSLAREYGPAGITVN
MLBr_01807|M.leprae_Br4923          QRFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITAN
MAB_2723c|M.abscessus_ATCC_199      KRFGRLIFMGSVAGQIGLPGQANYSASKAGLVGMARALTRELGSRSITAN
Mb0792|M.bovis_AF2122/97            RGGGAIVNQSSTAAWLYSN---FYGLAKVGVNGLTQQLARELGGMKIRIN
Rv0769|M.tuberculosis_H37Rv         RGGGAIVNQSSTAAWLYSN---FYGLAKVGVNGLTQQLARELGGMKIRIN
                                       *  :  .*            *  :* .: .::: :: : .   *  *

MSMEG_0527|M.smegmatis_MC2_155      TIPPFVIDTPMLREQQAAGLLPQAEHLTKAIPAGRLGSGDDVAAMCSFLC
Mflv_1258|M.gilvum_PYR-GCK          SLPPFAIETPMLRRQQSEGKLPPDEFLTQAIPAGRVGAPSDVAAVCSFLC
TH_2435|M.thermoresistible__bu      TVPPFVIDSPMLREQQRRGTLPPAEYLTRAIPMGRLGVAEDVAAVCSFLC
MAV_1395|M.avium_104                TVPPFSVDTPMLRAAQEAGNLPPVKYLAKASPVGRLGTGEDIAAACAFLC
MMAR_4715|M.marinum_M               AVPPGFIDTPMLRNAAAQGHLGDIEQNIARTPVRRIGKPEDIAAACAFLV
MUL_0315|M.ulcerans_Agy99           AVPPGFIDTPMLRNAAAQGHLGDIEQNIARTPVRRIGKPEDIAAACAFLV
Mvan_4185|M.vanbaalenii_PYR-1       NVPPSGIETPMQHQSQAAGFLPPNEQMAASIPVGHLGTGDDIAAAVGFLC
MLBr_01807|M.leprae_Br4923          VVAPGFIDTEMTRAMDSK----YQEAALQAIPLGRIGAVEEIAGAVSFLA
MAB_2723c|M.abscessus_ATCC_199      VVAPGFIDTDMTRELGEK----HVETALTAIPMGRIGEPSEVAGVVSWLA
Mb0792|M.bovis_AF2122/97            AIAPGPIDTEATRTVTPA---ELVKNMVQTIPLSRMGTPEDLVGMCLFLL
Rv0769|M.tuberculosis_H37Rv         AIAPGPIDTEATRTVTPA---ELVKNMVQTIPLSRMGTPEDLVGMCLFLL
                                     :.*  :::   :           :      *  ::*  .::..   :* 

MSMEG_0527|M.smegmatis_MC2_155      SDAAGYVTGQVIGVNGGAVL--
Mflv_1258|M.gilvum_PYR-GCK          SDAAGYVTGQVIGVNGGAVL--
TH_2435|M.thermoresistible__bu      SDAAGYLTGQVIGVNGGAIR--
MAV_1395|M.avium_104                SDEAGYITGQIIGVNGGEVI--
MMAR_4715|M.marinum_M               SEEAGYITGQILGVNGGRNT--
MUL_0315|M.ulcerans_Agy99           SEEAGYITGQILGVNGGRNT--
Mvan_4185|M.vanbaalenii_PYR-1       SEEAGFITGQTLGVNGGSVMA-
MLBr_01807|M.leprae_Br4923          SEDAGYISGAVIPVDGGLGMGH
MAB_2723c|M.abscessus_ATCC_199      SPDAAYVSGAVIPVDGGLGMGH
Mb0792|M.bovis_AF2122/97            SDSASWITGQIFNVDGGQIIRS
Rv0769|M.tuberculosis_H37Rv         SDSASWITGQIFNVDGGQIIRS
                                    *  *.:::*  : *:**

species	id	gene	e-value	identity (len)	annotation
M. smegmatis MC2 155	MSMEG_0527	-	-	100% (247)	2-hydroxycyclohexnecarboxyl-CoA dehydrogenase
M. smegmatis MC2 155	MSMEG_0294	fabG	6e-68	51.01% (247)	3-oxoacyl-(acyl-carrier-protein) reductase
M. smegmatis MC2 155	MSMEG_6538	-	1e-55	45.27% (243)	3-oxoacyl-(acyl-carrier-protein) reductase, putative