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DEATPARQLLTDRVAVVTGGAGGIGAATSRLFAQHGAQVVIADIDAELAHRTVDEIGGAAWVVGTDVRDA DQVSALAQRVLDRYGRVDILVNNVGHWLRHPGNFVDTDPQLWDELYRVNLHHVLLATHAFLPAMIEQHGG AIVNVSSVEGLRGYPEDPVYAAFKAAVIHFTRSLAVQVGNHGVRINAIAPDVTESLQVPYSQWLSDAEQT QWPGWVPVGRMGVPEDQARVILFLACELSAFVTGHTIPTDGGTAAAGGWFRSSRRPDREWTNRPIAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2592 | - | - | 100% (278) | short chain dehydrogenase |
| M. marinum M | MMAR_4756 | - | 5e-46 | 41.47% (258) | oxidoreductase |
| M. marinum M | MMAR_0271 | - | 1e-35 | 37.85% (251) | short-chain type dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1385 | fabG | 2e-33 | 34.54% (249) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_2424 | - | 2e-42 | 40.00% (255) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1350 | fabG | 2e-33 | 34.54% (249) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 4e-25 | 36.08% (194) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0833 | - | 1e-29 | 32.13% (249) | Short-chain dehydrogenase/reductase |
| M. avium 104 | MAV_3012 | - | 1e-127 | 79.41% (272) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_4850 | - | 1e-44 | 41.38% (261) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3505 | - | 7e-49 | 43.35% (263) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3168 | - | 1e-154 | 98.86% (264) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4228 | - | 1e-44 | 40.15% (259) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2592|M.marinum_M --------------------------------------------------
MUL_3168|M.ulcerans_Agy99 --------------------------------------------------
MAV_3012|M.avium_104 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2424|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4228|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4850|M.smegmatis_MC2_155 --------------------------------------------------
TH_3505|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MMAR_2592|M.marinum_M --------------------------------------------------
MUL_3168|M.ulcerans_Agy99 --------------------------------------------------
MAV_3012|M.avium_104 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2424|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4228|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4850|M.smegmatis_MC2_155 --------------------------------------------------
TH_3505|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MMAR_2592|M.marinum_M --------------------------------------------------
MUL_3168|M.ulcerans_Agy99 --------------------------------------------------
MAV_3012|M.avium_104 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2424|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4228|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4850|M.smegmatis_MC2_155 --------------------------------------------------
TH_3505|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MMAR_2592|M.marinum_M --------------------------------------------------
MUL_3168|M.ulcerans_Agy99 --------------------------------------------------
MAV_3012|M.avium_104 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2424|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4228|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4850|M.smegmatis_MC2_155 --------------------------------------------------
TH_3505|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MMAR_2592|M.marinum_M --------------------------------------------------
MUL_3168|M.ulcerans_Agy99 --------------------------------------------------
MAV_3012|M.avium_104 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2424|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4228|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4850|M.smegmatis_MC2_155 --------------------------------------------------
TH_3505|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MMAR_2592|M.marinum_M --------------------------------------------------
MUL_3168|M.ulcerans_Agy99 --------------------------------------------------
MAV_3012|M.avium_104 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2424|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4228|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4850|M.smegmatis_MC2_155 --------------------------------------------------
TH_3505|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MMAR_2592|M.marinum_M ---------------MDEATPARQLLTDRVAVVTGGAGGIGAATSRLFAQ
MUL_3168|M.ulcerans_Agy99 -----------------------------MAVVAGGAGGIGAATSRLFAQ
MAV_3012|M.avium_104 ---------------MTQHKHFDPLLSDRVAVVTGGGGGIGAATARLFAE
Mb1385|M.bovis_AF2122/97 ---------------------MASLLNARTAVITGGAQGLGLAIGQRFVA
Rv1350|M.tuberculosis_H37Rv ---------------------MASLLNARTAVITGGAQGLGLAIGQRFVA
MAB_0833|M.abscessus_ATCC_1997 --------------MNRETFSRLFDLTGRTAIVTGGTRGIGRALAEGYAC
Mflv_2424|M.gilvum_PYR-GCK ----------------MAITASDILLTGRVAVVTGGGAGIGRGIAQGLAA
Mvan_4228|M.vanbaalenii_PYR-1 ----------------MTIAPSDILLTGRVAVVTGGGAGIGKGIAHGLAA
MSMEG_4850|M.smegmatis_MC2_155 ----------------MAINPSDILLTGRVAVVTGGGAGIGRGIAEGLAA
TH_3505|M.thermoresistible__bu ----------------LTIAPADILLTDRVAVVTGGGAGLGRGIAAGFAA
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
. ::*. *:* . .
MMAR_2592|M.marinum_M HGAQVVIADIDAELAHR---TVDEIGGAAWVVGTDVRDADQVSALAQRVL
MUL_3168|M.ulcerans_Agy99 HGAQVVIADIDAELAHR---TVDEIGGAAWVVGTDVRDADQVSALAQRVL
MAV_3012|M.avium_104 HGAHVVIADIDAELADETASTIAASGGSAHPITADVRNAAEVTHFARTVL
Mb1385|M.bovis_AF2122/97 EGARVVLGDVNLEATEVAAKRLGGD-DVALAVRCDVTQADDVDILIRTAV
Rv1350|M.tuberculosis_H37Rv EGARVVLGDVNLEATEVAAKRLGGD-DVALAVRCDVTQADDVDILIRTAV
MAB_0833|M.abscessus_ATCC_1997 AGANVVVASRKPEACTEAVERLRSLGARALGVPTHTGDIHSLEELVRATA
Mflv_2424|M.gilvum_PYR-GCK FGASVAIWERDPDTCAAAAAAIG-----GLGLEVDVRDAAAVDTALDRTE
Mvan_4228|M.vanbaalenii_PYR-1 FGASVAIWERDPQTCGEAAASVG-----ALGLPTDVRDAEAVQAALERTE
MSMEG_4850|M.smegmatis_MC2_155 FGARVAIWERDPETCEAAARAVG-----GVGIVTDVRDADQVDAALAQTT
TH_3505|M.thermoresistible__bu FGARVAIWERDPDSCARTAEEIG-----ALGIVTDVRDSAAVSAALRQTT
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
** *.: . . : . .. : : .
MMAR_2592|M.marinum_M DRYGRVDILVNNVGHWLRHPGNFVDTDPQLWDELYRVNLHHVLLATHAFL
MUL_3168|M.ulcerans_Agy99 DRYGRLDILVNNVGHWLRHPGNFVDTDPQLWDELYRVNLHHVLLATHAFL
MAV_3012|M.avium_104 DRYGRIDVLVNNVGHWLRHPGGFADTDPQLWDELYRINLHHVFLVTHAFL
Mb1385|M.bovis_AF2122/97 ERFGGLDVMVNNAGITRDAT--MRTMTEEQFDQVIAVHLKGTWNGTRLAA
Rv1350|M.tuberculosis_H37Rv ERFGGLDVMVNNAGITRDAT--MRTMTEEQFDQVIAVHLKGTWNGTRLAA
MAB_0833|M.abscessus_ATCC_1997 EEFGGIDIVVNNAANALTEP--VGAFTVDGWDKSFGVNLRGPVFLVQAAL
Mflv_2424|M.gilvum_PYR-GCK RELGTVSILVNNAGGTFNSP--LLDTSENGWDALYRSNLRHVLLCTQRVA
Mvan_4228|M.vanbaalenii_PYR-1 RELGTVSILVNNAGGTFNSP--LLETSENGWDALYRSNLRHVLLCTQRVA
MSMEG_4850|M.smegmatis_MC2_155 SELGTVSILVNNAGGVFASP--LLETTENGWDALYKANLRHVLLCTQRVA
TH_3505|M.thermoresistible__bu EQLGSPTILVNNAGGTFSSP--LLETSENGWDALYRANLRHVLLCTQQVG
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQAGR--FLDTPPEEFDRVLAVNLGGVVNCCRAFG
. * ::***.. . : :* :* :
MMAR_2592|M.marinum_M PAMIEQHG-GAIVNVSSVEGLRGYPEDPVYAAFKAAVIHFTRSLAVQVGN
MUL_3168|M.ulcerans_Agy99 PAMIEQHG-GAIVNVSSVEGLRGYPEDPVYAAFKAAVIHFTHSLAVQVGN
MAV_3012|M.avium_104 PTMIDRGA-GAIVNVSSVEGLRGYPEDPVYAAFKAAVIGFTRSLAVQVGN
Mb1385|M.bovis_AF2122/97 AIMRERKR-GAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAH
Rv1350|M.tuberculosis_H37Rv AIMRERKR-GAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAH
MAB_0833|M.abscessus_ATCC_1997 PHLVASPH-AAVLNVVSVGAFMFGQGVSMYSAAKAALVSYTRSAAAELAS
Mflv_2424|M.gilvum_PYR-GCK RRLVAAEQTGSVINVTSIEGSRAAPGYAAYAAAKAGVVNYTKTASFELAP
Mvan_4228|M.vanbaalenii_PYR-1 RRLVEVGQPGSVINITSIEGSRAAPGYAAYAAAKAGVVNYTKTASFELAP
MSMEG_4850|M.smegmatis_MC2_155 RDMVAAEMPGSIINLTSIEGVRAAPRYAAYSAAKAGVINYTLTAAFELAP
TH_3505|M.thermoresistible__bu RQLVAAGQPGSIVNITSIEGARAAPGYAAYAAAKAGVINYTRTAAFELAP
MLBr_00862|M.leprae_Br4923 QRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDA
: . ::*: *: . . *.: **. : ::
MMAR_2592|M.marinum_M HGVRINAIAPDVTESLQVPYSQWLSDAEQTQWPGWVPVGRMGVPEDQARV
MUL_3168|M.ulcerans_Agy99 HGVRINAIAPDVTESLQVPYSQWLSDAEQTQWPGWVPVGRMGVPEDQARV
MAV_3012|M.avium_104 HGVRVNAVAPDVTESLQVPYSQWLSAEEQSQWPRWVPVGRMGLPEDQARV
Mb1385|M.bovis_AF2122/97 LGIRVNAIAPGLIRSAMT--EAMP-QRIWDQKLAEVPMGRAGEPSEVASV
Rv1350|M.tuberculosis_H37Rv LGIRVNAIAPGLIRSAMT--EAMP-QRIWDQKLAEVPMGRAGEPSEVASV
MAB_0833|M.abscessus_ATCC_1997 RGVRVNALAPGAIDTDMV--RKTP-PAEVERMANTNHLKRLGLPDEMVGT
Mflv_2424|M.gilvum_PYR-GCK YGIRVNGLAPDLTMTEGL--QKLAFGELSGTVARMVPMRRAGHVDEMASA
Mvan_4228|M.vanbaalenii_PYR-1 HRIRVNALAPDLTMTEGL--QKLAFGDLSGTMADMVPMRRVGHVDEMASA
MSMEG_4850|M.smegmatis_MC2_155 YGIRVNALAPDLTVTDGL--LALSGGRQPG--GDAIPMKRPGHVDEMAGA
TH_3505|M.thermoresistible__bu HRIRVNAIAPDIAVTEGL--QRMSPDGIPPEVGHAIPLGRPGHVDEIAGA
MLBr_00862|M.leprae_Br4923 VGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDR-RGQLDMMFRLRRY
: :. :.*. : : .
MMAR_2592|M.marinum_M ILFLACELSAFVTGHTIPTDGGTAAAGGWFRSSRRPDREWTNRPIAP--
MUL_3168|M.ulcerans_Agy99 ILFLACELSAFVTGHTIPTDGGTAAAGGWFRSSRRPDREWTNRPIAP--
MAV_3012|M.avium_104 ILFLASDCSSFITGHTIPTDGGTTAAGGWFRSSRRPGREWTNRPADP--
Mb1385|M.bovis_AF2122/97 AVFLASDLSSYMTGTVLDVTGGRFI------------------------
Rv1350|M.tuberculosis_H37Rv AVFLASDLSSYMTGTVLDVTGGRFI------------------------
MAB_0833|M.abscessus_ATCC_1997 ALLLTSDAGSYITGQTIIADGGLVAR-----------------------
Mflv_2424|M.gilvum_PYR-GCK AVFLASDMASYITGQTIHVDGGTEAAGGWYFHPDNGAPTLGPA------
Mvan_4228|M.vanbaalenii_PYR-1 AVFLASDMAAYITGQTIHVDGGTAAAGGWYFHPETGVPTLGPA------
MSMEG_4850|M.smegmatis_MC2_155 AVFLASGMSSYITGQTLHVDGGTQAAGGWYHHPQTGAPTLGPG------
TH_3505|M.thermoresistible__bu AVFLASEMSSYITGQTLHVDGGTQAAGGWYHHPRTGAPTLGPGPVR---
MLBr_00862|M.leprae_Br4923 GPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI
..