For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TTHVPVAVIGGGQAGLSVSWYLVRAGIEHIVIESKTPMHAWADTRWDNFTLVTPNWHCRLPGYPYAGPDP DGFMTRDEVVDWLAGWLDTFDPPLRNHTQVTRLQNRAGGGFEVTLRDESGQSTLTCDHAVIATGGYPVPV IPSYAAQLDETILQIHSEQYRNAGTLPDGAVLVVGTGQSGAQIAEDLHLAGRRVHLAVGGAPRVARFYRG RDCMTWLADMGVYDRPAQQYPGGQAAIEKTNHYVTGRDGGRDVDLRQFATEGMRLYGTLADGKDSTLRFE PTLAEALDHADSVYNSICSDIDAHIERNGIDAPPASRYEPVWKPETETTTLDLAAAGITSIVWAIGYRPD YRWIAASAFDGAGRPMQTRGITNVAGLSFVGLPWMHTWGSGRFLGIDRDARHIAATIISSYHESVLRLAM KV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0569 | - | - | 100% (423) | flavoprotein involved in K+ transport |
| M. smegmatis MC2 155 | MSMEG_1682 | - | 8e-75 | 38.82% (407) | flavin-containing monooxygenase FMO |
| M. smegmatis MC2 155 | MSMEG_5022 | - | 5e-09 | 27.81% (187) | flavin-containing monooxygenase FMO |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0916 | - | 4e-09 | 30.69% (189) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_3867 | - | 2e-12 | 29.56% (203) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv0892 | - | 4e-09 | 30.69% (189) | monooxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0958c | - | 1e-08 | 27.94% (204) | putative oxidoreductase |
| M. marinum M | MMAR_2622 | - | 1e-07 | 26.06% (188) | flavin-binding monooxygenase |
| M. avium 104 | MAV_5241 | - | 3e-06 | 27.45% (204) | monooxygenase |
| M. thermoresistible (build 8) | TH_4273 | - | 2e-11 | 31.53% (203) | PUTATIVE FAD dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_0256 | - | 4e-06 | 24.56% (228) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_1222 | - | 0.0 | 77.65% (425) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0916|M.bovis_AF2122/97 --------------------------------------------------
Rv0892|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0256|M.ulcerans_Agy99 --------------------------------------------------
MAV_5241|M.avium_104 --------------------------------------------------
MMAR_2622|M.marinum_M MSMAFSDCGHAPSAVPAGPARLTGMPFHDSDDVIRAALAEASAPALLMSM
Mflv_3867|M.gilvum_PYR-GCK --------------------------------------------------
TH_4273|M.thermoresistible__bu --------------------------------------------------
MSMEG_0569|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1222|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0958c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0916|M.bovis_AF2122/97 --------------------------------------------------
Rv0892|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0256|M.ulcerans_Agy99 --------------------------------------------------
MAV_5241|M.avium_104 --------------------------------------------------
MMAR_2622|M.marinum_M VHMTGNLGLLDELPGPSMLIAMDIQGGMSEEDKQTVRERAFEVVRDYRDR
Mflv_3867|M.gilvum_PYR-GCK --------------------------------------------------
TH_4273|M.thermoresistible__bu --------------------------------------------------
MSMEG_0569|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1222|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0958c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0916|M.bovis_AF2122/97 --------------------------------------------------
Rv0892|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0256|M.ulcerans_Agy99 --------------------------------------------------
MAV_5241|M.avium_104 ------------MTETVGPARAKPVMSRKAKWLYAIGRVRAAT-------
MMAR_2622|M.marinum_M GCPAPFLPNRVQLQTMLDVASAGQVTDEFIDYIAADLRISDADQDGPPLR
Mflv_3867|M.gilvum_PYR-GCK --------------------------------------------------
TH_4273|M.thermoresistible__bu --------------------------------------------------
MSMEG_0569|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1222|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0958c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0916|M.bovis_AF2122/97 ---MTGRCPTVAVVGAGMSGMCVAITLLSAGITD-------------VCI
Rv0892|M.tuberculosis_H37Rv ---MTGRCPTVAVVGAGMSGMCVAITLLSAGITD-------------VCI
MUL_0256|M.ulcerans_Agy99 ---MTRRDPSVAIVGAAMAGICMAITLLNSGITD-------------VTI
MAV_5241|M.avium_104 ---RRRRGPKVAIIGAGFGGLGAAVALRRAGIDD-------------LVI
MMAR_2622|M.marinum_M STPSQRSGFPVLVIGCGEAGLLAGIKLKQAGLP--------------FVI
Mflv_3867|M.gilvum_PYR-GCK ----------MVVLGAGPAGLGIARELKHRHGVD-------------PLI
TH_4273|M.thermoresistible__bu -----MNDHQVAVIGAGPSGVAAAVSLRDR-GIR-------------PLL
MSMEG_0569|M.smegmatis_MC2_155 ----MTTHVPVAVIGGGQAGLSVSWYLVRAGIEH-------------IVI
Mvan_1222|M.vanbaalenii_PYR-1 ----MSTHVPVAVIGGGQAGLSVSWYLSRAGIEH-------------VVL
MAB_0958c|M.abscessus_ATCC_199 -------MTTVAVIGGGQAGIAAGYFLRRRGLEPLSRRQPADAPGHRFVI
: ::* . .*: . * :
Mb0916|M.bovis_AF2122/97 YEKADDVGGTWRDNTYPGLTCDVPSRLYQYS-FAKNPNWTQMFSRGGEIQ
Rv0892|M.tuberculosis_H37Rv YEKADDVGGTWRDNTYPGLTCDVPSRLYQYS-FAKNPNWTQMFSRGGEIQ
MUL_0256|M.ulcerans_Agy99 YEKADEVGGTWRENTYPGLVCDVPSRLYHYS-FAKNPDWSNLFSPGGEIQ
MAV_5241|M.avium_104 IEAADGVGGTWRRNTYPGAACDIQSHLYSFS-FAPNASWSRTYARQPEIL
MMAR_2622|M.marinum_M IEKQAGVGGTWRANRYPGCRVDIANHYYAYS-FEPNDHWSHSYSEQPEIL
Mflv_3867|M.gilvum_PYR-GCK VDRSDAPAASWRAR-YDGFRLNTCGFWSHLP-GQRIPLSFGRWPTRDQMV
TH_4273|M.thermoresistible__bu IDRAEHVGASWRAR-YDRLRLNTGRLTSHLP-NRPYPAGTAVFPTRDQVV
MSMEG_0569|M.smegmatis_MC2_155 ESKT--PMHAWADTRWDNFTLVTPNWHCRLPGYPYAGPDPDGFMTRDEVV
Mvan_1222|M.vanbaalenii_PYR-1 EAAT--PVHAWADSRWDNFTLVTPNWHCRLPGYAYDGPDPDGFMTRDEVV
MAB_0958c|M.abscessus_ATCC_199 LDHSPGPGGAWQFR-WPTLTLDNTNRIYQLPGLPFDEMG--TIRASTAMP
:* : . :
Mb0916|M.bovis_AF2122/97 DYLRGIAERYGLRHRIRFGATVVSARFD--DGRWVLRTDSG----TESTV
Rv0892|M.tuberculosis_H37Rv DYLRGIAERYGLRHRIRFGATVVSARFD--DGRWVLRTDSG----TESTV
MUL_0256|M.ulcerans_Agy99 SYFCGIADRYRLRDRIRFGTEIVSARFE--DDHWSVVTDSG----EETAV
MAV_5241|M.avium_104 AYLESVADAFDLRRHLMLDTTVRSLRWNPHTAAWDCRIDRGG-HPATLSA
MMAR_2622|M.marinum_M NYLNDVAQRYEITPHVRFNTEVVSAAWQDESDSWAVRIRDHDGSAEVLSA
Mflv_3867|M.gilvum_PYR-GCK EYFDDYVRRQGLR--LRLGVRAERIDRD--GAGWSITTDDE-----DVRA
TH_4273|M.thermoresistible__bu AHLDRHAREDGID--LLLGTTVARVDRD--GEGWRLWTSGG-----DVCA
MSMEG_0569|M.smegmatis_MC2_155 DWLAGWLDTFDPP--LRNHTQVTRLQNR-AGGGFEVTLRDES-GQSTLTC
Mvan_1222|M.vanbaalenii_PYR-1 DWLSGWLDTFDAP--VRTHTRVTRLRNG-TDGGFELTLRTDA-GEETLSC
MAB_0958c|M.abscessus_ATCC_199 RYFGEYEDRYALDVRRPVHVRAVRPARR----GFTIDTSVG-----EFPV
: . :
Mb0916|M.bovis_AF2122/97 DFLISATGVLHHPRIPPIAGLDDFRGTVFHSARWDHTVPLLGRRIAVIGT
Rv0892|M.tuberculosis_H37Rv DFLISATGVLHHPRIPPIAGLDDFRGTVFHSARWDHTVPLLGRRIAVIGT
MUL_0256|M.ulcerans_Agy99 DFLIVATGLLHHPRVPAIAGLDDFGGSAFHSARWDQRVAVQGRRVAVIGS
MAV_5241|M.avium_104 DVVVCAVGLFGAAKLPDIDGLAGFAGPVLHTAQWDHDLDLAGRTVAVIGT
MMAR_2622|M.marinum_M RAVICAVGQFSNPVIPDIKGGKDFAGPSFHTADWDERVELAGKRVAVIGA
Mflv_3867|M.gilvum_PYR-GCK SAVVVALGNHNTPGLPPWPGMDGFTGQLLHAADYRSAEPFGGQEVLVVGS
TH_4273|M.thermoresistible__bu RHVVVATGYEHTPNIPDWPGADGFTGRLLHSSAYRNPIPFSGLRVLVVGA
MSMEG_0569|M.smegmatis_MC2_155 DHAVIATGGYPVPVIPSYAAQLDETILQIHSEQYRNAGTLPDGAVLVVGT
Mvan_1222|M.vanbaalenii_PYR-1 AHAVVATGGYPIPVLPSFAGALAPSVTQIHSEQYRNAGQLPDGAVLVVGT
MAB_0958c|M.abscessus_ATCC_199 DGLINATGTWDKPFVPFVPGAGTFRGRQLHTHDYQRPEEFTGQHVLVVGG
: * * . :* . :*: : . . : *:*
Mb0916|M.bovis_AF2122/97 GSTGVQLVCGLAG-VAGKVTMFQRTAQWVLP--WPNPRYSKLARVFHRAF
Rv0892|M.tuberculosis_H37Rv GSTGVQLVCGLAG-VAGKVTMFQRTAQWVLP--WPNPRYSKLARVFHRAF
MUL_0256|M.ulcerans_Agy99 GSTGVQLVSALAG-VAAKVTMFQRTRQWILL--WPNRQYSKVSRACYRGA
MAV_5241|M.avium_104 GASGVQLVPELAG-TAGHVTVFQRTPPWMVP--KDDRPYSATELARFKRN
MMAR_2622|M.marinum_M GASGFQLVPAIAD-MTERVDVYQRTAQWMAPNINYHAAVSDPAKWAVRHL
Mflv_3867|M.gilvum_PYR-GCK GNSAVDIALQLSSAVAAKVWMSVRTPPQLVPRSTAG-LPIDTLGPLLATL
TH_4273|M.thermoresistible__bu GSSAMEIVHDVATGGAAQAWLAVRTPPNIMLRALPGGFPSDYLATPLFDA
MSMEG_0569|M.smegmatis_MC2_155 GQSGAQIAEDLHL-AGRRVHLAVGGAPRVARFYRGRDCMTWLADMGVYDR
Mvan_1222|M.vanbaalenii_PYR-1 GQSGAQIAEDLHL-AGRQVHLAVGNAPRVARFYRGRDCMTWLADMGLYDR
MAB_0958c|M.abscessus_ATCC_199 GISAVQLLMEISG-------IASVTTSWVTR-----------------RE
* :. :: : : :
Mb0916|M.bovis_AF2122/97 P-CLGSLAYKAYS-----------LSFETFAVALSNPGLHRKLVGAVCRA
Rv0892|M.tuberculosis_H37Rv P-CLGSLAYKAYS-----------LSFETFAVALSNPGLHRKLVGAVCRA
MUL_0256|M.ulcerans_Agy99 P-WLESLAYKIWG-----------RAFEQFTAALTRPGWHRRVTGMTCRA
MAV_5241|M.avium_104 PLALRRTRWQIWK-----------FQHDNTATFADDPVVTARSR-IATSF
MMAR_2622|M.marinum_M PYYGRWLRFVTWWPIADGAAHLTVIDPDWENGGLSVSAANHQVRELFIAW
Mflv_3867|M.gilvum_PYR-GCK P------------------------------VWLLDGAAAAMRRVWFGEL
TH_4273|M.thermoresistible__bu P------------------------------VGLVDRMARLAQRATIGDL
MSMEG_0569|M.smegmatis_MC2_155 P-------------------------------AQQYPGGQAAIEKTNHYV
Mvan_1222|M.vanbaalenii_PYR-1 P-------------------------------AAEYPGGKAAIEKTNHYV
MAB_0958c|M.abscessus_ATCC_199 P-------------------------------VFVTDLTVERLRAAVAGV
*
Mb0916|M.bovis_AF2122/97 SLRRVRDPRLRRALTPDYEPMCKRLVMSGG-FYRAIQRDDVELVTAGIDH
Rv0892|M.tuberculosis_H37Rv SLRRVRDPRLRRALTPDYEPMCKRLVMSGG-FYRAIQRDDVELVTAGIDH
MUL_0256|M.ulcerans_Agy99 SLRLVRDPHLRQALTPDYQPMCKRLVMSSG-FYRAIQRDDVELVTTGIDR
MAV_5241|M.avium_104 LDRTVADESLRRALTPDYPFRCKRVLLGDD-YYRALQRDNVELVTDPIAR
MMAR_2622|M.marinum_M MRAFTDDEQLLAKVTPNYPPMGKRTLQDNGTWLKTLQRDDVELIREGVAE
Mflv_3867|M.gilvum_PYR-GCK AGVGLPPP--RQGIYTALRAQAKVPTIAD-ELVPRVKDGRIEIVSA-VES
TH_4273|M.thermoresistible__bu SEYGLPTP--REGVFARGKRLGRAPVIVDREVVDAIRARRFEVVRT-IGR
MSMEG_0569|M.smegmatis_MC2_155 TGRDGGRDVDLRQFATEGMRLYGTLADGKD--------STLRFEPTLAEA
Mvan_1222|M.vanbaalenii_PYR-1 TGRDGGRDIDLRRFAAEGMRLYGTLVGGHD--------TAVQFAPTLRRA
MAB_0958c|M.abscessus_ATCC_199 DERSRRGEPQRSVVSATGLPWTAETAEASR--------RGVLTRRPMFSR
. . .
Mb0916|M.bovis_AF2122/97 VEHRGIVTDDGVLHEVDVIVLATGFDSHA-FFRPMQLTGRDGIRIDDVWQ
Rv0892|M.tuberculosis_H37Rv VEHRGIVTDDGVLHEVDVIVLATGFDSHA-FFRPMQLTGRDGIRIDDVWQ
MUL_0256|M.ulcerans_Agy99 IENAGIVTDDGVLREVDVIVLATGFDSHA-FFRPMKLIGRDGVEIDELWR
MAV_5241|M.avium_104 IGRMSVITASGAEIEADVIVLATGFETSR-YLSGIEVVGAGGRRLHEHWG
MMAR_2622|M.marinum_M ITAHGVITRDGVYRPADVLIWATGFDVNH-QLGPIRVRGLDGVELNDLWG
Mflv_3867|M.gilvum_PYR-GCK FETNRVVLADGTALAPQVVIGATGYRR-----GLDALVGHLG-----VLT
TH_4273|M.thermoresistible__bu FDGGTVVLTDGRRLQPDAVICATGYSR-----GLEPLVGHLG-----VLD
MSMEG_0569|M.smegmatis_MC2_155 LDHADSVYN-SICSDIDAHIERNGIDAPP-ASRYEPVWKPETETTTLDLA
Mvan_1222|M.vanbaalenii_PYR-1 LDHADVVYN-SICADIDAYIERTGAAAGP-PGRYTPVWEPETEPTALDLA
MAB_0958c|M.abscessus_ATCC_199 ITPTGVTWPDGSSLEVDVILWCTGFRHALDHLAPLHLRNGRG-------G
. . :. : .* :
Mb0916|M.bovis_AF2122/97 DGPHAHQTVAIPGFPNFFMMLGPHS-PVGNFPLTAVAESQAEHIVQWIKR
Rv0892|M.tuberculosis_H37Rv DGPHAHQTVAIPGFPNFFMMLGPHS-PVGNFPLTAVAESQAEHIVQWIKR
MUL_0256|M.ulcerans_Agy99 GGPYAYQTVAMPGFPNFFMMLDPHS-PVGNYPLTGIAESQADHILRWIQR
MAV_5241|M.avium_104 EEPSAYLGVAVSGFPNFFMLYGPNT-NQGGNSIVYILEAGARLVASAVSR
MMAR_2622|M.marinum_M DAAYAYLGISVPGFPNFYCMYGPGTNAVNGASIIYNSECQMRYILGCIDM
Mflv_3867|M.gilvum_PYR-GCK DDGHPVVNGPPAAAPGLWFAG---------------YEEPLIGPLRAFRR
TH_4273|M.thermoresistible__bu DRGLPRSAGEVAAALGLWFIG---------------FQS-RPGLISFAAK
MSMEG_0569|M.smegmatis_MC2_155 AAGITSIVWAIGYRPDYRWIAASAFDGAGRPMQTRGITNVAGLSFVGLPW
Mvan_1222|M.vanbaalenii_PYR-1 AEGVTAIVWAIGYRPDYRWIEASAFDGGGRPMQNRGVTTVPGLSFIGLPW
MAB_0958c|M.abscessus_ATCC_199 ITMTGRLLTQVAGQPAIHLLG-------------------YGSSASTIGA
Mb0916|M.bovis_AF2122/97 WRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTG--CDSWYLNKDG-IP
Rv0892|M.tuberculosis_H37Rv WRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTG--CDSWYLNKDG-IP
MUL_0256|M.ulcerans_Agy99 WRSSEFDTVEPTSWATDEFNAKLRAAMPKTVWTTG--CSSWYLNDDW-VP
MAV_5241|M.avium_104 LAR-RGGFLEVRPEAEKRFNDRLSADLERTIWTR---CDSYFRSPTGRIV
MMAR_2622|M.marinum_M VLSEGARYAVLRDGVCSDYNQRSQRQLETMVYTHPAVCSSYYKNAAGDVP
Mflv_3867|M.gilvum_PYR-GCK HAPDVAE-VVSHLAASSAASQTLSR-------------------------
TH_4273|M.thermoresistible__bu QSQRIAKRIAAELVAAPAITPVADGG------------------------
MSMEG_0569|M.smegmatis_MC2_155 MHTWGSGRFLGIDRDARHIAATIISSYHESV----LRLAMKV--------
Mvan_1222|M.vanbaalenii_PYR-1 MHTWGSGRFLGVDSDARHIAETIIGAHRDSAPASPLRLAVGG--------
MAB_0958c|M.abscessus_ATCC_199 NRASRAAVVELMNYLEGRTA------------------------------
Mb0916|M.bovis_AF2122/97 EVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATSRPQSA-
Rv0892|M.tuberculosis_H37Rv EVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATSRPQSA-
MUL_0256|M.ulcerans_Agy99 EVWPFAPAEHRAMLANPDLDQYHLRRRPEVLAW-------
MAV_5241|M.avium_104 TQWPYTELDYARWTWRLRRRDWIHHRCAPGAATVGAAQEF
MMAR_2622|M.marinum_M TLFAWRILDYWNWTNRPDRNHYEFRR--------------
Mflv_3867|M.gilvum_PYR-GCK ----------------------------------------
TH_4273|M.thermoresistible__bu ----------------------------------------
MSMEG_0569|M.smegmatis_MC2_155 ----------------------------------------
Mvan_1222|M.vanbaalenii_PYR-1 ----------------------------------------
MAB_0958c|M.abscessus_ATCC_199 ----------------------------------------