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STHVPVAVIGGGQAGLSVSWYLSRAGIEHVVLEAATPVHAWADSRWDNFTLVTPNWHCRLPGYAYDGPDP DGFMTRDEVVDWLSGWLDTFDAPVRTHTRVTRLRNGTDGGFELTLRTDAGEETLSCAHAVVATGGYPIPV LPSFAGALAPSVTQIHSEQYRNAGQLPDGAVLVVGTGQSGAQIAEDLHLAGRQVHLAVGNAPRVARFYRG RDCMTWLADMGLYDRPAAEYPGGKAAIEKTNHYVTGRDGGRDIDLRRFAAEGMRLYGTLVGGHDTAVQFA PTLRRALDHADVVYNSICADIDAYIERTGAAAGPPGRYTPVWEPETEPTALDLAAEGVTAIVWAIGYRPD YRWIEASAFDGGGRPMQNRGVTTVPGLSFIGLPWMHTWGSGRFLGVDSDARHIAETIIGAHRDSAPASPL RLAVGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1222 | - | - | 100% (427) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0787 | - | 1e-08 | 25.79% (221) | hypothetical protein Mvan_0787 |
| M. vanbaalenii PYR-1 | Mvan_2059 | - | 8e-08 | 26.56% (192) | putative monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0916 | - | 4e-09 | 30.05% (183) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_3867 | - | 5e-12 | 30.39% (204) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv0892 | - | 4e-09 | 30.05% (183) | monooxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0958c | - | 8e-11 | 28.43% (197) | putative oxidoreductase |
| M. marinum M | MMAR_2789 | - | 2e-09 | 29.06% (203) | monooxygenase |
| M. avium 104 | MAV_5241 | - | 6e-09 | 29.76% (205) | monooxygenase |
| M. smegmatis MC2 155 | MSMEG_0569 | - | 0.0 | 77.65% (425) | flavoprotein involved in K+ transport |
| M. thermoresistible (build 8) | TH_4273 | - | 2e-13 | 32.51% (203) | PUTATIVE FAD dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_0256 | - | 1e-06 | 26.29% (213) | monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0916|M.bovis_AF2122/97 --------------------------------------------------
Rv0892|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0256|M.ulcerans_Agy99 --------------------------------------------------
MAV_5241|M.avium_104 --------------------------------------------------
MMAR_2789|M.marinum_M MRSRYAGLPFATTTAEIAAALEDVSIPTLLLSLVHITGDARFIRDFEPIG
Mflv_3867|M.gilvum_PYR-GCK --------------------------------------------------
TH_4273|M.thermoresistible__bu --------------------------------------------------
Mvan_1222|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0569|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0958c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0916|M.bovis_AF2122/97 --------------------------------------------------
Rv0892|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0256|M.ulcerans_Agy99 --------------------------------------------------
MAV_5241|M.avium_104 --------------------------------------------------
MMAR_2789|M.marinum_M LFLNEVQGFMSEDDKARARTEALAVISEYRDQGCPEPKPLSGELIREMLD
Mflv_3867|M.gilvum_PYR-GCK --------------------------------------------------
TH_4273|M.thermoresistible__bu --------------------------------------------------
Mvan_1222|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0569|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0958c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0916|M.bovis_AF2122/97 ----------------------------------MTGRCPTVAVVGAGMS
Rv0892|M.tuberculosis_H37Rv ----------------------------------MTGRCPTVAVVGAGMS
MUL_0256|M.ulcerans_Agy99 ----------------------------------MTRRDPSVAIVGAAMA
MAV_5241|M.avium_104 ---MTETVGPARAKPVMSRKAKWLYAIGRVRAATRRRRGPKVAIIGAGFG
MMAR_2789|M.marinum_M WAACEHVPDDYLPLLAEEMDLEGLDPRQPVALPSESAAEFPVIVIGCGES
Mflv_3867|M.gilvum_PYR-GCK -----------------------------------------MVVLGAGPA
TH_4273|M.thermoresistible__bu ------------------------------------MNDHQVAVIGAGPS
Mvan_1222|M.vanbaalenii_PYR-1 -----------------------------------MSTHVPVAVIGGGQA
MSMEG_0569|M.smegmatis_MC2_155 -----------------------------------MTTHVPVAVIGGGQA
MAB_0958c|M.abscessus_ATCC_199 --------------------------------------MTTVAVIGGGQA
: ::* . .
Mb0916|M.bovis_AF2122/97 GMCVAITLLSAGITD-------------VCIYEKADDVGGTWRDNTYPGL
Rv0892|M.tuberculosis_H37Rv GMCVAITLLSAGITD-------------VCIYEKADDVGGTWRDNTYPGL
MUL_0256|M.ulcerans_Agy99 GICMAITLLNSGITD-------------VTIYEKADEVGGTWRENTYPGL
MAV_5241|M.avium_104 GLGAAVALRRAGIDD-------------LVIIEAADGVGGTWRRNTYPGA
MMAR_2789|M.marinum_M GILAGIRLKQANIA--------------FTIVEKNAGPGGTWWENRYPGA
Mflv_3867|M.gilvum_PYR-GCK GLGIARELKHRHGVD-------------PLIVDRSDAPAASWRAR-YDGF
TH_4273|M.thermoresistible__bu GVAAAVSLRDR-GIR-------------PLLIDRAEHVGASWRAR-YDRL
Mvan_1222|M.vanbaalenii_PYR-1 GLSVSWYLSRAGIEH-------------VVLEAAT--PVHAWADSRWDNF
MSMEG_0569|M.smegmatis_MC2_155 GLSVSWYLVRAGIEH-------------IVIESKT--PMHAWADTRWDNF
MAB_0958c|M.abscessus_ATCC_199 GIAAGYFLRRRGLEPLSRRQPADAPGHRFVILDHSPGPGGAWQFR-WPTL
*: . * : :* :
Mb0916|M.bovis_AF2122/97 TCDVPSRLYQYS-FAKNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFG
Rv0892|M.tuberculosis_H37Rv TCDVPSRLYQYS-FAKNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFG
MUL_0256|M.ulcerans_Agy99 VCDVPSRLYHYS-FAKNPDWSNLFSPGGEIQSYFCGIADRYRLRDRIRFG
MAV_5241|M.avium_104 ACDIQSHLYSFS-FAPNASWSRTYARQPEILAYLESVADAFDLRRHLMLD
MMAR_2789|M.marinum_M RVDVANHFYCYS-FEPNNDWTHFFAEQWELQDYFAKAIDTHDLGGHIQWN
Mflv_3867|M.gilvum_PYR-GCK RLNTCGFWSHLP-GQRIPLSFGRWPTRDQMVEYFDDYVRRQGLRLRLGVR
TH_4273|M.thermoresistible__bu RLNTGRLTSHLP-NRPYPAGTAVFPTRDQVVAHLDRHAREDGIDLLLGTT
Mvan_1222|M.vanbaalenii_PYR-1 TLVTPNWHCRLPGYAYDGPDPDGFMTRDEVVDWLSGWLDTFDAPVRTHTR
MSMEG_0569|M.smegmatis_MC2_155 TLVTPNWHCRLPGYPYAGPDPDGFMTRDEVVDWLAGWLDTFDPPLRNHTQ
MAB_0958c|M.abscessus_ATCC_199 TLDNTNRIYQLP--GLPFDEMGTIRASTAMPRYFGEYEDRYALDVRRPVH
. : :
Mb0916|M.bovis_AF2122/97 ATVVSARFD--DGRWVLRTDSG----TESTVDFLISATGVLHHPRIPPIA
Rv0892|M.tuberculosis_H37Rv ATVVSARFD--DGRWVLRTDSG----TESTVDFLISATGVLHHPRIPPIA
MUL_0256|M.ulcerans_Agy99 TEIVSARFE--DDHWSVVTDSG----EETAVDFLIVATGLLHHPRVPAIA
MAV_5241|M.avium_104 TTVRSLRWNPHTAAWDCRIDRGG-HPATLSADVVVCAVGLFGAAKLPDID
MMAR_2789|M.marinum_M TEALGAEWNDDDGVWTVRLRSADGTTRTLSARALITAVGQLNRPYVPEFD
Mflv_3867|M.gilvum_PYR-GCK AERIDRD----GAGWSITTDDE-----DVRASAVVVALGNHNTPGLPPWP
TH_4273|M.thermoresistible__bu VARVDRD----GEGWRLWTSGG-----DVCARHVVVATGYEHTPNIPDWP
Mvan_1222|M.vanbaalenii_PYR-1 VTRLRNGTDG-GFELTLRTDAGE---ETLSCAHAVVATGGYPIPVLPSFA
MSMEG_0569|M.smegmatis_MC2_155 VTRLQNRAGG-GFEVTLRDESGQ---STLTCDHAVIATGGYPVPVIPSYA
MAB_0958c|M.abscessus_ATCC_199 VRAVRPARR----GFTIDTSVG-----EFPVDGLINATGTWDKPFVPFVP
. : * * . :*
Mb0916|M.bovis_AF2122/97 GLDDFRGTVFHSARWDHTVPLLGRRIAVIGTGSTGVQLVCGLAG-VAGKV
Rv0892|M.tuberculosis_H37Rv GLDDFRGTVFHSARWDHTVPLLGRRIAVIGTGSTGVQLVCGLAG-VAGKV
MUL_0256|M.ulcerans_Agy99 GLDDFGGSAFHSARWDQRVAVQGRRVAVIGSGSTGVQLVSALAG-VAAKV
MAV_5241|M.avium_104 GLAGFAGPVLHTAQWDHDLDLAGRTVAVIGTGASGVQLVPELAG-TAGHV
MMAR_2789|M.marinum_M GADTFAGPSFHSAAWDRSVDLTGKRVALVGAGASGFQIAPAIAG-DVAQL
Mflv_3867|M.gilvum_PYR-GCK GMDGFTGQLLHAADYRSAEPFGGQEVLVVGSGNSAVDIALQLSSAVAAKV
TH_4273|M.thermoresistible__bu GADGFTGRLLHSSAYRNPIPFSGLRVLVVGAGSSAMEIVHDVATGGAAQA
Mvan_1222|M.vanbaalenii_PYR-1 GALAPSVTQIHSEQYRNAGQLPDGAVLVVGTGQSGAQIAEDLHL-AGRQV
MSMEG_0569|M.smegmatis_MC2_155 AQLDETILQIHSEQYRNAGTLPDGAVLVVGTGQSGAQIAEDLHL-AGRRV
MAB_0958c|M.abscessus_ATCC_199 GAGTFRGRQLHTHDYQRPEEFTGQHVLVVGGGISAVQLLMEISGIASVTT
. :*: : . . : ::* * :. :: :
Mb0916|M.bovis_AF2122/97 TMFQRTAQWVLP---WPNPRYSKLARVFHRAFP-CLGSLAYKAYSLSFET
Rv0892|M.tuberculosis_H37Rv TMFQRTAQWVLP---WPNPRYSKLARVFHRAFP-CLGSLAYKAYSLSFET
MUL_0256|M.ulcerans_Agy99 TMFQRTRQWILL---WPNRQYSKVSRACYRGAP-WLESLAYKIWGRAFEQ
MAV_5241|M.avium_104 TVFQRTPPWMVP---KDDRPYSATELARFKRNPLALRRTRWQIWKFQHDN
MMAR_2789|M.marinum_M SVFQRTAQWMFPNTMYHDEVGDGVRWAMRHLPFYGRWYRFLLLWPGADKG
Mflv_3867|M.gilvum_PYR-GCK WMSVRTPPQLVPRSTAG-LPIDTLGPLLATLPVWLLDGAAAAMRRVWFGE
TH_4273|M.thermoresistible__bu WLAVRTPPNIMLRALPGGFPSDYLATPLFDAPVGLVDRMARLAQRATIGD
Mvan_1222|M.vanbaalenii_PYR-1 HLAVGNAPRVAR-----FYRGRDCMTWLADMGLYDRPAAEYPGGKAAIEK
MSMEG_0569|M.smegmatis_MC2_155 HLAVGGAPRVAR-----FYRGRDCMTWLADMGVYDRPAQQYPGGQAAIEK
MAB_0958c|M.abscessus_ATCC_199 SWVTRREPVFVT----------------------DLTVERLRAAVAGVDE
.
Mb0916|M.bovis_AF2122/97 FAVALSNP----------GLHRKLVGAVCRASLRRVRD-PRLRRALTPDY
Rv0892|M.tuberculosis_H37Rv FAVALSNP----------GLHRKLVGAVCRASLRRVRD-PRLRRALTPDY
MUL_0256|M.ulcerans_Agy99 FTAALTRP----------GWHRRVTGMTCRASLRLVRD-PHLRQALTPDY
MAV_5241|M.avium_104 TATFADDP----------VVTARSR-IATSFLDRTVAD-ESLRRALTPDY
MMAR_2789|M.marinum_M LDAARTDPNYADQDYAVSDINAAARMMFSQWISSQVADGDALLSKVLPDY
Mflv_3867|M.gilvum_PYR-GCK LAGVGLPP---------------------------------PRQGIYTAL
TH_4273|M.thermoresistible__bu LSEYGLPT---------------------------------PREGVFARG
Mvan_1222|M.vanbaalenii_PYR-1 TNHYVTGR----------------------------------DGGRDIDL
MSMEG_0569|M.smegmatis_MC2_155 TNHYVTGR----------------------------------DGGRDVDL
MAB_0958c|M.abscessus_ATCC_199 RSRRGEPQ------------------------------------------
Mb0916|M.bovis_AF2122/97 EPMCKRLVMSGG-FYRAIQRDDVELVTAGIDHVEHRGIVTDDGVLHEVDV
Rv0892|M.tuberculosis_H37Rv EPMCKRLVMSGG-FYRAIQRDDVELVTAGIDHVEHRGIVTDDGVLHEVDV
MUL_0256|M.ulcerans_Agy99 QPMCKRLVMSSG-FYRAIQRDDVELVTTGIDRIENAGIVTDDGVLREVDV
MAV_5241|M.avium_104 PFRCKRVLLGDD-YYRALQRDNVELVTDPIARIGRMSVITASGAEIEADV
MMAR_2789|M.marinum_M PATGKRTLQDNGSWLATLQRDNVDLVRTPIQRITPTGIVTEDGVTHSVDV
Mflv_3867|M.gilvum_PYR-GCK RAQAKVPTIAD-ELVPRVKDGRIEIVSA-VESFETNRVVLADGTALAPQV
TH_4273|M.thermoresistible__bu KRLGRAPVIVDREVVDAIRARRFEVVRT-IGRFDGGTVVLTDGRRLQPDA
Mvan_1222|M.vanbaalenii_PYR-1 RRFAAEGMRLYG-TLVGGHDTAVQFAPTLRRALDHADVVYN-SICADIDA
MSMEG_0569|M.smegmatis_MC2_155 RQFATEGMRLYG-TLADGKDSTLRFEPTLAEALDHADSVYN-SICSDIDA
MAB_0958c|M.abscessus_ATCC_199 RSVVSATGLPWTAETAEASRRGVLTRRPMFSRITPTGVTWPDGSSLEVDV
. . . :.
Mb0916|M.bovis_AF2122/97 IVLATGFDSHAFFRPMQLTGRDGIRIDDVWQDGPHAHQTVAIPGFPNFFM
Rv0892|M.tuberculosis_H37Rv IVLATGFDSHAFFRPMQLTGRDGIRIDDVWQDGPHAHQTVAIPGFPNFFM
MUL_0256|M.ulcerans_Agy99 IVLATGFDSHAFFRPMKLIGRDGVEIDELWRGGPYAYQTVAMPGFPNFFM
MAV_5241|M.avium_104 IVLATGFETSRYLSGIEVVGAGGRRLHEHWGEEPSAYLGVAVSGFPNFFM
MMAR_2789|M.marinum_M IVYATGFRHTDVLWPLQVIGRNGIDLHRVWGRRPYAYLGITVPGFPNLFL
Mflv_3867|M.gilvum_PYR-GCK VIGATGYR----------------------------------RGLDALVG
TH_4273|M.thermoresistible__bu VICATGYS----------------------------------RGLEPLVG
Mvan_1222|M.vanbaalenii_PYR-1 YIERTGAAAG---------------------------------PPGRYTP
MSMEG_0569|M.smegmatis_MC2_155 HIERNGIDAP---------------------------------PASRYEP
MAB_0958c|M.abscessus_ATCC_199 ILWCTGFR--------------------------------------HALD
: .*
Mb0916|M.bovis_AF2122/97 MLGPHSPVGNF-PLTAVAESQAEHIVQWIKRWRHGEFDTMEPKSAATEAY
Rv0892|M.tuberculosis_H37Rv MLGPHSPVGNF-PLTAVAESQAEHIVQWIKRWRHGEFDTMEPKSAATEAY
MUL_0256|M.ulcerans_Agy99 MLDPHSPVGNY-PLTGIAESQADHILRWIQRWRSSEFDTVEPTSWATDEF
MAV_5241|M.avium_104 LYGPNTNQGGN-SIVYILEAGARLVASAVSRLAR-RGGFLEVRPEAEKRF
MMAR_2789|M.marinum_M IYGPGTHLAHGGSLIFQSELQMRYINLCLERLVADGIGSLEPTDEAAAGW
Mflv_3867|M.gilvum_PYR-GCK HLGVLTDDGHP----VVNGPPAAAPGLWFAGYEEPLIGPLRAFRRHAPDV
TH_4273|M.thermoresistible__bu HLGVLDDRGLP----RSAGEVAAALGLWFIGFQS-RPGLISFAAKQSQRI
Mvan_1222|M.vanbaalenii_PYR-1 VWEPETEPTAL----DLAAEGVTAIVWAIGYRPDYRWIEASAFDGGGRPM
MSMEG_0569|M.smegmatis_MC2_155 VWKPETETTTL----DLAAAGITSIVWAIGYRPDYRWIAASAFDGAGRPM
MAB_0958c|M.abscessus_ATCC_199 HLAPLHLRNGR--------GGITMTGRLLTQVAGQPAIHLLGYGSSASTI
.
Mb0916|M.bovis_AF2122/97 NTVLRAAMPNTVWTTG--CDSWYLNKDG-IPEVWPFAPAKHRAMLANLHP
Rv0892|M.tuberculosis_H37Rv NTVLRAAMPNTVWTTG--CDSWYLNKDG-IPEVWPFAPAKHRAMLANLHP
MUL_0256|M.ulcerans_Agy99 NAKLRAAMPKTVWTTG--CSSWYLNDDW-VPEVWPFAPAEHRAMLANPDL
MAV_5241|M.avium_104 NDRLSADLERTIWTR---CDSYFRSPTGRIVTQWPYTELDYARWTWRLRR
MMAR_2789|M.marinum_M HERTQAEIKKMVWSHPAVKHSYFKNADGEIHTVSPWRLNEYWAAVRQPDW
Mflv_3867|M.gilvum_PYR-GCK AE-VVSHLAASSAASQTLSR------------------------------
TH_4273|M.thermoresistible__bu AKRIAAELVAAPAITPVADGG-----------------------------
Mvan_1222|M.vanbaalenii_PYR-1 QNRGVTTVPGLSFIGLPWMHTWGSGRFLGVDSDARHIAETIIGAHRDSAP
MSMEG_0569|M.smegmatis_MC2_155 QTRGITNVAGLSFVGLPWMHTWGSGRFLGIDRDARHIAATIISSYHESV-
MAB_0958c|M.abscessus_ATCC_199 GANRASRAAVVELMNYLEGRTA----------------------------
:
Mb0916|M.bovis_AF2122/97 EEYDLRRYAAVRATSRPQSA-
Rv0892|M.tuberculosis_H37Rv EEYDLRRYAAVRATSRPQSA-
MUL_0256|M.ulcerans_Agy99 DQYHLRRRPEVLAW-------
MAV_5241|M.avium_104 RDWIHHRCAPGAATVGAAQEF
MMAR_2789|M.marinum_M SQFVLRQRK------------
Mflv_3867|M.gilvum_PYR-GCK ---------------------
TH_4273|M.thermoresistible__bu ---------------------
Mvan_1222|M.vanbaalenii_PYR-1 ASPLRLAVGG-----------
MSMEG_0569|M.smegmatis_MC2_155 ---LRLAMKV-----------
MAB_0958c|M.abscessus_ATCC_199 ---------------------