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M. smegmatis MC2 155 MSMEG_1628 (-)

annotation: oxidoreductase, short chain dehydrogenase/reductase family protein
coordinates: 1718346 - 1719197
length: 283

MSYPTTRPATWFVTGTSKGLGLELVRQLLARGDNVAATTRSTERLHAGLEGVDTGSLLPIEVDLADPSAV
HKAVTATVERFGHLDVVVNNAGYGFLASVEDTTDADIRQMLDVQVIGTWNVLRAAIPHLRAARSGHIVNV
SSILGLTAMPGWGLYCAGKFALNGMSEALAGEMAEFGVNVSIVEPGYFRTSFLTTDSLALPEATSDAYPG
IHEMTQNHLALQGSQLGDPVKGAEAIIDIAVAGQGPLHQLLGSDSYEYAQAKVAALSGDIEAGRELAFTT
DHR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_1628--100% (283)oxidoreductase, short chain dehydrogenase/reductase family protein
M. smegmatis MC2 155MSMEG_0524-5e-5440.88% (274) short chain dehydrogenase
M. smegmatis MC2 155MSMEG_2808-2e-4638.32% (274) short-chain dehydrogenase/reductase SDR

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1385fabG2e-2335.14% (185) 3-ketoacyl-(acyl-carrier-protein) reductase
M. gilvum PYR-GCKMflv_0930-8e-4235.51% (276) short-chain dehydrogenase/reductase SDR
M. tuberculosis H37RvRv1350fabG2e-2335.14% (185) 3-ketoacyl-(acyl-carrier-protein) reductase
M. leprae Br4923MLBr_01094-7e-2234.78% (184) short chain alcohol dehydrogenase
M. abscessus ATCC 19977MAB_3405-8e-2736.90% (187) short chain dehydrogenase
M. marinum MMMAR_1614-3e-4438.87% (247) short chain dehydrogenase
M. avium 104MAV_4982-8e-4738.41% (276) short-chain dehydrogenase/reductase SDR
M. thermoresistible (build 8)TH_3670-4e-3937.60% (242) PUTATIVE short-chain dehydrogenase/reductase SDR
M. ulcerans Agy99MUL_3423-4e-4438.46% (247) short chain dehydrogenase
M. vanbaalenii PYR-1Mvan_5466-1e-12475.97% (283) short-chain dehydrogenase/reductase SDR

CLUSTAL 2.0.9 multiple sequence alignment


Mb1385|M.bovis_AF2122/97            -MASLLNARTAVITGGAQG-LGLAIGQRFVAEGARVVLGDVNLEATEVAA
Rv1350|M.tuberculosis_H37Rv         -MASLLNARTAVITGGAQG-LGLAIGQRFVAEGARVVLGDVNLEATEVAA
MSMEG_1628|M.smegmatis_MC2_155      MSYPTTRPATWFVTGTSKG-LGLELVRQLLARGDNVAATTRSTERLHAGL
Mvan_5466|M.vanbaalenii_PYR-1       MPYPTDNPATWFVTGASRG-LGAELVRQLLRRGDNVAATTRSAERLSAAL
MAV_4982|M.avium_104                ------MPKTWFITGSSRG-LGRALTTAVLDHGDHVVATARRPAQLDELV
TH_3670|M.thermoresistible__bu      MGSNVWGSKVWFITGASRG-FGREWAIAALDRGDRVAATARDVSTLDDLR
MMAR_1614|M.marinum_M               -------MSTWLITGCSTG-LGRALAEAVIDAGHHTVATARSVGGVADLV
MUL_3423|M.ulcerans_Agy99           -------MSTWLITGCSTG-LGRALAEAVIDAGHHTVATARSVGGVADLA
Mflv_0930|M.gilvum_PYR-GCK          ------MSKRWFVTGGTPGGFGVAFAEAALEAGDRVVITSRRPHELAAWA
MAB_3405|M.abscessus_ATCC_1997      --MDKITGKNIAITGAARG-IGYATATALLRRGARVVIGDRDVEALGSAV
MLBr_01094|M.leprae_Br4923          --MEGFAGKVAVVTGAGSG-IGQALAIELARSGAKLAISDVDGEGLAQTE
                                                :**   * :*          * . .             

Mb1385|M.bovis_AF2122/97            KRLGGD-DVALAVRCDVTQADDVDILIRTAVERFGGLDVMVNNAGITRDA
Rv1350|M.tuberculosis_H37Rv         KRLGGD-DVALAVRCDVTQADDVDILIRTAVERFGGLDVMVNNAGITRDA
MSMEG_1628|M.smegmatis_MC2_155      EGVDTG--SLLPIEVDLADPSAVHKAVTATVERFGHLDVVVNNAGYGFLA
Mvan_5466|M.vanbaalenii_PYR-1       AGVDTG--RLLPLVVDLTDAAAVDGAVAAALDRFGRLDVVVNNAGYGFLG
MAV_4982|M.avium_104                DRYGP---RIRACELDVTDRAAARRAIAAAVTAFGRIDVVVNNAGYANSA
TH_3670|M.thermoresistible__bu      DRFGD---AVLAMTLDVTDRAADFAAVQRAHDHFGRLDIVVNNAGYGHFG
MMAR_1614|M.marinum_M               QRSPE---RVLPLALDITEPDQITAAVQAAQQRFGGIDVLVNNAGYGYRA
MUL_3423|M.ulcerans_Agy99           QRSPE---RVLPLALDITEPDQITAAMQAAQQRFGGIDVLVNNAGYGYRA
Mflv_0930|M.gilvum_PYR-GCK          DGYDD---RVLVVPLELTDAAQVQRVVQAAEEHFGGIDVLVNNAGRGWYG
MAB_3405|M.abscessus_ATCC_1997      EGLKEE-GNVDAHPLDVTDPASFKRFLEAASAG-GPIDVLVNNAGVMPIG
MLBr_01094|M.leprae_Br4923          GQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAGIAFTG
                                                   ::::          .    * :: : ****    .

Mb1385|M.bovis_AF2122/97            TMRTMTEEQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMSSVSG-K
Rv1350|M.tuberculosis_H37Rv         TMRTMTEEQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMSSVSG-K
MSMEG_1628|M.smegmatis_MC2_155      SVEDTTDADIRQMLDVQVIGTWNVLRAAIPHLRAARSGHIVNVSSILG-L
Mvan_5466|M.vanbaalenii_PYR-1       AVEETTDAEIRQMLDVQVSGVWNVLRSAVPHLRAARSGHIINVSSILG-L
MAV_4982|M.avium_104                PVEEVSDDDFRAQVETNFFGVVNVTKAALPVLHRQRAGHIVQISSVGGRV
TH_3670|M.thermoresistible__bu      FVEELTETEVRDQMETNFFGALWVTQAALPYLRRQRSGHIIQVSSIGG-V
MMAR_1614|M.marinum_M               AVEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISSIAVAL
MUL_3423|M.ulcerans_Agy99           AVEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISSIAVAL
Mflv_0930|M.gilvum_PYR-GCK          SIEGMDESSLRAMFELNFFAVLSVTRAVLPGMRARGSGWIVNVSSVAG-L
MAB_3405|M.abscessus_ATCC_1997      PFLSTSDRAIRSMLEVNLYGVINGCQLALPEMVARRRGQVVNIASVAG-L
MLBr_01094|M.leprae_Br4923          DVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVFG-L
                                     .       .   .  .  ..    :   . :     * :::::*:    

Mb1385|M.bovis_AF2122/97            VGMVGQTNYSAAKAGIVGMTKAAAKELAHLG--IRVNAIAPGLIRS----
Rv1350|M.tuberculosis_H37Rv         VGMVGQTNYSAAKAGIVGMTKAAAKELAHLG--IRVNAIAPGLIRS----
MSMEG_1628|M.smegmatis_MC2_155      TAMPGWGLYCAGKFALNGMSEALAGEMAEFG--VNVSIVEPGYFRT-SFL
Mvan_5466|M.vanbaalenii_PYR-1       TAVPGWGLYCAGKFALNGMSEALAAELAGFG--IRVTIVEPGYFRT-DFL
MAV_4982|M.avium_104                GGSPGIAAYQASKFAVAGFSEALAAEVAPLG--IKVTIAEPGALRT-EWA
TH_3670|M.thermoresistible__bu      SAFADLGAYHASKWALEGLSQSLSLEVAPFG--IHVTLIEPGGYAT-DWG
MMAR_1614|M.marinum_M               TPVG-SGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFRT-DFA
MUL_3423|M.ulcerans_Agy99           TPVG-SGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFRT-DFA
Mflv_0930|M.gilvum_PYR-GCK          VAAPGFGYYSATKFAIEAVTDALRDEVSTHG--ISVLAVEPGAFRTNAYA
MAB_3405|M.abscessus_ATCC_1997      MAVPGMAVYNASKFGVVGLSRALSDEFAPQG--VQVSAVLPTFTNTELIA
MLBr_01094|M.leprae_Br4923          FSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIKT----
                                            * : * .: ..: :   *.:  *  : *    *    :    

Mb1385|M.bovis_AF2122/97            ----------AMTEAMPQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDL
Rv1350|M.tuberculosis_H37Rv         ----------AMTEAMPQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDL
MSMEG_1628|M.smegmatis_MC2_155      TTDSLALPEATSDAYPGIHEMTQNHLALQGSQLGDPVKGAEAIIDIAVAG
Mvan_5466|M.vanbaalenii_PYR-1       TTESLALPTAAGDAYPAIREMTEQHLQLQGSQLGDPVKGAAAVIHVAVTG
MAV_4982|M.avium_104                GSSMAVATVSP-DYESTVGAMNRRRAGFNRNAPGDPARAAHAIIEVVIAD
TH_3670|M.thermoresistible__bu      GSSARRSATMP-EYAESRAEADRVRS-QRVARPGDPKASAAALLKVVDAE
MMAR_1614|M.marinum_M               GRSLVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAAIITAVESP
MUL_3423|M.ulcerans_Agy99           GRSLVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAAIITAVESP
Mflv_0930|M.gilvum_PYR-GCK          GFANKPVAETIPSYHDMLEEVRAAFVEMDGVQPGDPRRGARAVIAAMAQD
MAB_3405|M.abscessus_ATCC_1997      GTDSTGAQKPVEPEDIAAAVVRIIEKPRVQVTVPKPLGAVTTIVNSLPTG
MLBr_01094|M.leprae_Br4923          ------AIARNATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVR--
                                                                      .*   .   :      

Mb1385|M.bovis_AF2122/97            SS---YMTG----------------------TVLDVTGGRFI--------
Rv1350|M.tuberculosis_H37Rv         SS---YMTG----------------------TVLDVTGGRFI--------
MSMEG_1628|M.smegmatis_MC2_155      QGPLHQLLG---------SDSYEYAQAKVAALSGDIEAGRELAFTTDHR-
Mvan_5466|M.vanbaalenii_PYR-1       GGPLHQLLG---------SDAVSYAEAKIDALVADVKAGRDLALTTDHR-
MAV_4982|M.avium_104                DPPLRLLLGSDALSAALAKSHQQIAEANRWAELSKSIDYPPVATPHRAAR
TH_3670|M.thermoresistible__bu      KPPLRVFFG---------ELPLQIVNADYQSRLQTWEEWQPIAVLAQG--
MMAR_1614|M.marinum_M               APPAFLLLG------PDALMAYRHIAQRRDVEITDWEQLTAGTNLTP---
MUL_3423|M.ulcerans_Agy99           APPAFLLLG------PDALMAYRHIAQRRDVEITDWEQLTAGTNLTP---
Mflv_0930|M.gilvum_PYR-GCK          PPPRRLVLG---------NSGYDAVIDALEQSLGDIRANETLSRSADFPT
MAB_3405|M.abscessus_ATCC_1997      VRRFMSKKTG--------TDRVFLDFDTSARTAYENRAGSSLGVTKPDGE
MLBr_01094|M.leprae_Br4923          KKKARVLVG--------PDAKVANVVVRFSGGAGYQRLFAQVASRLILNQ
                                                                                      

Mb1385|M.bovis_AF2122/97            --
Rv1350|M.tuberculosis_H37Rv         --
MSMEG_1628|M.smegmatis_MC2_155      --
Mvan_5466|M.vanbaalenii_PYR-1       --
MAV_4982|M.avium_104                SR
TH_3670|M.thermoresistible__bu      --
MMAR_1614|M.marinum_M               --
MUL_3423|M.ulcerans_Agy99           --
Mflv_0930|M.gilvum_PYR-GCK          --
MAB_3405|M.abscessus_ATCC_1997      --
MLBr_01094|M.leprae_Br4923          R-