For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSLLEGVRVVSFTHFLQGPSATALLADLGATVIKVEPPSGAFERSWSAPDAYLNGESVFFLLGNRNVESV VVDLKDPEWLEVVLRLLDEADVLIESFRPGVMDRLGLGWERLRERNSRLVYCSLSGYGSDGPYKDRPGQD VLLQSMAGIASVTGTADRPPTPVGASLVDQHGAVLGAFGILAALHGRDRTGQGTRVESNLLSAAMDLQIE PLSYFLNGFDGIRSATGISSPYYKSPYGVFATADGYLTLSLNALEKLAELFEDNWFRSIGEQSSYARREE INERVAVHLGKRSTEEWTTLLAAAQMWFAPVNGYAEVVDDPQVNHNGSVIEIQHPRAGAVKLLAHPITYD GQRPGVRSTPPELGGSNRKVLAELGYSTEHIDRLQAKVQK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0489 | - | - | 100% (390) | racemase |
| M. smegmatis MC2 155 | MSMEG_1154 | - | 3e-52 | 34.11% (387) | formyl-coenzyme A transferase |
| M. smegmatis MC2 155 | MSMEG_6773 | - | 2e-50 | 33.16% (389) | CaiB/BaiF family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 2e-44 | 32.23% (391) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_4465 | - | 2e-40 | 29.72% (397) | Formyl-CoA transferase |
| M. tuberculosis H37Rv | Rv3272 | - | 5e-45 | 32.48% (391) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0824 | - | 4e-46 | 33.60% (372) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_1267 | - | 1e-42 | 31.96% (388) | acyl-CoA transferase |
| M. avium 104 | MAV_4237 | - | 2e-44 | 33.16% (389) | YfdE protein |
| M. thermoresistible (build 8) | TH_3339 | - | 9e-48 | 32.40% (392) | PUTATIVE putative L-carnitine dehydratase/bile acid-inducible |
| M. ulcerans Agy99 | MUL_2621 | - | 4e-44 | 32.22% (388) | acyl-CoA transferase |
| M. vanbaalenii PYR-1 | Mvan_1855 | - | 1e-47 | 35.29% (374) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1267|M.marinum_M -------MPEGNPAKPLDGFRVLDFTQNVAGPLAGQVLADLGAEVIKVEA
MUL_2621|M.ulcerans_Agy99 -------MPEGNPAKPLDGFRVLDFTQNVAGPLAGQVLADLGAEVIKVEA
MAV_4237|M.avium_104 ---MPHETPNGKPPKPLDGFRVLDFTQNIAGPMAGQVLADLGAEVIKIEA
Mb3300|M.bovis_AF2122/97 -------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEA
Rv3272|M.tuberculosis_H37Rv -------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEA
MSMEG_0489|M.smegmatis_MC2_155 -------------MSLLEGVRVVSFTHFLQGPSATALLADLGATVIKVEP
Mflv_4465|M.gilvum_PYR-GCK -----------MTTGPLDGIRVIEVGTLISGPFAGRLLGDMGAEVIKVEP
TH_3339|M.thermoresistible__bu MTTEVETTATQPTTGPLHGIRVVEMGSLLAGPIVGQMMGDLGADVVKIED
MAB_0824|M.abscessus_ATCC_1997 -----------MTAAALDGLLVVDFSRVLAGPYATMMLGDFGAEVIKIER
Mvan_1855|M.vanbaalenii_PYR-1 -----------MTG-ALDGVVVVDFSRVLAGPYATMMLGDFGAEVIKVER
*.*. *:.. : ** . :: *:** *:*:*
MMAR_1267|M.marinum_M PGGEAARHITAVLPHRPPLATYFLPNNRGKKSVSVDLSTDTARRQILRLA
MUL_2621|M.ulcerans_Agy99 PGGEAARHITAVLPHRPPLATYFLPNNRGKKSVSVDLSTDTARRQILRLA
MAV_4237|M.avium_104 PIGEAARHITAVLPGRPPLATLFLPHNRGKKSVLADLRDDEAKQRILRLV
Mb3300|M.bovis_AF2122/97 PGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLA
Rv3272|M.tuberculosis_H37Rv PGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLA
MSMEG_0489|M.smegmatis_MC2_155 PSGAFERSWSAPDAYLNGESVFFLLGNRNVESVVVDLKDPEWLEVVLRLL
Mflv_4465|M.gilvum_PYR-GCK PGAPDPLRTWGQ-AELDGHHFFWTVHARNKKAVTLNLRVPEGRDLFLDLV
TH_3339|M.thermoresistible__bu PGKGDPLRQWGQ-NRPKGQSLWFSIVGRNKRSVTINLREPRGQELVRQLV
MAB_0824|M.abscessus_ATCC_1997 PVLGDDTRQWGPPYDSDGQATYFNSVNRNKQSVVLDLTSPDGQHRARELA
Mvan_1855|M.vanbaalenii_PYR-1 PGVGDDTRQWGPPYDSSGVATYFNAVNRNKRSVVLDLSTPDGRQQARDLV
* . : *. .:* :* *
MMAR_1267|M.marinum_M DTADVVLEGFRPGVMERMGLGPEDLRARNPKLIYARLSAFGGNGPHGTRP
MUL_2621|M.ulcerans_Agy99 DTADVVLEGFRPGVMERMGLGPEDLRARNPKLIYARLSAFGGNGPHGTRP
MAV_4237|M.avium_104 DTADVVLEGFRPGVMERMGLGPEELQGRNPRLVYARLSAYGGNGPEGSRP
Mb3300|M.bovis_AF2122/97 DTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRP
Rv3272|M.tuberculosis_H37Rv DTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRP
MSMEG_0489|M.smegmatis_MC2_155 DEADVLIESFRPGVMDRLGLGWERLRERNSRLVYCSLSGYGSDGPYKDRP
Mflv_4465|M.gilvum_PYR-GCK ERSDVIVENFRPGTLEKWNLGYDVLRERNRGIILVRVSGYGQTGPDAHKA
TH_3339|M.thermoresistible__bu AEADVLVENFRPGTMERWGLGYSDLAEINPRLVIVRVSGFGQDGPYASRP
MAB_0824|M.abscessus_ATCC_1997 GRADVVVENFRAGTMEKFGLGYQSLKQLNPGLIYCAITGFGR-GAGADLP
Mvan_1855|M.vanbaalenii_PYR-1 AGADIVVENFRPGTMERLGLGYEDLRAVRPDVIYCSITGFGR-GGGAALP
:*:::* **.*.::: .** . * . :: ::.:* * .
MMAR_1267|M.marinum_M GVDLMVAAEAGMTTGMPTPDGKPQIIPFQLVDNASGHVLAQAVLAALLNR
MUL_2621|M.ulcerans_Agy99 GVDLMVAAEAGMTTGMPTPDGKPQIIPFQLVDNASGHVLAQAVLAALLNR
MAV_4237|M.avium_104 GVDLMVAAESGMTTGMPTPTGKPQIIPFQLVDAASGHVLAQAVLAALLNR
Mb3300|M.bovis_AF2122/97 GIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHR
Rv3272|M.tuberculosis_H37Rv GIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHR
MSMEG_0489|M.smegmatis_MC2_155 GQDVLLQSMAGIASVTGTADRPPTPVGASLVDQHGAVLGAFGILAALHGR
Mflv_4465|M.gilvum_PYR-GCK GYASVAEAASGLRHMNGFPGGPPPRLALSLGDSLAGMFAAQGALAALYRR
TH_3339|M.thermoresistible__bu GYGAIGEAMGGLRYVVGDPSTPPSRVGISIGDTLAALFATIGALAALRER
MAB_0824|M.abscessus_ATCC_1997 GYDLLVQAVGGLMSVTGPDAAHPSKVGVALVDVLTALHALSGILAALSYR
Mvan_1855|M.vanbaalenii_PYR-1 GYDLLVQAVGGLMSVTGTEPGDPTKAGVALVDVLAGLHALSGILAALHHR
* : : .*: * : * . . **** *
MMAR_1267|M.marinum_M ERHGVADTVRVAMYDVAVGLQANQLTMHLNRPSSDAPKRPEQTPAGARRK
MUL_2621|M.ulcerans_Agy99 ERHGVADTVRVAMYDVAVGLQANQLTMHLNRPSSDAPKRPEQTPAGARRK
MAV_4237|M.avium_104 ERHGVADVVRVAMYDVAVSLQASQLTIHLNKPNADH-KPSDSASKPKRRK
Mb3300|M.bovis_AF2122/97 ERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQ-PKPEPAPKAKRRK
Rv3272|M.tuberculosis_H37Rv ERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQ-PKPEPAPKAKRRK
MSMEG_0489|M.smegmatis_MC2_155 DRTGQGTRVESNLLSAAMDLQIEPLSYFLNGFDGIRSATGISSP------
Mflv_4465|M.gilvum_PYR-GCK SVTGEGQIVDAALTESCLAVQESTIPDYDVGGVVRGPSGTRLEG------
TH_3339|M.thermoresistible__bu EISGRGQMVDSAIYEAVLGVMESLVPEWTVSGYQRERTGAILPK------
MAB_0824|M.abscessus_ATCC_1997 DRTGQGQRVDTDLMSVLLSSLVNQASGYLGAGVVPEALGNRHPS------
Mvan_1855|M.vanbaalenii_PYR-1 GRTGEGQRVDTDLLSVLLSSMVNQASGFLGAGVVPAMMGNRHPS------
* . * : . : .
MMAR_1267|M.marinum_M RVAFATQPSDAFRAADG-YLLISAYVPKHWQRLCEIIGRPDLLDDERFID
MUL_2621|M.ulcerans_Agy99 RVAFATQPSDAFRAADG-YLLISAYVPKHWQRLCEIIGQPDLLDDERFID
MAV_4237|M.avium_104 GVGFATQPSDAFKAADG-YLVISAYVPKHWDKLCEVIGRPDLRDDERFAD
Mb3300|M.bovis_AF2122/97 GVGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYLIGRPDLVEDQRFAE
Rv3272|M.tuberculosis_H37Rv GVGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYLIGRPDLVEDQRFAE
MSMEG_0489|M.smegmatis_MC2_155 ---YYKSPYGVFATADG-YLTLSLNALEKLAELFEDNWFRSIGEQSSYAR
Mflv_4465|M.gilvum_PYR-GCK -----IAPSNIYPTADGSWVVIAANQDTVFRRLCAAMGQPELATDERFAD
TH_3339|M.thermoresistible__bu -----IAPSNVYPTSDDTWILIAANQDTVFRRLAEAMGRPELAEDERYAT
MAB_0824|M.abscessus_ATCC_1997 -----IAPYQTFETADR-PIAIAVGNDKQFRLLVQALEMPRLARDDRFAT
Mvan_1855|M.vanbaalenii_PYR-1 -----IAPYQTFDTADR-PIAVAVGNDKQFRAFSTAIGQPELADDPRFVT
* : ::* : :: : : : :
MMAR_1267|M.marinum_M QRARAINYAELTEELESALAAKTAAQWVELLHEGGLMACLAYTWKQVVTT
MUL_2621|M.ulcerans_Agy99 QRARAINYAELTEELESALAAKTAAQWVELLHEGGLMACLAYTWKQVVTT
MAV_4237|M.avium_104 QRSRALNYPELTEELEKALAAKTADEWVRLLQAAGLMACHAYTWKQVVGT
Mb3300|M.bovis_AF2122/97 QRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDT
Rv3272|M.tuberculosis_H37Rv QRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDT
MSMEG_0489|M.smegmatis_MC2_155 RE-------EINERVAVHLGKRSTEEWTTLLAAAQMWFAPVNGYAEVVDD
Mflv_4465|M.gilvum_PYR-GCK HVARGRNQDEIDKIIGGWAAQRQPDEIISTLSEAGVISGPINTVAEVVED
TH_3339|M.thermoresistible__bu HVARGEHQAELDEIVAEFTRRHTAAEVEALMHKHNVPVGKIYRPKEMLAD
MAB_0824|M.abscessus_ATCC_1997 NPLRVRHRGELVRVLEQRLREKNADDWYDTLTAVGVPAGPINDIAEAFR-
Mvan_1855|M.vanbaalenii_PYR-1 NPARVANRDALCALIVPALKAHGADHWYAKLTTVGVPAGPINDLSEAFA-
. : : : . . : : : .
MMAR_1267|M.marinum_M PLFAENELALQVGS-GDDAVTVIRTPARYSSFSAVLA----EPPAATGEH
MUL_2621|M.ulcerans_Agy99 PLFAENELALQVDS-GDDAVTVIRTPARYSSFSAVLA----DPPPATGEH
MAV_4237|M.avium_104 PLFAENELALQVGE-GADAVTVIRTPARYSSFEAASAGWATDPPPALGQH
Mb3300|M.bovis_AF2122/97 PLFAESDLTLEVGR-GADTITVIRTPARYASFRAVVT----DPPPTAGEH
Rv3272|M.tuberculosis_H37Rv PLFAENDLTLEVGR-GADTITVIRTPARYASFRAVVT----DPPPTAGEH
MSMEG_0489|M.smegmatis_MC2_155 PQVNHNGSVIEIQHPRAGAVKLLAHPITYDGQRPGVR----STPPELGGS
Mflv_4465|M.gilvum_PYR-GCK PQLQARGMIADHWDERIGRNVKGPGVVPVLSETPGTIR--SAGSARPGQH
TH_3339|M.thermoresistible__bu PQFRARESITSVDHPVLG-EIQMQNVFPRLSRTRGSIR--WPGPG-LGEH
MAB_0824|M.abscessus_ATCC_1997 ---FAERLGLDVAVTVPGSPEPQVANPISMSKTPVVYR--NGPPR-----
Mvan_1855|M.vanbaalenii_PYR-1 ---FARGLGIDAAVQVPGSPAPQVANPVTMSATPVSYR--SGPPA-----
. . . .
MMAR_1267|M.marinum_M NET----LLGES----------------
MUL_2621|M.ulcerans_Agy99 NET----LLGES----------------
MAV_4237|M.avium_104 TEE----YLGAPQTAS------------
Mb3300|M.bovis_AF2122/97 NAV----FLARP----------------
Rv3272|M.tuberculosis_H37Rv NAV----FLARP----------------
MSMEG_0489|M.smegmatis_MC2_155 NRK----VLAELGYSTEHIDRLQAKVQK
Mflv_4465|M.gilvum_PYR-GCK NDEIYRDLLGRSAAELDKLQEEGVL---
TH_3339|M.thermoresistible__bu TDEVLR-QLGLSDEELQKLHDAGVV---
MAB_0824|M.abscessus_ATCC_1997 --------LGQSRA--------------
Mvan_1855|M.vanbaalenii_PYR-1 --------LGDSPIAEKP----------
*.