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MPHETPNGKPPKPLDGFRVLDFTQNIAGPMAGQVLADLGAEVIKIEAPIGEAARHITAVLPGRPPLATLF LPHNRGKKSVLADLRDDEAKQRILRLVDTADVVLEGFRPGVMERMGLGPEELQGRNPRLVYARLSAYGGN GPEGSRPGVDLMVAAESGMTTGMPTPTGKPQIIPFQLVDAASGHVLAQAVLAALLNRERHGVADVVRVAM YDVAVSLQASQLTIHLNKPNADHKPSDSASKPKRRKGVGFATQPSDAFKAADGYLVISAYVPKHWDKLCE VIGRPDLRDDERFADQRSRALNYPELTEELEKALAAKTADEWVRLLQAAGLMACHAYTWKQVVGTPLFAE NELALQVGEGADAVTVIRTPARYSSFEAASAGWATDPPPALGQHTEEYLGAPQTAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4237 | - | - | 100% (406) | YfdE protein |
| M. avium 104 | MAV_5126 | - | 5e-46 | 32.32% (396) | caib/baif family protein |
| M. avium 104 | MAV_4024 | - | 1e-42 | 32.85% (347) | caib/baif family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 1e-172 | 73.80% (397) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_4116 | - | 4e-46 | 34.00% (400) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv3272 | - | 1e-172 | 74.06% (397) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 5e-43 | 33.53% (346) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_1267 | - | 1e-177 | 78.54% (396) | acyl-CoA transferase |
| M. smegmatis MC2 155 | MSMEG_6773 | - | 2e-58 | 35.16% (384) | CaiB/BaiF family protein |
| M. thermoresistible (build 8) | TH_3905 | - | 8e-44 | 34.01% (347) | PUTATIVE Formyl-CoA transferase |
| M. ulcerans Agy99 | MUL_2621 | - | 1e-177 | 78.54% (396) | acyl-CoA transferase |
| M. vanbaalenii PYR-1 | Mvan_2229 | - | 2e-42 | 33.17% (404) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4116|M.gilvum_PYR-GCK ---------MAGPLEGIRVVELGVWVAGPAAGGILADWGADVVKIEPPTG
Mvan_2229|M.vanbaalenii_PYR-1 ---------MAGPLEGLRVVELGVWVAGPAAGGILADWGADVVKIEPPGG
Mb3300|M.bovis_AF2122/97 ----MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGG
Rv3272|M.tuberculosis_H37Rv ----MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGG
MMAR_1267|M.marinum_M ----MPEGNPAKPLDGFRVLDFTQNVAGPLAGQVLADLGAEVIKVEAPGG
MUL_2621|M.ulcerans_Agy99 ----MPEGNPAKPLDGFRVLDFTQNVAGPLAGQVLADLGAEVIKVEAPGG
MAV_4237|M.avium_104 MPHETPNGKPPKPLDGFRVLDFTQNIAGPMAGQVLADLGAEVIKIEAPIG
MSMEG_6773|M.smegmatis_MC2_155 -------------MRGLRVLDFTHVVAGPLCTMTLADLGADVVKIEPPAG
MAB_4651c|M.abscessus_ATCC_199 ---------MTGALDGIRVLELGTLIAGPFAGRLLGDMGAEVLKIEPPGA
TH_3905|M.thermoresistible__bu -------VTVTGPLDGIRVLELGTLIAGPFAGRLLGDMGAEVIKIELPGA
: *:**::: :*** . * * **:*:*:* * .
Mflv_4116|M.gilvum_PYR-GCK DPARTFGRMLGIPPQDRHHVSPPFQMDNRGKRSVVLDLASPDGRRSAREL
Mvan_2229|M.vanbaalenii_PYR-1 DPARTFGRMLGIQPQDRHHVSPPFQMDNRGKRSVVLDLATADGQSSAREL
Mb3300|M.bovis_AF2122/97 E----AARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRL
Rv3272|M.tuberculosis_H37Rv E----AARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRL
MMAR_1267|M.marinum_M E----AARHITAVLPHRPPLATYFLPNNRGKKSVSVDLSTDTARRQILRL
MUL_2621|M.ulcerans_Agy99 E----AARHITAVLPHRPPLATYFLPNNRGKKSVSVDLSTDTARRQILRL
MAV_4237|M.avium_104 E----AARHITAVLPGRPPLATLFLPHNRGKKSVLADLRDDEAKQRILRL
MSMEG_6773|M.smegmatis_MC2_155 E----IGRRIG--PPWRDGQSVIWQSVNRNKRSLTLDLKTPAGRRAARRM
MAB_4651c|M.abscessus_ATCC_199 P-----DPLRTWGQAEVDGHHVFWTVHARNKKAITLDLRTEAGRALFLDL
TH_3905|M.thermoresistible__bu P-----DPLRTWGQAELDGHHFFWTVHARNKKAITLNLREPAGRDVFLEL
: *.*::: :* .: :
Mflv_4116|M.gilvum_PYR-GCK IDGADVFVTNIRVGGLRRIGLDFEALAAANPRLVYGLITGYGTEGPDADR
Mvan_2229|M.vanbaalenii_PYR-1 LAGADVFLTNIRTGALRRIGLDFPAVAAANPQLIYGLITGYGSDGPDADR
Mb3300|M.bovis_AF2122/97 ADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSR
Rv3272|M.tuberculosis_H37Rv ADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSR
MMAR_1267|M.marinum_M ADTADVVLEGFRPGVMERMGLGPEDLRARNPKLIYARLSAFGGNGPHGTR
MUL_2621|M.ulcerans_Agy99 ADTADVVLEGFRPGVMERMGLGPEDLRARNPKLIYARLSAFGGNGPHGTR
MAV_4237|M.avium_104 VDTADVVLEGFRPGVMERMGLGPEELQGRNPRLVYARLSAYGGNGPEGSR
MSMEG_6773|M.smegmatis_MC2_155 ARQADVVVESFRPGVMTDLDLGYDTLASANPALVYCSISAFGQAGPASDR
MAB_4651c|M.abscessus_ATCC_199 VDKSDVIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQTGPDAHK
TH_3905|M.thermoresistible__bu VERSDIVVENFRPGTLERWDLGYDVLRSHNNRVILVRVSGYGQTGPDAHK
:*:.: :* * : .*. : * :: ::.:* ** . :
Mflv_4116|M.gilvum_PYR-GCK PAFDVAAFWARAGLAHLLTRPGDVPPFQRGGMGDHMAGMTLAGAICAALV
Mvan_2229|M.vanbaalenii_PYR-1 PAYDVAAFWARSGLAHLLTRPGEAPPFQRGGMGDHMAGMTLAGAVCAALV
Mb3300|M.bovis_AF2122/97 PGID-LVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALL
Rv3272|M.tuberculosis_H37Rv PGID-LVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALL
MMAR_1267|M.marinum_M PGVD-LMVAAEAGMTTGMPTPDGKPQIIPFQLVDNASGHVLAQAVLAALL
MUL_2621|M.ulcerans_Agy99 PGVD-LMVAAEAGMTTGMPTPDGKPQIIPFQLVDNASGHVLAQAVLAALL
MAV_4237|M.avium_104 PGVD-LMVAAESGMTTGMPTPTGKPQIIPFQLVDAASGHVLAQAVLAALL
MSMEG_6773|M.smegmatis_MC2_155 PGVD-GIMQAVTGLMSTLGEPESGPAKVQVPAADMVTGYLASIAVLAALH
MAB_4651c|M.abscessus_ATCC_199 AGYA-SVAEAASGLRHLNGFPGGPPPRMALSIGDTLAGMFAAQGALAALY
TH_3905|M.thermoresistible__bu AGYA-SVAEAASGLRHLNGFPGGPPPRLALSLGDTLAGMFAAQGAMAALY
.. * :*: * * * :* : . ***
Mflv_4116|M.gilvum_PYR-GCK ARARTGTGQLVSTSLYRQGAYTVSFDLTTFLITG---------NPIAIGQ
Mvan_2229|M.vanbaalenii_PYR-1 ARARTGAGQLVSTSLYRQGAYTVSFDLNTFLLTG---------HPIAIGQ
Mb3300|M.bovis_AF2122/97 HRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQ-PKPEPAPKAKR
Rv3272|M.tuberculosis_H37Rv HRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQ-PKPEPAPKAKR
MMAR_1267|M.marinum_M NRERHGVADTVRVAMYDVAVGLQANQLTMHLNRPSSDAPKRPEQTPAGAR
MUL_2621|M.ulcerans_Agy99 NRERHGVADTVRVAMYDVAVGLQANQLTMHLNRPSSDAPKRPEQTPAGAR
MAV_4237|M.avium_104 NRERHGVADVVRVAMYDVAVSLQASQLTIHLNKPNADH-KPSDSASKPKR
MSMEG_6773|M.smegmatis_MC2_155 EVRDGGRGQHLDVSLYNATILLQQIGFTSYLASG-----------AEPQR
MAB_4651c|M.abscessus_ATCC_199 RRTVTGRGQVVDAALTESCLAVQESTIPDYDVGR-----------VVRGP
TH_3905|M.thermoresistible__bu RRTVTGEGQVVDAALTEACLAVQESTIPDYDIGG-----------VVRGP
* .: : .:: : .
Mflv_4116|M.gilvum_PYR-GCK REVMGNPCMNNYSAADGKR-FWLVGLQGDRHWPALCAAVQRPDWPTDERF
Mvan_2229|M.vanbaalenii_PYR-1 RETMGNPCMNNYTAADGRR-FWLVGLQGERHWPALCAAVERTDWLSDERF
Mb3300|M.bovis_AF2122/97 RKGVGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYLIGRPDLVEDQRF
Rv3272|M.tuberculosis_H37Rv RKGVGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYLIGRPDLVEDQRF
MMAR_1267|M.marinum_M RKRVAFATQPSDAFRAADG-YLLISAYVPKHWQRLCEIIGRPDLLDDERF
MUL_2621|M.ulcerans_Agy99 RKRVAFATQPSDAFRAADG-YLLISAYVPKHWQRLCEIIGQPDLLDDERF
MAV_4237|M.avium_104 RKGVGFATQPSDAFKAADG-YLVISAYVPKHWDKLCEVIGRPDLRDDERF
MSMEG_6773|M.smegmatis_MC2_155 LGSAAPYAAPNEALPTADG-WIMIAAYDPARWNALCDALGAPDLSSDARF
MAB_4651c|M.abscessus_ATCC_199 SGTRLEGIAPSNIYQSADGSWVVIAANQDTVFRRLCEAMGRPELSSDARF
TH_3905|M.thermoresistible__bu SGTRLEGIAPSNIYRSADGSWVVIAANQDTVFRRLCAAMGRPELATDDRF
. . : ::. : ** : .: * **
Mflv_4116|M.gilvum_PYR-GCK ATGRARAANAAELIAELDAIFARRTLAEWTEVFAAHPDLFWSPINSMEDV
Mvan_2229|M.vanbaalenii_PYR-1 ATGRARAANAVELIAELDTVFAGKTLEEWAEVFSGQPDLFWSPINSMEDV
Mb3300|M.bovis_AF2122/97 AEQRSRSINYAELTAELELALASKTATEWVQLLQAN-GLMACLAHTWKQV
Rv3272|M.tuberculosis_H37Rv AEQRSRSINYAELTAELELALASKTATEWVQLLQAN-GLMACLAHTWKQV
MMAR_1267|M.marinum_M IDQRARAINYAELTEELESALAAKTAAQWVELLHEG-GLMACLAYTWKQV
MUL_2621|M.ulcerans_Agy99 IDQRARAINYAELTEELESALAAKTAAQWVELLHEG-GLMACLAYTWKQV
MAV_4237|M.avium_104 ADQRSRALNYPELTEELEKALAAKTADEWVRLLQAA-GLMACHAYTWKQV
MSMEG_6773|M.smegmatis_MC2_155 ATNDDRVRNRPALRTELGRLLRARTTQVWLDVLSAR-DILCAPVNGYGQV
MAB_4651c|M.abscessus_ATCC_199 ANHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAA-GVIAGPINTVADV
TH_3905|M.thermoresistible__bu ATHTARGRNQDELDKIIADWAAERAPGEIIDTLNAA-GVIAGPINTVAEV
* * * : : : .:: :*
Mflv_4116|M.gilvum_PYR-GCK IGDEQFHAAGGIVYVP------------DDEAGSVPMVATPADFHGTPAQ
Mvan_2229|M.vanbaalenii_PYR-1 IADEQFHASGGIVYVP------------DSDGGAVPMVATPADFHGTPAE
Mb3300|M.bovis_AF2122/97 VDTPLFAESDLTLEVG-------------RGADTITVIRTPARYASFRAV
Rv3272|M.tuberculosis_H37Rv VDTPLFAENDLTLEVG-------------RGADTITVIRTPARYASFRAV
MMAR_1267|M.marinum_M VTTPLFAENELALQVG-------------SGDDAVTVIRTPARYSSFSAV
MUL_2621|M.ulcerans_Agy99 VTTPLFAENELALQVD-------------SGDDAVTVIRTPARYSSFSAV
MAV_4237|M.avium_104 VGTPLFAENELALQVG-------------EGADAVTVIRTPARYSSFEAA
MSMEG_6773|M.smegmatis_MC2_155 VASPEYAASGLHRPIGPIDTPGLVLGPSQPAAPPDTAPPAPGQHSAEVLA
MAB_4651c|M.abscessus_ATCC_199 VQDPQLKAREMLVEHFDERLG-----RSVLGPGVVPVLSESPGGVRNAGP
TH_3905|M.thermoresistible__bu VEDPQLRARGMIADHFDERIG-----RNVKGPGVVPVLSESPGTIRNAGP
: . .
Mflv_4116|M.gilvum_PYR-GCK IR----CSAPELGAHTEEVLTELAQRTNRST
Mvan_2229|M.vanbaalenii_PYR-1 VR----CAAPELGEHTEEVLAELAQWTNRSM
Mb3300|M.bovis_AF2122/97 VT----DPPPTAGEHNAVFLARP--------
Rv3272|M.tuberculosis_H37Rv VT----DPPPTAGEHNAVFLARP--------
MMAR_1267|M.marinum_M LA----EPPAATGEHNETLLGES--------
MUL_2621|M.ulcerans_Agy99 LA----DPPPATGEHNETLLGES--------
MAV_4237|M.avium_104 SAGWATDPPPALGQHTEEYLGAPQTAS----
MSMEG_6773|M.smegmatis_MC2_155 EYGLSEDEVAALIEHGVVNDVAPSRAAS---
MAB_4651c|M.abscessus_ATCC_199 ARPGQDNDDVYVGLLGKSAQDIERLRAEGVL
TH_3905|M.thermoresistible__bu ARPGQHNEEIYTGLLGKTAAELRQLRAQGVI