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TGALDGVVVVDFSRVLAGPYATMMLGDFGAEVIKVERPGVGDDTRQWGPPYDSSGVATYFNAVNRNKRSV VLDLSTPDGRQQARDLVAGADIVVENFRPGTMERLGLGYEDLRAVRPDVIYCSITGFGRGGGAALPGYDL LVQAVGGLMSVTGTEPGDPTKAGVALVDVLAGLHALSGILAALHHRGRTGEGQRVDTDLLSVLLSSMVNQ ASGFLGAGVVPAMMGNRHPSIAPYQTFDTADRPIAVAVGNDKQFRAFSTAIGQPELADDPRFVTNPARVA NRDALCALIVPALKAHGADHWYAKLTTVGVPAGPINDLSEAFAFARGLGIDAAVQVPGSPAPQVANPVTM SATPVSYRSGPPALGDSPIAEKP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1855 | - | - | 100% (374) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. vanbaalenii PYR-1 | Mvan_1895 | - | 8e-57 | 39.44% (322) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. vanbaalenii PYR-1 | Mvan_1126 | - | 7e-54 | 37.14% (377) | L-carnitine dehydratase/bile acid-inducible protein F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 4e-44 | 34.29% (382) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_4465 | - | 1e-56 | 37.40% (369) | Formyl-CoA transferase |
| M. tuberculosis H37Rv | Rv3272 | - | 6e-44 | 34.29% (382) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0824 | - | 1e-154 | 72.33% (365) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_1494 | - | 5e-57 | 37.77% (368) | hypothetical protein MMAR_1494 |
| M. avium 104 | MAV_1892 | - | 4e-57 | 38.61% (373) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. smegmatis MC2 155 | MSMEG_6689 | - | 1e-177 | 82.87% (362) | CAIB/BAIF family protein |
| M. thermoresistible (build 8) | TH_3339 | - | 3e-60 | 40.00% (325) | PUTATIVE putative L-carnitine dehydratase/bile acid-inducible |
| M. ulcerans Agy99 | MUL_2446 | - | 6e-57 | 37.77% (368) | hypothetical protein MUL_2446 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1855|M.vanbaalenii_PYR-1 ------------MTGALDGVVVVDFSRVLAGPYATMMLGDFGAEVIKVER
MSMEG_6689|M.smegmatis_MC2_155 -----------MSAAALEGVVVADFSRVLAGPYATMMLADFGAEVIKIER
MAB_0824|M.abscessus_ATCC_1997 -----------MTAAALDGLLVVDFSRVLAGPYATMMLGDFGAEVIKIER
MAV_1892|M.avium_104 -------------MGPLSGVTVVSLEQAVAAPYATRQLADLGARVIKVER
MMAR_1494|M.marinum_M ----------MTEPGALDGIRVLELGTLIAGPFAGRLLGDMGADVIKVEA
MUL_2446|M.ulcerans_Agy99 ----------MTEPGALDGIRVLELGTLIAGPFAGRLLGDMGADVIKVEA
Mflv_4465|M.gilvum_PYR-GCK ----------MTT-GPLDGIRVIEVGTLISGPFAGRLLGDMGAEVIKVEP
TH_3339|M.thermoresistible__bu MTTEVETTATQPTTGPLHGIRVVEMGSLLAGPIVGQMMGDLGADVVKIED
Mb3300|M.bovis_AF2122/97 -------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEA
Rv3272|M.tuberculosis_H37Rv -------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEA
.* *. * .. ::.* . : *:** *:*:*
Mvan_1855|M.vanbaalenii_PYR-1 PGVGDDTRQWGPPYDSSGVATYFNAVNRNKRSVVLDLSTPDGRQQARDLV
MSMEG_6689|M.smegmatis_MC2_155 PGTGDDTRQWGPPYDSTGVATYFNSVNRNKRSVALDLGSTEGREQARELI
MAB_0824|M.abscessus_ATCC_1997 PVLGDDTRQWGPPYDSDGQATYFNSVNRNKQSVVLDLTSPDGQHRARELA
MAV_1892|M.avium_104 PDGGDFAR--GYDHSVHGDSSYFVWLNRGKESLTLDLKTLEGQRILRQLL
MMAR_1494|M.marinum_M PGAPDPLRTWGQAE-VDGHHVFWTVHARNKRAITLDLRRPQGRELFLELV
MUL_2446|M.ulcerans_Agy99 PGAPDPLRTWGQAE-VDGHHVFWTVHARNKRAITLDLRRPQGRELFLELV
Mflv_4465|M.gilvum_PYR-GCK PGAPDPLRTWGQAE-LDGHHFFWTVHARNKKAVTLNLRVPEGRDLFLDLV
TH_3339|M.thermoresistible__bu PGKGDPLRQWGQNR-PKGQSLWFSIVGRNKRSVTINLREPRGQELVRQLV
Mb3300|M.bovis_AF2122/97 PGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLA
Rv3272|M.tuberculosis_H37Rv PGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLA
* : . :: *.*.::.::* .: *
Mvan_1855|M.vanbaalenii_PYR-1 AGADIVVENFRPGTMERLGLGYEDLRAVRPDVIYCSITGFG-RGGGAALP
MSMEG_6689|M.smegmatis_MC2_155 RRADIVVENFRPGTMEKLGLGYDDVRAIRPDVIYCSITGFG-HGGGAALP
MAB_0824|M.abscessus_ATCC_1997 GRADVVVENFRAGTMEKFGLGYQSLKQLNPGLIYCAITGFG-RGAGADLP
MAV_1892|M.avium_104 ANSDVLVQNLGPGATTRLSLDATTLTPEYPRLIVCDITGYGGTGPWRDRK
MMAR_1494|M.marinum_M DKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQTGPDAHKA
MUL_2446|M.ulcerans_Agy99 DKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQTGPDAHKA
Mflv_4465|M.gilvum_PYR-GCK ERSDVIVENFRPGTLEKWNLGYDVLRERNRGIILVRVSGYGQTGPDAHKA
TH_3339|M.thermoresistible__bu AEADVLVENFRPGTMERWGLGYSDLAEINPRLVIVRVSGFGQDGPYASRP
Mb3300|M.bovis_AF2122/97 DTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRP
Rv3272|M.tuberculosis_H37Rv DTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRP
:*:::: : .*: : .*. : :: ::.:* *
Mvan_1855|M.vanbaalenii_PYR-1 GYDLLVQAVGGLMSVTGTEPGDPTKAGVALVDVLAGLHALSGILAALHHR
MSMEG_6689|M.smegmatis_MC2_155 GYDLLVQAVGGLMSVTGTEPGDPTKAGVALVDVLAGMHALSGILVALAHR
MAB_0824|M.abscessus_ATCC_1997 GYDLLVQAVGGLMSVTGPDAAHPSKVGVALVDVLTALHALSGILAALSYR
MAV_1892|M.avium_104 AYDLLVQAEAGLLSVTGSG-DEVARTGVSIADIAAGMFAFSGILTALYVR
MMAR_1494|M.marinum_M GYASVAEAASGLRHLNGFPGGPPPRLALSLGDSLAGMFGAQGALAALYRR
MUL_2446|M.ulcerans_Agy99 GYASVAEAASGLRHLNGFPGGPPPRLALSLGDSLAGMFGPQGALAALYRR
Mflv_4465|M.gilvum_PYR-GCK GYASVAEAASGLRHMNGFPGGPPPRLALSLGDSLAGMFAAQGALAALYRR
TH_3339|M.thermoresistible__bu GYGAIGEAMGGLRYVVGDPSTPPSRVGISIGDTLAALFATIGALAALRER
Mb3300|M.bovis_AF2122/97 GIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHR
Rv3272|M.tuberculosis_H37Rv GIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHR
. : * .*: . : * :. . *.** *
Mvan_1855|M.vanbaalenii_PYR-1 GRTGEGQRVDTDLLSVLLSSMVNQASGFLGAGVVPAMMGNRHPS------
MSMEG_6689|M.smegmatis_MC2_155 DRTGEGQRVDTNLFSVLLSSMVNQASGYLGAGVVPGIMGNRHPS------
MAB_0824|M.abscessus_ATCC_1997 DRTGQGQRVDTDLMSVLLSSLVNQASGYLGAGVVPEALGNRHPS------
MAV_1892|M.avium_104 ATTGDVRPVSVSLFESLVELVSQPAYYAHYGGTAPPRTGARHAT------
MMAR_1494|M.marinum_M SVTGTGQVVDVALTESCLALQESTISDYDVGGVVRGPSGTRLEG------
MUL_2446|M.ulcerans_Agy99 SVTGTGQVVDVALTESCLALQESTISDYDVGGVVRGPSGTRLKG------
Mflv_4465|M.gilvum_PYR-GCK SVTGEGQIVDAALTESCLAVQESTIPDYDVGGVVRGPSGTRLEG------
TH_3339|M.thermoresistible__bu EISGRGQMVDSAIYEAVLGVMESLVPEWTVSGYQRERTGAILPK------
Mb3300|M.bovis_AF2122/97 ERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKG
Rv3272|M.tuberculosis_H37Rv ERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKG
.* *. : . : . .
Mvan_1855|M.vanbaalenii_PYR-1 ----IAPYQTFDTADR-PIAVAVGNDKQFR-AFSTAIGQPELADDPRFVT
MSMEG_6689|M.smegmatis_MC2_155 ----ITPYQTFDTADR-PIAIAVGNDKQFR-AFAAVIGSPELADDPRFST
MAB_0824|M.abscessus_ATCC_1997 ----IAPYQTFETADR-PIAIAVGNDKQFR-LLVQALEMPRLARDDRFAT
MAV_1892|M.avium_104 ----IAPYGPFTAGDGGTVLLAVQNQREWRRLCDEVLATPGLCEDPRFVT
MMAR_1494|M.marinum_M ----IAPSNIYRSADESWVVIAANQDTVFT-RLCQAMGCPELATDDRFAT
MUL_2446|M.ulcerans_Agy99 ----IAPSNIYRSADESWVVIAANQDTVFT-RLCQAMGCPELATDDRFAT
Mflv_4465|M.gilvum_PYR-GCK ----IAPSNIYPTADGSWVVIAANQDTVFR-RLCAAMGQPELATDERFAD
TH_3339|M.thermoresistible__bu ----IAPSNVYPTSDDTWILIAANQDTVFR-RLAEAMGRPELAEDERYAT
Mb3300|M.bovis_AF2122/97 VGFATQPSDAFRTADG-YIVISAYVPKHWQ-KLCYLIGRPDLVEDQRFAE
Rv3272|M.tuberculosis_H37Rv VGFATQPSDAFRTADG-YIVISAYVPKHWQ-KLCYLIGRPDLVEDQRFAE
* : :.* : ::. : : * * * *:
Mvan_1855|M.vanbaalenii_PYR-1 NPARVANRDALCALIVPALKAHGADHWYAKLTTVGVPAGPINDLSEAFAF
MSMEG_6689|M.smegmatis_MC2_155 NPQRVAHRDVLCPLIEAALKAKGADHWYHELTAVGVPAGPINDLSEAFAF
MAB_0824|M.abscessus_ATCC_1997 NPLRVRHRGELVRVLEQRLREKNADDWYDTLTAVGVPAGPINDIAEAFRF
MAV_1892|M.avium_104 NPDRVTHRDELEAIIHAAIASMTADELAHRLEAAGIANARMNDVETLWSH
MMAR_1494|M.marinum_M HRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPINTVAEVVKD
MUL_2446|M.ulcerans_Agy99 HRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPINTVAEVVKD
Mflv_4465|M.gilvum_PYR-GCK HVARGRNQDEIDKIIGGWAAQRQPDEIISTLSEAGVISGPINTVAEVVED
TH_3339|M.thermoresistible__bu HVARGEHQAELDEIVAEFTRRHTAAEVEALMHKHNVPVGKIYRPKEMLAD
Mb3300|M.bovis_AF2122/97 QRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDT
Rv3272|M.tuberculosis_H37Rv QRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDT
: * : : : . . : .:
Mvan_1855|M.vanbaalenii_PYR-1 ARGLGID--AAVQVPGSPAPQVAN--PVTMSATPVSYRSGPPALGDSPIA
MSMEG_6689|M.smegmatis_MC2_155 AEELGIE--AVVQMPDGPTPQVAN--PITLSATPVTYRNSPPPLS-----
MAB_0824|M.abscessus_ATCC_1997 AERLGLD--VAVTVPGSPEPQVAN--PISMSKTPVVYRNGPPRLGQSRA-
MAV_1892|M.avium_104 PVLAGRDRWREVRAPGGAIEALLP--PATLRDVEPQLGDVPGLAAHSRMI
MMAR_1494|M.marinum_M RQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGPARPGQHND
MUL_2446|M.ulcerans_Agy99 RQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGPARPGQHND
Mflv_4465|M.gilvum_PYR-GCK PQLQARGMIADHWDERIGRNVKGPGVVPVLSETPGTIRSAGSARPGQHND
TH_3339|M.thermoresistible__bu PQFRARESITSVDHPVLG-EIQMQNVFPRLSRTRGSIRWPGPG-LGEHTD
Mb3300|M.bovis_AF2122/97 PLFAESDLTLEVGRGADTITVIRT--PARYASFRAVVTDPPPTAGEHNAV
Rv3272|M.tuberculosis_H37Rv PLFAENDLTLEVGRGADTITVIRT--PARYASFRAVVTDPPPTAGEHNAV
Mvan_1855|M.vanbaalenii_PYR-1 EKP-----------------------
MSMEG_6689|M.smegmatis_MC2_155 --------------------------
MAB_0824|M.abscessus_ATCC_1997 --------------------------
MAV_1892|M.avium_104 LRELGYTNEAIADLVRSGVTTVASDH
MMAR_1494|M.marinum_M DVYIGLLGKSIEELEQLRAEEVL---
MUL_2446|M.ulcerans_Agy99 DVYIGLLGKSIEELEQLRAVEVL---
Mflv_4465|M.gilvum_PYR-GCK EIYRDLLGRSAAELDKLQEEGVL---
TH_3339|M.thermoresistible__bu EVLR-QLGLSDEELQKLHDAGVV---
Mb3300|M.bovis_AF2122/97 FLARP---------------------
Rv3272|M.tuberculosis_H37Rv FLARP---------------------