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MTLPQLPPGRTFEVRAVDGVRLHAQTFGPEDGYPIVFAHGITCAIEVWAHQIADLAGDYRVIAYDHRGHG RSETPRGRNRYSLNHLAADLDAVLDATLRPGERAVIAGHSMGGIAITSWAQRYPSRVQTCADGVALINTS TGDLLRDVQLAQVPTRLSTTRIRTAGTILKTFGSTPVPKLADAANRRFVAHLAVGRDADPWVADFVYRLF ATTPPTGRGAWGRVLVDNLGPKHIPLHNLTVPTLVIGSAQDRLLPINASRRIADTVPNLAAFVELRGGHC GILERPDEVNAQLRKLAEAVISPQRLNS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2036 | - | - | 100% (308) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_1576 | - | 5e-22 | 30.86% (324) | alpha/beta hydrolase fold |
| M. smegmatis MC2 155 | MSMEG_1897 | pcaD | 6e-16 | 27.70% (278) | 3-oxoadipate enol-lactonase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3196c | hpx | 5e-93 | 58.89% (287) | non-Heme haloperoxidase Hpx |
| M. gilvum PYR-GCK | Mflv_4502 | - | 1e-117 | 66.45% (304) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3171c | hpx | 1e-93 | 59.23% (287) | non-Heme haloperoxidase Hpx |
| M. leprae Br4923 | MLBr_02269 | - | 4e-13 | 27.55% (265) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3738c | - | 4e-15 | 28.76% (306) | putative hydrolase alpha/beta fold |
| M. marinum M | MMAR_1388 | hpx | 2e-91 | 56.27% (295) | non-heme haloperoxidase Hpx |
| M. avium 104 | MAV_4061 | - | 9e-97 | 60.34% (295) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_0684 | hpx | 1e-110 | 65.13% (304) | POSSIBLE NON-HEME HALOPEROXIDASE HPX |
| M. ulcerans Agy99 | MUL_2488 | hpx | 2e-91 | 56.27% (295) | non-heme haloperoxidase Hpx |
| M. vanbaalenii PYR-1 | Mvan_1865 | - | 1e-115 | 67.12% (295) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3196c|M.bovis_AF2122/97 --------------------------------------------------
Rv3171c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1388|M.marinum_M ------------------------MSARKATDGKAHTKAPAALPDVLPPS
MUL_2488|M.ulcerans_Agy99 ------------------------MSARKATDGKAHTKASAALPDVLPPS
MAV_4061|M.avium_104 ------------------------MRAR-----------TDPFPDRLPPS
Mflv_4502|M.gilvum_PYR-GCK ---------------------------MARSSSTRSRRAGSGPAVELPRG
Mvan_1865|M.vanbaalenii_PYR-1 ---------------------------MAPGTSTRSRSRGFAPAQALPPG
TH_0684|M.thermoresistible__bu -------------------------------------------VEQMPPG
MSMEG_2036|M.smegmatis_MC2_155 -----------------------------------------MTLPQLPPG
MAB_3738c|M.abscessus_ATCC_199 MSNKSNAWLAGVAGLGAVVAVAGVGTARSIGRRRFDDPYRGENFDLLQTD
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
Mb3196c|M.bovis_AF2122/97 --MTVRAADGTPLHTQVFGPPHG-YPIVLTHGFVCAIRAWA-YQIADLAG
Rv3171c|M.tuberculosis_H37Rv --MTVRAADGTPLHTQVFGPPHG-YPIVLTHGFVCAIRAWA-YQIADLAG
MMAR_1388|M.marinum_M RSLTVRAADGTALHTQVFGPADG-YPIVLTHGFVCSIRAWA-YQIADLAT
MUL_2488|M.ulcerans_Agy99 RSLTVRAADGTALHTQVFGPADG-YPIVLTHGFVCSIRAWA-YQIADLAT
MAV_4061|M.avium_104 RTVTVRAVDGTRLHAQVFGPPDG-YPIVLTHGITCAIRAWA-YQIDDLAR
Mflv_4502|M.gilvum_PYR-GCK RVVDVRSRDGVRLHAEVFGPEDG-YPIVLAHGITCAIPVWA-HQIADLSR
Mvan_1865|M.vanbaalenii_PYR-1 RIVDVRSKDGVRLHAEVFGPEDG-YPIVLAHGITCSLRVWA-YQIAELAR
TH_0684|M.thermoresistible__bu RVVSVTAPDGVRLHAEVFGPADA-PPIVLAHGITCAIRVWA-HQIAELAD
MSMEG_2036|M.smegmatis_MC2_155 RTFEVRAVDGVRLHAQTFGPEDG-YPIVFAHGITCAIEVWA-HQIADLAG
MAB_3738c|M.abscessus_ATCC_199 RGSIVTTDDGVPLAVREVGPSNAPLTVVFVHGFCLQMASFH-FQRRELAS
MLBr_02269|M.leprae_Br4923 ---------MINLAYEDRGTGEP---VVFIAGRGGAGRTWQPHQVPAFLA
* . *. . :*: * : .* :
Mb3196c|M.bovis_AF2122/97 ----DYRVIAFDHRGHGRSGVP-RRGAYSLNHLAADLDSVLDATLAPRER
Rv3171c|M.tuberculosis_H37Rv ----DYRVIAFDHRGHGRSGVP-RRGAYSLNHLAADLDSVLDATLAPRER
MMAR_1388|M.marinum_M ----DYRVIAFDHRGHGRSGIP-RRGGYTLEHLASDLDSVLDATLAPHER
MUL_2488|M.ulcerans_Agy99 ----DYRVIAFDHRGHGRSGIP-RRGGYTLEHLASDLDSVLDATLAPHER
MAV_4061|M.avium_104 ----DYRVIAYDHRGHGRSGVP-KATGYSLKHLAADLDSVLEATLAPHER
Mflv_4502|M.gilvum_PYR-GCK ----DHRVIAYDHRGHGRSGVPPRRGGYSLDYLASDLDAVLEATMAPGER
Mvan_1865|M.vanbaalenii_PYR-1 ----DHRVIAFDHRGHGRSAIPPRRGGYSLDYLAGDLDAVLEATLAPGER
TH_0684|M.thermoresistible__bu ----DYRVIAFDHRGHGRSSVPRRRWQYSLDHLASDLDAVLDATLDPGER
MSMEG_2036|M.smegmatis_MC2_155 ----DYRVIAYDHRGHGRSETPRGRNRYSLNHLAADLDAVLDATLRPGER
MAB_3738c|M.abscessus_ATCC_199 RWGDNVRMVFYDQRGHGRSGLP-APASCTVGQLGDDLESVLR-VLVPRGN
MLBr_02269|M.leprae_Br4923 AG---YRVITFDNRGIGATENT---EGFTTQTMVADTAVLIESLGAVP--
*:: :*:** * : . : : * ::
Mb3196c|M.bovis_AF2122/97 AVVAGHSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSV
Rv3171c|M.tuberculosis_H37Rv AVVAGHSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSV
MMAR_1388|M.marinum_M ALIAGHSMGGIAISAWSERYRHKVHRRADAVALINTATGDLLRKIRMLSV
MUL_2488|M.ulcerans_Agy99 ALIAGHSMGGIAISAWSERYRHKVHRRADAVALINTATGDLLRKIRMLSV
MAV_4061|M.avium_104 AVLAGHSMGGITIAAWSNRYRHKVSRRADAVALINTTSGELIRQVQLLSV
Mflv_4502|M.gilvum_PYR-GCK AVIAGHSMGGIAISSWSERLPHRVAERADGVALINTTTGDLLRNVNLLPV
Mvan_1865|M.vanbaalenii_PYR-1 AVIAGHSMGGIAISSWSERLPHRVEQRADAVALINTTTGDLLRNVNLLPV
TH_0684|M.thermoresistible__bu AVIAGHSMGGIAISSWAERYPERVSERAAAVALINTTTGDLLHNVQLLPV
MSMEG_2036|M.smegmatis_MC2_155 AVIAGHSMGGIAITSWAQRYPSRVQTCADGVALINTSTGDLLRDVQLAQV
MAB_3738c|M.abscessus_ATCC_199 AVLVGHSMGGMTVLAHARRHPEQYGRRIVGVGLIASAAEGLS-HTAIGEG
MLBr_02269|M.leprae_Br4923 ARIVGVSMGSFIAQELMVARPELVR-----AAVLMATRGRLDRTRQFFHA
* :.* ***.: ..:: :: * :
Mb3196c|M.bovis_AF2122/97 PRELSPVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAADADPSAT
Rv3171c|M.tuberculosis_H37Rv PRELSPVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAADADPSAT
MMAR_1388|M.marinum_M PRELSAARDFAGRGLINAFGGFPLPSAVRIPTQYLIAMMAVGADAHPTAA
MUL_2488|M.ulcerans_Agy99 PRELSAARDFAGRGLINAFGGFPLPSAVRIPTQYLIAMMAVGADAHPTAA
MAV_4061|M.avium_104 PPGLSPARVLAGRVLIGAFAGFAVPRAARVPSRHLVALLATGRDADPAIA
Mflv_4502|M.gilvum_PYR-GCK PARFADARVRAAGGVIRTFGGTSMVRVADLPSRRFVSMIAVGRDADPAIA
Mvan_1865|M.vanbaalenii_PYR-1 PPALADVRVRAAGEVLRRFGGVPLVRAVDRPNRRFVSSIAVGRDADPAIA
TH_0684|M.thermoresistible__bu PDRFAAVRVRTASAVIKTVAGMP-ARLAAVPSRYVVSMMAVGRDADPAIT
MSMEG_2036|M.smegmatis_MC2_155 PTRLSTTRIRTAGTILKTFGSTPVPKLADAANRRFVAHLAVGRDADPWVA
MAB_3738c|M.abscessus_ATCC_199 LRNPALRVLRTAVHYAPGPAHHGRGAIKSLVGPVLQAASYGGHRVSPTLV
MLBr_02269|M.leprae_Br4923 AEAEFHD------------SGIQLPSGYNAKVRLLENLSRKTLNDDVAVA
. . .
Mb3196c|M.bovis_AF2122/97 RLVYELFTQMSAAGRGGCAKMLVEEVGSAHLNLDGLTVPTLVIGGVRDRL
Rv3171c|M.tuberculosis_H37Rv RLVYELFTQTSAAGRGGCAKMLVEEVGSAHLNLDGLTVPTLVIGGVRDRL
MMAR_1388|M.marinum_M RLLYELFAQTSAAGRGGCARMLVGEVGSRHISLDGLTVPTLVIGSERDRL
MUL_2488|M.ulcerans_Agy99 RLLYELFAQTSAAGRGGCARMLVGEVGSRHISLDGLTVPTLVIGSERDRL
MAV_4061|M.avium_104 RLVYELFENTAPAGRAGCARALVSALGSRYLDLAGLTVPTLVIGSERDRL
Mflv_4502|M.gilvum_PYR-GCK DFVFELFHRTPPAGRGGWARVLVDHLGPRHIGLDNLTVPALVIGSTHDRL
Mvan_1865|M.vanbaalenii_PYR-1 DFVFELFNSTSPAGRGGWARVLVDHLGPRHIALKNLTVPTLVIGSTKDRL
TH_0684|M.thermoresistible__bu NFVHELFTETPPAARDGWARTLVDAMGPRHIGLHNLTVPTLVIGSDRDRL
MSMEG_2036|M.smegmatis_MC2_155 DFVYRLFATTPPTGRGAWGRVLVDNLGPKHIPLHNLTVPTLVIGSAQDRL
MAB_3738c|M.abscessus_ATCC_199 KFSERMIHQTPVTTIVDFLRALEQHDETAALPTIAP-LPSLVICGDTDML
MLBr_02269|M.leprae_Br4923 DWIAMFNMWPIKSTPGLRCQTDVAPQNNRLPAYRSIAAPVLVIGFAEDVV
: : : * *** * :
Mb3196c|M.bovis_AF2122/97 TPISQSR----RIARTAPNVVGLVELPGGHCSMLERHQEVNSHLRALAES
Rv3171c|M.tuberculosis_H37Rv TPISQSR----RIARTAPNVVGLVELPGGHCSMLERHQEVNSHLRALAES
MMAR_1388|M.marinum_M TPISQTR----KIASTAPNVFDLVELPGGHCSMLEQHHEVNRHLRTLVDS
MUL_2488|M.ulcerans_Agy99 TPISQTR----KIASTAPNVFDLVELPGGHCSMLEQHHEVNRHLRTLVDS
MAV_4061|M.avium_104 TPIRQSR----RIAEGLPNLIELVELPGGHCSMLEHPREVNRRLRALAES
Mflv_4502|M.gilvum_PYR-GCK LPVSSAR----HIASAAPNLARFVELAGGHCAILERPEEVNQQLRWLVDS
Mvan_1865|M.vanbaalenii_PYR-1 LPMASAR----RIAATAPNLARFVEVPGGHCAILERPDDVNDHLRWLVRS
TH_0684|M.thermoresistible__bu LPLVSSR----RIAEAAPNLFDFVELPGGHCAILECPDRVNDHLRALAAA
MSMEG_2036|M.smegmatis_MC2_155 LPINASR----RIADTVPNLAAFVELRGGHCGILERPDEVNAQLRKLAEA
MAB_3738c|M.abscessus_ATCC_199 TPHTQSESMAARLAASGHNELILVRESG-HLVQLEHPEIVNDGIDRLVRR
MLBr_02269|M.leprae_Br4923 TPPSLGR----EVADVLPNGRYLQIPDAGHLGFFERPEAVNAAALQFFAG
* . .:* * : . * :* ** :
Mb3196c|M.bovis_AF2122/97 VTRHVRDRRISS----------------------------
Rv3171c|M.tuberculosis_H37Rv VTRHVRDRRISS----------------------------
MMAR_1388|M.marinum_M VGGRSRAR-ISS----------------------------
MUL_2488|M.ulcerans_Agy99 VGGRSRAR-ISS----------------------------
MAV_4061|M.avium_104 ATRNLPTHRISS----------------------------
Mflv_4502|M.gilvum_PYR-GCK VSRSTRASAATGDQARASEATGDQARASAATGDQARASSR
Mvan_1865|M.vanbaalenii_PYR-1 VTGQGDATGATG----------------------------
TH_0684|M.thermoresistible__bu AADARRATS-------------------------------
MSMEG_2036|M.smegmatis_MC2_155 VISPQRLNS-------------------------------
MAB_3738c|M.abscessus_ATCC_199 STPPLFAAIKQRLRDRTGL---------------------
MLBr_02269|M.leprae_Br4923 VKGEWP----------------------------------