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TSSAQPTYREVVDDNGRVYRIGETDRDILGRSRAWMVWLPWISMMAISSSEYAFTSAEDTLADAHGWHGS HIFWLLGAWVLFQAAVAFPAGKLRESGKLSARAAMMLGAAGSLMGYLALAYSPNVFFAYLGFSFFGGGAA GFVYATCVNMVGKWYPERKGGKTGFVNGGFAYGSVPFIFIFTSYMDLANYQGVLFAVGVFLAGLVAVSGF FFKDPPKNWWPPHVDPLGAASDPRIARALRKNPPAVKQFTPMEAIKTGILPLMWFVLLCTAGINIFGIAM QVPFGKEMGFAGGIVALAMSLKAIINGTGRGVIGWISDRFGRRDTLILVCLVLGLAQYAVYFSGSIGNMP LFLLASMVSGFGGGAIFPLFAAMTADYFGENNNATNYGLVYSSKLVSGLVGAGMGSVVVSAWGYGAAFII AGSVGVACAFLTLLLKQPKLPKSERLAAEDPARHSSQAKEASLAAD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0167 | - | - | 100% (467) | transmembrane transport protein |
| M. smegmatis MC2 155 | MSMEG_0170 | - | e-151 | 57.89% (437) | transmembrane transport protein |
| M. smegmatis MC2 155 | MSMEG_0164 | - | 3e-86 | 38.75% (431) | transmembrane transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0805c | emrB | 1e-07 | 24.87% (197) | multidrug resistance integral membrane efflux protein EmrB |
| M. gilvum PYR-GCK | Mflv_2530 | - | 3e-09 | 24.49% (437) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv0783c | emrB | 1e-07 | 24.87% (197) | multidrug resistance integral membrane efflux protein EmrB |
| M. leprae Br4923 | MLBr_00556 | - | 2e-05 | 24.75% (101) | putative integral membrane drug transport protein |
| M. abscessus ATCC 19977 | MAB_0284c | - | 1e-09 | 25.42% (177) | major facilitator transporter |
| M. marinum M | MMAR_3825 | - | 1e-06 | 30.00% (130) | drug-transport integral membrane protein |
| M. avium 104 | MAV_3974 | - | 1e-09 | 31.58% (190) | permease of the major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_3988 | - | 1e-07 | 23.87% (222) | PUTATIVE putative MFS permease |
| M. ulcerans Agy99 | MUL_1806 | - | 1e-05 | 29.00% (100) | aminoglycosides/tetracycline-transport integral membrane |
| M. vanbaalenii PYR-1 | Mvan_3219 | - | 2e-06 | 21.48% (391) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0805c|M.bovis_AF2122/97 MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDRLDVGLLRTAGVCVL
Rv0783c|M.tuberculosis_H37Rv MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDRLDVGLLRTAGVCVL
MLBr_00556|M.leprae_Br4923 ------------------MSTRAGRRVAISAGSLAVLLGALDTYVVVTIM
MUL_1806|M.ulcerans_Agy99 ------------------MSTQTGRRVAISAGSLAVLLGALDTYVVVTIM
MMAR_3825|M.marinum_M MIG---------------ASLVAGRARRIARGTRRARSLNPWPALWAMLV
MAB_0284c|M.abscessus_ATCC_199 -------------------------MTRVVLIVLCALQVTMQLYVWIPIH
TH_3988|M.thermoresistible__bu ------MSESKASQDASAPAADPVDATARRTPWIAILAAALGIFVMITIE
Mflv_2530|M.gilvum_PYR-GCK --------MAHAQGRAPPWVGCFSRTLRQIRPMGRCLRVRPWIVWATGVL
MAV_3974|M.avium_104 -------------------------------------MVALGYGVISPAL
Mvan_3219|M.vanbaalenii_PYR-1 -------------------MAESDRADRRSVLLTLCLTEITSWGVLYYAF
MSMEG_0167|M.smegmatis_MC2_155 -------MTSSAQPTYREVVDDNGRVYRIGETDRDILGRSRAWMVWLPWI
Mb0805c|M.bovis_AF2122/97 ASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTGYMLALATVIPTAGW
Rv0783c|M.tuberculosis_H37Rv ASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTGYMLALATVIPTAGW
MLBr_00556|M.leprae_Br4923 RDIMHDVGIPVNQMQR-------------ITWIVTMYLLGYIAAMPLLSR
MUL_1806|M.ulcerans_Agy99 RDIMGSVGIPVNQLQR-------------ITWIVTWYLLGYIAAMPLLGR
MMAR_3825|M.marinum_M GYFMIVLDSTVVMLANPSIMADQHTSYYLVIWVTSAYLLTYAAPLLVAGR
MAB_0284c|M.abscessus_ATCC_199 DIVSASYGGQD------------------MTPALSAALFGYAAGFLLFGP
TH_3988|M.thermoresistible__bu ELPIGVLTLIGDDLGLSSG---------VVGLTVTIPGVLAGAVAVLTPT
Mflv_2530|M.gilvum_PYR-GCK AYMVAVFDRTTLGVSGLAAAERFTAGPTLLSMFVVLQVVVYAAAQVPAGL
MAV_3974|M.avium_104 PTFARSFGVSIKA----------------VTFLVTVFSLSRLCFAPISGL
Mvan_3219|M.vanbaalenii_PYR-1 SVLSPAICADTGWSAP------------AVTAAFSAGLVISALLGIPVGR
MSMEG_0167|M.smegmatis_MC2_155 SMMAISSSEYAFTSAEDTLADAHGWHGSHIFWLLGAWVLFQAAVAFPAGK
: .
Mb0805c|M.bovis_AF2122/97 AAD--RFGTRRLFMGSVLAFTLGSLLCAVA---PNILLLIIFRVVQGFGG
Rv0783c|M.tuberculosis_H37Rv AAD--RFGTRRLFMGSVLAFTLGSLLCAVA---PNILLLIIFRVVQGFGG
MLBr_00556|M.leprae_Br4923 ASD--RFGRKLLLQVSLAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVAS
MUL_1806|M.ulcerans_Agy99 ASD--RFGRKLMLQVSLLGFAAGSVVTALAGHFGDFHMLLAGRALQGVAS
MMAR_3825|M.marinum_M LGD--RFGPKNIYVIGLAVFTAASLWCGLS---GSIGMLITARAVQGLGA
MAB_0284c|M.abscessus_ATCC_199 VTD--RFGRRRVLLAGVAVMAVLTFLVPFA---PTPVLSGLFRVIQGFAG
TH_3988|M.thermoresistible__bu LIG--RLDRRLALVSALLLVFVSAATSAIA---PNLPVLLASRLFAGMAI
Mflv_2530|M.gilvum_PYR-GCK LLD--RYGSRALIVSGAALMASGQLVLAFT---DSLPVAVAGRAVVGLGD
MAV_3974|M.avium_104 LTE--RLGERRIYIGGLLIVAVSTAACAFS---QAYWQLMLCRVFSGVGS
Mvan_3219|M.vanbaalenii_PYR-1 WLD--RHGPRWIMTGGSVLGSIALAGVAAA---PDVVSFTAAWVVAGVAM
MSMEG_0167|M.smegmatis_MC2_155 LRESGKLSARAAMMLGAAGSLMGYLALAYS---PNVFFAYLGFSFFGGGA
: . : . : . * .
Mb0805c|M.bovis_AF2122/97 -GMLTPVSFAILAREAGPKRLGRVMAVVGIPMLLGPVGGPILGGWLIGAY
Rv0783c|M.tuberculosis_H37Rv -GMLTPVSFAILAREAGPKRLGRVMAVVGIPMLLGPVGGPILGGWLIGAY
MLBr_00556|M.leprae_Br4923 -GALLPITLALGADLWAQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLF
MUL_1806|M.ulcerans_Agy99 -GALLPITLALGADLWAQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLF
MMAR_3825|M.marinum_M -SLLFPQTLSIITRIFEPQRRGVALAIWTATGGVATLVGPLAGGVLVQAL
MAB_0284c|M.abscessus_ATCC_199 -GAFSPSALSYLGEALPRRAATTAIGAVSTAYLMAGVLGQVMASVITQAW
TH_3988|M.thermoresistible__bu -GVFWALLAVVVARVAHPDDLPKALTLAFGGVSVAVVLGVPFAAWIGAMV
Mflv_2530|M.gilvum_PYR-GCK -AFTFISVLRLVPHWFAPRQIPVVTQLTGIVGQLGQVLSAVPFLALLSAQ
MAV_3974|M.avium_104 -TMFYVSALGLMIHISPADARGRIAGLFTTSFMVGAVGGPAVGGLAAGWG
Mvan_3219|M.vanbaalenii_PYR-1 SAVFYAPAFAALTRYFRPDAVRALTALTLAAGLASTVFAPLTAAISAHMD
MSMEG_0167|M.smegmatis_MC2_155 AGFVYATCVNMVGKWYPERK-GGKTGFVNGGFAYGSVPFIFIFTSYMDLA
. :
Mb0805c|M.bovis_AF2122/97 G-WRWIFLVNLPVGLSALVLAAIVFPR-DRPAASENFDYMGLLLLSPGLA
Rv0783c|M.tuberculosis_H37Rv G-WRWIFLVNLPVGLSALVLAAIVFPR-DRPAASENFDYMGLLLLSPGLA
MLBr_00556|M.leprae_Br4923 SDWRYVFWINIPLTAIAMLMIQVSLSAHDRGDELEKVDVVGGVLLAIALG
MUL_1806|M.ulcerans_Agy99 HDWRDVFWINVPLTAIAMLMIQFSLPAHDKNAEPEKIDLVGGALLAIALG
MMAR_3825|M.marinum_M G-WQWIFFINVPIGLAGLVLAALLLPV--LPVHRPQLDLLGAALSALGVF
MAB_0284c|M.abscessus_ATCC_199 G-WQWLFWLSAAGLAVNVALLALVMHEERAGDPS----------------
TH_3988|M.thermoresistible__bu G-WRWAFVLVGALGLMVAVALTVLLPP-----------------------
Mflv_2530|M.gilvum_PYR-GCK G-WSVAYASAAAGGVLLIVVVLLLVRDTPQGSAASP--------------
MAV_3974|M.avium_104 LTAPFVVYGVAMLGVALVLFLGLRNSALAAPPPP----------------
Mvan_3219|M.vanbaalenii_PYR-1 WRETYLVLAAAMAVITVPAHFFGLRRP-----------------------
MSMEG_0167|M.smegmatis_MC2_155 N-YQGVLFAVGVFLAGLVAVSGFFFKDPPKNWWPPHVDPLG---------
Mb0805c|M.bovis_AF2122/97 TFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRTEHP-LIDM
Rv0783c|M.tuberculosis_H37Rv TFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRTEHP-LIDM
MLBr_00556|M.leprae_Br4923 LVVIGLYNPQPDSKQVLPSYGVPVLVG-GIVATVAFAVWERCARTRLIDP
MUL_1806|M.ulcerans_Agy99 LAVIGLYNPNPDGKEVLPSYGLPVLTG-AIVAAVAFFAWERFARTRLIDP
MMAR_3825|M.marinum_M LVLFALQEGQHAG--WAPWTSMMLIGGVGVIAVFVYWQSVNRGDP-LVPL
MAB_0284c|M.abscessus_ATCC_199 ---------------------------------------TRVVSGFAAQA
TH_3988|M.thermoresistible__bu -------------------------------------VPVAERTTLGQLG
Mflv_2530|M.gilvum_PYR-GCK -------------------------------------ETMSVRQTLASVK
MAV_3974|M.avium_104 ------------------------------------------TRSTVTMR
Mvan_3219|M.vanbaalenii_PYR-1 ------------------------------------WPHIEHHHLVEPPT
MSMEG_0167|M.smegmatis_MC2_155 ----------------------------AASDPRIARALRKNPPAVKQFT
Mb0805c|M.bovis_AF2122/97 RLFQNRAVAQANMTMTVLSLGLFGSFLLLPS-YLQQVLHQSPMQSGVHII
Rv0783c|M.tuberculosis_H37Rv RLFQNRAVAQANMTMTVLSLGLFGSFLLLPS-YLQQVLHQSPMQSGVHII
MLBr_00556|M.leprae_Br4923 AGVHIRPFLSALGASVAAGAALMVTLVNVEL-FGQGVLGMDQTQAAGLLV
MUL_1806|M.ulcerans_Agy99 NGVHFRPFLAALGSSVAAGAALMVTLVNVEL-FGQGVLSMDQTQAARMLL
MMAR_3825|M.marinum_M KIFSDRNFSLSSIGVAAVAFATTAMMVPAMF-FVQSAVGLSPIRSAALIA
MAB_0284c|M.abscessus_ATCC_199 RLLARADIAVPLVAVFVLMLSFVAMYTSLAT-ELVDALHLPESMG-TTIR
TH_3988|M.thermoresistible__bu AAWSIPAARTGVLVTLVMVTAHFTAYTYASP-VLQDRIHITESGVGPMLF
Mflv_2530|M.gilvum_PYR-GCK TVWLRPGTRLGFFTHMGTQFSITVFALMWGLPYLTVAQGLSPGVAGALLS
MAV_3974|M.avium_104 EALRVRAYQSALLSNFATGWSAFGLRMALVPLFVSDVMGRGIGTIGVVLA
Mvan_3219|M.vanbaalenii_PYR-1 RIARSRQFVALTVAFAMAGLASYAVIVNLVP--LMTAHGISTQAAALALG
MSMEG_0167|M.smegmatis_MC2_155 PMEAIKTGILPLMWFVLLCTAGINIFGIAMQVPFGKEMGFAGGIVALAMS
. :
Mb0805c|M.bovis_AF2122/97 PQGLGAMLAMPIAGAMMDRR---GPAKIVLVGIMLIAAGLGTFAFGVARQ
Rv0783c|M.tuberculosis_H37Rv PQGLGAMLAMPIAGAMMDRR---GPAKIVLVGIMLIAAGLGTFAFGVARQ
MLBr_00556|M.leprae_Br4923 WFLIALPIGAVLGGWGATKA---GDRTMTFVGLLITAGGYWLISHWPVDL
MUL_1806|M.ulcerans_Agy99 WFLIALPIGAVTGGWIATRV---GDRAVTFVGLLIAAGGYLLISHWPVDL
MMAR_3825|M.marinum_M PMVVMSGVVSPLVGKIVDRY---HPKLVVSSAFTMLAVALTWLSIEMSLS
MAB_0284c|M.abscessus_ATCC_199 LAGVPGMLVAPFVGSWVGRV---GTETGALVGYLLAAAGLAVEALGAG--
TH_3988|M.thermoresistible__bu VFGIAGFLGNFAAGPLLRRS---MRATYVVLPIGVMVG------------
Mflv_2530|M.gilvum_PYR-GCK LSVVTGIGSGVLIGVVTGRYP--HRRSWIVLGIIASNALMWTIVLALSG-
MAV_3974|M.avium_104 AFAGGNALAVVPSGYLSDRM---GRRTLLIVGLVTSGAATVWLGFVASLP
Mvan_3219|M.vanbaalenii_PYR-1 LGGAGQVLGRLGYQRMVRHLSVVPRTALIMAGVAVTTALLGLLTSVAT--
MSMEG_0167|M.smegmatis_MC2_155 LKAIINGTGRGVIGWISDRFG--RRDTLILVCLVLGLAQYAVYFSGSIGN
:
Mb0805c|M.bovis_AF2122/97 ADY---------LPILPTGLAIMGMGMGCSMMPLSGAAVQTLA-PHQIAR
Rv0783c|M.tuberculosis_H37Rv ADY---------LPILPTGLAIMGMGMGCSMMPLSGAAVQTLA-PHQIAR
MLBr_00556|M.leprae_Br4923 LNYRRSIFGLFSVPTMYADLLVAGLGLGLVIGPLSSATLRVVP-TAQHGI
MUL_1806|M.ulcerans_Agy99 PDYRHSIFGLFTVPAMHADLLVAGLGLGLVIGPLSSATLRVLP-AAQHGI
MMAR_3825|M.marinum_M TPIWR----------LVLPITALGVAIPFVWAPLAAIGSRDLP-AQLAGT
MAB_0284c|M.abscessus_ATCC_199 ----------------SVPIIIAGSNIFVAGIAVSSTAMVTMF-GDRAAP
TH_3988|M.thermoresistible__bu ---------------------VXXXGPNSRWRPDGTRM------------
Mflv_2530|M.gilvum_PYR-GCK --------------PAPLWVLVVLVAVISVGGPGSMVGFDFAR-TFNTGA
MAV_3974|M.avium_104 --------------VFLVAAGVVGVVTGIYMSPLQAAVADILGNEARAGL
Mvan_3219|M.vanbaalenii_PYR-1 ----------------LITVAVVAGVVRGVMTLLQATAVTERWGITHYGQ
MSMEG_0167|M.smegmatis_MC2_155 ------------MPLFLLASMVSGFGGGAIFPLFAAMTADYFG-ENNNAT
Mb0805c|M.bovis_AF2122/97 GSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPESGAGR
Rv0783c|M.tuberculosis_H37Rv GSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPESGAGR
MLBr_00556|M.leprae_Br4923 ASAAVVVARMTGMLIGVAALTAWGLYRFNQ---ILAGLSTAVPP------
MUL_1806|M.ulcerans_Agy99 ASAAVVVARMTGMLIGVAALSAWGLYRFNQ---ILAGLSAAVPP------
MMAR_3825|M.marinum_M GAGVYTAARQVGAVLGASGMAAFMTARIAAEMPPSPGNSPALRG------
MAB_0284c|M.abscessus_ATCC_199 RRGAGTALYGFTVFLGASSAP-----------------------------
TH_3988|M.thermoresistible__bu --------------------------------------------------
Mflv_2530|M.gilvum_PYR-GCK TLGTAQGMVNMGGFLASLLLMQAMG-------------------------
MAV_3974|M.avium_104 PVATVQMMSDLGAIVGSMAVG-----------------------------
Mvan_3219|M.vanbaalenii_PYR-1 LSGILSAPVMLSTALG----------------------------------
MSMEG_0167|M.smegmatis_MC2_155 NYGLVYSSKLVSGLVGAGMGSVVVS-------------------------
Mb0805c|M.bovis_AF2122/97 GAAVDPSSLPRQTNFAAQLLHDLSHAYAVVFVIATALVVSTLIPAAFLPK
Rv0783c|M.tuberculosis_H37Rv GAAVDPSSLPRQTNFAAQLLHDLSHAYAVVFVIATALVVSTLIPAAFLPK
MLBr_00556|M.leprae_Br4923 ----DATLIERAAAVADQAKRAYTMMYSDIFMITAIVCVIGALLGLLISS
MUL_1806|M.ulcerans_Agy99 ----DATLLERAAAIGAQYQQAFALMYGEIFTITAFVCVFGAVLGLLVSG
MMAR_3825|M.marinum_M -------SDGTAVRLPGLLREPFSVAMSQSMLLPACVALCGVAAGLFMLG
MAB_0284c|M.abscessus_ATCC_199 -------YLAHALGFRPLLGILVAALIGGAALVASSRRASGPVKPVVDIS
TH_3988|M.thermoresistible__bu --------------------------------------------------
Mflv_2530|M.gilvum_PYR-GCK ------MVMDASGGLTFESFRTAWTLQYAVWTLAVLGVLITRRKARRQLA
MAV_3974|M.avium_104 -----WAAEQIGYGWGFFISGVVLLIAAVGWVMAPETRTATELEADLMAA
Mvan_3219|M.vanbaalenii_PYR-1 ------PFVGAGLATLLGGYGAMFVVLGAVALAAALLATATRVRPVDADG
MSMEG_0167|M.smegmatis_MC2_155 -------AWGYGAAFIIAGSVGVACAFLTLLLKQPKLPKSERLAAEDPAR
Mb0805c|M.bovis_AF2122/97 QQASHRRAPLLSA--------
Rv0783c|M.tuberculosis_H37Rv QQASHRRAPLLSA--------
MLBr_00556|M.leprae_Br4923 RKE-HASEPKVPE--------
MUL_1806|M.ulcerans_Agy99 RKE-HAEEPEISEEPAVAPRP
MMAR_3825|M.marinum_M FSGSTDTGHEAADQPG-----
MAB_0284c|M.abscessus_ATCC_199 TQSSPLP--------------
TH_3988|M.thermoresistible__bu ---------------------
Mflv_2530|M.gilvum_PYR-GCK EDDRFLLEDIQT---------
MAV_3974|M.avium_104 SRTSSRCEQQL----------
Mvan_3219|M.vanbaalenii_PYR-1 ---------------------
MSMEG_0167|M.smegmatis_MC2_155 HSSQAKEASLAAD--------