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AANDTAAPVVVRDLRGRTYRVGEDPQDLIGCSRAWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLT AALWVLALWVVFQAGAAAPTAVLSHRFALSPSRAVPIGAALCAAGPLTVAHTDNIALAILGYSVLSGTGA GIVYATCTATVAKWYPENRAARIGLVTGAVGCGAVPFIAAFALTLTSTTRTALFTAVAVIVLVVVAQVGS LLKDPPAGWWPAHVDPRQWAFDKTLNRSLRHNVTAIRQFSPAEAARTPAFVVMYLIMVIAAAAALLAIVY VPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSAVPV AFVVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSHLMNPFVVA GLLSLGAAAMTRLLHLPGFPIVALPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0164 | - | - | 100% (447) | transmembrane transport protein |
| M. smegmatis MC2 155 | MSMEG_0170 | - | 1e-94 | 41.03% (429) | transmembrane transport protein |
| M. smegmatis MC2 155 | MSMEG_0167 | - | 3e-86 | 38.75% (431) | transmembrane transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2530 | - | 2e-12 | 25.59% (340) | major facilitator transporter |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3302 | - | 1e-08 | 22.33% (421) | major facilitator transporter |
| M. marinum M | MMAR_3100 | ermB_1 | 2e-06 | 26.29% (175) | integral membrane drug efflux protein, ErmB_1 |
| M. avium 104 | MAV_3974 | - | 8e-10 | 24.52% (363) | permease of the major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_0390 | - | 2e-08 | 23.05% (282) | major facilitator superfamily protein permease |
| M. ulcerans Agy99 | MUL_0354 | - | 1e-05 | 25.34% (146) | integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_3219 | - | 2e-11 | 24.44% (405) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2530|M.gilvum_PYR-GCK ------------------------------------MAHAQGRAPPWVGC
TH_0390|M.thermoresistible__bu --------------------------------------MNPGR-------
MAV_3974|M.avium_104 --------------------------------------------------
MAB_3302|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3219|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0164|M.smegmatis_MC2_155 -----------------------------------MAANDTAAPVVVRDL
MMAR_3100|M.marinum_M ---------------------------------------MEPCGADARAT
MUL_0354|M.ulcerans_Agy99 MLTSGSMTTTATIAAGEAMRVSSSSSPDLPDAGDTTKFLRPRNAALRSKA
Mflv_2530|M.gilvum_PYR-GCK FSRTLRQIRPMGRCLRVRPWIVWATGVLAYMVAV----------------
TH_0390|M.thermoresistible__bu --RARTAAGDDDERLAVRPWIVWATGLLAYIVAV----------------
MAV_3974|M.avium_104 -------------------MVALGYGVISPALPT----------------
MAB_3302|M.abscessus_ATCC_1997 ----MVTMVHVDEVGTARRWAMLAIALGSTAGAN----------------
Mvan_3219|M.vanbaalenii_PYR-1 ---------MAESDRADRRSVLLTLCLTEITSWG----------------
MSMEG_0164|M.smegmatis_MC2_155 RGRTYRVGEDPQDLIGCSRAWMLAFSWIAMAGIG----------------
MMAR_3100|M.marinum_M ATQLSPTQDNYPDRLDWPTIRIAGVCLIAAIMAN----------------
MUL_0354|M.ulcerans_Agy99 RGGSRSAARMANTKTNRKPRSARALCARAVAAPLGGARPLGERAGGRHRP
Mflv_2530|M.gilvum_PYR-GCK ------------------FDRTTLGVSGLAAAER-FTAGPTLLSMFVVLQ
TH_0390|M.thermoresistible__bu ------------------LDRTTLGVSGLAAADR-FNAAPAALSTFVVLQ
MAV_3974|M.avium_104 ------------------FARS-------------FGVSIKAVTFLVTVF
MAB_3302|M.abscessus_ATCC_1997 ------------------VFINGVAFLIPALHAE-RGLDLANAGLLSAMP
Mvan_3219|M.vanbaalenii_PYR-1 ------------------VLYYAFSVLSPAICAD-TGWSAPAVTAAFSAG
MSMEG_0164|M.smegmatis_MC2_155 ------------------VLQYGYGVALTALHVT-EGRSLTAALWVLALW
MMAR_3100|M.marinum_M ------------------LDISIVTVAQRTFTVA-FHSTQATVAWTVAGY
MUL_0354|M.ulcerans_Agy99 AREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFAAAAVGAVLAAF
.
Mflv_2530|M.gilvum_PYR-GCK VVVYAAAQVPAGLLLDRYGSR--ALIVSGAALMASGQLVLAFTDSLPVAV
TH_0390|M.thermoresistible__bu VIVYALAQVPAGLLLDRFGSK--ALIVAGAAVMATGQLILAFTESLTLAI
MAV_3974|M.avium_104 SLSRLCFAPISGLLTERLGER--RIYIGGLLIVAVSTAACAFSQAYWQLM
MAB_3302|M.abscessus_ATCC_1997 SFGMVLTLIAWGALIDKFGER--IALVSGLALTAVAAFAAAESPSLTVTG
Mvan_3219|M.vanbaalenii_PYR-1 LVISALLGIPVGRWLDRHGPR--WIMTGGSVLGSIALAGVAAAPDVVSFT
MSMEG_0164|M.smegmatis_MC2_155 VVFQAGAAAPTAVLSHRFALSPSRAVPIGAALCAAGPLTVAHTDNIALAI
MMAR_3100|M.marinum_M MLGMATATPMTGWAADRLGAK--RLFMGAVATFTLGSMLCASAPNIGLLI
MUL_0354|M.ulcerans_Agy99 GVGWAVGQLVCGWLVDSLGPR--ATLAWTMTIAAGVLVGMAEARSVAALL
. . . . : * :
Mflv_2530|M.gilvum_PYR-GCK AGRAVVGLGD-AFTFISVLRLVPHWFAPRQIPVVTQLTGIVGQLGQVLSA
TH_0390|M.thermoresistible__bu LARAIVGLGD-AVTFISVLRLVPHWFRPRQVPLVTQLTGICGQLGQVLSA
MAV_3974|M.avium_104 LCRVFSGVGS-TMFYVSALGLMIHISPADARGRIAGLFTTSFMVGAVG--
MAB_3302|M.abscessus_ATCC_1997 AFLLLGGAAA-AACNSASGRVVVGWFPPHQRGTVMGIRQMAQPLGVAAGA
Mvan_3219|M.vanbaalenii_PYR-1 AAWVVAGVAMSAVFYAPAFAALTRYFRPDAVRALTALTLAAGLASTVFAP
MSMEG_0164|M.smegmatis_MC2_155 LGYSVLSGTGAGIVYATCTATVAKWYPENRAARIGLVTGAVG-CGAVPFI
MMAR_3100|M.marinum_M TFRVVQGIGG-GVLGPLVLAIVTHQAGPRRLGRLLAVGAIPMLTAPMLGP
MUL_0354|M.ulcerans_Agy99 VGAMITGVVYDAPRPVMGAAIAELIPEPSRRAKLDAWRFGWIVSIGRAIT
. . :
Mflv_2530|M.gilvum_PYR-GCK VPFLALLSAQGWSVAYASAAAGGVLLIVVVLLLVRDTPQ-----------
TH_0390|M.thermoresistible__bu VLFLALLTARGWTPAYLSVVALGVLTIALTLALVQNTPD-----------
MAV_3974|M.avium_104 GPAVGGLAAGWGLTAPFVVYGVAMLGVALVLFLGLRNSA-----------
MAB_3302|M.abscessus_ATCC_1997 LVIPRIAEGHGVATALLFPAIVCAVSSAVCLVGIIDPPR-----------
Mvan_3219|M.vanbaalenii_PYR-1 LTAAISAHMDWRETYLVLAAAMAVITVPAHFFGLRRPWP-----------
MSMEG_0164|M.smegmatis_MC2_155 AAFALTLTSTTRTALFTAVAVIVLVVVAQVGSLLKDPPAGWWPAHVDPRQ
MMAR_3100|M.marinum_M ILGGWLIDSYGWQWIFLINVPAGLLAFGLAAILVPEDPPKPSERFDFIGM
MUL_0354|M.ulcerans_Agy99 GGVGGLLAAWSGVPVLFWINAVACALLALVAARCIPATA-----------
Mflv_2530|M.gilvum_PYR-GCK ---GSAASPETMSVRQTLASVKTVWLRPGTRLGFFTHMGTQFSITVFA--
TH_0390|M.thermoresistible__bu ---GRAAPATMGTVREIAASLKTVWLRAGTRLGFFTHMGTQFSVTVFA--
MAV_3974|M.avium_104 ---LAAPPPPTRSTVTMREALRVRAYQS----ALLSNFATGWSAFGLR--
MAB_3302|M.abscessus_ATCC_1997 ---PPRSEAPEEHLANPYRGSRVLWLIHGVSVLLVVPQVVVWTFT-----
Mvan_3219|M.vanbaalenii_PYR-1 ---HIEHHHLVEPPTRIARSRQFVALTVAFAMAGLASYAVIVNLVP----
MSMEG_0164|M.smegmatis_MC2_155 WAFDKTLNRSLRHNVTAIRQFSPAEAARTPAFVVMYLIMVIAAAAALL--
MMAR_3100|M.marinum_M LLLLPGIAMLLLGVSAIPGSGTVTDHRVWVPAISGAVLITAFALHAWYRT
MUL_0354|M.ulcerans_Agy99 ---HRPPVAPAVHVRAAHNSYRRAFSDGRLVLLFASSLATLTAVRGLY--
.
Mflv_2530|M.gilvum_PYR-GCK --------------------------------LMWGLPYLTVAQGLSPGV
TH_0390|M.thermoresistible__bu --------------------------------LMWGVPYLTVGQGLSTQM
MAV_3974|M.avium_104 --------------------------------MALVPLFVSDVMGRGIGT
MAB_3302|M.abscessus_ATCC_1997 ------------------------------------LVWLVTDRGWSIGA
Mvan_3219|M.vanbaalenii_PYR-1 ---------------------------------------LMTAHGISTQA
MSMEG_0164|M.smegmatis_MC2_155 --------------------------------AIVYVPIMAISQGFSLAV
MMAR_3100|M.marinum_M DHPLIDLRLFTDRVVRLANLALLLYVAGAAGASLLLPSYFQQLLHQTPMR
MUL_0354|M.ulcerans_Agy99 ----------------------------------ATVPMLMADSGLGAGE
.
Mflv_2530|M.gilvum_PYR-GCK AGALLSLSVVTGIGSGVLIGVVTGRYPHRRSWIVLGIIASNALMWTIV--
TH_0390|M.thermoresistible__bu AGAMLTLSVAVAIVAGVLIGIFTGRHPHRRSRLVLAIIASNAAAWTAV--
MAV_3974|M.avium_104 IGVVLAAFAGGNALAVVPSGYLSDRMG-RRTLLIVGLVTS--GAATVW--
MAB_3302|M.abscessus_ATCC_1997 ASVMVTVAQLVGALGRVAAGMWSDRWGSRMRPIRAIAAAASATMALLA--
Mvan_3219|M.vanbaalenii_PYR-1 AALALGLGGAGQVLGRLGYQRMVRHLS---VVPRTALIMAGVAVTTAL--
MSMEG_0164|M.smegmatis_MC2_155 AALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVY--
MMAR_3100|M.marinum_M SGLMMVPIGFGAMLTMPLTGAFMDSRGPRKVVLIGLTLIAAGTGTFVFGV
MUL_0354|M.ulcerans_Agy99 FGWAQVANAAAGIGLTPVITPWLGRKVAARINPRLDILAIAGGWTALTMA
.
Mflv_2530|M.gilvum_PYR-GCK LALSGPAPLWVLVVLVAVISVGGPGSMVGFDFARTFNTGATLGTAQGMVN
TH_0390|M.thermoresistible__bu LALPDRAPLWLLITLIVVISVGGPGSMVGFDFARTFNPSATLGTAQGMVN
MAV_3974|M.avium_104 LGFVASLPVFLVAAGVVGVVTGIYMSPLQAAVADILGNEARAGLPVATVQ
MAB_3302|M.abscessus_ATCC_1997 VTNQLDWSVSVVVMLVASVITVSDNGLAYTSIAEIAG-PFWSGRALGAQN
Mvan_3219|M.vanbaalenii_PYR-1 LGLLTSVATLITVAVVAGVVRGVMTLLQATAVTERWG-ITHYGQLSGILS
MSMEG_0164|M.smegmatis_MC2_155 SASSAVPVAFVVFAGLSGLSGGAFYPLIASLVADYFG-EPNAVRNFSLVY
MMAR_3100|M.marinum_M ANEADYLPTLLAGLTIAGMGLGCTGLLLAASVMRVLA-PHQIARGSALIS
MUL_0354|M.ulcerans_Agy99 GAALAHTTFGFAIAVAASAAGEIAWFVIAVGTVHRIAPPASGGRYHGIWS
. .
Mflv_2530|M.gilvum_PYR-GCK MGGFLASLLLMQAMGMVMD-----------------------------AS
TH_0390|M.thermoresistible__bu MGGFLASLLVMQAMGQILD-----------------------------AA
MAV_3974|M.avium_104 MMSDLGAIVGSMAVGWAAE-----------------------------QI
MAB_3302|M.abscessus_ATCC_1997 TGQLLAAAVAPPIFGAIAA-----------------------------AA
Mvan_3219|M.vanbaalenii_PYR-1 APVMLSTALGPFVGAGLAT-----------------------------LL
MSMEG_0164|M.smegmatis_MC2_155 SAKLFGGLIGVGVPALLIS-----------------------------SH
MMAR_3100|M.marinum_M VNQQISGSIGAALMSMILTNQFCRSHTISTANNMAVLRENAERHVVPIAP
MUL_0354|M.ulcerans_Agy99 MTLAIASVVAPIVSSCSLTHG-----------------------------
:. : .
Mflv_2530|M.gilvum_PYR-GCK GGLTFESFRTAWTLQYAVWTLAVLGVLITRRKARRQLAED-DRFLLEDIQ
TH_0390|M.thermoresistible__bu GGYSFDSFRLAWTVQYVVWVVAAVGILITRKKARRQMALEQERMLLESFE
MAV_3974|M.avium_104 G------YGWGFFISGVVLLIAAVGWVMAP-ETRTATELEADLMAASRTS
MAB_3302|M.abscessus_ATCC_1997 G------FSAAFAVC-ALFPLAAVGLVPVKLERPAP--------------
Mvan_3219|M.vanbaalenii_PYR-1 GG-----YGAMFVVLGAVALAAALLATATRVRPVDADG------------
MSMEG_0164|M.smegmatis_MC2_155 LMN-------PFVVAGLLSLGAAAMTRLLHLPGFPIVALPR---------
MMAR_3100|M.marinum_M SAVPARAVGPDFLVELQHDLSHAYTLTFAVAAVLGALAYFPAAFLPAKPT
MUL_0354|M.ulcerans_Agy99 --------GHRLVALVTVTVGLAGAALCLPLNRSGDVGVRDSQYTAVAAA
.
Mflv_2530|M.gilvum_PYR-GCK T----------------
TH_0390|M.thermoresistible__bu PGPRRHTGPDRTNRPHG
MAV_3974|M.avium_104 SRCEQQL----------
MAB_3302|M.abscessus_ATCC_1997 -----------------
Mvan_3219|M.vanbaalenii_PYR-1 -----------------
MSMEG_0164|M.smegmatis_MC2_155 -----------------
MMAR_3100|M.marinum_M TIAPGEVDVPG------
MUL_0354|M.ulcerans_Agy99 A----------------