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AHAQGRAPPWVGCFSRTLRQIRPMGRCLRVRPWIVWATGVLAYMVAVFDRTTLGVSGLAAAERFTAGPTL LSMFVVLQVVVYAAAQVPAGLLLDRYGSRALIVSGAALMASGQLVLAFTDSLPVAVAGRAVVGLGDAFTF ISVLRLVPHWFAPRQIPVVTQLTGIVGQLGQVLSAVPFLALLSAQGWSVAYASAAAGGVLLIVVVLLLVR DTPQGSAASPETMSVRQTLASVKTVWLRPGTRLGFFTHMGTQFSITVFALMWGLPYLTVAQGLSPGVAGA LLSLSVVTGIGSGVLIGVVTGRYPHRRSWIVLGIIASNALMWTIVLALSGPAPLWVLVVLVAVISVGGPG SMVGFDFARTFNTGATLGTAQGMVNMGGFLASLLLMQAMGMVMDASGGLTFESFRTAWTLQYAVWTLAVL GVLITRRKARRQLAEDDRFLLEDIQT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2530 | - | - | 100% (447) | major facilitator transporter |
| M. gilvum PYR-GCK | Mflv_4231 | - | 2e-12 | 25.13% (374) | major facilitator transporter |
| M. gilvum PYR-GCK | Mflv_1730 | - | 2e-10 | 21.04% (461) | EmrB/QacA family drug resistance transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1766c | narK2 | 1e-09 | 23.51% (336) | nitrate/nitrite transporter NarK2 |
| M. tuberculosis H37Rv | Rv1737c | narK2 | 1e-09 | 23.51% (336) | nitrate/nitrite transporter NarK2 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3302 | - | 5e-12 | 24.63% (337) | major facilitator transporter |
| M. marinum M | MMAR_1879 | - | 2e-12 | 20.85% (422) | drug-transport integral membrane protein |
| M. avium 104 | MAV_3846 | - | 4e-09 | 25.35% (359) | sugar transporter family protein |
| M. smegmatis MC2 155 | MSMEG_4767 | - | 1e-174 | 72.42% (417) | major facilitator superfamily protein permease |
| M. thermoresistible (build 8) | TH_0390 | - | 1e-173 | 72.32% (419) | major facilitator superfamily protein permease |
| M. ulcerans Agy99 | MUL_1382 | - | 1e-10 | 25.40% (374) | MFS transporter |
| M. vanbaalenii PYR-1 | Mvan_4127 | - | 0.0 | 82.93% (416) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2530|M.gilvum_PYR-GCK ------------MAHAQGRAPPWVGCFSRTLRQIRPMGRCLRVRPWIVWA
Mvan_4127|M.vanbaalenii_PYR-1 ------------------------------------------MRPWIVWA
MSMEG_4767|M.smegmatis_MC2_155 -----------------------------------------MVRPWIVWT
TH_0390|M.thermoresistible__bu -----------------------MNPGRRARTAAGDDDERLAVRPWIVWA
Mb1766c|M.bovis_AF2122/97 -----------------------------------------MRGQAANLV
Rv1737c|M.tuberculosis_H37Rv -----------------------------------------MRGQAANLV
MAB_3302|M.abscessus_ATCC_1997 ------------------------------MVTMVHVDEVGTARRWAMLA
MAV_3846|M.avium_104 MAGRRPQAPMTGNGTRPTPKYPGGMQAWGMQTDPVATPDVGAGTRWSIMV
MUL_1382|M.ulcerans_Agy99 ------------------------------MIHDPTASRSLFASRVTVLL
MMAR_1879|M.marinum_M ----------------------------MPASPGIRCNAAPVQTHRDTLW
Mflv_2530|M.gilvum_PYR-GCK TGVLAYMVAVFDRTTLGVSGLAAAERFTAGPTLLSMFVVLQVVVYAAAQV
Mvan_4127|M.vanbaalenii_PYR-1 TGLLAYIVAVLDRTTLGVSGLAAADRFGAGPSLLSTFVVLQVVVYAGAQV
MSMEG_4767|M.smegmatis_MC2_155 TGLLAYIIAVLDRTTLGVSGLQAADRFSATPTVLSTFVVLQVVVYAGAQV
TH_0390|M.thermoresistible__bu TGLLAYIVAVLDRTTLGVSGLAAADRFNAAPAALSTFVVLQVIVYALAQV
Mb1766c|M.bovis_AF2122/97 LATWISVVNFWAWNLIGPLSTSYARDMSLSSAEASLLVATPILVGALGRI
Rv1737c|M.tuberculosis_H37Rv LATWISVVNFWAWNLIGPLSTSYARDMSLSSAEASLLVATPILVGALGRI
MAB_3302|M.abscessus_ATCC_1997 IALGSTAGANVFINGVAFLIPALHAERGLDLANAGLLSAMPSFGMVLTLI
MAV_3846|M.avium_104 VSLLATASSFLFINGVAFLIPSLQGARGIRLDEAGLLASMPSWGMVVTLV
MUL_1382|M.ulcerans_Agy99 AIALSAFTMRSAVTSMAPLLARVADTMGFGGTVIGVFGMLPTAMFALAGF
MMAR_1879|M.marinum_M AIAIGIFMTSVDDTVVYVANPSIMAGLNTSYHMVIWVTSGYVLAYTVPSL
. : . . .
Mflv_2530|M.gilvum_PYR-GCK PAGLLLDRYGSRALIVSGAALMASGQLVLAFTDSLP-VAVAGRAVVGLGD
Mvan_4127|M.vanbaalenii_PYR-1 PAGLLLDRYGSRALIASGAALMASGQLGLAFTESLP-AAIAARAVVGLGD
MSMEG_4767|M.smegmatis_MC2_155 PAGVLLDRFGSRVLIVCGAALMAGGQLVLAFSESLP-AAIGARAIVGLGD
TH_0390|M.thermoresistible__bu PAGLLLDRFGSKALIVAGAAVMATGQLILAFTESLT-LAILARAIVGLGD
Mb1766c|M.bovis_AF2122/97 VTGPLTDRFGGRAMLIAVTLASILPVLAVGVAATMGSYALLVFFGLFLGV
Rv1737c|M.tuberculosis_H37Rv VTGPLTDRFGGRAMLIAVTLASILPVLAVGVAATMGSYALLVFFGLFLGV
MAB_3302|M.abscessus_ATCC_1997 AWGALIDKFGERIALVSGLALTAVAAFAAAESPSLT--VTGAFLLLGGAA
MAV_3846|M.avium_104 AWGYVLDRVGERVVMTTGSALTALAAYAASSAHSMV--LIAVYLFLGGMA
MUL_1382|M.ulcerans_Agy99 AA-PLSRRFGPERLALLSVLATAAGTAGRSMASDTS--ELMAFTTLALVG
MMAR_1879|M.marinum_M VAGRLGDRFGVKNLYLAGLAVFTVSSLWCGVSGTIE--ILIAARVAQGIG
: : * . . :
Mflv_2530|M.gilvum_PYR-GCK AFTFISV-LRLVPHWFAPRQIPVVTQLTGIVGQLGQVLSAVPFLALLSAQ
Mvan_4127|M.vanbaalenii_PYR-1 AVTFISV-LRLVPHWFAPRQIPVVTQLTGICGQLGQVLSAIPFLALLSAS
MSMEG_4767|M.smegmatis_MC2_155 AVTFISV-LRLVPHWFKPSQVPLLTQLTGICGQLGQVLSAVPFLALLTAA
TH_0390|M.thermoresistible__bu AVTFISV-LRLVPHWFRPRQVPLVTQLTGICGQLGQVLSAVLFLALLTAR
Mb1766c|M.bovis_AF2122/97 AGTIFAVGIPFANNWYQPARRGFSTGVFGMG-MVGTALSAFFTPRFVRWF
Rv1737c|M.tuberculosis_H37Rv AGTIFAVGIPFANNWYQPARRGFSTGVFGMG-MVGTALSAFFTPRFVRWF
MAB_3302|M.abscessus_ATCC_1997 AAACNSASGRVVVGWFPPHQRGTVMGIRQMAQPLGVAAGALVIPRIAEGH
MAV_3846|M.avium_104 AASCNTAGGRLVSAWFPPHQRGLAMGIRQTAQPLGIALGAMVIPELAE-H
MUL_1382|M.ulcerans_Agy99 MGIANIVVPPLVKKYFN-DRVALMSAIYLACLQLGTIMPAVAAVPLAESY
MMAR_1879|M.marinum_M AALLYTQTFTIVTRAFPPERRGAAATVWAAAAGFGNLVGPLLGGALVDTL
.. : : : .* .. :
Mflv_2530|M.gilvum_PYR-GCK GWSVAYASAAAGGVLLIV-VVLLLVRDTPQGSAASPE-------------
Mvan_4127|M.vanbaalenii_PYR-1 GWSVAYASAAALGVLSIV-LTLAIVRNTPDGSAATSE-------------
MSMEG_4767|M.smegmatis_MC2_155 GWTPAYLSVGAFGLLVMA-LVLAVVKNTPHGRVVATE-------------
TH_0390|M.thermoresistible__bu GWTPAYLSVVALGVLTIA-LTLALVQNTPDGRAAPAT-------------
Mb1766c|M.bovis_AF2122/97 GLFTTHAIVAAALASTAV-VAMVVLRDAPYFRPNADP-------------
Rv1737c|M.tuberculosis_H37Rv GLFTTHAIVAAALASTAV-VAMVVLRDAPYFRPNADP-------------
MAB_3302|M.abscessus_ATCC_1997 GVATALLFPAIVCAVSSA-VCLVGIIDPPRPPRSEAP-------------
MAV_3846|M.avium_104 GPQAGLRFTALACVFGAV-ASVIGIVDPPRKPRASAS-------------
MUL_1382|M.ulcerans_Agy99 GWRASLAIWALIPAVAVLPWILVLVRRRTNGTDHAAR-------------
MMAR_1879|M.marinum_M GWQWIFFVNIPVGIVGLVLAVRFVPALPTHARRFDLIGVGLSGLGLLLIV
* .
Mflv_2530|M.gilvum_PYR-GCK -TMSVRQTLASVKTVWLRPGTRLGFFTHMGTQFSI---------------
Mvan_4127|M.vanbaalenii_PYR-1 -TMSVRETLTSVKTVWLRPGTRLGFFTHMGTQFSI---------------
MSMEG_4767|M.smegmatis_MC2_155 -TTSVRDIPGSVKTVWLRPGNRLGFFTHMGTQFSV---------------
TH_0390|M.thermoresistible__bu -MGTVREIAASLKTVWLRAGTRLGFFTHMGTQFSV---------------
Mb1766c|M.bovis_AF2122/97 -VLPRLKAAARLPVTWEMS-------FLYAIVFGG---------------
Rv1737c|M.tuberculosis_H37Rv -VLPRLKAAARLPVTWEMS-------FLYAIVFGG---------------
MAB_3302|M.abscessus_ATCC_1997 -EEHLANPYRGSRVLWLIHG-------VSVLLVVP---------------
MAV_3846|M.avium_104 -DQELASPYRGSLTLWRIHA-------VAGLMMMP---------------
MUL_1382|M.ulcerans_Agy99 -TGKKIGPIWRSPISWGLT--------FMFSMTSL---------------
MMAR_1879|M.marinum_M FGLQQGHAAGWSPWIWAMIAVGVGFVTVFVYWQSVNTSEPLIPLRIFGDR
*
Mflv_2530|M.gilvum_PYR-GCK ---------------TVFALMWGLPYLTVAQGLSPGVAGALLSLSVVTGI
Mvan_4127|M.vanbaalenii_PYR-1 ---------------TVFALMWGLPYLTEAQGLSAGVAGALLSLSVVSAI
MSMEG_4767|M.smegmatis_MC2_155 ---------------TVFALMWGVPYLTVAQGLSTAAAGALLTVSVVTAI
TH_0390|M.thermoresistible__bu ---------------TVFALMWGVPYLTVGQGLSTQMAGAMLTLSVAVAI
Mb1766c|M.bovis_AF2122/97 ---------------FVAFSNYLPTYITTIYGFSTVDAGARTAGFALAAV
Rv1737c|M.tuberculosis_H37Rv ---------------FVAFSNYLPTYITTIYGFSTVDAGARTAGFALAAV
MAB_3302|M.abscessus_ATCC_1997 ---------------QVVVWTFTLVWLVTDRGWSIGAASVMVTVAQLVGA
MAV_3846|M.avium_104 ---------------QTVTVTFMLVWLIRNLHWSVAAAGALVTLSQLLGA
MUL_1382|M.ulcerans_Agy99 ---------------ITYAMFAWLPVIVTSAGGSEALGGAMVATFSGVGF
MMAR_1879|M.marinum_M NFALCSFGVAVIAFVAAAMMLPGVFYMQTVRGLSPTRTALLMAPLPIVVG
. : * . :
Mflv_2530|M.gilvum_PYR-GCK GSGVLIGVVTGRYPHRRSWIVLGIIASNALMWTIVLALSGPAPLWVLVVL
Mvan_4127|M.vanbaalenii_PYR-1 GCGVLIGILTGRYPHRRSRMVLAIITSNAVVWTVVLALPGPAPLWLLIVL
MSMEG_4767|M.smegmatis_MC2_155 SAGVAIGIFTGRHPHRRSRLVLWIIASNASIWTIVLALPGPAPTWLLVVL
TH_0390|M.thermoresistible__bu VAGVLIGIFTGRHPHRRSRLVLAIIASNAAAWTAVLALPDRAPLWLLITL
Mb1766c|M.bovis_AF2122/97 LARPVGGWLSDRIAPR--HVVLASLAG-TALLAFAAALQPPPEVWSAATF
Rv1737c|M.tuberculosis_H37Rv LARPVGGWLSDRIAPR--HVVLASLAG-TALLAFAAALQPPPEVWSAATF
MAB_3302|M.abscessus_ATCC_1997 LGRVAAGMWSDRWGSR-MRPIRAIAAAASATMALLAVTNQLDWSVSVVVM
MAV_3846|M.avium_104 LGRVAVGRWSDRLGSR-MRPVRYIAAAAVLVLLLLAWADYLNSRWQAGLM
MUL_1382|M.ulcerans_Agy99 LATLVTPRLCARAANPFPIVAASALCFLVGFAGLLWAPLTAPIVWAIFLG
MMAR_1879|M.marinum_M LLTPFIGKILDRAHPR-AVAGFGFSVVAISLIWFSIEMAPATPVWRLAVP
*
Mflv_2530|M.gilvum_PYR-GCK VAVISVGGPGSMVGFDFART-FNTGATLGTAQGMVNMGGFLASLLLMQAM
Mvan_4127|M.vanbaalenii_PYR-1 IVVISVGGPGSMVGFDFART-FNPRATLGTAQGMVNMGGFIASLLLMQAM
MSMEG_4767|M.smegmatis_MC2_155 IVIISVGGPGSMVGFDFART-FNPSATLGTAQGMVNMGGFLASLIVMQAM
TH_0390|M.thermoresistible__bu IVVISVGGPGSMVGFDFART-FNPSATLGTAQGMVNMGGFLASLLVMQAM
Mb1766c|M.bovis_AF2122/97 ITLAVCLGVGTGGVFAWVAR-RAPAASVGSVTGIVAAAGGLGGYFPPLVM
Rv1737c|M.tuberculosis_H37Rv ITLAVCLGVGTGGVFAWVAR-RAPAASVGSVTGIVAAAGGLGGYFPPLVM
MAB_3302|M.abscessus_ATCC_1997 LVASVITVSDNGLAYTSIAE-IAGPFWSGRALGAQNTGQLLAAAVAPPIF
MAV_3846|M.avium_104 VAISVIAVLDNGLEATAITE-FAGPYWSGRALGIQNTTQRMMAAAGPPLF
MUL_1382|M.ulcerans_Agy99 LGPSTFPAAITLINLRSRTE-SGSAALSGFTQGMG----YLLASPGPLIF
MMAR_1879|M.marinum_M IAFLGVGMVFAWPVLTVTATRDLPAELVGASSGVYNAARALGATLGSAGM
: * * : . :
Mflv_2530|M.gilvum_PYR-GCK GMVMDASGGLTFESFRTAWTLQYAVWTLAVLGVLITRRKARRQLAE-DDR
Mvan_4127|M.vanbaalenii_PYR-1 GMVMQAMGGISFESFRSAWMVQYVVWALAVVGILITRRKARRLLRDGNDR
MSMEG_4767|M.smegmatis_MC2_155 GVVLSHAGSYSFESFRLAWTVQYAIWILATIGILITRHKTRRLMAAEQER
TH_0390|M.thermoresistible__bu GQILDAAGGYSFDSFRLAWTVQYVVWVVAAVGILITRKKARRQMALEQER
Mb1766c|M.bovis_AF2122/97 GATYDPVD----NDYTVGLLLLVATALVACT---YTALHAREPVSEEASR
Rv1737c|M.tuberculosis_H37Rv GATYDPVD----NDYTVGLLLLVATALVACT---YTALHAREPVSEEASR
MAB_3302|M.abscessus_ATCC_1997 GAIAAAAGFS--AAFAVCALFPLAAVGLVPVKLERPAP------------
MAV_3846|M.avium_104 GALISAAKYP--PAWLLCALFPLAAMPLVPTRLLPPGLETRARRQSVRRL
MUL_1382|M.ulcerans_Agy99 GILYNATGR---WELSFGFLLVPLIALLAGGYHACKPRYLEDTLTPSRKS
MMAR_1879|M.marinum_M AALMTSRIAAQAPAIHDDAHTSAAAATEGVALQLPEFAREPFSASMSQSL
.
Mflv_2530|M.gilvum_PYR-GCK FLLEDIQT-----------------------
Mvan_4127|M.vanbaalenii_PYR-1 ILLEGVNP-----------------------
MSMEG_4767|M.smegmatis_MC2_155 MLLEGFEAHPPR-------------------
TH_0390|M.thermoresistible__bu MLLESFEPGPRRHTGPDRTNRPHG-------
Mb1766c|M.bovis_AF2122/97 -------------------------------
Rv1737c|M.tuberculosis_H37Rv -------------------------------
MAB_3302|M.abscessus_ATCC_1997 -------------------------------
MAV_3846|M.avium_104 RWWRAVRSHALPDIVRRPGQPG---------
MUL_1382|M.ulcerans_Agy99 GSDAVEDVVEGERLQECSTSCA---------
MMAR_1879|M.marinum_M LLPALIALLGVGAALFMSDLRAPRSTLAQGL