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NFLVDPPELTSARIYSGPGSGQMFSAAEAWDGLAAELRLAASSFESVTANLVAGAWQGASATAMAAVATP HVRLLQGLAGQAEQAAAQARVVASAFEAVRAATVHPALVAANRAQFVSLALSNIFGQNAPAIAAVETDYE EMWAQDVTAMVGYHSTSSAAAEQLTPFHRMLAGLSGRSVSSAVAGGRLGGFVIPGLSIGNRGLLNLGLGN TGNLNLGWGNAGNLNLGSGNTGGINLGSGNTGSFNPGWGNAGKLNLGSGNIGNMNLGSGNTGILNVGSGN IGDFNLGSGNIGNLNLGSGNIGKGNFGIGNTGNFNLGGGNTGGHNFGSGNTGGHNFGNGNSGNHNVGGGN YGNSNFGSGNIGSGNFGFGNSGNNNIGFGNSGNNNIGFGLTGDGQIGIGGLNSGSGNIGFGNSGNNNIGF FNSGDNNVGFLNSGSENKGFINSGLGTGRGPNLSAGIGNSGDLNTGLFNSGGSSATTNTGWFNSGSHNTG IGNSGDTNTGFFNSGNLNTGLFNSGDVNTGLFNSGNNNFAAFNAGSTNTGSFNAGSSNTLAFNSGDSNTG YAGSGNYNTGGFNSGASNTGFFDSGDLNTGIGSPVDQNVANSGFMNTGTGNSGIRGTGDYNSGFANRGTY NSGADSAGHEAGMTSNSGVLNIGSNNAGFLNYGNYNSGFRNTVYPSGTPVGNTSGFVNVGAVNSGLFSTG TGDSGFGQLADYSSGVLNAKDYISGYFH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5331 | - | - | 100% (729) | PPE family protein |
| M. marinum M | MMAR_1297 | - | 0.0 | 52.46% (751) | PPE family protein |
| M. marinum M | MMAR_4320 | - | 0.0 | 49.01% (759) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1575c | PPE21 | 0.0 | 53.21% (733) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 9e-31 | 30.51% (495) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv1548c | PPE21 | 0.0 | 53.21% (733) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-28 | 43.59% (156) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-22 | 33.70% (184) | PPE family protein |
| M. avium 104 | MAV_4704 | - | 9e-49 | 50.75% (199) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 4e-30 | 26.21% (622) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3113 | - | 8e-24 | 35.83% (187) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0965 | - | 1e-167 | 43.46% (826) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 9e-29 | 26.62% (695) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1575c|M.bovis_AF2122/97 --------------------------------------------------
Rv1548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5331|M.marinum_M --------------------------------------------------
MUL_0965|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
Mb1575c|M.bovis_AF2122/97 --------------------------------------------------
Rv1548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5331|M.marinum_M --------------------------------------------------
MUL_0965|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
Mb1575c|M.bovis_AF2122/97 --------------------------------------------------
Rv1548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5331|M.marinum_M --------------------------------------------------
MUL_0965|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
Mb1575c|M.bovis_AF2122/97 --------------------------------------------------
Rv1548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5331|M.marinum_M --------------------------------------------------
MUL_0965|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
Mb1575c|M.bovis_AF2122/97 -----------------------------------MN---FSVLPPEINS
Rv1548c|M.tuberculosis_H37Rv -----------------------------------MN---FSVLPPEINS
MMAR_5331|M.marinum_M -----------------------------------MN---FLVDPPELTS
MUL_0965|M.ulcerans_Agy99 -----------------------------------MN---FIMLPPEINS
MAV_4704|M.avium_104 -----------------------------------MTNPHFAWLPPEVNS
MLBr_01182|M.leprae_Br4923 -------------------------------------MFDFAALSPETNS
MAB_4783|M.abscessus_ATCC_1997 -----------------------------------MTAPVWMAAPPEVHS
TH_3113|M.thermoresistible__bu -----------------------------------------MALPPEVHS
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
: .
Mb1575c|M.bovis_AF2122/97 ALMFAGAGPGPMLAAASAWTGLAGDLGSAAASFSAVTSQLATGSWQGPAS
Rv1548c|M.tuberculosis_H37Rv ALMFAGAGPGPMLAAASAWTGLAGDLGSAAASFSAVTSQLATGSWQGPAS
MMAR_5331|M.marinum_M ARIYSGPGSGQMFSAAEAWDGLAAELRLAASSFESVTANLVAGAWQGASA
MUL_0965|M.ulcerans_Agy99 ARIFAGAGVGPTLAAAAAWDALAADLASAAQSFAAITVGLVGEAWQGAAA
MAV_4704|M.avium_104 ALIYSGPGPGPLLAAAAAWDGLAEELASSAQSFSSVTSDLASGSWQGASS
MLBr_01182|M.leprae_Br4923 TRMYLGPGSSPILTAAAAWVVLAKELTAAAQGLQSAVEALLT-TFEGESA
MAB_4783|M.abscessus_ATCC_1997 ALLSSGPGPGSLFAAADAWRSLSTEYSSAANELTTTLGSVRAGVWDGASA
TH_3113|M.thermoresistible__bu TLLRTGPGPGALSAAADAWRMLSDEYRAAAVELAAVVSQTCATAWEGVGA
Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
* .. .: . * ..
Mb1575c|M.bovis_AF2122/97 AAMTGAAASYARWLTTAAAQAEQAAGQAQAAVSAFE--------AALAAT
Rv1548c|M.tuberculosis_H37Rv AAMTGVAASYARWLTTAAAQAEQAAGQAQAAVSAFE--------AALAAT
MMAR_5331|M.marinum_M TAMAAVATPHVRLLQGLAGQAEQAAAQARVVASAFE--------AVRAAT
MUL_0965|M.ulcerans_Agy99 TAMAAAARPYASWLGTAAARAAVTAAQANAAAAVFE--------AAQAAT
MAV_4704|M.avium_104 AAMMTVANQYVSWLSAAAAQAEEVSHQASAIATAFE--------VALAAT
MLBr_01182|M.leprae_Br4923 AALAERVTPYEKWLTQNAASAELTATQLTVAANAYE--------TAFTMT
MAB_4783|M.abscessus_ATCC_1997 EQYQTAHVPYLSWLHETSAVSAGVAAQTETAATAYS--------EALATM
TH_3113|M.thermoresistible__bu DAYAAAHGPYLFWLTDTAAAAAAAGAQLEAAAAAHA--------SALAAM
Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
* .. . .
Mb1575c|M.bovis_AF2122/97 VHPGAVSANRGRLRSLVASNLLGQNAPAIAAVEAVY------------EQ
Rv1548c|M.tuberculosis_H37Rv VHPGAVSANRGRLRSLVASNLLGQNAPAIAAVEAVY------------EQ
MMAR_5331|M.marinum_M VHPALVAANRAQFVSLALSNIFGQNAPAIAAVETDY------------EE
MUL_0965|M.ulcerans_Agy99 AHPELVAANRNQLVSLVVSNLFGQNAPAIASTEAAY------------DQ
MAV_4704|M.avium_104 VQPAVVAANRALVQALAATNWLGQNTPAIADIEAAY------------EQ
MLBr_01182|M.leprae_Br4923 VPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEY------------TE
MAB_4783|M.abscessus_ATCC_1997 PTLGELAANHATHGALVATNFFGINTIPIAVNEADY------------IR
TH_3113|M.thermoresistible__bu PTMAELTANRTTHAALVATNFFGVNTIPIAVNEADY------------AR
Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A
MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
. :. * .
Mb1575c|M.bovis_AF2122/97 MWAADVAAMLGYHGEASAVALSLTPFT-------------------PSPS
Rv1548c|M.tuberculosis_H37Rv MWAADVAAMLGYHGEASAVALSLTPFT-------------------PSPS
MMAR_5331|M.marinum_M MWAQDVTAMVGYHSTSSAAAEQLTPFHRMLAGLS-----------GRSVS
MUL_0965|M.ulcerans_Agy99 LWAQDVAAMAGYHSGASAVAAQLAPWQQALRTLQNRVAGATTALPPPGPA
MAV_4704|M.avium_104 MWASDVAAMFGYHADASAAVAKLPPWN-----------------------
MLBr_01182|M.leprae_Br4923 MWIQDAAAMTSYQASVLEAVGATKAFT-----------------------
MAB_4783|M.abscessus_ATCC_1997 MWIQAATVMSTYQAVSESSVSAAPPTS-----------------------
TH_3113|M.thermoresistible__bu MWIQAATTMATYEAVASAAVSATPRTV-----------------------
Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG------
Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG------
MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH
: .
Mb1575c|M.bovis_AF2122/97 AAATPG--GAVIIAGFPFLDLGNVTIGGFNLASGNLGLGNLGSFNPGSAN
Rv1548c|M.tuberculosis_H37Rv AAATPG--GAVIIAGFPFLDLGNVTIGGFNLASGNLGLGNLGSFNPGSAN
MMAR_5331|M.marinum_M SAVAGGRLGGFVIPGLSIGNRGLLNLGLGNTGNLNLGWGNAGNLNLGSGN
MUL_0965|M.ulcerans_Agy99 AAAALPGAAAVGFPVLHIGNIGFANLSVGNIGDYNLGSGNTGSFNLGSGN
MAV_4704|M.avium_104 ------------------------------EVLQNLGFSNASTAVTRPAG
MLBr_01182|M.leprae_Br4923 -----------------APPLGVNEVGLAQEVVEEVVEEVVEEVVEAEQA
MAB_4783|M.abscessus_ATCC_1997 -------------PAPPVLSPDSGAAAR--------TAAQDATKPPPIVP
TH_3113|M.thermoresistible__bu -------------APPPILGAGTGESATAAITGAHVTAELRAAESRTLLD
Mflv_5091|M.gilvum_PYR-GCK -AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGAGGLG
Mvan_1264|M.vanbaalenii_PYR-1 -VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGTAG
MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS
Mb1575c|M.bovis_AF2122/97 TGSVNLGNANIG--------------------DLNLGSGNIGSYNLGGGN
Rv1548c|M.tuberculosis_H37Rv TGSVNLGNANIG--------------------DLNLGSGNIGSYNLGGGN
MMAR_5331|M.marinum_M TGGINLGSGNTG--------------------SFNPGWGNAGKLNLGSGN
MUL_0965|M.ulcerans_Agy99 IGDASLGSGNAG--------------------DSNVGFGNFGSNNVGIGN
MAV_4704|M.avium_104 SGAVARG-------------------------------------------
MLBr_01182|M.leprae_Br4923 ISQAALDQAVN---------------------------------------
MAB_4783|M.abscessus_ATCC_1997 DPNDPIEMLLK------------------------------NSQHFLG--
TH_3113|M.thermoresistible__bu EINELIDRLFAP--------------------LFPPGFADALPDGLLGTL
Mflv_5091|M.gilvum_PYR-GCK ETGTTGGAGGVG--------------------GQGTAGGTGGVGGIGGAG
Mvan_1264|M.vanbaalenii_PYR-1 ETGVTGGVGGIG--------------------GQGTEGGTGGVGGVGGVG
MSMEG_0868|M.smegmatis_MC2_155 TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY
Mb1575c|M.bovis_AF2122/97 --------------------------------------------------
Rv1548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5331|M.marinum_M --------------------------------------------------
MUL_0965|M.ulcerans_Agy99 NGNNNIGIGLNGDDLIG---------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----------STGAVGG-------VGGKG----IQGGQG-----------
Mvan_1264|M.vanbaalenii_PYR-1 ----------ATGGAGG-------VGGKG----IQGGQG-----------
MSMEG_0868|M.smegmatis_MC2_155 SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA
Mb1575c|M.bovis_AF2122/97 TGDLNPGSGNTGTLNWGSGNIGSYN------------------LGGGNLG
Rv1548c|M.tuberculosis_H37Rv TGDLNPDSGNTGTLNWGSGNIGSYN------------------LGGGNLG
MMAR_5331|M.marinum_M IGNMNLGSGNTGILNVGSGNIGDFN------------------LGSGNIG
MUL_0965|M.ulcerans_Agy99 IGALNSGAGNLGFGNSGTNNIGFFN------------------SGDNNIG
MAV_4704|M.avium_104 -----YTSRIAGFLAPRAPQ------------------------------
MLBr_01182|M.leprae_Br4923 -------EGMEATVVPQVDQQVNVD------------------VATPQTA
MAB_4783|M.abscessus_ATCC_1997 --MYRALKGLITD--PVGTIVRIII------------------DFSTNPA
TH_3113|M.thermoresistible__bu --LAPLLPGATGDGPPMATIMSFLL------------------MGLSNPA
Mflv_5091|M.gilvum_PYR-GCK --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK
Mvan_1264|M.vanbaalenii_PYR-1 --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK
MSMEG_0868|M.smegmatis_MC2_155 KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV
Mb1575c|M.bovis_AF2122/97 SYNLGSG-------------------------NTGDTNFG----------
Rv1548c|M.tuberculosis_H37Rv SYNLGSG-------------------------NTGDTNFG----------
MMAR_5331|M.marinum_M NLNLGSG-------------------------NIGKGNFG----------
MUL_0965|M.ulcerans_Agy99 FFNSGSGNFGFENAGDINTGFWNGRDTNTGFGNSGLSNFG----------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 VPD-----------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 AAIVTWTP------------------------------------------
TH_3113|M.thermoresistible__bu YLFPVLVY------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGRGGLFG---------------KGGNAGNGAD-----------
Mvan_1264|M.vanbaalenii_PYR-1 GGNGGNGGRGSLFG---------------RGGNAGNGGN-----------
MSMEG_0868|M.smegmatis_MC2_155 GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP
Mb1575c|M.bovis_AF2122/97 --------------GGNTGNLNVGGGNTGNSNFGFG--------------
Rv1548c|M.tuberculosis_H37Rv --------------GGNTGNLNVGGGNTGNSNFGFG--------------
MMAR_5331|M.marinum_M --------------IGNTGNFNLGGGNTGGHNFGSG--------------
MUL_0965|M.ulcerans_Agy99 --------------FGNSGVNNVGAGNGGSSNVGLGNAGLLNTGSFNSGK
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 -----------------------SSSAAAPQLWG----------------
MAB_4783|M.abscessus_ATCC_1997 -------------------LFYVFAYAATFAVMG----------------
TH_3113|M.thermoresistible__bu -------------------LLFTGVVHTTVAVSGML--------------
Mflv_5091|M.gilvum_PYR-GCK -----------GGTGGAGGAGGTGG-TGGAGGTGG---------------
Mvan_1264|M.vanbaalenii_PYR-1 -----------GGTGGNGGNGGTGG-TGGNGGTGG---------------
MSMEG_0868|M.smegmatis_MC2_155 AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ
Mb1575c|M.bovis_AF2122/97 ----------------NTGNVNFGNGNTG----------DTNFGSG----
Rv1548c|M.tuberculosis_H37Rv ----------------NTGNVNFGNGNTG----------DTNFGSG----
MMAR_5331|M.marinum_M ----------------NTGGHNFGNGNSGNHNVGGGNYGNSNFGSG----
MUL_0965|M.ulcerans_Agy99 FNTGDFNSGSMNTGYFNSSGHNTGLGNSGFTNTGFFNSGDLNTGMGSPED
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
Mvan_1264|M.vanbaalenii_PYR-1 --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
MSMEG_0868|M.smegmatis_MC2_155 TDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRG
Mb1575c|M.bovis_AF2122/97 ---------NLGSGNIGFGNKGSH---------------------NIGFG
Rv1548c|M.tuberculosis_H37Rv ---------NLGSGNIGFGNKGSH---------------------NIGFG
MMAR_5331|M.marinum_M ---------NIGSGNFGFGNSGNN---------------------NIGFG
MUL_0965|M.ulcerans_Agy99 QSVANSGFRNAGSGNSGFNNTGSFSSGFFNSTNSNSEFLNAGGTVNSGIN
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGAGGTG----GDGGTGGTGGTGGTG-------------------
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGDGGTG----GTGGTGGTGGTGGTG-------------------
MSMEG_0868|M.smegmatis_MC2_155 GDGALGGNGGTGGVGLGNGGKGGNGGNGGNGG-----------TYVDPSH
Mb1575c|M.bovis_AF2122/97 NSGNNNIGFGLTGDNQIG-----------------------FGALNSGSG
Rv1548c|M.tuberculosis_H37Rv NSGNNNIGFGLTGDNQIG-----------------------FGALNSGSG
MMAR_5331|M.marinum_M NSGNNNIGFGLTGDGQIG-----------------------IGGLNSGSG
MUL_0965|M.ulcerans_Agy99 NSGNTNAGIGNLGDDNFGLFNNGTFNTGAGNSSGGAVFPYTSGLFNSGNG
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -GTGGTGGTGGAG-----------DGTGGTGGTGG----TGGQGGQGGQG
Mvan_1264|M.vanbaalenii_PYR-1 -GTGGTGGTGGAG-----------DGLGGTGGTGG----TGGFGGQGGQG
MSMEG_0868|M.smegmatis_MC2_155 TGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDG
Mb1575c|M.bovis_AF2122/97 --------------------------------------------NLGFGN
Rv1548c|M.tuberculosis_H37Rv --------------------------------------------NLGFGN
MMAR_5331|M.marinum_M --------------------------------------------NIGFGN
MUL_0965|M.ulcerans_Agy99 SSGVFNAGDEQSGFFGTSGLVLTGTDGLAATTTSGLPALDLPAPNLGIGN
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 ----------------------------------------------GFAQ
MAB_4783|M.abscessus_ATCC_1997 ---------------------------------------------TPIYA
TH_3113|M.thermoresistible__bu ------------------------------------------AQLVPLMP
Mflv_5091|M.gilvum_PYR-GCK G------------------------------------------------T
Mvan_1264|M.vanbaalenii_PYR-1 G------------------------------------------------T
MSMEG_0868|M.smegmatis_MC2_155 GEAL-------------------------------IRATVIGSNASGTAT
Mb1575c|M.bovis_AF2122/97 SGNGNIGFFNSGNNNIG------------------------MGNSGN-GV
Rv1548c|M.tuberculosis_H37Rv SGNGNIGFFNSGNNNIG------------------------MGNSGN-GV
MMAR_5331|M.marinum_M SGNNNIGFFNSGDNNVG------------------------FLNSGSENK
MUL_0965|M.ulcerans_Agy99 AGVGNLGLGNIGDYNLG------------------------SGNTGDANF
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 HLSPINDTLSMINNHAG------------------------MANAGLSLV
MAB_4783|M.abscessus_ATCC_1997 AIMGPAAGISIPLAITL------------------------ASLSQMPEA
TH_3113|M.thermoresistible__bu ALLPVAVAALGGLAGVW------------------------AGLSGLAGL
Mflv_5091|M.gilvum_PYR-GCK GGTGGQGG-LGGGGGTG-----------------------GQGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGQGG-LGGVGGTG-----------------------GTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155 GGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGG
Mb1575c|M.bovis_AF2122/97 GALSV---EFGSS--AERSSGFGNSGELSTGIGNSG----QLSTGWFNSA
Rv1548c|M.tuberculosis_H37Rv GALSV---EFGSS--AERSSGFGNSGELSTGIGNSG----QLSTGWFNSA
MMAR_5331|M.marinum_M GFINS---GLGTGRGPNLSAGIGNSGDLNTGLFNSGGSSATTNTGWFNSG
MUL_0965|M.ulcerans_Agy99 GSGNIGALNLGSGNHGDANLGFGNTGDNNIGLFNSG----DNNVGFFNSG
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 NGMGSAMKSLAPTTTKAAESAFKAMG----------------------SA
MAB_4783|M.abscessus_ATCC_1997 PPVDAPAETVPARIDQPHAVAMGGAPAPTASTAAPTP---------TTTS
TH_3113|M.thermoresistible__bu AGLTAVPAADGG--ASAAPVPAGGPSLPSGSSAPPAP---------TGSA
Mflv_5091|M.gilvum_PYR-GCK QGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGSGGTGGQGG
Mvan_1264|M.vanbaalenii_PYR-1 QGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGVGGTGGQGG
MSMEG_0868|M.smegmatis_MC2_155 HGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTAN
Mb1575c|M.bovis_AF2122/97 TTSTGWFNSGTTNTGWFNSGTTNTGIGNSG--------------GNLVTG
Rv1548c|M.tuberculosis_H37Rv TTSTGWFNSGTTNTGWFNSGTTNTGIGNSG--------------GNLVTG
MMAR_5331|M.marinum_M SHNTGIGNSGDTNTGFFNSGNLNTGLFNSGDVNT----------GLFNSG
MUL_0965|M.ulcerans_Agy99 GANFGLANSGDTNTGLWNAGSTNTGFGNAGSADFGFGNAGDRNMGFGNAG
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 VQSTGRGLLGSSSGGHVTAQLG---------------------------R
MAB_4783|M.abscessus_ATCC_1997 PATPGSAP--APTPPPAGAEGLGYAVRGDG---------------PGFGF
TH_3113|M.thermoresistible__bu APTTGTAPGGAGSPPPAGHSVPPAPHSAPP---------------VGTSG
Mflv_5091|M.gilvum_PYR-GCK LGGPGGSTGGAGGAGG--QAGTAGKGGLFG--------GSGSAGKAGATG
Mvan_1264|M.vanbaalenii_PYR-1 QGGPGGSTGGAGGAGG--QAGVAGKGGLFG--------GSGSAGTAGVTG
MSMEG_0868|M.smegmatis_MC2_155 AANPGSATGTATGGDGGKATGTASQGGNGGPSWV----QSGYGSTLGGNA
Mb1575c|M.bovis_AF2122/97 --SMGLFNSGHTNTGSFNAGSMNTGDFNSGNVNTGYFNSGNINTG-----
Rv1548c|M.tuberculosis_H37Rv --SMGLFNSGHTNTGSFNAGSMNTGDFNSGNVNTGYFNSGNINTG-----
MMAR_5331|M.marinum_M NNNFAAFNAGSTNTGSFNAGSSNTLAFNSGDSNTGYAGSGNYNTGGFNSG
MUL_0965|M.ulcerans_Agy99 AANMGAGNSGSYNTGSFNSGTLNTGDFNGGDHNTGWGNSGNTNTGG----
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 AASIGSLRVPQTWTTASQPVTAATRALSPARVAVATE-------------
MAB_4783|M.abscessus_ATCC_1997 GPTIGASTGATAHAPSSAVSAAAALACNPA-TGKSRR-------------
TH_3113|M.thermoresistible__bu PPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAA-------------
Mflv_5091|M.gilvum_PYR-GCK AAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGATGAAGA
Mvan_1264|M.vanbaalenii_PYR-1 ASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGSAGSAGS
MSMEG_0868|M.smegmatis_MC2_155 TGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATT
Mb1575c|M.bovis_AF2122/97 -----FFNSGDLNTGLFNSVNQPVQNSGWLHTGTNNSGYANAGTFNSGFD
Rv1548c|M.tuberculosis_H37Rv -----FFNSGDLNTGLFNSVNQPVQNSGWLHTGTNNSGYANAGTFNSGFD
MMAR_5331|M.marinum_M ASNTGFFDSGDLNTGIGSPVDQNVANSGFMNTGTGNSGIRGTGDYNSGFA
MUL_0965|M.ulcerans_Agy99 ------INSGDLNTGFGSSADQAVTNSGFGNNGSGNSGFNNTGDTNSGFH
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 ------------------SESAPLLGGGLPMAPMVPGGGSGTGGVNTALR
MAB_4783|M.abscessus_ATCC_1997 ------------------RRRRTIDDRGYRHEYATMDDHTPTGPQDPVTA
TH_3113|M.thermoresistible__bu ------------------AARESAPIRRRRGQKDGLHGHRHEHQQPASMS
Mflv_5091|M.gilvum_PYR-GCK AGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKAGATG
Mvan_1264|M.vanbaalenii_PYR-1 AGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKAGATG
MSMEG_0868|M.smegmatis_MC2_155 AGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYD
Mb1575c|M.bovis_AF2122/97 NN-------ARDEHAEFVTGNSGLANVGNYNAGIINVGDHLSGFRNSV--
Rv1548c|M.tuberculosis_H37Rv NN-------ARDEHAEFVTGNSGLANVGNYNAGIINVGDHLSGFRNSV--
MMAR_5331|M.marinum_M NRGTYNSGADSAGHEAGMTSNSGVLNIGSNNAGFLNYGNYNSGFRNTVY-
MUL_0965|M.ulcerans_Agy99 NAN----------TSALFSGHSGLLNAG---------GSQSVGINNTG--
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 LQP-----------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 VAS-----------------------------------------------
TH_3113|M.thermoresistible__bu AAT-----------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK TTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG-----------
Mvan_1264|M.vanbaalenii_PYR-1 TTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG-----------
MSMEG_0868|M.smegmatis_MC2_155 PAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQT
Mb1575c|M.bovis_AF2122/97 -PTITGTANISGFVNAGTS------------------ISGFFNFGSLMSG
Rv1548c|M.tuberculosis_H37Rv -PTITGTANISGFVNAGTS------------------ISGFFNFGSLMSG
MMAR_5331|M.marinum_M -PSGTPVGNTSGFVNVGAV------------------NSGLFSTGTGDSG
MUL_0965|M.ulcerans_Agy99 --SFNTVLFNTGFRTAGIA------------------NSATNGLLTATSG
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 ----------RAFVMPRNP------------------AAG----------
MAB_4783|M.abscessus_ATCC_1997 ----GTGAGRLGFAGVHTA------------------TTAVEATGLSTLD
TH_3113|M.thermoresistible__bu ----APSAAGIRVLGGAGR------------------ISRTRGS-VPHAE
Mflv_5091|M.gilvum_PYR-GCK AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGSGAGGAG--GAG
Mvan_1264|M.vanbaalenii_PYR-1 AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGSGTGGAG--GAG
MSMEG_0868|M.smegmatis_MC2_155 ADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNG
Mb1575c|M.bovis_AF2122/97 FANFDDEVSGYLNGDSRASGWIH
Rv1548c|M.tuberculosis_H37Rv FANFDDEVSGYLNGDSRASGWIH
MMAR_5331|M.marinum_M FGQLADYSSGVLNAKDYISGYFH
MUL_0965|M.ulcerans_Agy99 VANSGNNSSGGFNANPDQSGFFN
MAV_4704|M.avium_104 -----------------------
MLBr_01182|M.leprae_Br4923 -----------------------
MAB_4783|M.abscessus_ATCC_1997 GDAENRTIPMLPGTWDVTDDDR-
TH_3113|M.thermoresistible__bu ITPGDPTEPSSPTDRAHRPAEPN
Mflv_5091|M.gilvum_PYR-GCK GSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1 GSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGADGTPGTAGTTGANNP