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MDRYTVISADCHAGADLLDYREYLEAKYQDEFDDWAKTFVNPFGDLSEPDAEHNWDSDRRNAELDSDGVA GEVIFPNTVPPFFPQGSLAAPPPSTARDLELRWAGLRAHNRWLADFCSLSPERRAGVGQILLGDVDEAVA EVAQIAKLGLRGGVLLPGVAPGTGIPALYAEHWEPLWAACAQAGLVINHHGGNAGPSPIDGWGSSLAVWV YESHWWAHRALWHLIFSGVLDRYPDLTVVLTEQGTGWIPATLDSLDVAAARYRRPNSAIARFAGPTAGSL PLQPSQYWARQCYVGASFLRPVECAQRHRIGVDRIMWGSDYPHMEGTAPYSREALRHTFSDVDPDEVAAM VGGNAAAVYGFDLQALAPLAARIGPTVTEVAEPLAAIPADASSTAFEPDPIRAW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4820 | - | - | 100% (404) | hypothetical protein MMAR_4820 |
| M. marinum M | MMAR_4821 | - | 7e-74 | 39.85% (399) | hypothetical protein MMAR_4821 |
| M. marinum M | MMAR_2618 | - | 1e-29 | 29.08% (306) | amidohydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_4324 | - | 2e-25 | 28.12% (313) | amidohydrolase 2 |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0299 | - | 5e-07 | 24.03% (308) | putative amidohydrolase (aminocarboxymuconate-semialdehyde |
| M. avium 104 | MAV_3541 | - | 0.0 | 86.63% (404) | amidohydrolase |
| M. smegmatis MC2 155 | MSMEG_4837 | - | 2e-24 | 28.53% (319) | amidohydrolase 2 |
| M. thermoresistible (build 8) | TH_2277 | - | 8e-23 | 28.66% (307) | amidohydrolase family protein |
| M. ulcerans Agy99 | MUL_0389 | - | 0.0 | 98.51% (404) | hypothetical protein MUL_0389 |
| M. vanbaalenii PYR-1 | Mvan_0901 | - | 9e-31 | 31.91% (329) | amidohydrolase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4820|M.marinum_M --MDRYTVISADCHAGAD-----LLDYREYLEAKYQDEFD---DWAKTFV
MUL_0389|M.ulcerans_Agy99 --MDRYTVISADCHAGAD-----LFDYREYLEAKYQDEFD---DWAKTFV
MAV_3541|M.avium_104 --MDRYTVISADCHAGAD-----LLDYRDYLDPQYRDEFD---GWAKTYV
Mflv_4324|M.gilvum_PYR-GCK MNRDDMILISVDDHIVEP-----PDMFKNHLSKKYLVEAP---RLVHNED
MSMEG_4837|M.smegmatis_MC2_155 MNKDDMILISVDDHIIEP-----PDMFKNHLPAKYRDEAP---RLVHNPD
Mvan_0901|M.vanbaalenii_PYR-1 -MGSSTLIIDTDTHITEP-----PDLWTSRMSKSRWGNLIPEVKWVEEKQ
TH_2277|M.thermoresistible__bu -MSTPTLVYPAEGYGAPKNRRGRAPRDVTELGLPAGTEVFSADNHISVAE
MAB_0299|M.abscessus_ATCC_1997 ---MTSVRIDIHAHLWSD-------EYLSLLDGYGRPATD----------
. : :
MMAR_4820|M.marinum_M N----PFGDLSEPDAEHNWDSDR------RNAELDSDGVAGEVIFPNTVP
MUL_0389|M.ulcerans_Agy99 N----PFGDLSEPDAEHNWDSDR------RNAELDSDGVAGEVIFPNTVP
MAV_3541|M.avium_104 N----PFGDLSEPDAERNWNSAR------RNCELDTEGIAGEVIYPNTVP
Mflv_4324|M.gilvum_PYR-GCK GSDTWQFRDVVIPNVALNAVAGR------PKEEYGLEPQGLDEIRPGCWQ
MSMEG_4837|M.smegmatis_MC2_155 GSDTWQFRDTVIPNVALNAVAGR------PKEEYGLEPQGLDEIRKGCYD
Mvan_0901|M.vanbaalenii_PYR-1 GEYWCMDGQPVFTVGTCIMVPGEDGKP-VRSPRFPDYADRFSSMHPSAYD
TH_2277|M.thermoresistible__bu DIFYERFPDDLKGAAPRIWYEDGAYMVGMKGKSWVGGDFGRVLMQYDDLA
MAB_0299|M.abscessus_ATCC_1997 ------VHRGLGAGATRDDLDGR----------FELMDEAGVDLQILTAT
:
MMAR_4820|M.marinum_M P----------------FFPQGSLAAPPPSTAR---DLELRWAGLRAHNR
MUL_0389|M.ulcerans_Agy99 P----------------FFPQGSLAAPAPSTAR---DLELRWAGLRAHNR
MAV_3541|M.avium_104 P----------------FFPHASLAAPPPETAR---ELELRWAGLRAHNR
Mflv_4324|M.gilvum_PYR-GCK VDERVKDMNAGGILGSMCFPSFPGFAGRLFATE---DPEFSLALVQAYND
MSMEG_4837|M.smegmatis_MC2_155 PNERVKDMNAGGVLATMNFPSFPGFAARLFATD---DEEFSLALVQAYND
Mvan_0901|M.vanbaalenii_PYR-1 AKARLEVMDAYGIQAAAIFPNLGFVGPNIFAAAGPDALEFQTAALQAYND
TH_2277|M.thermoresistible__bu GAATNNIEARVQELAEDGITRELAFPNAVLALFHYPDKALRERVFRIYNE
MAB_0299|M.abscessus_ATCC_1997 P----------------ASPHFEDQAAAVASAR------------FINDE
. : :
MMAR_4820|M.marinum_M W-LADFCSLSPERRAGVGQILLGDVDEAVAEVAQ-IAKLGLRGGVLLPGV
MUL_0389|M.ulcerans_Agy99 W-LADFCSLSPERRAGVGQILLGDVDEAVAEVAQ-IAKLGLPGGVLLPGV
MAV_3541|M.avium_104 W-LADFCSLSPERRAGVGQILLGDLDEAVAEVAQ-IAKLGLRGGVLLPGI
Mflv_4324|M.gilvum_PYR-GCK WHVEEWCGAYPARFIPMTLPVIWDPEACAKEIRR-NAARGVHS-LTFSEN
MSMEG_4837|M.smegmatis_MC2_155 WHIDEWCASNPGRFIPMAIPAIWNPGLAAAEVRR-VAEKGVHS-LTFTEN
Mvan_0901|M.vanbaalenii_PYR-1 F-LLDWSSIAPDRLLSLALIPYWDVDAAVAEIER-CAAAGHKG-LVSTGK
TH_2277|M.thermoresistible__bu H-IADLQDRSNGHFYGVGLINWWDPKGTRSTLEQ-LKSLGLKTFLLPLNP
MAB_0299|M.abscessus_ATCC_1997 Y--AKLSSEYPGRFGALASLPLPHVPAALEELARAIDELGMYGASITTSV
. : : . : : *
MMAR_4820|M.marinum_M -APGTGIPALY-AEHWEPLWAACAQAGLVINHHGG--------NAGPSPI
MUL_0389|M.ulcerans_Agy99 -APGTGIPALY-AEHWEPLWAACAQAGLVINHHGG--------NAGPSPI
MAV_3541|M.avium_104 -APGTGIPPLY-AEHWEPLWAACAEAGVVVNHHGG--------NAGPSPT
Mflv_4324|M.gilvum_PYR-GCK -PSAMGYPSFHDFDHWKPMWDALVDTDTVLNVHIG--------SSGRLAI
MSMEG_4837|M.smegmatis_MC2_155 -PSTLGYPSFHDLEYWRPLWQALVDTETVMNVHIG--------SSGKLAI
Mvan_0901|M.vanbaalenii_PYR-1 -PHEHGYKLLA-DRYWDPMWAAAQDANLSISFHVGGGNLSRHLNDERTSV
TH_2277|M.thermoresistible__bu GKDDDGNIYDYGSRAMDPVWDEIEEAGLPVTHHIG---------ETPPKT
MAB_0299|M.abscessus_ATCC_1997 LGRSIADPIFD------PLYAELNRRRAVLFVHPAG---------CGAES
. *:: : * .
MMAR_4820|M.marinum_M DGWGSSLAVWVYESHWWAHRALWHLIFSGVLDRYPDLTVVLTEQGTGWIP
MUL_0389|M.ulcerans_Agy99 DGWGSSLAVLVYESHWWAHRALLHLIFSGVLDRYPDLTVVLTEQGTGWIP
MAV_3541|M.avium_104 DGWGSSFAVWVYETHWWAHRALWHLIFSGALDRHPDLTVVFTEQGAGWIP
Mflv_4324|M.gilvum_PYR-GCK TAPDAPMDVMITLQPMNIVQAAADLLWSRPIKEYPDLKIALSEGGTGWIP
MSMEG_4837|M.smegmatis_MC2_155 TAPDAPMDVMITLQPMNIVQAAADLLWSAPIKEFPTLKIALSEGGTGWIP
Mvan_0901|M.vanbaalenii_PYR-1 EGWRATLARLTTSFFLESGITLADLLMSGVLARYPKLRFVSVESAVGWIP
TH_2277|M.thermoresistible__bu PCEHNSVVVGMMVNVDSFREQFSKYVFSGILDRHPGLRIGWFEGGIAWVP
MAB_0299|M.abscessus_ATCC_1997 SLITDHSLTWSIGAPIEDTVAIMHLIVAGVPSRYPDMKIVTCHLG-GALP
. : : ..* : . . . . :*
MMAR_4820|M.marinum_M ATLDSLDVAAARYRRPNSAIARFAGPTAGSLPLQPSQYWARQCYVGASFL
MUL_0389|M.ulcerans_Agy99 ATLDSLDVAAARYRRPNSAIARFAGPTAGSLPLQPSQYWARQCYVGASFL
MAV_3541|M.avium_104 ATLASLDVAAARYARANSAIARFAGPTAGSLSLKPSQYWARQCYVGASFM
Mflv_4324|M.gilvum_PYR-GCK YFLERVDRTYEMHS------TWTGQDFKGKLPSEVFREHFLTCFIAD---
MSMEG_4837|M.smegmatis_MC2_155 YFLDRVDRTFEMHS------TWTHQNFGGKLPSEVFREHFMTCFISD---
Mvan_0901|M.vanbaalenii_PYR-1 FLLESLDFHYKKYEP------WLERPEFAGNDMLPSDYFHRQVYANY-WY
TH_2277|M.thermoresistible__bu TALQDAEHLLASYR-----------HMFNHELQHDIRHYWDNHMSASFMV
MAB_0299|M.abscessus_ATCC_1997 MVLERAHRQVTEWEA----------TQCPEAPRDAARRLWYDTVGHD--H
* .
MMAR_4820|M.marinum_M RPVECAQRHRIGVDRIMWGSDYPHMEGTAPYSREALRHTFS----DVDPD
MUL_0389|M.ulcerans_Agy99 RPVECAQRHRIGVDRIMWASDYPHMEGTAPYSREALRHTFS----DVDPD
MAV_3541|M.avium_104 RPVECAERHGIGVEKIMWGSDYPHYEGTAPYTREALRHTFS----DVPPD
Mflv_4324|M.gilvum_PYR-GCK -PVGVATRHQIGVDNICWEADYPHSDSMWPGAPEQLDEVLKA--NNVPDD
MSMEG_4837|M.smegmatis_MC2_155 -PVGVKNRHMIGIDNICWEMDYPHSDSMWPGAPEELSAVFDT--YDVPDD
Mvan_0901|M.vanbaalenii_PYR-1 EDLQPWHVAAIGEDNLMFETDYPHQTCLD---KEEIQHSINEGLSGVSET
TH_2277|M.thermoresistible__bu DPLGLELIDRIGVDNVFWSSDYPHNESTYGYSEKSLAAVVQ----AVGPE
MAB_0299|M.abscessus_ATCC_1997 TPALRAAVASLGVDRLIFGSDFPYQAGPRYVSSATYIEEGLS------AE
:* :.: : *:*:
MMAR_4820|M.marinum_M EVAAMVGGNAAAVYGFDLQALAPLAARIGPTVTEVAEPLAAIPADAS---
MUL_0389|M.ulcerans_Agy99 EVAAMVGGNAAAVYGFDLQALAPLAARIGPTVTEVAEPLAAIPADAS---
MAV_3541|M.avium_104 EVAAMVGGNAARVYGFDLDALAPLVDRIGPSVAEVAEPLAAVPADAS---
Mflv_4324|M.gilvum_PYR-GCK EINKMTYENAMRWYHWDPFTHIAKEQATVGALRKAAEGHDVSIQALSHHK
MSMEG_4837|M.smegmatis_MC2_155 EINKITHENAMRLYHFDPFAHVPKEQATVGALRKAAEGHDVSIRALS--K
Mvan_0901|M.vanbaalenii_PYR-1 TKEKILWRNAASLFNMDIAKLEKLT-------------------------
TH_2277|M.thermoresistible__bu NAVKIVSTNIQRFLGIAE--------------------------------
MAB_0299|M.abscessus_ATCC_1997 DASAILDHNGAELLGLTGV-------------------------------
: *
MMAR_4820|M.marinum_M -------STAFEPDPIRAW-----
MUL_0389|M.ulcerans_Agy99 -------STAFEPDPIRAW-----
MAV_3541|M.avium_104 -------STVFEPDPIRTW-----
Mflv_4324|M.gilvum_PYR-GCK EGERGGGAGHFDALNAAARGNSGA
MSMEG_4837|M.smegmatis_MC2_155 KDKTGASFADFQANAKAVSGARD-
Mvan_0901|M.vanbaalenii_PYR-1 ------------------------
TH_2277|M.thermoresistible__bu ------------------------
MAB_0299|M.abscessus_ATCC_1997 ------------------------