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MLGPLDKLLGKSRKTSHDALAVVTGAGSGIGAAFALELGRRGSAVVCSDIDEVAAQNTVAALTEAGARAI SIDCDVSRIEDVTALAERSQAWFDGPPTLVINNAGVGAGGAGIGEIPLDDWLWTLGINLWGPIHGCHVFT PILREAGRAVGPRGIINVASAAAFGAAPGMAAYNVSKAGVLSLSETLAAELSGTGINVTVLCPTFVKTNI VESGRISEQSSEVVTKLIRWTGFSPDKVARICLDANDRGDLYCMPQLDAKIGWNIKRMAPGTYTRAAGLI LRATMR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3700 | - | - | 100% (286) | short-chain membrane-associated dehydrogenase |
| M. marinum M | MMAR_3141 | - | 3e-86 | 57.14% (273) | short-chain membrane-associated dehydrogenase |
| M. marinum M | MMAR_1932 | ephD_1 | 2e-34 | 37.00% (273) | short-chain dehydrogenase EphD_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 3e-33 | 35.77% (246) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4610 | - | 1e-86 | 60.59% (269) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2214c | ephD | 3e-33 | 35.77% (246) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 5e-38 | 39.02% (246) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4478c | - | 7e-87 | 59.34% (273) | putative short-chain dehydrogenase/reductase |
| M. avium 104 | MAV_1797 | - | 1e-124 | 77.58% (281) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 1e-35 | 35.97% (278) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 1e-35 | 36.99% (246) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3643 | - | 1e-163 | 99.65% (286) | short-chain membrane-associated dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1521 | - | 1e-104 | 69.37% (271) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3700|M.marinum_M --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 MPATQQMS----RLVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWD
Rv2214c|M.tuberculosis_H37Rv MPATQQMS----RLVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWD
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
TH_4323|M.thermoresistible__bu MAT--------EHFIDSSGGVRIAAYEEGNPDGPTVVLVHGWPDSHVVWD
MSMEG_4280|M.smegmatis_MC2_155 MYT----------FVTSQDGTRIAVYQQGDPERPTLVMAHGWPDSHVLWD
MMAR_3700|M.marinum_M --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 GVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSP
Rv2214c|M.tuberculosis_H37Rv GVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSP
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
TH_4323|M.thermoresistible__bu SVAPLLADRFRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAVIDALAP
MSMEG_4280|M.smegmatis_MC2_155 GVVGELGDRYRIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDAVSP
MMAR_3700|M.marinum_M --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 GEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGG
Rv2214c|M.tuberculosis_H37Rv GEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGG
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
TH_4323|M.thermoresistible__bu GQRVHVLAHDWGSAGVWEYLARPEAEDRIASFTSVSGPSGDHLARYVLDG
MSMEG_4280|M.smegmatis_MC2_155 DAPVHVLAHDWGSVGIWEYLSRQGSAARMVSFTSVSGPSTDHYGAYVRRG
MMAR_3700|M.marinum_M --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 LRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVR-RNM
Rv2214c|M.tuberculosis_H37Rv LRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVR-RNM
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIR-RTM
TH_4323|M.thermoresistible__bu LAAPYRPRRFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSKALRRSLRL
MSMEG_4280|M.smegmatis_MC2_155 LARPYRPVQFARAVNLASRFSYWIPFSIPVLAPALMR---RGAARR---L
MMAR_3700|M.marinum_M --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 VGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPV
Rv2214c|M.tuberculosis_H37Rv VGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPV
MLBr_00862|M.leprae_Br4923 VDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPV
TH_4323|M.thermoresistible__bu RDGVPADRLHHSDTFAADAARSIKVYGANFLRTLRHARTDH---FVRVPV
MSMEG_4280|M.smegmatis_MC2_155 QAIDTPGPKFQSENLDIDAANSLKIYRANAIRSFTHVRRDH---YVQVPV
MMAR_3700|M.marinum_M --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 QLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
Rv2214c|M.tuberculosis_H37Rv QLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
MLBr_00862|M.leprae_Br4923 QLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
TH_4323|M.thermoresistible__bu QLIVNTRDPYVRPHVYDETDRWVSRLWRRDIKAGHWSPMSHPQVLATAVT
MSMEG_4280|M.smegmatis_MC2_155 QLICNRKDPVVRGEGYRDESKWVPLLWRRDLDAGHWAPFSHPRAIAQAVG
MMAR_3700|M.marinum_M ----------MLGPLDKL-LGKSRKTSHDALAVVTGAGSGIGAAFALELG
MUL_3643|M.ulcerans_Agy99 ----------MLGPLDKL-LGKSRKTSHDALAVVTGAGSGIGAAFALELG
MAV_1797|M.avium_104 -------------MLDRL-LHRS-KTSRGALAVVTGAGSGIGAAFALELG
Mvan_1521|M.vanbaalenii_PYR-1 -----------------M-GLFGAKRTHRADAVITGAGSGIGAAFAVELA
Mflv_4610|M.gilvum_PYR-GCK --------------MDILRWDRPPRLSRRANAVVTGAGSGIGRAFAVELA
MAB_4478c|M.abscessus_ATCC_199 -------------MVSLLGFGRGERRTRKVDAVVTGAASGIGRAFAVELA
Mb2237c|M.bovis_AF2122/97 DFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFA
Rv2214c|M.tuberculosis_H37Rv DFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFA
MLBr_00862|M.leprae_Br4923 DLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALA
TH_4323|M.thermoresistible__bu ELADHLAGAPAGRALLRAQVGRPREYFGDMLVAITGAGGGIGRETALAFA
MSMEG_4280|M.smegmatis_MC2_155 EFVDHMEGAPPARALRRAEVARPRKAFSDMLVSVTGAASGIGRATALEFA
. :***..*** *: :.
MMAR_3700|M.marinum_M RRGSAVVCSDIDEVAAQNTVAALTEAGARAISIDCDVSRIEDVTALAERS
MUL_3643|M.ulcerans_Agy99 RRGSAVVCSDIDEVAAQNTVAALTEAGARAISIGCDVSRIEDVTALAERS
MAV_1797|M.avium_104 KRGGTVVCSDIDQAAAQRTADAITEHGAKALATRCDVSQFGVVQALAEQS
Mvan_1521|M.vanbaalenii_PYR-1 RRGGRVVCSDVSVEAARGTADAIIADGGRALPAQCDVTDIDAMYRLAGEA
Mflv_4610|M.gilvum_PYR-GCK RRGGRVVCADIDPVRAKETVGLVVQAGGEGLDIACDVTDEEQVRELADSA
MAB_4478c|M.abscessus_ATCC_199 RRGGRVVCADVDLPGAKETAALIGER---AIEAACDVSVFDEVEALADTA
Mb2237c|M.bovis_AF2122/97 REGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERV
Rv2214c|M.tuberculosis_H37Rv REGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERV
MLBr_00862|M.leprae_Br4923 RRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQV
TH_4323|M.thermoresistible__bu REGAEVIVSDIDEATAKDTAAEIAARGGVAHAYQLDVSDAAAVDRFADEV
MSMEG_4280|M.smegmatis_MC2_155 RLGAEIVVSDIDEAGAKATATAIDEAGGVAHAYGLDVADPDAVQRFVDDV
: *. :: :*:. .: *. : . **: : :.
MMAR_3700|M.marinum_M QAWFDGPPTLVINNAGVGAGGAGIGEIPLDDWLWTLGINLWGPIHGCHVF
MUL_3643|M.ulcerans_Agy99 QAWFDGPPTLVINNAGVGAGGAGIGEIPLDDWLWTLGINLWGPIHGCHVF
MAV_1797|M.avium_104 QSWFGAPPTLVINNAGVGAGGAAIGDAPLDDWQWTLGINLWGPIHGCHVF
Mvan_1521|M.vanbaalenii_PYR-1 QTWFDGPPTLVINNAGVGAGGAFIGETELADWKWVLDINLWGPIHGCHVF
Mflv_4610|M.gilvum_PYR-GCK EKWFGAAASLVINNAGIGIGGNVIGATPKRDWEATLSVNLWGVIYGCEIF
MAB_4478c|M.abscessus_ATCC_199 EEWFGKPSDLVINNAGIGAGGQVVGAAPLADWQKTLGVNLWGVIHGSHVF
Mb2237c|M.bovis_AF2122/97 SAEHG-VPDIVVNNAGIGQAGRFL-DTPAEQFDRVLAVNLGGVVNGCRAF
Rv2214c|M.tuberculosis_H37Rv SAEHG-VPDIVVNNAGIGQAGRFL-DTPAEQFDRVLAVNLGGVVNGCRAF
MLBr_00862|M.leprae_Br4923 SAKHG-VPDIVVNNAGIGQAGRFL-DTPPEEFDRVLAVNLGGVVNCCRAF
TH_4323|M.thermoresistible__bu CARHG-VPDIVVNNAGIGHAGRFL-DTPRDQWDRVLEVNLGGVVNGCRAF
MSMEG_4280|M.smegmatis_MC2_155 CATHG-VPDIVVNNAGIGHAGNFL-DTPADQYERVLEVNFGGVVNCCRAF
.. . :*:****:* .* : :: .* :*: * : .. *
MMAR_3700|M.marinum_M TPILREAGRAVGPRGIINVASAAAFGAAPGMAAYNVSKAGVLSLSETLAA
MUL_3643|M.ulcerans_Agy99 TPILREAGRAVGPRGIINVASAAAFGAAPGMAAYNVSKAGVLSLSETLAA
MAV_1797|M.avium_104 TPILRDAAPSAAPRGIINVASAAAFGAAPGMAAYNVSKAGVLSLSETLAA
Mvan_1521|M.vanbaalenii_PYR-1 APILREAGR---PAGIINVASAAAFGAAPGMAAYNVSKAGTLSLSETLAA
Mflv_4610|M.gilvum_PYR-GCK VPRLRAKGS----GGIINVASAASFGAAPRMGAYNVSKAGVLSLSETLAA
MAB_4478c|M.abscessus_ATCC_199 APRLRALGR----GGIINVASAASFAAAPRMGAYNVSKAGVLALSETLAA
Mb2237c|M.bovis_AF2122/97 GQRLVERGTG---GHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRA
Rv2214c|M.tuberculosis_H37Rv GQRLVERGTG---GHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRA
MLBr_00862|M.leprae_Br4923 GQRLVERGTG---GHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRA
TH_4323|M.thermoresistible__bu APRLVERGTG---GHIVNIASMASYAPLQSLNAYCTSKAAVYMFSDCLRA
MSMEG_4280|M.smegmatis_MC2_155 GRRLVEQGTG---GHIVNVASMAAYSPAGSMNAYATSKAAVFMFSDCLRA
* . *:*::* *::.. : ** .***.. :*: * *
MMAR_3700|M.marinum_M ELSGTGINVTVLCPTFVKTNIVESGRISEQSSE---------VVTKLIRW
MUL_3643|M.ulcerans_Agy99 ELSGTGINVTVLCPTFVKTNIVESGRISEQSSE---------VVTKLIRW
MAV_1797|M.avium_104 ELSGTPVRVTVLCPTFVKTTILESGRISEESGE---------LAAKLMRW
Mvan_1521|M.vanbaalenii_PYR-1 ELAGTGINVTVLCPTFVKTNIVESGRISTGTSQ---------LAERLMRW
Mflv_4610|M.gilvum_PYR-GCK ELSGTGVAVTVLCPTFVKTNIVDNPGIEESAAK---------LATNLMKW
MAB_4478c|M.abscessus_ATCC_199 ELSGTGVAVTVLCPTFVKTSIVDSGIIEESAAR---------LAATAMKW
Mb2237c|M.bovis_AF2122/97 ELDAAGVGLTTICPGVIDTNIVATTGFHAPGTDEEKIDGRRGQIDKMFAL
Rv2214c|M.tuberculosis_H37Rv ELDAAGVGLTTICPGVIDTNIVATTGFHAPGTDEEKIDGRRGQIDKMFAL
MLBr_00862|M.leprae_Br4923 ELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRL
TH_4323|M.thermoresistible__bu ELDSAGIMLTTICPSTVNTNIIGSTRFNAPDGLDDVVDTRREQLQKLFAL
MSMEG_4280|M.smegmatis_MC2_155 ELAHAGIGVTTLCPGMIDTGIVDTTRFDVPAHKAGQVEARRAQVKKTFQA
** . : :*.:** :.* *: . : :
MMAR_3700|M.marinum_M TGFSPDKVARICLDANDRGDLYCMPQLDAKIGWNIKRMAPGTYTRAAGLI
MUL_3643|M.ulcerans_Agy99 TGFSPDKVARICLDANDRGDLYCMPQLDAKIGWNIKRMAPGTYTRAAGLI
MAV_1797|M.avium_104 TGFSADKVARICLDAHDRGDLYCMPQLDAQIGWHIKRLAPQAYTRAAGLV
Mvan_1521|M.vanbaalenii_PYR-1 TGFPAARVARSALDTLDRGGLYCMPQPEARIGWGVKRFTPTVFTRAAGIA
Mflv_4610|M.gilvum_PYR-GCK TGVSAESVARKTLDANDRGQLHVLPQVDAKILWLFKRAVPATYTRALGLV
MAB_4478c|M.abscessus_ATCC_199 TGVSADSVARGCLDAHDRGQLYVLPQFDARFMWQAKRLAPDTYTKALGIA
Mb2237c|M.bovis_AF2122/97 RSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTARLR
Rv2214c|M.tuberculosis_H37Rv RSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTARLR
MLBr_00862|M.leprae_Br4923 RRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIR
TH_4323|M.thermoresistible__bu RRFGPDKAAKAIVSAVKQNKPIRPVMPEAYFVYGVSRVLPQALRSTARGR
MSMEG_4280|M.smegmatis_MC2_155 RRYGPEKVAKAVTSAVSRNQALRPVTPEAYVAYGVSRLFPAALRRAARSQ
. .* .: .: :* : .* * . :
MMAR_3700|M.marinum_M LRATMR---
MUL_3643|M.ulcerans_Agy99 LRATMR---
MAV_1797|M.avium_104 SRINLP---
Mvan_1521|M.vanbaalenii_PYR-1 TRITT----
Mflv_4610|M.gilvum_PYR-GCK ERIAR----
MAB_4478c|M.abscessus_ATCC_199 ERFSRQRGN
Mb2237c|M.bovis_AF2122/97 VI-------
Rv2214c|M.tuberculosis_H37Rv VI-------
MLBr_00862|M.leprae_Br4923 VI-------
TH_4323|M.thermoresistible__bu VL-------
MSMEG_4280|M.smegmatis_MC2_155 VL-------