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AQQAQVTEEQARALAEESRESGWNKPSFAKELFLGRFPLELINPFPRPSDAEEARTAAFLCRLQEFLGTI DGSVIERDAQIPDEYVNGLAELGCFGMKIPSEYGGLSMSQVAYNRALMLASTVHTSLGALLSAHQSIGVP EPLKLAGSPEQKKKFLPRCAAGAISAFLLTEPDVGSDPARLASTATPIDGGQAYELEGVKLWTTNGVVAE LLVVMARVPKSEGHRGGISAFVVEADSPGITVERRNKFMGLRGIENGVTRLHRVRVPKENLIGREGDGLR IALTTLNAGRLAIPAMVTGAAKWSLKIAREWSGERVQWGKPLGKHEAVAGKISFIAATTYALEAVVEISG QMADEGRNDIRIEAALAKLWSSEMACQVADELLQIRGGRGYETAESLAARGERAAPVEQSLRDVRINRIF EGSSEIMRLLIAREAVDAHLTAAGDLAKPNTDLRKKAAAAVGASGFYAKWLPQLVFGEGQRPKAYHEFGP LAAHLRFIERSTRKLARNTFYGMARWQAKLEQKQGFLGRIVDIGAELFAMSAVCVRAEAQRVADPIVGRQ AYELAEAFCGQATLRVEALFHGLWTNTDVGDVRLTNDVLEGRYAWLEDGIIDPSEGTGPWIAHWEPGPST QPNVARRFLPDSTSAEAKL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4660 | fadE10 | - | 100% (650) | acyl-CoA dehydrogenase FadE10 |
| M. marinum M | MMAR_4034 | fadE | 1e-40 | 31.08% (399) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3847 | fadE19 | 4e-39 | 32.32% (362) | acyl-CoA dehydrogenase FadE19 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0897 | fadE10 | 0.0 | 85.85% (650) | acyl-CoA dehydrogenase FADE10 |
| M. gilvum PYR-GCK | Mflv_4370 | - | 1e-43 | 33.51% (382) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0873 | fadE10 | 0.0 | 85.85% (650) | acyl-CoA dehydrogenase FADE10 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-41 | 30.00% (360) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1188c | - | 9e-39 | 32.07% (368) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1001 | - | 0.0 | 86.25% (640) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0714 | - | 4e-43 | 33.97% (368) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4603 | - | 6e-46 | 33.15% (359) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_0278 | fadE10 | 0.0 | 99.08% (650) | acyl-CoA dehydrogenase FadE10 |
| M. vanbaalenii PYR-1 | Mvan_1476 | - | 2e-43 | 32.59% (359) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4370|M.gilvum_PYR-GCK ------------------------------MASPPANAAEAGIPSAEVND
MSMEG_0714|M.smegmatis_MC2_155 ------------------------------MTATLEHAT--GLP-----D
TH_4603|M.thermoresistible__bu -----------------------------------------MAVDRLLPS
Mvan_1476|M.vanbaalenii_PYR-1 -----------------------------------------MAVDRLLPT
MLBr_00737|M.leprae_Br4923 ----------------------------------MVGWSGNPLFDLFKLP
MAB_1188c|M.abscessus_ATCC_199 ---------------------------------------------MFNLT
MMAR_4660|M.marinum_M MAQQAQVTEEQARALAEESRESGWNKPSFAKELFLGRFPLELINPFPRPS
MUL_0278|M.ulcerans_Agy99 MAQQAQVTEEQARALAEESRESGWNKPSFAKELFLGRFPLELINPFPRPS
MAV_1001|M.avium_104 MAQQTQVTEEQARALAEESRETGWDKPSFAKELFLGRFPLELIHPFPQPS
Mb0897|M.bovis_AF2122/97 MAQQTQVTEEQARALAEESRESGWDKPSFAKELFLGRFPLGLIHPFPKPS
Rv0873|M.tuberculosis_H37Rv MAQQTQVTEEQARALAEESRESGWDKPSFAKELFLGRFPLGLIHPFPKPS
Mflv_4370|M.gilvum_PYR-GCK EDFQAILAATREFVRTAVVPREQEILSTDQVPDDLREQTKS-MGLFGYAI
MSMEG_0714|M.smegmatis_MC2_155 AEYRALRDRIFDAIWSELDPLEERIENEERIPNEIVLPILERIGAFGLLV
TH_4603|M.thermoresistible__bu QEAAELIELTREIADKVLDPIVDRHEKDETYPEGVFEQLGA-AGLLSLPQ
Mvan_1476|M.vanbaalenii_PYR-1 DEARELVDLARQIADKALDPIVDQHEKDETYPDGVFATLGE-AGLLSLPY
MLBr_00737|M.leprae_Br4923 EEHNELRATIRALAEKEIAPHAADVDQRARFPEEALAALNA-SGFNAIHV
MAB_1188c|M.abscessus_ATCC_199 EEQREIWNTAREFADIHIAPHALDWDRDKYFPVEIFPKAAA-LGMGGIYV
MMAR_4660|M.marinum_M DAEEARTAAFLCRLQEFLGTIDGSVIERDAQIPDEYVNGLAELGCFGMKI
MUL_0278|M.ulcerans_Agy99 DAEEARTAAFLCRLQEFLGTIDGSVIERDAQIPDEYVKGLAELGCFGMKI
MAV_1001|M.avium_104 DADEARTRAFLDQLRKFLDTVDGSVIERDAEIPAEYVRGLADLGCFGMKI
Mb0897|M.bovis_AF2122/97 DAEEARTEAFLVKLREFLDTVDGSVIERAAQIPDEYVKGLAELGCFGLKI
Rv0873|M.tuberculosis_H37Rv DAEEARTEAFLVKLREFLDTVDGSVIERAAQIPDEYVKGLAELGCFGLKI
: . * .
Mflv_4370|M.gilvum_PYR-GCK PQEWGGLGLNLAQDVELAMELGYTSLALRSMFGTNNGIAGQVLVGYGTDE
MSMEG_0714|M.smegmatis_MC2_155 PREYGGSGLSIAQYLPIISEFAKVQGGLRVIVHVHNSFA-HALSEIGNDE
TH_4603|M.thermoresistible__bu PEEWGGGGQPYEVYLQVLEEIAARWASVAVAVSVH-SLSSHPLLVFGTEE
Mvan_1476|M.vanbaalenii_PYR-1 PEEWGGGGQPYEVYLQVLEELAARWAAVAVAVSVH-SLSCHPLMSFGTDE
MLBr_00737|M.leprae_Br4923 PEEYGGQGADSVAACIVIEEVARVDASASLIPAVN-KLGTMGLILRGSEE
MAB_1188c|M.abscessus_ATCC_199 NPDVGGSGLTRLDASLIFEAMATGCSAVSAFISIH-NMAAWMIDEFGDEE
MMAR_4660|M.marinum_M PSEYGGLSMSQVAYNRALMLASTVHTSLGALLSAHQSIGVPEPLKLAGSP
MUL_0278|M.ulcerans_Agy99 PSEYGGLSMSQVAYNRALMLASTVHTSLGALLSAHQSIGVPEPLKLAGSP
MAV_1001|M.avium_104 PSEFGGLNMSQVAYNRALMMISSVHPSLGALLSAHQSIGVPEPLKLAGTP
Mb0897|M.bovis_AF2122/97 PSEYGGLNMSQVAYNRVLMMVTTVHSSLGALLSAHQSIGVPEPLKLAGTA
Rv0873|M.tuberculosis_H37Rv PSEYGGLNMSQVAYNRVLMMVTTVHSSLGALLSAHQSIGVPEPLKLAGTA
: ** . . : :. .
Mflv_4370|M.gilvum_PYR-GCK QKKTWLERIASGEIVASFALTEPGAGSNPSGLRTKAVRDGDGPHSGWILN
MSMEG_0714|M.smegmatis_MC2_155 QKAAVLHGAATGANSVAFALTEPGHGTG-ADLGSSAVRMGD----EYEIT
TH_4603|M.thermoresistible__bu QKKRWLPGMLSGEQIGAYSLSEPQAGSDAAALRCAATPTDG----GYVIN
Mvan_1476|M.vanbaalenii_PYR-1 QRQRWLPEMLGGSTIGAYSLSEPQAGSDAAALTCKAVAADG----GYRIN
MLBr_00737|M.leprae_Br4923 LKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGD----DWILN
MAB_1188c|M.abscessus_ATCC_199 QRRRWLPSMCTMETIGAYCLTEPECGSDAAALRTSAIRQGD----EYVLN
MMAR_4660|M.marinum_M EQKKKFLPRCAAGAISAFLLTEPDVGSDPARLASTATPIDGG--QAYELE
MUL_0278|M.ulcerans_Agy99 EQKKKFLPRCAAGAISAFLLTEPDVGSDPARLASTATPIDDG--QAYELE
MAV_1001|M.avium_104 EQKRKFLPRCAAGAISAFLLTEPDVGSDPARLASTATPVDDG--KAYELN
Mb0897|M.bovis_AF2122/97 EQKRRFLPRCAAGAISAFLLTEPDVGSDPARMASTATPIDDG--QAYELE
Rv0873|M.tuberculosis_H37Rv EQKRRFLPRCAAGAISAFLLTEPDVGSDPARMASTATPIDDG--QAYELE
: : :: *:* *:. : : * .. : :
Mflv_4370|M.gilvum_PYR-GCK GQKRFITNAPNADLFVTFARSRPADDKGAGIAVFLVPADTPGVDIGAKDK
MSMEG_0714|M.smegmatis_MC2_155 GEKWLITNSDIATHFIVFAKTAPTE-----VSAFLVPRDTDGLSIEPLPE
TH_4603|M.thermoresistible__bu GSKSWITHGGKADFYTLFARTG--EGSRG-VSCFLVPADQPGLSFGKPEE
Mvan_1476|M.vanbaalenii_PYR-1 GAKAWITHGGIADFYNLFARTG--EGSQG-ISCFLVPRDTEGLTFGKPEE
MLBr_00737|M.leprae_Br4923 GFKCWITNGGKSTWYTVMAVTDPDKGANG-ISAFIVHKDDEGFSIGPKEK
MAB_1188c|M.abscessus_ATCC_199 GVKQFISGAGAADLYVVMARTG-GPGPRG-ISTIVVPKGTPGLSFGAPER
MMAR_4660|M.marinum_M GVKLWTTNGVVAELLVVMARVPKSEGHRGGISAFVVEADSPGITVERRNK
MUL_0278|M.ulcerans_Agy99 GIKLWTTNGVVAELLVVMARVPKSEGHRGGISAFVVEADSPGITVERRNK
MAV_1001|M.avium_104 GVKLWTTNGVVAELLVVMARVPKSEGHRGGISAFVVEADSPGITVERRNK
Mb0897|M.bovis_AF2122/97 GVKLWTTNGVVADLLVVMARVPRSEGHRGGISAFVVEADSPGITVERRNK
Rv0873|M.tuberculosis_H37Rv GVKLWTTNGVVADLLVVMARVPRSEGHRGGISAFVVEADSPGITVERRNK
* * : . : :* :: ::* . *. . .
Mflv_4370|M.gilvum_PYR-GCK KMGQEGAWTADVNFTDVEVPDTALVGGSEDLGYRAAMTSLARGRVHIAAL
MSMEG_0714|M.smegmatis_MC2_155 TMGCKGGEHGHIRLAGVRVPATALIG-AEGEGNQHLERALEISRVFIAAS
TH_4603|M.thermoresistible__bu KMGLHAVPTTSAFYDNARIDADRRIG-EEGQGLQIAFSALDSGRLGIAAV
Mvan_1476|M.vanbaalenii_PYR-1 KMGLHAVPTTAAHYENAFVEADRRIG-AEGQGLQIAFSALDSGRLGIAAV
MLBr_00737|M.leprae_Br4923 KLGIKGSPTTELYFDKCRIPGDRIIG-EPGTGFKTALATLDHTRPTIGAQ
MAB_1188c|M.abscessus_ATCC_199 KMGWHAQPTAQVVFEDVRVPVANRIG-EEGIGFTIAMRGLNGGRLNIASC
MMAR_4660|M.marinum_M FMGLRGIENGVTRLHRVRVPKENLIG-REGDGLRIALTTLNAGRLAIPAM
MUL_0278|M.ulcerans_Agy99 FMGLRGIENGVTRLHRVRVPKENLIG-REGDGLRIALTTLNAGRLAIPAM
MAV_1001|M.avium_104 FMGLRGIENGVTRLHRVRVPSENLVG-REGDGLKIALTTLNAGRLSIPAS
Mb0897|M.bovis_AF2122/97 FMGLRGIENGVTRLHRVRVPKDNLIG-REGDGLKIALTTLNAGRLSLPAI
Rv0873|M.tuberculosis_H37Rv FMGLRGIENGVTRLHRVRVPKDNLIG-REGDGLKIALTTLNAGRLSLPAI
:* .. : :* . * * * : :
Mflv_4370|M.gilvum_PYR-GCK AVGAAQRALDESVAYAATATQGGTPIGDFQLVQAMLADQQTGVMAGRALV
MSMEG_0714|M.smegmatis_MC2_155 SLGTSERALELSVARAKERVTFGKPIGSRQAIQRYLAEMATDIYALRGLL
TH_4603|M.thermoresistible__bu ATGLAQAALDEAVAYANERTAFGRKIIDHQGLGFLLADMAAAVATARATY
Mvan_1476|M.vanbaalenii_PYR-1 AVGLAQAALDAAVDYSQERTTFGRKIIDHQGLAFLLADMAAAVDAARATY
MLBr_00737|M.leprae_Br4923 AVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIV
MAB_1188c|M.abscessus_ATCC_199 SLGGARSALEKVIEYLRTRKAFGEELIKFQALQFRLADMATELEAARTMV
MMAR_4660|M.marinum_M VTGAAKWSLKIAREWSGERVQWGKPLGKHEAVAGKISFIAATTYALEAVV
MUL_0278|M.ulcerans_Agy99 VTGAAKWSLKIAREWSGERVQWGKPLGKDEAVAGKISFIAATTYALEAVV
MAV_1001|M.avium_104 ATGSAKWALKIAREWSGERVQWGKPLAEHEAVARKLSFIAATVYALDAVL
Mb0897|M.bovis_AF2122/97 ATGVAKQALKIAREWSVERVQWGKPVGQHEAVASKISFIAATNYALDAVV
Rv0873|M.tuberculosis_H37Rv ATGVAKQALKIAREWSVERVQWGKPVGQHEAVASKISFIAATNYALDAVV
* :. :*. * : : : :: :
Mflv_4370|M.gilvum_PYR-GCK RDAARLWVTGQD-RRIAPSAAKLFCTEMAGKVADLAVQIHGGSGYM----
MSMEG_0714|M.smegmatis_MC2_155 ADAAHKWDSGKR-IPAEASMCKLFGLEAVGRVTDRALLIHGGIGYT----
TH_4603|M.thermoresistible__bu LDAARRRDQGRP-YSQQASIAKLTATDAAMKVTTDAVQVFGGVGYT----
Mvan_1476|M.vanbaalenii_PYR-1 LDAARRRDAGLP-YSRHASVAKLTATDAAMKVTTDAVQVFGGAGYT----
MLBr_00737|M.leprae_Br4923 YAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYT----
MAB_1188c|M.abscessus_ATCC_199 WRAAAAVTEGDPRAAELCAMAKRIATDVGFTVANEALQLHGGYGYL----
MMAR_4660|M.marinum_M EISGQMADEGRNDIRIEAALAKLWSSEMACQVADELLQIRGGRGYETAES
MUL_0278|M.ulcerans_Agy99 EISGQMADEGRNDIRIEAALAKLWSSEMACQVADELLQIRGGRGYETAES
MAV_1001|M.avium_104 ELSAQMADEGRNDIRIEAALAKLWSSEMACVIADEVMQIRGGRGYETAES
Mb0897|M.bovis_AF2122/97 ELSSQMADEGRNDIRIEAALAKLWSSEMACLVGDELLQIRGGRGYETAES
Rv0873|M.tuberculosis_H37Rv ELSSQMADEGRNDIRIEAALAKLWSSEMACLVGDELLQIRGGRGYETAES
:. * : .* : : : : ** **
Mflv_4370|M.gilvum_PYR-GCK ------REVPVERIYRDVRLLRLYEGTSEIQKLIIGGGLVKG--------
MSMEG_0714|M.smegmatis_MC2_155 ------RAYPVERLYRDARLNWLEEGTPTIQYMVAANELLSGYVFSDAFD
TH_4603|M.thermoresistible__bu ------RDYRVERYMREAKIMQIFEGTNQIQRLVIARGLTR---------
Mvan_1476|M.vanbaalenii_PYR-1 ------RDYRVERYMREAKITQIFEGTNQIQRLVISRHLARD--------
MLBr_00737|M.leprae_Br4923 ------SDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR---------
MAB_1188c|M.abscessus_ATCC_199 ------AEYGIEKIVRDLRVHQILEGTNEIMRVIVSRKLIEQGLPA----
MMAR_4660|M.marinum_M LAARGERAAPVEQSLRDVRINRIFEGSSEIMRLLIAREAVDAHLTAAGDL
MUL_0278|M.ulcerans_Agy99 LAARGERAAPVEQSLRDVRINRIFEGSSEIMRLLIAREAVDAHLTAAGDL
MAV_1001|M.avium_104 LAARGERAVPVEQVLRDLRINRIFEGASEIMRLLIAREAVDAHLAAAGDL
Mb0897|M.bovis_AF2122/97 LAARGERAVPVEQMVRDLRINRIFEGSSEIMRLLIAREAVDAHLTAAGDL
Rv0873|M.tuberculosis_H37Rv LAARGERAVPVEQMVRDLRINRIFEGSSEIMRLLIAREAVDAHLTAAGDL
:*: *: :: : **: * :: .
Mflv_4370|M.gilvum_PYR-GCK AKGK----------------------------------------------
MSMEG_0714|M.smegmatis_MC2_155 AAGL----------------------------------------------
TH_4603|M.thermoresistible__bu --------------------------------------------------
Mvan_1476|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MAB_1188c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4660|M.marinum_M AKPNTDLRKKAAAAVGASGFYAKWLPQLVFGEGQRPKAYHEFGPLAAHLR
MUL_0278|M.ulcerans_Agy99 AKPNTDLRKKAAAAVGASGFYAKWLPQLVFGEGQRPKAYHEFGPLAAHLR
MAV_1001|M.avium_104 AKPDAGLREKAAAAVGASGFYAKWLPQLVFGEGQRPRAYHEFGALARHLR
Mb0897|M.bovis_AF2122/97 ANPKADLRQKAAAAAGASGFYAKWLPKLVFGEGQLPTTYREFGALATHLR
Rv0873|M.tuberculosis_H37Rv ANPKADLRQKAAAAAGASGFYAKWLPKLVFGEGQLPTTYREFGALATHLR
Mflv_4370|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0714|M.smegmatis_MC2_155 --------------------------------------------------
TH_4603|M.thermoresistible__bu --------------------------------------------------
Mvan_1476|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MAB_1188c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4660|M.marinum_M FIERSTRKLARNTFYGMARWQAKLEQKQGFLGRIVDIGAELFAMSAVCVR
MUL_0278|M.ulcerans_Agy99 FIERSTRKLARNTFYGMARWQAKLEQKQGFFGRIVDIGAELFAMSAVCVR
MAV_1001|M.avium_104 FIERSSRKLARNTFYGMARWQAKLEQRQGFLGRVVDIGAELFAMSAACVR
Mb0897|M.bovis_AF2122/97 FVERSSRKLARNTFYGMARWQASLEKKQGFLGRIVDIGAELFAISAACVR
Rv0873|M.tuberculosis_H37Rv FVERSSRKLARNTFYGMARWQASLEKKQGFLGRIVDIGAELFAISAACVR
Mflv_4370|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0714|M.smegmatis_MC2_155 --------------------------------------------------
TH_4603|M.thermoresistible__bu --------------------------------------------------
Mvan_1476|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MAB_1188c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4660|M.marinum_M AEAQRVADPIVGRQAYELAEAFCGQATLRVEALFHGLWTNTDVGDVRLTN
MUL_0278|M.ulcerans_Agy99 AEAQRVADPIVGRQAYELAEAFCGQATLRVEALFHGLWTNTDVGDVRLTN
MAV_1001|M.avium_104 AEAQRNADPVLGQQAYELAEAFCAHATLRVEALFQALWDNTDTGDVALTR
Mb0897|M.bovis_AF2122/97 AEAQRTADPVEGEQAYELAEAFCQQATLRVEALFDALWSNTDSIDVRLAN
Rv0873|M.tuberculosis_H37Rv AEAQRTADPVEGEQAYELAEAFCQQATLRVEALFDALWSNTDSIDVRLAN
Mflv_4370|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0714|M.smegmatis_MC2_155 --------------------------------------------------
TH_4603|M.thermoresistible__bu --------------------------------------------------
Mvan_1476|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MAB_1188c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4660|M.marinum_M DVLEGRYAWLEDGIIDPSEGTGPWIAHWEPGPSTQPNVARRFLPDSTSAE
MUL_0278|M.ulcerans_Agy99 DVLEGRYAWLEDGIIDPSEGTGPWIAHWEPGPSTQPNVARRFLPDSTSVE
MAV_1001|M.avium_104 NLQRGRYAWLEDGIIDQSEGSGPWIAHWEEGPSTEANLARRFLTI-----
Mb0897|M.bovis_AF2122/97 DVLEGRYTWLEQGILDQSEGTGPWIASWEPGPSTEANLARRFLTVSPSSE
Rv0873|M.tuberculosis_H37Rv DVLEGRYTWLEQGILDQSEGTGPWIASWEPGPSTEANLARRFLTVSPSSE
Mflv_4370|M.gilvum_PYR-GCK ---
MSMEG_0714|M.smegmatis_MC2_155 ---
TH_4603|M.thermoresistible__bu ---
Mvan_1476|M.vanbaalenii_PYR-1 ---
MLBr_00737|M.leprae_Br4923 ---
MAB_1188c|M.abscessus_ATCC_199 ---
MMAR_4660|M.marinum_M AKL
MUL_0278|M.ulcerans_Agy99 AKL
MAV_1001|M.avium_104 ---
Mb0897|M.bovis_AF2122/97 AKL
Rv0873|M.tuberculosis_H37Rv AKL