For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TATLEHATGLPDAEYRALRDRIFDAIWSELDPLEERIENEERIPNEIVLPILERIGAFGLLVPREYGGSG LSIAQYLPIISEFAKVQGGLRVIVHVHNSFAHALSEIGNDEQKAAVLHGAATGANSVAFALTEPGHGTGA DLGSSAVRMGDEYEITGEKWLITNSDIATHFIVFAKTAPTEVSAFLVPRDTDGLSIEPLPETMGCKGGEH GHIRLAGVRVPATALIGAEGEGNQHLERALEISRVFIAASSLGTSERALELSVARAKERVTFGKPIGSRQ AIQRYLAEMATDIYALRGLLADAAHKWDSGKRIPAEASMCKLFGLEAVGRVTDRALLIHGGIGYTRAYPV ERLYRDARLNWLEEGTPTIQYMVAANELLSGYVFSDAFDAAGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0714 | - | - | 100% (394) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2205 | - | 8e-61 | 37.60% (383) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1991 | - | 8e-51 | 33.33% (375) | isovaleryl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2528c | fadE19 | 5e-49 | 33.59% (390) | acyl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4370 | - | 9e-56 | 36.41% (390) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv2500c | fadE19 | 5e-49 | 33.59% (390) | acyl-CoA dehydrogenase |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-41 | 31.65% (376) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3618c | - | 3e-44 | 32.44% (373) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4034 | fadE | 4e-57 | 38.76% (356) | acyl-CoA dehydrogenase FadE |
| M. avium 104 | MAV_1571 | - | 3e-55 | 37.36% (356) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3736 | - | 4e-60 | 38.16% (380) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4024 | fadE3 | 1e-48 | 34.57% (376) | acyl-CoA dehydrogenase FadE3 |
| M. vanbaalenii PYR-1 | Mvan_1974 | - | 4e-54 | 35.60% (382) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4370|M.gilvum_PYR-GCK -----------MASPPANAAEAGIPSAEVNDEDFQAILAATREFVRTAVV
Mvan_1974|M.vanbaalenii_PYR-1 -----------------------MSTAEVGDEDFRQILAQTRQFVRTAVV
TH_3736|M.thermoresistible__bu MYDIRRPGGVAIAPPGRTHKEKPMSTAEVSDEDFRQILRQTREFVRTAVV
MMAR_4034|M.marinum_M --------------------MT---APQVSDEDFAQILAQTRHFVRSVVL
MAV_1571|M.avium_104 --------------------MTSAEVAEVSEQDFGEILAQTRQFVRTAVV
MSMEG_0714|M.smegmatis_MC2_155 ------------------MTATLEHATGLPDAEYRALRDRIFDAIWSELD
Mb2528c|M.bovis_AF2122/97 -----------------MTTTTTTISGGILPKEYQDLRDTVADFARTVVA
Rv2500c|M.tuberculosis_H37Rv -----------------MTTTTTTISGGILPKEYQDLRDTVADFARTVVA
MLBr_00737|M.leprae_Br4923 ---------------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIA
MAB_3618c|M.abscessus_ATCC_199 ------------------MAGNPSFDLFKLGEEHDELRAAIRGLAEKEIA
MUL_4024|M.ulcerans_Agy99 -------------------MMNNDSPDSQLDEDEAMLVATVRAFIDRDVR
: : :
Mflv_4370|M.gilvum_PYR-GCK PREQEILSTDQVPDDLR-EQTKSMGLFGYAIPQEWGGLGLNLAQDVELAM
Mvan_1974|M.vanbaalenii_PYR-1 PREQEILTTDRVPDELR-EQAKSMGLFGYAIPQEWGGLGLDLTQDVELAM
TH_3736|M.thermoresistible__bu PRELEILNEDRVPDDLR-EQAKQMGLFGYAIPQQWGGLGLDLAQDVELAM
MMAR_4034|M.marinum_M PREQQILDEDRVPEDLR-DQAKQMGLFGYAIPPQWGGLGLNLVQDVELAM
MAV_1571|M.avium_104 PREQEILDGDRVPDDLR-DQAKKMGLFGYAIPQQWGGLGLNLMQDVELAM
MSMEG_0714|M.smegmatis_MC2_155 PLEERIENEERIPNEIVLPILERIGAFGLLVPREYGGSGLSIAQYLPIIS
Mb2528c|M.bovis_AF2122/97 PVSAKHDAEHSFPYEIV-AKMGEMGLFGLPFPEEYGGMGGDYFALSLVLE
Rv2500c|M.tuberculosis_H37Rv PVSAKHDAEHSFPYEIV-AKMGEMGLFGLPFPEEYGGMGGDYFALSLVLE
MLBr_00737|M.leprae_Br4923 PHAADVDQRARFPEEAL-AALNASGFNAIHVPEEYGGQGADSVAACIVIE
MAB_3618c|M.abscessus_ATCC_199 PHAKDVDEKARFPQEAL-DALVASGFNAVHVPEEYDGQGADSVAACIVIE
MUL_4024|M.ulcerans_Agy99 PSVREVEHANTYPQAWI-EQMKRIGIYGLAIGEAYGGSPVSMPCYVQVTQ
* * * . . :.* . :
Mflv_4370|M.gilvum_PYR-GCK ELGYTSLALRSMFGTNNGIAGQVLVGYGTDEQKKTWLERIASGEIVASFA
Mvan_1974|M.vanbaalenii_PYR-1 ELGYTSLALRSMFGTNNGIAGQVLVGYGTDEQKSTWLERIASGEVVASFA
TH_3736|M.thermoresistible__bu ELGYTSLALRSMFGTNNGIAGQVLVGFGTEEQKARWLEPIASGEVVASFA
MMAR_4034|M.marinum_M ELGYTSLAVRSMFGTNNGIAGQVLVGFGTDEQKARWLEPIASGDVVASFA
MAV_1571|M.avium_104 ELGYTSLALRSMFGTNNGIAGQVLVGFGTEAQKARWLEPMAAGDVVASFA
MSMEG_0714|M.smegmatis_MC2_155 EFAKVQGGLRVIVHVHNSFA-HALSEIGNDEQKAAVLHGAATGANSVAFA
Mb2528c|M.bovis_AF2122/97 ELGKVDQSVAITLEAAVGLGAMPIYRFGTEEQKQKWLPDLTSGRALAGFG
Rv2500c|M.tuberculosis_H37Rv ELGKVDQSVAITLEAAVGLGAMPIYRFGTEEQKQKWLPDLTSGRALAGFG
MLBr_00737|M.leprae_Br4923 EVARVDASASL-IPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYA
MAB_3618c|M.abscessus_ATCC_199 EVARVCASSSL-IPAVNKLGTMGLILNGSDELKKQVLPAIASGEAMASYA
MUL_4024|M.ulcerans_Agy99 ELARGWMSLAG-AMGGHTVVAKLLMLFGTDEQKSTYLPAMATGELRATMA
*.. . . : *.: * * :: . .
Mflv_4370|M.gilvum_PYR-GCK LTEPGAGSNPSGLRTKAVRDGDGPHSGWILNGQKRFITNAPN--ADLFVT
Mvan_1974|M.vanbaalenii_PYR-1 LTEPGAGSNPSGLRTKAVRDGDGSCSGWIINGQKRFITNAPN--ANLFVT
TH_3736|M.thermoresistible__bu LTEPGAGSNPAGLRSRAVRDGSGADADWIINGQKRFITNAPV--ADLFVV
MMAR_4034|M.marinum_M LTEPGAGSSPAGLRTKAVRDGD----DWLITGQKRFITNAPV--ADLFVV
MAV_1571|M.avium_104 LTEPGAGSNPAGLRTKAVADGD----NWVISGQKRFITNAPV--ANLFVV
MSMEG_0714|M.smegmatis_MC2_155 LTEPGHGTG-ADLGSSAVRMGD----EYEITGEKWLITNSDI--ATHFIV
Mb2528c|M.bovis_AF2122/97 LTEPGAGSDAGSTRTTARLEG----DEWIINGSKQFITNSGTDITSLVTV
Rv2500c|M.tuberculosis_H37Rv LTEPGAGSDAGSTRTTARLEG----DEWIINGSKQFITNSGTDITSLVTV
MLBr_00737|M.leprae_Br4923 LSEREAGSDAASMRTRAKADG----DDWILNGFKCWITNGGK--STWYTV
MAB_3618c|M.abscessus_ATCC_199 LSEREAGSDAASMRTRAKADG----DDWIINGSKCWITNGGK--SSWYTV
MUL_4024|M.ulcerans_Agy99 LTEPGGGSDLQNMSTTAMADGP---DQLLITGAKTWISNARR--SGLIAL
*:* *:. . : * * :.* * *:*. :
Mflv_4370|M.gilvum_PYR-GCK FARSRPADD---KGAGIAVFLVPADTPGVDIGAKDKKMGQEGAWTADVNF
Mvan_1974|M.vanbaalenii_PYR-1 FARSRPADD---KGAGIAVFLVPADTPGVEVGAKDKKMGQEGAWTADVNF
TH_3736|M.thermoresistible__bu FARSRPADE---RGAGIAVFLVPADAPGVEVGAKDAKMGQEGAWTADVTF
MMAR_4034|M.marinum_M FARTRPASD---KSPGIAVFLVPAQSAGVEVGAKDAKMGQEGAWTADVSF
MAV_1571|M.avium_104 FARTRPADD---QGPGIAVFLVPADAAGVQIGAKDAKMGQEGAWTADVSF
MSMEG_0714|M.smegmatis_MC2_155 FAKTAPT--------EVSAFLVPRDTDGLSIEPLPETMGCKGGEHGHIRL
Mb2528c|M.bovis_AF2122/97 TAVTGTTGTAADAKKEISTIIVPSGTPGFTVEPVYNKVGWNASDTHPLTF
Rv2500c|M.tuberculosis_H37Rv TAVTGTTGTAADAKKEISTIIVPSGTPGFTVEPVYNKVGWNASDTHPLTF
MLBr_00737|M.leprae_Br4923 MAVTDPD----KGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYF
MAB_3618c|M.abscessus_ATCC_199 MAVTDPE----KKANGISAFMVHKDDEGFTVGPLEHKLGIKGSPTAELYF
MUL_4024|M.ulcerans_Agy99 LCKTDPHAT--PRHHGISIVLVEPG-PGLNISADLPKLGYKGVEACELSF
. : . :: .:* *. : . .:* :. : :
Mflv_4370|M.gilvum_PYR-GCK TDVEVPDTALVGGSEDLGYRAAMTSLARGRVHIAALAVGAAQRALDESVA
Mvan_1974|M.vanbaalenii_PYR-1 TDVRVPDAALVGGSEDIGYRAAMTSLARGRVHIAALAVGAAQRALDESVT
TH_3736|M.thermoresistible__bu TDVRVPASALVGGEEDIGYRAAMTSLARGRVHIAALAVGTAQRALDESVA
MMAR_4034|M.marinum_M TDVRVDDAALVGGSEDIGYRAAMTSLARGRVHIAAIAVGAAQRALDESVA
MAV_1571|M.avium_104 DDVRVGGDALIGGSEDIGYRAAMTSLARGRVHIAALAVGAAQRALDESVS
MSMEG_0714|M.smegmatis_MC2_155 AGVRVPATALIG-AEGEGNQHLERALEISRVFIAASSLGTSERALELSVA
Mb2528c|M.bovis_AF2122/97 ADARVPRENLLG-ARGSGYANFLSILDEGRIAIAALATGAAQGCVDESVK
Rv2500c|M.tuberculosis_H37Rv ADARVPRENLLG-ARGSGYANFLSILDEGRIAIAALATGAAQGCVDESVK
MLBr_00737|M.leprae_Br4923 DKCRIPGDRIIG-EPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIV
MAB_3618c|M.abscessus_ATCC_199 ENCRIPGDRIIG-EPGTGFKTALQTLDHTRPTIGAQALGIAQGALDQAIA
MUL_4024|M.ulcerans_Agy99 DNYRAPTSAILGGQPGQGFSQMMKGLETGRIQVAARALGVASAALDDALA
. ::* . * * * :.* : * :. .:: ::
Mflv_4370|M.gilvum_PYR-GCK YAATATQGGTPIGDFQLVQAMLADQQTGVMAGRALVRDAARLWVTGQD-R
Mvan_1974|M.vanbaalenii_PYR-1 YAATATQGGTAIGDFQLVQAMLADQQTGVMAGRALVRETARQWVTGED-R
TH_3736|M.thermoresistible__bu YAASATQGGTPIGQFQLVQAMLADQQTGVMAGRALVRDAARKWVSGED-R
MMAR_4034|M.marinum_M YASTATQGGVTIGSFQLVQAMLADQQTGVLAGRALVRDAARMWVSGAD-R
MAV_1571|M.avium_104 YASTATQGGTPIGNFQLVQAMLADQQTEVLAGRALVREAARLWVTGED-R
MSMEG_0714|M.smegmatis_MC2_155 RAKERVTFGKPIGSRQAIQRYLAEMATDIYALRGLLADAAHKWDSGKR-I
Mb2528c|M.bovis_AF2122/97 YANQRQSFGQPIGAYQAIGFKIARMEARAHVARTAYYDAAAKMLAGKP-F
Rv2500c|M.tuberculosis_H37Rv YANQRQSFGQPIGAYQAIGFKIARMEARAHVARTAYYDAAAKMLAGKP-F
MLBr_00737|M.leprae_Br4923 YTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDL
MAB_3618c|M.abscessus_ATCC_199 YTKDRKQFGKSISDFQGVQFMLADMAMKVEAARLMVYTAAARAERGEKNL
MUL_4024|M.ulcerans_Agy99 YAQQRHSFGQPIWKHQAIGNYLADMATKLTAARQLTHYAAQRYDSGQR-C
: * .* * : :* . * :* *
Mflv_4370|M.gilvum_PYR-GCK RIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRDVRLLRLY
Mvan_1974|M.vanbaalenii_PYR-1 RIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRDVRLLRLY
TH_3736|M.thermoresistible__bu RVAPSAAKLFCTEMAGQVADLAVQIHGGTGYMREVPVERIYRDVRLLRLY
MMAR_4034|M.marinum_M RIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMRGVPVERIYRDVRLLRLY
MAV_1571|M.avium_104 RVAPSAAKLYCTEMAGRVADLAVQVHGGSGYMRGVPVERIYRDVRLLRLY
MSMEG_0714|M.smegmatis_MC2_155 PAEASMCKLFGLEAVGRVTDRALLIHGGIGYTRAYPVERLYRDARLNWLE
Mb2528c|M.bovis_AF2122/97 KKEAAIAKMISSEAAMDNSRDATQIHGGYGFMNEYPVARHYRDSKVLEIG
Rv2500c|M.tuberculosis_H37Rv KKEAAIAKMISSEAAMDNSRDATQIHGGYGFMNEYPVARHYRDSKVLEIG
MLBr_00737|M.leprae_Br4923 GFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIY
MAB_3618c|M.abscessus_ATCC_199 GFISSASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERMMRDAKITQIY
MUL_4024|M.ulcerans_Agy99 DMEAGMAKLFASETAMEIALNAVRIHGGYGYSTEYDVERYFRDAPLMIVG
.. .* : . : * :.** *: * * ** : :
Mflv_4370|M.gilvum_PYR-GCK EGTSEIQKLIIGGGLVKGAKGK--------
Mvan_1974|M.vanbaalenii_PYR-1 EGTSEIQRLIIGGGLVKGAKAR--------
TH_3736|M.thermoresistible__bu EGTSEIQRLIIGGGLVKAAQRQTN------
MMAR_4034|M.marinum_M EGTSEIQQLIIGSNLIKAANR---------
MAV_1571|M.avium_104 EGTSEIQRLIIGSNLVKAAQRATTTKER--
MSMEG_0714|M.smegmatis_MC2_155 EGTPTIQYMVAANELLSGYVFSDAFDAAGL
Mb2528c|M.bovis_AF2122/97 EGTTEVQLMLIARSLGLQ------------
Rv2500c|M.tuberculosis_H37Rv EGTTEVQLMLIARSLGLQ------------
MLBr_00737|M.leprae_Br4923 EGTNQIQRVVMSRALLR-------------
MAB_3618c|M.abscessus_ATCC_199 EGTNQIQRVVMSRALLTS------------
MUL_4024|M.ulcerans_Agy99 EGTNEIQRNVIARQLIARGGI---------
*** :* : . *