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VNTELPQDIIEFARVAAKRLARVGGPPAALRAETDDGIRRAARAALDDLGAFELDVRSGPDDLLAAAVLC RAAGALAIPYPLVEELLSVDGARLALVNPDLPRIDHGDLPGSWIAADLDGARYRPQPAARTAAKLGPFLV PATLGAPEGTVAASDIDLHLVLGSWRILGAVQQSLDIVTAHVRTRIQFGKALADFQAVRFCVADAAVAVR GLAELAKYTISRTESYAARVRSADALLLRLKAADTARQVLRISHQLLGALGFCDESDISVLDRHTQPLIR LPLCAEALAIRLIPDAADGSLETLFSAPVSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3982 | - | - | 100% (311) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4719 | - | 6e-11 | 35.48% (155) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_3512 | - | 2e-08 | 26.83% (205) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3594 | fadE33 | 3e-07 | 23.57% (263) | acyl-CoA dehydrogenase FADE33 |
| M. gilvum PYR-GCK | Mflv_1793 | - | 4e-44 | 38.51% (309) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3564 | fadE33 | 3e-07 | 23.57% (263) | acyl-CoA dehydrogenase FADE33 |
| M. leprae Br4923 | MLBr_00661 | fadE24 | 2e-06 | 33.33% (135) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0594c | - | 2e-10 | 30.32% (277) | acyl-CoA dehydrogenase FadE |
| M. avium 104 | MAV_1628 | - | 1e-136 | 78.14% (311) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5621 | - | 1e-43 | 40.00% (285) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_0680 | - | 1e-37 | 35.93% (295) | putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_3843 | - | 1e-168 | 96.46% (311) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4957 | - | 6e-42 | 37.99% (308) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3982|M.marinum_M --------------------------------------------------
MUL_3843|M.ulcerans_Agy99 --------------------------------------------------
MAV_1628|M.avium_104 --------------------------------------------------
Mflv_1793|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4957|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5621|M.smegmatis_MC2_155 --------------------------------------------------
TH_0680|M.thermoresistible__bu --------------------------------------------------
Mb3594|M.bovis_AF2122/97 --------------------------------------------------
Rv3564|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0594c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00661|M.leprae_Br4923 MTDTAPSAKPSSVRLKRGGLRSGVGMQPHKRTGFDVAIAMLTPLVGQDFL
MMAR_3982|M.marinum_M --------------------------------------------------
MUL_3843|M.ulcerans_Agy99 --------------------------------------------------
MAV_1628|M.avium_104 --------------------------------------------------
Mflv_1793|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4957|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5621|M.smegmatis_MC2_155 --------------------------------------------------
TH_0680|M.thermoresistible__bu -----------------------------------------------MDG
Mb3594|M.bovis_AF2122/97 --------------------------------------------------
Rv3564|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0594c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00661|M.leprae_Br4923 DKYHLRYPLNRALRYGVKATFSTAAATSRQFKRVQNLRGGATRLQPSGRN
MMAR_3982|M.marinum_M -MNTELPQDIIEFARVAAKRLARVGGPPAALRAETDD-----GIRRAAR-
MUL_3843|M.ulcerans_Agy99 -MNTELPQDVIDFARVAAKRLARVGGPPAALRAETDD-----GIRRAAC-
MAV_1628|M.avium_104 -MKTDLPQDISDFATVAAKRFTRLGGPPAALRAETDD-----TVREAAR-
Mflv_1793|M.gilvum_PYR-GCK -MILDLSDDALEFGRQALHAFENAGGDRLAEQAEADP-----AARQTLVA
Mvan_4957|M.vanbaalenii_PYR-1 -MILDLSDDALEYGLQALHAFENAGGDRLVEQAEADP-----TARHGLVR
MSMEG_5621|M.smegmatis_MC2_155 -MILDLSDDAEEFGHQALRAFESAGGDELLQQAEAKP-----DARQGLVG
TH_0680|M.thermoresistible__bu PMILDLSDDALEYGRQALRAFEAAGGDELVLQADAKP-----ENREALVG
Mb3594|M.bovis_AF2122/97 ---MTPPEERQMLRETVASLVAKHAGPAAVRAAMASDR----GYDESLWR
Rv3564|M.tuberculosis_H37Rv ---MTPPEERQMLRETVASLVAKHAGPAAVRAAMASDR----GYDESLWR
MAB_0594c|M.abscessus_ATCC_199 -MKFDLDTQQRDFAASIDAALSVADVPAAARAWAAGN-----HGPGLAVW
MLBr_00661|M.leprae_Br4923 YFDLTPDDNQKLIVETIDEFSAEILRPAAHDADEAAAYPPDLIAKAAKLG
: :
MMAR_3982|M.marinum_M AALDDLGAFELDVRSGPD----DLLAAAVLCRAAG---------------
MUL_3843|M.ulcerans_Agy99 AALDDLGAFELDVRSGPD----DLLAAAVLCRAAG---------------
MAV_1628|M.avium_104 TALAEVGAFDLDVRTAPD----DLLAAAVLCQAAG---------------
Mflv_1793|M.gilvum_PYR-GCK PVLDGLGAWDLDPRTDPD----GLEAAAALCRSAG---------------
Mvan_4957|M.vanbaalenii_PYR-1 PVLDGLGAWDLDPRTDAD----GLEAAAALCRSAG---------------
MSMEG_5621|M.smegmatis_MC2_155 PVLDGLGAWDLDPRSDAD----ALEAAAALCRSAG---------------
TH_0680|M.thermoresistible__bu PVLTGLDAWDLDPRTDLD----GAEAAAALCRSAG---------------
Mb3594|M.bovis_AF2122/97 LLCEQVGAAALVIPEELGGAGGELADAAIVVQELG---------------
Rv3564|M.tuberculosis_H37Rv LLCEQVGAAALVIPEELGGAGGELADAAIVVQELG---------------
MAB_0594c|M.abscessus_ATCC_199 STLAELGVTALAVSEKYDGIGAHPVDLVVALEGLG---------------
MLBr_00661|M.leprae_Br4923 ITTINIPEYFDGIAERRSSVTNVLVAEALAYGDMGLTLPILAPGGVAATL
: . . *
MMAR_3982|M.marinum_M --------------------------ALAIPYPLVEE-------LLS---
MUL_3843|M.ulcerans_Agy99 --------------------------TVALPYPLVEE-------LLS---
MAV_1628|M.avium_104 --------------------------AAALPYPLVEE-------LLA---
Mflv_1793|M.gilvum_PYR-GCK --------------------------YWAVPYPLAER-------LAAPTD
Mvan_4957|M.vanbaalenii_PYR-1 --------------------------YWALPYPLAER-------LAKPAD
MSMEG_5621|M.smegmatis_MC2_155 --------------------------YWALPYPVAER-------LARPTD
TH_0680|M.thermoresistible__bu --------------------------YWALPYPVAER-------LSRPTD
Mb3594|M.bovis_AF2122/97 --------------------------RALVPSPLLGTT-LAELALLAAAK
Rv3564|M.tuberculosis_H37Rv --------------------------RALVPSPLLGTT-LAELALLAAAK
MAB_0594c|M.abscessus_ATCC_199 --------------------------KWAVPGPVVESV-AVAPVLLSSHE
MLBr_00661|M.leprae_Br4923 TYWGSADQQATYLKEFTGENVPQACVAIAEPQPLFDPTRLKTIAVRTPSG
* *: :
MMAR_3982|M.marinum_M VDGARLALVNP---------------DLPRIDHGDLPGSWIAADLDGARY
MUL_3843|M.ulcerans_Agy99 IDGARLALVNP---------------DLPRIDHGDLPGSWIAADLDGARY
MAV_1628|M.avium_104 IDGARLTLVNP---------------AAPRIDHGDLAGDWIAADIDGNRY
Mflv_1793|M.gilvum_PYR-GCK LDVDGLLVIPA---------------TRPSAPVAGLDLRWAAVDLDGRRS
Mvan_4957|M.vanbaalenii_PYR-1 LDVDGLVVVGG---------------PRPAAALGGLDLRWAAVDLDGRRA
MSMEG_5621|M.smegmatis_MC2_155 LDVDGLIVVAD---------------GTPEAALAGLDLRWAAVTLDGTRS
TH_0680|M.thermoresistible__bu LDVDGLIVVDA---------------AAPLGGVAGVRLRWATVDLTGRRA
Mb3594|M.bovis_AF2122/97 PDAQALTELAQGSA------IGALVLDPDYVVNGDIADIVVAATSGQLTR
Rv3564|M.tuberculosis_H37Rv PDAQALTELAQGSA------IGALVLDPDYVVNGDIADIVVAATSGQLTR
MAB_0594c|M.abscessus_ATCC_199 DGAEPSTRLASGEL------IATVAAPPIAPRALDADIAGLVLIADDIGI
MLBr_00661|M.leprae_Br4923 YRLDGVKSLVPAAASAELFIIGAQLNGKPALFIVESSTKGLTVKADPSMG
: .
MMAR_3982|M.marinum_M RPQPAARTAAKLGPFLVPATLGAPEGTVAASD---IDLHLVLGSWRILGA
MUL_3843|M.ulcerans_Agy99 RPQPAARTAAKLGPFLVPATLGAPEGTVAASD---IDLHLVLGSWRILGA
MAV_1628|M.avium_104 RPRPGSRTGAKLGPFLVPATLSAPEGTVPGAD---VNLHLVLGAWRILGA
Mflv_1793|M.gilvum_PYR-GCK ----TVTGHGEPGPAFVAELELSPVDDAGGPE---LALALVLPSWTLLGM
Mvan_4957|M.vanbaalenii_PYR-1 ----LVTGQGVTGPGFVAELELSPVDSDGSRD---VALALVLPCWTLLGI
MSMEG_5621|M.smegmatis_MC2_155 ----TVTRLGATGPAFTTALDLVEIDAQGAGD---VALGLVLGSWTLLGL
TH_0680|M.thermoresistible__bu ----DVTQVVGAGPGFTARLETTPLDEAGGDD---IALALVLSGWTLLGM
Mb3594|M.bovis_AF2122/97 WTRFSAQPVATMDPTRRLARLQSEETEPLCPDPGIADTAAILLAAEQIGA
Rv3564|M.tuberculosis_H37Rv WTRFSAQPVATMDPTRRLARLQSEETEPLCPDPGIADTAAILLAAEQIGA
MAB_0594c|M.abscessus_ATCC_199 REAQAGAQHESIDATRRVFDVQPKEAGISLDTSRAIDFGVLAISAQLIGA
MLBr_00661|M.leprae_Br4923 IRAAALGQVELCGVSAPLDARLGEDDATDNDYSEAIALARLGWAALAVGT
. : :*
MMAR_3982|M.marinum_M VQQSLDIVTAHVRTRIQFGKALADFQAVRFCVADAAVAVRGLAELAKYTI
MUL_3843|M.ulcerans_Agy99 VQQTLDIVTAHVRTRIQLGKALADFQTVRFCVANAAVAVRGLAELAKYTI
MAV_1628|M.avium_104 VQQSLRIVTDHVQARIQFGKPLADFQAVRFAVADAAVMVRGLHELAKYTI
Mflv_1793|M.gilvum_PYR-GCK LDRALALTVSHVGLRKQFGQTLSSFQGVQFQLTDAEVERSGVDILAKHAL
Mvan_4957|M.vanbaalenii_PYR-1 LDRAVALTVAHVSLRKQFGQTLSSFQGVQFQLTDAEVERSGVDILAKHAL
MSMEG_5621|M.smegmatis_MC2_155 LDRAVDLTVAHVSLRKQFGQTLSSFQGVQFQLTDAEVERSGVDILAKHAL
TH_0680|M.thermoresistible__bu LDRAIGLTVEHVRLREQFGQPLARFQGVQFQLTDAEVERSGTDILAKHAL
Mb3594|M.bovis_AF2122/97 AERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADLYVTIAAARAVVADAC
Rv3564|M.tuberculosis_H37Rv AERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADLYVTIAAARAVVADAC
MAB_0594c|M.abscessus_ATCC_199 GQALLDRAVAYAKQRSQFGRPIGSYQAVKHKLADVHIALELARPLVYGAA
MLBr_00661|M.leprae_Br4923 SHAVLDYVMPYVKEREAFGEPIARRQAVAFMCANIAIELDGLRLITWRGA
. : . :. * :*..:. * : . :: : :.
MMAR_3982|M.marinum_M SRTESYAARVRSADALLLRLKAADTARQVLRISHQLLGALGFCDESDISV
MUL_3843|M.ulcerans_Agy99 SRTESYAARVRSADALLLRLKAADTARQVLRISHQLLGALGFCDESDISV
MAV_1628|M.avium_104 CRPESLPAQVHSADALVLRLKAADTARQVMRTSHQLLGALGFCDESDVSV
Mflv_1793|M.gilvum_PYR-GCK WSIA-TDQPQAVDDALALRLAALEAAEVVFRVCHQLHGAAGFCDETTLSW
Mvan_4957|M.vanbaalenii_PYR-1 WSIA-TDQSHVVDDALALRMAAIEAADVVFRVCHQLHGAVGFCDETTLSW
MSMEG_5621|M.smegmatis_MC2_155 WGLTRHDTTEVVDDALALRLAAIEAAEVVFRVCHQLHGAVGFCDETTLSW
TH_0680|M.thermoresistible__bu WSVS-TGQPGALEDALSFRMAALEAAEVVFRVCHQLHGAVGFCDETTLSW
Mb3594|M.bovis_AF2122/97 HAPT-------PTNAATARLAASEALSTAAAEGIQLHGGIAITWEHDMHL
Rv3564|M.tuberculosis_H37Rv HAPT-------PTNAATARLAASEALSTAAAEGIQLHGGIAITWEHDMHL
MAB_0594c|M.abscessus_ATCC_199 LSLA-DQSPTAARDASAAKVAAAKAAYLAARSALQTHGAIGFTAEYDLSL
MLBr_00661|M.leprae_Br4923 SRAE--QGLSFAREAALAKRLGSDKAMQIGLDGVQLLGGHGFIKEHPVER
:* : . . * *. .: * :
MMAR_3982|M.marinum_M LDRHTQPLIRLPLCAEALAIRLIPDAADGSLETLFSAPVSA
MUL_3843|M.ulcerans_Agy99 LDRHTQPLIRLPLCAEALAIRLIPDAADGSLETLFSAPVSA
MAV_1628|M.avium_104 LDRHTQPLIRLPLSTEELALRLIPSVADGAFETLFSEPVSA
Mflv_1793|M.gilvum_PYR-GCK LSRYSQPLRRLPFGLSATRDHLTRLAGRRGLAGLYT-----
Mvan_4957|M.vanbaalenii_PYR-1 LSRYSLPLRRLPFGLSSTRDHLTRVAGRRGLTGLFI-----
MSMEG_5621|M.smegmatis_MC2_155 LSRHSQPLRRLPFGISTTRDILTRRVGRRGLTGLFS-----
TH_0680|M.thermoresistible__bu LSRYSQPLRRLPLGVSATRAELSRRLGRRGLTGLYA-----
Mb3594|M.bovis_AF2122/97 YFKRAHGSAQLLESPREVLRRLESEVWESP-----------
Rv3564|M.tuberculosis_H37Rv YFKRAHGSAQLLESPREVLRRLESEVWESP-----------
MAB_0594c|M.abscessus_ATCC_199 WILKVRALTSAWGTSEWHRARVLEAL---------------
MLBr_00661|M.leprae_Br4923 WYRDLRAIGVAEGVVVI------------------------