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VILDLSDDALEFGRQALHAFENAGGDRLAEQAEADPAARQTLVAPVLDGLGAWDLDPRTDPDGLEAAAAL CRSAGYWAVPYPLAERLAAPTDLDVDGLLVIPATRPSAPVAGLDLRWAAVDLDGRRSTVTGHGEPGPAFV AELELSPVDDAGGPELALALVLPSWTLLGMLDRALALTVSHVGLRKQFGQTLSSFQGVQFQLTDAEVERS GVDILAKHALWSIATDQPQAVDDALALRLAALEAAEVVFRVCHQLHGAAGFCDETTLSWLSRYSQPLRRL PFGLSATRDHLTRLAGRRGLAGLYT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1793 | - | - | 100% (305) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1550 | - | 3e-12 | 26.73% (303) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1509 | - | 2e-11 | 30.61% (147) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3574c | fadE28 | 7e-12 | 36.89% (103) | acyl-CoA dehydrogenase FADE28 |
| M. tuberculosis H37Rv | Rv3544c | fadE28 | 7e-12 | 36.89% (103) | acyl-CoA dehydrogenase FADE28 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-05 | 28.03% (132) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4159 | - | 1e-12 | 25.33% (300) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_3982 | - | 5e-44 | 38.51% (309) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1628 | - | 2e-42 | 39.44% (284) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5621 | - | 1e-130 | 76.14% (306) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_0680 | - | 1e-127 | 73.68% (304) | putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_3843 | - | 4e-42 | 37.22% (309) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4957 | - | 1e-146 | 83.55% (304) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1793|M.gilvum_PYR-GCK ------------------------------------MILDLS--------
Mvan_4957|M.vanbaalenii_PYR-1 ------------------------------------MILDLS--------
MSMEG_5621|M.smegmatis_MC2_155 ------------------------------------MILDLS--------
TH_0680|M.thermoresistible__bu --------------------------------MDGPMILDLS--------
MMAR_3982|M.marinum_M ------------------------------------MNTELP--------
MUL_3843|M.ulcerans_Agy99 ------------------------------------MNTELP--------
MAV_1628|M.avium_104 ------------------------------------MKTDLP--------
Mb3574c|M.bovis_AF2122/97 ---------MDFDPTAEQQAVA--------DVVTSVLERDIS--------
Rv3544c|M.tuberculosis_H37Rv ---------MDFDPTAEQQAVA--------DVVTSVLERDIS--------
MAB_4159|M.abscessus_ATCC_1997 ---------MDFSLTEAQTDLAGLTRTIASTISTPERQKELDKQDSRFDR
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQR-ARFPE
::
Mflv_1793|M.gilvum_PYR-GCK --DDALEFG-RQALHAFENAGGD---RLAEQAEADPAARQTLVAPVLDGL
Mvan_4957|M.vanbaalenii_PYR-1 --DDALEYG-LQALHAFENAGGD---RLVEQAEADPTARHGLVRPVLDGL
MSMEG_5621|M.smegmatis_MC2_155 --DDAEEFG-HQALRAFESAGGD---ELLQQAEAKPDARQGLVGPVLDGL
TH_0680|M.thermoresistible__bu --DDALEYG-RQALRAFEAAGGD---ELVLQADAKPENREALVGPVLTGL
MMAR_3982|M.marinum_M --QDIIEFA-RVAAKRLARVGGP---PAALRAETDDGIRRAAR-AALDDL
MUL_3843|M.ulcerans_Agy99 --QDVIDFA-RVAAKRLARVGGP---PAALRAETDDGIRRAAC-AALDDL
MAV_1628|M.avium_104 --QDISDFA-TVAAKRFTRLGGP---PAALRAETDDTVREAAR-TALAEV
Mb3574c|M.bovis_AF2122/97 --WEALVCGGVTALPVPERLGGDGVGLFEVGALLTEVGRHGAVTPALATL
Rv3544c|M.tuberculosis_H37Rv --WEALVCGGVTALPVPERLGGDGVGLFEVGALLTEVGRHGAVTPALATL
MAB_4159|M.abscessus_ATCC_1997 QLWTKLAEADILSTAAPESVGGAGFGVLEQSSILVELGRELAAVPYLESV
MLBr_00737|M.leprae_Br4923 EALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAV
. : ** * . : :
Mflv_1793|M.gilvum_PYR-GCK G-AWDLDPRTD-PDGLEAAAALCRSAGYWAVPYPLAER-----LAAPTDL
Mvan_4957|M.vanbaalenii_PYR-1 G-AWDLDPRTD-ADGLEAAAALCRSAGYWALPYPLAER-----LAKPADL
MSMEG_5621|M.smegmatis_MC2_155 G-AWDLDPRSD-ADALEAAAALCRSAGYWALPYPVAER-----LARPTDL
TH_0680|M.thermoresistible__bu D-AWDLDPRTD-LDGAEAAAALCRSAGYWALPYPVAER-----LSRPTDL
MMAR_3982|M.marinum_M G-AFELDVRSG-PDDLLAAAVLCRAAGALAIPYPLVEE-----LLS---V
MUL_3843|M.ulcerans_Agy99 G-AFELDVRSG-PDDLLAAAVLCRAAGTVALPYPLVEE-----LLS---I
MAV_1628|M.avium_104 G-AFDLDVRTA-PDDLLAAAVLCQAAGAAALPYPLVEE-----LLA---I
Mb3574c|M.bovis_AF2122/97 G-LGVVPLLEL-ASAEQQDRFLAGVAKGGVLTAALNEP-----GAALPDR
Rv3544c|M.tuberculosis_H37Rv G-LGVVPLLEL-ASAEQQDRFLAGVAKGGVLTAALNEP-----GAALPDR
MAB_4159|M.abscessus_ATCC_1997 V-LAAGALAAFGSEAMRNDWAAPAVAGKKVLTIALEGE-----PGEGPVA
MLBr_00737|M.leprae_Br4923 NKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTR
. * . .:
Mflv_1793|M.gilvum_PYR-GCK DVDGLLVIPATRPSAPVA-GLDLRWAAVDLD-----GRRS----TVTGHG
Mvan_4957|M.vanbaalenii_PYR-1 DVDGLVVVGGPRPAAALG-GLDLRWAAVDLD-----GRRA----LVTGQG
MSMEG_5621|M.smegmatis_MC2_155 DVDGLIVVADGTPEAALA-GLDLRWAAVTLD-----GTRS----TVTRLG
TH_0680|M.thermoresistible__bu DVDGLIVVDAAAPLGGVA-GVRLRWATVDLT-----GRRA----DVTQVV
MMAR_3982|M.marinum_M DGARLALVNPDLPRIDHG-DLPGSWIAADLD-----GARYRPQPAARTAA
MUL_3843|M.ulcerans_Agy99 DGARLALVNPDLPRIDHG-DLPGSWIAADLD-----GARYRPQPAARTAA
MAV_1628|M.avium_104 DGARLTLVNPAAPRIDHG-DLAGDWIAADID-----GNRYRPRPGSRTGA
Mb3574c|M.bovis_AF2122/97 PATSFVGGRLSGTKVGVGYAEQADWMLVTAD-----NAVVVVSPTADGVR
Rv3544c|M.tuberculosis_H37Rv PATSFVGGRLSGTKVGVGYAEQADWMLVTAD-----NAVVVVSPTADGVR
MAB_4159|M.abscessus_ATCC_1997 ARTEGTGYVLTGNRVLVPFGVEADAYLVPAE-----TETGTAVFLVSADD
MLBr_00737|M.leprae_Br4923 AKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDD
.
Mflv_1793|M.gilvum_PYR-GCK ---EPGP--------------AFVAELELSPVDDAGGPELALALVLPS--
Mvan_4957|M.vanbaalenii_PYR-1 ---VTGP--------------GFVAELELSPVDSDGSRDVALALVLPC--
MSMEG_5621|M.smegmatis_MC2_155 ---ATGP--------------AFTTALDLVEIDAQGAGDVALGLVLGS--
TH_0680|M.thermoresistible__bu ---GAGP--------------GFTARLETTPLDEAGGDDIALALVLSG--
MMAR_3982|M.marinum_M ---KLGP--------------FLVPATLGAPEGTVAASDIDLHLVLGS--
MUL_3843|M.ulcerans_Agy99 ---KLGP--------------FLVPATLGAPEGTVAASDIDLHLVLGS--
MAV_1628|M.avium_104 ---KLGP--------------FLVPATLSAPEGTVPGADVNLHLVLGA--
Mb3574c|M.bovis_AF2122/97 ---MVRTPTSNGSDEYVMTMDGVAVADCDILADVAAHRVNQLALAVMG--
Rv3544c|M.tuberculosis_H37Rv ---MVRTPTSNGSDEYVMTMDGVAVADCDILADVAAHRVNQLALAVMG--
MAB_4159|M.abscessus_ATCC_1997 ---AGVTQQALHTTGKDSSAELILSEVPVPAERKVGGAEVVEWLRLRESL
MLBr_00737|M.leprae_Br4923 EGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLD
. :
Mflv_1793|M.gilvum_PYR-GCK -------WTLLGMLDRALALTVSHVGLRKQFGQTLSSFQGVQFQLTDAEV
Mvan_4957|M.vanbaalenii_PYR-1 -------WTLLGILDRAVALTVAHVSLRKQFGQTLSSFQGVQFQLTDAEV
MSMEG_5621|M.smegmatis_MC2_155 -------WTLLGLLDRAVDLTVAHVSLRKQFGQTLSSFQGVQFQLTDAEV
TH_0680|M.thermoresistible__bu -------WTLLGMLDRAIGLTVEHVRLREQFGQPLARFQGVQFQLTDAEV
MMAR_3982|M.marinum_M -------WRILGAVQQSLDIVTAHVRTRIQFGKALADFQAVRFCVADAAV
MUL_3843|M.ulcerans_Agy99 -------WRILGAVQQTLDIVTAHVRTRIQLGKALADFQTVRFCVANAAV
MAV_1628|M.avium_104 -------WRILGAVQQSLRIVTDHVQARIQFGKPLADFQAVRFAVADAAV
Mb3574c|M.bovis_AF2122/97 -------AYADGLVAGALRLTADYVANRKQFGKPLSTFQTVAAQLAEVYI
Rv3544c|M.tuberculosis_H37Rv -------AYADGLVAGALRLTADYVANRKQFGKPLSTFQTVAAQLAEVYI
MAB_4159|M.abscessus_ATCC_1997 GH----SAYQLGVLERALELTADYARTREQFGKPIGGFQAVAQRLADGYI
MLBr_00737|M.leprae_Br4923 HTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAM
* :: . :. * *:*:.:. ** : ::: :
Mflv_1793|M.gilvum_PYR-GCK ERSGVDILAKHALWSIA-TDQPQAVDDALALRLAALEAAEVVFRVCHQLH
Mvan_4957|M.vanbaalenii_PYR-1 ERSGVDILAKHALWSIA-TDQSHVVDDALALRMAAIEAADVVFRVCHQLH
MSMEG_5621|M.smegmatis_MC2_155 ERSGVDILAKHALWGLTRHDTTEVVDDALALRLAAIEAAEVVFRVCHQLH
TH_0680|M.thermoresistible__bu ERSGTDILAKHALWSVS-TGQPGALEDALSFRMAALEAAEVVFRVCHQLH
MMAR_3982|M.marinum_M AVRGLAELAKYTISRTESYAARVRSADALLLRLKAADTARQVLRISHQLL
MUL_3843|M.ulcerans_Agy99 AVRGLAELAKYTISRTESYAARVRSADALLLRLKAADTARQVLRISHQLL
MAV_1628|M.avium_104 MVRGLHELAKYTICRPESLPAQVHSADALVLRLKAADTARQVMRTSHQLL
Mb3574c|M.bovis_AF2122/97 ASRTIDLVAKSVIWRLA--EDLDAGDDLGVLGYWVTSQAPPAMQICHHLH
Rv3544c|M.tuberculosis_H37Rv ASRTIDLVAKSVIWRLA--EDLDAGDDLGVLGYWVTSQAPPAMQICHHLH
MAB_4159|M.abscessus_ATCC_1997 DVKGLCLTLWQAAWRVS--EDLPSDVDVATAKFWAADAGHRVAHTAVHVH
MLBr_00737|M.leprae_Br4923 KVEAARLIVYAAAARAE-RGEPDLGFISAASKCFASDIAMEVTTDAVQLF
. . . . . . ::
Mflv_1793|M.gilvum_PYR-GCK GAAGFCDETTLSWLSRYSQPLRRLPFGLSATRDHLTRLAGRRGLAGLYT-
Mvan_4957|M.vanbaalenii_PYR-1 GAVGFCDETTLSWLSRYSLPLRRLPFGLSSTRDHLTRVAGRRGLTGLFI-
MSMEG_5621|M.smegmatis_MC2_155 GAVGFCDETTLSWLSRHSQPLRRLPFGISTTRDILTRRVGRRGLTGLFS-
TH_0680|M.thermoresistible__bu GAVGFCDETTLSWLSRYSQPLRRLPLGVSATRAELSRRLGRRGLTGLYA-
MMAR_3982|M.marinum_M GALGFCDESDISVLDRHTQPLIRLPLCAEALAIRLIPDAADGSLETLFSA
MUL_3843|M.ulcerans_Agy99 GALGFCDESDISVLDRHTQPLIRLPLCAEALAIRLIPDAADGSLETLFSA
MAV_1628|M.avium_104 GALGFCDESDVSVLDRHTQPLIRLPLSTEELALRLIPSVADGAFETLFSE
Mb3574c|M.bovis_AF2122/97 GGMGMD---VTYPMHRYYSTIKDLTRLLGGPSHRLELLGARCSLT-----
Rv3544c|M.tuberculosis_H37Rv GGMGMD---VTYPMHRYYSTIKDLTRLLGGPSHRLELLGARCSLT-----
MAB_4159|M.abscessus_ATCC_1997 GGVGID---EDHPVHRYFLAAKRGEFASGSATEQLRRIGRELADTPA---
MLBr_00737|M.leprae_Br4923 GGAGYT---SDFPVERFMRDAKITQIYEG--TNQIQRVVMSRALLR----
*. * : *. : .
Mflv_1793|M.gilvum_PYR-GCK ----
Mvan_4957|M.vanbaalenii_PYR-1 ----
MSMEG_5621|M.smegmatis_MC2_155 ----
TH_0680|M.thermoresistible__bu ----
MMAR_3982|M.marinum_M PVSA
MUL_3843|M.ulcerans_Agy99 PVSA
MAV_1628|M.avium_104 PVSA
Mb3574c|M.bovis_AF2122/97 ----
Rv3544c|M.tuberculosis_H37Rv ----
MAB_4159|M.abscessus_ATCC_1997 ----
MLBr_00737|M.leprae_Br4923 ----