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VAVVGMACRFPGGVDSPDGLWEMVSEGRDVVSELPLDRGWDLGRLYDPDPDRLGCVYTRGGGFLSGVADF DAGFFGISPREALGMDPQQRLMLEIAWETFESAGIDPHSLRGSQTGVFAGVMSSHYEEIGGDQAEGCLAV GTEASVVSGRVAFTFGLEGPAVSVDTACSSSLVAIHQAGQSLRGGECSMALAGGVMVMAVPSTLVEFSRK RGLSPDGRCRSFAAAADGTGFAEGAGLVLLERLSDARRHGHQVLAVIRGSAINQDGASKRLTAPNGRAQE RVIRSALTAAGLEVADVDVVEAHGTGTLKGDPIEAHAILATYGQDRPADRPLWLGSVKSNMGHTQAAAGV AGVIKMIQAMRHQVMPRSLHVDSPSPRVDWASGAVELLTEQRDWTVQDGRLRRAGVSSFGISGTNAHVIL EEAPAWSAPGHGGDSGAASPWPAVPWVVSGKSGQALAAQAGRLAGHLSADDDIDVLGVGWSLAQRSMFEH RAVVFGAGREELLSGLADLAQGRPAGAVLTGHAHVAGKTALVFPGQGAQWLGMGQQLHAQFPIFAAAFDA VAGELDQHLRMSLQSVLWGDNQALLNSTEFAQPALFAVEVAMLQLLRHWGIRPDFVLGHSVGEIAAAYAA QVLSLSDAALVVAARGRLMQSLPAGGVMFAVAATEDEVTPQLVDGAGIAAINAPGSVVISGTQEAVTPIV NDFHGRGRRVHQLAVSHAFHSPLVEPILDEFGSAISGITVGEPTISVVSNVTAALGGPEYGSPQYWVDHV RQPVRFADSVRLLESMGATRFVEVGPGAGLSTSVEQSLASPEDVVVIPVLGKQRPEGSSALHAAAVLFTT GATLDWSAVFDHTPAQRITLPTYAFQRRRFWLDGTSRAGDVGNVGLAAVAHALLGAVITQPDSGGVILTG LLTPRTQPWLADHRIAGVMLFPGAGFVELAIRAGDEVNCPVLHELTLMAPLAISESGVPVQVMVGAAGES GSRTVAVYSAEGQSDSEWILHAKGVLTVGTAEPSLMSSELSAWPPAGAEVLDIAGGYDRLAGLGYQYGPA FQGLTAVWKRGEDVFAEIAVSEDLDVAGMEIHPALLDAALHAWVLASDAEGAASRDEGVQLPFMWQQVSL HGVGATRLRVHLARTQSNVVDVQLCDTSGMLVFTGSLLTRPVSPEKIHAALSAAGTQDDSGLMELTWAPI TLPEGRAGRIVAWRDQSTVDPVSEADPAGGVQADVVVWEVPATHRDVVASVHEVTHQLLAVLQSWLTVDR AGVLVVLTRGAVGLVGERVSDLAGAAVWGMVRSAQNEHPGQVLLVDLDAAASIVDGQIVTDSDGSDMRGL DLAALTKSGETQLVVRSQQVYAARLSAMAPTLEVADGGGVKPSSMLDPSGTVLITGGTGMAGGWLARHVV DHYGVRHVLLASRSGDRAGGSAEIAAELAARGVQVEVVACDVADRDAVTALLARLPQQYPLTGVIHAAGV LDDAVITSLTPDRVDTVLRAKVDAAWNLHELTRDLGVSAFVLFSSIAGTVGAPGQGNYAAANAFLDALAF QRRADGLTATSLAWGLWERSSTMTGHLSSRDMTRMNRTGMVALTAEQAVEMFDAALVAGHPAVVAGRFDR RMLHNPSFNAGLPPLFNELIGSPRRRTIEAGSLASQSALTQRLHGLTPEQQREMLTELVCTQIAIALGHN NSSEINPDQAFQGLGFDSLTAVELRNRLKAATGLSLTPTLVFDYPTPRDVASYLEYQLGGSEPIDGGNDD YVRQVQELVMSIPAKRLAQANVVDLLQKLKTDISDQLDERESASNLADMSLDDLVDVALTKFAAQQG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3796 | - | - | 100% (1817) | type I modular polyketide synthase |
M. marinum M | MMAR_0101 | - | 0.0 | 58.28% (1764) | polyketide synthase PKS |
M. marinum M | MMAR_1762 | pks15/1 | 0.0 | 56.43% (1485) | polyketide synthase Pks15/1 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2971c | pks1 | 0.0 | 56.76% (1487) | polyketide synthase PKS1 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 38.31% (1433) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv2048c | pks12 | 0.0 | 57.50% (1360) | polyketide synthase pks12 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 56.22% (1478) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 37.45% (1434) | polyketide synthase |
M. avium 104 | MAV_3108 | - | 0.0 | 53.96% (1501) | erythronolide synthase, modules 3 and 4 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 38.08% (1434) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_2454 | - | 0.0 | 31.91% (1808) | PUTATIVE beta-ketoacyl synthase |
M. ulcerans Agy99 | MUL_2005 | pks15/1 | 0.0 | 56.03% (1485) | polyketide synthase Pks15/1 |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 0.0 | 38.21% (1476) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0405|M.gilvum_PYR-GCK ----------------------MGSAAHQGE-SAHRFAIVGYAGRFPG-A MAB_0939|M.abscessus_ATCC_1997 ----------------------MDSAENPIE-STPRFAIIGYAARFPG-A MSMEG_0408|M.smegmatis_MC2_155 ----------------------MVSAEHPIE-PTPSFAIIGYAARFPG-A Mvan_1003|M.vanbaalenii_PYR-1 --------MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYALRFPG-A Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGV TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVVTRRAGFV MAB_0939|M.abscessus_ATCC_1997 ADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVVTRRAGFV MSMEG_0408|M.smegmatis_MC2_155 ASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVVTRRAGFV Mvan_1003|M.vanbaalenii_PYR-1 ADADEFWDVLRGGRDAISEVPQDR-WDADEFFDADPEAAGKMVTRRAGFV Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv DSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFV TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANTN MAB_0939|M.abscessus_ATCC_1997 EDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAETN MSMEG_0408|M.smegmatis_MC2_155 DDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANSN Mvan_1003|M.vanbaalenii_PYR-1 EDVAGFDAPFFGVSAREAMFMDPQHRLLLETAWRAVEHSGTAPSALAGTR Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv DGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSA TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQG MAB_0939|M.abscessus_ATCC_1997 SGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQG MSMEG_0408|M.smegmatis_MC2_155 TGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQG Mvan_1003|M.vanbaalenii_PYR-1 TGVFMGLSTHDYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRISYRLGLQG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv TGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLEG TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPATMITFSN MAB_0939|M.abscessus_ATCC_1997 PSVAVDTACSSSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFSH MSMEG_0408|M.smegmatis_MC2_155 PAVAVDTACSSSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFSN Mvan_1003|M.vanbaalenii_PYR-1 PAVAVDTACSSSLVAVHQACQALRLAECDVALAGGVNVLLSPATMINFSR Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv PAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSR TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIRG MAB_0939|M.abscessus_ATCC_1997 AHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIRG MSMEG_0408|M.smegmatis_MC2_155 AHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIRG Mvan_1003|M.vanbaalenii_PYR-1 ARMLAPDGRCKTFDATADGYVRGEGCGVVVVKRLADAIRHGDRIRAVIRG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv HRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVG TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTSL MAB_0939|M.abscessus_ATCC_1997 SAINQDGASGGLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTSL MSMEG_0408|M.smegmatis_MC2_155 SAINQDGASGGLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTSL Mvan_1003|M.vanbaalenii_PYR-1 SAVNQDGASGGLTVPNGAAQQRVIADALTNAGLTAADVDYLEAHGTGTPL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv SAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTL TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GDPIEAQAAGAALGPGR-EPQRPLLIGSAKTNIGHLEAAAGIAGVIKVVL MAB_0939|M.abscessus_ATCC_1997 GDPIEAQAAGAAYGIGR-ETNDPLLIGSAKTNIGHLEAAAGIAGVIKVIL MSMEG_0408|M.smegmatis_MC2_155 GDPIEAQAAGEVLGAGR-APEEPLLIGSAKTNIGHLEAAAGIAGVIKVVM Mvan_1003|M.vanbaalenii_PYR-1 GDPIEVQAAGAVLGVGR-EPDRPLLIGSVKTNIGHLEAASGIAGLLKVIL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv GDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVL TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPRIAGV MAB_0939|M.abscessus_ATCC_1997 SLENELLPQHRNFQNPSPHIPWDRLPVEVVREARPWGR---NGRPRIAGV MSMEG_0408|M.smegmatis_MC2_155 ALENETLPKHLNFETPSPHIPWERLPIEVVRETVPWQR---NGKPRIAGV Mvan_1003|M.vanbaalenii_PYR-1 SLEHQVLPKHLNFRSPSPHIPWNRLPVRIVDDPVPWTR---SGRSRVAGI Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv AMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAG---ARTRRAGV TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SSFGFAGTNAHVILEEAPLAAEPAQES---VDDGRFTLLPLSARTPAALM MAB_0939|M.abscessus_ATCC_1997 SSFGFAGTNAHVILEEAPVVSRDAVEPPAPAGGRKFSILPLSARTPAALA MSMEG_0408|M.smegmatis_MC2_155 SSFGFAGTNAHVILEEAPAVGTPATTEP-VEDPRRYSVLPLSARTPEALV Mvan_1003|M.vanbaalenii_PYR-1 SSFGFSGTNAHVLVEEAPRADRAGAAPQ-PAAPGGFGMLPLSARTPDALA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv SSFGISGTNAHVIIEAVPVVPRREAGWA-----GPVVPWVVSAKSESALR TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AVADRYRDWLVANPDATLADLCFTAGTARSHLEHRAALVVNTREAALDLL MAB_0939|M.abscessus_ATCC_1997 QLADKYRAWLNAHPEAALADLCFTAGVGRAHLEHRAALVVNTREAAVELL MSMEG_0408|M.smegmatis_MC2_155 RLAGEYRDWLRAHPQARLADVSHTAGTARAHLEQRAALVVNSRESAIELL Mvan_1003|M.vanbaalenii_PYR-1 ATAHRLRTWLAANPDASWPDLCFTAAVGRSHLRHRAALVVDSRSSVEELL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv GQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGL TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GALADDRPAPGLVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTEPLFAE MAB_0939|M.abscessus_ATCC_1997 SAVADDRPAPGLGRGESHDTPKTAWLFTGQGSQYPGMARELFETEPVFAD MSMEG_0408|M.smegmatis_MC2_155 GALADDRPAPGLVRGESHEAPKTAWLFTGQGSQYPGMARELFDTEPVFAE Mvan_1003|M.vanbaalenii_PYR-1 GALAEDRPGPGLARGECGDPPKTAWLFTGQGSQYPGMGRELFDTEPVYRE Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQ TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TLRECAAAVDGMLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPALFAVE MAB_0939|M.abscessus_ATCC_1997 TLNRCAAAVADVLEKPLLDVIFDVD---GPEAEETLRQTSYAQPALFAVE MSMEG_0408|M.smegmatis_MC2_155 TVRKCAEAVADILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPALFAVE Mvan_1003|M.vanbaalenii_PYR-1 VMTRCAEAVADVLERPLLDVVFDAD------GGEALRHTSYAQPALYAVE Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv QIDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPVLFAVM TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK MGLARLWQSWGFEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAERGRLF MAB_0939|M.abscessus_ATCC_1997 MGLARLWQSWGFEPDVVLGHSVGQYSAACVAEVFSLEDGARLIAERGRLF MSMEG_0408|M.smegmatis_MC2_155 LGLARLWQSWGFEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAERGRLF Mvan_1003|M.vanbaalenii_PYR-1 MGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVMGLEDGAVLLAERGRLF Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLL TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GSLPSGGRMAAVFAAAERVEALTDEYPALS--VAAYNGANTVLSGPATDL MAB_0939|M.abscessus_ATCC_1997 SSLPAGGRMAAVFTDAERAERLTDEFPSLS--VAAYNGANTVLSGPAQDL MSMEG_0408|M.smegmatis_MC2_155 GSLPAGGRMAAVFTAPERAERLTDEYPSLS--VAAYNGANTVLSGPAKDL Mvan_1003|M.vanbaalenii_PYR-1 GSLPEGGRMAAVFAPADRVESCTVDSPLLS--VAAYNGDNTVLSGPAGDL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv AGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSGEVGAL TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ERAVAGLVADGVRCDWLETSHAFHSALLDPILDDFESYARGITFTAPQRI MAB_0939|M.abscessus_ATCC_1997 EKAIAALVADGVRCDFLETSHAFHSALLDPILDEFEAYANQFNYKTPQRI MSMEG_0408|M.smegmatis_MC2_155 ESAVATLVADGVRCDWLDTSHAFHSALLDPILDDFESFAQKLEYREPQRI Mvan_1003|M.vanbaalenii_PYR-1 ERAVAGFSAAGVRCDWLDTSHAFHSALLDPVLEEFESCADRFEFGTPQRT Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv EELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTV TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LIDNRTGAALGRSVTLDAAYWRRHARQPVEFAKSVHTLADMNCKLLVEIG MAB_0939|M.abscessus_ATCC_1997 LIDNRTGTALGRSVKLDGAYWRRHARQPVEFAKSVRTLADMNCKVLLEIG MSMEG_0408|M.smegmatis_MC2_155 LIDNRTGSALGRSTRLDGAYWRRHARQPVEFAKSVRTLADMNCRVLLEIG Mvan_1003|M.vanbaalenii_PYR-1 LVCNRSGEVLSRHARLDGQYWRRHARQPVRFAESVRTLADLGCRLLMEIG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv FFSTVTGNRL-DTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESS TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PRPVLTAAALSAWP---DPATSPRVIASLRRTTADQRQITEAVADAYVLG MAB_0939|M.abscessus_ATCC_1997 PQPVLTAAALRAWP---DPATAPRAIASLRRNTADHRQITEAAADAYVLG MSMEG_0408|M.smegmatis_MC2_155 PRPVLTATALAAWP---DPATTPQVLASLRPTTADHRQITEAVAAAYAAG Mvan_1003|M.vanbaalenii_PYR-1 PQPVLTAAAMRTWP---GTVTAPRVAASMRRKGSDRRQITEALAQAYVAG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv PHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAG TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK HLPRFAAFRRDGARVLDLPTYPFEHRQYWFSDSRE---PVAAAPQR---G MAB_0939|M.abscessus_ATCC_1997 HLPDFGAFQHAPARKLDLPTYPFERRQYWFSDKRDGDNRDAGNRQQNNGG MSMEG_0408|M.smegmatis_MC2_155 HLPDFRAFRQPDARKLDLPTYPFEHRQFWFSDNRAIDRDTQTASAGSVTP Mvan_1003|M.vanbaalenii_PYR-1 HRPETAARQHGRGRLLDLPTYPFQHRAYWFP--------QGQARTAPTDP Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VAVNWRGTLDG-AGYVELPTYAFDKRRFWLSAEGSGADVSGLGLGASEHP TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ARTETVRLLEDG-------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PRTEAVRLLEDG-------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 HRTQAVRLLEDG-------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 VHTETVRFLDEE-------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGFVELAIR TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv AGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSRGVSIFSRA TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv DAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRGY TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -----------------------RIEELAALLGGTVDDPFTFDVLNRLAA MAB_0939|M.abscessus_ATCC_1997 -----------------------KIEELANLLGGVDGDQQTLNVLTKLAA MSMEG_0408|M.smegmatis_MC2_155 -----------------------QIEELAALIDGETVDEQTLRVLNKLAA Mvan_1003|M.vanbaalenii_PYR-1 -----------------------RIDELAALLDGPTGSAQTVDVLSKLAA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv RYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVV TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QHNQQRSTESIADDRYQIRWETAAEPPVGADAADGITWLLVGDDTDATRP MAB_0939|M.abscessus_ATCC_1997 QHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVADAAGAAQP MSMEG_0408|M.smegmatis_MC2_155 RHNQQRSTHVDPDARYEIRWDAIASAAASTGAAA--DWILVGDDTAAVLE Mvan_1003|M.vanbaalenii_PYR-1 RHRQQRGAQSIADARYQIRWEKSEAPGAARPTTEATTWLLVTHDSRAAQP Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv IAGDPDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLP TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAADATDLRIVHVAALD MAB_0939|M.abscessus_ATCC_1997 LLDVLTARGQQHRVLALPVSDADEAELVEALRSAADEDSALRIVHVAALA MSMEG_0408|M.smegmatis_MC2_155 FADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAG--ELYVVHIAAGD Mvan_1003|M.vanbaalenii_PYR-1 IAEVLERRGHPYHIVGLPGSDADAAPAEEALRATVSQ-PRPHILYLAALE Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VLSVASMVARPVTERQLLAAVSGSGPDRLFEVIWSPASAATSPGPTPAYQ TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AAESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQLRSPMWLVTRGAQHVTD MAB_0939|M.abscessus_ATCC_1997 GQGS-SSAQSLLRIQHQVLGGTRRLFRAAAAAELRAPIWIVTRGAQHVIE MSMEG_0408|M.smegmatis_MC2_155 GAAA--PMRDLLRVQHRTLGGLRRLFRAANDAELRSPIWLVTRDGQRVTD Mvan_1003|M.vanbaalenii_PYR-1 EPGG-SAAETLGWMQHRVLAAARRLFQLAATAGARAPIWLITAGAQRITG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv IFESVAADQDPVAGSYVRSHQALAAVQSWLTDHESGVLVVATRGAMALPR TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TDVVAPDQTCLWGFGRAASLEHPQIWG----------------------- MAB_0939|M.abscessus_ATCC_1997 GDTVAPEQSALWGFGRAAALELPQVWG----------------------- MSMEG_0408|M.smegmatis_MC2_155 TDTVVPEQSCLWGFGRAAALELPHIWG----------------------- Mvan_1003|M.vanbaalenii_PYR-1 DETVEPAQTSLWGFGRAAALEQPELWG----------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv EDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQ TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ------------------------------GLADLGGGTSDEWSRLLNRI MAB_0939|M.abscessus_ATCC_1997 ------------------------------GLADLSDAGTDEWAQFIGRV MSMEG_0408|M.smegmatis_MC2_155 ------------------------------GLADLSGADT-EWPRLIARI Mvan_1003|M.vanbaalenii_PYR-1 ------------------------------GLADVTTGDAEEWSALIDHI Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVP TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AATHDPAVMEDQVAVRGSTSYVPRLVHRDTLPSGKPLHLRADATYLVTGG MAB_0939|M.abscessus_ATCC_1997 SVSGEASTREDQLALRGQAVHVPRLVRREELPSGKPLEVRSDATYLVTGG MSMEG_0408|M.smegmatis_MC2_155 TSPRDG---EDQIALRGDAVYAPRLVRRTGEPSDTPLPVREDRTYLVTGG Mvan_1003|M.vanbaalenii_PYR-1 VAAPTS---EDQIAVRGREIHVARLTRCAEKANAAALELRREATYLVTGG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv NADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVG TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LGSLGLEIAG---------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LGSIGLEIAG---------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 LGAIGLEVAG---------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 LGALGLEVAE---------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv PGVTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVF TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv TTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDA TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv SLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQY TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv MLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGSW TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ---------------------YLAANGAGHLVLTSRRTPDEAAASRIEAL MAB_0939|M.abscessus_ATCC_1997 ---------------------YLAGRGAKHLVLTSRREPGEAARQRIDAL MSMEG_0408|M.smegmatis_MC2_155 ---------------------YLASHGAGHVVLTSRREPGDDARRRLDGL Mvan_1003|M.vanbaalenii_PYR-1 ---------------------FLASHGAGHLVLTGRRSASDTVRQRIDAM Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv AAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAE TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RERHGCEVRVVTADVADAHAVARLLATVQAEMPPLAGIVHAAGEIGTTPL MAB_0939|M.abscessus_ATCC_1997 AA-QGCEVRAVTADVADGHDVARLLAGIQAELPPLAGIVHAAGEIGTTPL MSMEG_0408|M.smegmatis_MC2_155 REQYACDVRVITADVADAHDVARLMTTVAAELPPLAGIVHAAGEIGTTPL Mvan_1003|M.vanbaalenii_PYR-1 RERFDCQVLVATADVADRDDVARLFSTMRSELPPLAGIVHAAGEIGTSPL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LAAAGAQVQVVACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVV TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ADLDDAEVDRVFAGKVWGAWHLSEATSDLQ--LDFFISTSSIASVWGGFG MAB_0939|M.abscessus_ATCC_1997 SDLEDAEVDRVFAGKVWGAWHLSEAAAGLK--LDFFINTSSIAAVWGGYG MSMEG_0408|M.smegmatis_MC2_155 SGLDDAEVDRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSSIASVWGGFG Mvan_1003|M.vanbaalenii_PYR-1 RTLDDAEMDRVFAGKVWGAVYLCEEVADMG--LDFFLATSSIASVWGSHG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv MSLTPDRVDVVLRSKVDAAWHLHELTRDLD--VSAFVMFSSMAGLVGSSG TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QAAYGAANAFLDGLAWRLREQGVAGVSVNFGPWSAG-----MADAQSRAR MAB_0939|M.abscessus_ATCC_1997 QTAYSAANAFLDGLAWRLREQGIAGTSVNFGPWSAG-----MADAESRAR MSMEG_0408|M.smegmatis_MC2_155 QTAYGAANAFLDGLAWRLRERGVTAVSVNFGPWAAG-----MADAESRAR Mvan_1003|M.vanbaalenii_PYR-1 QTAYGAANAFLDGLADSLRARGIPGISVNFGPWAAG-----MADAKAREQ Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv QANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLAR TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LEQRGIKTLSPADALAGLSDAVISAAP---HPVVARVDWSRFLPLYQQAG MAB_0939|M.abscessus_ATCC_1997 LEQRGIKTLSPTDALAGLADVVAASGSNAVQGVIARIDWARFLPLYQQAG MSMEG_0408|M.smegmatis_MC2_155 LEQRGVRTLSPAEALAGMADVVAGPVQ----GVVAKIDWSRFLPLYQQAG Mvan_1003|M.vanbaalenii_PYR-1 LSRRGVKTLAPADALAGMADVIAASTA---HAVVARIDWATFLPVYQLQR Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LGREGVLALSTAEALELFDTAMIVDEP-----FLAPARIDLTALRAHAVA TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RRGFLAELERELPAAPAQQGPAVTASGRTPLVERLTTAPLQQRKRLLTDY MAB_0939|M.abscessus_ATCC_1997 KRGFLAELDREVPSHLA--GVAGAQSGSTQLVERLANAPVQQRKKLLTDY MSMEG_0408|M.smegmatis_MC2_155 RRAFLSELESELPAAATGAAAPATVPGKPPLVEQLTKAPVQQRKSLITNY Mvan_1003|M.vanbaalenii_PYR-1 RRAFLSQLEREVPDVPD--ASAPAPSGTTRFVEELTLAPVEQRRKLVLEY Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLV TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LRDAVAEVTRVDAAEIREDAGFFDLGMDSLMAVELRRRIETGVGKEIPVT MAB_0939|M.abscessus_ATCC_1997 LRDAVAEVTRVDVSEIREDAGFFDLGMDSLMAVELRRRMEQGVGKEIPVT MSMEG_0408|M.smegmatis_MC2_155 LRNAVAEVTRVDADEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKDIPVT Mvan_1003|M.vanbaalenii_PYR-1 LRAAVAEVTRVDAAEIRDEAGFFDLGMDSLMAIELRRRLEQGLGKELPVT Mb2971c|M.bovis_AF2122/97 -----------------------------------------MIEEQRTMS MLBr_00135|M.leprae_Br4923 ----------------------------------------------MTAS MUL_2005|M.ulcerans_Agy99 ----------------------------------------------MTTS MAV_3108|M.avium_104 -------------------------------------------------- MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv RLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPT TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LVMDHPRLSDAADYLLGDVLGLTEAAT-APKAATVVSTAADEPIAIVAVS MAB_0939|M.abscessus_ATCC_1997 LVMDHPRISDVADYLLGDVLGLAEQAKPAAQLASAVTGRTDEPIAIVAVS MSMEG_0408|M.smegmatis_MC2_155 LVMDHPRLSDAADYLLVEVLGLGEQTN--VRQASTVTARTDDPIAVVAVS Mvan_1003|M.vanbaalenii_PYR-1 LAMDHPHLSDAAEYVLGDVLGLSEHTV--AQPDTPSTVRTDDPIAIVGMA Mb2971c|M.bovis_AF2122/97 VEGADQQSEKLFHYLKKVAVELDETRA----RLREYEQRATEPVAVVGIG MLBr_00135|M.leprae_Br4923 VEGADQKSEKLISYLKKVVVELDETRA----RLREYEQRATEPVAVVGIG MUL_2005|M.ulcerans_Agy99 GESADQQNDKLFRYLKKVAVELDEARA----RLREYEQRATEPVAVVGIG MAV_3108|M.avium_104 ----MPGTEQHLDYLKRLTADLRRTRR----RVAELEGRLSEPVAVVGMA MMAR_3796|M.marinum_M -------------------------------------------MAVVGMA Rv2048c|M.tuberculosis_H37Rv LIFDYPTPNRLASYIRTELAGLPQEIK----HTPAVRTTSEDPIAIVGMA TH_2454|M.thermoresistible__bu -----------------------------MSVDVTAKARPDDPIAIIGIG :*::.:. Mflv_0405|M.gilvum_PYR-GCK CRFPG-APNPEAFWDLLSGGVDAIREVPEDR-FDIDEFYDPDPDAAGKTY MAB_0939|M.abscessus_ATCC_1997 CRFPG-APDPEAFWDVLSGGVDAIREVPEDR-FDIDEFYDPDPEVAGKTY MSMEG_0408|M.smegmatis_MC2_155 CRFPG-APDPESFWELLAGGVDAIREVPEDR-WDIDEFYDPDPDTPGKTY Mvan_1003|M.vanbaalenii_PYR-1 CRFPG-ADDTDAFWSVLAEGADLIREIPDDR-FDINEFYDPDPEAAGKIY Mb2971c|M.bovis_AF2122/97 CRFPGGVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAEGKTY MLBr_00135|M.leprae_Br4923 CRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTY MUL_2005|M.ulcerans_Agy99 CRFPGGADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAEGKTY MAV_3108|M.avium_104 CRYAGGVDSPEALWDLVIEGRDTVSDFPVDRGWDVEGLYDPDPDAKGKMY MMAR_3796|M.marinum_M CRFPGGVDSPDGLWEMVSEGRDVVSELPLDRGWDLGRLYDPDPDRLGCVY Rv2048c|M.tuberculosis_H37Rv CRYPGGVNSPDDMWDMLIQGRDVLSEFPADRGWDLAGLYNPDPDAAGACY TH_2454|M.thermoresistible__bu CRLAGRITSPEEFWGFLLAGGSNVREIPAER-WEPYLRRDPRNAAVLREI ** .* ..: :* .: . : :.* :* :: :* Mflv_0405|M.gilvum_PYR-GCK TRYGGFLDHIDEFDPEFFGLSPREAVWIEPQQRLMLETVWEGLERAGYAP MAB_0939|M.abscessus_ATCC_1997 TRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYSP MSMEG_0408|M.smegmatis_MC2_155 TRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYAP Mvan_1003|M.vanbaalenii_PYR-1 SRYGGFLDGVDGFDPEFFGISPREAVWIDPQQRLVLETAWEGLERAGYSA Mb2971c|M.bovis_AF2122/97 TRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHAGIDP MLBr_00135|M.leprae_Br4923 TRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDP MUL_2005|M.ulcerans_Agy99 TRWGAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHAGIDP MAV_3108|M.avium_104 TRQGSFLQHAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERAGIDP MMAR_3796|M.marinum_M TRGGGFLSGVADFDAGFFGISPREALGMDPQQRLMLEIAWETFESAGIDP Rv2048c|M.tuberculosis_H37Rv TRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWEALERAGIDP TH_2454|M.thermoresistible__bu TPWGTFLDDLAGFDAEFFGVSPREAELTDPQQRLALEVSWEALEHAGVPP : * *:. **. ***: * *. :**:*: ** ** :* ** . Mflv_0405|M.gilvum_PYR-GCK SALRGSRTGVFVGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAF MAB_0939|M.abscessus_ATCC_1997 AALRGSRTGIFAGVGANEYAHLLSSESIDKIEPYFITGNALNAISGRVAF MSMEG_0408|M.smegmatis_MC2_155 SDLRGSRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAF Mvan_1003|M.vanbaalenii_PYR-1 AALRGSRSGVYVGVGANEYSHLLSGGSLDGIEAQFITGNALNVIAGRVSF Mb2971c|M.bovis_AF2122/97 LSLRGSATGVYTGIFAASYGNRDT----GGLQGYGLTGTSISVASGRVSY MLBr_00135|M.leprae_Br4923 LSLRGSATGVFTGIFAPSYGSRDT----GGLQGYGLTGTAVSVASGRVSY MUL_2005|M.ulcerans_Agy99 MSLRGSSTGVFTGIFAPSYGGKDV----GALQGYGLTGSPVSVASGRVAY MAV_3108|M.avium_104 SALRGTATGVFAGVIHAGYGGEVK----GELEGYGLTGSTLSVTSGRVSY MMAR_3796|M.marinum_M HSLRGSQTGVFAGVMSSHYEEIGG----DQAEGCLAVGTEASVVSGRVAF Rv2048c|M.tuberculosis_H37Rv TGLRGSATGVFAGVMTQGYGMFAA----EPVEGFRLTGQLSSVASGRVAY TH_2454|M.thermoresistible__bu RSLAGTDTAVLMGVNSDDYGRLLMED-LPGIEAWTGIGTSLCGIANRVSH * *: :.: *: * : * :.**:. Mflv_0405|M.gilvum_PYR-GCK ALGLEGPAVAVDTACSSSLVAVHQATQALRSGDCDMALAGGVNVLLSPVT MAB_0939|M.abscessus_ATCC_1997 ALGFEGPAVAVDTACSSALVAVHQAVQALHSGDCDLALAGGVNVLLSPVT MSMEG_0408|M.smegmatis_MC2_155 ALGFEGPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLLSPVT Mvan_1003|M.vanbaalenii_PYR-1 TLGLEGPAVAVDTACSSSLVAVHQACQGLQSGDCDLALAGGVNVLLSPAT Mb2971c|M.bovis_AF2122/97 VLGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSI MLBr_00135|M.leprae_Br4923 VLGLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSI MUL_2005|M.ulcerans_Agy99 VLGLEGPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMGLPSI MAV_3108|M.avium_104 VLGLEGPAVSVDTACSSSLVAMHLAAQSLRSGECDLALAGGVTVMATPAA MMAR_3796|M.marinum_M TFGLEGPAVSVDTACSSSLVAIHQAGQSLRGGECSMALAGGVMVMAVPST Rv2048c|M.tuberculosis_H37Rv VLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDI TH_2454|M.thermoresistible__bu LLDLRGPSVALDAACAASLVAVHNACQLLRAGETGLAIAGGVSALIGPGL :.:.**::::*:**:::***:* * *:.*: .:*:**** . * Mflv_0405|M.gilvum_PYR-GCK VVAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAVRDGDRV MAB_0939|M.abscessus_ATCC_1997 VIAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAERDGDRV MSMEG_0408|M.smegmatis_MC2_155 VVAASRARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRV Mvan_1003|M.vanbaalenii_PYR-1 TIATSRARMLSPDGRCKTFDAAADGYVRGEGCGILVLKRLSDAVRDGDRI Mb2971c|M.bovis_AF2122/97 FVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRLGHSV MLBr_00135|M.leprae_Br4923 FVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGHTV MUL_2005|M.ulcerans_Agy99 FVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRNGHNV MAV_3108|M.avium_104 FVEFSRQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPV MMAR_3796|M.marinum_M LVEFSRKRGLSPDGRCRSFAAAADGTGFAEGAGLVLLERLSDARRHGHQV Rv2048c|M.tuberculosis_H37Rv FVEFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPV TH_2454|M.thermoresistible__bu TRVLDKAGATAPDGRCKSFDASADGYGRGEGAAVVILKRLPDALRDGDRV .: :. ***: : :*** .** .:::*:**.** * *. : Mflv_0405|M.gilvum_PYR-GCK CAVIAGSAVNQDGASSGLTVPNGGAQQRLIGTVLARAGITGGEVDYLEAH MAB_0939|M.abscessus_ATCC_1997 LAVIPGSAVNQDGASSGLTVPNGGAQQRLIGSVLARAGLVGGDVDYLEAH MSMEG_0408|M.smegmatis_MC2_155 CAVIPASSVNQDGASSGLTVPNGGAQQRLIEATLARAGLSGADVDYLEAH Mvan_1003|M.vanbaalenii_PYR-1 QAVIRGSAVNQDGASGGLTVPNGGAQQRVIAAALTRAGLSGSDIDYLEAH Mb2971c|M.bovis_AF2122/97 LAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALANAGLSAADVDVVEAH MLBr_00135|M.leprae_Br4923 LAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVEAH MUL_2005|M.ulcerans_Agy99 LAVVRGSAINQDGASNGLTAPNGLTQQRVIQAALANCGLTSADVDVVEAH MAV_3108|M.avium_104 WAVLRGSAVNQDGASNGLTAPNGPSQQRVIRAALANAGLSAVDVDVVEGH MMAR_3796|M.marinum_M LAVIRGSAINQDGASKRLTAPNGRAQERVIRSALTAAGLEVADVDVVEAH Rv2048c|M.tuberculosis_H37Rv LAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGH TH_2454|M.thermoresistible__bu IAVIRGGAVAQDGRTVGIMSPNGAAQRDLFRHTCEITGTSPATVDFVEAH **: ..:: *** : : *** :*. :. . * :* :*.* Mflv_0405|M.gilvum_PYR-GCK GTGTPLGDPIEVQAAAAAYAGAR-DADRPLLMGSVKTNIGHTESASGAAG MAB_0939|M.abscessus_ATCC_1997 GTGTPLGDPIEVQAAAAAYGGSR-DADRPLLMGSVKSNIGHTESASGAAG MSMEG_0408|M.smegmatis_MC2_155 GTGTPLGDPIEVQAAAAAYGAGR-DADRPLLMGSVKTNIGHTESASGAAG Mvan_1003|M.vanbaalenii_PYR-1 GTGTSLGDPIEVQAAGAVLGAGR-DPDRPLLMGSVKTNVGHLESASGVAG Mb2971c|M.bovis_AF2122/97 GTATTLGDPIEAQALLSTYGQGR-PAEQPLWVGSIKSNMGHTQAAAGVAG MLBr_00135|M.leprae_Br4923 GTATTLGDPIEAQALLATYGQGR-PADQPLWVGSIKSNMGHTQAAAGVAG MUL_2005|M.ulcerans_Agy99 GTATTLGDPIEAEALLATYGQGR-PTDQPLWVGSIKSNMGHTQAAAGVAG MAV_3108|M.avium_104 GTGTVLGDPIEAQALLATYGQDR-PADRPLWLGSIKSNIGHTSAAAGVAG MMAR_3796|M.marinum_M GTGTLKGDPIEAHAILATYGQDR-PADRPLWLGSVKSNMGHTQAAAGVAG Rv2048c|M.tuberculosis_H37Rv GTGTTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAG TH_2454|M.thermoresistible__bu GTGTPTGDPVELDALAAVYGAAH-GPDDPCRVGSVKPNTGHLEGGAGVVG **.* ***:* .* :. . : . * :**:*.* ** ...:*..* Mflv_0405|M.gilvum_PYR-GCK LIKVVLSLQHETLPQSLHFDTPSPHIPWDSLPVRVVDTAMPWQPN-GRPR MAB_0939|M.abscessus_ATCC_1997 LIKVVLSLQNGVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQAN-GRPR MSMEG_0408|M.smegmatis_MC2_155 LIKVVLSLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQTN-GRVR Mvan_1003|M.vanbaalenii_PYR-1 LIKVVLSLQHEMLPRHLHFKTPSPHIPWDRLAVRVVAEPTPWRAD-GRPR Mb2971c|M.bovis_AF2122/97 VIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWSVD-GRPR MLBr_00135|M.leprae_Br4923 VIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSVE-GRPR MUL_2005|M.ulcerans_Agy99 VIKMVQAMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWPDA-GRPR MAV_3108|M.avium_104 VIKMVQALRHGVMPKTMHVDVPSPHVDWSAGAVSLLTDPRPWPEH-GGPR MMAR_3796|M.marinum_M VIKMIQAMRHQVMPRSLHVDSPSPRVDWASGAVELLTEQRDWTVQDGRLR Rv2048c|M.tuberculosis_H37Rv VIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAG-ARTR TH_2454|M.thermoresistible__bu LIKAALALQHGVIPPTAGIRELTPAVDWATNGLHVPTTVEPFPRRADSPR :** :::: :* . : : * : : : * Mflv_0405|M.gilvum_PYR-GCK RAGVSSFGFTGTNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAP MAB_0939|M.abscessus_ATCC_1997 RAGVSSFGFTGTNAHVLIEEAPQPQATP----------DEDDASTPQSAP MSMEG_0408|M.smegmatis_MC2_155 RAGVSSFGFTGTNAHVLVEEAPPQLHTADAAP----VEPAATAEAGTDDS Mvan_1003|M.vanbaalenii_PYR-1 RAGVSSFGFSGTNAHVVLEEPPAQSADLRQPPTDGKDGAAGLESATAPEP Mb2971c|M.bovis_AF2122/97 RAAVSSFGISGTNAHLILEEAPVPAPAE------APVEASESTGGP-RPS MLBr_00135|M.leprae_Br4923 RAGVSSFGISGTNAHVILEEAPT------------PVEASYSTADQQRLS MUL_2005|M.ulcerans_Agy99 RAGVSSFGISGTNAHVILEEAPAP----------EAVPDSESNKGEPSLP MAV_3108|M.avium_104 RAGVSSFGISGTNAHVIVEQAPAA-----------AETEAAPASSTMPDA MMAR_3796|M.marinum_M RAGVSSFGISGTNAHVILEEAPAW----------SAPGHGGDSGAASPWP Rv2048c|M.tuberculosis_H37Rv RAGVSSFGISGTNAHVIIEAVPVV----------PRR----EAGWAG--P TH_2454|M.thermoresistible__bu RAAVCSYGYGGTIAHLLLEEAPAVDETP-----AAAPAPAADAADANSPR **.*.*:* ** **:::* * Mflv_0405|M.gilvum_PYR-GCK VEVLPLSARSPEALVALAQRYETWLTAHPEADLADVCRTAGTGRSHFEHR MAB_0939|M.abscessus_ATCC_1997 VSVLPLSARSPEALAAVAQRYESWLAAHPDVDLEDVCLTAGRGRSHFEHR MSMEG_0408|M.smegmatis_MC2_155 PQVLALSARSPEALVELARRYDDWLSATPGLDIADVCHTAGVGRSHFEYR Mvan_1003|M.vanbaalenii_PYR-1 AGVLPISARSPEALTALARRYESWLTAHPDADIADVCYTAGAGRSHFEHR Mb2971c|M.bovis_AF2122/97 MVPWVISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLAS-RSVFEHR MLBr_00135|M.leprae_Br4923 VVPWVVSGRSTAALMAQASRLAFYVQADPEVDPVDVGCALAA-RSVFEHR MUL_2005|M.ulcerans_Agy99 VVPWVISARSAEALTAQAGRLLAHVQADPQSNPVDIGFSLAG-RSAFEHR MAV_3108|M.avium_104 VVPWVVSARSAEALAGQARRLLDHVTADAQASPLDVGWSLVSTRAVFEHR MMAR_3796|M.marinum_M AVPWVVSGKSGQALAAQAGRLAGHLSADDDIDVLGVGWSLAQ-RSMFEHR Rv2048c|M.tuberculosis_H37Rv VVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHR TH_2454|M.thermoresistible__bu FHVIPVSARSGARLARHAAALRGHLSAG--ADLTAVAATMWQRRSHEPVR :*.:* * * : . . : : *: * Mflv_0405|M.gilvum_PYR-GCK AALVVDSVESARIALTDLAQNRLRPGVVRGEHLNHPTT--AWMFTGQGSQ MAB_0939|M.abscessus_ATCC_1997 AALVVDSIQTAREGLLELAQNRLRPGVVRGEHTNHPTT--AWLFTGQGSQ MSMEG_0408|M.smegmatis_MC2_155 AALVVDSVERAREGLAALAEGRTPAGVVRGEHVHRPTT--AWLFTGQGSQ Mvan_1003|M.vanbaalenii_PYR-1 AALVVDSVDGARDLLAGLAEDRLGPGAVRGVCGDPPKT--AWLFTGQGSQ Mb2971c|M.bovis_AF2122/97 AVVVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKT--VVVFPGQGAQ MLBr_00135|M.leprae_Br4923 AVVVGESREQLIAGLAGLAVGESGAGVAIGQAAPLGKT--VVVFPGQGAQ MUL_2005|M.ulcerans_Agy99 AVVVGADRQQLLTGLATLADGAPGAGVVTGQAGSVGKT--AVVFPGQGSQ MAV_3108|M.avium_104 AVVVGRERGALATGLAGLASGRPGPATVVGRARSTGKT--VLVFPGQGSQ MMAR_3796|M.marinum_M AVVFGAGREELLSGLADLAQGRPAGAVLTGHAHVAGKT--ALVFPGQGAQ Rv2048c|M.tuberculosis_H37Rv AVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKT--VFVFPGQGSQ TH_2454|M.thermoresistible__bu AAVIARHPGELVAGLDAIATDTRHPAVVAGSVLPAAEAGAVWVFSGHGSH *.:. * :* . .. * : . :*.*:*:: Mflv_0405|M.gilvum_PYR-GCK YPGMARELFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVPPT MAB_0939|M.abscessus_ATCC_1997 YPGMARELFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGKAG MSMEG_0408|M.smegmatis_MC2_155 YPGMARELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRET----A Mvan_1003|M.vanbaalenii_PYR-1 YPGMARELFDTEPVFRDTVTRCAEAIGDTLPRPLLEVLFDTDGDN----G Mb2971c|M.bovis_AF2122/97 RIGMGRELYGELPVFAQAFDAVADELDRHLRLPLRDVIWGA-------DA MLBr_00135|M.leprae_Br4923 RIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGA-------DA MUL_2005|M.ulcerans_Agy99 RIGMARELHDQLPVFAEAFDAVADELDRHLRIPLCEVMWGS-------DV MAV_3108|M.avium_104 TLGMGRQLYERFEVFAGALDEAVAVVDEHSRLSVREVMWGA-------DP MMAR_3796|M.marinum_M WLGMGQQLHAQFPIFAAAFDAVAGELDQHLRMSLQSVLWGD-------NQ Rv2048c|M.tuberculosis_H37Rv WLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGH-------DE TH_2454|M.thermoresistible__bu WPGMGRELLEHEPVFAAVIDEIEPVFRAELGFSPRQALQSG--------- **. * :* . . . ..: Mflv_0405|M.gilvum_PYR-GCK ETLRHTSFAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVAGV MAB_0939|M.abscessus_ATCC_1997 EALRHTSFAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGV MSMEG_0408|M.smegmatis_MC2_155 DLLQHTSFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGV Mvan_1003|M.vanbaalenii_PYR-1 QTLRHTSYAQPALFAIEMGLARLWQARGIEPDVVLGHSVGQYAAACVAGV Mb2971c|M.bovis_AF2122/97 DLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAAGV MLBr_00135|M.leprae_Br4923 GLLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGV MUL_2005|M.ulcerans_Agy99 ALLDSTEFAQAALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVAGV MAV_3108|M.avium_104 ELLQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAACVAGV MMAR_3796|M.marinum_M ALLNSTEFAQPALFAVEVAMLQLLRHWGIRPDFVLGHSVGEIAAAYAAQV Rv2048c|M.tuberculosis_H37Rv NLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGV TH_2454|M.thermoresistible__bu -ELGGTDRVQALTFAVQAGLAAVLRDRGVKPAAVIGHSVGEVAACVAAGV * *. .*. *..: . .: * *:***:*: :*. .* * Mflv_0405|M.gilvum_PYR-GCK FSLEDGARLMAERGRLFGSLPEGGRMVAVFADAKRVEQVAADFPRVSVGA MAB_0939|M.abscessus_ATCC_1997 FSIEDGARLIAERGRLFGGLPAGGRMVAVFSDAKHVEQIAGEFPRVSVGA MSMEG_0408|M.smegmatis_MC2_155 FSLDDGARLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEFPRVSVGA Mvan_1003|M.vanbaalenii_PYR-1 FGLEDGARLVADRGRLFGGLPVGGRMVAVFTDAEVVEDFADEFPQVSVAA Mb2971c|M.bovis_AF2122/97 LTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEG--VGIAA MLBr_00135|M.leprae_Br4923 LAPADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEG--VGIAA MUL_2005|M.ulcerans_Agy99 LTLVDAAMLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDG--VGIAA MAV_3108|M.avium_104 LSLRDAARLVAARGALMAALPPGGVMVAVTAGESQVGPLLGGG--VSIAA MMAR_3796|M.marinum_M LSLSDAALVVAARGRLMQSLPAGGVMFAVAATEDEVTPQLVDG--AGIAA Rv2048c|M.tuberculosis_H37Rv LSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAE--VDIAA TH_2454|M.thermoresistible__bu FDLARGAAVACYRARGFRSVAGKGAMALVGLPFEDARQRLGERTDVVAAI : .* : *. : .:. * * * . . . . Mflv_0405|M.gilvum_PYR-GCK YNGP-NTVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLDE MAB_0939|M.abscessus_ATCC_1997 YNGP-NTVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILDE MSMEG_0408|M.smegmatis_MC2_155 YNGP-NTVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDE Mvan_1003|M.vanbaalenii_PYR-1 YNGP-NTVLAGPASDLEQIVAGCSGEGIRTTWLDTSHAFHSALLDPVLDE Mb2971c|M.bovis_AF2122/97 INAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEE MLBr_00135|M.leprae_Br4923 INAPESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEE MUL_2005|M.ulcerans_Agy99 INAPKSVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPMLEE MAV_3108|M.avium_104 VNGPDAVVLSGEQEAVAAVADRLAGSGARVHRLAVSHAFHSALMEPMLDG MMAR_3796|M.marinum_M INAPGSVVISGTQEAVTPIVNDFHGRGRRVHQLAVSHAFHSPLVEPILDE Rv2048c|M.tuberculosis_H37Rv VNGPASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDE TH_2454|M.thermoresistible__bu SASPLSTVISGTVDAVGEVSAAWAEQGVMVRKVNTDVAFHSPAMDALTAE .* *::* * : .. **** ::.: Mflv_0405|M.gilvum_PYR-GCK FESYAAQLQFAAPTLPLVCNRTGAVLTGQT-SLDAQYWRRHSRQPVQFAE MAB_0939|M.abscessus_ATCC_1997 FESYAAQVQFAAPTLPLVCNRTGAVLTAQT-PIDGQYWRRHSRQPVQFAE MSMEG_0408|M.smegmatis_MC2_155 FEAYAAQFQFAAPTLPLVCNRTGAVLTGQT-PLDAQYWRRHSRQPVQFAE Mvan_1003|M.vanbaalenii_PYR-1 FESCAARLAYAAPTRPLVCNRTGAVVTGPG-VIDAQYWRRHARQPVQFAE Mb2971c|M.bovis_AF2122/97 FARVAARVQAREPQLGLVSNVTGELAGPD--FGSAQYWVDHVRRPVRFAD MLBr_00135|M.leprae_Br4923 FVRVAAQVEVRKPQIGLVSNVTGELAGPD--FGSPQYWGEHVSRAVRFVD MUL_2005|M.ulcerans_Agy99 FARIAAQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAVRFAD MAV_3108|M.avium_104 FAAAAAGIEPRPPRIPLVSNLTGQLAGPG--YGTPQYWVDHVRRPVRFVD MMAR_3796|M.marinum_M FGSAISGITVGEPTISVVSNVTAALGGPE--YGSPQYWVDHVRQPVRFAD Rv2048c|M.tuberculosis_H37Rv FAAVAAGIAIGRPTIGVISNVTGQLAGDD--FGSAAYWRRHIRQAVRFAD TH_2454|M.thermoresistible__bu LARLTSTLTPKPAAVPLYSTALADPRSTAA--RDEHYWVANLRGRVRFAE : : . . : .. . ** : *:*.: Mflv_0405|M.gilvum_PYR-GCK SVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAAPRAIA-SLRKGVAD MAB_0939|M.abscessus_ATCC_1997 SVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAPPRAIV-SLRKGVED MSMEG_0408|M.smegmatis_MC2_155 SVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHMAAPRAVA-SLRKGVAD Mvan_1003|M.vanbaalenii_PYR-1 SVRTLADLGCSVLMEIGPQPFLIAAALRVWPESAATPRAIP-SLRKGPDA Mb2971c|M.bovis_AF2122/97 SARHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEAMVVS---MLGKDRPE MLBr_00135|M.leprae_Br4923 SARHLQTLGATHFIESGPSSGLMGAIEQSLAPAEAVVVS---MMGKDRPE MUL_2005|M.ulcerans_Agy99 SARQLHTLGVTHFVEVGPGSGLTGSIEQSLAPAEAVVVS---MLGKDRPE MAV_3108|M.avium_104 GVRLAESQGAGVFLEVGPGAALTSAVEQSLTSDRAMSVV---TMPKGRPE MMAR_3796|M.marinum_M SVRLLESMGATRFVEVGPGAGLSTSVEQSLASPEDVVVIP--VLGKQRPE Rv2048c|M.tuberculosis_H37Rv SVRFAQAAGGSRFLEVGPSGGLVASIEESLP-DVAVTTMS--ALRKDRPE TH_2454|M.thermoresistible__bu AVTAAAEDGHRLFLEVSAHPVVCHSMAETLALAEVGEHAVLPVLRREQPE .. * ::* .. : : . . : : Mflv_0405|M.gilvum_PYR-GCK RRQIADALAAAYIGGHKPDFAALHEQ-RGVRLELPTYPFQRRRFWPK--- MAB_0939|M.abscessus_ATCC_1997 RRQIADALASAYVSGHRPNFAALQRH-PRRTVELPTYPFQRRRFWPK--- MSMEG_0408|M.smegmatis_MC2_155 RRQIADALASAYVGGHRPDFAAVHRQ-PRRPVELPTYPFQRRRFWPK--- Mvan_1003|M.vanbaalenii_PYR-1 RRQLAEAVAAAYIAGHRLDFTGHDGG-PHRRLPLPTYPFQHRSYWPK--- Mb2971c|M.bovis_AF2122/97 LASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETPGA MLBr_00135|M.leprae_Br4923 LASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGT MUL_2005|M.ulcerans_Agy99 VASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWEVPGA MAV_3108|M.avium_104 VDSLLTAAARLFTAGADVRWSAAFTGLHARRVDLPTYAFARRRFWLSGDA MMAR_3796|M.marinum_M GSSALHAAAVLFTTGATLDWSAVFDHTPAQRITLPTYAFQRRRFWLD-GT Rv2048c|M.tuberculosis_H37Rv PATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRFWLS-GD TH_2454|M.thermoresistible__bu LPAVAAVVGALYCHGAPVRP--AFPPGTRWATGLPGTQWQHRRFWRT--P . . : * ** : :* :* Mflv_0405|M.gilvum_PYR-GCK SAGMAIDGRVGASAGSGILGSGKD-LASGDSVYTSRLSVKTQPWLSDHVI MAB_0939|M.abscessus_ATCC_1997 SSGTAIEG--GGGLPSGILGRGED-LASGDSVYISRLSVRSQPWLSDHVI MSMEG_0408|M.smegmatis_MC2_155 ASSIAVDG---GTAASGILGSGKD-LASGDTIYTSRLSVKSQPWLADHVI Mvan_1003|M.vanbaalenii_PYR-1 TAGIRSDG----SSGSGLLGSAQD-LASGDIVHTSRLSVKTQPWLSDHVI Mb2971c|M.bovis_AF2122/97 DGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV MLBr_00135|M.leprae_Br4923 DGTASVSGLGLGSTEHALLGAVVERPDSGGVVLTGRLSLANQPWLADHVI MUL_2005|M.ulcerans_Agy99 DGPADATGLGLGGAEHALLGAVVERPDSGGVVLTGRLALADQPWLADHVI MAV_3108|M.avium_104 VGSANIASLGLAEAEHPLLGAVLDRPDSGGVVLTGRLSTAAQPWLADHAV MMAR_3796|M.marinum_M SRAGDVGNVGLAAVAHALLGAVITQPDSGGVILTGLLTPRTQPWLADHRI Rv2048c|M.tuberculosis_H37Rv GVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV TH_2454|M.thermoresistible__bu GTPPGGVGVHDVDSHTLLGGRIDVAGAVPARVWQTRLDLSTRPYPGDHPV . : * : * : : .** : Mflv_0405|M.gilvum_PYR-GCK YGTVVVPGATYAAMALAAVGTP--AHAKDVFFYEPIILPEKSSREVQLTV MAB_0939|M.abscessus_ATCC_1997 YGTVVVPGATYAAMALAAVGTP--ARAKDVFFYEPIILPEKSSREVQLTL MSMEG_0408|M.smegmatis_MC2_155 YGTVVVPGATYAAMALAAVGTP--ARLKDVFFYEPIILPEKASREVQLTL Mvan_1003|M.vanbaalenii_PYR-1 YGTVVVPGATYAAMALAAMPTP--ARVQEVFFYEPIILGDKDSREVQLML Mb2971c|M.bovis_AF2122/97 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVV MLBr_00135|M.leprae_Br4923 GGVVLFPGAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVV MUL_2005|M.ulcerans_Agy99 GGVVLFPGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQVQVIV MAV_3108|M.avium_104 AGTVLFPGAGFVELALRAGDEVGCPVVEELTLSAPLSLPAGGTVQLQVVV MMAR_3796|M.marinum_M AGVMLFPGAGFVELAIRAGDEVNCPVLHELTLMAPLAISESG-VPVQVMV Rv2048c|M.tuberculosis_H37Rv AGVTIFPGAGFVELAIRAGDEVGCGVVDESTLAAPLVLPASGSVAVQVVV TH_2454|M.thermoresistible__bu QGTEIVPAAVLLNTFLTAAGSD----IADVRLRTPVAPARTRDVQVVLQD *. :.*.* : * : : *: : : Mflv_0405|M.gilvum_PYR-GCK HPSVDGE-SKFQVHSRPYGERGAEWALNAEGVVASGVGD---SPAAAGDL MAB_0939|M.abscessus_ATCC_1997 HPLEDGSGSKFQVHSRPYGERDVDWSLNAEGTVVTGIGDDAEPAPEAAEP MSMEG_0408|M.smegmatis_MC2_155 HPADGGSVLSFQIHSRPYGERGADWSLNAEGTVDTAGSD---PDAAADEQ Mvan_1003|M.vanbaalenii_PYR-1 HRTDDADGWTFEVHSRPYGDRDADWSRNASGTVAAGVGD-----AAPDAA Mb2971c|M.bovis_AF2122/97 G-AADESGHRAVSVYSRGDQSQG-WLLNAEGMLGVAAAET---------P MLBr_00135|M.leprae_Br4923 A-AADESSRRAVSVYSRGDQSHGGWLLNAEGLLEVDAAEA---------T MUL_2005|M.ulcerans_Agy99 G-TADDSGNRALSVYSRGDKSED-WLLNAEGMLGVEAASS---------G MAV_3108|M.avium_104 ADAAGQPGSRSVAVYSR--VAQSEWTLHAEGVLSEAAPAP---------A MMAR_3796|M.marinum_M G-AAGESGSRTVAVYSAEGQSDSEWILHAKGVLTVGTAEPS------LMS Rv2048c|M.tuberculosis_H37Rv N-GPDESGVRGVSVYSR-GDVGTGWVLHAEGALRAGSAEP---------T TH_2454|M.thermoresistible__bu R-----------------------ALALASRIVGEDTTAR---------A *. : Mflv_0405|M.gilvum_PYR-GCK EDPVDEAIERLNRMRPQELFETFADLELAWGPTWSGSLKSLWLGEGEAIG MAB_0939|M.abscessus_ATCC_1997 AEPVDAAIERMERMRPMELFEIFADLELAWGPTWSGSLKSLWLGEGEAIG MSMEG_0408|M.smegmatis_MC2_155 SDPVDEVIERLERMRPQDLFETFADLELAWGPTWSGSLKSLWLGDGEAVG Mvan_1003|M.vanbaalenii_PYR-1 ADPVDNAIERLTRTRPQQLFDAFADNDLAWGPAWCSSLRSLWVGTGEAVG Mb2971c|M.bovis_AF2122/97 MDLSVWPPEGAESVDISDGYAQLAERGYAYGPAFQG-LVAIWRRGSELFA MLBr_00135|M.leprae_Br4923 VDLSLWPPEGAESVDISDAYPQLAERGYAYGPAFQG-LVAIWRRGSELFA MUL_2005|M.ulcerans_Agy99 ADLSVWPPEGAESVDISDGYAQLADRGYAYGPGFQG-LVGVWRRDSELFA MAV_3108|M.avium_104 AELSVWPPADAEAVDVAGGYDDLAGRGYGYGPAFRG-LRAVWRRGAETFA MMAR_3796|M.marinum_M SELSAWPPAGAEVLDIAGGYDRLAGLGYQYGPAFQG-LTAVWKRGEDVFA Rv2048c|M.tuberculosis_H37Rv ADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRG-LTAMWRRGDEVFA TH_2454|M.thermoresistible__bu TAGRDTTDRDTTACDTTDRDTTACDDPGVWLTHCTARVADDHVGAEGVLD . : . . : . Mflv_0405|M.gilvum_PYR-GCK DILVGAELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLYLPL MAB_0939|M.abscessus_ATCC_1997 DVLVGEELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPL MSMEG_0408|M.smegmatis_MC2_155 DILVGAELAEQLGSEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPL Mvan_1003|M.vanbaalenii_PYR-1 DIAVGAELGEHLGREPIHPVLLDLCTGIAGAALLAAAAQTDADPELFLPL Mb2971c|M.bovis_AF2122/97 EVVAPGEAGVAVDRMGMHPAVLDAVLHALGLA----VEKTQASTETRLPF MLBr_00135|M.leprae_Br4923 EVVAP--TGVVVDGMGMHPALLDAVLHALGLA----IENTQATTEMRLPF MUL_2005|M.ulcerans_Agy99 EVVAP--SGVAVDKMGMHPVVLDAVLHALGLT----AEQNPDSDETKLPF MAV_3108|M.avium_104 EVELPEQAGVSTGRFGIHPVLLDAALHALGVA----DKR----LETVLPF MMAR_3796|M.marinum_M EIAVSEDL--DVAGMEIHPALLDAALHAWVLAS-DAEGAASRDEGVQLPF Rv2048c|M.tuberculosis_H37Rv EVALPADAGVSVTGFGVHPVLLDAALHAVVLS---AESAERGQGSVLVPF TH_2454|M.thermoresistible__bu EEAIRARCPQPLPAGHVVDTLAGLGVAAMGFG------------------ : : .: . Mflv_0405|M.gilvum_PYR-GCK RYGQVSLQEKMPRRFYCRATWHEAPLDSETQVFDLEYLDRDGRHLGGVRE MAB_0939|M.abscessus_ATCC_1997 RYGQVTLKEKMPRRFYCRARWHESPLDSETQVFDLDYLDRDGRHLGGIRE MSMEG_0408|M.smegmatis_MC2_155 RYGQVTLAEKMPRRFYCRARWHRSALDSETQVFELEFVDLGGRALGGIRE Mvan_1003|M.vanbaalenii_PYR-1 RYGRVEVRERMPRRFYCRARWQTGGIDSETQVFDLDFLDHDGRNLGGIRE Mb2971c|M.bovis_AF2122/97 CWRGVSLHAGGAGRVRARFAS------AGADAISVDVCDATGLPVLTVRS MLBr_00135|M.leprae_Br4923 CWRGVSLHAGGAGRVRARFTS------AGADAIAVDIADSAGLPVLTVRS MUL_2005|M.ulcerans_Agy99 CWRGVSLHAGGAGRVRARLTM------SGPDSISVEIADAAGLPVLTVGA MAV_3108|M.avium_104 SWQGVSLHAAGASRVRVRLAP------AGAGAVSVELADASGVPVLSVRE MMAR_3796|M.marinum_M MWQQVSLHGVGATRLRVHLAR------TQSNVVDVQLCDTSGMLVFTG-S Rv2048c|M.tuberculosis_H37Rv SWQGVSLHAAGASAVRARIAP------VGPSAVSIELADGLGLPVLSVAS TH_2454|M.thermoresistible__bu -WEVLELHRGEGELFARVAAEP----DKSAPATWAGLIDAATSTASTIFD : : : . . * Mflv_0405|M.gilvum_PYR-GCK FTVKRAPREALLRGLGGDATRLLYTLGWHEVPVP----ESGDGAAPQGTW MAB_0939|M.abscessus_ATCC_1997 FTVKRAPREALLRGLGGDATRLLYTLGWHEVAVPPVAGEGEESAASIGTW MSMEG_0408|M.smegmatis_MC2_155 FTVKRAPREALLRGLGGDATRLLYTLGWHEVPPP------PSADDAVGTW Mvan_1003|M.vanbaalenii_PYR-1 FTVKRAPREALLRGLGADATRLIYRVGWRETSPP---VRDDGALGPSSTW Mb2971c|M.bovis_AF2122/97 LVTRPITAEQLRAAVTAAGG-ASDQGPLEVVWSP-----ISVVSGGANGS MLBr_00135|M.leprae_Br4923 LVTRAMTAEQLRTAVTAAGG-ALEQGPMDLVWSP-----IPLSSDGHGG- MUL_2005|M.ulcerans_Agy99 LVTRAMSAAQLRAAVAEAGGGAPDQGPLDVIWSP-----IPLSGSGTNGS MAV_3108|M.avium_104 LVTRAVSAEQLAAAVAVRSG---SGELLDVAWSV-----IEPRNSLPDNP MMAR_3796|M.marinum_M LLTRPVSPEKIHAALSAAGTQD-DSGLMELTWAP-----ITLPEGRAGRI Rv2048c|M.tuberculosis_H37Rv MLARPVTDQQLRAAVSSSGPD----RLFEVTWSP-----QPS-------- TH_2454|M.thermoresistible__bu GPPRLRMPARIERVHVRDKPPAIALLHVRRRPEG---------------- : : Mflv_0405|M.gilvum_PYR-GCK LIGGFDELAVSVPGCIPADR----------------TNPESLRQLLTDAH MAB_0939|M.abscessus_ATCC_1997 LIAGFDELAAKVPGCIPLNRE---------------TDPELLGEVLVAAK MSMEG_0408|M.smegmatis_MC2_155 LIAGFDELAAKVPGCVPIDRN---------------TDLQVLGEVLSQAH Mvan_1003|M.vanbaalenii_PYR-1 LVAGLDALADDVPGSIRIGFDRIWDPDRDGRVVLDPADDEHWRRLFALAD Mb2971c|M.bovis_AF2122/97 APPAPVSWADFCAGSDG--------------------------------- MLBr_00135|M.leprae_Br4923 GLPSVVSWADYCAGRGN--------------------------------- MUL_2005|M.ulcerans_Agy99 AQPAVVSWADFCAGGDGGAAG----------------------------- MAV_3108|M.avium_104 ISEGVTVWEPAAVDGAG--------------------------------- MMAR_3796|M.marinum_M VAWRDQSTVDPVSEADPAGGV----------------------------- Rv2048c|M.tuberculosis_H37Rv ------AAVEPLPVCAWGTTE----------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GRGLPFSGVVWRAARSDGDES--DAEVAARLEAEIAELLGAVHTVQ---G MAB_0939|M.abscessus_ATCC_1997 ERGVPFSGVVWRAAGPGATES--TTESAARLEGEIAHLLSAVHTVQNSAQ MSMEG_0408|M.smegmatis_MC2_155 ARGAGFSGVVWRCATPGRKESGSASAESARLEAEITNLLSAVHAAQ---G Mvan_1003|M.vanbaalenii_PYR-1 ERRAPVAGVVLGVTGRARPEE-PSADFAARLEAQIRDVLGAVHSLS---A Mb2971c|M.bovis_AF2122/97 -----DASVVVWELESAGGQASS---VVGSVYAATHTALEVLQSWLG--- MLBr_00135|M.leprae_Br4923 -----DTGVVVWEFGSASAGAQAPVDSVAAVYSATHAALQVLQFWFG--- MUL_2005|M.ulcerans_Agy99 -----DAGVVVWEPNPAG------EDVVGPVYAATHAALEVLQSWFD--- MAV_3108|M.avium_104 ---------------------------PAAVHAATHQALGVLQSRLA--- MMAR_3796|M.marinum_M -----QADVVVWEVPATHR------DVVASVHEVTHQLLAVLQSWLT--- Rv2048c|M.tuberculosis_H37Rv -----DSAAVVFESVPLAG------DVVAGVYAATSSVLDVLQSWLT--- TH_2454|M.thermoresistible__bu -------------------------TVTDVTIAEESGAVSVTLTGMG--- : . Mflv_0405|M.gilvum_PYR-GCK GEVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTAINEEPALRCRL MAB_0939|M.abscessus_ATCC_1997 NGVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEEPALRAKL MSMEG_0408|M.smegmatis_MC2_155 PSVKLPGGLWIVTEHGVACESGEPVDPVQAALWGFGRTTINEEPALHCRL Mvan_1003|M.vanbaalenii_PYR-1 LGAKPAAGLWIVTERAVAAEAGEPVDPVQSALWGLGRTLIAEEPGLRCLL Mb2971c|M.bovis_AF2122/97 --ADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENP-GRIVL MLBr_00135|M.leprae_Br4923 --QDRAGTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHS-GKIVL MUL_2005|M.ulcerans_Agy99 --GDRAGTLVVLTHGAVAMPGENVSDLAGAAVWGIVRSAQAENP-GRIVL MAV_3108|M.avium_104 --GEAGGVLVVSTRGAVGLPGEDVADLAGAAVWGLVRSAQAEHP-GRVVL MMAR_3796|M.marinum_M --VDRAGVLVVLTRGAVGLVGERVSDLAGAAVWGMVRSAQNEHP-GQVLL Rv2048c|M.tuberculosis_H37Rv --RDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHP-GRIVL TH_2454|M.thermoresistible__bu --------FEELENPGGGGSSGDLTGMLHHLRWHPVDWPDTDPP-AAVVL : . . . . . * : . * Mflv_0405|M.gilvum_PYR-GCK VDCDGSPQAVQALAALLSTP-VDEPELAVRQGKLLASRLLPWSRSGHLTV MAB_0939|M.abscessus_ATCC_1997 VDGDGSPEAVQALARLLVTP-VDEPEIAVRQGKLLASRLLPWSRTGHLTV MSMEG_0408|M.smegmatis_MC2_155 VDCDGSSEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWARSGHLTL Mvan_1003|M.vanbaalenii_PYR-1 VDLDGSEDAGPALARLLGAP-GDEPELALRQGRLLVPRLLPWSRSGQLAI Mb2971c|M.bovis_AF2122/97 IDTDAAVDASVLAG-------VGEPQLLVRGGTVHAPRLSPAP--ALLAL MLBr_00135|M.leprae_Br4923 IDTDSAVDVAVLAD-------LGESQLLVRCNTVHAARLSPAP--QLLAL MUL_2005|M.ulcerans_Agy99 VDADAAVEAAELVA-------VGEPQLVVRSGAAHAARLAPAA--PLLAV MAV_3108|M.avium_104 VDTDGSLDLATVIG-------CGEPQLVVRDGVAYRARLRPAGRRALLEL MMAR_3796|M.marinum_M VDLDA-----------------------------------AASIVDGQIV Rv2048c|M.tuberculosis_H37Rv VDSDAPLDDSALAAVV----TTGEPQVLWRRGEVYTARVHGSRAVGGLLV TH_2454|M.thermoresistible__bu VGGDAR-------------------------------------------- :. *. Mflv_0405|M.gilvum_PYR-GCK PRGGD-YVLAPTERGAIDNLRLTDSEVPPP--AEGYVQVRVEAAGLNFRD MAB_0939|M.abscessus_ATCC_1997 PRGSD-YVLAPTERGAIDNLRITEKEVPAP--DEGYVQVRVEAAGLNFRD MSMEG_0408|M.smegmatis_MC2_155 PRGGD-FVLAPTERGAIDNLRLTETDVPEP--DEGYVQVRVEAAGLNFRD Mvan_1003|M.vanbaalenii_PYR-1 PRGTD-YVLAPTERGVLDNLRVSETEVTAP--PEGHVQVRVEAAGLNFRD Mb2971c|M.bovis_AF2122/97 PAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRD MLBr_00135|M.leprae_Br4923 PVGESMWRLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNFRD MUL_2005|M.ulcerans_Agy99 PADESAWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAVGVNFRD MAV_3108|M.avium_104 PGPPAVWRLAAGDAGTLEDLAVQEHP--AAELAPGQVRVRVAAAGVNFRD MMAR_3796|M.marinum_M TDSD----------------------------GSDMRGLDLAALTK---- Rv2048c|M.tuberculosis_H37Rv PPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRD TH_2454|M.thermoresistible__bu --------------------------------TRAFVTRDLDEARVAHR- : Mflv_0405|M.gilvum_PYR-GCK VLNVLGLYPGDPGPIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQGAFASR MAB_0939|M.abscessus_ATCC_1997 VLNVLGLYPGDPGPIGGDFAGIVTQLGEGVTGVEVGQRVYGSMQGAFGSR MSMEG_0408|M.smegmatis_MC2_155 VLNVLGLYPGDPGPIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQGAFASR Mvan_1003|M.vanbaalenii_PYR-1 VLNALGLYPGDPGPIGGELAGVVTAPGPDVDGFDVGQRVFGFAVGAFASR Mb2971c|M.bovis_AF2122/97 VVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLG-GAGPL MLBr_00135|M.leprae_Br4923 VVAALGMYPGQAPPLGAEGAGVVIEIGPEVTGVAVGDAVMGFLG-GAGPL MUL_2005|M.ulcerans_Agy99 VVAALGMYPGAAPPLGAEGAGVVLEVGPQVSGVAVGDSVMGFLG-GAGPL MAV_3108|M.avium_104 VLVALGMYPGAAQ-LGAEGAGVVTEVGAGVTDVAVGDAVMGIFG-LVGSE MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VMIALGLYPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTV TH_2454|M.thermoresistible__bu ---------------------------------------------SYADP Mflv_0405|M.gilvum_PYR-GCK FNVPGQFLAPIPDGVSAVEAATIPAAALTVRLS-FDWAQVKSGDKVLIHA MAB_0939|M.abscessus_ATCC_1997 FNVPAQFLAPIPDGISGVEAATIPAAALTVRLS-FDWAQLKPGDKVLIHA MSMEG_0408|M.smegmatis_MC2_155 FNVPAQFLAPIPDGIGAVEAATIPAAALTVRLA-FDWAQLKPGDKVLIHA Mvan_1003|M.vanbaalenii_PYR-1 VNVPVQFLAPVPEGISAVAAATTPAAVLTAGLA-FDWAALRAGDRVLIHA Mb2971c|M.bovis_AF2122/97 AVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHA MLBr_00135|M.leprae_Br4923 AVVHQQLITQMPQGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLIHA MUL_2005|M.ulcerans_Agy99 SVVDQQLITRMPQGWSFAQAAAVPVVFLTALFGLQDLAKIQPGESVLIHA MAV_3108|M.avium_104 AAVDRRLVTRVPPGWSMAQAAGIPVVFLTAYYGLSVLAGLRAGQRVLVHA MMAR_3796|M.marinum_M -SGETQLVVRS--------------------------------------- Rv2048c|M.tuberculosis_H37Rv ASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARSGQRVLIHA TH_2454|M.thermoresistible__bu AALPPDLTAGTVVLVLPRTAARPAASAQLVLHTLQRLSATNSGARLWVLT : . Mflv_0405|M.gilvum_PYR-GCK ASGGVGLAAVQMAQQCGAEVYATASTFKRATLRKLG--VKHVYDSRTTDF MAB_0939|M.abscessus_ATCC_1997 ASGGVGLAAIQMAQQFGAEVFATASTFKRATLRKLG--VKYVYDSRTTDF MSMEG_0408|M.smegmatis_MC2_155 ASGGVGLAAIQMAQQSGAEVFATASTFKRSTLRRLG--VKYVYDSRTTDF Mvan_1003|M.vanbaalenii_PYR-1 ASGGVGLAAVQLARQRGATVFATASGYKRPMLRAMG--VDHVYDSRTTDF Mb2971c|M.bovis_AF2122/97 GTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEF MLBr_00135|M.leprae_Br4923 GTGGVGMAAVQFARHWGVEIFVTASRGKWDTLRDMGFDDDHIGDSRTLEF MUL_2005|M.ulcerans_Agy99 GTGGVGMAAVQLARHWGVEIFVTASRGKWDTLRAMGFDDDHIGDSRTLDF MAV_3108|M.avium_104 ATGGVGMAAVQLARHWGAEVFATASRGKWDTLRAMGFDDAHIADSRTLDF MMAR_3796|M.marinum_M ---------------------------------------QQVYAARLSAM Rv2048c|M.tuberculosis_H37Rv GTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEF TH_2454|M.thermoresistible__bu RGVHEGTDPGHGPLWGLARVAAAEHPQLWGGLLDIG----------EDRL : Mflv_0405|M.gilvum_PYR-GCK AEQILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDIWTV MAB_0939|M.abscessus_ATCC_1997 ADQILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDIWTT MSMEG_0408|M.smegmatis_MC2_155 ADQILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDIWSH Mvan_1003|M.vanbaalenii_PYR-1 ADQILADTDGAGVDVVLNSLTNDGFVAATVRATARNGRFAEIAKRDIWSP Mb2971c|M.bovis_AF2122/97 EEKFLAVTEGRGVDVVLDSLAGE-FVDASLRLLVRGGRFLEMGKTDIRDA MLBr_00135|M.leprae_Br4923 EEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDIRDA MUL_2005|M.ulcerans_Agy99 EEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDIRDA MAV_3108|M.avium_104 EQKFGAAPG--GMDVVLNSLAGE-FNDASLRLLGPGGRFIEMGKTDLRDP MMAR_3796|M.marinum_M APTLEVADGGG---------------------VKP---------SSMLDP Rv2048c|M.tuberculosis_H37Rv EDKFRAATGGRGFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDIRDP TH_2454|M.thermoresistible__bu PVRALTALTGHGVVVVRDGVAHT------ARLAPAGPGARDSAGEGLRCS . .: Mflv_0405|M.gilvum_PYR-GCK EQMAAARPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDGAWTPLPAE MAB_0939|M.abscessus_ATCC_1997 EQMAQSRPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKGEWTPLPAE MSMEG_0408|M.smegmatis_MC2_155 EQMAEARPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARGEWTPLPAE Mvan_1003|M.vanbaalenii_PYR-1 EQMAAARPDIDYEVLALDAVMQQDPDRIQLLLADLADSLARGETAPLPFE Mb2971c|M.bovis_AF2122/97 QEIAANYPGVQYRAFDLSEAG---PARMQEMLAEVRELFDTRELHRLPVT MLBr_00135|M.leprae_Br4923 QEIAANYPGVQYRAFDLSEAG---PVRMQEMLCEVRELFDTQVLHRLPVT MUL_2005|M.ulcerans_Agy99 DKIAANYPGVWYRAFDLSEAG---PVRMQEMLAEVRELFDTAVLHRLPVT MAV_3108|M.avium_104 DVVARAHPGVRYRAFDLMEAG---PDRIAAMLAEVMELFAAGALTPLPVK MMAR_3796|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv GVIAQQYPGVRYRAFDLFEPG---PDRIAQILAELATLFGDGVLRPLPVT TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VYPLTEARAAFRRMQQARHIGKIVVQIPNPLQP-QPDRSYLITGGLGAIG MAB_0939|M.abscessus_ATCC_1997 IYPLTEARTAFRRMQQARHIGKIVCQMPNPLAP-RPDRTYLITGGLGAIG MSMEG_0408|M.smegmatis_MC2_155 IYPITEARSAFRRMQQARHIGKIVLQVPKPLQP-QQDRSYLITGGLGAIG Mvan_1003|M.vanbaalenii_PYR-1 AYPLAEATTAFRRMQQARHTGKIILQMPKPLQP-HGDRSYLITGGLGALG Mb2971c|M.bovis_AF2122/97 TWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVG MLBr_00135|M.leprae_Br4923 SWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLAEGTVLITGASGAIG MUL_2005|M.ulcerans_Agy99 TWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLADATVLITGATGAVG MAV_3108|M.avium_104 AFDARCAADAYRFVSAARHIGKVVLTMPDGPAG-LSGGTALITGATGMAG MMAR_3796|M.marinum_M ------------------------------------SGTVLITGGTGMAG Rv2048c|M.tuberculosis_H37Rv TFDVRCAPAALRYLSQARHTGKVVMLMP----GSWAAGTVLITGGTGMAG TH_2454|M.thermoresistible__bu -----------------------------------PGGTYLITGGTGALG : :***. * * Mflv_0405|M.gilvum_PYR-GCK -LHTAGYLAQLGAGDIVLTSRRAPDA---------AAQQAIADIADRTKA MAB_0939|M.abscessus_ATCC_1997 -LHTAAYLAQLGAGDIVLTSRRAPDT---------DAQRVIGEITERSKT MSMEG_0408|M.smegmatis_MC2_155 -LHTAAYLAQLGAGDIVLTSRRDPDE---------SAQRAIDEITERHKC Mvan_1003|M.vanbaalenii_PYR-1 -LHAAAYLAQLGAGDIVLTGRRMPDA---------ATERAISEIAERYHC Mb2971c|M.bovis_AF2122/97 GVLARHLVGAYGVRHLVLASRRGDRA---------EGAAELAADLTEAGA MLBr_00135|M.leprae_Br4923 GVLARHMVSAYGVRHLVLASRRGDRA---------EGAVELAAELVGAGA MUL_2005|M.ulcerans_Agy99 AVLARHMLDGYGVRHLVLASRRGDRA---------EGAAELAAELSEAGA MAV_3108|M.avium_104 AALARHLVARHRVPHLMLVGRRGEAA---------PGMAELAAELRGAGA MMAR_3796|M.marinum_M GWLARHVVDHYGVRHVLLASRSGDRA---------GGSAEIAAELAARGV Rv2048c|M.tuberculosis_H37Rv SAVARHVVARHGVRNLVLVSRRGPDA---------PGAAELVAELAAAGA TH_2454|M.thermoresistible__bu -LRLAHRLADLGARRLVLVSRSGMPARDSWGRAGDSDTVAAITALEERGV : . ::*..* Mflv_0405|M.gilvum_PYR-GCK RLHVFTADVGVEADVAALLERIRAELPPLAGVAHLAGVLDDALLSQQSVE MAB_0939|M.abscessus_ATCC_1997 RIHVFTADVGAESEVAGLLERIRAELPPLAGVAHLAGVLDDALLGQQSVE MSMEG_0408|M.smegmatis_MC2_155 RIHTYAADVGDEAQVADLLARIRAELPPLAGIAHLAGVLDDALLSAQNPE Mvan_1003|M.vanbaalenii_PYR-1 RIHTFAADVGDESAVRDLLERIRTELPPLAGVAHLAGVLDDALLPQQSPE Mb2971c|M.bovis_AF2122/97 KGQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPD MLBr_00135|M.leprae_Br4923 KIQVVACDVADNDAVRGLFAQLSREFPPVRGVIHAAGVLDDGAITSLTPD MUL_2005|M.ulcerans_Agy99 NVQVVACDVADRDAVEAMLARLSGEYPPVRGVIHAAGVLDDAVISSLTPE MAV_3108|M.avium_104 SVSVLSCDVGDRDAVAAMLAQVPARYP-LRSVFHAAGVLDDAVIASLTPA MMAR_3796|M.marinum_M QVEVVACDVADRDAVTALLARLPQQYP-LTGVIHAAGVLDDAVITSLTPD Rv2048c|M.tuberculosis_H37Rv QVQVVACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPD TH_2454|M.thermoresistible__bu SVRVAALDIG-APGAAARLREVLADLPDVRGVIHAAGVEAGALLTNTTAE . : * . : : * : .: * **. .. : . Mflv_0405|M.gilvum_PYR-GCK RFRTALAPKAFGAVHLDRLTRVDDLDFFLVSSSVSSLFGSPGQSNYATAN MAB_0939|M.abscessus_ATCC_1997 RFRTTLAPKAFGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQSNYATAN MSMEG_0408|M.smegmatis_MC2_155 RFRTTLAPKAYGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATAN Mvan_1003|M.vanbaalenii_PYR-1 RFRTTLAPKAFGAWHLHRLTRDTELEFFIVYSSGSSVLGSPGQANYATAN Mb2971c|M.bovis_AF2122/97 RIDTVLRAKVDAAWNLHQATSDLDLSMFVLCSSIAATVGSPGQGNYSAAN MLBr_00135|M.leprae_Br4923 RVDTVLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATVGSPGQGNYSAAN MUL_2005|M.ulcerans_Agy99 RIDTVLRAKVDAAWNLHEATLDLDLSMFVLCSSIAATVGSPGQGNYSAAN MAV_3108|M.avium_104 RIDTVLRAKVDGAWNLHELTKDLDLSAFVVFSSMAGIVGAPGQGNYAAAN MMAR_3796|M.marinum_M RVDTVLRAKVDAAWNLHELTRDLGVSAFVLFSSIAGTVGAPGQGNYAAAN Rv2048c|M.tuberculosis_H37Rv RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAAN TH_2454|M.thermoresistible__bu DIEATMRPKVDGVLALHEVFPPGRLDWLVLFSSCGYLGGFPGQGAYACGN . ..: .*. .. *.. : ::: ** . * .**. *: .* Mflv_0405|M.gilvum_PYR-GCK AFLDGLVAQRRAQGLPATGVNFGPWARGGMASSEAAAAN---ISAQGLIP MAB_0939|M.abscessus_ATCC_1997 ALLDGLIAQRRAQGLPATGINFGPWGQGGMASSEAATAN---ISAQGLIP MSMEG_0408|M.smegmatis_MC2_155 AMLDGLVAKRRAQGLVATGINFGPWGQGGMASSEAATAN---ITAQGLIP Mvan_1003|M.vanbaalenii_PYR-1 AVLDGLVAHRKARGLPATGVNWGPWAQGGMATSDAARAN---LGAQGLIP Mb2971c|M.bovis_AF2122/97 AFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP MLBr_00135|M.leprae_Br4923 AFLDGLAAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSRDLARISRSGLAP MUL_2005|M.ulcerans_Agy99 SFLDGLAAHRQAAGLAGISVAWGLWEQSGGMAAHLSSRDLARMSRSGLAP MAV_3108|M.avium_104 SFLDALAIHRHAHGLPALSVAWGMWEEPSAMTAHLEERDKARMSRAGLSA MMAR_3796|M.marinum_M AFLDALAFQRRADGLTATSLAWGLWERSSTMTGHLSSRDMTRMNRTGMVA Rv2048c|M.tuberculosis_H37Rv SFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA TH_2454|M.thermoresistible__bu AYLDAFARYRRASGDATTSVAWTAWRGLG--MGSASDFVAAQLDALGMGT : **.: *:* * .: : * . . : *: . Mflv_0405|M.gilvum_PYR-GCK LEPSAALTAMAEVVANGTAQATVLKAN-WQRAAKVLGSSRPPILDLVLPS MAB_0939|M.abscessus_ATCC_1997 LDPSAALAALAEVVANGTGQATILKAN-WQRAAKVLGSSRPPILDLVLPS MSMEG_0408|M.smegmatis_MC2_155 LDPSAALHALAEVIANGSGQATVLKAN-WQRAAKVLGSARPPILDLVLPS Mvan_1003|M.vanbaalenii_PYR-1 LEPTAALNALGEIVAHGIASAVVLKAN-WQRAAKLLGATRPPILDHVLPS Mb2971c|M.bovis_AF2122/97 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARR MLBr_00135|M.leprae_Br4923 MNPAQALELFDAALVIDHPFMVTALLDRAALDAQAQAGALPPLFSRLVRR MUL_2005|M.ulcerans_Agy99 MNPEQAVGLLDAVLAINHPLMVATLLDRPALEARAQAGGLPPLFAGVVRR MAV_3108|M.avium_104 LSTRQALDLLDDALLGEQPLVVGTRLDRAALAQHRAA--LPPLLSELAGR MMAR_3796|M.marinum_M LTAEQAVEMFDAALVAGHPAVVAGRFDRRMLHNPSFNAGLPPLFNELIGS Rv2048c|M.tuberculosis_H37Rv MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINA TH_2454|M.thermoresistible__bu VDVDDAMRALDAAIRDGDPNVVVLPLSPAAAAVPMFADVAPADPDADAP- : *: : : . *. Mflv_0405|M.gilvum_PYR-GCK AVG--------EITGDSELLKQLQEIPVPQRAGFVTEFLQKEVQNFLRLA MAB_0939|M.abscessus_ATCC_1997 AVG--------EVTGDSELLKQLMEIPVPQRAGFVTEFLQREVQNFLRLA MSMEG_0408|M.smegmatis_MC2_155 AAG--------EATGDSELLKQLMEIPIPQRAGFVTEFLQREVQNFLRLA Mvan_1003|M.vanbaalenii_PYR-1 AVA--------AGPGDSALLKQLQDVPEAQRGSFVTEHLQRELQQILGLA Mb2971c|M.bovis_AF2122/97 PRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRP MLBr_00135|M.leprae_Br4923 SRRRQIEDPGDATQSKLALVQRLQGLAANRQLELLVGVVCLQAAAVLGRP MUL_2005|M.ulcerans_Agy99 PRRRQIEDTGDAAQSKSALAERLNGLSAGERQDALVGLVCLQAAAVLGRP MAV_3108|M.avium_104 PARRMLEHT--DMVSLTGLRARLAGMNPEQRQAELVELVCGNAAAVLG-H MMAR_3796|M.marinum_M PRRRTIEAGSLASQS--ALTQRLHGLTPEQQREMLTELVCTQIAIALGHN Rv2048c|M.tuberculosis_H37Rv PTRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSA TH_2454|M.thermoresistible__bu ---------GGEVPDGLSDGFPADGFPDDGDLAEWVHRRVIAAVAGELGL . . Mflv_0405|M.gilvum_PYR-GCK QPPAATS--RFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVFDYPTIG MAB_0939|M.abscessus_ATCC_1997 QPPAATS--RFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIG MSMEG_0408|M.smegmatis_MC2_155 SPPAASS--RFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIG Mvan_1003|M.vanbaalenii_PYR-1 QPPAATG--RFLELGMDSLMAVELRNRLVGQFGSGFTITATAVFDYPTIG Mb2971c|M.bovis_AF2122/97 SAEDVDPDTEFGDLGFDSLTAVELRNRLKTATG--LTLPPTVIFDHPTPT MLBr_00135|M.leprae_Br4923 SPEDIDPNTKFQDLGFDSLTAVELRNRLKSATG--LTLPPTVIFDHPTPT MUL_2005|M.ulcerans_Agy99 SPEDIDPEAGFQDLGFDSLTAVELRNRFKSATG--LTLPPTVIFDHPTPT MAV_3108|M.avium_104 STADVDPGDAFSDLGFDSLTAVELRNRLKIATG--LTLSPTVIFDHPTPA MMAR_3796|M.marinum_M NSSEINPDQAFQGLGFDSLTAVELRNRLKAATG--LSLTPTLVFDYPTPR Rv2048c|M.tuberculosis_H37Rv SPEAIDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSA TH_2454|M.thermoresistible__bu AETDVDPRLPLVEIGVDSIMTVALRRQLERQTG--LTLPPTLLWEHPTAG : :* **: :: :*.:: * ::: .* ::::*. Mflv_0405|M.gilvum_PYR-GCK GLAEYLVAQLPDAETPQAAP-------QSESEPGPDVTE----------- MAB_0939|M.abscessus_ATCC_1997 GLAEYLVGQLPDADAESAEAPPAVESAEAESGAGPAAASDAVSELKE--- MSMEG_0408|M.smegmatis_MC2_155 GLAEYLVGQLPDAEAPETA------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 ALAEYLAAQTPESTEEGTEMKTADPDGQPATVGHADVVLQTS-------- Mb2971c|M.bovis_AF2122/97 AVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA------------- MLBr_00135|M.leprae_Br4923 AVAEYVAQQMLKSRPAESGDETSQAVEPKVEEVSVHA------------- MUL_2005|M.ulcerans_Agy99 AIAEYVGRQIPDSQATQAEEE--KLPESDGEMVSVTA------------- MAV_3108|M.avium_104 ALAEHLGGQLTSAGPTPAAPAETAAPPDRSSRIDEVVSELQTLLTQPGLS MMAR_3796|M.marinum_M DVASYLEYQLGGSEPID-GGNDDYVRQVQELVMSIPAKRLA--------- Rv2048c|M.tuberculosis_H37Rv ALAGYMRRELLGSSPQDTSAVAAGEAELQRIVASIPVKRLR--------- TH_2454|M.thermoresistible__bu AVSDRIVEMLRARG------------------------------------ :: : Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 PGDRAQLVTRLQSLLSTPPQPSGHPEFPEDAFDDDIATATDSQLFAILDD MMAR_3796|M.marinum_M ---QANVVDLLQKLKTDISDQLDE----RESASNLADMSLDDLVDVALTK Rv2048c|M.tuberculosis_H37Rv ---QAGVLDLLLALANETETSGQDPALAPTAEQEIADMDLDDLVNAAFRN TH_2454|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ------ MAB_0939|M.abscessus_ATCC_1997 ------ MSMEG_0408|M.smegmatis_MC2_155 ------ Mvan_1003|M.vanbaalenii_PYR-1 ------ Mb2971c|M.bovis_AF2122/97 ------ MLBr_00135|M.leprae_Br4923 ------ MUL_2005|M.ulcerans_Agy99 ------ MAV_3108|M.avium_104 EAGP-- MMAR_3796|M.marinum_M FAAQQG Rv2048c|M.tuberculosis_H37Rv DDE--- TH_2454|M.thermoresistible__bu ------