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TIMRYDEAVDHALGQAMAADPRVLTWGEDVQILRRVLLSRFGPDRVRDTPISEQAFMYAGVGAAMAGLRP VVELYMIDFGTVGWSAIINAGSKFKDFSGGRWNVPMVLRAGVGGWYADGGEHEQTLWGTLASYPSTEVVV PSTPADAAGLMLSAVRSDEFTVFLTPKLLDQQILDYLGGDQRSTVDLTGVQPAAGVRGEVPDRVEPIPFG QAAIRRDGGDLTLVSVGVGVHRCLEAAERLSADGIEATVLDLRTLAPLDKEAIVEHVSRTGRVVVADEDY VRGGLTGEVAALLLEAGTSARYARVAVEQTIPFAPHLEYAVLPNAERIIAAAKSLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3322 | - | - | 100% (337) | pyruvate dehydrogenase E1 component (beta subunit) |
| M. marinum M | MMAR_3490 | - | 3e-52 | 36.07% (341) | pyruvate dehydrogenase E1 component (beta subunit) |
| M. marinum M | MMAR_3843 | pdhB | 8e-30 | 32.43% (333) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2524c | pdhB | 6e-29 | 30.63% (333) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. gilvum PYR-GCK | Mflv_3923 | - | 1e-08 | 28.74% (261) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. tuberculosis H37Rv | Rv2496c | pdhB | 3e-29 | 31.23% (333) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. leprae Br4923 | MLBr_01038 | dxs | 8e-09 | 27.92% (265) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. abscessus ATCC 19977 | MAB_0896c | - | 1e-35 | 32.66% (346) | putative pyruvate dehydrogenase E1 component, beta subunit |
| M. avium 104 | MAV_2948 | - | 1e-44 | 37.43% (342) | acetoin:2,6-dichlorophenolindophenol oxidoreductase beta |
| M. smegmatis MC2 155 | MSMEG_4711 | - | 1e-31 | 33.33% (336) | pyruvate dehydrogenase E1 component subunit beta |
| M. thermoresistible (build 8) | TH_4167 | - | 7e-48 | 37.24% (341) | PUTATIVE acetoin:2,6-dichlorophenolindophenol oxidoreductase |
| M. ulcerans Agy99 | MUL_3774 | pdhB | 2e-30 | 32.73% (333) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
| M. vanbaalenii PYR-1 | Mvan_0912 | - | 4e-66 | 42.99% (335) | transketolase, central region |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3322|M.marinum_M --------------------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu MATQLDVEAPTSANDRAIALYRLMSKVHHADARVRKGLSSGEIAMSYWPV
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK ------MLEQIRGPADLQHLSRAQMEDLAREIRDFLIHKVAATGGHLGPN
MLBr_01038|M.leprae_Br4923 ------MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPN
MMAR_3322|M.marinum_M --------------------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu TGQEAMSAGAALALSDGDQLVSTYRGLGDVVAKGIDLAGYFGEILGRRTG
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK LGVVELTLALHRVFDSPHDPILFDTGHQAYVHKMLTGRSRDFDTLRKKDG
MLBr_01038|M.leprae_Br4923 LGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRCQDFDSLRKKAG
MMAR_3322|M.marinum_M --------------------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu LSRGKAGAMGISDPDHGIAWTTGIVGAGPLFANGIALAASIRGTGQVVLV
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK LSGYPS----RSESEHDWVESSHASSALSYADGLAKAFELNGHRNRHVVA
MLBr_01038|M.leprae_Br4923 LSGYPS----RAESEHDWVESSHASTALSYADGLAKAFELAGNRNRHVVA
MMAR_3322|M.marinum_M --------------------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu SFGDGATSIGYVHEAMNMAALWNLPVVFFCQNNAWAECTAMERYTRTARL
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK VVGDGALTGGMCWEALNNIAASRRPVVIVVNDNGRSYAPTIG--------
MLBr_01038|M.leprae_Br4923 VVGDGALTGGMCWEALNNIAATPRPVVIVVNDNGRSYAPTIG--------
MMAR_3322|M.marinum_M --------------------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu SDRAQGYGMPGVTVDGTDPRAVHDAVAEAVTRARSGGGPTFVEALAYRLQ
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK ---------------GFAEHLAGLRLQPGYERVLEEGRKAVRGVPMIGEF
MLBr_01038|M.leprae_Br4923 ---------------GVADHLATLRLQPAYERLLEKGRDALHSLPLIGQI
MMAR_3322|M.marinum_M --------------------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu GHYFGDTMAYADPDELAAKRADPPFDRYRRRLIDEGIATAATLDQIDAEL
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK CYQCMHSIKAGIKDALSPQVMFTDLGLKYVGPIDG--------------H
MLBr_01038|M.leprae_Br4923 AYRFMHSVKAGIKDSLSPQLLFTDLGLKYVGPVDG--------------H
MMAR_3322|M.marinum_M --------MTIMR-------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------MTTTERS---------------------------------TR
MAV_2948|M.avium_104 ---------------------------------MAD-------------Q
TH_4167|M.thermoresistible__bu AAQVDAAFAAARDAEPLGPEELTGDVFTGNGTELADGTVPRVALPEGETE
Mb2524c|M.bovis_AF2122/97 --------MTQIADRPARP-----------DETLAVAVSD-------ITQ
Rv2496c|M.tuberculosis_H37Rv --------MTQIADRPARP-----------DETLAVAVSD-------ITQ
MUL_3774|M.ulcerans_Agy99 --------MTQIADPPARP-----------GPAPAAPVVG-------TMQ
MSMEG_4711|M.smegmatis_MC2_155 --------MTQIIDRPAAQGDAPEPWGSILTPAAAQAPVP-------AVT
MAB_0896c|M.abscessus_ATCC_199 ------------------------------------------------MT
Mflv_3923|M.gilvum_PYR-GCK DESAVEGALRHARAFNAPVVVHVVTRKGMGYAPAENDVDEQMHACGVIDP
MLBr_01038|M.leprae_Br4923 DEHAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMHTCGVMDP
MMAR_3322|M.marinum_M ---YDEAVDHALGQAMAADPRVLTWGEDVQ--ILRRVL------LSRFG-
Mvan_0912|M.vanbaalenii_PYR-1 KLTVAKAIVEAVTTEMERDPTVFALGEDIG--KYGGVFGQTAGLLDRFG-
MAV_2948|M.avium_104 EMTMREALNLALDQALAADERVFLLGEDIADPGASG---PTAGLSTKYG-
TH_4167|M.thermoresistible__bu ELGLVQAIHRTLDRAMAADDSIILLGEDIGDRSGGGMFKITAGLSAKYG-
Mb2524c|M.bovis_AF2122/97 SLTMVQAINRALYDAMAADERVLVFGEDVA--VEGGVFRVTEGLADTFG-
Rv2496c|M.tuberculosis_H37Rv SLTMVQAINRALYDAMAADERVLVFGEDVA--VEGGVFRVTEGLADTFG-
MUL_3774|M.ulcerans_Agy99 SLTMVQALNQALHDAMAADDRVLVFGEDVG--IAGGVFRVTEGLAETFG-
MSMEG_4711|M.smegmatis_MC2_155 ELTMVQAINRALRDAMAADERVLVFGEDVA--TLGGVFRVTDGLTESFG-
MAB_0896c|M.abscessus_ATCC_199 VTTMAQALNAALRDALHDDDSVVVFGEDVG--TLGGVFRVTDGLTETFG-
Mflv_3923|M.gilvum_PYR-GCK ETGLATSVPGPGWTAAFSETLIELAAKRRDIVAITAAMPGPTGLSAFRKR
MLBr_01038|M.leprae_Br4923 TTGQPTKIAAPDWTAIFSDALIGYAMKRRDIVAITAAMPGPTGLTAFGQC
: . : : :
MMAR_3322|M.marinum_M -PDRVRDTPISEQAFMYAGVGAAMAGLRPVVELYMIDFGTVGWSAIINAG
Mvan_0912|M.vanbaalenii_PYR-1 -PDRIIDTPISETGFIGAAVGAAVEGMRPIVELMFVDFFGVCMDQIYNHM
MAV_2948|M.avium_104 -CDRVLDTPISEAAIVGAAIGAAIDGLLPVAEIMIMDFIGIAADQLINNA
TH_4167|M.thermoresistible__bu -EERVRDTPIAESSIIGAALGASLAGLRPVAELMFMDFLGVAMDQIANHV
Mb2524c|M.bovis_AF2122/97 -ADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHL
Rv2496c|M.tuberculosis_H37Rv -ADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHL
MUL_3774|M.ulcerans_Agy99 -EHRCFDTPLAESALIGIAVGLALRGFVPVPEIQFDDFSYPAFDQVVSHL
MSMEG_4711|M.smegmatis_MC2_155 -AERCFDTPLAESAIIGIAVGFAIRGFVPVPEIQFDGFSYPAFDQIASHL
MAB_0896c|M.abscessus_ATCC_199 -ANRCFDTPLAESGIIGFAVGMAMGGFRPVVEMQFDAFAYPAFEQVVSHV
Mflv_3923|M.gilvum_PYR-GCK FPDRFFDVGIAEQHAMTSAAGLAMGGMHPVVALYST-FLNRAFDQMLMDV
MLBr_01038|M.leprae_Br4923 FPDRLFDVGIAEQHAMTSAAGLAMGRMHPVVAIYST-FLNRAFDQIMMDV
.* *. ::* : . * :: : *: : * . :
MMAR_3322|M.marinum_M SKFKDFSGGRWNVPMVLRAGVGGWYADGGEHEQTLWGTLASYPSTEVVVP
Mvan_0912|M.vanbaalenii_PYR-1 AKIHFFSGGNVRVPMVLTTAVGGGYSDGGQHSQCLWGTFAHLPGMKVVVP
MAV_2948|M.avium_104 AKLRFMTAGRTSAPLTVRTQVYAGLSTGATHSQSLEAWFMHIPGLKVIVP
TH_4167|M.thermoresistible__bu AKVRYMSGGRRGAPLVIRTMV--GTAAGAQHSQALEAWAMHTPGLKVVWP
Mb2524c|M.bovis_AF2122/97 AKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKVVVP
Rv2496c|M.tuberculosis_H37Rv AKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKVVVP
MUL_3774|M.ulcerans_Agy99 AKYRTRTRGEVNMAVTVRIPSFGGIGAAEHHLDATESYWAHTAGLKVVVP
MSMEG_4711|M.smegmatis_MC2_155 AKYRMRTHGDIDMPVTVRIPSFGGIGAVEHHSESTETYWLHTAGLKVVVP
MAB_0896c|M.abscessus_ATCC_199 AKLRNRTRGVLSVPMVIRVPYAGGIGGVEHHCDSSEAYYAHTPGLKVVTP
Mflv_3923|M.gilvum_PYR-GCK ALHKLP------VTMVLDRSGITGPDGASHNGMWDLSILGIVPGMRVAAP
MLBr_01038|M.leprae_Br4923 ALHKLP------VTMVIDRAGITGSDGPSHNGMWDLSMLGIVPGMRVAAP
: : .:.: : .. .* *
MMAR_3322|M.marinum_M STPADAAGLMLSAVRSDEFTVFLTPKLLDQQILDYLGGDQRSTVDLTGVQ
Mvan_0912|M.vanbaalenii_PYR-1 SSPADAKGMMIAAIRDDNPVVYMF---------------HKGIMGLSWMS
MAV_2948|M.avium_104 ATPRDGKGLLSSAIFDPDPCLFIETIRLQ---------------------
TH_4167|M.thermoresistible__bu STAADAAGLLNACLREDDPCLFIESMKLYYG-------------------
Mb2524c|M.bovis_AF2122/97 STPGDAYWLLRHAIACPDPVMYLEPKRRYH--------------------
Rv2496c|M.tuberculosis_H37Rv STPGDAYWLLRHAIACPDPVMYLEPKRRYH--------------------
MUL_3774|M.ulcerans_Agy99 STPGDAYWLLRHAIACPDPVMYLEPKRRYQ--------------------
MSMEG_4711|M.smegmatis_MC2_155 STPSDAYWLLRESISSPDPVIYLEPKRRYW--------------------
MAB_0896c|M.abscessus_ATCC_199 ATVADAYGLLREAIDDPDPVVFLEPKRLYF--------------------
Mflv_3923|M.gilvum_PYR-GCK RDGARLREELAEAVEVKDGPTAVRFPKGDVG-------------------
MLBr_01038|M.leprae_Br4923 RDAIRLREELGEALDVDDGPTAIRFPKGDVC-------------------
: .: : :
MMAR_3322|M.marinum_M PAAGVRGEVPDRV-EPIPFGQAAIRRDGGDLTLVSVGVGVHRCLEAAERL
Mvan_0912|M.vanbaalenii_PYR-1 KTSRALGPVPREP-YETPLGKANVVRPGRDISIVTLSLSVHHALDVADEL
MAV_2948|M.avium_104 ---GKKGLVPVEPGFRIPLGQADIKRPGTDVSLIGYGRPVHDALAAAAML
TH_4167|M.thermoresistible__bu ---GGKGPVPVAD-YVIPLGQADVKRVGSDVTICTYGVLVHAALEAAKTL
Mb2524c|M.bovis_AF2122/97 ----SRGMVDTSR-PEPPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTA
Rv2496c|M.tuberculosis_H37Rv ----GRGMVDTSR-PEPPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTA
MUL_3774|M.ulcerans_Agy99 ----VRGPVDTSR-PEPAIGQAMIRRAGADVTVITYGNLVSTALSAAEDA
MSMEG_4711|M.smegmatis_MC2_155 ----AREAVDTTT-PALPIGRAAVRRNGSDVTVITYGGLVATALSAAELA
MAB_0896c|M.abscessus_ATCC_199 ----SRADVELGR--GAKIGEAQVLRAGTDVTLIAYGPSVEPALQAAAAA
Mflv_3923|M.gilvum_PYR-GCK -----EDIPAIERRDGVDVLAVPADGLSDDVLIIAVGAFAAMSVAVAERL
MLBr_01038|M.leprae_Br4923 -----EDIPALKRRSGVDVLAVPATGLAQDVLLVGVGVFASMALAVAKRL
. . . *: : . . .: *
MMAR_3322|M.marinum_M SAD-GIEATVLDLRTLAPLDKEAIVEHVSRTGRVVVADEDYVRGGLTGEV
Mvan_0912|M.vanbaalenii_PYR-1 AKD-GIDCEVVDLRSLVPLDTDTILESVGKTGRLLVVDEDYESFGLSGEI
MAV_2948|M.avium_104 GDQ-GVSAEVVDLRTLVPLDVDTVVASVRRTRRAVIVHDAVQFAGPGAEV
TH_4167|M.thermoresistible__bu AGE-GVSVEVVDLRTLVPLDLQTVLDSVRKTKRLVVAHESVGFCGPGAEI
Mb2524c|M.bovis_AF2122/97 EQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGL
Rv2496c|M.tuberculosis_H37Rv EQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGL
MUL_3774|M.ulcerans_Agy99 AHQQGWSLEVIDLRSLIPLDFETIAASIRRTGRCVVLHEGPRSLGYGAGL
MSMEG_4711|M.smegmatis_MC2_155 EDR-GWSMEVVDLRSLNPLDFDTVADSVRRTGRAVVMHEGPRTLGFGAEL
MAB_0896c|M.abscessus_ATCC_199 ADE-GRDIEVVDLRSIAPFDDQSVTASVRKTGRCVIVQEAQGFGGVGAEI
Mflv_3923|M.gilvum_PYR-GCK RDQ-GIGVTVVDPRWVLPVP-AAINTLAAAHKLVVTVEDNGGHGGVGSAV
MLBr_01038|M.leprae_Br4923 HNQ-GIGVTVIDPRWVLPVC-DGVLELAHTHKLIVTLEDNGVNGGVGAAV
. *:* * : *. : : .: * . :
MMAR_3322|M.marinum_M AALLLEAGTS---ARYARVAV-EQTIPFAPHLEYAVLPNAERIIAAAKSL
Mvan_0912|M.vanbaalenii_PYR-1 IARVAERDPSVFKVAPSRVCVPDGSIPYARPLEMAVLPTPERIRAAIIEM
MAV_2948|M.avium_104 AAILHSRLFSELAAPVERVAARFVPNPAAAALEAQVYPSPERIAAAALKT
TH_4167|M.thermoresistible__bu AAAVGTELFAELAAPIQRVAGTYTPVPRAATLEAACRPDATKLSDAVRRI
Mb2524c|M.bovis_AF2122/97 AARIQEEMFYQLEAPVLRACGFDTPYP-PARLEKLWLPGPDRLLDCVERV
Rv2496c|M.tuberculosis_H37Rv AARIQEEMFYQLEAPVLRACGFDTPYP-PARLEKLWLPGPDRLLDCVERV
MUL_3774|M.ulcerans_Agy99 AARIQEELFYELEAPVLRACGFDTPYP-PARLERLWLPGPDRLLDCVERV
MSMEG_4711|M.smegmatis_MC2_155 AARISEELFYDLEAPVLRATGFDTPYP-PARLEKLWLPGVDRLLDCVERA
MAB_0896c|M.abscessus_ATCC_199 AARIQERCFHHLAAPVLRVSGYDIPYP-APRLERWYLPSTDRILDAVDRL
Mflv_3923|M.gilvum_PYR-GCK SAALRRAEIDVPCRDAALPQAFFDHASRGEVLAEVGLTERTIARQITGWV
MLBr_01038|M.leprae_Br4923 STALRQVEIDTPCRDVGLPQEFYDHASRSEVLADLGLTDQDVARRITGWV
: : . * .
MMAR_3322|M.marinum_M A----------------------
Mvan_0912|M.vanbaalenii_PYR-1 LRK--------------------
MAV_2948|M.avium_104 LGRTLTGATAHG-----------
TH_4167|M.thermoresistible__bu M----------------------
Mb2524c|M.bovis_AF2122/97 LRQP-------------------
Rv2496c|M.tuberculosis_H37Rv LRQP-------------------
MUL_3774|M.ulcerans_Agy99 LGQP-------------------
MSMEG_4711|M.smegmatis_MC2_155 MEQP-------------------
MAB_0896c|M.abscessus_ATCC_199 QWDDHPDSRWVVSA---------
Mflv_3923|M.gilvum_PYR-GCK AALG-----ATAGDRQVSESVD-
MLBr_01038|M.leprae_Br4923 VAFGHCGSGDDAGQYGPRSSQTM