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M. marinum M MMAR_3439 (-)

annotation: hydroxylase
coordinates: 4242788 - 4244314
length: 508

VVDVAADVVISGAGPNGLMLACELALAGIRPVVLDKLSGPSAEPKANGLVGQVVRMLDMRGLYQSFSGDD
GPPQPAQGWMFAAMPLSFLGLNDNSLYTMLMPQPRLVRLLEQRASALGVDLRWGDELTGFRCDSQSVVAE
VSSPQRSYEISSRYLIGADGGRSLVRKTLGIEFPGCTSATVGRLAHVQLPDEFRTADRAVEIPEFGRLPF
GHSRFDRGGVIFAEFEPGRSMLGTIEFGPPVEERPMSLAELRESVQRVLGVDIPLKRPKGPGPHALRRIN
GQNTRHAERYRRGRVLLLGDAAHVHSPMGGPGLNLGLQDTFNLGWKLAAELNGWAPDGLLDTYESERHPV
GARVMMHSLAQTALMAPGPEVGALRELFGELLTIPEVTKQMGALLAGSDLIYPVGDEHPLSGRLVPVLTT
DDGRRIDELMCGARPLLIDLADGDAAAAAQGWADRVEIVHTSIADRPAAAMLIRPDGYVAWAANAFDTGA
RGSLRDALQRWFGSHLGG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_3439--100% (508)hydroxylase
M. marinum MMMAR_4271-6e-7237.45% (510) hypothetical protein MMAR_4271
M. marinum MMMAR_3384-8e-3227.70% (556) hydroxylase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1780-1e-0925.83% (333) hypothetical protein Mb1780
M. gilvum PYR-GCKMflv_5009-3e-4230.06% (539) monooxygenase, FAD-binding
M. tuberculosis H37RvRv1751-8e-1026.19% (336) hypothetical protein Rv1751
M. leprae Br4923MLBr_02276-1e-0723.88% (356) putative FAD-linked oxidoreductase
M. abscessus ATCC 19977MAB_3483-9e-7937.67% (515) hypothetical protein MAB_3483
M. avium 104MAV_2736-5e-7236.63% (516) hypothetical protein MAV_2736
M. smegmatis MC2 155MSMEG_1649-1e-16857.54% (504) FAD dependent oxidoreductase
M. thermoresistible (build 8)TH_1880-9e-7537.97% (503) flavin-type hydroxylase
M. ulcerans Agy99MUL_0663-8e-0924.61% (386) FAD-linked oxidoreductase
M. vanbaalenii PYR-1Mvan_2422-8e-7737.84% (518) hypothetical protein Mvan_2422

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3439|M.marinum_M               -----------------------------------------------MVD
MSMEG_1649|M.smegmatis_MC2_155      ----------------------------------------------MNSS
MAV_2736|M.avium_104                ---------------MRGVRFSE-----------------RSVRG-----
Mvan_2422|M.vanbaalenii_PYR-1       ---------------MTTTRHKDTHKDTREDTREDTRDDSRDDGGDPNGD
MAB_3483|M.abscessus_ATCC_1997      ---------------MT---------------------------------
TH_1880|M.thermoresistible__bu      --------------------------------------------------
Mflv_5009|M.gilvum_PYR-GCK          ----------------------------------------------MPGA
MLBr_02276|M.leprae_Br4923          ------------------------------------------MRVETS--
MUL_0663|M.ulcerans_Agy99           ------------------------------------------METRVPRA
Mb1780|M.bovis_AF2122/97            MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv         MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
                                                                                      

MMAR_3439|M.marinum_M               VAADVVISGAGPNGLMLACELALAGIRPVVLDKLSGPSAE-PKANGLVGQ
MSMEG_1649|M.smegmatis_MC2_155      THTDVVIVGAGPNGLLLAGELALAGVRPVVLERLPQPSPE-LKANGIVGQ
MAV_2736|M.avium_104                --HAVLVAGAGPTGLMLAGELGLAGVDVALVERRADQQLIGSRAGGLHAR
Mvan_2422|M.vanbaalenii_PYR-1       TDHAVVVGGGGPTGMMTAAELALAGVDVAVVERRTTPEITGSRAGGLLSR
MAB_3483|M.abscessus_ATCC_1997      -EHAVVIAGGGPTGLMLAGELALAGADVAIVERRTTHELDGSRAAGMTSR
TH_1880|M.thermoresistible__bu      -VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPPAH-VRSLGLHVR
Mflv_5009|M.gilvum_PYR-GCK          HRSDVVVVGAGPTGLTLACCLRLHGVSVRVLDAAAGPATT-SRANFLHAR
MLBr_02276|M.leprae_Br4923          --ADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRDK-ACGDGLTPR
MUL_0663|M.ulcerans_Agy99           LGADLVVVGAGPAGSAAAAWAARAGRDVLVIDSAGFPRDK-ACGDGLTPR
Mb1780|M.bovis_AF2122/97            ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRD-FRGDTVHPT
Rv1751|M.tuberculosis_H37Rv         ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRD-FRGDTVHPT
                                          : *.** *   .      *    :::           .  :   

MMAR_3439|M.marinum_M               VVRMLDMRGLYQSFSGDDGPPQPAQGWM----FAAMPLSFLGLNDNSLYT
MSMEG_1649|M.smegmatis_MC2_155      VHRILDMRGLYQLLTGSSAPPQPLDGYI----FAGMRVPFTGVDDNPMYG
MAV_2736|M.avium_104                TLEILDQRGIVDRFLA-EGQVAQVAG------FAQIRLDISDFPTRHPYG
Mvan_2422|M.vanbaalenii_PYR-1       TLEILDQRGVVDRFLS-AGETMQVHG------FAQVRLDVSDLPTRHPYG
MAB_3483|M.abscessus_ATCC_1997      TLEVLDQRGILDRFTP-QGFSAPVAH------FSALLLDMTDQPTRHTFG
TH_1880|M.thermoresistible__bu      SIEMLDQRGLLDRFLA-HGQRHPVGGF-----FAAIAKPPAELDTAHGYV
Mflv_5009|M.gilvum_PYR-GCK          GSEVLDRMGALGTLPQESLRALRITNYLGDRPLATLEFGDPGMRTAAPP-
MLBr_02276|M.leprae_Br4923          AVAELKRLGLDDWLNTRIRHRGLRMSG-----FGGEVEVDWPGPSFPSTS
MUL_0663|M.ulcerans_Agy99           AIAELQQLGLGEWLAGRIQHRGLRMSG-----FGGEVEIGWPGPSFPAYS
Mb1780|M.bovis_AF2122/97            TMRLLDELGLWERFAALPYSEVRTATLHSNG-RAVTYIDFERLHQPYPYV
Rv1751|M.tuberculosis_H37Rv         TMRLLDELGLWERFAALPYSEVRTATLHSNG-RAVTYIDFERLHQPYPYV
                                        *.  *    :                   .                

MMAR_3439|M.marinum_M               MLMPQPRLVRLLEQRASAL-GVDLRWGDELTGFRCDSQSVV-AEVSSPQR
MSMEG_1649|M.smegmatis_MC2_155      MFIKQPQVVRQLADWVRDL-GVEIRWGHGLADMAPRPDGVT-LNVTSPTG
MAV_2736|M.avium_104                LALWQNHIERILADWVGEL-GVPIYRGHRIATCTQDDTGVD-VVASD---
Mvan_2422|M.vanbaalenii_PYR-1       LALWQKHIERILAEWVDEL-AVPVYRGREVVGVRQDGAGVD-IELSD---
MAB_3483|M.abscessus_ATCC_1997      LALLQYRIERTLSEWVGEH-GVPIYRGREVTGFTSSDDAVR-VELSD---
TH_1880|M.thermoresistible__bu      LGIRQPVTDRLLAEWAAER-GAVIRRGCAVVGLDQDAAGIT-VELAD---
Mflv_5009|M.gilvum_PYR-GCK          MVVSQAKVEAALRARLADL-DVEPEWGRKVIDVREDADGVV-ADLAD---
MLBr_02276|M.leprae_Br4923          SAVPRLELDDRIRKVAENS-GARMLLGTKAVSVYHDSSRRA-ASVTLAD-
MUL_0663|M.ulcerans_Agy99           SAVARLELDDRIRKVAEES-GARMLLGTKAVAAHHDSSRRV-VSLTLAD-
Mb1780|M.bovis_AF2122/97            AMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLREGGKVTGVRYQGAEG
Rv1751|M.tuberculosis_H37Rv         AMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLREGGKVTGVRYQGAEG
                                      : :      :                                      

MMAR_3439|M.marinum_M               SYEISSRYLIGADGGRSLVRKTLGIEFPGCTSATVGRLAHVQLPDEFRTA
MSMEG_1649|M.smegmatis_MC2_155      NHRLHATYLVGADGGRSTVRKAMGVGFPGVTSPVVARVAHVSIPDRLRGS
MAV_2736|M.avium_104                GRTLRGQYLVGCDGGRSVIRKAAGIDFPGWEATTSYLLAEAEMDWRT---
Mvan_2422|M.vanbaalenii_PYR-1       GRVLRAGYLVGCDGGRSLIRKSAGIEFPGWEPTTSYLLAEVEIAPED---
MAB_3483|M.abscessus_ATCC_1997      GSTLRAQYLVGCDGGRSLTRKIAGIDFPGWDPSTSCLVADVQMT------
TH_1880|M.thermoresistible__bu      GSVQRARYLVGCDGGRSTVRKLAGIGFPGEPARSETLLGEMSLSADP---
Mflv_5009|M.gilvum_PYR-GCK          GARVRGQWLVGCDGTTSVVRRQTGIEFPGVRLSERFLLADIHLDWAVDR-
MLBr_02276|M.leprae_Br4923          GTEVGCRQLIIADGARSPLGRKLGRSWHQKTVYGVAARGYLTTPRSDDL-
MUL_0663|M.ulcerans_Agy99           RTEVACRQLIVADGARSSLGRKLGRRWHQETVYGVAARGYLTTARSEDP-
Mb1780|M.bovis_AF2122/97            PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPREGD----
Rv1751|M.tuberculosis_H37Rv         PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPREGD----
                                             : .**  *   :  *                          

MMAR_3439|M.marinum_M               DRAVEIPEFGRLPFGHSRFDRGGVIFAEFEPGRSMLGTIEFGP--PVEER
MSMEG_1649|M.smegmatis_MC2_155      G-ALEVPGFGRIPFGHNRFDHGVFMYMEFEPGRPLVGTLEYGALLPADAP
MAV_2736|M.avium_104                ---GQPPQWG--IHHDSLGVHALSETEPAGGVRVLVTERQLR-----SAA
Mvan_2422|M.vanbaalenii_PYR-1       ---GREPEWG--IRRDALGVHALSRSD-DGPVRIMVTEQDLR-----RSG
MAB_3483|M.abscessus_ATCC_1997      ----EEPEWG--IHRQG-ALHSIFKFEEDGPVRVLVTEAQLG-----RRE
TH_1880|M.thermoresistible__bu      ---ATVAAVV--AEVRKTQLRFGAMPLGDGVYRVIVPAEGVAG----DRA
Mflv_5009|M.gilvum_PYR-GCK          ----AGTTGWIHPDGVVGAMPMPSTDGRDDLWRLFVYDPSLDR---KPTD
MLBr_02276|M.leprae_Br4923          --WLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSK----RPA
MUL_0663|M.ulcerans_Agy99           --WLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGGLSTTK----RPA
Mb1780|M.bovis_AF2122/97            ---AEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRE----RGI
Rv1751|M.tuberculosis_H37Rv         ---AEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRE----RGI
                                                                                      

MMAR_3439|M.marinum_M               PMSLAELRESVQRVLGVDIPLKRPKGPGPHALRRINGQNTRHAERYRRGR
MSMEG_1649|M.smegmatis_MC2_155      AVTVDELRDSVTRILGVEVPIGPPSGPGPHALRRINGQNTRQAEQYRVGN
MAV_2736|M.avium_104                EPNLDDLRQALIAVYRTDYGIHSPR-----WISRFT-DAARQAARYRDRR
Mvan_2422|M.vanbaalenii_PYR-1       VPDLAELREALVTVYGTDFGIHSPT-----SISRFT-DTARQAVAYRSGR
MAB_3483|M.abscessus_ATCC_1997      EPTLRDLSEALLSARGTDYGIHSPT-----WISRFT-DVTRQAATYRKGR
TH_1880|M.thermoresistible__bu      EPTLDEFRRRLKAFAGTDFGAHTPR-----WLSRFG-DATRLAERYRAGR
Mflv_5009|M.gilvum_PYR-GCK          SEILDRISELVPYRTGRRVKIGDAE-----WLSMFT-VHRRLADTYRRGR
MLBr_02276|M.leprae_Br4923          DLALRSLISYYTDLRRHEWGFSGQP----RAVSSALLPMGGAVSGVAGPN
MUL_0663|M.ulcerans_Agy99           DLALRPLMSYYTDLRRDEWGFTGQP----RAVASALLPMGGAVSGVAGPN
Mb1780|M.bovis_AF2122/97            EEFRRDVSELLPEATASVAALASTD-----EVKHLNVKVNRLRRWHIDG-
Rv1751|M.tuberculosis_H37Rv         EEFRRDVSELLPEATASVAALASMD-----EVKHLNVKVNRLRRWHIDG-
                                          .                        :                  

MMAR_3439|M.marinum_M               VLLLGDAAHVHSPMGGPGLNLGLQDTFNLGWKLAAELNGWAPDGLLDTYE
MSMEG_1649|M.smegmatis_MC2_155      VFLIGDAAHVHSAVGGPGLNLGMQDATNLGWKLAAAVHGWAPSGLLDTYH
MAV_2736|M.avium_104                VLLAGDAAHIHHPVGGQGLNTGVQDAVNLGWKLALVVGGASPPALLDTYH
Mvan_2422|M.vanbaalenii_PYR-1       ILLVGDAAHVHHPVGGQGLNTGMQDAVNLGWKLAQVVQGWSPDTLLDTYH
MAB_3483|M.abscessus_ATCC_1997      VLLAGDAAHVHFPIGGQGLNTGMQDAVNLGWKLAQVVNGTSPENLLDTYH
TH_1880|M.thermoresistible__bu      VFLAGDAAHVHPPAGGQGLNLGIQDAFNLGWKLAAAVGGWAPDGLLDTYH
Mflv_5009|M.gilvum_PYR-GCK          VLIAGDAAHVHAPFGGQGMLTGIGDAENVGFKLALVVRGLAADDLLDTYE
MLBr_02276|M.leprae_Br4923          WMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDLRDLSYVWPSLLQQHY
MUL_0663|M.ulcerans_Agy99           WMLIGDAAACVNPLNGEGIDYGLDTGRLAAELLDSPDLSQLWPSLLQAHY
Mb1780|M.bovis_AF2122/97            LLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAV
Rv1751|M.tuberculosis_H37Rv         LLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAV
                                     :  ****    .  * *:  .:      .  *                 

MMAR_3439|M.marinum_M               SERHPVGARVMMHSLAQTALMAPG-PEVGALRELFG-ELLTIPEVTKQMG
MSMEG_1649|M.smegmatis_MC2_155      GERHPAGERVLMQSMAQTALLAGG-PEVGALRTLFG-ELLATTDGAEHIA
MAV_2736|M.avium_104                AERHPVGERVLRNAIAQMALLRPD-ERTRALRDLVT-ELLGMDEPRKRFA
Mvan_2422|M.vanbaalenii_PYR-1       DERQPVGARVLRNAVAQMALLRPD-DRTTVLHGVVS-DMLDMDEPRRRFA
MAB_3483|M.abscessus_ATCC_1997      AERHPVAARVLHNTMAQTALIRPG-ERVDALRDIMS-DLLTLDMPRRRIA
TH_1880|M.thermoresistible__bu      AERHPVAADVLNNTRAQMELMSPE-PGPRAVRWLLA-ELMDFEEVNRYLT
Mflv_5009|M.gilvum_PYR-GCK          AERRPLATQVLRGTSAITRVNVAGNPIVRFLRDRVAPRVFGLPAVQRWTT
MLBr_02276|M.leprae_Br4923          GRGFSVARRLALLLTFKRCLPAIG------------------PSAMRSTS
MUL_0663|M.ulcerans_Agy99           GRGFSVARRLALLLTYQRFLPTTG------------------PVAMRSTA
Mb1780|M.bovis_AF2122/97            RRRRAFPTAVTQAVQRVLHRRLLG---------------PLLQGRDPTPP
Rv1751|M.tuberculosis_H37Rv         RRRRAFPTAVTQAVQRVLHRRLLG---------------PLLQGRDPTPP
                                     .  .    :                                        

MMAR_3439|M.marinum_M               ALLAGSDLIYP-----VGDEHPLSGRLVPVLTTDDG----RRIDELMCGA
MSMEG_1649|M.smegmatis_MC2_155      HVLAGADVRYD-----VGDGHPLSGRLVPEVVFDDG----RRLADLMRAA
MAV_2736|M.avium_104                AMISGLDVRYD-----LGPGHPLLGRRMPDLDLVTAD-GASRVFALLRNA
Mvan_2422|M.vanbaalenii_PYR-1       AMMSGLDIHYD-----LGDGHPLLGLRMPDLDLETAH-GPTRVSALLRQA
MAB_3483|M.abscessus_ATCC_1997      AMMSGLDIHYD-----LGPGHPLLGRRMPDLEVRTAQ-GPRCVFTLLREG
TH_1880|M.thermoresistible__bu      EKITAIGVRYHT----MGDGHGLLGRRMRDIPLTGG-----RLYARMHAG
Mflv_5009|M.gilvum_PYR-GCK          YTASQLWVSYRNGPLGGRGSKPRPGDRIDDAPCSRPDGTATRLHGELGGR
MLBr_02276|M.leprae_Br4923          LITIAVRVMAN-------------------LVTDDDA-------------
MUL_0663|M.ulcerans_Agy99           LMKVAMRVMAN-------------------LVTEEDS-------------
Mb1780|M.bovis_AF2122/97            AALLGLVERLP---------------------------------------
Rv1751|M.tuberculosis_H37Rv         AALLGLVERLP---------------------------------------
                                                                                      

MMAR_3439|M.marinum_M               RPLLIDLADGDA-AAAAQGWADRVEIVHTS-------------IADRPAA
MSMEG_1649|M.smegmatis_MC2_155      RPVLLDLDGGAY-AAAAIDWRDRVDVITAA-------------AAERPAP
MAV_2736|M.avium_104                RPVLLNFAGAG--RRSVAGWADRVRVVDAK---CVADWELPVLGRVSAPP
Mvan_2422|M.vanbaalenii_PYR-1       RPVLLDLGAPD--AVDLTGWEARVRMVRAN---AATVWELPVIGEVPAPA
MAB_3483|M.abscessus_ATCC_1997      RGVLLNLGTP---ITGASGWSHRVDVVEAEYLDAEGTFELPVIGMVEAPH
TH_1880|M.thermoresistible__bu      RGVLLDRTGT----LSVSGWADRVDHIVDP-------------GAALDVP
Mflv_5009|M.gilvum_PYR-GCK          WALLLPRGVPAVGAAAVRGPAGYLADHVVT-------------LHHDRDD
MLBr_02276|M.leprae_Br4923          ------------------DWVARVWRSGGW-----------------ASW
MUL_0663|M.ulcerans_Agy99           ------------------DWVARLWRGGGR-----------------ASR
Mb1780|M.bovis_AF2122/97            -------------------WLSAVPAYFVG--------------------
Rv1751|M.tuberculosis_H37Rv         -------------------WLSAVPAYFVG--------------------
                                                           :                          

MMAR_3439|M.marinum_M               AMLIRPDGYVAWAANAFDTGARGSLRDALQRWFGSHLGG----
MSMEG_1649|M.smegmatis_MC2_155      ALLIRPDGYLAWAATGSGADEHQRMRRALGRWFGEAHAGLAHA
MAV_2736|M.avium_104                AVLIRPDGHVAWAGDPN----DPGLHDALTTWCGPP--AAGG-
Mvan_2422|M.vanbaalenii_PYR-1       AVLIRPDGHVAWVAGDS----AAAPAEAAARWFGAP--TGRR-
MAB_3483|M.abscessus_ATCC_1997      AVLIRPDGYVAWVGNGT----TAGLNGALQRWFGPPRYSGGGS
TH_1880|M.thermoresistible__bu      AVLLRPDGHVAWVGADHPG--QQDLTARLSRWFGAPA------
Mflv_5009|M.gilvum_PYR-GCK          VMLVRPDAHLAWRGAHDDP-------TGLDRWLATALHPGGTQ
MLBr_02276|M.leprae_Br4923          LVDRRPPFS----------------------------------
MUL_0663|M.ulcerans_Agy99           LIDRRPPFH----------------------------------
Mb1780|M.bovis_AF2122/97            -VGVRPEHAPAFARRGP------------GNRKGP--------
Rv1751|M.tuberculosis_H37Rv         -VGVRPEHAPAFARRGP------------GNRKGP--------
                                     :  **