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VVDVAADVVISGAGPNGLMLACELALAGIRPVVLDKLSGPSAEPKANGLVGQVVRMLDMRGLYQSFSGDD GPPQPAQGWMFAAMPLSFLGLNDNSLYTMLMPQPRLVRLLEQRASALGVDLRWGDELTGFRCDSQSVVAE VSSPQRSYEISSRYLIGADGGRSLVRKTLGIEFPGCTSATVGRLAHVQLPDEFRTADRAVEIPEFGRLPF GHSRFDRGGVIFAEFEPGRSMLGTIEFGPPVEERPMSLAELRESVQRVLGVDIPLKRPKGPGPHALRRIN GQNTRHAERYRRGRVLLLGDAAHVHSPMGGPGLNLGLQDTFNLGWKLAAELNGWAPDGLLDTYESERHPV GARVMMHSLAQTALMAPGPEVGALRELFGELLTIPEVTKQMGALLAGSDLIYPVGDEHPLSGRLVPVLTT DDGRRIDELMCGARPLLIDLADGDAAAAAQGWADRVEIVHTSIADRPAAAMLIRPDGYVAWAANAFDTGA RGSLRDALQRWFGSHLGG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3439 | - | - | 100% (508) | hydroxylase |
M. marinum M | MMAR_4271 | - | 6e-72 | 37.45% (510) | hypothetical protein MMAR_4271 |
M. marinum M | MMAR_3384 | - | 8e-32 | 27.70% (556) | hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1780 | - | 1e-09 | 25.83% (333) | hypothetical protein Mb1780 |
M. gilvum PYR-GCK | Mflv_5009 | - | 3e-42 | 30.06% (539) | monooxygenase, FAD-binding |
M. tuberculosis H37Rv | Rv1751 | - | 8e-10 | 26.19% (336) | hypothetical protein Rv1751 |
M. leprae Br4923 | MLBr_02276 | - | 1e-07 | 23.88% (356) | putative FAD-linked oxidoreductase |
M. abscessus ATCC 19977 | MAB_3483 | - | 9e-79 | 37.67% (515) | hypothetical protein MAB_3483 |
M. avium 104 | MAV_2736 | - | 5e-72 | 36.63% (516) | hypothetical protein MAV_2736 |
M. smegmatis MC2 155 | MSMEG_1649 | - | 1e-168 | 57.54% (504) | FAD dependent oxidoreductase |
M. thermoresistible (build 8) | TH_1880 | - | 9e-75 | 37.97% (503) | flavin-type hydroxylase |
M. ulcerans Agy99 | MUL_0663 | - | 8e-09 | 24.61% (386) | FAD-linked oxidoreductase |
M. vanbaalenii PYR-1 | Mvan_2422 | - | 8e-77 | 37.84% (518) | hypothetical protein Mvan_2422 |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_3439|M.marinum_M -----------------------------------------------MVD MSMEG_1649|M.smegmatis_MC2_155 ----------------------------------------------MNSS MAV_2736|M.avium_104 ---------------MRGVRFSE-----------------RSVRG----- Mvan_2422|M.vanbaalenii_PYR-1 ---------------MTTTRHKDTHKDTREDTREDTRDDSRDDGGDPNGD MAB_3483|M.abscessus_ATCC_1997 ---------------MT--------------------------------- TH_1880|M.thermoresistible__bu -------------------------------------------------- Mflv_5009|M.gilvum_PYR-GCK ----------------------------------------------MPGA MLBr_02276|M.leprae_Br4923 ------------------------------------------MRVETS-- MUL_0663|M.ulcerans_Agy99 ------------------------------------------METRVPRA Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG MMAR_3439|M.marinum_M VAADVVISGAGPNGLMLACELALAGIRPVVLDKLSGPSAE-PKANGLVGQ MSMEG_1649|M.smegmatis_MC2_155 THTDVVIVGAGPNGLLLAGELALAGVRPVVLERLPQPSPE-LKANGIVGQ MAV_2736|M.avium_104 --HAVLVAGAGPTGLMLAGELGLAGVDVALVERRADQQLIGSRAGGLHAR Mvan_2422|M.vanbaalenii_PYR-1 TDHAVVVGGGGPTGMMTAAELALAGVDVAVVERRTTPEITGSRAGGLLSR MAB_3483|M.abscessus_ATCC_1997 -EHAVVIAGGGPTGLMLAGELALAGADVAIVERRTTHELDGSRAAGMTSR TH_1880|M.thermoresistible__bu -VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPPAH-VRSLGLHVR Mflv_5009|M.gilvum_PYR-GCK HRSDVVVVGAGPTGLTLACCLRLHGVSVRVLDAAAGPATT-SRANFLHAR MLBr_02276|M.leprae_Br4923 --ADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRDK-ACGDGLTPR MUL_0663|M.ulcerans_Agy99 LGADLVVVGAGPAGSAAAAWAARAGRDVLVIDSAGFPRDK-ACGDGLTPR Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRD-FRGDTVHPT Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRD-FRGDTVHPT : *.** * . * ::: . : MMAR_3439|M.marinum_M VVRMLDMRGLYQSFSGDDGPPQPAQGWM----FAAMPLSFLGLNDNSLYT MSMEG_1649|M.smegmatis_MC2_155 VHRILDMRGLYQLLTGSSAPPQPLDGYI----FAGMRVPFTGVDDNPMYG MAV_2736|M.avium_104 TLEILDQRGIVDRFLA-EGQVAQVAG------FAQIRLDISDFPTRHPYG Mvan_2422|M.vanbaalenii_PYR-1 TLEILDQRGVVDRFLS-AGETMQVHG------FAQVRLDVSDLPTRHPYG MAB_3483|M.abscessus_ATCC_1997 TLEVLDQRGILDRFTP-QGFSAPVAH------FSALLLDMTDQPTRHTFG TH_1880|M.thermoresistible__bu SIEMLDQRGLLDRFLA-HGQRHPVGGF-----FAAIAKPPAELDTAHGYV Mflv_5009|M.gilvum_PYR-GCK GSEVLDRMGALGTLPQESLRALRITNYLGDRPLATLEFGDPGMRTAAPP- MLBr_02276|M.leprae_Br4923 AVAELKRLGLDDWLNTRIRHRGLRMSG-----FGGEVEVDWPGPSFPSTS MUL_0663|M.ulcerans_Agy99 AIAELQQLGLGEWLAGRIQHRGLRMSG-----FGGEVEIGWPGPSFPAYS Mb1780|M.bovis_AF2122/97 TMRLLDELGLWERFAALPYSEVRTATLHSNG-RAVTYIDFERLHQPYPYV Rv1751|M.tuberculosis_H37Rv TMRLLDELGLWERFAALPYSEVRTATLHSNG-RAVTYIDFERLHQPYPYV *. * : . MMAR_3439|M.marinum_M MLMPQPRLVRLLEQRASAL-GVDLRWGDELTGFRCDSQSVV-AEVSSPQR MSMEG_1649|M.smegmatis_MC2_155 MFIKQPQVVRQLADWVRDL-GVEIRWGHGLADMAPRPDGVT-LNVTSPTG MAV_2736|M.avium_104 LALWQNHIERILADWVGEL-GVPIYRGHRIATCTQDDTGVD-VVASD--- Mvan_2422|M.vanbaalenii_PYR-1 LALWQKHIERILAEWVDEL-AVPVYRGREVVGVRQDGAGVD-IELSD--- MAB_3483|M.abscessus_ATCC_1997 LALLQYRIERTLSEWVGEH-GVPIYRGREVTGFTSSDDAVR-VELSD--- TH_1880|M.thermoresistible__bu LGIRQPVTDRLLAEWAAER-GAVIRRGCAVVGLDQDAAGIT-VELAD--- Mflv_5009|M.gilvum_PYR-GCK MVVSQAKVEAALRARLADL-DVEPEWGRKVIDVREDADGVV-ADLAD--- MLBr_02276|M.leprae_Br4923 SAVPRLELDDRIRKVAENS-GARMLLGTKAVSVYHDSSRRA-ASVTLAD- MUL_0663|M.ulcerans_Agy99 SAVARLELDDRIRKVAEES-GARMLLGTKAVAAHHDSSRRV-VSLTLAD- Mb1780|M.bovis_AF2122/97 AMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLREGGKVTGVRYQGAEG Rv1751|M.tuberculosis_H37Rv AMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLREGGKVTGVRYQGAEG : : : MMAR_3439|M.marinum_M SYEISSRYLIGADGGRSLVRKTLGIEFPGCTSATVGRLAHVQLPDEFRTA MSMEG_1649|M.smegmatis_MC2_155 NHRLHATYLVGADGGRSTVRKAMGVGFPGVTSPVVARVAHVSIPDRLRGS MAV_2736|M.avium_104 GRTLRGQYLVGCDGGRSVIRKAAGIDFPGWEATTSYLLAEAEMDWRT--- Mvan_2422|M.vanbaalenii_PYR-1 GRVLRAGYLVGCDGGRSLIRKSAGIEFPGWEPTTSYLLAEVEIAPED--- MAB_3483|M.abscessus_ATCC_1997 GSTLRAQYLVGCDGGRSLTRKIAGIDFPGWDPSTSCLVADVQMT------ TH_1880|M.thermoresistible__bu GSVQRARYLVGCDGGRSTVRKLAGIGFPGEPARSETLLGEMSLSADP--- Mflv_5009|M.gilvum_PYR-GCK GARVRGQWLVGCDGTTSVVRRQTGIEFPGVRLSERFLLADIHLDWAVDR- MLBr_02276|M.leprae_Br4923 GTEVGCRQLIIADGARSPLGRKLGRSWHQKTVYGVAARGYLTTPRSDDL- MUL_0663|M.ulcerans_Agy99 RTEVACRQLIVADGARSSLGRKLGRRWHQETVYGVAARGYLTTARSEDP- Mb1780|M.bovis_AF2122/97 PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPREGD---- Rv1751|M.tuberculosis_H37Rv PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPREGD---- : .** * : * MMAR_3439|M.marinum_M DRAVEIPEFGRLPFGHSRFDRGGVIFAEFEPGRSMLGTIEFGP--PVEER MSMEG_1649|M.smegmatis_MC2_155 G-ALEVPGFGRIPFGHNRFDHGVFMYMEFEPGRPLVGTLEYGALLPADAP MAV_2736|M.avium_104 ---GQPPQWG--IHHDSLGVHALSETEPAGGVRVLVTERQLR-----SAA Mvan_2422|M.vanbaalenii_PYR-1 ---GREPEWG--IRRDALGVHALSRSD-DGPVRIMVTEQDLR-----RSG MAB_3483|M.abscessus_ATCC_1997 ----EEPEWG--IHRQG-ALHSIFKFEEDGPVRVLVTEAQLG-----RRE TH_1880|M.thermoresistible__bu ---ATVAAVV--AEVRKTQLRFGAMPLGDGVYRVIVPAEGVAG----DRA Mflv_5009|M.gilvum_PYR-GCK ----AGTTGWIHPDGVVGAMPMPSTDGRDDLWRLFVYDPSLDR---KPTD MLBr_02276|M.leprae_Br4923 --WLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSK----RPA MUL_0663|M.ulcerans_Agy99 --WLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGGLSTTK----RPA Mb1780|M.bovis_AF2122/97 ---AEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRE----RGI Rv1751|M.tuberculosis_H37Rv ---AEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRE----RGI MMAR_3439|M.marinum_M PMSLAELRESVQRVLGVDIPLKRPKGPGPHALRRINGQNTRHAERYRRGR MSMEG_1649|M.smegmatis_MC2_155 AVTVDELRDSVTRILGVEVPIGPPSGPGPHALRRINGQNTRQAEQYRVGN MAV_2736|M.avium_104 EPNLDDLRQALIAVYRTDYGIHSPR-----WISRFT-DAARQAARYRDRR Mvan_2422|M.vanbaalenii_PYR-1 VPDLAELREALVTVYGTDFGIHSPT-----SISRFT-DTARQAVAYRSGR MAB_3483|M.abscessus_ATCC_1997 EPTLRDLSEALLSARGTDYGIHSPT-----WISRFT-DVTRQAATYRKGR TH_1880|M.thermoresistible__bu EPTLDEFRRRLKAFAGTDFGAHTPR-----WLSRFG-DATRLAERYRAGR Mflv_5009|M.gilvum_PYR-GCK SEILDRISELVPYRTGRRVKIGDAE-----WLSMFT-VHRRLADTYRRGR MLBr_02276|M.leprae_Br4923 DLALRSLISYYTDLRRHEWGFSGQP----RAVSSALLPMGGAVSGVAGPN MUL_0663|M.ulcerans_Agy99 DLALRPLMSYYTDLRRDEWGFTGQP----RAVASALLPMGGAVSGVAGPN Mb1780|M.bovis_AF2122/97 EEFRRDVSELLPEATASVAALASTD-----EVKHLNVKVNRLRRWHIDG- Rv1751|M.tuberculosis_H37Rv EEFRRDVSELLPEATASVAALASMD-----EVKHLNVKVNRLRRWHIDG- . : MMAR_3439|M.marinum_M VLLLGDAAHVHSPMGGPGLNLGLQDTFNLGWKLAAELNGWAPDGLLDTYE MSMEG_1649|M.smegmatis_MC2_155 VFLIGDAAHVHSAVGGPGLNLGMQDATNLGWKLAAAVHGWAPSGLLDTYH MAV_2736|M.avium_104 VLLAGDAAHIHHPVGGQGLNTGVQDAVNLGWKLALVVGGASPPALLDTYH Mvan_2422|M.vanbaalenii_PYR-1 ILLVGDAAHVHHPVGGQGLNTGMQDAVNLGWKLAQVVQGWSPDTLLDTYH MAB_3483|M.abscessus_ATCC_1997 VLLAGDAAHVHFPIGGQGLNTGMQDAVNLGWKLAQVVNGTSPENLLDTYH TH_1880|M.thermoresistible__bu VFLAGDAAHVHPPAGGQGLNLGIQDAFNLGWKLAAAVGGWAPDGLLDTYH Mflv_5009|M.gilvum_PYR-GCK VLIAGDAAHVHAPFGGQGMLTGIGDAENVGFKLALVVRGLAADDLLDTYE MLBr_02276|M.leprae_Br4923 WMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDLRDLSYVWPSLLQQHY MUL_0663|M.ulcerans_Agy99 WMLIGDAAACVNPLNGEGIDYGLDTGRLAAELLDSPDLSQLWPSLLQAHY Mb1780|M.bovis_AF2122/97 LLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAV Rv1751|M.tuberculosis_H37Rv LLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAV : **** . * *: .: . * MMAR_3439|M.marinum_M SERHPVGARVMMHSLAQTALMAPG-PEVGALRELFG-ELLTIPEVTKQMG MSMEG_1649|M.smegmatis_MC2_155 GERHPAGERVLMQSMAQTALLAGG-PEVGALRTLFG-ELLATTDGAEHIA MAV_2736|M.avium_104 AERHPVGERVLRNAIAQMALLRPD-ERTRALRDLVT-ELLGMDEPRKRFA Mvan_2422|M.vanbaalenii_PYR-1 DERQPVGARVLRNAVAQMALLRPD-DRTTVLHGVVS-DMLDMDEPRRRFA MAB_3483|M.abscessus_ATCC_1997 AERHPVAARVLHNTMAQTALIRPG-ERVDALRDIMS-DLLTLDMPRRRIA TH_1880|M.thermoresistible__bu AERHPVAADVLNNTRAQMELMSPE-PGPRAVRWLLA-ELMDFEEVNRYLT Mflv_5009|M.gilvum_PYR-GCK AERRPLATQVLRGTSAITRVNVAGNPIVRFLRDRVAPRVFGLPAVQRWTT MLBr_02276|M.leprae_Br4923 GRGFSVARRLALLLTFKRCLPAIG------------------PSAMRSTS MUL_0663|M.ulcerans_Agy99 GRGFSVARRLALLLTYQRFLPTTG------------------PVAMRSTA Mb1780|M.bovis_AF2122/97 RRRRAFPTAVTQAVQRVLHRRLLG---------------PLLQGRDPTPP Rv1751|M.tuberculosis_H37Rv RRRRAFPTAVTQAVQRVLHRRLLG---------------PLLQGRDPTPP . . : MMAR_3439|M.marinum_M ALLAGSDLIYP-----VGDEHPLSGRLVPVLTTDDG----RRIDELMCGA MSMEG_1649|M.smegmatis_MC2_155 HVLAGADVRYD-----VGDGHPLSGRLVPEVVFDDG----RRLADLMRAA MAV_2736|M.avium_104 AMISGLDVRYD-----LGPGHPLLGRRMPDLDLVTAD-GASRVFALLRNA Mvan_2422|M.vanbaalenii_PYR-1 AMMSGLDIHYD-----LGDGHPLLGLRMPDLDLETAH-GPTRVSALLRQA MAB_3483|M.abscessus_ATCC_1997 AMMSGLDIHYD-----LGPGHPLLGRRMPDLEVRTAQ-GPRCVFTLLREG TH_1880|M.thermoresistible__bu EKITAIGVRYHT----MGDGHGLLGRRMRDIPLTGG-----RLYARMHAG Mflv_5009|M.gilvum_PYR-GCK YTASQLWVSYRNGPLGGRGSKPRPGDRIDDAPCSRPDGTATRLHGELGGR MLBr_02276|M.leprae_Br4923 LITIAVRVMAN-------------------LVTDDDA------------- MUL_0663|M.ulcerans_Agy99 LMKVAMRVMAN-------------------LVTEEDS------------- Mb1780|M.bovis_AF2122/97 AALLGLVERLP--------------------------------------- Rv1751|M.tuberculosis_H37Rv AALLGLVERLP--------------------------------------- MMAR_3439|M.marinum_M RPLLIDLADGDA-AAAAQGWADRVEIVHTS-------------IADRPAA MSMEG_1649|M.smegmatis_MC2_155 RPVLLDLDGGAY-AAAAIDWRDRVDVITAA-------------AAERPAP MAV_2736|M.avium_104 RPVLLNFAGAG--RRSVAGWADRVRVVDAK---CVADWELPVLGRVSAPP Mvan_2422|M.vanbaalenii_PYR-1 RPVLLDLGAPD--AVDLTGWEARVRMVRAN---AATVWELPVIGEVPAPA MAB_3483|M.abscessus_ATCC_1997 RGVLLNLGTP---ITGASGWSHRVDVVEAEYLDAEGTFELPVIGMVEAPH TH_1880|M.thermoresistible__bu RGVLLDRTGT----LSVSGWADRVDHIVDP-------------GAALDVP Mflv_5009|M.gilvum_PYR-GCK WALLLPRGVPAVGAAAVRGPAGYLADHVVT-------------LHHDRDD MLBr_02276|M.leprae_Br4923 ------------------DWVARVWRSGGW-----------------ASW MUL_0663|M.ulcerans_Agy99 ------------------DWVARLWRGGGR-----------------ASR Mb1780|M.bovis_AF2122/97 -------------------WLSAVPAYFVG-------------------- Rv1751|M.tuberculosis_H37Rv -------------------WLSAVPAYFVG-------------------- : MMAR_3439|M.marinum_M AMLIRPDGYVAWAANAFDTGARGSLRDALQRWFGSHLGG---- MSMEG_1649|M.smegmatis_MC2_155 ALLIRPDGYLAWAATGSGADEHQRMRRALGRWFGEAHAGLAHA MAV_2736|M.avium_104 AVLIRPDGHVAWAGDPN----DPGLHDALTTWCGPP--AAGG- Mvan_2422|M.vanbaalenii_PYR-1 AVLIRPDGHVAWVAGDS----AAAPAEAAARWFGAP--TGRR- MAB_3483|M.abscessus_ATCC_1997 AVLIRPDGYVAWVGNGT----TAGLNGALQRWFGPPRYSGGGS TH_1880|M.thermoresistible__bu AVLLRPDGHVAWVGADHPG--QQDLTARLSRWFGAPA------ Mflv_5009|M.gilvum_PYR-GCK VMLVRPDAHLAWRGAHDDP-------TGLDRWLATALHPGGTQ MLBr_02276|M.leprae_Br4923 LVDRRPPFS---------------------------------- MUL_0663|M.ulcerans_Agy99 LIDRRPPFH---------------------------------- Mb1780|M.bovis_AF2122/97 -VGVRPEHAPAFARRGP------------GNRKGP-------- Rv1751|M.tuberculosis_H37Rv -VGVRPEHAPAFARRGP------------GNRKGP-------- : **