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MNQQDSPSTCYRAEPVDAQAFTAHFDRLYTRLARPYDLAVKLLPVWRHWISAALPHIRGPRVLEVSFGTG WLLTRYANNFDTYGVDLNRRMVAMARRNLRRAGVSADLSQANVEALPYPDGQFDTVVNTMSFSGYPNGAR AMTQLHRVLRRQGRLVLIDVGYPQDGNRLGTALAGMWQRAGDVIRDMPTLLDDFGFEVQHEQIGGFGSVH LYLATKL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3393 | - | - | 100% (217) | methyltransferase |
| M. marinum M | MMAR_3170 | - | 1e-09 | 35.51% (107) | methyltransferase |
| M. marinum M | MMAR_1062 | - | 2e-08 | 33.56% (149) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1550 | - | 2e-08 | 32.14% (112) | methyltransferase |
| M. gilvum PYR-GCK | Mflv_4269 | - | 1e-08 | 32.86% (140) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1523 | - | 2e-08 | 32.14% (112) | methyltransferase |
| M. leprae Br4923 | MLBr_00130 | - | 2e-08 | 29.27% (123) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_4613 | - | 2e-11 | 33.79% (145) | similarity with UbiE/COQ5 methyltransferase |
| M. avium 104 | MAV_3373 | - | 3e-10 | 35.64% (101) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_0393 | - | 2e-09 | 34.87% (152) | Fmt protein |
| M. thermoresistible (build 8) | TH_2189 | - | 4e-08 | 32.35% (136) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2377 | - | 4e-09 | 34.58% (107) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2948 | - | 7e-17 | 35.33% (150) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1550|M.bovis_AF2122/97 --------------------------------------------------
Rv1523|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
MUL_2377|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0393|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK --------------------------------------------------
TH_2189|M.thermoresistible__bu VIRRLMATALTALTTAVLAGCGDAGSWVEAKPAEGWSAQYGDAANSSYTS
MMAR_3393|M.marinum_M --------------------------------------------------
Mvan_2948|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4613|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_3373|M.avium_104 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 --------------------------------------------------
Rv1523|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
MUL_2377|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0393|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK --------------------------------------------------
TH_2189|M.thermoresistible__bu AAGAEALTLEWSRSVKGELAAQVAVGASGYLAVNAQTPAGCSLMVWEYAN
MMAR_3393|M.marinum_M --------------------------------------------------
Mvan_2948|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4613|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_3373|M.avium_104 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 --------------------------------------------------
Rv1523|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
MUL_2377|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0393|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK --------------------------------------------------
TH_2189|M.thermoresistible__bu SARQRWCTRLVQGGGRTSPLLDGFDNVYIGQPGAILSFPPTQWIRWRKPV
MMAR_3393|M.marinum_M --------------------------------------------------
Mvan_2948|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4613|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_3373|M.avium_104 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 --------------------------------------------------
Rv1523|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
MUL_2377|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0393|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK --------------------------------------------------
TH_2189|M.thermoresistible__bu IGMPTTPRILAPGELLVVTHLGQVLLFDAHRGTVTGTPLDLVAGVDPTDS
MMAR_3393|M.marinum_M --------------------------------------------------
Mvan_2948|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4613|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_3373|M.avium_104 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 ----------------------MTITALTVTLPLLWRRLTTAGVKYADQG
Rv1523|M.tuberculosis_H37Rv ----------------------MTITALTVTLPLLWRRLTTAGVKYADQG
MLBr_00130|M.leprae_Br4923 -------------------------------------------MAFTRIH
MUL_2377|M.ulcerans_Agy99 -------------------------------------------MAFSPAH
MSMEG_0393|M.smegmatis_MC2_155 -------------------------------------------MEARDRV
Mflv_4269|M.gilvum_PYR-GCK ------------------------------------------MTETKEPG
TH_2189|M.thermoresistible__bu ERGLADCAGARXXXCWPPPRPPSTVTPRARDAARHPTARLPAMTETTEPG
MMAR_3393|M.marinum_M --------------------------------------------------
Mvan_2948|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4613|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_3373|M.avium_104 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 HFVGSAGVPAADAGGRDAASEQIARWTQTCTVVLVCGHGPAKWAFRSWCT
Rv1523|M.tuberculosis_H37Rv HFVGSAGVPAADAGGRDAASEQIARWTQTCTVVLVCGHGPAKWAFRSWCT
MLBr_00130|M.leprae_Br4923 SFLASAGN-----------------------------------------T
MUL_2377|M.ulcerans_Agy99 RLLARLGS-----------------------------------------T
MSMEG_0393|M.smegmatis_MC2_155 AWRL--NIK-----------------------------------------
Mflv_4269|M.gilvum_PYR-GCK AYPDVA--------------------------------------------
TH_2189|M.thermoresistible__bu IGSEGAGD------------------------------------------
MMAR_3393|M.marinum_M --------------------------------------------------
Mvan_2948|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4613|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_3373|M.avium_104 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 SRSCDTLPVALRYRLQSNPLVGKLTTKYFLPLGTRQVG-DHVVFFNFGYE
Rv1523|M.tuberculosis_H37Rv SRSCDTLPVALRYRLQSNPLVGKLTTKYFLPLGTRQVG-DHVVFFNFGYE
MLBr_00130|M.leprae_Br4923 S-------------------MYKRVWRFWYPLMTHKLGTDEIMFINWAYE
MUL_2377|M.ulcerans_Agy99 S-------------------IYKRVWRYWYPLMTRGLGADKIAFLNWAYE
MSMEG_0393|M.smegmatis_MC2_155 --------------------VAQQAQKLVYRYATRRLKDDDVVFLNYGYE
Mflv_4269|M.gilvum_PYR-GCK -----------------VPAPTPHATKEQVEAALHDTKLAQVLYHDWEAE
TH_2189|M.thermoresistible__bu -----------------LPAPNPHATAEQVEAAMRDSKLAQILYHDWEAE
MMAR_3393|M.marinum_M --------------------MNQQDSPSTCYRAEPVDAQAFTAHFDRLYT
Mvan_2948|M.vanbaalenii_PYR-1 ------------------------------MAPTNDQAARWNRYWDKKSR
MAB_4613|M.abscessus_ATCC_1997 ---------------------MTTADGLHSGDPSPVHRRAFNDQVTRFWG
MAV_3373|M.avium_104 ------------------------MTLDTTTADASVAARHRTVWALGDYA
Mb1550|M.bovis_AF2122/97 E-DPPMALPLSE-SDEPNRYCIQLYHQTASQVDLTGKEVLEVSCGAGGGA
Rv1523|M.tuberculosis_H37Rv E-DPPMALPLSE-SDEPNRYCIQLYHQTASQVDLTGKEVLEVSCGAGGGA
MLBr_00130|M.leprae_Br4923 E-DPPMALPLEA-SDEPNRAHINLYHRTATQVNLSGKRILEVSCGHGGGA
MUL_2377|M.ulcerans_Agy99 E-DPPIDLTLEV-SDEPNRDHINMYHRTATHVELSGKRVLEVSCGHGGGA
MSMEG_0393|M.smegmatis_MC2_155 E-DPPMGIPLSE-SDELNRYSIQLYHSTAAQADVEGKRVLEVGCGHGGGA
Mflv_4269|M.gilvum_PYR-GCK TYDDKWSISYDQRCVDYARGRFDAAVPEEVQRELPYDRALELGCGTGFFL
TH_2189|M.thermoresistible__bu SYDDKWSISYDQRCVDYARGRFDAIVPDHVQRELPYDNALELGCGTGFFL
MMAR_3393|M.marinum_M RLARPYDLAVKL-------LPVWRHWISAALPHIRGPRVLEVSFGTG---
Mvan_2948|M.vanbaalenii_PYR-1 TYDREIGFFDRH---------LFGDSRQWVCSQATG-DVLEVAVGTG---
MAB_4613|M.abscessus_ATCC_1997 RAARAYDWAPLQ----QWVYRPAQDEMLAQLRQHKSQRIVDIACGTGILA
MAV_3373|M.avium_104 LMAEEVMAPLGP-------------TLVEAAGIGPGVRVLDVAAGSG--N
:::. * *
Mb1550|M.bovis_AF2122/97 SYIARNLGPASYTGLDLNPASIDLCRAKHRLPGLQFVQ--GDAQNLPFPD
Rv1523|M.tuberculosis_H37Rv SYIARNLGPASYTGLDLNPASIDLCRAKHRLPGLQFVQ--GDAQNLPFPD
MLBr_00130|M.leprae_Br4923 SYLTRALHPASYTGLDLNPAGIKLCQKRHQLPGLEFVR--GDAENLPFDN
MUL_2377|M.ulcerans_Agy99 SYLTRTLHPASYTGLDLNRAGIKLCQRRHNLPGLDFVR--GDAENLPFED
MSMEG_0393|M.smegmatis_MC2_155 SYLARTFRPATYTGLDLNSDGINFCRRRHNIAGLEFVQ--GDAQDLPFPD
Mflv_4269|M.gilvum_PYR-GCK LNLIQAGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYED
TH_2189|M.thermoresistible__bu LNLIQSGVARRGSVTDLSPGMVRVATRNGRSLGLDVDGRVADAEGIPYDD
MMAR_3393|M.marinum_M WLLTRYANNFDTYGVDLNRRMVAMARRNLRRAGVSADLSQANVEALPYPD
Mvan_2948|M.vanbaalenii_PYR-1 LNLNFYPDDVALTGIDWSEQMLERARRRAAEIGRTATLQQADAHHLPFED
MAB_4613|M.abscessus_ATCC_1997 TRIQDELEPEQVHGVDMSEGMLAQAKARSSLVNWQFAP----AEKLPFDD
MAV_3373|M.avium_104 ITLPAAAAGASVVSTDLTPELLQRSRDRAAGMGLTIDYREANAQALPFGD
: * . : . . . .. :*: :
Mb1550|M.bovis_AF2122/97 ESFDAVVNVEASHQYPDFRGFLAEVARVLRPGGHFLYTDS----------
Rv1523|M.tuberculosis_H37Rv ESFDAVVNVEASHQYPDFRGFLAEVARVLRPGGHFLYTDS----------
MLBr_00130|M.leprae_Br4923 ESFDVVINIEASHCYPHFPRFLAEVVRVLRPGGHLAYADL----------
MUL_2377|M.ulcerans_Agy99 ESFDVVLKVEASHCYPHFSRFLAEVVRVLRPGGYLLYTDL----------
MSMEG_0393|M.smegmatis_MC2_155 KNFDAVLNVESSHLYPRFDVFLTEVARVLRPGGYFLYTDA----------
Mflv_4269|M.gilvum_PYR-GCK NTFDLVVGHAVLHHIPDVELSLREVVRVLKPGGRFVFAGEPTTVGNRYAR
TH_2189|M.thermoresistible__bu NTFDLVVGHAVLHHIPDVELSLREVVRVLRPGGRFVFAGEPTTVGNSYAR
MMAR_3393|M.marinum_M GQFDTVVNTMSFSGYPNGARAMTQLHRVLRRQGRLVLIDVG---------
Mvan_2948|M.vanbaalenii_PYR-1 ASFDTVVCTFGLCAIPDHAQALTEMARVLRPGGKLVLVDH----------
MAB_4613|M.abscessus_ATCC_1997 GALDAVVSTSAFHFF-DQPAALTEFHRVLTPGGFAAITTFT---------
MAV_3373|M.avium_104 GEFDAVVSAIGVQFAPDHQRAADELVRVCRPGGRIGLISWTPEG------
:* *: :. ** *
Mb1550|M.bovis_AF2122/97 -----------------------RRNPVVAEWEAALADAPLRTISQRDIG
Rv1523|M.tuberculosis_H37Rv -----------------------RRNPVVAEWEAALADAPLRTISQRDIG
MLBr_00130|M.leprae_Br4923 -----------------------RPSNKVGEWEVDFANSRLQQLSQREIN
MUL_2377|M.ulcerans_Agy99 -----------------------RPSNEIAEWEADLAGSPLRQLSQREIN
MSMEG_0393|M.smegmatis_MC2_155 -----------------------RPRYDIPEWERALADAPLQMLSQRAIN
Mflv_4269|M.gilvum_PYR-GCK ELSTLTWHAATNIMKLPMLSDWRRPQAELDESSRAAALEAVVDLHTFDPA
TH_2189|M.thermoresistible__bu ALSTLTWHVATTVTRLPGLQGWRRPQAELDESSRAAALEAVVDLHTFEPS
MMAR_3393|M.marinum_M -----------------------------YPQDGNRLGTALAGMWQR--A
Mvan_2948|M.vanbaalenii_PYR-1 ---------------------------VQSTAAPVRAVQRLLEVFTVPLA
MAB_4613|M.abscessus_ATCC_1997 ----------------------------PDRTSAPILRRVFGDRIPASVP
MAV_3373|M.avium_104 ---------------------FFGRMLATIRPYRPSLSHPVPPAALWGRP
.
Mb1550|M.bovis_AF2122/97 AQAKRGLDANTARSQEAIGRRAPVLLA-----------------------
Rv1523|M.tuberculosis_H37Rv AQAKRGLDANTARSQEAIGRRAPVLLA-----------------------
MLBr_00130|M.leprae_Br4923 AEVLRGIASNSQKSRDLVDRHLPAFLR-----------------------
MUL_2377|M.ulcerans_Agy99 AEVVRGIEKNSHTSRVLVDRNLPAFLR-----------------------
MSMEG_0393|M.smegmatis_MC2_155 FEVVRGMEKNLDALESVVDRVAPALLRD----------------------
Mflv_4269|M.gilvum_PYR-GCK DLERMAANAGAVEVRTASEEFTAAMLGWPVRTFEAAVPPG------RLGW
TH_2189|M.thermoresistible__bu DLERMARNAGAVEVATASEEFTAAMLGWPVRTFEAAVPPG------KLGW
MMAR_3393|M.marinum_M GDVIRDMPTLLDDFGFEVQHEQIGGFG-----------------------
Mvan_2948|M.vanbaalenii_PYR-1 GEHFLRRPLSHIRSATGLEIDRVERFK-----------------------
MAB_4613|M.abscessus_ATCC_1997 SKAEMRLMFETAGFEVTVQRPVHHPFTLP---------------------
MAV_3373|M.avium_104 GYVRALLGERIGEITTARGMLPVNRFGSAEDVHAYFKQHYGPTIEAYANI
:
Mb1550|M.bovis_AF2122/97 ------GLTRCAVRVLDWDLRR---GGGFSYRIYLFAKD-----
Rv1523|M.tuberculosis_H37Rv ------GLTRCAVRVLDWDLRR---GGGFSYRIYLFAKD-----
MLBr_00130|M.leprae_Br4923 ------FAGREFIGVQGTQLSRYLEGGELSYRMYSFAKD-----
MUL_2377|M.ulcerans_Agy99 ------FADR----AVGRQLSRYLEGGELSYRMYCFTKDFAASR
MSMEG_0393|M.smegmatis_MC2_155 ------WIQKYGPARRAYEELR---ENTTEYRMYCFVKPAE---
Mflv_4269|M.gilvum_PYR-GCK GWAKFAFGSWTTLSWVDANVWRRIVPKGWFYNVMVTGVKPS---
TH_2189|M.thermoresistible__bu NWAKFAFGSWTALSWVDANVWRRVMPKGWFYNVMVTGVKPS---
MMAR_3393|M.marinum_M -----------------------------SVHLYLATKL-----
Mvan_2948|M.vanbaalenii_PYR-1 --------------------------LGLVERLVAHKPVAP---
MAB_4613|M.abscessus_ATCC_1997 --------------------------FIEFDRLTVGIKR-----
MAV_3373|M.avium_104 GHNRVLAAELDAQLVELAAQHLSDGTMGWEYLLVTAEKRSG---
: