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SLGMVNVANATPNAARVLLKNARQECDPVLRTAVGWLSEPLAKMAGYHLGWWDVNGVPVDGSSGKSIRAA LAFGAASACGDARAAAPVAAAVELMHNFSLVHDDVMDRDATRRGRATVWAVWGETNAIVLGDALHALAGR VLVEMLEPEVAANAVMRLESSCVTLCDGQFEDCDFETRESVSVDGYLEMAAGKTAGLMGCACALGALAAN ADPATVTAMHQFGFQLGLAFQIVDDVMGLWGDPNVTGKPVGSDLARRKKTFPVVAALGSGSEAAASLAQL YGAKEPMSADDVRQAIDLVETAGGRKAAERQADECIGAALAALPDSARSEDLIALTQLVIARDR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3219 | idsB_1 | - | 100% (345) | polyprenyl synthetase IdsB_1 |
| M. marinum M | MMAR_3212 | idsB_2 | e-138 | 70.93% (344) | polyprenyl synthetase IdsB_2 |
| M. marinum M | MMAR_0282 | idsB_3 | e-117 | 63.61% (327) | polyprenyl synthetase IdsB_3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3415c | idsB | 1e-111 | 59.13% (345) | polyprenyl synthetase IdsB |
| M. gilvum PYR-GCK | Mflv_2975 | - | 8e-26 | 31.79% (280) | polyprenyl synthetase |
| M. tuberculosis H37Rv | Rv3383c | idsB | 1e-111 | 59.13% (345) | polyprenyl synthetase IdsB |
| M. leprae Br4923 | MLBr_02277 | - | 4e-24 | 31.34% (268) | polyprenyl diphosphate synthase component |
| M. abscessus ATCC 19977 | MAB_1992c | - | 9e-24 | 31.58% (304) | polyprenyl synthetase |
| M. avium 104 | MAV_4581 | - | 2e-26 | 33.46% (266) | polyprenyl synthetase |
| M. smegmatis MC2 155 | MSMEG_1133 | - | 3e-26 | 33.71% (267) | bifunctional short chain isoprenyl diphosphate synthase |
| M. thermoresistible (build 8) | TH_0708 | idsA2 | 4e-25 | 31.93% (285) | PROBABLE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA2 |
| M. ulcerans Agy99 | MUL_3197 | idsB | 3e-88 | 52.73% (330) | polyprenyl synthetase IdsB |
| M. vanbaalenii PYR-1 | Mvan_0992 | - | 2e-24 | 32.96% (270) | trans-hexaprenyltranstransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1133|M.smegmatis_MC2_155 -------------------MVAGVDFGDPAFAADVRDGVARIEDLMSDEL
Mvan_0992|M.vanbaalenii_PYR-1 -------------------MVAGVDFGDAEFAQDVRDGVARIEALMSEEL
MLBr_02277|M.leprae_Br4923 ------------------MVVAGINFGDAAFAATVQDRVVRIEQLMDAEL
MAV_4581|M.avium_104 -----------------------MDFGDPAFAATVRDGVGRIEQLMDTEL
Mb3415c|M.bovis_AF2122/97 MGGVLTLDAAFLGSVPADLGKALLERARADCGPVLHRAIESMREPLATMA
Rv3383c|M.tuberculosis_H37Rv MGGVLTLDAAFLGSVPADLGKALLERARADCGPVLHRAIESMREPLATMA
MUL_3197|M.ulcerans_Agy99 ----MTADGTCESDVPAAVVQLFLSSARAACDPVLRRAVESMPEPLATMA
MMAR_3219|M.marinum_M ----MSLGMVNVANATPNAARVLLKNARQECDPVLRTAVGWLSEPLAKMA
Mflv_2975|M.gilvum_PYR-GCK ---------------MDAAAPSAVELVNAVNEELREYLRGRRRDAAYIGT
TH_0708|M.thermoresistible__bu -----------------------VELANAVTDELRDYLRQRREDSAYIGS
MAB_1992c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155 GKADELMAEAVQHLFQAGGKRFRPLFTVLSAQLGPEPDAWQVTVAG---A
Mvan_0992|M.vanbaalenii_PYR-1 GKADVLMAEAVQHLFQAGGKRFRPLFTVLSAQLGPEPDAWQVTVAG---A
MLBr_02277|M.leprae_Br4923 RDTDEVMTESVLHLFAAGGKRFRPLFTVLSAQIGPRPDAPEVIIAG---A
MAV_4581|M.avium_104 RSADDIMTELLTHLFKAGGKRFRPLFTVLSAQIGPDPDAAEVTIAG---A
Mb3415c|M.bovis_AF2122/97 GYHLGWWNADRSTAAGSSGKYFRAALVYAAAAACGGDVGDATPVSA----
Rv3383c|M.tuberculosis_H37Rv GYHLGWWNADRSTAAGSSGKYFRAALVYAAAAACGGDVGDATPVSA----
MUL_3197|M.ulcerans_Agy99 GYYLGWWDIDRSALAGSSGTFVRAALVWAAAAACGGDAGNAAPIAA----
MMAR_3219|M.marinum_M GYHLGWWDVNGVPVDGSSGKSIRAALAFGAASACG-DARAAAPVAA----
Mflv_2975|M.gilvum_PYR-GCK DYAVLTEALEEFVLRG--GKRLRPAFAYWGFRAVAGTEP--EPHIMRLFS
TH_0708|M.thermoresistible__bu DYTHMTAALEEFVLRG--GKRIRPAFAYWGWRAVADEPAPVPPEIMRLFA
MAB_1992c|M.abscessus_ATCC_199 ------------MLRG--GKRLRPAFAYWGWRAITDDPDPWNPEVLRVCA
*. .*. :. .
MSMEG_1133|M.smegmatis_MC2_155 VIELVHLATLYHDDVMDEAQMRRG-----------AQSANAR-----WGN
Mvan_0992|M.vanbaalenii_PYR-1 VIELVHLATLYHDDVMDEAQVRRG-----------APSANAR-----WSN
MLBr_02277|M.leprae_Br4923 VIELVHLASLYHDDVMDEAEVRRG-----------APSANLR-----WSN
MAV_4581|M.avium_104 VIELVHLATLYHDDVMDEAEVRRG-----------TPTANVR-----WGN
Mb3415c|M.bovis_AF2122/97 AVELVHNFTLLHDDVMDGDATRRG------------RPTVWS----VWGV
Rv3383c|M.tuberculosis_H37Rv AVELVHNFTLLHDDVMDGDATRRG------------RPTVWS----VWGV
MUL_3197|M.ulcerans_Agy99 AVELVHSGTLLHDDVMAGEVTRGG------------RRAVWS----IWGI
MMAR_3219|M.marinum_M AVELMHNFSLVHDDVMDRDATRRG------------RATVWA----VWGE
Mflv_2975|M.gilvum_PYR-GCK ALELLHACALVHDDLIDASATRRGLPTVHRIFSERHRSNNWLGSSDQFGL
TH_0708|M.thermoresistible__bu ALELLHACALVHDDVIDASATRRGLPTVHRLFADTHRSRGWRGSAEQFGL
MAB_1992c|M.abscessus_ATCC_199 ALELLHTCALIHDDVIDSSATRRGEPTIHVEFAALHRENGWSGSPEQFGI
.:**:* :* ***:: * * :.
MSMEG_1133|M.smegmatis_MC2_155 NIAILAGDYLFATASRLVSRLG-----PDAVRVIADTFAQLVTG-QMRET
Mvan_0992|M.vanbaalenii_PYR-1 NIAILAGDYLFATASRLVSRLG-----PDAVRIIADTFALLVTG-QMRET
MLBr_02277|M.leprae_Br4923 SVAILAGDYLFATASRLVSQLG-----LDAVRIIADTFAQLVTG-QMRET
MAV_4581|M.avium_104 NVAILAGDYLFATASRLVSRLG-----PEAVQLIAETFAQLVTG-QMRET
Mb3415c|M.bovis_AF2122/97 GGAILLGDALHATAVRILTGLTDECVAVRAIRRLQMSCLDLCIG-QFEDC
Rv3383c|M.tuberculosis_H37Rv GVAILLGDALHATAVRILTGLTDECVAVRAIRRLQMSCLDLCIG-QFEDC
MUL_3197|M.ulcerans_Agy99 DNAILLGDALQTAAIRTLTDLPDPGVAVRAVMRLETSCLDLCIG-RFEDC
MMAR_3219|M.marinum_M TNAIVLGDALHALAGRVLVEMLEPEVAANAVMRLESSCVTLCDG-QFEDC
Mflv_2975|M.gilvum_PYR-GCK SAAILLGDLSLVWADDIIAEAPIDDAAHRRVQRVWAAIRTEVLGGQYLDI
TH_0708|M.thermoresistible__bu SAAILLGDLALVWADDAVGSAGLSVDAHRRVRRVWADIRTEVLGGQYLDI
MAB_1992c|M.abscessus_ATCC_199 SAAILLGDLALTWADDMVVGAQLSPEAHVRARGVWSILRSEVLGGQYLDI
**: ** . * : : * : :
MSMEG_1133|M.smegmatis_MC2_155 RGAADHVDSVDHYLKVVYEKTACLIA-ASGRFGATFSGANDEQIERLSRL
Mvan_0992|M.vanbaalenii_PYR-1 RGAADHVDEVDHYLKVVYEKTACLIA-ASGRFGATFSGADDEQIERLARL
MLBr_02277|M.leprae_Br4923 RGVPEGADSIEQYLKVVYEKTGCLIG-SAGRLGGLFAGAHAEQVERLSRL
MAV_4581|M.avium_104 RGRKEGSDPIEHYLKVVYEKTACLIA-AAGRFGAMFSGADADQVERLSRL
Mb3415c|M.bovis_AF2122/97 LLEGQPEVTVDDYLRMAAGKTAALTG-CCCALGALVANADDATIAALERF
Rv3383c|M.tuberculosis_H37Rv LLEGQPEVTVDDYLRMAAGKTAALTG-CCCALGALVANADDATIAALERF
MUL_3197|M.ulcerans_Agy99 AFECGQAGPVDSYERMAAGKTAALIG-CCCGLGALAADAGDATITALERF
MMAR_3219|M.marinum_M DFETRESVSVDGYLEMAAGKTAGLMG-CACALGALAANADPATVTAMHQF
Mflv_2975|M.gilvum_PYR-GCK VNEASGSETVASALTVNIYKTASYTISRPLQLGAAAAGDRPEILEAFHEL
TH_0708|M.thermoresistible__bu VNESSGADSVASAMTVNTYKTASYTVTRPLQLGAAAAADRPDVLATFHEV
MAB_1992c|M.abscessus_ATCC_199 LSESSGDESVETALRVIRFKTAGYTVQRPLQLGVAIAGENAEISRLLGDV
: : **. :* : : .
MSMEG_1133|M.smegmatis_MC2_155 GGIVGTAFQIADDIIDIDSDPDESGKTPGTDLREGVHTLPVLYALR---E
Mvan_0992|M.vanbaalenii_PYR-1 GGIVGTAFQISDDIIDIDSDPDESGKVPGTDLREGVHTLPVLYALR---E
MLBr_02277|M.leprae_Br4923 GSIVGTAFQISDDIIDIDSDYTKSGKLPGTDVREGVRTLPILYALR---E
MAV_4581|M.avium_104 GGIVGTAFQISDDIIDIDSDSHESGKLPGTDVREGVHTLPMVYALR---E
Mb3415c|M.bovis_AF2122/97 GHELGLAFQCVDDLIGIWGDPGVTGKPVGNDLARRKATLPVVAALNSRSE
Rv3383c|M.tuberculosis_H37Rv GHELGLAFQCVDDLIGIWGDPGVTGKPVGNDLARRKATLPVVAALNSRSE
MUL_3197|M.ulcerans_Agy99 GRELGLAFQCVN------------------DLGRRNATLTVAAALNSRSE
MMAR_3219|M.marinum_M GFQLGLAFQIVDDVMGLWGDPNVTGKPVGSDLARRKKTFPVVAALGSGSE
Mflv_2975|M.gilvum_PYR-GCK GTSLGVAFQLRDDVLGVYGDPAVTGKPSGDDLRSGKRTVLLAEAVELADR
TH_0708|M.thermoresistible__bu GNDLGVAFQLRDDVLGVFGDPAVTGKPSGDDLRSGKRTVLLAEAVELAEQ
MAB_1992c|M.abscessus_ATCC_199 GLDIGIAFQLRDDVLGVFGDPKVTGKPAGDDLRSGKRTVLLAEALRLARQ
* :* *** : *: *. : *: .
MSMEG_1133|M.smegmatis_MC2_155 TGPDADRLRELLAGPIERDEDVAEALALLRRSPGLTKAKETVASYAAQAR
Mvan_0992|M.vanbaalenii_PYR-1 TGPDADRLRELLATPVTDDGDLAEALRLLRASDGITKAKETVAAYAREAE
MLBr_02277|M.leprae_Br4923 TGPDSERLRALLAGPVDNDAEVVEALALLRASPGMARARQVLAHYADQAS
MAV_4581|M.avium_104 PGPDAARLRELLVGPIDDDEVVAEALTLLRASPGMAKAKQSLREYAAQAH
Mb3415c|M.bovis_AF2122/97 AATELAALYQ--APAAMTASDVERATALVKVAGGGHVAQRCADERIQAAI
Rv3383c|M.tuberculosis_H37Rv AATELAALYQ--APAAMTASDVERATALVKVAGGGHVAQRCADERIQAAI
MUL_3197|M.ulcerans_Agy99 AAIEPAALCH--SGSFMATGDIDRAATLVDVAAGRHAVQRCADQRIQATV
MMAR_3219|M.marinum_M AAASLAQLYG--AKEPMSADDVRQAIDLVETAGGRKAAERQADECIGAAL
Mflv_2975|M.gilvum_PYR-GCK HDPPAAQLLRTSIGTDLSDAQVKELCLVIEAVGALAAVESRIDTLTRRAL
TH_0708|M.thermoresistible__bu RDPAAAELLRTAIGTELSDEQVTEVCGAIEKVGALRAVEDRIETLTTRAL
MAB_1992c|M.abscessus_ATCC_199 RDSAAEDLLHSWIGTPLTDQQVAEMCSLIVDLGALGAVESRIEEHTHRAL
* : . : . .. :
MSMEG_1133|M.smegmatis_MC2_155 EELSHLP-ECPGRQALAVLVDYTISREG
Mvan_0992|M.vanbaalenii_PYR-1 QELGQLP-AGPGRQALATLVQYTINRHG
MLBr_02277|M.leprae_Br4923 GELAQLP-DGPSRDALATLVDYTTNRHG
MAV_4581|M.avium_104 RELDQLP-DVPGRRALQTLVDFTISRHG
Mb3415c|M.bovis_AF2122/97 AALP----DAVRSPDLIALSQLICRREC
Rv3383c|M.tuberculosis_H37Rv AALP----DAVRSPDLIALSQLICRREC
MUL_3197|M.ulcerans_Agy99 AALP----DAVRSRDLIALSQLICCRER
MMAR_3219|M.marinum_M AALP----DSARSEDLIALTQLVIARDR
Mflv_2975|M.gilvum_PYR-GCK DIMNSAPIDVRAKAGLAELARLAANRSA
TH_0708|M.thermoresistible__bu RRLDAAPIHEAAKVGLSELARSAANRSA
MAB_1992c|M.abscessus_ATCC_199 DQLAGADIADDARAALSDLVRLVSNRSA
: * * *