For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. thermoresistible (build 8) TH_0708 (idsA2)

annotation: PROBABLE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA2 (GGPPSASE) (GGPP SYNTHETASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE)
coordinates: 1514382 - 1515443
length: 354

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_0708 idsA2 - 100% (354) PROBABLE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA2 (GGPPSASE) (GGPP SYNTHETASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE)
M. thermoresistible (build 8) TH_1767 - 6e-19 25.71% (319) bifunctional short chain isoprenyl diphosphate synthase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb2195 idsA2 1e-126 67.61% (355) geranylgeranyl pyrophosphate synthetase
M. gilvum PYR-GCK Mflv_2975 - 1e-148 74.86% (354) polyprenyl synthetase
M. tuberculosis H37Rv Rv2173 idsA2 1e-126 67.61% (355) geranylgeranyl pyrophosphate synthetase
M. leprae Br4923 MLBr_02277 - 2e-21 27.61% (268) polyprenyl diphosphate synthase component
M. abscessus ATCC 19977 MAB_1992c - 1e-112 64.65% (314) polyprenyl synthetase
M. marinum M MMAR_3208 idsA2 1e-125 67.54% (342) geranylgeranyl pyrophosphate synthetase IdsA2
M. avium 104 MAV_2321 - 1e-134 71.51% (351) polyprenyl synthetase
M. smegmatis MC2 155 MSMEG_4240 - 1e-147 75.14% (354) polyprenyl synthetase
M. ulcerans Agy99 MUL_3516 idsA2 1e-122 66.67% (342) geranylgeranyl pyrophosphate synthetase IdsA2
M. vanbaalenii PYR-1 Mvan_3536 - 1e-151 77.12% (354) polyprenyl synthetase

CLUSTAL 2.0.9 multiple sequence alignment


Mb2195|M.bovis_AF2122/97            ----------MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLG
Rv2173|M.tuberculosis_H37Rv         ----------MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLG
MAV_2321|M.avium_104                ----------MTGAITEQLRRYLHDRRAETAYIGDDYSGLIAALEEFVLN
MMAR_3208|M.marinum_M               ----------------------MRDRRSQAAYIGDDYGALTAWLEEFVLS
MUL_3516|M.ulcerans_Agy99           ----------------------MRDRRSQAAYIGDDYGALTAWLEEFVLS
Mflv_2975|M.gilvum_PYR-GCK          MDAAAPSAVELVNAVNEELREYLRGRRRDAAYIGTDYAVLTEALEEFVLR
Mvan_3536|M.vanbaalenii_PYR-1       MDASAPSAVELAAAVTEQLRDYLRARRRDAAYIGAGYAVLTEAVEEFVLR
TH_0708|M.thermoresistible__bu      --------VELANAVTDELRDYLRQRREDSAYIGSDYTHMTAALEEFVLR
MSMEG_4240|M.smegmatis_MC2_155      MDTAAPSAVELAGAVTEQLREYLRERRSDCAYIGPVYAELTAGVEEFVLR
MAB_1992c|M.abscessus_ATCC_199      -----------------------------------------------MLR
MLBr_02277|M.leprae_Br4923          -MVVAGINFGDAAFAATVQDRVVRIEQLMDAELRDTDEVMTESVLHLFAA
                                                                                   .  

Mb2195|M.bovis_AF2122/97            GGKRLRPLFAYWGWHAVAS-REP--DPDVLLLFSALELLHAWALVHDDLI
Rv2173|M.tuberculosis_H37Rv         GGKRLRPLFAYWGWHAVAS-REP--DPDVLLLFSALELLHAWALVHDDLI
MAV_2321|M.avium_104                GGKRLRPAFAYWGWRAVAT-EAP--DDQALLLFSALELLHACALVHDDVI
MMAR_3208|M.marinum_M               GGKRLRPIFAYRGWQAVTT-EDP--DPDLLLLFSALELLHAWALIHDDVI
MUL_3516|M.ulcerans_Agy99           GGKRLRPIFAYRGWPAVTT-EDP--DPDLLLLFSALELLHAWALIHDDVI
Mflv_2975|M.gilvum_PYR-GCK          GGKRLRPAFAYWGFRAVAG-TEP--EPHIMRLFSALELLHACALVHDDLI
Mvan_3536|M.vanbaalenii_PYR-1       GGKRLRPAFAYWGWRAVAG-TEP--GPEALRLFSALELLHACALVHDDVI
TH_0708|M.thermoresistible__bu      GGKRIRPAFAYWGWRAVAD-EPAPVPPEIMRLFAALELLHACALVHDDVI
MSMEG_4240|M.smegmatis_MC2_155      GGKRVRPAFAYWGWRSVIEPADAVAGPDVLRLFSALELLQACALIHDDVI
MAB_1992c|M.abscessus_ATCC_199      GGKRLRPAFAYWGWRAITDDPDP-WNPEVLRVCAALELLHTCALIHDDVI
MLBr_02277|M.leprae_Br4923          GGKRFRPLFTVLSAQIGPRPDAP----EVIIAGAVIELVHLASLYHDDVM
                                    ****.** *:  .         .    . :   :.:**::  :* ***::

Mb2195|M.bovis_AF2122/97            DRSATRRGRPTAQLRYAALHRDRDWRGSPDQFGMSAAILLGDLAQVWADD
Rv2173|M.tuberculosis_H37Rv         DRSATRRGRPTAQLRYAALHRDRDWRGSPDQFGMSAAILLGDLAQVWADD
MAV_2321|M.avium_104                DDSATRRGRPTTHVRFASLHRDRQWQGSPERFGMSAAILLGDLALAWADD
MMAR_3208|M.marinum_M               DASSTRRGRPTAHMHFAALHRDRNWLGPAQQFGISAAILIGDVAQAWADD
MUL_3516|M.ulcerans_Agy99           DASSTRRGRPMAHIHFAALHRDRNWLGPAQQFGISAAILIGDVAQAWADD
Mflv_2975|M.gilvum_PYR-GCK          DASATRRGLPTVHRIFSERHRSNNWLGSSDQFGLSAAILLGDLSLVWADD
Mvan_3536|M.vanbaalenii_PYR-1       DASATRRGLPTVHRIFAERHRSNNWLGSSEQFGLSAAILLGDVALVWADD
TH_0708|M.thermoresistible__bu      DASATRRGLPTVHRLFADTHRSRGWRGSAEQFGLSAAILLGDLALVWADD
MSMEG_4240|M.smegmatis_MC2_155      DDSATRRGLPTVHRLFTEQHHERGWLGSERQFGLSAAILAGDLALSWADD
MAB_1992c|M.abscessus_ATCC_199      DSSATRRGEPTIHVEFAALHRENGWSGSPEQFGISAAILLGDLALTWADD
MLBr_02277|M.leprae_Br4923          DEAEVRRGAPSANLRWSN----------------SVAILAGDYLFATASR
                                    * : .*** *  :  ::                 *.*** **     *. 

Mb2195|M.bovis_AF2122/97            IVSKVCQSALAPDAQRRVHRVWADIRNEVLGGQYLDIVAEASAAESIESA
Rv2173|M.tuberculosis_H37Rv         IVSKVCQSALAPDAQRRVHRVWADIRNEVLGGQYLDIVAEASAAESIESA
MAV_2321|M.avium_104                IVLGV---DLTPQAARRVRRVWANIRTEVLGGQYLDIVAEASAAASIASA
MMAR_3208|M.marinum_M               IISRVSQSSLSPDAQRRVQRVWSDIRTEVLGGQYLDIVAEASAADSITSA
MUL_3516|M.ulcerans_Agy99           IISRVSQSSLSPDAQRRVQRVWSDIRTEVLGGQYLDIVAEASAADSITSA
Mflv_2975|M.gilvum_PYR-GCK          IIAEA---PIDDAAHRRVQRVWAAIRTEVLGGQYLDIVNEASGSETVASA
Mvan_3536|M.vanbaalenii_PYR-1       IVASA---EIGVEAHRRVQRVWAAIRTEVLGGQYLDIVNEATGAETVASA
TH_0708|M.thermoresistible__bu      AVGSA---GLSVDAHRRVRRVWADIRTEVLGGQYLDIVNESSGADSVASA
MSMEG_4240|M.smegmatis_MC2_155      IVAGA---DLPVDAHRRVQTVWRHIRTEVLGGQYLDIVTESSGDESVASA
MAB_1992c|M.abscessus_ATCC_199      MVVGA---QLSPEAHVRARGVWSILRSEVLGGQYLDILSESSGDESVETA
MLBr_02277|M.leprae_Br4923          LVSQLG---------LDAVRIIADTFAQLVTGQMRETRGVPEGADSIEQY
                                     :               .  :      ::: **  :    . .  ::   

Mb2195|M.bovis_AF2122/97            MNVATLKTACYTVSRPLQLGTAAAADRSDVAAIFEHFGADLGVAFQLRDD
Rv2173|M.tuberculosis_H37Rv         MNVATLKTACYTVSRPLQLGTAAAADRSDVAAIFEHFGADLGVAFQLRDD
MAV_2321|M.avium_104                MNVDTFKTACYTVSRPLQLGAAAAADRPDVHDLFSQFGTDLGVAFQLRDD
MMAR_3208|M.marinum_M               MTVATFKTACYTVSRPLQLGAAAAADRPDVQEAFHQFGTDLGVAFQLRDD
MUL_3516|M.ulcerans_Agy99           MTVATFKTACYTVSRPLQLGAAAAADRPDVQEAFHQFGTDLGVAFQLRDD
Mflv_2975|M.gilvum_PYR-GCK          LTVNIYKTASYTISRPLQLGAAAAGDRPEILEAFHELGTSLGVAFQLRDD
Mvan_3536|M.vanbaalenii_PYR-1       LTVNIYKTASYTISRPLQLGAAAAADCPEVLSAFHELGTSLGVAFQLRDD
TH_0708|M.thermoresistible__bu      MTVNTYKTASYTVTRPLQLGAAAAADRPDVLATFHEVGNDLGVAFQLRDD
MSMEG_4240|M.smegmatis_MC2_155      LNVNTFKTASYTVARPLQLGAAAAADRPDVQELFHRIGNDLGVAFQLRDD
MAB_1992c|M.abscessus_ATCC_199      LRVIRFKTAGYTVQRPLQLGVAIAGENAEISRLLGDVGLDIGIAFQLRDD
MLBr_02277|M.leprae_Br4923          LKVVYEKTGCLIGS-AGRLGGLFAGAHAEQVERLSRLGSIVGTAFQISDD
                                    : *   **.      . :**   *.  .:    :  .*  :* ***: **

Mb2195|M.bovis_AF2122/97            VLGVFGDPAVTGKPSGDDLKSGKRTVLVAEAVELADRSDPLAAKLLRTSI
Rv2173|M.tuberculosis_H37Rv         VLGVFGDPAVTGKPSGDDLKSGKRTVLVAEAVELADRSDPLAAKLLRTSI
MAV_2321|M.avium_104                VLGVFGDPAVTGKPSGDDLRSGKRTVLLAEAVELAEKSDPLAAKLLRDSI
MMAR_3208|M.marinum_M               VLGVFGDPAVTGKPSGDDLRSGKRTVLIAEAAALADRSDPKAANLLRSAV
MUL_3516|M.ulcerans_Agy99           VLGVFGDPAMTGKPSGDDLRSGKRTVLIAEAAALADRSDPKAANLLRSAV
Mflv_2975|M.gilvum_PYR-GCK          VLGVYGDPAVTGKPSGDDLRSGKRTVLLAEAVELADRHDPPAAQLLRTSI
Mvan_3536|M.vanbaalenii_PYR-1       VLGVFGDPAVTGKPSGDDLRSGKRTVLLAEAVELAEKHDQIAAKLLRTSI
TH_0708|M.thermoresistible__bu      VLGVFGDPAVTGKPSGDDLRSGKRTVLLAEAVELAEQRDPAAAELLRTAI
MSMEG_4240|M.smegmatis_MC2_155      VLGVFGDPAVTGKPSGDDLRSGKRTVLLAEALELADASDPAAAALLRRSV
MAB_1992c|M.abscessus_ATCC_199      VLGVFGDPKVTGKPAGDDLRSGKRTVLLAEALRLARQRDSAAEDLLHSWI
MLBr_02277|M.leprae_Br4923          IIDIDSDYTKSGKLPGTDVREGVRTLPILYALRETG---PDSERLRALLA
                                    ::.: .*   :** .* *::.* **: :  *   :      :  *     

Mb2195|M.bovis_AF2122/97            GTRLTDAQVRELRTVIEAVGARAAAESRIAALTQRALATLASAPINATAK
Rv2173|M.tuberculosis_H37Rv         GTRLTDAQVRELRTVIEAVGARAAAESRIAALTQRALATLASAPINATAK
MAV_2321|M.avium_104                GAQLSDAEVDRLRDVIESVGALAAAEQRIATLTQRALATLAAAPINTAAK
MMAR_3208|M.marinum_M               GSELTDSQVGELREVIVRVGALAAAENRIAGLTRRALATLESIPINASAK
MUL_3516|M.ulcerans_Agy99           GSELTDSQVGELREVIVRVGALAAAENRNAGLTRRALATLESIPINASAK
Mflv_2975|M.gilvum_PYR-GCK          GTDLSDAQVKELCLVIEAVGALAAVESRIDTLTRRALDIMNSAPIDVRAK
Mvan_3536|M.vanbaalenii_PYR-1       GTDLTDAQVKEVCLVIESVGALAAVESRIDTLTRRALDILNSAPIDVQAK
TH_0708|M.thermoresistible__bu      GTELSDEQVTEVCGAIEKVGALRAVEDRIETLTTRALRRLDAAPIHEAAK
MSMEG_4240|M.smegmatis_MC2_155      GTELSDTQVRELCDAIESVGALAAVEQRIETLTRDALDVLAAANVHPQAK
MAB_1992c|M.abscessus_ATCC_199      GTPLTDQQVAEMCSLIVDLGALGAVESRIEEHTHRALDQLAGADIADDAR
MLBr_02277|M.leprae_Br4923          GPVDNDAEVVEALALLRASPGMARARQVLAHYADQASGELAQLP-DGPSR
                                    *.  .* :* .    :    .   ...     :  *   :        ::

Mb2195|M.bovis_AF2122/97            AGLSELAMMAANRSA
Rv2173|M.tuberculosis_H37Rv         AGLSELAMMAANRSA
MAV_2321|M.avium_104                AGLSELAKLATNRSA
MMAR_3208|M.marinum_M               AGLSALARTATDRSA
MUL_3516|M.ulcerans_Agy99           AGLSALARTATDRSA
Mflv_2975|M.gilvum_PYR-GCK          AGLAELARLAANRSA
Mvan_3536|M.vanbaalenii_PYR-1       AGLAELARMAANRSA
TH_0708|M.thermoresistible__bu      VGLSELARSAANRSA
MSMEG_4240|M.smegmatis_MC2_155      AGLSELARSAANRTA
MAB_1992c|M.abscessus_ATCC_199      AALSDLVRLVSNRSA
MLBr_02277|M.leprae_Br4923          DALATLVDYTTNRHG
                                     .*: *.  .::* .

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_0708	idsA2	-	100% (354)	PROBABLE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA2 (GGPPSASE) (GGPP SYNTHETASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE)
M. thermoresistible (build 8)	TH_1767	-	6e-19	25.71% (319)	bifunctional short chain isoprenyl diphosphate synthase