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TADGTCESDVPAAVVQLFLSSARAACDPVLRRAVESMPEPLATMAGYYLGWWDIDRSALAGSSGTFVRAA LVWAAAAACGGDAGNAAPIAAAVELVHSGTLLHDDVMAGEVTRGGRRAVWSIWGIDNAILLGDALQTAAI RTLTDLPDPGVAVRAVMRLETSCLDLCIGRFEDCAFECGQAGPVDSYERMAAGKTAALIGCCCGLGALAA DAGDATITALERFGRELGLAFQCVNDLGRRNATLTVAAALNSRSEAAIEPAALCHSGSFMATGDIDRAAT LVDVAAGRHAVQRCADQRIQATVAALPDAVRSRDLIALSQLICCRER*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3197 | idsB | - | 100% (328) | polyprenyl synthetase IdsB |
| M. ulcerans Agy99 | MUL_0664 | grcC1 | 2e-11 | 30.41% (148) | polyprenyl diphosphate synthetase, GrcC1 |
| M. ulcerans Agy99 | MUL_3516 | idsA2 | 1e-09 | 26.44% (261) | geranylgeranyl pyrophosphate synthetase IdsA2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3415c | idsB | 1e-117 | 64.06% (345) | polyprenyl synthetase IdsB |
| M. gilvum PYR-GCK | Mflv_5253 | - | 2e-13 | 33.97% (156) | trans-hexaprenyltranstransferase |
| M. tuberculosis H37Rv | Rv3383c | idsB | 1e-117 | 64.06% (345) | polyprenyl synthetase IdsB |
| M. leprae Br4923 | MLBr_02277 | - | 3e-12 | 28.40% (257) | polyprenyl diphosphate synthase component |
| M. abscessus ATCC 19977 | MAB_3928c | - | 3e-11 | 31.10% (164) | polyprenyl-diphosphate synthase GrcC1 |
| M. marinum M | MMAR_2564 | idsB | 0.0 | 98.17% (328) | polyprenyl synthetase IdsB |
| M. avium 104 | MAV_4581 | - | 9e-13 | 31.41% (156) | polyprenyl synthetase |
| M. smegmatis MC2 155 | MSMEG_1133 | - | 2e-14 | 34.39% (157) | bifunctional short chain isoprenyl diphosphate synthase |
| M. thermoresistible (build 8) | TH_1767 | - | 1e-13 | 32.05% (156) | bifunctional short chain isoprenyl diphosphate synthase |
| M. vanbaalenii PYR-1 | Mvan_0992 | - | 6e-13 | 35.67% (157) | trans-hexaprenyltranstransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5253|M.gilvum_PYR-GCK -------------MRTPANVVAGVDFGDAQFAQDVRDGVARIEALMSEEL
Mvan_0992|M.vanbaalenii_PYR-1 -------------------MVAGVDFGDAEFAQDVRDGVARIEALMSEEL
MSMEG_1133|M.smegmatis_MC2_155 -------------------MVAGVDFGDPAFAADVRDGVARIEDLMSDEL
TH_1767|M.thermoresistible__bu -------------------VVAGVDLGDPDFAAGVRDGVARIEDLMSSEL
MLBr_02277|M.leprae_Br4923 ------------------MVVAGINFGDAAFAATVQDRVVRIEQLMDAEL
MAV_4581|M.avium_104 -----------------------MDFGDPAFAATVRDGVGRIEQLMDTEL
MAB_3928c|M.abscessus_ATCC_199 --------------------MAGVDLGDPVFAAKVRDHLAAIETLIVSEL
MUL_3197|M.ulcerans_Agy99 ----MTADGTCESDVPAAVVQLFLSSARAACDPVLRRAVESMPEPLATMA
MMAR_2564|M.marinum_M ----MTADGTCESDVPAEVVQLFLSSARAACDPVLRRAVESMPEPLATMA
Mb3415c|M.bovis_AF2122/97 MGGVLTLDAAFLGSVPADLGKALLERARADCGPVLHRAIESMREPLATMA
Rv3383c|M.tuberculosis_H37Rv MGGVLTLDAAFLGSVPADLGKALLERARADCGPVLHRAIESMREPLATMA
:. . . :: : : :
Mflv_5253|M.gilvum_PYR-GCK GRADALMSEAVNHLFQAGGKRFRPLFTVLSAQLGPEPDAWQVTVAGAVIE
Mvan_0992|M.vanbaalenii_PYR-1 GKADVLMAEAVQHLFQAGGKRFRPLFTVLSAQLGPEPDAWQVTVAGAVIE
MSMEG_1133|M.smegmatis_MC2_155 GKADELMAEAVQHLFQAGGKRFRPLFTVLSAQLGPEPDAWQVTVAGAVIE
TH_1767|M.thermoresistible__bu GKADDLMAEAVQHLFRAGGKRFRPLFTVLSAQLGPEPDAWQVTVAGAVIE
MLBr_02277|M.leprae_Br4923 RDTDEVMTESVLHLFAAGGKRFRPLFTVLSAQIGPRPDAPEVIIAGAVIE
MAV_4581|M.avium_104 RSADDIMTELLTHLFKAGGKRFRPLFTVLSAQIGPDPDAAEVTIAGAVIE
MAB_3928c|M.abscessus_ATCC_199 GQSDPLLTESVLHLFHAGGKRFRPLFTVLAAQTGPDPDNDEVILAGAVCE
MUL_3197|M.ulcerans_Agy99 GYYLGWWDIDRSALAGSSGTFVRAALVWAAAAACGG-DAGNAAPIAAAVE
MMAR_2564|M.marinum_M GYHLGWWDIDRSALAGSSGTFVRAALVWAAAAACGG-DAGNAAPIAAAVE
Mb3415c|M.bovis_AF2122/97 GYHLGWWNADRSTAAGSSGKYFRAALVYAAAAACGG-DVGDATPVSAAVE
Rv3383c|M.tuberculosis_H37Rv GYHLGWWNADRSTAAGSSGKYFRAALVYAAAAACGG-DVGDATPVSAAVE
:.*. .*. :. :* * :. .*. *
Mflv_5253|M.gilvum_PYR-GCK LVHLATLYHDDVMDEAQVRRGAPSANARWGNNIAILAGDYLFATASRLTS
Mvan_0992|M.vanbaalenii_PYR-1 LVHLATLYHDDVMDEAQVRRGAPSANARWSNNIAILAGDYLFATASRLVS
MSMEG_1133|M.smegmatis_MC2_155 LVHLATLYHDDVMDEAQMRRGAQSANARWGNNIAILAGDYLFATASRLVS
TH_1767|M.thermoresistible__bu LVHLATLYHDDVMDDAEMRRGAPSANAKWGNSIAILAGDYLFATASRLVS
MLBr_02277|M.leprae_Br4923 LVHLASLYHDDVMDEAEVRRGAPSANLRWSNSVAILAGDYLFATASRLVS
MAV_4581|M.avium_104 LVHLATLYHDDVMDEAEVRRGTPTANVRWGNNVAILAGDYLFATASRLVS
MAB_3928c|M.abscessus_ATCC_199 LIHLATLYHDDVMDEAQKRRGVPSANARWGNNVAILAGDYLLATASRLVS
MUL_3197|M.ulcerans_Agy99 LVHSGTLLHDDVMAGEVTRGGRRAVWSIWGIDNAILLGDALQTAAIRTLT
MMAR_2564|M.marinum_M LVHSGTLLHDDVMAGEVTRGGRRAVWSIWGIDNAILLGDALQTAAIRTLT
Mb3415c|M.bovis_AF2122/97 LVHNFTLLHDDVMDGDATRRGRPTVWSVWGVGGAILLGDALHATAVRILT
Rv3383c|M.tuberculosis_H37Rv LVHNFTLLHDDVMDGDATRRGRPTVWSVWGVGVAILLGDALHATAVRILT
*:* :* ***** * * :. *. . *** ** * ::* * :
Mflv_5253|M.gilvum_PYR-GCK RLG-----PEAVRIIADTFALLVTGQMRETRGAADQVDSVDHYLKVVYEK
Mvan_0992|M.vanbaalenii_PYR-1 RLG-----PDAVRIIADTFALLVTGQMRETRGAADHVDEVDHYLKVVYEK
MSMEG_1133|M.smegmatis_MC2_155 RLG-----PDAVRVIADTFAQLVTGQMRETRGAADHVDSVDHYLKVVYEK
TH_1767|M.thermoresistible__bu RLG-----PEAVRVIADTFAQLVTGQMRETRGAADGADPIEHYLKVVYEK
MLBr_02277|M.leprae_Br4923 QLG-----LDAVRIIADTFAQLVTGQMRETRGVPEGADSIEQYLKVVYEK
MAV_4581|M.avium_104 RLG-----PEAVQLIAETFAQLVTGQMRETRGRKEGSDPIEHYLKVVYEK
MAB_3928c|M.abscessus_ATCC_199 RLG-----PTAVRIVAETFAELVTGQMRETVGVPEGGDETEHYLKVIHEK
MUL_3197|M.ulcerans_Agy99 DLPDPGVAVRAVMRLETSCLDLCIGRFEDCAFECGQAGPVDSYERMAAGK
MMAR_2564|M.marinum_M DLPDPGVAVRAVMRLETSCLDLCIGRFEDCAFECGQAGPVDSYERMAAGK
Mb3415c|M.bovis_AF2122/97 GLTDECVAVRAIRRLQMSCLDLCIGQFEDCLLEGQPEVTVDDYLRMAAGK
Rv3383c|M.tuberculosis_H37Rv GLTDECVAVRAIRRLQMSCLDLCIGQFEDCLLEGQPEVTVDDYLRMAAGK
* *: : : * *::.: : * :: *
Mflv_5253|M.gilvum_PYR-GCK TACLISASGRFGATFSGSDEAQIERLAKLGGIVGTAFQISDDIIDIDSDA
Mvan_0992|M.vanbaalenii_PYR-1 TACLIAASGRFGATFSGADDEQIERLARLGGIVGTAFQISDDIIDIDSDP
MSMEG_1133|M.smegmatis_MC2_155 TACLIAASGRFGATFSGANDEQIERLSRLGGIVGTAFQIADDIIDIDSDP
TH_1767|M.thermoresistible__bu TACLISASGRFGATFSGADEEQVERLARLGGIVGTAFQISDDIIDIESES
MLBr_02277|M.leprae_Br4923 TGCLIGSAGRLGGLFAGAHAEQVERLSRLGSIVGTAFQISDDIIDIDSDY
MAV_4581|M.avium_104 TACLIAAAGRFGAMFSGADADQVERLSRLGGIVGTAFQISDDIIDIDSDS
MAB_3928c|M.abscessus_ATCC_199 TGSLIAAAGRFGAMTSRCDDDQIERLSRLGAIVGTAFQISDDIIDIESLT
MUL_3197|M.ulcerans_Agy99 TAALIGCCCGLGALAADAGDATITALERFGRELGLAFQCVN---------
MMAR_2564|M.marinum_M TAALIGCCCGLGALAADAGDATIAALERFGRELGLAFQCVN---------
Mb3415c|M.bovis_AF2122/97 TAALTGCCCALGALVANADDATIAALERFGHELGLAFQCVDDLIGIWGDP
Rv3383c|M.tuberculosis_H37Rv TAALTGCCCALGALVANADDATIAALERFGHELGLAFQCVDDLIGIWGDP
*..* ... :*. : . : * ::* :* *** :
Mflv_5253|M.gilvum_PYR-GCK DESGKVPGTDLREGVHTLPVLYALRETGPDADRLRELLAG-PVTDDADVA
Mvan_0992|M.vanbaalenii_PYR-1 DESGKVPGTDLREGVHTLPVLYALRETGPDADRLRELLAT-PVTDDGDLA
MSMEG_1133|M.smegmatis_MC2_155 DESGKTPGTDLREGVHTLPVLYALRETGPDADRLRELLAG-PIERDEDVA
TH_1767|M.thermoresistible__bu TESGKTPGTDLREGVHTLPVLYALRETGPEAERLRELVSR-PVEDDADLA
MLBr_02277|M.leprae_Br4923 TKSGKLPGTDVREGVRTLPILYALRETGPDSERLRALLAG-PVDNDAEVV
MAV_4581|M.avium_104 HESGKLPGTDVREGVHTLPMVYALREPGPDAARLRELLVG-PIDDDEVVA
MAB_3928c|M.abscessus_ATCC_199 DESGKTPGTDLREGVHTLPMLYALRDTGPDADRLRVLLAA-PITDDAEVE
MUL_3197|M.ulcerans_Agy99 ---------DLGRRNATLTVAAALNSRSEAAIEPAALCHSGSFMATGDID
MMAR_2564|M.marinum_M ---------DLGRRNATLTVAAALNSRSDAAIEPAALCHSGSFMATGDID
Mb3415c|M.bovis_AF2122/97 GVTGKPVGNDLARRKATLPVVAALNSRSEAATELAALYQAPAAMTASDVE
Rv3383c|M.tuberculosis_H37Rv GVTGKPVGNDLARRKATLPVVAALNSRSEAATELAALYQAPAAMTASDVE
*: . **.: **.. . : . * . :
Mflv_5253|M.gilvum_PYR-GCK EALRLLRGSQGIRKAKETVIGYAQEAQRELDQLPDVPGRQALASLVDYTV
Mvan_0992|M.vanbaalenii_PYR-1 EALRLLRASDGITKAKETVAAYAREAEQELGQLPAGPGRQALATLVQYTI
MSMEG_1133|M.smegmatis_MC2_155 EALALLRRSPGLTKAKETVASYAAQAREELSHLPECPGRQALAVLVDYTI
TH_1767|M.thermoresistible__bu EALDLLRRSPGMAQATETVREYATEARSVLAQLPAGPGRDALATLIDFTV
MLBr_02277|M.leprae_Br4923 EALALLRASPGMARARQVLAHYADQASGELAQLPDGPSRDALATLVDYTT
MAV_4581|M.avium_104 EALTLLRASPGMAKAKQSLREYAAQAHRELDQLPDVPGRRALQTLVDFTI
MAB_3928c|M.abscessus_ATCC_199 EALALLRASEGLAQAKSVVIDYADRAKAELVELPPGDARDALGVLIEYTV
MUL_3197|M.ulcerans_Agy99 RAATLVDVAAGRHAVQR---CADQRIQATVAALPDAVRSRDLIALSQLIC
MMAR_2564|M.marinum_M RAATLVDVAAGRHAEQR---CADQRIQATVAALPDAVRSRDLIALSQLIC
Mb3415c|M.bovis_AF2122/97 RATALVKVAGGGHVAQR---CADERIQAAIAALPDAVRSPDLIALSQLIC
Rv3383c|M.tuberculosis_H37Rv RATALVKVAGGGHVAQR---CADERIQAAIAALPDAVRSPDLIALSQLIC
.* *: : * . : ** * * :
Mflv_5253|M.gilvum_PYR-GCK NRHG
Mvan_0992|M.vanbaalenii_PYR-1 NRHG
MSMEG_1133|M.smegmatis_MC2_155 SREG
TH_1767|M.thermoresistible__bu NRHG
MLBr_02277|M.leprae_Br4923 NRHG
MAV_4581|M.avium_104 SRHG
MAB_3928c|M.abscessus_ATCC_199 RRHG
MUL_3197|M.ulcerans_Agy99 CRER
MMAR_2564|M.marinum_M RRER
Mb3415c|M.bovis_AF2122/97 RREC
Rv3383c|M.tuberculosis_H37Rv RREC
*.