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GGVLTLDAAFLGSVPADLGKALLERARADCGPVLHRAIESMREPLATMAGYHLGWWNADRSTAAGSSGKY FRAALVYAAAAACGGDVGDATPVSAAVELVHNFTLLHDDVMDGDATRRGRPTVWSVWGVGVAILLGDALH ATAVRILTGLTDECVAVRAIRRLQMSCLDLCIGQFEDCLLEGQPEVTVDDYLRMAAGKTAALTGCCCALG ALVANADDATIAALERFGHELGLAFQCVDDLIGIWGDPGVTGKPVGNDLARRKATLPVVAALNSRSEAAT ELAALYQAPAAMTASDVERATALVKVAGGGHVAQRCADERIQAAIAALPDAVRSPDLIALSQLICRREC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3383c | idsB | - | 100% (350) | POSSIBLE POLYPRENYL SYNTHETASE IDSB (POLYPRENYL TRANSFERASE) (POLYPRENYL DIPHOSPHATE SYNTHASE) |
| M. tuberculosis H37Rv | Rv3398c | idsA1 | 4e-54 | 40.74% (297) | multifunctional dimethylallyltransferase/farnesyl |
| M. tuberculosis H37Rv | Rv0562 | grcC1 | 2e-29 | 32.01% (328) | polyprenyl-diphosphate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3415c | idsB | 0.0 | 99.71% (350) | polyprenyl synthetase IdsB |
| M. gilvum PYR-GCK | Mflv_5253 | - | 5e-29 | 34.64% (280) | trans-hexaprenyltranstransferase |
| M. leprae Br4923 | MLBr_02277 | - | 8e-28 | 34.15% (284) | polyprenyl diphosphate synthase component |
| M. abscessus ATCC 19977 | MAB_3928c | - | 2e-27 | 33.22% (286) | polyprenyl-diphosphate synthase GrcC1 |
| M. marinum M | MMAR_2564 | idsB | 1e-119 | 64.64% (345) | polyprenyl synthetase IdsB |
| M. avium 104 | MAV_3884 | - | 6e-28 | 32.85% (277) | polyprenyl synthetase |
| M. smegmatis MC2 155 | MSMEG_1133 | - | 4e-29 | 35.00% (280) | bifunctional short chain isoprenyl diphosphate synthase |
| M. thermoresistible (build 8) | TH_1767 | - | 6e-29 | 33.57% (280) | bifunctional short chain isoprenyl diphosphate synthase |
| M. ulcerans Agy99 | MUL_3197 | idsB | 1e-117 | 64.06% (345) | polyprenyl synthetase IdsB |
| M. vanbaalenii PYR-1 | Mvan_0992 | - | 9e-29 | 33.93% (280) | trans-hexaprenyltranstransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5253|M.gilvum_PYR-GCK --------------------------------MRTPANVVAGVDFGDAQF
Mvan_0992|M.vanbaalenii_PYR-1 --------------------------------------MVAGVDFGDAEF
MSMEG_1133|M.smegmatis_MC2_155 --------------------------------------MVAGVDFGDPAF
TH_1767|M.thermoresistible__bu --------------------------------------VVAGVDLGDPDF
MLBr_02277|M.leprae_Br4923 -------------------------------------MVVAGINFGDAAF
MAB_3928c|M.abscessus_ATCC_199 ---------------------------------------MAGVDLGDPVF
Rv3383c|M.tuberculosis_H37Rv -------------------MGGVLTLDAAFLGSVPADLGKALLERARADC
Mb3415c|M.bovis_AF2122/97 -------------------MGGVLTLDAAFLGSVPADLGKALLERARADC
MMAR_2564|M.marinum_M -----------------------MTADGTCESDVPAEVVQLFLSSARAAC
MUL_3197|M.ulcerans_Agy99 -----------------------MTADGTCESDVPAAVVQLFLSSARAAC
MAV_3884|M.avium_104 MFGPGGTGQAVPSGRERWDTMGALSFSPTTTVAAPAWTRIDDFGGWRAHV
. .
Mflv_5253|M.gilvum_PYR-GCK AQDVRDGVARIEAL-MSEELGRADALMSEAVNHLFQAGGKRFRPLFTVLS
Mvan_0992|M.vanbaalenii_PYR-1 AQDVRDGVARIEAL-MSEELGKADVLMAEAVQHLFQAGGKRFRPLFTVLS
MSMEG_1133|M.smegmatis_MC2_155 AADVRDGVARIEDL-MSDELGKADELMAEAVQHLFQAGGKRFRPLFTVLS
TH_1767|M.thermoresistible__bu AAGVRDGVARIEDL-MSSELGKADDLMAEAVQHLFRAGGKRFRPLFTVLS
MLBr_02277|M.leprae_Br4923 AATVQDRVVRIEQL-MDAELRDTDEVMTESVLHLFAAGGKRFRPLFTVLS
MAB_3928c|M.abscessus_ATCC_199 AAKVRDHLAAIETL-IVSELGQSDPLLTESVLHLFHAGGKRFRPLFTVLA
Rv3383c|M.tuberculosis_H37Rv GPVLHRAIESMREP-LATMAGYHLGWWNADRSTAAGSSGKYFRAALVYAA
Mb3415c|M.bovis_AF2122/97 GPVLHRAIESMREP-LATMAGYHLGWWNADRSTAAGSSGKYFRAALVYAA
MMAR_2564|M.marinum_M DPVLRRAVESMPEP-LATMAGYHLGWWDIDRSALAGSSGTFVRAALVWAA
MUL_3197|M.ulcerans_Agy99 DPVLRRAVESMPEP-LATMAGYYLGWWDIDRSALAGSSGTFVRAALVWAA
MAV_3884|M.avium_104 RAMVLDEVADFVGVRRADELDRAGIGAAGDILVQFVSGGKCLRSTFVYLG
: : : :.*. .*. :. .
Mflv_5253|M.gilvum_PYR-GCK AQLGPEPDAWQVTVAGAVIELVHLATLYHDDVMDEAQVRRGAPSANARWG
Mvan_0992|M.vanbaalenii_PYR-1 AQLGPEPDAWQVTVAGAVIELVHLATLYHDDVMDEAQVRRGAPSANARWS
MSMEG_1133|M.smegmatis_MC2_155 AQLGPEPDAWQVTVAGAVIELVHLATLYHDDVMDEAQMRRGAQSANARWG
TH_1767|M.thermoresistible__bu AQLGPEPDAWQVTVAGAVIELVHLATLYHDDVMDDAEMRRGAPSANAKWG
MLBr_02277|M.leprae_Br4923 AQIGPRPDAPEVIIAGAVIELVHLASLYHDDVMDEAEVRRGAPSANLRWS
MAB_3928c|M.abscessus_ATCC_199 AQTGPDPDNDEVILAGAVCELIHLATLYHDDVMDEAQKRRGVPSANARWG
Rv3383c|M.tuberculosis_H37Rv AAACGG-DVGDATPVSAAVELVHNFTLLHDDVMDGDATRRGRPTVWSVWG
Mb3415c|M.bovis_AF2122/97 AAACGG-DVGDATPVSAAVELVHNFTLLHDDVMDGDATRRGRPTVWSVWG
MMAR_2564|M.marinum_M AAACGG-DAGNAAPIAAAVELVHSGTLLHDDVMAGEVTRGGRRAVWSIWG
MUL_3197|M.ulcerans_Agy99 AAACGG-DAGNAAPIAAAVELVHSGTLLHDDVMAGEVTRGGRRAVWSIWG
MAV_3884|M.avium_104 -WLCGAPRDRAALRAAASFELLHAFALLQDDVMDGAQERRGRPAAHLQFG
. .* **:* :* :**** * * :. :.
Mflv_5253|M.gilvum_PYR-GCK ----------------NNIAILAGDYLFATASRLTSRLG------PEAVR
Mvan_0992|M.vanbaalenii_PYR-1 ----------------NNIAILAGDYLFATASRLVSRLG------PDAVR
MSMEG_1133|M.smegmatis_MC2_155 ----------------NNIAILAGDYLFATASRLVSRLG------PDAVR
TH_1767|M.thermoresistible__bu ----------------NSIAILAGDYLFATASRLVSRLG------PEAVR
MLBr_02277|M.leprae_Br4923 ----------------NSVAILAGDYLFATASRLVSQLG------LDAVR
MAB_3928c|M.abscessus_ATCC_199 ----------------NNVAILAGDYLLATASRLVSRLG------PTAVR
Rv3383c|M.tuberculosis_H37Rv ----------------VGVAILLGDALHATAVRILTGLTDECV-AVRAIR
Mb3415c|M.bovis_AF2122/97 ----------------VGGAILLGDALHATAVRILTGLTDECV-AVRAIR
MMAR_2564|M.marinum_M ----------------IDNAILLGDALQTAAIRTLTDLPDPGV-AVRAVM
MUL_3197|M.ulcerans_Agy99 ----------------IDNAILLGDALQTAAIRTLTDLPDPGV-AVRAVM
MAV_3884|M.avium_104 RWHQDRGLSGSPRRFGESAAILLGDLCLIWAEQMLRDSGLEARRLQRAFP
. *** ** * : *.
Mflv_5253|M.gilvum_PYR-GCK IIADTFALLVTGQMRETRGAADQVDSVDHYLKVVYEKTACLIS-ASGRFG
Mvan_0992|M.vanbaalenii_PYR-1 IIADTFALLVTGQMRETRGAADHVDEVDHYLKVVYEKTACLIA-ASGRFG
MSMEG_1133|M.smegmatis_MC2_155 VIADTFAQLVTGQMRETRGAADHVDSVDHYLKVVYEKTACLIA-ASGRFG
TH_1767|M.thermoresistible__bu VIADTFAQLVTGQMRETRGAADGADPIEHYLKVVYEKTACLIS-ASGRFG
MLBr_02277|M.leprae_Br4923 IIADTFAQLVTGQMRETRGVPEGADSIEQYLKVVYEKTGCLIG-SAGRLG
MAB_3928c|M.abscessus_ATCC_199 IVAETFAELVTGQMRETVGVPEGGDETEHYLKVIHEKTGSLIA-AAGRFG
Rv3383c|M.tuberculosis_H37Rv RLQMSCLDLCIGQFEDCLLEGQPEVTVDDYLRMAAGKTAALTG-CCCALG
Mb3415c|M.bovis_AF2122/97 RLQMSCLDLCIGQFEDCLLEGQPEVTVDDYLRMAAGKTAALTG-CCCALG
MMAR_2564|M.marinum_M RLETSCLDLCIGRFEDCAFECGQAGPVDSYERMAAGKTAALIG-CCCGLG
MUL_3197|M.ulcerans_Agy99 RLETSCLDLCIGRFEDCAFECGQAGPVDSYERMAAGKTAALIG-CCCGLG
MAV_3884|M.avium_104 RYDAMRVELAVGQFADLTNDIRQSPGLDAVLEVARRKSGNYTVRRPLEIG
* *:: : : .: *:. :*
Mflv_5253|M.gilvum_PYR-GCK ATFSGSDEAQIERLAKLGGIVGTAFQISDDIIDIDSDADESGKVPGTDLR
Mvan_0992|M.vanbaalenii_PYR-1 ATFSGADDEQIERLARLGGIVGTAFQISDDIIDIDSDPDESGKVPGTDLR
MSMEG_1133|M.smegmatis_MC2_155 ATFSGANDEQIERLSRLGGIVGTAFQIADDIIDIDSDPDESGKTPGTDLR
TH_1767|M.thermoresistible__bu ATFSGADEEQVERLARLGGIVGTAFQISDDIIDIESESTESGKTPGTDLR
MLBr_02277|M.leprae_Br4923 GLFAGAHAEQVERLSRLGSIVGTAFQISDDIIDIDSDYTKSGKLPGTDVR
MAB_3928c|M.abscessus_ATCC_199 AMTSRCDDDQIERLSRLGAIVGTAFQISDDIIDIESLTDESGKTPGTDLR
Rv3383c|M.tuberculosis_H37Rv ALVANADDATIAALERFGHELGLAFQCVDDLIGIWGDPGVTGKPVGNDLA
Mb3415c|M.bovis_AF2122/97 ALVANADDATIAALERFGHELGLAFQCVDDLIGIWGDPGVTGKPVGNDLA
MMAR_2564|M.marinum_M ALAADAGDATIAALERFGRELGLAFQCVN------------------DLG
MUL_3197|M.ulcerans_Agy99 ALAADAGDATITALERFGRELGLAFQCVN------------------DLG
MAV_3884|M.avium_104 ATMAGCDDRTVARLSRYGAAVGEAFQLRDDVLGVFGSPAVTGKPCAADLF
. : . : * : * :* *** : *:
Mflv_5253|M.gilvum_PYR-GCK EGVHTLPVLYALRETGPDADRLRELLAG-PVTDDADVAEALRLLRGSQGI
Mvan_0992|M.vanbaalenii_PYR-1 EGVHTLPVLYALRETGPDADRLRELLAT-PVTDDGDLAEALRLLRASDGI
MSMEG_1133|M.smegmatis_MC2_155 EGVHTLPVLYALRETGPDADRLRELLAG-PIERDEDVAEALALLRRSPGL
TH_1767|M.thermoresistible__bu EGVHTLPVLYALRETGPEAERLRELVSR-PVEDDADLAEALDLLRRSPGM
MLBr_02277|M.leprae_Br4923 EGVRTLPILYALRETGPDSERLRALLAG-PVDNDAEVVEALALLRASPGM
MAB_3928c|M.abscessus_ATCC_199 EGVHTLPMLYALRDTGPDADRLRVLLAA-PITDDAEVEEALALLRASEGL
Rv3383c|M.tuberculosis_H37Rv RRKATLPVVAALNSRSEAATELAALYQAPAAMTASDVERATALVKVAGGG
Mb3415c|M.bovis_AF2122/97 RRKATLPVVAALNSRSEAATELAALYQAPAAMTASDVERATALVKVAGGG
MMAR_2564|M.marinum_M RRNATLTVAAALNSRSDAAIEPAALCHSGSFMATGDIDRAATLVDVAAGR
MUL_3197|M.ulcerans_Agy99 RRNATLTVAAALNSRSEAAIEPAALCHSGSFMATGDIDRAATLVDVAAGR
MAV_3884|M.avium_104 ERKATAVVVSAHQLADPPVRRELIELATRDVLDAAAIERWKALIVETGAV
. * : * . . . : . *: : .
Mflv_5253|M.gilvum_PYR-GCK RKAKETVIGYAQEAQRELDQLPDVPGRQALASLVDYTVNRHG-
Mvan_0992|M.vanbaalenii_PYR-1 TKAKETVAAYAREAEQELGQLPAGPGRQALATLVQYTINRHG-
MSMEG_1133|M.smegmatis_MC2_155 TKAKETVASYAAQAREELSHLPECPGRQALAVLVDYTISREG-
TH_1767|M.thermoresistible__bu AQATETVREYATEARSVLAQLPAGPGRDALATLIDFTVNRHG-
MLBr_02277|M.leprae_Br4923 ARARQVLAHYADQASGELAQLPDGPSRDALATLVDYTTNRHG-
MAB_3928c|M.abscessus_ATCC_199 AQAKSVVIDYADRAKAELVELPPGDARDALGVLIEYTVRRHG-
Rv3383c|M.tuberculosis_H37Rv HVAQRCAD---ERIQAAIAALPDAVRSPDLIALSQLICRREC-
Mb3415c|M.bovis_AF2122/97 HVAQRCAD---ERIQAAIAALPDAVRSPDLIALSQLICRREC-
MMAR_2564|M.marinum_M HAEQRCAD---QRIQATVAALPDAVRSRDLIALSQLICRRER-
MUL_3197|M.ulcerans_Agy99 HAVQRCAD---QRIQATVAALPDAVRSRDLIALSQLICCRER-
MAV_3884|M.avium_104 RLIERMISDRVASAREQLCGLPVDESVRAALAEMAAVCTDRAE
: ** .