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DAAAPSAVELVNAVNEELREYLRGRRRDAAYIGTDYAVLTEALEEFVLRGGKRLRPAFAYWGFRAVAGTE PEPHIMRLFSALELLHACALVHDDLIDASATRRGLPTVHRIFSERHRSNNWLGSSDQFGLSAAILLGDLS LVWADDIIAEAPIDDAAHRRVQRVWAAIRTEVLGGQYLDIVNEASGSETVASALTVNIYKTASYTISRPL QLGAAAAGDRPEILEAFHELGTSLGVAFQLRDDVLGVYGDPAVTGKPSGDDLRSGKRTVLLAEAVELADR HDPPAAQLLRTSIGTDLSDAQVKELCLVIEAVGALAAVESRIDTLTRRALDIMNSAPIDVRAKAGLAELA RLAANRSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2975 | - | - | 100% (359) | polyprenyl synthetase |
| M. gilvum PYR-GCK | Mflv_1848 | - | 1e-54 | 39.62% (318) | polyprenyl synthetase |
| M. gilvum PYR-GCK | Mflv_5253 | - | 8e-21 | 26.69% (326) | trans-hexaprenyltranstransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2195 | idsA2 | 1e-127 | 67.05% (352) | geranylgeranyl pyrophosphate synthetase |
| M. tuberculosis H37Rv | Rv2173 | idsA2 | 1e-127 | 67.05% (352) | geranylgeranyl pyrophosphate synthetase |
| M. leprae Br4923 | MLBr_02277 | - | 4e-24 | 27.49% (331) | polyprenyl diphosphate synthase component |
| M. abscessus ATCC 19977 | MAB_1992c | - | 1e-103 | 59.68% (315) | polyprenyl synthetase |
| M. marinum M | MMAR_3208 | idsA2 | 1e-124 | 66.47% (340) | geranylgeranyl pyrophosphate synthetase IdsA2 |
| M. avium 104 | MAV_2321 | - | 1e-131 | 68.19% (349) | polyprenyl synthetase |
| M. smegmatis MC2 155 | MSMEG_4240 | - | 1e-144 | 72.10% (362) | polyprenyl synthetase |
| M. thermoresistible (build 8) | TH_0708 | idsA2 | 1e-148 | 74.86% (354) | PROBABLE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA2 |
| M. ulcerans Agy99 | MUL_3516 | idsA2 | 1e-121 | 65.59% (340) | geranylgeranyl pyrophosphate synthetase IdsA2 |
| M. vanbaalenii PYR-1 | Mvan_3536 | - | 1e-177 | 87.74% (359) | polyprenyl synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2195|M.bovis_AF2122/97 ----------MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLG
Rv2173|M.tuberculosis_H37Rv ----------MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLG
MAV_2321|M.avium_104 ----------MTGAITEQLRRYLHDRRAETAYIGDDYSGLIAALEEFVLN
MMAR_3208|M.marinum_M ----------------------MRDRRSQAAYIGDDYGALTAWLEEFVLS
MUL_3516|M.ulcerans_Agy99 ----------------------MRDRRSQAAYIGDDYGALTAWLEEFVLS
Mflv_2975|M.gilvum_PYR-GCK MDAAAPSAVELVNAVNEELREYLRGRRRDAAYIGTDYAVLTEALEEFVLR
Mvan_3536|M.vanbaalenii_PYR-1 MDASAPSAVELAAAVTEQLRDYLRARRRDAAYIGAGYAVLTEAVEEFVLR
TH_0708|M.thermoresistible__bu --------VELANAVTDELRDYLRQRREDSAYIGSDYTHMTAALEEFVLR
MSMEG_4240|M.smegmatis_MC2_155 MDTAAPSAVELAGAVTEQLREYLRERRSDCAYIGPVYAELTAGVEEFVLR
MAB_1992c|M.abscessus_ATCC_199 -----------------------------------------------MLR
MLBr_02277|M.leprae_Br4923 -MVVAGINFGDAAFAATVQDRVVRIEQLMDAELRDTDEVMTESVLHLFAA
.
Mb2195|M.bovis_AF2122/97 GGKRLRPLFAYWGWHAVAS-REP--DPDVLLLFSALELLHAWALVHDDLI
Rv2173|M.tuberculosis_H37Rv GGKRLRPLFAYWGWHAVAS-REP--DPDVLLLFSALELLHAWALVHDDLI
MAV_2321|M.avium_104 GGKRLRPAFAYWGWRAVAT-EAP--DDQALLLFSALELLHACALVHDDVI
MMAR_3208|M.marinum_M GGKRLRPIFAYRGWQAVTT-EDP--DPDLLLLFSALELLHAWALIHDDVI
MUL_3516|M.ulcerans_Agy99 GGKRLRPIFAYRGWPAVTT-EDP--DPDLLLLFSALELLHAWALIHDDVI
Mflv_2975|M.gilvum_PYR-GCK GGKRLRPAFAYWGFRAVAG-TEP--EPHIMRLFSALELLHACALVHDDLI
Mvan_3536|M.vanbaalenii_PYR-1 GGKRLRPAFAYWGWRAVAG-TEP--GPEALRLFSALELLHACALVHDDVI
TH_0708|M.thermoresistible__bu GGKRIRPAFAYWGWRAVAD-EPAPVPPEIMRLFAALELLHACALVHDDVI
MSMEG_4240|M.smegmatis_MC2_155 GGKRVRPAFAYWGWRSVIEPADAVAGPDVLRLFSALELLQACALIHDDVI
MAB_1992c|M.abscessus_ATCC_199 GGKRLRPAFAYWGWRAITDDPDP-WNPEVLRVCAALELLHTCALIHDDVI
MLBr_02277|M.leprae_Br4923 GGKRFRPLFTVLSAQIGPRPDAP----EVIIAGAVIELVHLASLYHDDVM
****.** *: . . . : :.:**:: :* ***::
Mb2195|M.bovis_AF2122/97 DRSATRRGRPTAQLRYAALHRDRDWRGSPDQFGMSAAILLGDLAQVWADD
Rv2173|M.tuberculosis_H37Rv DRSATRRGRPTAQLRYAALHRDRDWRGSPDQFGMSAAILLGDLAQVWADD
MAV_2321|M.avium_104 DDSATRRGRPTTHVRFASLHRDRQWQGSPERFGMSAAILLGDLALAWADD
MMAR_3208|M.marinum_M DASSTRRGRPTAHMHFAALHRDRNWLGPAQQFGISAAILIGDVAQAWADD
MUL_3516|M.ulcerans_Agy99 DASSTRRGRPMAHIHFAALHRDRNWLGPAQQFGISAAILIGDVAQAWADD
Mflv_2975|M.gilvum_PYR-GCK DASATRRGLPTVHRIFSERHRSNNWLGSSDQFGLSAAILLGDLSLVWADD
Mvan_3536|M.vanbaalenii_PYR-1 DASATRRGLPTVHRIFAERHRSNNWLGSSEQFGLSAAILLGDVALVWADD
TH_0708|M.thermoresistible__bu DASATRRGLPTVHRLFADTHRSRGWRGSAEQFGLSAAILLGDLALVWADD
MSMEG_4240|M.smegmatis_MC2_155 DDSATRRGLPTVHRLFTEQHHERGWLGSERQFGLSAAILAGDLALSWADD
MAB_1992c|M.abscessus_ATCC_199 DSSATRRGEPTIHVEFAALHRENGWSGSPEQFGISAAILLGDLALTWADD
MLBr_02277|M.leprae_Br4923 DEAEVRRGAPSANLRWSN----------------SVAILAGDYLFATASR
* : .*** * : :: *.*** ** *.
Mb2195|M.bovis_AF2122/97 IVSKVCQSALAPDAQRRVHRVWADIRNEVLGGQYLDIVAEASAAESIESA
Rv2173|M.tuberculosis_H37Rv IVSKVCQSALAPDAQRRVHRVWADIRNEVLGGQYLDIVAEASAAESIESA
MAV_2321|M.avium_104 IVLGV---DLTPQAARRVRRVWANIRTEVLGGQYLDIVAEASAAASIASA
MMAR_3208|M.marinum_M IISRVSQSSLSPDAQRRVQRVWSDIRTEVLGGQYLDIVAEASAADSITSA
MUL_3516|M.ulcerans_Agy99 IISRVSQSSLSPDAQRRVQRVWSDIRTEVLGGQYLDIVAEASAADSITSA
Mflv_2975|M.gilvum_PYR-GCK IIAEA---PIDDAAHRRVQRVWAAIRTEVLGGQYLDIVNEASGSETVASA
Mvan_3536|M.vanbaalenii_PYR-1 IVASA---EIGVEAHRRVQRVWAAIRTEVLGGQYLDIVNEATGAETVASA
TH_0708|M.thermoresistible__bu AVGSA---GLSVDAHRRVRRVWADIRTEVLGGQYLDIVNESSGADSVASA
MSMEG_4240|M.smegmatis_MC2_155 IVAGA---DLPVDAHRRVQTVWRHIRTEVLGGQYLDIVTESSGDESVASA
MAB_1992c|M.abscessus_ATCC_199 MVVGA---QLSPEAHVRARGVWSILRSEVLGGQYLDILSESSGDESVETA
MLBr_02277|M.leprae_Br4923 LVSQLG---------LDAVRIIADTFAQLVTGQMRETRGVPEGADSIEQY
: . : ::: ** : . . ::
Mb2195|M.bovis_AF2122/97 MNVATLKTACYTVSRPLQLGTAAAADRSDVAAIFEHFGADLGVAFQLRDD
Rv2173|M.tuberculosis_H37Rv MNVATLKTACYTVSRPLQLGTAAAADRSDVAAIFEHFGADLGVAFQLRDD
MAV_2321|M.avium_104 MNVDTFKTACYTVSRPLQLGAAAAADRPDVHDLFSQFGTDLGVAFQLRDD
MMAR_3208|M.marinum_M MTVATFKTACYTVSRPLQLGAAAAADRPDVQEAFHQFGTDLGVAFQLRDD
MUL_3516|M.ulcerans_Agy99 MTVATFKTACYTVSRPLQLGAAAAADRPDVQEAFHQFGTDLGVAFQLRDD
Mflv_2975|M.gilvum_PYR-GCK LTVNIYKTASYTISRPLQLGAAAAGDRPEILEAFHELGTSLGVAFQLRDD
Mvan_3536|M.vanbaalenii_PYR-1 LTVNIYKTASYTISRPLQLGAAAAADCPEVLSAFHELGTSLGVAFQLRDD
TH_0708|M.thermoresistible__bu MTVNTYKTASYTVTRPLQLGAAAAADRPDVLATFHEVGNDLGVAFQLRDD
MSMEG_4240|M.smegmatis_MC2_155 LNVNTFKTASYTVARPLQLGAAAAADRPDVQELFHRIGNDLGVAFQLRDD
MAB_1992c|M.abscessus_ATCC_199 LRVIRFKTAGYTVQRPLQLGVAIAGENAEISRLLGDVGLDIGIAFQLRDD
MLBr_02277|M.leprae_Br4923 LKVVYEKTGCLIGS-AGRLGGLFAGAHAEQVERLSRLGSIVGTAFQISDD
: * **. . :** *. .: : .* :* ***: **
Mb2195|M.bovis_AF2122/97 VLGVFGDPAVTGKPSGDDLKSGKRTVLVAEAVELADRSDPLAAKLLRTSI
Rv2173|M.tuberculosis_H37Rv VLGVFGDPAVTGKPSGDDLKSGKRTVLVAEAVELADRSDPLAAKLLRTSI
MAV_2321|M.avium_104 VLGVFGDPAVTGKPSGDDLRSGKRTVLLAEAVELAEKSDPLAAKLLRDSI
MMAR_3208|M.marinum_M VLGVFGDPAVTGKPSGDDLRSGKRTVLIAEAAALADRSDPKAANLLRSAV
MUL_3516|M.ulcerans_Agy99 VLGVFGDPAMTGKPSGDDLRSGKRTVLIAEAAALADRSDPKAANLLRSAV
Mflv_2975|M.gilvum_PYR-GCK VLGVYGDPAVTGKPSGDDLRSGKRTVLLAEAVELADRHDPPAAQLLRTSI
Mvan_3536|M.vanbaalenii_PYR-1 VLGVFGDPAVTGKPSGDDLRSGKRTVLLAEAVELAEKHDQIAAKLLRTSI
TH_0708|M.thermoresistible__bu VLGVFGDPAVTGKPSGDDLRSGKRTVLLAEAVELAEQRDPAAAELLRTAI
MSMEG_4240|M.smegmatis_MC2_155 VLGVFGDPAVTGKPSGDDLRSGKRTVLLAEALELADASDPAAAALLRRSV
MAB_1992c|M.abscessus_ATCC_199 VLGVFGDPKVTGKPAGDDLRSGKRTVLLAEALRLARQRDSAAEDLLHSWI
MLBr_02277|M.leprae_Br4923 IIDIDSDYTKSGKLPGTDVREGVRTLPILYALRETG---PDSERLRALLA
::.: .* :** .* *::.* **: : * : : *
Mb2195|M.bovis_AF2122/97 GTRLTDAQVRELRTVIEAVGARAAAESRIAALTQRALATLASAPINATAK
Rv2173|M.tuberculosis_H37Rv GTRLTDAQVRELRTVIEAVGARAAAESRIAALTQRALATLASAPINATAK
MAV_2321|M.avium_104 GAQLSDAEVDRLRDVIESVGALAAAEQRIATLTQRALATLAAAPINTAAK
MMAR_3208|M.marinum_M GSELTDSQVGELREVIVRVGALAAAENRIAGLTRRALATLESIPINASAK
MUL_3516|M.ulcerans_Agy99 GSELTDSQVGELREVIVRVGALAAAENRNAGLTRRALATLESIPINASAK
Mflv_2975|M.gilvum_PYR-GCK GTDLSDAQVKELCLVIEAVGALAAVESRIDTLTRRALDIMNSAPIDVRAK
Mvan_3536|M.vanbaalenii_PYR-1 GTDLTDAQVKEVCLVIESVGALAAVESRIDTLTRRALDILNSAPIDVQAK
TH_0708|M.thermoresistible__bu GTELSDEQVTEVCGAIEKVGALRAVEDRIETLTTRALRRLDAAPIHEAAK
MSMEG_4240|M.smegmatis_MC2_155 GTELSDTQVRELCDAIESVGALAAVEQRIETLTRDALDVLAAANVHPQAK
MAB_1992c|M.abscessus_ATCC_199 GTPLTDQQVAEMCSLIVDLGALGAVESRIEEHTHRALDQLAGADIADDAR
MLBr_02277|M.leprae_Br4923 GPVDNDAEVVEALALLRASPGMARARQVLAHYADQASGELAQLP-DGPSR
*. .* :* . : . ... : * : ::
Mb2195|M.bovis_AF2122/97 AGLSELAMMAANRSA
Rv2173|M.tuberculosis_H37Rv AGLSELAMMAANRSA
MAV_2321|M.avium_104 AGLSELAKLATNRSA
MMAR_3208|M.marinum_M AGLSALARTATDRSA
MUL_3516|M.ulcerans_Agy99 AGLSALARTATDRSA
Mflv_2975|M.gilvum_PYR-GCK AGLAELARLAANRSA
Mvan_3536|M.vanbaalenii_PYR-1 AGLAELARMAANRSA
TH_0708|M.thermoresistible__bu VGLSELARSAANRSA
MSMEG_4240|M.smegmatis_MC2_155 AGLSELARSAANRTA
MAB_1992c|M.abscessus_ATCC_199 AALSDLVRLVSNRSA
MLBr_02277|M.leprae_Br4923 DALATLVDYTTNRHG
.*: *. .::* .