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APLSVDPEALSGAGSAVAAAGDALAAALSSLTTGFSANTGQDAAGEVFGLAYQDAAESLVKAAGAGINAL RHNGAKIQLSASNYSAAEAASTLGGGAGVLPAPSEPAQFTAPGAPGTLGSGVLAPALWSVVEAFVGDLWP NGDVAGLHAAAGHWRDFAAALNGVQGALNSPKSVVAGQDIPEGAQIQQVLSAIGSDLAGVGAQCQKLAGA LDDFADEVADTQDAIRDLLDRFGSVSGLWNQVMAIFEGDALDEIKEIAEDIQAVLSNLGRQARAQQQLMQ QGMQAIDGLVVGMQRYVRGQLTQFLGQDVGNPLATVFDTYTNTQEGVFKAAVGMVEGIEQLNPQRFLIDP QGAAETWKAMTKTGLINHLLNPEEAVAADKEMVKGLLHLEDWRRDRPGLGFGGNLFDVATLFVPGAGGAG AGAKGAAGAARAAEVGGEAADAAAAVGRGGRLAGEVGDLAGAGRTLGDIGKTGRGLTEDLANLGGDLPKA DPPVGGRPVALPPPKPAGAPAEPTPRPVESVPPGKPALEAPSGAPGSVVPGRSEPAFGPHDPASAPVAGS HPAATAVTPGERVSPVTPHVGEPARAPGVPVGAAAGPVPAGAHSAPAAIPAAPGAHVMTGAGRPAELSAP HGGVPQGLGDAGPSGGHPHGLPPHGGGPHGPGDASHGARHAEPPRDGTAHGTADGGDAHGDDVSGHGLSA EKRDEIIAMPKGSRPDPSEYLSPEYIQGHLDRFTDGATRFMPESNLDKYGIAQRDGTSFVMPKSEADAMI AGTGGDLRLMEEELGLPEGFLDSNQIVRIDIEDPRQFNLRIPSGNEAGANEQWIPGGRLPTGASEAVVDG GKIPQGDYTVTDVFEEK*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3072 | - | - | 100% (858) | hypothetical protein MMAR_3072 |
M. marinum M | MMAR_5464 | - | 2e-66 | 29.90% (719) | ADP-ribosyltransferse |
M. marinum M | MMAR_5455 | - | 1e-19 | 32.41% (253) | hypothetical protein MMAR_5455 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3933c | - | 3e-68 | 31.32% (763) | hypothetical protein Mb3933c |
M. gilvum PYR-GCK | Mflv_3843 | - | 3e-19 | 36.36% (286) | hypothetical protein Mflv_3843 |
M. tuberculosis H37Rv | Rv3903c | - | 3e-68 | 31.32% (763) | hypothetical protein Rv3903c |
M. leprae Br4923 | MLBr_02591 | mce1C | 4e-06 | 27.18% (206) | putative secreted protein |
M. abscessus ATCC 19977 | MAB_3131c | - | 1e-13 | 31.25% (208) | translation initiation factor IF-2 (InfB) |
M. avium 104 | MAV_2415 | - | 1e-164 | 44.53% (786) | hypothetical protein MAV_2415 |
M. smegmatis MC2 155 | MSMEG_1870 | - | 2e-61 | 28.77% (702) | hypothetical protein MSMEG_1870 |
M. thermoresistible (build 8) | TH_3868 | - | 1e-27 | 27.85% (298) | PUTATIVE putative conserved hypothetical protein |
M. ulcerans Agy99 | MUL_2318 | - | 0.0 | 98.25% (858) | hypothetical protein MUL_2318 |
M. vanbaalenii PYR-1 | Mvan_2314 | infB | 1e-15 | 33.81% (210) | translation initiation factor IF-2 |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_3072|M.marinum_M --------------MAPLSVDPEALSGAGSAVAAAGDALAAALSSLTTGF MUL_2318|M.ulcerans_Agy99 --------MGKNPGVAPLSVDPEALSGAGSAVAAAGDALAAALSSLTTGF MAV_2415|M.avium_104 --------------MAPLAVDPEAMYAAGSAVAAIGDSLAANLTILTAGV Mb3933c|M.bovis_AF2122/97 --------------MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAAL Rv3903c|M.tuberculosis_H37Rv --------------MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAAL MSMEG_1870|M.smegmatis_MC2_155 --MPSNSGGGGGVSGIRIEVDPQVLIRAGESMLSLGNQLDMLMGALGPML TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -----------MAGKARVHELAKELGVTSKEVLARLSDQGEFVKSASSTV Mvan_2314|M.vanbaalenii_PYR-1 -----------MAGKARVHELAKELGVTSKEVLARLSEQGEFVKSASSTV MLBr_02591|M.leprae_Br4923 ------------------------MRTLELPNRLRSGLIGVLVVLLIIGV Mflv_3843|M.gilvum_PYR-GCK MSRTKKSIVVVMMGSAGLFLSAPLLGPAANATPTRGGVPCVGILQQIVTR MMAR_3072|M.marinum_M S---ANTGQDAAGEVFGLAYQDAAES------LVKAAGAGINALRHNGAK MUL_2318|M.ulcerans_Agy99 S---ANTGQDTAGEVFGLAYQDAAES------LVKAAGAGINALRHNGAK MAV_2415|M.avium_104 S---AHTGVDRAGEVFGLGYQDSAES------MLKAAAGVVNACRKCGAL Mb3933c|M.bovis_AF2122/97 AGCAGMAGDDPAGAVFGRSYDGSAAA------LVQAMSVARNGLCNLGDG Rv3903c|M.tuberculosis_H37Rv AGCAGMAGDDPAGAVFGRSYDGSAAA------LVQAMSVARNGLCNLGDG MSMEG_1870|M.smegmatis_MC2_155 SSG-IASGIDLAGLAMALDYGDLTQK------FSNTLANGANTFKTVGLR TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 EAPVARRLRESFGGG--DKPAPAASN----GAAAEAAAPPKKAGPKPGAP Mvan_2314|M.vanbaalenii_PYR-1 EAPVARRLRESYGGSKSDKTKAAPSGNGAAGATVKPSAPQSRPGPKPGP- MLBr_02591|M.leprae_Br4923 GQSFTSVPILFARPSYYGQFTDTGGLN-------------------KGDK Mflv_3843|M.gilvum_PYR-GCK PGEIPQALTDTARSFTEPPKPAPPVVRPPASSSSSAGTPPVPGRPPASVV MMAR_3072|M.marinum_M IQLSASNYSAAEAASTLGGGAGVLPAP-SEPAQFTAPGAPGTLGSGVLAP MUL_2318|M.ulcerans_Agy99 IQLSASNYSAAEAASTLGGGAGVLPAP-SEPAQFTAPGAPGTLGSGVLAP MAV_2415|M.avium_104 IQQGASNYSAAEAASTLGGGSGALPAP-SAPADLAAPGPPGTWGKGEPPP Mb3933c|M.bovis_AF2122/97 VRMSAHNYSLAEAMSDVAGRAAPLPAP-PPSGCVGVGAPPSAVGGGGGAP Rv3903c|M.tuberculosis_H37Rv VRMSAHNYSLAEAMSDVAGRAAPLPAP-PPSGCVGVGAPPSAVGGGGGAP MSMEG_1870|M.smegmatis_MC2_155 LQASGHNYANADAVSTIGGGAPTGGVKGKFDETKPVDARDSPSLSVVPPP TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 KPAPKKVAEPVVEAPVAPEPPAAPAAPAAPAPKPSPAARPAAAEAAAPAP Mvan_2314|M.vanbaalenii_PYR-1 -PVAQQPAAPAAPPAAPPAPPTPAAAPPSPAPAAPAAATPAEPAAPSARP MLBr_02591|M.leprae_Br4923 VRIAGMDVGKVEALKIDG-------------------------------- Mflv_3843|M.gilvum_PYR-GCK TPSSGATPPVPPSPGTPASTSTRGGTPPVPPAPPAPAGTPASGATPPAPP MMAR_3072|M.marinum_M ALWSVVEAFVG------------DLWPNGDVAGLHAAAGHWRDFAAALNG MUL_2318|M.ulcerans_Agy99 ALWSVVEAFVG------------DLWPNGDVAGLHAAAGHWRDFAAALNG MAV_2415|M.avium_104 LLWAVIQALVS------------EVWPDGDEAGLHAAASRWHGFAAAMNG Mb3933c|M.bovis_AF2122/97 KGWGWVAPYIG------------MIWPNGDSTKLRAAAVAWRSAGTQFAL Rv3903c|M.tuberculosis_H37Rv KGWGWVAPYIG------------MIWPNGDSTKLRAAAVAWRSAGTQFAL MSMEG_1870|M.smegmatis_MC2_155 PAWYLVGSFLGP-----------TAWPSGNPAMLRLTAAQWENLATGFSA TH_3868|M.thermoresistible__bu --------------------------------MLRLTVAQWRNFAHGFAV MAB_3131c|M.abscessus_ATCC_199 APAPAPRPGATP-----------GPKPGAP----RVPRVGNNPFSSAQPA Mvan_2314|M.vanbaalenii_PYR-1 GPTPGPRPGPS------------APKPGAPKPAARTPRVGNNPFSSQQPV MLBr_02591|M.leprae_Br4923 -DHVVIKFSIGT-----------NRIGTASRLGIRTDTVLGKKVLEVETR Mflv_3843|M.gilvum_PYR-GCK VPGVPAVTSTGGGTPPVPPVPGAPVGAPVANPGLPTPPVPGAPVFGDGGA MMAR_3072|M.marinum_M VQGALNS-PKSVVAGQD---IPEGAQIQQVLSAIGSDLAGVGAQCQKL-A MUL_2318|M.ulcerans_Agy99 VQGALNS-PKSVVAGQD---IPEGVQIQQVLSAIGSDLAGVGAQCRKL-A MAV_2415|M.avium_104 VQGTLNA-SKALFDSQQ---IPEGEKIDHALAEIGAAAAAIGQQCDAL-A Mb3933c|M.bovis_AF2122/97 TEIQSTAGPMGVIRAQQ---LPEAGLIESAFADAYASTTAVVGQCHQL-A Rv3903c|M.tuberculosis_H37Rv TEIQSTAGPMGVIRAQQ---LPEAGLIESAFADAYASTTAVVGQCHQL-A MSMEG_1870|M.smegmatis_MC2_155 VSNQVSG-SSTAVSTQK---IPEASQIAQAHADLADGVADLANQATNL-A TH_3868|M.thermoresistible__bu FEPQLAP-VLAVVSAQN---TPETPAIVSGLDELARGISALTDASVEV-A MAB_3131c|M.abscessus_ATCC_199 ERPAPRPQAP---RPG----APRPGG-----ASPSNMPPRPSPGSMGP-R Mvan_2314|M.vanbaalenii_PYR-1 ERPAPRPQGPGGPRPGPGAGGPRPGGGPRPGASPGSMPPRPQ-GARPG-G MLBr_02591|M.leprae_Br4923 GTQLLRPGDSLPLGQSTTPYQSYDAFFDATKVASGWNIDTIKQSLKVV-S Mflv_3843|M.gilvum_PYR-GCK VLPPLPPAPAGPAGGPAGLVAPPAPPVPGGPAAVPAGVALPPAPPGAPGA . MMAR_3072|M.marinum_M GALDDFADEVADTQDAIRDLLDRFGSVSGLWNQVMAIFEGDAL------- MUL_2318|M.ulcerans_Agy99 GALDDFADEVADTQDAIRDLLDRFGSVSGLWNQVVAIFEGDAL------- MAV_2415|M.avium_104 RTVDEFADRVGHAQQAIRDLLHRIEALGDIGHDIMLIIDGDAW------- Mb3933c|M.bovis_AF2122/97 AQLDAYAARIDAVHAAVLDLLARICDPLTGIKEVWEFLTDQDE------- Rv3903c|M.tuberculosis_H37Rv AQLDAYAARIDAVHAAVLDLLARICDPLTGIKEVWEFLTDQDE------- MSMEG_1870|M.smegmatis_MC2_155 ETLNTFADNVQETQDAIRRLLDRVASIDGIINTVKGIFTGDAL------- TH_3868|M.thermoresistible__bu REVEDFAATVQGTQDAIRRLVGRVS-ISGLFHTVKGILTGDGK------- MAB_3131c|M.abscessus_ATCC_199 PPRPGGGPRPGGGPR--PGGAGRPGGGGGG--NYRGGGTGTGAPAGGPPG Mvan_2314|M.vanbaalenii_PYR-1 GPRPGGGPRPGGGPRPTPGGAGRPGGGGGGGGNYRGGGAGGGAPAAG--- MLBr_02591|M.leprae_Br4923 ETIDQTYPHLSAALDGVAKFSDTIGARDKEIKHLIAQAN----------- Mflv_3843|M.gilvum_PYR-GCK PVFGEAGAAPSGAAAPVAPAAGSGGAGGAGGGSGIGGPGGGGAPVEGTGG MMAR_3072|M.marinum_M ----DEIKEIAEDIQAVLSNLGRQARAQQQLMQQGMQAIDGLVVGMQRYV MUL_2318|M.ulcerans_Agy99 ----DEIKEIAEDIRAVLSNLGRQARAQQQLMQQGMQAIDGLVVGMQRYV MAV_2415|M.avium_104 ----DEIQKIARDVNAVLQHLGQEARAFEQEIRLLMQAADREIVTCQKYA Mb3933c|M.bovis_AF2122/97 ----DEIQRIAHDIAVVVDQFSGEVDALAAEITAVVSHAEAVITAMADHA Rv3903c|M.tuberculosis_H37Rv ----DEIQRIAHDIAVVVDQFSGEVDALAAEITAVVSHAEAVITAMADHA MSMEG_1870|M.smegmatis_MC2_155 ----DIIKEVVEDIRTLLGNFQRQVKAVGALLEELKNALNDTVTKFQKWA TH_3868|M.thermoresistible__bu ----DILREVARDVRTVLDNFQRQVKGVIGLLEELATLIGDAATAFQKWL MAB_3131c|M.abscessus_ATCC_199 AGGGFRGRPGGGGGGGRPGQRGGAAGAFGRPGGAPKRGRKSKRAKRAEYE Mvan_2314|M.vanbaalenii_PYR-1 -GGGFRGRPGGGGGGGRPGQRGGAAGAFGRPGGAPKRGRKSKRAKRAEYE MLBr_02591|M.leprae_Br4923 -----QVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAAFA Mflv_3843|M.gilvum_PYR-GCK AVPAGAPLAAAGGEVPPPAPPIPGAPVIGEAGVVPPPAPPAPAPPAGGLG . . MMAR_3072|M.marinum_M RGQLTQFLGQDVGNPLATVFDTY----------TNTQEGVFKAAVGMVEG MUL_2318|M.ulcerans_Agy99 RGQLTQLLGQDVGNPVATVFDTY----------TNTQEGVFKAAVGMVEG MAV_2415|M.avium_104 RRGLITFLGEDVGNPVATALDFG----------INVQEGVVKGAVGMGLG Mb3933c|M.bovis_AF2122/97 GKQWDRFLHS---NPVGVVIDGT----------GQQLKGFGEEAFGMAKD Rv3903c|M.tuberculosis_H37Rv GKQWDRFLHS---NPVGVVIDGT----------GQQLKGFGEEAFGMAKD MSMEG_1870|M.smegmatis_MC2_155 DKNLREILGDQVGGAISDIIKFQ----------TDLSTGVLNGVINTVAG TH_3868|M.thermoresistible__bu RPNLVAVFGEQVGGAMADRIELR----------TDLGVGVVTGLIGTVTG MAB_3131c|M.abscessus_ATCC_199 NMQAPVVGGVRLPHGNGEVIRLARGAS-----LSDFAEKIDANPASLVQA Mvan_2314|M.vanbaalenii_PYR-1 NMQAPVVGGVRLPHGNGETIRLARGAS-----LSDFAEKINANPASLVQA MLBr_02591|M.leprae_Br4923 AQVQRLINDNPNLNHVLEQLHQL----------SGILVQHKDDLANTLIQ Mflv_3843|M.gilvum_PYR-GCK GAVPPPVPGAPGVPVVDEAGVVTPPAPGGPGVPTGGEGGVVTPPAPGAPG . MMAR_3072|M.marinum_M IEQLNPQRFLIDPQGAAETWKAMTK----TGLINH-------LLNPEEAV MUL_2318|M.ulcerans_Agy99 IEQLNPQRFLIDPQGAAETWKAMTK----TGLINH-------LLNPEEAV MAV_2415|M.avium_104 LVDLSPHWIALDPEGAGATWGGLVKNAWKESFVNA-------AVNPQEFA Mb3933c|M.bovis_AF2122/97 SWDLGPLRASIDPFGWYRSWEEMLTGMAPLAGLGG-------ENAPG-VV Rv3903c|M.tuberculosis_H37Rv SWDLGPLRASIDPFGWYRSWEEMLTGMAPLAGLGG-------ENAPG-VV MSMEG_1870|M.smegmatis_MC2_155 TVAFAD----------FDTWKGLGE-----TALAV-------IKDPSLID TH_3868|M.thermoresistible__bu VVALAD----------ADTWRGLAN-----LALTV-------GPDPTKMP MAB_3131c|M.abscessus_ATCC_199 LFNLGEMVTATQSVG-DETLELLGGEMNYVVQVVSPE-----DEDRELLE Mvan_2314|M.vanbaalenii_PYR-1 LFNLGEMVTATQSVG-DETLELLGGEMNYVVQVVSPE-----DEDRELLE MLBr_02591|M.leprae_Br4923 VAAFLP-----------SLNEAIGSGPFFKVVLHN--------LAPYQIL Mflv_3843|M.gilvum_PYR-GCK VPVVDEAGVVTPPAPGGPGVPTGGEGGVVTPPAPGAPGAPVVDEAGVVTP . MMAR_3072|M.marinum_M AADKEMVKGLLHLEDWRRDRPGLGFGGNLFDVATLFVPGAGGAGAGAKGA MUL_2318|M.ulcerans_Agy99 AADKEMVKGLLHLEDWRRDRPGLGFGGNLFDVATLFVPGAGGAGAGAKGA MAV_2415|M.avium_104 QARLQELKGLVHADDWTRDRPGLGAGEVAFDAATLIAPGLGEAGAAADGA Mb3933c|M.bovis_AF2122/97 ESWKQFGKSLIHWDEWTTN-PNEALGKTVFDAATLALPGGPLSKLGSKGR Rv3903c|M.tuberculosis_H37Rv ESWKQFGKSLIHWDEWTTN-PNEALGKTVFDAATLALPGGPLSKLGSKGR MSMEG_1870|M.smegmatis_MC2_155 DIGIAAGKEFFAWDQLTGENPGRGIGEAGFNIAGLFVGGPLSKGGTVAKG TH_3868|M.thermoresistible__bu EILAEMGKTIVAWDKWSGENPGRAAGEAIFNVGSFFT--PVG----VLGG MAB_3131c|M.abscessus_ATCC_199 SFDLTYGEDEGGEEDLRTRPPVVTVMGHVDHGKTRLLDTIRKANVREGEA Mvan_2314|M.vanbaalenii_PYR-1 SFDLTYGEDEGGEEDLEIRPPVVTVMGHVDHGKTRLLDTIRNATVREGEA MLBr_02591|M.leprae_Br4923 QPWVDAAFKKRGID---PENFWRSAGLPEFRFP----------------- Mflv_3843|M.gilvum_PYR-GCK PAPGGPGVPAVGDTAVVTPPAPGAPGTPAVNSVETFSPPAPPAATPPSSG MMAR_3072|M.marinum_M AGAARAAEVGGEAADAAAAVGRGGRLAGEVGDLAGAGRTLGDIGKTGRGL MUL_2318|M.ulcerans_Agy99 AGAARAAEVGGEAADAAAAAGRGGRLAGEVGDLAGAGRTLGDIGKTGRGL MAV_2415|M.avium_104 SAAARGAEA---EADAAGAAGR-------VGGIAGARGALTDIAKSTADL Mb3933c|M.bovis_AF2122/97 D------------------------------ILAGVRGLKERLEPTTPHL Rv3903c|M.tuberculosis_H37Rv D------------------------------ILAGVRGLKERLEPTTPHL MSMEG_1870|M.smegmatis_MC2_155 VNKVRRAFD---HADSPPLDLPGRHGLDGNDLSVTGSRVPEVPEIRQDGI TH_3868|M.thermoresistible__bu TTRATTSLG---RAAS----AFGRG---------VDARTPGIPGT---GI MAB_3131c|M.abscessus_ATCC_199 GGITQHIGAYQVAVEHDGTERPITFIDTPGHEAFTAMRARGAKATDIAIL Mvan_2314|M.vanbaalenii_PYR-1 GGITQHIGAYQVTVDLDGTERPITFIDTPGHEAFTAMRARGAKATDIAIL MLBr_02591|M.leprae_Br4923 -------------------------------DPNGTRFPNGAPPPAPPVL Mflv_3843|M.gilvum_PYR-GCK SVETFSPPAPPAPGTGTNSTVEISTPPPPGTPGLPSEGSTTYTTPPTPEI : MMAR_3072|M.marinum_M TEDLAN--LGGDLPKADPPVGGRPVALPPP-KPAGAPAEPTPRPVESVP- MUL_2318|M.ulcerans_Agy99 TEDLAN--LGGDLPKADPPVGGRPVALPPP-KPAGAPIEPTPRPVESVP- MAV_2415|M.avium_104 PKNLEG--VTKDLPEIKPPTGGAPVGLGPGGKPIEAPVESAPRPPDGTPG Mb3933c|M.bovis_AF2122/97 EPPATPPRPGPQPPRIEPPESGHPAPAPAAKPAPVPANGPLPHSPTESK- Rv3903c|M.tuberculosis_H37Rv EPPATPPRPGPQPPRIEPPESGHPAPAPAAKPAPVPANGPLPHSPTESK- MSMEG_1870|M.smegmatis_MC2_155 PDSVINPAPSNRLDAPSNPGGPEAPVRPPEPPGPTTHNPGGTRPPGGGD- TH_3868|M.thermoresistible__bu PGRGVEPAPS--------PAG-----RPPAQRADAGH--GGERAP----- MAB_3131c|M.abscessus_ATCC_199 VVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRAQLTEY Mvan_2314|M.vanbaalenii_PYR-1 VVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRGQLTEY MLBr_02591|M.leprae_Br4923 EGTPENPGPAVPPGSPCSYTPAHPGGNNTIGDEMGLPRPWNPLPCAGAT- Mflv_3843|M.gilvum_PYR-GCK TLNPANSGIDIATPPAPGLPGAPLEATANITTPGTPGVPGAPVNSSIDVA MMAR_3072|M.marinum_M --------------PG--------------KPALEAP------------- MUL_2318|M.ulcerans_Agy99 --------------PG--------------KPALEAP------------- MAV_2415|M.avium_104 AQRGSPPVATSPASPGPAGDSGAGPHGPSSSPAPAAPPGGPVGPHDPAPA Mb3933c|M.bovis_AF2122/97 ------------------------------PPPVDRP------------- Rv3903c|M.tuberculosis_H37Rv ------------------------------PPPVDRP------------- MSMEG_1870|M.smegmatis_MC2_155 ------------------------------GPPPESP------------- TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 N------------------------------------------------- Mvan_2314|M.vanbaalenii_PYR-1 G------------------------------------------------- MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK TPG-------------EVGVPAAPIERSMTVTTPDTPG------------ MMAR_3072|M.marinum_M -----------------------------SGAPG---SVVPGR------- MUL_2318|M.ulcerans_Agy99 -----------------------------SGAPG---SVVPGR------- MAV_2415|M.avium_104 PAPAASPGGPGGSGGVHDPAPAPAPAPAASGGPGDPASVPSGGPHEPASV Mb3933c|M.bovis_AF2122/97 ---------------------------AEPVAP----------------- Rv3903c|M.tuberculosis_H37Rv ---------------------------AEPVAP----------------- MSMEG_1870|M.smegmatis_MC2_155 ------------------------HRPVGPADPGPT-------------- TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2314|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK ----------------------------APGAPANAAVDVATP------- MMAR_3072|M.marinum_M --------------------SEPAFGPHDPASAPVAGSHPAATAVTPGER MUL_2318|M.ulcerans_Agy99 --------------------SEPAFGPHDPASAPVAGSHPAATAVTPGER MAV_2415|M.avium_104 PAEEPREPVSVPAGGVHDPVAEPTGGPHEPASVPAAGSRLASVQAAAGDG Mb3933c|M.bovis_AF2122/97 --------------------SSASAGQPRVSAATTPGTHVPHGLPQPGEH Rv3903c|M.tuberculosis_H37Rv --------------------SSASAGQPRVSAATTPGTHVPHGLPQPGEH MSMEG_1870|M.smegmatis_MC2_155 -----------------RGDAPPPHTPSTPEPSHPGSSSVGEPGIRGNPE TH_3868|M.thermoresistible__bu --------------------VEPPAHETVLDHIENTAGNLNNLGVR-NRE MAB_3131c|M.abscessus_ATCC_199 ------------------LVAEDFGGDTMFVDISARQGTNIEQLLEAVLL Mvan_2314|M.vanbaalenii_PYR-1 ------------------LVPEEYGGDAMFVDISAKQGTNIEALLEAVIL MLBr_02591|M.leprae_Br4923 --------------------AGPYGGPAFPAPIDVQTSPPNPDGLPLLPG Mflv_3843|M.gilvum_PYR-GCK ------------------PAPGVPGAPVVGEAGVTTPGAPGAPGAPANAA MMAR_3072|M.marinum_M VSPVTPHVG--EPARAPGVPVGAAAG-PVPAGAHSAPA--AIPAAPGAHV MUL_2318|M.ulcerans_Agy99 LSPVTPHVG--EPARAPGVPVGAAAG-PVPAGAHSAPA--AIPAAPGAHV MAV_2415|M.avium_104 LPSATPQLFDHTPSQVP-VPAGGSSGEAASVGAHSPSS--ASSAAP--HF Mb3933c|M.bovis_AF2122/97 VPAQAPPAT----TLLGGPPVESAPATAHQPQWATTPA--APAAAP---H Rv3903c|M.tuberculosis_H37Rv VPAQAPPAT----TLLGGPPVESAPATAHQPQWATTPA--APAAAP---H MSMEG_1870|M.smegmatis_MC2_155 PSHTPPSVDHTPQHAPEPATPAAQNDAPHTSAESNSTP--THQPSTSDAP TH_3868|M.thermoresistible__bu DTEEQPSN------------------------------------------ MAB_3131c|M.abscessus_ATCC_199 TADAALDLRANPDMEAQGVAIEAHLDRGRGPVATVLIQRGTLRVGDSIVA Mvan_2314|M.vanbaalenii_PYR-1 TADASLDLRANPDMEAQGVAIEAHLDRGRGPVATVLIQRGTLRVGDSVVA MLBr_02591|M.leprae_Br4923 IAIAGRPGD--PAPNVPGTPVPLPPNAPPGARTEQLAP-----AAPAQDS Mflv_3843|M.gilvum_PYR-GCK VDVATPPAPGVPGAPVVGEAAVTTPGAPGVPGVPAGGDAGVVTPPAPGVP MMAR_3072|M.marinum_M MTGAGRPAELSAPHGGVPQGLGDAGPSGGHPHGLPPHGGGPHGPGDASHG MUL_2318|M.ulcerans_Agy99 MTGAGRPAELSAPHGGVPHGLGDAGPSGGHPHGLPPHGGGPHGPGDASHG MAV_2415|M.avium_104 ESPGGRPSEVPAPNGGA-HGPGESGPAGGHPPGEPPHGGKPSGDG----G Mb3933c|M.bovis_AF2122/97 STPGGVHSTESGPHGRSLSAHGSEPTHDGASHGSGHGSGSEPPGLHAPHR Rv3903c|M.tuberculosis_H37Rv STPGGVHSTESGPHGRSLSAHGSEPTHDGASHGSGHGSGSEPPGLHAPHR MSMEG_1870|M.smegmatis_MC2_155 ASTHSPTQHIGGSVGGEHSAISSDSNIGSAEHHRPVTDESRNWADEQAHR TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 GDAYGRVRRMVDEHGEDVEEALPSRPVQVIGFTSVPGAGDNLLVVDEDRI Mvan_2314|M.vanbaalenii_PYR-1 GDAYGRVRRMVDEHGEDVEEALPSRPVQVIGFTSVPGAGDNFLVVDEDRI MLBr_02591|M.leprae_Br4923 SAPHEPREQLSAPLINPGGTGGSGGAGGSRN------------------- Mflv_3843|M.gilvum_PYR-GCK GAPVVGEAGVTTPGAPGVPGVPAGGDAGVVTPPAPGVPGAPAATEAGLAT MMAR_3072|M.marinum_M ARHAEPPRDGTAHG---------TADGGDAHGDDVSGHGLSAEKRDEIIA MUL_2318|M.ulcerans_Agy99 ARHAEPPRDGTAHG---------TADGGDAHGDDVSGHGLSAEKRDEIIA MAV_2415|M.avium_104 PPDEDSHRDGTPGN---------GDDGAAGEIDDGP-AGVDGQSTPAKVA Mb3933c|M.bovis_AF2122/97 EQQLAMHSNEPAGE---------GWHRLSDEAVDPQYGEPLSRHWDFTDN Rv3903c|M.tuberculosis_H37Rv EQQLAMHSNEPAGE---------GWHRLSDEAVDPQYGEPLSRHWDFTDN MSMEG_1870|M.smegmatis_MC2_155 PAEQQPAHNAAAEQPVTHDRNSAETNESREPAYSSAVNGPQPAMGPMMSP TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 ARQIADRRSARKRN---------ALAARSRKRISLDDLDAALKETSQLNL Mvan_2314|M.vanbaalenii_PYR-1 ARQIADRRSARKRN---------ALAARTRKRISLEDLDSALKETSQLNL MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PPGPGAPGAPVVGDAG-VATPPGPGVPGAPIVDEAGLATPPAPVAPVEGA MMAR_3072|M.marinum_M MPKGSRPDPSEYLSPEYIQGHLDRFTDGATRFMPESNLDKYG-IAQRD-- MUL_2318|M.ulcerans_Agy99 MRKGSRPDPSEYLSPEYIQGHLDRFTGGATRFMPESNLDKYG-IAQRD-- MAV_2415|M.avium_104 GVDYPLPPSDALRVLEHPGAELQRLADGG---VPSSILEGYEPLAGRSVD Mb3933c|M.bovis_AF2122/97 PADRSRINPVVAQLMEDPNAPFGRDPQGQP-YTQERYQERFNSVGPWG-- Rv3903c|M.tuberculosis_H37Rv PADRSRINPVVAQLMEDPNAPFGRDPQGQP-YTQERYQERFNSVGPWG-- MSMEG_1870|M.smegmatis_MC2_155 GVGSGPGSPMTPHAPGPVHGGGESPSPAAKLPTPDTSTRGPETRPSHTGS TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 ILKGDNAGTVEALEEALLGIAIDDEVQLRVIDRGVGGVTETNVNLASASD Mvan_2314|M.vanbaalenii_PYR-1 ILKGDNSGTVEALEEALLGIQVDDEVELRVIDRGVGGVTETNVNLASASD MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK GGAVPPAGPPPAPVFGDAGAPVEAAAGGAPVEAAAGVTGGGSVAGAGAGG MMAR_3072|M.marinum_M --GTSFVMPKS--------EADAMIAGTGG--------DLRLMEEELGLP MUL_2318|M.ulcerans_Agy99 --GTSFVMPKS--------EADAMIAGTGG--------DLRLMEEELGLP MAV_2415|M.avium_104 DFNREFTIETSNGERGWDWEAQAPENGFAGNPIESNHIPAGLHFDRIGPN Mb3933c|M.bovis_AF2122/97 --QQYSNFPPN--------NGAVPGTRIAYTNLEKFLSDYGPQLDRIGGD Rv3903c|M.tuberculosis_H37Rv --QQYSNFPPN--------NGAVPGTRIAYTNLEKFLSDYGPQLDRIGGD MSMEG_1870|M.smegmatis_MC2_155 PETPRAQQPSAVGPTPGSTPSAPVHSSADQSRQSASTSPASSTSEQTAPK TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 AIIIGFNVRAEG--------KATELANREGVDIRYYSVIYQAIDEIESAL Mvan_2314|M.vanbaalenii_PYR-1 AIIIGFNVRAEG--------KATELANREGVEIRYYSIIYQAIDEIESAL MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK GAGGAAGGAGVEGASGAVGAAGGPGAGAAPAAAGGAAPGGAPGGPVAGGG MMAR_3072|M.marinum_M EG-FLDSNQIVRIDIEDPR----QFNLRIPSGNE---------------- MUL_2318|M.ulcerans_Agy99 EG-FLDSNQIVRIDIEDPR----QFNLRIPSGNE---------------- MAV_2415|M.avium_104 GGGFLSPEGVPLAERATPPGLAAQYHVFEGTGRE---------------- Mb3933c|M.bovis_AF2122/97 QGKYLAIMEHGRPASWEQR----ALHVTSLRDPY---------------- Rv3903c|M.tuberculosis_H37Rv QGKYLAIMEHGRPASWEQR----ALHVTSLRDPY---------------- MSMEG_1870|M.smegmatis_MC2_155 EHGTAPGSSVPPSDSHHNSPPPKPEPPHDSSGLEPPVHDGDAFTDPAKSD TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 KGMLKPVYEEVELGRAEIRAMFRSSKVGNIAGCLVTSG------------ Mvan_2314|M.vanbaalenii_PYR-1 KGMLKPVYEEKELGRAEIRAIFRSSKVGNIAGCLVQSG------------ MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PVGGPGALPAPGAPIVGEAGVVSPPAPGVPGGAAAVPAGAVTPPAPGVPG MMAR_3072|M.marinum_M ------AGANEQWIPG-------------GRLPTGASEAVVDGGK---IP MUL_2318|M.ulcerans_Agy99 ------AGANEQWIPG-------------GLLPTGASEAVVDGGK---VP MAV_2415|M.avium_104 ------IPAGKDWVVQHGPAKE-----AFGQPGGGDQWIVLDRATNRPVP Mb3933c|M.bovis_AF2122/97 ------HAYTIDWLPEGWFIEVSEVAPGCGQPGGSIQVRIFDHQN-EMRK Rv3903c|M.tuberculosis_H37Rv ------HAYTIDWLPEGWFIEVSEVAPGCGQPGGSIQVRIFDHQN-EMRK MSMEG_1870|M.smegmatis_MC2_155 LDYNPMLDENGHYVPGSLPSYDELLRLTRTEPDSAHYWSGRDANGVGVGP TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 ----IIRRNAKARLLRDNIVVAETVTISSLRREKDDVVEVRDGYECGLTL Mvan_2314|M.vanbaalenii_PYR-1 ----IMRRNAKARLLRDNVVVAENLTISSLKREKDDVTEVRDGYECGLTL MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK APVFGEAGVVTPPAPGVPGGAAAVPAGVVTPPAPGVPGGAAAVPAGAVTP MMAR_3072|M.marinum_M QGDYTVTDVFEEK------------------------------------- MUL_2318|M.ulcerans_Agy99 QGDYTVTDVFEEK------------------------------------- MAV_2415|M.avium_104 VDELIRRRLLREITPPNDKLAIGYRGS----------------------- Mb3933c|M.bovis_AF2122/97 VEELIRRGVLRQ-------------------------------------- Rv3903c|M.tuberculosis_H37Rv VEELIRRGVLRQ-------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 DGSGIAERIAEGSNGTTLEMTLERNGVHPLPAWNRHDPESVRFWEDASAA TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 TYNDIKEGDVIEAYELREKERV---------------------------- Mvan_2314|M.vanbaalenii_PYR-1 TYSDIKEGDVIETYELVEKART---------------------------- MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PAPGVPGAPVFGDAGVATPPVPGVPGGGTTVPAASVTPPAPGVPGGASTV MMAR_3072|M.marinum_M -------------------------------------------------- MUL_2318|M.ulcerans_Agy99 -------------------------------------------------- MAV_2415|M.avium_104 -------------------------------------------------- Mb3933c|M.bovis_AF2122/97 -------------------------------------------------- Rv3903c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 YAENARGDVTAIVGSDLRPGNIWQTVEIPRLMDNPNVTRIVQIDPDTGRA TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2314|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PGNAGTPSTPGLPPGSTDTYINYPAPPVPPTPPNSTGVSAGTPGSPAPGT MMAR_3072|M.marinum_M -------------------------------------------------- MUL_2318|M.ulcerans_Agy99 -------------------------------------------------- MAV_2415|M.avium_104 -------------------------------------------------- Mb3933c|M.bovis_AF2122/97 -------------------------------------------------- Rv3903c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 TELFHRTTSADGPAPNGQMEPTARHDGLTSETDSRTLRDTDQDSIDRASN TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2314|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PGSTLTLTDLLTPPGIARTLQNTASSVMGATPPGTPPVPGGSGSVSLAVP MMAR_3072|M.marinum_M -------------------------------------------------- MUL_2318|M.ulcerans_Agy99 -------------------------------------------------- MAV_2415|M.avium_104 -------------------------------------------------- Mb3933c|M.bovis_AF2122/97 -------------------------------------------------- Rv3903c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 KPDADVRAEPSHSWRDDTDQQRGDDRGYSDDDGPRENAVGPDGRYKISGH TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2314|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK GTPSPIAPLAATGLSNLVSPPSLTIPSIPGLPVPLPNTVPVPSDLLCVGT MMAR_3072|M.marinum_M -------------------------------------------------- MUL_2318|M.ulcerans_Agy99 -------------------------------------------------- MAV_2415|M.avium_104 -------------------------------------------------- Mb3933c|M.bovis_AF2122/97 -------------------------------------------------- Rv3903c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 GDYHSGDGTFTVPADTSVTVYGEHGSPITQSLGNLIESGGDTSRVFKKTY TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2314|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK DWSASQGDSAATPPAAEVPRVVTGAAPTGDRRDRWGNR------------ MMAR_3072|M.marinum_M -------------------------------------------------- MUL_2318|M.ulcerans_Agy99 -------------------------------------------------- MAV_2415|M.avium_104 -------------------------------------------------- Mb3933c|M.bovis_AF2122/97 -------------------------------------------------- Rv3903c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 YPGETMPNYTLLPPDDMNIVGTPHTVDRATTLSDLLQPNMGAVDFVACLG TH_3868|M.thermoresistible__bu -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2314|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_02591|M.leprae_Br4923 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_3072|M.marinum_M ------------------------------------- MUL_2318|M.ulcerans_Agy99 ------------------------------------- MAV_2415|M.avium_104 ------------------------------------- Mb3933c|M.bovis_AF2122/97 ------------------------------------- Rv3903c|M.tuberculosis_H37Rv ------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 SWNHRVFDVHGIYHQDTYDFIEKYPWPEPENLGDDDW TH_3868|M.thermoresistible__bu ------------------------------------- MAB_3131c|M.abscessus_ATCC_199 ------------------------------------- Mvan_2314|M.vanbaalenii_PYR-1 ------------------------------------- MLBr_02591|M.leprae_Br4923 ------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------