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VAPLAVDPEAMYAAGSAVAAIGDSLAANLTILTAGVSAHTGVDRAGEVFGLGYQDSAESMLKAAAGVVNA CRKCGALIQQGASNYSAAEAASTLGGGSGALPAPSAPADLAAPGPPGTWGKGEPPPLLWAVIQALVSEVW PDGDEAGLHAAASRWHGFAAAMNGVQGTLNASKALFDSQQIPEGEKIDHALAEIGAAAAAIGQQCDALAR TVDEFADRVGHAQQAIRDLLHRIEALGDIGHDIMLIIDGDAWDEIQKIARDVNAVLQHLGQEARAFEQEI RLLMQAADREIVTCQKYARRGLITFLGEDVGNPVATALDFGINVQEGVVKGAVGMGLGLVDLSPHWIALD PEGAGATWGGLVKNAWKESFVNAAVNPQEFAQARLQELKGLVHADDWTRDRPGLGAGEVAFDAATLIAPG LGEAGAAADGASAAARGAEAEADAAGAAGRVGGIAGARGALTDIAKSTADLPKNLEGVTKDLPEIKPPTG GAPVGLGPGGKPIEAPVESAPRPPDGTPGAQRGSPPVATSPASPGPAGDSGAGPHGPSSSPAPAAPPGGP VGPHDPAPAPAPAASPGGPGGSGGVHDPAPAPAPAPAASGGPGDPASVPSGGPHEPASVPAEEPREPVSV PAGGVHDPVAEPTGGPHEPASVPAAGSRLASVQAAAGDGLPSATPQLFDHTPSQVPVPAGGSSGEAASVG AHSPSSASSAAPHFESPGGRPSEVPAPNGGAHGPGESGPAGGHPPGEPPHGGKPSGDGGPPDEDSHRDGT PGNGDDGAAGEIDDGPAGVDGQSTPAKVAGVDYPLPPSDALRVLEHPGAELQRLADGGVPSSILEGYEPL AGRSVDDFNREFTIETSNGERGWDWEAQAPENGFAGNPIESNHIPAGLHFDRIGPNGGGFLSPEGVPLAE RATPPGLAAQYHVFEGTGREIPAGKDWVVQHGPAKEAFGQPGGGDQWIVLDRATNRPVPVDELIRRRLLR EITPPNDKLAIGYRGS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_2415 | - | - | 100% (996) | hypothetical protein MAV_2415 |
M. avium 104 | MAV_4644 | - | 1e-71 | 33.19% (702) | hypothetical protein MAV_4644 |
M. avium 104 | MAV_4827 | - | 4e-19 | 29.94% (314) | hypothetical protein MAV_4827 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3933c | - | 1e-60 | 30.87% (677) | hypothetical protein Mb3933c |
M. gilvum PYR-GCK | Mflv_3843 | - | 3e-24 | 29.93% (421) | hypothetical protein Mflv_3843 |
M. tuberculosis H37Rv | Rv3903c | - | 1e-60 | 30.87% (677) | hypothetical protein Rv3903c |
M. leprae Br4923 | MLBr_01556 | infB | 2e-10 | 31.91% (188) | translation initiation factor IF-2 |
M. abscessus ATCC 19977 | MAB_3131c | - | 6e-18 | 26.13% (509) | translation initiation factor IF-2 (InfB) |
M. marinum M | MMAR_3072 | - | 1e-164 | 40.97% (903) | hypothetical protein MMAR_3072 |
M. smegmatis MC2 155 | MSMEG_1870 | - | 2e-60 | 26.26% (872) | hypothetical protein MSMEG_1870 |
M. thermoresistible (build 8) | TH_3868 | - | 4e-24 | 25.91% (359) | PUTATIVE putative conserved hypothetical protein |
M. ulcerans Agy99 | MUL_2318 | - | 1e-162 | 41.27% (911) | hypothetical protein MUL_2318 |
M. vanbaalenii PYR-1 | Mvan_2552 | - | 5e-22 | 27.01% (485) | hypothetical protein Mvan_2552 |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_3843|M.gilvum_PYR-GCK ----------MSRTKKSIVVVMMGSAGLFLSAPLLGPAANATPTRGGVPC Mvan_2552|M.vanbaalenii_PYR-1 ----------MSRTKKSIVVVMMGSAGLFLSAPLLGPSANATPTRGGVPC MMAR_3072|M.marinum_M ------------MAPLSVDPEALSGAGSAVAAAGDALAAALSSLTTGFS- MUL_2318|M.ulcerans_Agy99 ------MGKNPGVAPLSVDPEALSGAGSAVAAAGDALAAALSSLTTGFS- MAV_2415|M.avium_104 ------------MAPLAVDPEAMYAAGSAVAAIGDSLAANLTILTAGVS- Mb3933c|M.bovis_AF2122/97 ------------MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAALAG Rv3903c|M.tuberculosis_H37Rv ------------MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAALAG MSMEG_1870|M.smegmatis_MC2_155 MPSNSGGGGGVSGIRIEVDPQVLIRAGESMLSLGNQLDMLMGALGPMLSS TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 ---------MAGKARVHELAKELGVTSKEVLARLNEQGEFVKSASSTVEA MAB_3131c|M.abscessus_ATCC_199 ---------MAGKARVHELAKELGVTSKEVLARLSDQGEFVKSASSTVEA Mflv_3843|M.gilvum_PYR-GCK VGILQQIVTRPGEIPQALTDTARSFTEPPKP------------------- Mvan_2552|M.vanbaalenii_PYR-1 VGILQQVISRPGDIPQALTETARSFTNPGQP------------------- MMAR_3072|M.marinum_M --ANTGQDAAGEVFGLAYQDAAESLVKAAGA------------------- MUL_2318|M.ulcerans_Agy99 --ANTGQDTAGEVFGLAYQDAAESLVKAAGA------------------- MAV_2415|M.avium_104 --AHTGVDRAGEVFGLGYQDSAESMLKAAAG------------------- Mb3933c|M.bovis_AF2122/97 CAGMAGDDPAGAVFGRSYDGSAAALVQAMSV------------------- Rv3903c|M.tuberculosis_H37Rv CAGMAGDDPAGAVFGRSYDGSAAALVQAMSV------------------- MSMEG_1870|M.smegmatis_MC2_155 G-IASGIDLAGLAMALDYGDLTQKFSNTLAN------------------- TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 PVARRLRESFGGIKPAADKGAEQVATKAQAKRLGESLDQTLDRALDKAVA MAB_3131c|M.abscessus_ATCC_199 PVARRLRESFGGGDKPAPAASNGAAAEAAAP-------------PKKAGP Mflv_3843|M.gilvum_PYR-GCK APPVVRPPASSSSSAGTPPVPGRPPASVVTPSSGATPPVPPSPGTPASTS Mvan_2552|M.vanbaalenii_PYR-1 APPVVRPPASSSSSVGTPPVPPTPPGSVVRPSSGATPPVPPTPGTPASTT MMAR_3072|M.marinum_M GINALRHNGAKIQLSASNYSAAEAASTLGGGAGVLPAP-SEPAQFTAPGA MUL_2318|M.ulcerans_Agy99 GINALRHNGAKIQLSASNYSAAEAASTLGGGAGVLPAP-SEPAQFTAPGA MAV_2415|M.avium_104 VVNACRKCGALIQQGASNYSAAEAASTLGGGSGALPAP-SAPADLAAPGP Mb3933c|M.bovis_AF2122/97 ARNGLCNLGDGVRMSAHNYSLAEAMSDVAGRAAPLPAP-PPSGCVGVGAP Rv3903c|M.tuberculosis_H37Rv ARNGLCNLGDGVRMSAHNYSLAEAMSDVAGRAAPLPAP-PPSGCVGVGAP MSMEG_1870|M.smegmatis_MC2_155 GANTFKTVGLRLQASGHNYANADAVSTIGGGAPTGGVKGKFDETKPVDAR TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 GNGATTAAPVQVDHSAAVVPIVAGEGPSTAHREELAPPAGQPSEQPGVPL MAB_3131c|M.abscessus_ATCC_199 KPGAPKPAPKKVAEPVVEAPVAP-EPPAAPAAPAAPAPKPSPAARPAAAE Mflv_3843|M.gilvum_PYR-GCK TRGGTPPVPPAPPAPAGTPASG--ATPPAPPVPGVPAVTSTGGGTPPVPP Mvan_2552|M.vanbaalenii_PYR-1 TGVGTPPVPPTPPGSTVRPAAG--ATPPAPPVPGVPAGTPIGGGTPPLPP MMAR_3072|M.marinum_M PGTLGSGVLAPALWSVVEAFVG-DLWPNGDVAGLHAAAGHWRDFAAALNG MUL_2318|M.ulcerans_Agy99 PGTLGSGVLAPALWSVVEAFVG-DLWPNGDVAGLHAAAGHWRDFAAALNG MAV_2415|M.avium_104 PGTWGKGEPPPLLWAVIQALVS-EVWPDGDEAGLHAAASRWHGFAAAMNG Mb3933c|M.bovis_AF2122/97 PSAVGGGGGAPKGWGWVAPYIG-MIWPNGDSTKLRAAAVAWRSAGTQFAL Rv3903c|M.tuberculosis_H37Rv PSAVGGGGGAPKGWGWVAPYIG-MIWPNGDSTKLRAAAVAWRSAGTQFAL MSMEG_1870|M.smegmatis_MC2_155 DSPSLSVVPPPPAWYLVGSFLGPTAWPSGNPAMLRLTAAQWENLATGFSA TH_3868|M.thermoresistible__bu --------------------------------MLRLTVAQWRNFAHGFAV MLBr_01556|M.leprae_Br4923 PGQQGTPAAPHPGHPGMPTGPHPGPAPKPGGRPPRVGNNPFSSAQSVARP MAB_3131c|M.abscessus_ATCC_199 AAAPAPAPAPAP-RPGATPGPKPG-AP----RVPRVGNNPFSSAQPAERP . Mflv_3843|M.gilvum_PYR-GCK VPGAPVGAPVANPGLPTPPVPGAPVFGDGGAVLPPLPPAPA-GPAGGPAG Mvan_2552|M.vanbaalenii_PYR-1 VPGAPAGTPVANVAPPSPPVPGVPVIGDGGAALPPLPPVPG-GPAAVPAG MMAR_3072|M.marinum_M VQGALNS-PKSVVA--GQDIPEGAQIQQVLSAIGSDLAGVG-AQCQKLAG MUL_2318|M.ulcerans_Agy99 VQGALNS-PKSVVA--GQDIPEGVQIQQVLSAIGSDLAGVG-AQCRKLAG MAV_2415|M.avium_104 VQGTLNA-SKALFD--SQQIPEGEKIDHALAEIGAAAAAIG-QQCDALAR Mb3933c|M.bovis_AF2122/97 TEIQSTAGPMGVIR--AQQLPEAGLIESAFADAYASTTAVV-GQCHQLAA Rv3903c|M.tuberculosis_H37Rv TEIQSTAGPMGVIR--AQQLPEAGLIESAFADAYASTTAVV-GQCHQLAA MSMEG_1870|M.smegmatis_MC2_155 VSNQVSG-SSTAVS--TQKIPEASQIAQAHADLADGVADLA-NQATNLAE TH_3868|M.thermoresistible__bu FEPQLAP-VLAVVS--AQNTPETPAIVSGLDELARGISALT-DASVEVAR MLBr_01556|M.leprae_Br4923 IPRPPAPRP------SASPSSMSPRPGGAVGGGGPRPPRTG-VPRPGGGR MAB_3131c|M.abscessus_ATCC_199 APRPQAPRPGAPRPGGASPSNMPPRP--SPGSMGPRPPRPGGGPRPGGGP . . Mflv_3843|M.gilvum_PYR-GCK LVAPPAPPVPGGPAAVPAGVALPPAPPGAPGAPVFGEAGAAPSGAAAPVA Mvan_2552|M.vanbaalenii_PYR-1 VVTPPAPPIPGGPAAMPAGVAAPPAP-APPGAPIFGEAGAVPPPGVGGAP MMAR_3072|M.marinum_M ALDDFADEVADTQDAIRDLLDRFGSVSGLWNQVMAIFEGDA--------- MUL_2318|M.ulcerans_Agy99 ALDDFADEVADTQDAIRDLLDRFGSVSGLWNQVVAIFEGDA--------- MAV_2415|M.avium_104 TVDEFADRVGHAQQAIRDLLHRIEALGDIGHDIMLIIDGDA--------- Mb3933c|M.bovis_AF2122/97 QLDAYAARIDAVHAAVLDLLARICDPLTGIKEVWEFLTDQD--------- Rv3903c|M.tuberculosis_H37Rv QLDAYAARIDAVHAAVLDLLARICDPLTGIKEVWEFLTDQD--------- MSMEG_1870|M.smegmatis_MC2_155 TLNTFADNVQETQDAIRRLLDRVASIDGIINTVKGIFTGDA--------- TH_3868|M.thermoresistible__bu EVEDFAATVQGTQDAIRRLVGRVS-ISGLFHTVKGILTGDG--------- MLBr_01556|M.leprae_Br4923 PGAPVGGRSDAGGGNYRGGGVG-ALPGGGS----GGFRGRP--------- MAB_3131c|M.abscessus_ATCC_199 RPGGAGRPGGGGGGNYRGGGTGTGAPAGGPPGAGGGFRGRP--------- . . Mflv_3843|M.gilvum_PYR-GCK PAAGSGGAGGAGGGSGIGGPGGGGAPVEGTGGAVPAGAPLAAAGGEVPPP Mvan_2552|M.vanbaalenii_PYR-1 LDGASGVAAPGGPGGGAGAPGAPVAAAAGNAGPPAPGAPVGDQAGVVAPP MMAR_3072|M.marinum_M LDEIKEIAEDIQAVLSNLGRQARAQQQLMQQGMQAIDGLVVGMQRYVRGQ MUL_2318|M.ulcerans_Agy99 LDEIKEIAEDIRAVLSNLGRQARAQQQLMQQGMQAIDGLVVGMQRYVRGQ MAV_2415|M.avium_104 WDEIQKIARDVNAVLQHLGQEARAFEQEIRLLMQAADREIVTCQKYARRG Mb3933c|M.bovis_AF2122/97 EDEIQRIAHDIAVVVDQFSGEVDALAAEITAVVSHAEAVITAMADHAGKQ Rv3903c|M.tuberculosis_H37Rv EDEIQRIAHDIAVVVDQFSGEVDALAAEITAVVSHAEAVITAMADHAGKQ MSMEG_1870|M.smegmatis_MC2_155 LDIIKEVVEDIRTLLGNFQRQVKAVGALLEELKNALNDTVTKFQKWADKN TH_3868|M.thermoresistible__bu KDILREVARDVRTVLDNFQRQVKGVIGLLEELATLIGDAATAFQKWLRPN MLBr_01556|M.leprae_Br4923 ----GGGGHGGGGRPGQRGGAAGAFGRPGGAPRRGRKSKRQKRQEYDSMQ MAB_3131c|M.abscessus_ATCC_199 ----GGG--GGGGRPGQRGGAAGAFGRPGGAPKRGRKSKRAKRAEYENMQ Mflv_3843|M.gilvum_PYR-GCK APPIPGAPVIGEAGVVPPPA-----PPAPAPPAGGLGGAVPPPVPGAPGV Mvan_2552|M.vanbaalenii_PYR-1 APPAPGAPVGDQAGLVAPPG-----PPAPGVPVVDQAGVVAPPGPPAPGV MMAR_3072|M.marinum_M LTQFLGQDVGNPLATVFDTY-----TNTQEGVFKAAVGMVEGIEQLNPQR MUL_2318|M.ulcerans_Agy99 LTQLLGQDVGNPVATVFDTY-----TNTQEGVFKAAVGMVEGIEQLNPQR MAV_2415|M.avium_104 LITFLGEDVGNPVATALDFG-----INVQEGVVKGAVGMGLGLVDLSPHW Mb3933c|M.bovis_AF2122/97 WDRFLHS---NPVGVVIDGT-----GQQLKGFGEEAFGMAKDSWDLGPLR Rv3903c|M.tuberculosis_H37Rv WDRFLHS---NPVGVVIDGT-----GQQLKGFGEEAFGMAKDSWDLGPLR MSMEG_1870|M.smegmatis_MC2_155 LREILGDQVGGAISDIIKFQ-----TDLSTGVLNGVINTVAGTVAFAD-- TH_3868|M.thermoresistible__bu LVAVFGEQVGGAMADRIELR-----TDLGVGVVTGLIGTVTGVVALAD-- MLBr_01556|M.leprae_Br4923 APVVGGVRLPHGNGETIRLARGASLSDFAEKIDANPAALVQALFNLGEMV MAB_3131c|M.abscessus_ATCC_199 APVVGGVRLPHGNGEVIRLARGASLSDFAEKIDANPASLVQALFNLGEMV . Mflv_3843|M.gilvum_PYR-GCK PVVDEAGVVTPPAPGGPGVPTGGEGGVVTPPAPGAPGVPVVDEAGVVTPP Mvan_2552|M.vanbaalenii_PYR-1 PVVDEAGVVTPPGPGAPGVPVVGEAGVVTPPGPGAPGVPVVDEAGVVTPP MMAR_3072|M.marinum_M FLIDPQGAAETWKAMTK----TGLINHLLNPEEAVAADKEMVKG------ MUL_2318|M.ulcerans_Agy99 FLIDPQGAAETWKAMTK----TGLINHLLNPEEAVAADKEMVKG------ MAV_2415|M.avium_104 IALDPEGAGATWGGLVKNAWKESFVNAAVNPQEFAQARLQELKG------ Mb3933c|M.bovis_AF2122/97 ASIDPFGWYRSWEEMLTGMAPLAGLGGENAPG-VVESWKQFGKS------ Rv3903c|M.tuberculosis_H37Rv ASIDPFGWYRSWEEMLTGMAPLAGLGGENAPG-VVESWKQFGKS------ MSMEG_1870|M.smegmatis_MC2_155 --------FDTWKGLGE-----TALAVIKDPSLIDDIGIAAGKE------ TH_3868|M.thermoresistible__bu --------ADTWRGLAN-----LALTVGPDPTKMPEILAEMGKT------ MLBr_01556|M.leprae_Br4923 TATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLEPFDLTYGED----- MAB_3131c|M.abscessus_ATCC_199 TATQSVGDETLELLGGEMNYVVQVVSPEDEDRELLESFDLTYGED----- Mflv_3843|M.gilvum_PYR-GCK APGGPGVPTGGEGGVVTPPAPGAPGAPVVDEAGVVTPPAPGGPGVPAVGD Mvan_2552|M.vanbaalenii_PYR-1 GPGAPGVPVVDEAGVVTPPGPGAPGVPVVDEAGVVTPPAPGAPGVPVDGG MMAR_3072|M.marinum_M ---------LLHLEDWRRDRPGLGFGGNLFDVATLFVPGAGGAGAGAKGA MUL_2318|M.ulcerans_Agy99 ---------LLHLEDWRRDRPGLGFGGNLFDVATLFVPGAGGAGAGAKGA MAV_2415|M.avium_104 ---------LVHADDWTRDRPGLGAGEVAFDAATLIAPGLGEAGAAADGA Mb3933c|M.bovis_AF2122/97 ---------LIHWDEWTTN-PNEALGKTVFDAATLALPGGPLSKLGSKGR Rv3903c|M.tuberculosis_H37Rv ---------LIHWDEWTTN-PNEALGKTVFDAATLALPGGPLSKLGSKGR MSMEG_1870|M.smegmatis_MC2_155 ---------FFAWDQLTGENPGRGIGEAGFNIAGLFVGGPLSKGGTVAKG TH_3868|M.thermoresistible__bu ---------IVAWDKWSGENPGRAAGEAIFNVGSFFT--PVG----VLGG MLBr_01556|M.leprae_Br4923 ---------QGDEDELQVRPPVVTVMGHVDHGKTRLLDTIRKANVREAEA MAB_3131c|M.abscessus_ATCC_199 ---------EGGEEDLRTRPPVVTVMGHVDHGKTRLLDTIRKANVREGEA * . Mflv_3843|M.gilvum_PYR-GCK TAVVTPPAP----GAPGTPAVNSVETFSPPAPPAATPPSSGSVETFSPPA Mvan_2552|M.vanbaalenii_PYR-1 AELVTPPGP----GAPGTPTVSSVETFSPPAPPAPGTPSSGSIETFSPPA MMAR_3072|M.marinum_M AGAARAAEVGGEAADAAAAVGRGGRLAGEVGDLAGAGRTLGDIGKTGRGL MUL_2318|M.ulcerans_Agy99 AGAARAAEVGGEAADAAAAAGRGGRLAGEVGDLAGAGRTLGDIGKTGRGL MAV_2415|M.avium_104 SAAARGAEA---EADAAGAAGR-------VGGIAGARGALTDIAKSTADL Mb3933c|M.bovis_AF2122/97 D------------------------------ILAGVRGLKERLEPTTPHL Rv3903c|M.tuberculosis_H37Rv D------------------------------ILAGVRGLKERLEPTTPHL MSMEG_1870|M.smegmatis_MC2_155 VNKVRRAFD---HADSPPLDLPGRHGLDGNDLSVTGSRVPEVPEIRQDGI TH_3868|M.thermoresistible__bu TTRATTSLG---RAAS----AFGRG---------VDARTPGIPGT---GI MLBr_01556|M.leprae_Br4923 GGITQHIGAYQVGVDLDGSERLITFIDTPGHEAFTAMRARGAKATDIAIL MAB_3131c|M.abscessus_ATCC_199 GGITQHIGAYQVAVEHDGTERPITFIDTPGHEAFTAMRARGAKATDIAIL Mflv_3843|M.gilvum_PYR-GCK PPAPGTGTNSTVEISTPPPPGTPGLPSEGSTTYTTPPTPEITLNPANSG- Mvan_2552|M.vanbaalenii_PYR-1 PPTPGTPANSSVEIVTPPPPGVPGVPGEGSTTYTTPPTPEITLNPANSS- MMAR_3072|M.marinum_M TEDLAN--LGGDLPKADPPVGGRPVALPPP-KPAGAPAEPTPRPVESVP- MUL_2318|M.ulcerans_Agy99 TEDLAN--LGGDLPKADPPVGGRPVALPPP-KPAGAPIEPTPRPVESVP- MAV_2415|M.avium_104 PKNLEG--VTKDLPEIKPPTGGAPVGLGPGGKPIEAPVESAPRPPDGTPG Mb3933c|M.bovis_AF2122/97 EPPATPPRPGPQPPRIEPPESGHPAPAPAAKPAPVPANGPLPHSPTESK- Rv3903c|M.tuberculosis_H37Rv EPPATPPRPGPQPPRIEPPESGHPAPAPAAKPAPVPANGPLPHSPTESK- MSMEG_1870|M.smegmatis_MC2_155 PDSVINPAPSNRLDAPSNPGGPEAPVRPPEPPGPTTHNPGGTRPPGGGD- TH_3868|M.thermoresistible__bu PGRGVEPAPS--------PAG-----RPPAQRADAGH--GGERAP----- MLBr_01556|M.leprae_Br4923 VVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRGQLTEY MAB_3131c|M.abscessus_ATCC_199 VVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRAQLTEY . . Mflv_3843|M.gilvum_PYR-GCK -------------------------IDIATPPAPGLPG------------ Mvan_2552|M.vanbaalenii_PYR-1 -------------------------IDVATPPGPGVPG------------ MMAR_3072|M.marinum_M --------------PG--------------KPALEAP------------- MUL_2318|M.ulcerans_Agy99 --------------PG--------------KPALEAP------------- MAV_2415|M.avium_104 AQRGSPPVATSPASPGPAGDSGAGPHGPSSSPAPAAPPGGPVGPHDPAPA Mb3933c|M.bovis_AF2122/97 ------------------------------PPPVDRP------------- Rv3903c|M.tuberculosis_H37Rv ------------------------------PPPVDRP------------- MSMEG_1870|M.smegmatis_MC2_155 ------------------------------GPPPESP------------- TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 G------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 N------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK ------------------APLEATANITTPGTPG---------------- Mvan_2552|M.vanbaalenii_PYR-1 ------------------VPVEASANVSTPPVPG---------------- MMAR_3072|M.marinum_M -----------------------------SGAPG---SVVPGR------- MUL_2318|M.ulcerans_Agy99 -----------------------------SGAPG---SVVPGR------- MAV_2415|M.avium_104 PAPAASPGGPGGSGGVHDPAPAPAPAPAASGGPGDPASVPSGGPHEPASV Mb3933c|M.bovis_AF2122/97 ---------------------------AEPVAP----------------- Rv3903c|M.tuberculosis_H37Rv ---------------------------AEPVAP----------------- MSMEG_1870|M.smegmatis_MC2_155 ------------------------HRPVGPADPGPT-------------- TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------VPGAPVNSSIDVATPGEVGVPAAPIERSMTV Mvan_2552|M.vanbaalenii_PYR-1 -------------------VPGAPVNSSVEVATPAEVGVPGTPIERSTTL MMAR_3072|M.marinum_M --------------------SEPAFGPHDPASAPVAGSHPAATAVTPGER MUL_2318|M.ulcerans_Agy99 --------------------SEPAFGPHDPASAPVAGSHPAATAVTPGER MAV_2415|M.avium_104 PAEEPREPVSVPAGGVHDPVAEPTGGPHEPASVPAAGSRLASVQAAAGDG Mb3933c|M.bovis_AF2122/97 --------------------SSASAGQPRVSAATTPGTHVPHGLPQPGEH Rv3903c|M.tuberculosis_H37Rv --------------------SSASAGQPRVSAATTPGTHVPHGLPQPGEH MSMEG_1870|M.smegmatis_MC2_155 -----------------RGDAPPPHTPSTPEPSHPGSSSVGEPGIRGNPE TH_3868|M.thermoresistible__bu --------------------VEPPAHETVLDHIENTAGNLNNLGVR-NRE MLBr_01556|M.leprae_Br4923 ------------------LVAEDFGGDTMFIDISAKVGTNIEALLEAVLL MAB_3131c|M.abscessus_ATCC_199 ------------------LVAEDFGGDTMFVDISARQGTNIEQLLEAVLL Mflv_3843|M.gilvum_PYR-GCK TTPDTPGAPGAPANAAVDVATPPAPGVPGAPVVGEAGV--TTPGAPG-AP Mvan_2552|M.vanbaalenii_PYR-1 TTPPTPGVPGTPVNSSVEVATPPAPGAPGVPVVDEAGV--VTPPGPG-AP MMAR_3072|M.marinum_M VSPVTPHVG--EPARAPGVPVGAAAG-PVPAGAHSAPA--AIPAAPGAHV MUL_2318|M.ulcerans_Agy99 LSPVTPHVG--EPARAPGVPVGAAAG-PVPAGAHSAPA--AIPAAPGAHV MAV_2415|M.avium_104 LPSATPQLFDHTPSQVP-VPAGGSSGEAASVGAHSPSS--ASSAAP--HF Mb3933c|M.bovis_AF2122/97 VPAQAPPAT----TLLGGPPVESAPATAHQPQWATTPA--APAAAP---H Rv3903c|M.tuberculosis_H37Rv VPAQAPPAT----TLLGGPPVESAPATAHQPQWATTPA--APAAAP---H MSMEG_1870|M.smegmatis_MC2_155 PSHTPPSVDHTPQHAPEPATPAAQNDAPHTSAESNSTP--THQPSTSDAP TH_3868|M.thermoresistible__bu DTEEQPSN------------------------------------------ MLBr_01556|M.leprae_Br4923 TADAALDLRANSGMEAQGVAIEAHLDRGRGPVATVLVQRGTLRIGDSVVA MAB_3131c|M.abscessus_ATCC_199 TADAALDLRANPDMEAQGVAIEAHLDRGRGPVATVLIQRGTLRVGDSIVA . Mflv_3843|M.gilvum_PYR-GCK GAPANAAVDVATPPAPGVPGAPVVGEAAVTTPGAPGVPGVPAGGDAGVVT Mvan_2552|M.vanbaalenii_PYR-1 GVPVVGEAGVVTPPGPGAPGVPVVDEAGVVTPPGPGAPGVPVVGEAGVVT MMAR_3072|M.marinum_M MTGAGRPAELSAPHGGVPQGLGDAGPSGGHPHGLPPHGGGPHGPGDASHG MUL_2318|M.ulcerans_Agy99 MTGAGRPAELSAPHGGVPHGLGDAGPSGGHPHGLPPHGGGPHGPGDASHG MAV_2415|M.avium_104 ESPGGRPSEVPAPNGGA-HGPGESGPAGGHPPGEPPHGGKPSGDG----G Mb3933c|M.bovis_AF2122/97 STPGGVHSTESGPHGRSLSAHGSEPTHDGASHGSGHGSGSEPPGLHAPHR Rv3903c|M.tuberculosis_H37Rv STPGGVHSTESGPHGRSLSAHGSEPTHDGASHGSGHGSGSEPPGLHAPHR MSMEG_1870|M.smegmatis_MC2_155 ASTHSPTQHIGGSVGGEHSAISSDSNIGSAEHHRPVTDESRNWADEQAHR TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 GDAYGRVRRMVDEHGVDIEAALPSSPVQVIGFTSVPGAGDNFLVVDEDRI MAB_3131c|M.abscessus_ATCC_199 GDAYGRVRRMVDEHGEDVEEALPSRPVQVIGFTSVPGAGDNLLVVDEDRI Mflv_3843|M.gilvum_PYR-GCK PPAPGVPGAPVVGEAGVTTPGAPGVPGVPAGGDAGVVTPPAPGVPGAPAA Mvan_2552|M.vanbaalenii_PYR-1 PPGPGAPGVPVVDEAGVVTPPGPGAPGVPVVGEAGVVTPPGPGAPGVPVV MMAR_3072|M.marinum_M ARHAEPPRDGTAHG---------TADGGDAHGDDVSGHGLSAEKRDEIIA MUL_2318|M.ulcerans_Agy99 ARHAEPPRDGTAHG---------TADGGDAHGDDVSGHGLSAEKRDEIIA MAV_2415|M.avium_104 PPDEDSHRDGTPGN---------GDDGAAGEIDDGP-AGVDGQSTPAKVA Mb3933c|M.bovis_AF2122/97 EQQLAMHSNEPAGE---------GWHRLSDEAVDPQYGEPLSRHWDFTDN Rv3903c|M.tuberculosis_H37Rv EQQLAMHSNEPAGE---------GWHRLSDEAVDPQYGEPLSRHWDFTDN MSMEG_1870|M.smegmatis_MC2_155 PAEQQPAHNAAAEQPVTHDRNSAETNESREPAYSSAVNGPQPAMGPMMSP TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 ARQIADRRSARKRN---------ALAARSRKRISLEDLDSALKETSQLNL MAB_3131c|M.abscessus_ATCC_199 ARQIADRRSARKRN---------ALAARSRKRISLDDLDAALKETSQLNL Mflv_3843|M.gilvum_PYR-GCK TEAGLATPPGPGAPGAPVVGDAGVATPPGPGVPGAPIVDEAGLATPPAP- Mvan_2552|M.vanbaalenii_PYR-1 DEAGVVTPPGPGAPGVPVVDEAGVVTPPGPGAPGVPVVDEAGVVTPPAPP MMAR_3072|M.marinum_M MPKGSRPDPSEYLSPEYIQGHLDRFTDGATRFMPESNLDKYG-IAQRD-- MUL_2318|M.ulcerans_Agy99 MRKGSRPDPSEYLSPEYIQGHLDRFTGGATRFMPESNLDKYG-IAQRD-- MAV_2415|M.avium_104 GVDYPLPPSDALRVLEHPGAELQRLADGG---VPSSILEGYEPLAGRSVD Mb3933c|M.bovis_AF2122/97 PADRSRINPVVAQLMEDPNAPFGRDPQGQP-YTQERYQERFNSVGPWG-- Rv3903c|M.tuberculosis_H37Rv PADRSRINPVVAQLMEDPNAPFGRDPQGQP-YTQERYQERFNSVGPWG-- MSMEG_1870|M.smegmatis_MC2_155 GVGSGPGSPMTPHAPGPVHGGGESPSPAAKLPTPDTSTRGPETRPSHTGS TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 ILKGDNAGTVEALEEALMGIQVDDEVALRVIDRGVGGITETNVNLASASD MAB_3131c|M.abscessus_ATCC_199 ILKGDNAGTVEALEEALLGIAIDDEVQLRVIDRGVGGVTETNVNLASASD Mflv_3843|M.gilvum_PYR-GCK ----VAPVEGAGGAVPPAGPPPAPVFGDAGAPVEAAAGGAPVEAAAGVTG Mvan_2552|M.vanbaalenii_PYR-1 AAAPGAPIDAAAASVAPSGPPAAPVLGEAGVVAPPAP-----------PG MMAR_3072|M.marinum_M --GTSFVMPKS--------EADAMIAGTGG-------------------- MUL_2318|M.ulcerans_Agy99 --GTSFVMPKS--------EADAMIAGTGG-------------------- MAV_2415|M.avium_104 DFNREFTIETSNGERGWDWEAQAPENGFAGNPIESNH------------- Mb3933c|M.bovis_AF2122/97 --QQYSNFPPN--------NGAVPGTRIAYTNLEKFL------------- Rv3903c|M.tuberculosis_H37Rv --QQYSNFPPN--------NGAVPGTRIAYTNLEKFL------------- MSMEG_1870|M.smegmatis_MC2_155 PETPRAQQPSAVGPTPGSTPSAPVHSSADQSRQSAST------------- TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 AIIIGFNVRAEG--------KATELASREGVEIRYYL------------- MAB_3131c|M.abscessus_ATCC_199 AIIIGFNVRAEG--------KATELANREGVDIRYYS------------- Mflv_3843|M.gilvum_PYR-GCK GGSVAGAGAGGGAGGAAGGAGVEGASGAVGAAGGPGAGAAPAAAGGAAPG Mvan_2552|M.vanbaalenii_PYR-1 GGAPGGGAPGAGVG---TGAPIEGAAGAGGVPAAPLAANAGAAT---PPA MMAR_3072|M.marinum_M -----------DLRLMEEELGLPEG-FLDSNQIVRIDIEDPR----QFNL MUL_2318|M.ulcerans_Agy99 -----------DLRLMEEELGLPEG-FLDSNQIVRIDIEDPR----QFNL MAV_2415|M.avium_104 ----------IPAGLHFDRIGPNGGGFLSPEGVPLAERATPPGLAAQYHV Mb3933c|M.bovis_AF2122/97 ----------SDYGPQLDRIGGDQGKYLAIMEHGRPASWEQR----ALHV Rv3903c|M.tuberculosis_H37Rv ----------SDYGPQLDRIGGDQGKYLAIMEHGRPASWEQR----ALHV MSMEG_1870|M.smegmatis_MC2_155 ----------SPASSTSEQTAPKEHGTAPGSSVPPSDSHHNSPPPKPEPP TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 ----------VIYQAIDDIEKALRGMLKPIYEENQLGRAEIRALFRSSKV MAB_3131c|M.abscessus_ATCC_199 ----------VIYQAIDEIESALKGMLKPVYEEVELGRAEIRAMFRSSKV Mflv_3843|M.gilvum_PYR-GCK GAPGGPVAGGGPVGGPGALPAPGAPIVGEAGVVSPPAPGVPGGAAAVPAG Mvan_2552|M.vanbaalenii_PYR-1 AATGG----------------AGAPIDAAAGAAAPPAP------------ MMAR_3072|M.marinum_M RIPSGNE----------------------AGANEQWIPG----------- MUL_2318|M.ulcerans_Agy99 RIPSGNE----------------------AGANEQWIPG----------- MAV_2415|M.avium_104 FEGTGRE----------------------IPAGKDWVVQHGPAKE----- Mb3933c|M.bovis_AF2122/97 TSLRDPY----------------------HAYTIDWLPEGWFIEVSEVAP Rv3903c|M.tuberculosis_H37Rv TSLRDPY----------------------HAYTIDWLPEGWFIEVSEVAP MSMEG_1870|M.smegmatis_MC2_155 HDSSGLEPPVHDGDAFTDPAKSDLDYNPMLDENGHYVPGSLPSYDELLRL TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 GIIAGCIISSG---------------VVRRNAKVRLLRDNIVVTDNLTVT MAB_3131c|M.abscessus_ATCC_199 GNIAGCLVTSG---------------IIRRNAKARLLRDNIVVAETVTIS Mflv_3843|M.gilvum_PYR-GCK AVTPPAPGVPGAPVFGEAGVVTPPAPGVPGGAAAVPAGVVTPPAPGVPGG Mvan_2552|M.vanbaalenii_PYR-1 ----PAP---GAPIFGEAGVAAPPLPPAPGGAGAVPAGVVTPPVPGVPGG MMAR_3072|M.marinum_M --GRLPTGASEAVVDGGK---IPQGDYTVTDVFEEK-------------- MUL_2318|M.ulcerans_Agy99 --GLLPTGASEAVVDGGK---VPQGDYTVTDVFEEK-------------- MAV_2415|M.avium_104 AFGQPGGGDQWIVLDRATNRPVPVDELIRRRLLREITPPNDKLAIGYRGS Mb3933c|M.bovis_AF2122/97 GCGQPGGSIQVRIFDHQN-EMRKVEELIRRGVLRQ--------------- Rv3903c|M.tuberculosis_H37Rv GCGQPGGSIQVRIFDHQN-EMRKVEELIRRGVLRQ--------------- MSMEG_1870|M.smegmatis_MC2_155 TRTEPDSAHYWSGRDANGVGVGPDGSGIAERIAEGSNGTTLEMTLERNGV TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 SLRREKDDVTEVREGFECGMTLGYSDIKEGDVIESYELVEKQRA------ MAB_3131c|M.abscessus_ATCC_199 SLRREKDDVVEVRDGYECGLTLTYNDIKEGDVIEAYELREKERV------ Mflv_3843|M.gilvum_PYR-GCK AAAVPAGAVTPPAPGVPGAPVFGDAGVATPPVPGVPGGGTTVPAASVTPP Mvan_2552|M.vanbaalenii_PYR-1 AGAVPAGAVTPPTP----------------PVPGSSSGG----------- MMAR_3072|M.marinum_M -------------------------------------------------- MUL_2318|M.ulcerans_Agy99 -------------------------------------------------- MAV_2415|M.avium_104 -------------------------------------------------- Mb3933c|M.bovis_AF2122/97 -------------------------------------------------- Rv3903c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 HPLPAWNRHDPESVRFWEDASAAYAENARGDVTAIVGSDLRPGNIWQTVE TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK APGVPGGASTVPGNAGTPSTPGLPPGSTDTYINYPAPPVPPTPPNSTGVS Mvan_2552|M.vanbaalenii_PYR-1 ------------------------------FVNYPAPPVPPTPPNSAGVN MMAR_3072|M.marinum_M -------------------------------------------------- MUL_2318|M.ulcerans_Agy99 -------------------------------------------------- MAV_2415|M.avium_104 -------------------------------------------------- Mb3933c|M.bovis_AF2122/97 -------------------------------------------------- Rv3903c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 IPRLMDNPNVTRIVQIDPDTGRATELFHRTTSADGPAPNGQMEPTARHDG TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK AGTPGSPAPGTPGSTLTLTDLLTPPGIARTLQNTASSVMGATPPGTPPVP Mvan_2552|M.vanbaalenii_PYR-1 TGTPGSPIPGTPGSTLTISDLLTPPGVARTVQNTASSVMSIAPPGTPPVP MMAR_3072|M.marinum_M -------------------------------------------------- MUL_2318|M.ulcerans_Agy99 -------------------------------------------------- MAV_2415|M.avium_104 -------------------------------------------------- Mb3933c|M.bovis_AF2122/97 -------------------------------------------------- Rv3903c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 LTSETDSRTLRDTDQDSIDRASNKPDADVRAEPSHSWRDDTDQQRGDDRG TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK GGSGSVSLAVPGTPSPIAPLAATGLSNLVSPPSLTIPSIPGLPVPLPNTV Mvan_2552|M.vanbaalenii_PYR-1 GGAGSVSVGVPAPPSPLTPLAATGLSNLVSPPSLTIPSIPGLPVPLPNEV MMAR_3072|M.marinum_M -------------------------------------------------- MUL_2318|M.ulcerans_Agy99 -------------------------------------------------- MAV_2415|M.avium_104 -------------------------------------------------- Mb3933c|M.bovis_AF2122/97 -------------------------------------------------- Rv3903c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 YSDDDGPRENAVGPDGRYKISGHGDYHSGDGTFTVPADTSVTVYGEHGSP TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PVPSDLLCVGTDWSASQGDSAATPPAAEVPR-VVTGAAPTGDRRDRWGNR Mvan_2552|M.vanbaalenii_PYR-1 PVPSDLLCVGTDWSATQGDSATTPVNAEIPRALVTGAAPVGDRRDRWDTR MMAR_3072|M.marinum_M -------------------------------------------------- MUL_2318|M.ulcerans_Agy99 -------------------------------------------------- MAV_2415|M.avium_104 -------------------------------------------------- Mb3933c|M.bovis_AF2122/97 -------------------------------------------------- Rv3903c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 ITQSLGNLIESGGDTSRVFKKTYYPGETMPNYTLLPPDDMNIVGTPHTVD TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_3072|M.marinum_M -------------------------------------------------- MUL_2318|M.ulcerans_Agy99 -------------------------------------------------- MAV_2415|M.avium_104 -------------------------------------------------- Mb3933c|M.bovis_AF2122/97 -------------------------------------------------- Rv3903c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_1870|M.smegmatis_MC2_155 RATTLSDLLQPNMGAVDFVACLGSWNHRVFDVHGIYHQDTYDFIEKYPWP TH_3868|M.thermoresistible__bu -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK ---------- Mvan_2552|M.vanbaalenii_PYR-1 ---------- MMAR_3072|M.marinum_M ---------- MUL_2318|M.ulcerans_Agy99 ---------- MAV_2415|M.avium_104 ---------- Mb3933c|M.bovis_AF2122/97 ---------- Rv3903c|M.tuberculosis_H37Rv ---------- MSMEG_1870|M.smegmatis_MC2_155 EPENLGDDDW TH_3868|M.thermoresistible__bu ---------- MLBr_01556|M.leprae_Br4923 ---------- MAB_3131c|M.abscessus_ATCC_199 ----------