For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SRTKKSIVVVMMGSAGLFLSAPLLGPAANATPTRGGVPCVGILQQIVTRPGEIPQALTDTARSFTEPPKP APPVVRPPASSSSSAGTPPVPGRPPASVVTPSSGATPPVPPSPGTPASTSTRGGTPPVPPAPPAPAGTPA SGATPPAPPVPGVPAVTSTGGGTPPVPPVPGAPVGAPVANPGLPTPPVPGAPVFGDGGAVLPPLPPAPAG PAGGPAGLVAPPAPPVPGGPAAVPAGVALPPAPPGAPGAPVFGEAGAAPSGAAAPVAPAAGSGGAGGAGG GSGIGGPGGGGAPVEGTGGAVPAGAPLAAAGGEVPPPAPPIPGAPVIGEAGVVPPPAPPAPAPPAGGLGG AVPPPVPGAPGVPVVDEAGVVTPPAPGGPGVPTGGEGGVVTPPAPGAPGVPVVDEAGVVTPPAPGGPGVP TGGEGGVVTPPAPGAPGAPVVDEAGVVTPPAPGGPGVPAVGDTAVVTPPAPGAPGTPAVNSVETFSPPAP PAATPPSSGSVETFSPPAPPAPGTGTNSTVEISTPPPPGTPGLPSEGSTTYTTPPTPEITLNPANSGIDI ATPPAPGLPGAPLEATANITTPGTPGVPGAPVNSSIDVATPGEVGVPAAPIERSMTVTTPDTPGAPGAPA NAAVDVATPPAPGVPGAPVVGEAGVTTPGAPGAPGAPANAAVDVATPPAPGVPGAPVVGEAAVTTPGAPG VPGVPAGGDAGVVTPPAPGVPGAPVVGEAGVTTPGAPGVPGVPAGGDAGVVTPPAPGVPGAPAATEAGLA TPPGPGAPGAPVVGDAGVATPPGPGVPGAPIVDEAGLATPPAPVAPVEGAGGAVPPAGPPPAPVFGDAGA PVEAAAGGAPVEAAAGVTGGGSVAGAGAGGGAGGAAGGAGVEGASGAVGAAGGPGAGAAPAAAGGAAPGG APGGPVAGGGPVGGPGALPAPGAPIVGEAGVVSPPAPGVPGGAAAVPAGAVTPPAPGVPGAPVFGEAGVV TPPAPGVPGGAAAVPAGVVTPPAPGVPGGAAAVPAGAVTPPAPGVPGAPVFGDAGVATPPVPGVPGGGTT VPAASVTPPAPGVPGGASTVPGNAGTPSTPGLPPGSTDTYINYPAPPVPPTPPNSTGVSAGTPGSPAPGT PGSTLTLTDLLTPPGIARTLQNTASSVMGATPPGTPPVPGGSGSVSLAVPGTPSPIAPLAATGLSNLVSP PSLTIPSIPGLPVPLPNTVPVPSDLLCVGTDWSASQGDSAATPPAAEVPRVVTGAAPTGDRRDRWGNR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_3843 | - | - | 100% (1259) | hypothetical protein Mflv_3843 |
M. gilvum PYR-GCK | Mflv_5091 | - | 6e-33 | 28.26% (775) | triple helix repeat-containing collagen |
M. gilvum PYR-GCK | Mflv_4039 | infB | 1e-27 | 35.45% (268) | translation initiation factor IF-2 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3543 | PE_PGRS57 | 8e-54 | 31.10% (942) | PE-PGRS family protein |
M. tuberculosis H37Rv | Rv3514 | PE_PGRS57 | 1e-49 | 30.06% (968) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01556 | infB | 7e-17 | 34.48% (203) | translation initiation factor IF-2 |
M. abscessus ATCC 19977 | MAB_3131c | - | 8e-21 | 34.11% (258) | translation initiation factor IF-2 (InfB) |
M. marinum M | MMAR_5294 | - | 2e-53 | 30.30% (1152) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 3e-28 | 32.73% (333) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_5700 | - | 2e-30 | 33.41% (434) | secreted protein |
M. thermoresistible (build 8) | TH_4426 | - | 2e-32 | 35.41% (257) | PUTATIVE AAA ATPase |
M. ulcerans Agy99 | MUL_4367 | - | 8e-43 | 28.33% (1013) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_2552 | - | 0.0 | 62.38% (1175) | hypothetical protein Mvan_2552 |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_3843|M.gilvum_PYR-GCK MSRTKKSIVVVMMGSAGLFLSAPLLGPAANATPTRGGVPCVGILQQIVTR Mvan_2552|M.vanbaalenii_PYR-1 MSRTKKSIVVVMMGSAGLFLSAPLLGPSANATPTRGGVPCVGILQQVISR Mb3543|M.bovis_AF2122/97 -------MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQVLAAG Rv3514|M.tuberculosis_H37Rv -------MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQVLAAG MMAR_5294|M.marinum_M -------MSFVSVAPSLLDAAARDLAGLGAGLREANLAAAGATMGVLPAA MUL_4367|M.ulcerans_Agy99 -------MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAA MLBr_01556|M.leprae_Br4923 -----------MAGKARVHELAKELGVTSKEVLARLNEQGEFVKSASSTV MAB_3131c|M.abscessus_ATCC_199 -----------MAGKARVHELAKELGVTSKEVLARLSDQGEFVKSASSTV MSMEG_5700|M.smegmatis_MC2_155 -------------------MSGRHRKPTSSSSAKNVAKIAFTGAVLGGGG TH_4426|M.thermoresistible__bu ----------------VVRPAHPLYCAAVRAELTEPEVRGVRTELAGAAA MAV_4827|M.avium_104 ---------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADD Mflv_3843|M.gilvum_PYR-GCK PGEIPQALTDTARSFTEPPKPAPPVVRPPASSSSSAGTPPVPGRPPASVV Mvan_2552|M.vanbaalenii_PYR-1 PGDIPQALTETARSFTNPGQPAPPVVRPPASSSSSVGTPPVPPTPPGSVV Mb3543|M.bovis_AF2122/97 ADEVSARIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEAA Rv3514|M.tuberculosis_H37Rv ADEVSARIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEAA MMAR_5294|M.marinum_M GDEVSAAIAELFGGFGREYQAVGARMALLHDDFVRALTAGGSAYGQAEAL MUL_4367|M.ulcerans_Agy99 GDEVSAAIAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEAL MLBr_01556|M.leprae_Br4923 EAPVARRLRESFGGIKPAADKGAEQVATKAQAKRLGESLDQTLD------ MAB_3131c|M.abscessus_ATCC_199 EAPVARRLRESFGGGDKPAPAASNGAAAEAAAP----------------- MSMEG_5700|M.smegmatis_MC2_155 LGMAGQAMAATDGEWDQVARCESGGNWAINTGN----------------- TH_4426|M.thermoresistible__bu PTDVVGRLRWTLHALDSDAPPAAQQLTVAAEDALRLGDLGLCER------ MAV_4827|M.avium_104 AATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALR----- Mflv_3843|M.gilvum_PYR-GCK TPSSGATPPVPPSPGTPASTSTRGGTPPVPPAPPAPAGTPASGATPPAPP Mvan_2552|M.vanbaalenii_PYR-1 RPSSGATPPVPPTPGTPASTTTGVGTPPVPPTPPGSTVRPAAGATPPAPP Mb3543|M.bovis_AF2122/97 ------AAEQIVLGVINAPTQALLGRPLIGDGAN-ATTPGGAGGAGGLLF Rv3514|M.tuberculosis_H37Rv ------AAEQIVLGVINAPTQALLGRPLIGDGAN-ATTPGGAGGAGGLLF MMAR_5294|M.marinum_M NMWPLQELEQQALGVVNAPSMALFGRPLIGNGVDGVAGTGQAGGAGGILW MUL_4367|M.ulcerans_Agy99 NMWPLQELEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGILW MLBr_01556|M.leprae_Br4923 ------RALDKAVAGNGATTAAPVQVDHSAAVVPIVAGEGPSTAHREELA MAB_3131c|M.abscessus_ATCC_199 --------PKKAGPKPGAPKPAPKKVAEPVVEAPVAP-EPPAAPAAPAAP MSMEG_5700|M.smegmatis_MC2_155 --------GYHGGLQFSPSTWRAHGGTEFAPAAYMATKEEQIAVAERVLA TH_4426|M.thermoresistible__bu --------FGRAAVGAAGSGAGLAARLPLAYALAFQGRGREADEVLAAVD MAV_4827|M.avium_104 ----------DALAARRIDNVMLVSAFLAAAALAQNVGGAMGYERTAVLL Mflv_3843|M.gilvum_PYR-GCK VPGVPAVTSTGGGTPPVPP--VPGAPVGAPVANPGLPTPPVPGAPVFGDG Mvan_2552|M.vanbaalenii_PYR-1 VPGVPAGTPIGGGTPPLPP--VPGAPAGTPVANVAPPSPPVPGVPVIGDG Mb3543|M.bovis_AF2122/97 GNGGAGAAGAPGQAGGPGG--PAGLWGNGGPGGAGGSG-----GGTGGAG Rv3514|M.tuberculosis_H37Rv GNGGAGAAGAPGQAGGPGG--PAGLWGNGGPGGAGGSG-----GGTGGAG MMAR_5294|M.marinum_M GNGGNGGSGAAGANGGAGG--SAGLIGTGGVGGAGGVGAVGMAGGSGGAG MUL_4367|M.ulcerans_Agy99 GNGGNGGLGAAGANGGAGG--SAGLIGTGGVGGAGGVGAAGMTGGSGGAG MLBr_01556|M.leprae_Br4923 PPAGQPSEQPGVPLPGQQG--TPAAPHPGHPGMPTGPHPGPAPKPGGRPP MAB_3131c|M.abscessus_ATCC_199 APKPSPAARPAAAEAAAPA--PAPAPAP-RPGATPGPKPG-AP----RVP MSMEG_5700|M.smegmatis_MC2_155 SQGKGAWPTCGRGLSGATPRNVVAEPEPAPLDAPGVNGELPPPAPVDMLA TH_4426|M.thermoresistible__bu STGLTEHELMAWALPRAANQFWMLSQPERAVAFLRTVRERVSSPTAATTL MAV_4827|M.avium_104 VEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQLSAMVAGLEKLES Mflv_3843|M.gilvum_PYR-GCK GAVLPPLPPAPAGPAGGPAG------------------------------ Mvan_2552|M.vanbaalenii_PYR-1 GAALPPLPPVPGGPAAVPAG------------------------------ Mb3543|M.bovis_AF2122/97 GAGGWLFGVGGAGGVGG--------------------------------- Rv3514|M.tuberculosis_H37Rv GAGGWLFGVGGAGGVGG--------------------------------- MMAR_5294|M.marinum_M GSGGWLWGAGGAGGVGGAGGVGAGAGGIGGHGGAGGAGGVARSLLFGTGG MUL_4367|M.ulcerans_Agy99 GGGGWLWGAGGSG------------------------------------- MLBr_01556|M.leprae_Br4923 RVGNNPFSSAQSVAR----------------------------------- MAB_3131c|M.abscessus_ATCC_199 RVGNNPFSSAQPAER----------------------------------- MSMEG_5700|M.smegmatis_MC2_155 AP------------------------------------------------ TH_4426|M.thermoresistible__bu DALSATFAMNAGR------------------------------------- MAV_4827|M.avium_104 LPGGLLLVGSGVD------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M AGGAGGVGGGGVAGVDSGTPGGAGGGGGVGGAGGAGGVGGGSRSLLFGAG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -----------------------------------LVAPPAPPVPGGPAA Mvan_2552|M.vanbaalenii_PYR-1 -----------------------------------VVTPPAPPIPGGPAA Mb3543|M.bovis_AF2122/97 -------------------------------------AGGGTGGAGGPGG Rv3514|M.tuberculosis_H37Rv -------------------------------------AGGGTGGAGGPGG MMAR_5294|M.marinum_M GVGGEGASGGLGGGGGAGASGVGFDMAGGAGGDGGAGGAAGAGGAGGSGG MUL_4367|M.ulcerans_Agy99 -------------------------------------GAAGAGGSGGSGG MLBr_01556|M.leprae_Br4923 -------------------------------------PIPRPPAPRP--- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------PAPRPQAPRPGAP MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------MPAPEGLPPAPEA TH_4426|M.thermoresistible__bu ---------------------------------------PQQALQTATEV MAV_4827|M.avium_104 -------------------------------------VAPLKQVLQTTTF Mflv_3843|M.gilvum_PYR-GCK VPAGVALPPAPPGAPGAPVFGEAGAAPSGAAAPVAPAAGSGGAGGAGGGS Mvan_2552|M.vanbaalenii_PYR-1 MPAGVAAPPAP-APPGAPIFGEAGAVPPPGVGGAPLDGASGVAAPGGPGG Mb3543|M.bovis_AF2122/97 LIWG------GGGAGGVGGAGGG-----------TGGAGGRAELLFGAGG Rv3514|M.tuberculosis_H37Rv LIWG------GGGAGGVGGAGGG-----------TGGAGGRAELLFGAGG MMAR_5294|M.marinum_M WLWGNAGQTAGAGVGGAGGAGGAGGAGDHGVSSIAPGEAGAVGFAGGAGG MUL_4367|M.ulcerans_Agy99 WLWGNAGQTAGAGVGGAGGAGGAGDAGDQGVSGVAPGEAGAVGFAGGAGG MLBr_01556|M.leprae_Br4923 ---SASPSSMSPRPGGAVGGGGPR----------PPRTG-VPRPGGGRPG MAB_3131c|M.abscessus_ATCC_199 RPGGASPSNMPPRP--SPGSMGPR----------PPRPGGGPRPGGGPRP MSMEG_5700|M.smegmatis_MC2_155 LP-------------------------------PAPEALPPAPEAPAPAP TH_4426|M.thermoresistible__bu LASPTADGTAIGWAGAAAALS-------------AARMGRFTEVDALAER MAV_4827|M.avium_104 LDVSVAEEPETALARG-----------------AALAAANAPLFASSTAA . Mflv_3843|M.gilvum_PYR-GCK GIGGPGGGGAPVEGTGGAVPAGAPLAAAGGEVPPPAPPIPGAPVIGEAGV Mvan_2552|M.vanbaalenii_PYR-1 GAGAPGAPVAAAAGNAGPPAPGAPVGDQAGVVAPPAPPAPGAPVGDQAGL Mb3543|M.bovis_AF2122/97 AGGAGGAGTDGGPGATGGTGGHGGVGGDGGWLAPGG----AGGAGGQGGA Rv3514|M.tuberculosis_H37Rv AG---GAGTDGGPGATGGTGGHGGVGGDGGWLAPGG----AGGAGGQGGA MMAR_5294|M.marinum_M AGGAGGNGVGGGVNGAGGVGGAGGAGGGGGAGASGVGAGVAGGDGGTGGA MUL_4367|M.ulcerans_Agy99 AGGAGGNGVGGGVNGAGGAGGAGGVGGGGGAGASGVGAGVAGGDGGTGGA MLBr_01556|M.leprae_Br4923 APVGGRSDAGGGNYRGGGVG-ALPGGGS----GGFRGRPGGGGHGGGGRP MAB_3131c|M.abscessus_ATCC_199 GGAGRPGGGGGGNYRGGGTGTGAPAGGPPGAGGGFRGRPGGG--GGGGRP MSMEG_5700|M.smegmatis_MC2_155 EALPPAPEALPPAPEALPPAPEAPAPAPEALPPAPEAPAPVAEALPPAPE TH_4426|M.thermoresistible__bu AMSAGHPGLLRFTSGFGQTTARQLTGAPDQALALARRLTEIAQLQQPGRA MAV_4827|M.avium_104 LAYAQDPGTGAVDQYSLPDYLYVPVDPEPGDDELAYSAVGEEDAESPTVV Mflv_3843|M.gilvum_PYR-GCK VPPPAPPAPAPP-------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 VAPPGPPAPGVP-------------------------------------- Mb3543|M.bovis_AF2122/97 GGAGSDGGALG--------------------------------------- Rv3514|M.tuberculosis_H37Rv GGAGSDGGALG--------------------------------------- MMAR_5294|M.marinum_M GGAAGVGGAAGSGGVGGAAGVAGTGGDGGAGGSGGASDQGAAGVNPGEAG MUL_4367|M.ulcerans_Agy99 GGAAGVGGAAGTGGTG---------------------------------- MLBr_01556|M.leprae_Br4923 GQRGGAAGAFGR-------------------------------------- MAB_3131c|M.abscessus_ATCC_199 GQRGGAAGAFGR-------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 ALPPAPEAPPAP-------------------------------------- TH_4426|M.thermoresistible__bu IGELLIAEVLIT-------------------------------------- MAV_4827|M.avium_104 IEKLFLPEDSEP-------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M AVGFAGGAGGAGGAGGDSGAGGVNGSGGVGGAGGAGGGGGAGASGVGAGV MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK ------------------------------AGGLGGAVPPPVPGAPGVPV Mvan_2552|M.vanbaalenii_PYR-1 ------------------------------VVDQAGVVAPPGPPAPGVPV Mb3543|M.bovis_AF2122/97 --------------------------------GTGGTGGTGGAGGAGGRG Rv3514|M.tuberculosis_H37Rv --------------------------------GTGGTGGTGGAGGAGGRG MMAR_5294|M.marinum_M AGGDGGTGGAGGAAGVGGAAGSGGVGGAAGVAGTGGDGGDGGAGGAGSDA MUL_4367|M.ulcerans_Agy99 --------------------------GAAGVAGTGGDGGDGGAGGAGSDA MLBr_01556|M.leprae_Br4923 -----------------------------------PGGAPRRGRKSKRQK MAB_3131c|M.abscessus_ATCC_199 -----------------------------------PGGAPKRGRKSKRAK MSMEG_5700|M.smegmatis_MC2_155 ------------------------------------EALPPAPEAQIVDA TH_4426|M.thermoresistible__bu -----------------------------------RGDLDEAVALLRAAV MAV_4827|M.avium_104 ------------------------------------RRRPVLLVGSGLAV Mflv_3843|M.gilvum_PYR-GCK VDEAGVVTPPAPGGPGVPTGGEGGVVTPPAPGAPGVPVVDEAGVVTPPAP Mvan_2552|M.vanbaalenii_PYR-1 VDEAGVVTPPGPGAPGVPVVGEAGVVTPPGPGAPGVPVVDEAGVVTPPGP Mb3543|M.bovis_AF2122/97 ALLLGAGGQGGLGGAGGQGGMGGAGGA-GADNPTGIGGTGGDG------- Rv3514|M.tuberculosis_H37Rv ALLLGAGGQGGLGGAGGQGGTGGAGGD-GVLG--GVGGTGGKG------- MMAR_5294|M.marinum_M SVAGQAGFAGGSGGAGGVGGSAGAGGVNGSGGDGGAGAAGGAGGASATVA MUL_4367|M.ulcerans_Agy99 SLAGQAGFAGGSGGAGGVGGSAGAGGVNGSGGDGGAGAAGGAGGASATVA MLBr_01556|M.leprae_Br4923 RQEYDSMQAPVVGGVRLPHGNGETIRLARGASLSDFAEKIDAN------- MAB_3131c|M.abscessus_ATCC_199 RAEYENMQAPVVGGVRLPHGNGEVIRLARGASLSDFAEKIDAN------- MSMEG_5700|M.smegmatis_MC2_155 SLQVPADVPPAPPVEPAPPAPVDAVAAPENQNWDQAPAPADQP------- TH_4426|M.thermoresistible__bu KVLTPTGYSWAPLAAMLLARALGEQGAAPEAAIALSRAESRHG------- MAV_4827|M.avium_104 VGISAVLALEIALAIGIRTTGTVALQPTPNQHLIVPTEQAPAP------- Mflv_3843|M.gilvum_PYR-GCK GGPGVPTGGEGGVVTPPAPGAPGAPVVDEAGVVTPPAPGGPGVP------ Mvan_2552|M.vanbaalenii_PYR-1 GAPGVPVVDEAGVVTPPGPGAPGVPVVDEAGVVTPPAPGAPGVP------ Mb3543|M.bovis_AF2122/97 GTGGSAG--EGGAGGAAGQLFSAS---GAAGNAGVGGAGGQ--------- Rv3514|M.tuberculosis_H37Rv GVGGVAG--LGGAGGAAGQLFSAS---GAAGNAGVGGAGGQ--------- MMAR_5294|M.marinum_M GSGGVGG--DGGAGGAAGGGVGAAGLGGDGGHAGAGGAGGEGLSGGFNTG MUL_4367|M.ulcerans_Agy99 GSGGVGG--DGGAGGAAGGGVGAASLGGDGGHAGAGGAGGEGLSGGFNTG MLBr_01556|M.leprae_Br4923 ---------PAALVQALFNLGEMVTATQSVGDETLELLGSEMN------- MAB_3131c|M.abscessus_ATCC_199 ---------PASLVQALFNLGEMVTATQSVGDETLELLGGEMN------- MSMEG_5700|M.smegmatis_MC2_155 --------------------------QTWALHVGGPLPLDPVLP------ TH_4426|M.thermoresistible__bu ---------LKSMLFAPELALARAWTRAARGDRHGAVXXXXACWWWR--- MAV_4827|M.avium_104 ---------PPVQASAPQPKISVPEPVAAPKPLSPPVAAPLPAAP----- Mflv_3843|M.gilvum_PYR-GCK ---AVGDTAVVTPPAPGAPGTPAVNSVETFSPPAPPAATPPSS------- Mvan_2552|M.vanbaalenii_PYR-1 ---VDGGAELVTPPGPGAPGTPTVSSVETFSPPAPPAPGTPSS------- Mb3543|M.bovis_AF2122/97 -----GGDGGAGGAGADADQPGATGGTGFAGGAGGAGGAGGS-------- Rv3514|M.tuberculosis_H37Rv -----GGDGGAGGAGADADQPGATGGTGFAGGAGGAGGAGGS-------- MMAR_5294|M.marinum_M AAGGIGGAGGAGGTGGDSGGVGGVNGDGGAGGGGGRGGDGGSSTTVAGVG MUL_4367|M.ulcerans_Agy99 AAGGIGGAGGAGGTGGDSGGVGGVNGDGGAGGGGGRGGDGGS-------- MLBr_01556|M.leprae_Br4923 -----YNVQVVSPEDEDRELLEPFDLTYGEDQGDEDELQVR--------- MAB_3131c|M.abscessus_ATCC_199 -----YVVQVVSPEDEDRELLESFDLTYGEDEGGEEDLRTR--------- MSMEG_5700|M.smegmatis_MC2_155 -------APAPAPAPAPAPGAPAAVAAPAPDPLAPAPN------------ TH_4426|M.thermoresistible__bu ------WWDXXTPPGPPAPPAGGGGGGDVETPPGPPAPPAEVE------- MAV_4827|M.avium_104 -----PPAAPPLPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIP------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M GAGGAGGAGGDSGMVAGAGGTGGQAGDGGFGGFGGAGIDGGGAAGARGGD MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M GGAGGVGGAAEATGTGGAGGSGGAAGGGGSGASAVGAGLAGGAGGDGGIG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M GAAGAGGSGFVAGADGNGGFGGAGGAGGAGDQGVSGAAPGEAGAVGFAGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M AGGAGGAGGNGVGGGVNGAGGVGGAGGAGGGGGAGASGVGAGVAGGDGGA MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M GGAGGAAGVGGAAGSGGVGGAAGVAGTGGDGGAGGSGGASDQGAAGVNPG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M EAGAVGFAGGAGGAGGVGGDSGAGGVNGSGGVGGAGGAGGGGGAGASGVG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M AGVAGGDGGTGGAGGAAGVGGAAGTGGVGGAAGVAGTGGDGGAGGSGGAS MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M DQGAAGVNPGEAGAVGFAGGAGGAGGAGGDSGAGGVNGSGGVGGAGGAGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M GGGAGASGVGAGVAGGDGGTGGAGGAAGVGGAAGTGGVGGAAGVAGTGGD MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M GGAGGSGGASDQGAAGVNPGEAGTVGFAGGAGGAGGVGGDSGAGGVNGSG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M GVGGAGGAGGGGGAGASGVGAGVAGGDGGTGGAGGAAGVGGAAGSGGVGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M AAGVAGTGGDGGDGGAGGAGSDASVAGQAGFAGGSGGAGGVGGSAGAGGV MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M NGSGGDGGAGGTGGIGGASATTAGVGGAGGAGGAGGTTGGGVGAAGLGGD MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_5294|M.marinum_M GGHAGAGGAGGEGLSGGFNTGAAGGIGGAGGAGGTGGDSGGVGGVNGDGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK ----------GSVETFSPPAPPAPGTGTNSTVEISTPPPPGTPGLPSEGS Mvan_2552|M.vanbaalenii_PYR-1 ----------GSIETFSPPAPPTPGTPANSSVEIVTPPPPGVPGVPGEGS Mb3543|M.bovis_AF2122/97 -----------------SGAGGTNGSGGAGG-------TGGQGGMGGAGG Rv3514|M.tuberculosis_H37Rv -----------------SGAGGTNGSGGAG----------GQGGAGGAGG MMAR_5294|M.marinum_M AGGIGGRGGDGGSSTSTSGVGGAGGAGGNGGNAGFGVGAGGTGGSAGDGG MUL_4367|M.ulcerans_Agy99 -------------STSTSGVGGAGGAGGNGGNAGFGVSAGGTGGSAGDGG MLBr_01556|M.leprae_Br4923 -----------------PPVVTVMGHVDHG-------------------- MAB_3131c|M.abscessus_ATCC_199 -----------------PPVVTVMGHVDHG-------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK TTYTTP---------------------PTPEITLNPANSGIDIATPPAPG Mvan_2552|M.vanbaalenii_PYR-1 TTYTTP---------------------PTPEITLNPANSSIDVATPPGPG Mb3543|M.bovis_AF2122/97 AG---------------------------ADNPTGIGGTGGDGGTGGAAG Rv3514|M.tuberculosis_H37Rv AG---------------------------ADNPTGIGGTGGDGGTGGAAG MMAR_5294|M.marinum_M AGGFGGAGIDGSGAAGARGGDGGAGGGGGAGGVDGVGGASGNGGAAGAGG MUL_4367|M.ulcerans_Agy99 AG-------------------------GGAGGVDGVGGASGNGGAAGAGG MLBr_01556|M.leprae_Br4923 ----------------------------KTRLLDTIRKANVREAEAGG-- MAB_3131c|M.abscessus_ATCC_199 ----------------------------KTRLLDTIRKANVREGEAGG-- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK LPG------APLEATANITTPGTPGVPG-APVNSSIDVATPGEVGVPAAP Mvan_2552|M.vanbaalenii_PYR-1 VPG------VPVEASANVSTPPVPGVPG-APVNSSVEVATPAEVGVPGTP Mb3543|M.bovis_AF2122/97 AGG-------AGGAAGTGGTGGMIGTTGNAGVGGAGGQGGDGGAGGAGAD Rv3514|M.tuberculosis_H37Rv AGG-------AGGAAGTGGTGGMIGTTGNAGVGGAGGQGGDGGAGGAGAD MMAR_5294|M.marinum_M AGGSGIGAGIDGGAGGDGGIGGAAGFPGGGGTTGAWGTGGAGGAGGSGGA MUL_4367|M.ulcerans_Agy99 AGGSGIGAGIDGGAGGAGGTGGAAGFPGGGGTTGAWGTGGAGGAGGAGGA MLBr_01556|M.leprae_Br4923 ---------ITQHIGAYQVGVDLDGSERLITFIDTPGHEAFTAMRARGAK MAB_3131c|M.abscessus_ATCC_199 ---------ITQHIGAYQVAVEHDGTERPITFIDTPGHEAFTAMRARGAK MSMEG_5700|M.smegmatis_MC2_155 ---------------ADVAPTPPEGVPHLASPENLPPGTTETPDQIPGQG TH_4426|M.thermoresistible__bu --------------ERDDAEIPPGPPSPPAGGGGGGEIAPPPTPGEPGAV MAV_4827|M.avium_104 ---------VPDPVSPPQLLAPPRLSVPQPVQPPVRVPQPPSPPQVGGTV . Mflv_3843|M.gilvum_PYR-GCK IERSMTVTTPDTPGAPGAPANAAVDVATPPAPGVPGAPVVGEAGVTTPGA Mvan_2552|M.vanbaalenii_PYR-1 IERSTTLTTPPTPGVPGTPVNSSVEVATPPAPGAPGVPVVDEAGVVTPPG Mb3543|M.bovis_AF2122/97 ADQ------PGATGGTGFAGGAGGAGGAGGSSGAGGTNGSGGAGGTG--- Rv3514|M.tuberculosis_H37Rv ADQ------PGATGGTGFAGGAGGAGGAGGSSGAGGTNGSGGAGGTG--- MMAR_5294|M.marinum_M GDHGGVGVNPGDSGTAGWAGGAGGAGGAGGSAAVNGVNGAGGAGGNG--- MUL_4367|M.ulcerans_Agy99 GDHGGVGVNPGDSGTAGWAGGAGGAGGAGGSAAFNGVNGAGGAGGNG--- MLBr_01556|M.leprae_Br4923 ATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADP--- MAB_3131c|M.abscessus_ATCC_199 ATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADP--- MSMEG_5700|M.smegmatis_MC2_155 PNMTYLREIWHAIQTQDISGKDALLALTQRPLTTPDVPG----------- TH_4426|M.thermoresistible__bu IDQSSQNVTVPAPPTPGSETSTALEVFSPPVP------------------ MAV_4827|M.avium_104 PQSPPQHQTPPGEGTPPKPDGPGNYGGGHVPTPGAGGSGGSGGGHVP--- Mflv_3843|M.gilvum_PYR-GCK PGAPGAPANAAVDVATPPAPGVPGAPVVGEAAVTTPGAPGVPGVP-AGGD Mvan_2552|M.vanbaalenii_PYR-1 PGAPGVPVVGEAGVVTPPGPGAPGVPVVDEAGVVTPPGPGAPGVP-VVGE Mb3543|M.bovis_AF2122/97 -GQGGAGGAGGAGADNPTGIGGTGGDGGTGGAAGAGGAGGAAGTGGTGGM Rv3514|M.tuberculosis_H37Rv -GQGGAGGAGGAGADNPTGIGGTGGDGGTGGAAGAGGAGGAAGTGGTGGM MMAR_5294|M.marinum_M -GAGGGGGAGASGIG-AGVAGGDGGTGGTGGAAGTGGAAGTGGTGGAAGA MUL_4367|M.ulcerans_Agy99 -GAGGGGGAGASGIG-AGVAGGDGGTGGTGGAAGTGGAAGTGGTGGAAGA MLBr_01556|M.leprae_Br4923 --AKIRGQLTEYGLVAEDFGGDTMFIDISAKVGTNIEALLEAVLLTADAA MAB_3131c|M.abscessus_ATCC_199 --AKIRAQLTEYNLVAEDFGGDTMFVDISARQGTNIEQLLEAVLLTADAA MSMEG_5700|M.smegmatis_MC2_155 ------GAAPNRPVAPPPAPGDP-------ALAPAPAPLGAPAPAPAPEP TH_4426|M.thermoresistible__bu -----PGEVSGGGSNMLELPGFPGGTIGGPEIAHNVEVTGPPAEASVPGV MAV_4827|M.avium_104 --TPGAGGSGGSGGGHVPTPGTGGPGGTGGSGGGHVPTPGAGTPGGSGGG * Mflv_3843|M.gilvum_PYR-GCK AGVVTPPAPGVPGAPVVGEAGVTTPGAPGVPG------------------ Mvan_2552|M.vanbaalenii_PYR-1 AGVVTPPGPGAPGVPVVDEAGVVTPPGPGAPG------------------ Mb3543|M.bovis_AF2122/97 IGTTGNAGVGGAGGQGGDGGAG---------------------------- Rv3514|M.tuberculosis_H37Rv IGTTGNAGVGGAGGQGGDGGAGGAGADADQPGATGGTGFAGGAGGAGKAG MMAR_5294|M.marinum_M AGTAGDGGAGGAGGAGDDGSAGVVSGDPGTAG------------------ MUL_4367|M.ulcerans_Agy99 AGSAGDGGAGGAGGAGDDGSAGVVSGDPGTAG------------------ MLBr_01556|M.leprae_Br4923 LDLRANSGMEAQGVAIEAHLDR---------------------------- MAB_3131c|M.abscessus_ATCC_199 LDLRANPDMEAQGVAIEAHLDR---------------------------- MSMEG_5700|M.smegmatis_MC2_155 APVGAPAPVGAPVPPPA--------------------------------- TH_4426|M.thermoresistible__bu DASVATEAGTPPVPP----------------------------------- MAV_4827|M.avium_104 HLPFPGAGSTPGGSGGGHLPTP---------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv GSSSAGGTNSSGSAGGTGRQSGTGGAGGAGADNPTGIGGTGGDGGTGGAA MMAR_5294|M.marinum_M -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK --------------------VPAGGDAGVVTPPAPGVPGAPAATEAGLAT Mvan_2552|M.vanbaalenii_PYR-1 --------------------VPVVGEAGVVTPPGPGAPGVPVVDEAGVVT Mb3543|M.bovis_AF2122/97 ------------------------GAGGAGGSSGAGGTNG----SGGAGG Rv3514|M.tuberculosis_H37Rv GAGGAGGAAGTGGTGGMIGTTGNAGVGGAGGSSGAGGTNG----SGGAGG MMAR_5294|M.marinum_M ------------------------KAGGAGGAGGAGGNGV----AGGANG MUL_4367|M.ulcerans_Agy99 ------------------------KAGGAGGAGGVGGNGV----AGGVNG MLBr_01556|M.leprae_Br4923 ------------------------GRGPVATVLVQRGTLR-------IGD MAB_3131c|M.abscessus_ATCC_199 ------------------------GRGPVATVLIQRGTLR-------VGD MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PPGPGAPGAPVVGDAGVATPPGPGVPGAPIVDEAGLATPPAP-----VAP Mvan_2552|M.vanbaalenii_PYR-1 PPGPGAPGVPVVDEAGVVTPPGPGAPGVPVVDEAGVVTPPAPPAAAPGAP Mb3543|M.bovis_AF2122/97 TGGQGGAGG----AGGAGADNPTGIGG--TGGDGGTGGAAGAGGAGGAAG Rv3514|M.tuberculosis_H37Rv TDGQGGAGG----AGGAGADNPTGIGG--TGGDGGTGGAAGAGGAGGAAG MMAR_5294|M.marinum_M SGGAGGAGG----AGGTGGAGASGVPASVAGGDGGAGGAGGAAGSGGAAG MUL_4367|M.ulcerans_Agy99 SGGAGGAGG----AGGTGGAGASGVPASVDGGDGGAGGAG------GAAG MLBr_01556|M.leprae_Br4923 SVVAGDAYGRVRRMVDEHGVDIEAALPSSPVQVIGFTSVPGAGDNFLVVD MAB_3131c|M.abscessus_ATCC_199 SIVAGDAYGRVRRMVDEHGEDVEEALPSRPVQVIGFTSVPGAGDNLLVVD MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -----GPTAPIEHAAETSVPAEVEIPGAEIDHRAEVATPPVDGPPVEVEN MAV_4827|M.avium_104 --GAGTPGG------GLGGFGGGHAPAPGGGLGGGGGHAPAPGGGLGGFG Mflv_3843|M.gilvum_PYR-GCK VEGAGGAVPPAGPPPAPVFGDAG---------------APVEAAAGGAPV Mvan_2552|M.vanbaalenii_PYR-1 IDAAAASVAPSGPPAAPVLGEAG---------------VVAPPAP----- Mb3543|M.bovis_AF2122/97 TGGTGGMIGTTGNAGVGG-------------------------AGGQG-- Rv3514|M.tuberculosis_H37Rv TGGTGGMIGTTGNAGVGG-------------------------AGGQG-- MMAR_5294|M.marinum_M TGGSGGSAGNTGAGGAGGDGGVGGAGGNAEGPGLFGYDGGMGGAGGAGGS MUL_4367|M.ulcerans_Agy99 TGGSGGSAGNTGAGGAGG-------------------------AGGAGGS MLBr_01556|M.leprae_Br4923 EDRIARQIADRRSARKRN-------------------------------- MAB_3131c|M.abscessus_ATCC_199 EDRIARQIADRRSARKRN-------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu SVEVATPPHXXGPGAVVDX------------------------------- MAV_4827|M.avium_104 GGHSGGGLGGLGGGHK---------------------------------- Mflv_3843|M.gilvum_PYR-GCK EAAAGVTGGGSVAGAGAGGGAGGAAGGAGVEGASGAVGAAGGPGAGAAPA Mvan_2552|M.vanbaalenii_PYR-1 ------PGGGAPGGGAPGAGVG---TGAPIEGAAGAGGVPAAPLAANAGA Mb3543|M.bovis_AF2122/97 -------GDGGAGGAGADADQPGATGGTGFAGGAGGAGG----------- Rv3514|M.tuberculosis_H37Rv -------GDGGAGGAGADADQPGATGGTGFAGGAGGAGGSGGSSCAGGTN MMAR_5294|M.marinum_M AGSTGVNGDGGAGGAGGVGGLGGDSAATAGGGGAGGDGGAGGAAGAGAGI MUL_4367|M.ulcerans_Agy99 AASTGVNGDGGAGGAGGVGGLGGDSAATAGGGGAGGDG------------ MLBr_01556|M.leprae_Br4923 -----------ALAARSRKRISLEDLDSALKETSQLNLILK--------- MAB_3131c|M.abscessus_ATCC_199 -----------ALAARSRKRISLDDLDAALKETSQLNLILK--------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK AAGGAAPGGAPGGPVAGGGPVGGPGALPAPGAPIVGEAGVVSPPAPGVPG Mvan_2552|M.vanbaalenii_PYR-1 AT---PPAAATGG----------------AGAPIDAAAGAAAPPAP---- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv GSGGAGGTCGQVVAGGAGISFSNGSNGGTGGTGGVGGTGGDGGNAGTGAG MMAR_5294|M.marinum_M AGSAGDGGHAGAGGAGGAGLSGGFNTGAAGGIGGAGGAGGTGGDSGGVGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK GAAAVPAGAVT--------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv DPGKGGTGGTGGTGGSGGA------------------------------- MMAR_5294|M.marinum_M VNGDGGAGGIGGHGGDGGSSTSTPGVGGAGGAGGDGGSAGIGVGVAGNGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv ------------GGSGGANFNGGTGGTGGTGGKGGLNTDGLSSATSGTGG MMAR_5294|M.marinum_M DAGAGGAGGSGGAGIDGSAATGAHGGAGGSGGVGGQATNSAGVGGDGGAG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv TGGTGGKGGTGGAGDDSAGGTGGTGGAGGNAGAGGLANTGGTAGNAGIGG MMAR_5294|M.marinum_M GAGGNGGAGANGTASPGVPGPGAGGDAGAGGNGGAGGGSGARNGDGGDGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 --------------------------------AGGSS------------- Rv3514|M.tuberculosis_H37Rv DGGQGGNGGQGDSGSGLGGQPGFAGGAGGKGGAGGSS------------- MMAR_5294|M.marinum_M VGGRGGDGHIHPGGSRINGGDGGVGGAAGLAGVNGASAAGNAGHGGDGGA MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK --------------PPAPGVPGAPVFGEAGVVTPPAPGVPGGAAAVPAGV Mvan_2552|M.vanbaalenii_PYR-1 ---------------PAP---GAPIFGEAGVAAPPLPPAPGGAGAVPAGV Mb3543|M.bovis_AF2122/97 --------------GAGGTNGSGGAGGTGGQGGAGGAGISFSNGSNGGTG Rv3514|M.tuberculosis_H37Rv --------------GAGGTNGSGGAGGAGGQGGAGGAGISFSNGSNGGTG MMAR_5294|M.marinum_M GGNGSVGAAGADGVGAGATGGFGSQGGDGGKGGAGGAGVNGVGGGDGGKG MUL_4367|M.ulcerans_Agy99 -----------------------------GKGGAGGAGVNGVGGGDGGKG MLBr_01556|M.leprae_Br4923 -----------------------------GDNAGTVEALEEALMGIQVDD MAB_3131c|M.abscessus_ATCC_199 -----------------------------GDNAGTVEALEEALLGIAIDD MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------XXXRRPGADPRPXPLPVAA MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK VTPPAPGVPGGAAAVPAGAVTPPAPGVPGAPVFGDAGVATPPVPGVPGGG Mvan_2552|M.vanbaalenii_PYR-1 VTPPVPGVPGGAGAVPAGAVTPPTP----------------PVPGSSSGG Mb3543|M.bovis_AF2122/97 GTGGVGGTGGDGGNAGTGAGDPGKGGTG---------------------- Rv3514|M.tuberculosis_H37Rv GTGGVGGTGGDGGNAGTGAGDPGKGGTGGTGGTGGSGGAGGSGGANFNGG MMAR_5294|M.marinum_M GSGGTGGAGGAGG-AGSDGILPSNGGLGGLGGSGGLGGAGGAGTDGGASG MUL_4367|M.ulcerans_Agy99 G---TGGAGGAGG-AGSDGIIPSNGGLG---------------------- MLBr_01556|M.leprae_Br4923 EVALRVIDRGVGGITETNVN------------------------------ MAB_3131c|M.abscessus_ATCC_199 EVQLRVIDRGVGGVTETNVN------------------------------ MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu QLHPRPVG------------------------------------------ MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK TTVPAASVTPPAPGVPGGASTVPGNAGTPSTPGL---------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv TGGTGGTGGTGGKGGMGGIAGDGGPGGDGGNAGVGGKGGTNGNGGSGGTG MMAR_5294|M.marinum_M ATGTYGNGGTGGAGGAGGNA------------------------------ MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv GTGGAGGNAGAGGLANTGGTAGNAGIGGDGGQGGNGGQGDSGSGLGGQPG MMAR_5294|M.marinum_M -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2552|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv FAGGPGGKGGAGGNAGTGGTNGSGAGGAGGQGGAGGAGISFSNGSNGGTG MMAR_5294|M.marinum_M -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK ---------------------PPGSTDTYINYPAPPVPPTPPNSTGVSAG Mvan_2552|M.vanbaalenii_PYR-1 ----------------------------FVNYPAPPVPPTPPNSAGVNTG Mb3543|M.bovis_AF2122/97 -------------------------------GTGGSGGAGGSGGANFNGG Rv3514|M.tuberculosis_H37Rv GTGGVGGTGGDGGNAGTGAGDPGKGGTGGTGGTGGSGGAGGSGGANFNGG MMAR_5294|M.marinum_M --------------------------TGGAGEGGGLGGNGGTGGQAFGDG MUL_4367|M.ulcerans_Agy99 ----------------------------------GNGGNGGNGGQAFGDG MLBr_01556|M.leprae_Br4923 -----------------------------------LASASDAIIIGFNVR MAB_3131c|M.abscessus_ATCC_199 -----------------------------------LASASDAIIIGFNVR MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu -----------------------------------CDGPRRPHRGGVVTA MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK TPGSPAPGTPGSTLTLTDLLTPPGIARTLQNTASS------VMGATPPGT Mvan_2552|M.vanbaalenii_PYR-1 TPGSPIPGTPGSTLTISDLLTPPGVARTVQNTASS------VMSIAPPGT Mb3543|M.bovis_AF2122/97 TGGTGGTGGTGGKGGMGGIAGDGGPGGDGGNAGVG-----GKGGTNGNGG Rv3514|M.tuberculosis_H37Rv TGGTGGTGGTGGKGGMGGIAGDGGPGGDGGNAGVG-----GKGGTNGNGG MMAR_5294|M.marinum_M VGGAGGIGGKGGNAAIGTLVVNGGVGGAGGSGGLGGATENGVGGVGGAGG MUL_4367|M.ulcerans_Agy99 VGGAGGIGGKGGNAAIGTIVINGGVGGAGGSGGLGGATEDGVGGVGCAGG MLBr_01556|M.leprae_Br4923 AEGKATELASREGVEIRYYLVIYQAIDDIEKALRG--------------- MAB_3131c|M.abscessus_ATCC_199 AEGKATELANREGVDIRYYSVIYQAIDEIESALKG--------------- MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu SRQPRRLTGRVDAPHLHRHRGQPGDAQHQHGHHRR------------QRE MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PPVPGGSGSVSLAVPGTPSPIAPLAATGLSNLVSPPSLTIPSIPGLPVPL Mvan_2552|M.vanbaalenii_PYR-1 PPVPGGAGSVSVGVPAPPSPLTPLAATGLSNLVSPPSLTIPSIPGLPVPL Mb3543|M.bovis_AF2122/97 SGGTGGTG----GPGGSGGAPTGSGTGGKGGAGGDGGDGADGGAATGVGD Rv3514|M.tuberculosis_H37Rv SGGTGGTG----GPGGSGGAPTGSGTGGKGGAGGDGGDGADGGAATGVGD MMAR_5294|M.marinum_M AGGNGGRGDTLFTAGGSGGTGGHGGGGGSASGSGTGGSGGTGGVGGIGGD MUL_4367|M.ulcerans_Agy99 AGGNGGRGDMLFTVGGSGGTGGDGGGGGSASGSGTGGSGGTGGVGGIGGD MLBr_01556|M.leprae_Br4923 -MLKPIYEENQLGRAEIRALFRSSKVGIIAGCIISSGVVRRNAKVRLLRD MAB_3131c|M.abscessus_ATCC_199 -MLKPVYEEVELGRAEIRAMFRSSKVGNIAGCLVTSGIIRRNAKARLLRD MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu RGFHGDRATITHTLVFNARLMMLVSALTIESPVTTAYRMAPNAAAAIVPT MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PNTVPVPSDLLCVGTDWSASQGDSAATPPAAEVPR-VVTGAAPTGDRRDR Mvan_2552|M.vanbaalenii_PYR-1 PNEVPVPSDLLCVGTDWSATQGDSATTPVNAEIPRALVTGAAPVGDRRDR Mb3543|M.bovis_AF2122/97 GGDGGNGGNGGNGGTG-VGSPGGLGGAGGTGGLGGAGAGGGADGDDGDDG Rv3514|M.tuberculosis_H37Rv GGDGGNGGNGGNGGTG-VGSPGGLGGAGGTGGLGGAGAGGGADGDDGDDG MMAR_5294|M.marinum_M GKVGGSGGDGGDGGDGGSGVIGGQGGGGGIGGFGGTGAGG-APSDNGTNG MUL_4367|M.ulcerans_Agy99 GKLGGFGGDGGDGGDGGFGVIGGQGGGGGFGGLGGTGAGG-APSDKGING MLBr_01556|M.leprae_Br4923 NIVVTDNLTVTSLRREKDDVTEVREGFECGMTLGYSDIKEGDVIESYELV MAB_3131c|M.abscessus_ATCC_199 NIVVAETVTISSLRREKDDVVEVRDGYECGLTLTYNDIKEGDVIEAYELR MSMEG_5700|M.smegmatis_MC2_155 -------------------------------------------------- TH_4426|M.thermoresistible__bu AYSTVDIPASSTINIVVLA------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK WGNR--- Mvan_2552|M.vanbaalenii_PYR-1 WDTR--- Mb3543|M.bovis_AF2122/97 QPGNNGS Rv3514|M.tuberculosis_H37Rv QPGNNGS MMAR_5294|M.marinum_M EPGNPG- MUL_4367|M.ulcerans_Agy99 EPGNPG- MLBr_01556|M.leprae_Br4923 EKQRA-- MAB_3131c|M.abscessus_ATCC_199 EKERV-- MSMEG_5700|M.smegmatis_MC2_155 ------- TH_4426|M.thermoresistible__bu ------- MAV_4827|M.avium_104 -------