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RVAVTGAGGVLGRGLASRLLSQGHEVVGMSRRRPDSWPSQADFVAGDIRDAAAVRRAITGADVVAHCAWA RNPGPDGRISQQINIDGTRNVLDAMAACGTGRIVFPSSPHVYRPGVPMPATEHGAVAPASAEGRHKAGVE QMLQESGAQWVAVRSALIVGRNIDNWVRRLFALPAFPDGSADDVLQVVHLDDVLRLLTRAVSDVGAGTGP VNLAAPGLPTLREIAMALRRPILPVGAVLRRIGSVAEFQLVQGVPVMDTARLHDEWKFQPAFTAEESVED FALAVRGRVSLGRRVVSLPWRLANIQDLPAVDAPAQDGVVPRLAGPEGVNGEFDTPIDPRFPTFLATNLS EALPGPFSPSSASVTVRGLRAGGVGIAERLRPGGVIQREIAMRTVAVFAHRLYGAITSAHFMAETVPFAK PAMIVSNSGFFGPSMGSLPIFGEERPPAESSFVRRQLRTVRNIGVFGVNLVGLSAGSALDTNDFIADVDR LEQLAGGDVTTLDDRRLLSLILLARDHVVHGWVLASGSFMLCAAFNVLLRAVSGRDTAPAAGPELVSARS VEAVQRLVAAARHDEAVIRLLSEPGDRLGKLAVAAPHFYDAVRQELSLIGHRGPAEVEMMSTSYADNPEL LVGMVAKTLSTSSVPQPPQPSIPLQAKPIAVLAARQLRDREARRDKMVRAIWVLRALLREHGRRLAEAGV LHASDDVFYLLVDELDALPADVAELVARRRAEQRRLTAVVPPTVFSGKWEPSTASAAALTAGGTLRGVGV CGGRVRGRVRIVRPETIDELEPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVD AQGATRFLPPGALIEVDGTTGEIQVLELAAEGDSSVTQSDPADLA*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3024 | - | - | 100% (886) | hypothetical protein MMAR_3024 |
M. marinum M | MMAR_2747 | - | 1e-62 | 29.10% (763) | hypothetical protein MMAR_2747 |
M. marinum M | MMAR_1810 | galE4 | 6e-14 | 27.93% (333) | UDP-glucose 4-epimerase, GalE4 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2073c | - | 0.0 | 76.08% (882) | hypothetical protein Mb2073c |
M. gilvum PYR-GCK | Mflv_0493 | - | 3e-40 | 30.98% (581) | pyruvate, water dikinase |
M. tuberculosis H37Rv | Rv2047c | - | 0.0 | 76.08% (882) | hypothetical protein Rv2047c |
M. leprae Br4923 | MLBr_00955 | ppdK | 2e-10 | 30.11% (186) | pyruvate phosphate dikinase |
M. abscessus ATCC 19977 | MAB_2971c | - | 1e-13 | 32.95% (173) | putative oxidoreductase |
M. avium 104 | MAV_2451 | - | 0.0 | 72.94% (872) | hypothetical protein MAV_2451 |
M. smegmatis MC2 155 | MSMEG_3934 | - | 1e-19 | 41.91% (136) | phosphoenolpyruvate synthase |
M. thermoresistible (build 8) | TH_4555 | - | 1e-25 | 29.39% (313) | PUTATIVE putative phosphoenolpyruvate synthase |
M. ulcerans Agy99 | MUL_2265 | - | 0.0 | 98.98% (886) | hypothetical protein MUL_2265 |
M. vanbaalenii PYR-1 | Mvan_1818 | - | 2e-31 | 26.73% (808) | pyruvate, water dikinase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0493|M.gilvum_PYR-GCK -------------------MFDASSRIVDLADVLDDSFGGKALGLAELTR Mvan_1818|M.vanbaalenii_PYR-1 ----------------------MAPATIEFDDVTDDRFGGKAAGLAELRR MMAR_3024|M.marinum_M MRVAVTGAGGVLGRGLASRLLSQGHEVVGMSRRRPDSWPSQADFVAGDIR MUL_2265|M.ulcerans_Agy99 MRVAVTGAGGVLGRGLASRLLSQGHEVVGMSRRRPDSWPSQADFVAGDIR Mb2073c|M.bovis_AF2122/97 MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPSSADFIAADIR Rv2047c|M.tuberculosis_H37Rv MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPSSADFIAADIR MAV_2451|M.avium_104 MRIAVTGASGVLGRGLAARLLSKGHDVVGIARHRPDSWSSAADFIEADIR TH_4555|M.thermoresistible__bu -MMTDMSAVTSPNTVEAEHTVSNVIRFADPGATDPRLVGGKGMNLGELVA MAB_2971c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_3934|M.smegmatis_MC2_155 ---------------MDIMSDRYVRTLDILTIADAEEAGGKGANLGELVA MLBr_00955|M.leprae_Br4923 ------------------MPGQSHKEPHRRATSTPRSLKQATSELRWALS Mflv_0493|M.gilvum_PYR-GCK LGLPVPPGFVIADASGTS----------------LGDAVTERFSRMRAAG Mvan_1818|M.vanbaalenii_PYR-1 IGLSVPVGFVIADASAHG----------------ALDAAVDRFCQMAAEG MMAR_3024|M.marinum_M DAAAVRRAITGADVVAHCAWARNPGPDGRISQQINIDGTRNVLDAMAACG MUL_2265|M.ulcerans_Agy99 DAAAVRRAITGADVVAHCAWARNPGPDGRISQQINIDGTRNVLDAMAACG Mb2073c|M.bovis_AF2122/97 DATAVESAMTGADVVAHCAWVRGR------NDHINIDGTANVLKAMAETG Rv2047c|M.tuberculosis_H37Rv DATAVESAMTGADVVAHCAWVRGR------NDHINIDGTANVLKAMAETG MAV_2451|M.avium_104 DAAAVNRAVTSADVVAHFAWTHDT--QERTGSQVNIAGTANVLAAMAETS TH_4555|M.thermoresistible__bu AGFRVPNGFTVSTEAYAATLADSGAADRIFELLKGLDVADLARLESTAAA MAB_2971c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_3934|M.smegmatis_MC2_155 ADLPVPHGFVVMRSAYLDSVRMGGVEAELAALHTEALTHAADTARLSELC MLBr_00955|M.leprae_Br4923 LAAPESPAFMRHLLGNAH----------------DKVDITTSSEHVAAFT Mflv_0493|M.gilvum_PYR-GCK QTPVAVRSS--------------------------------AAGEDGAEH Mvan_1818|M.vanbaalenii_PYR-1 VTPVAVRSS--------------------------------AVGEDGEDQ MMAR_3024|M.marinum_M TGRIVFPSSPHVYRPGVPMPATEHGAVAPASAEGRHKAGVEQMLQESGAQ MUL_2265|M.ulcerans_Agy99 TGRIVFPSSPHVYRPGLPMPATEHGAVAPASAEGRHKAGVEQMLQESGAQ Mb2073c|M.bovis_AF2122/97 TGRIVFTSS-------------------------GHQPRVEQMLADCGLE Rv2047c|M.tuberculosis_H37Rv TGRIVFTSS-------------------------GHQPRVEQMLADCGLE MAV_2451|M.avium_104 ARRIVFPSSPHVYGGG-DTPRSEAEAPAPSAADAVQQARVEEMLVASGLE TH_4555|M.thermoresistible__bu IRDVVTAVELP-----DKLAHDIERAYTELGADVYVAVRSSGTAEDTAEA MAB_2971c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_3934|M.smegmatis_MC2_155 RRMQSLVNKAG---LSPSVRDATLAAYRALGTDVVVAVRSSATGEDGRDA MLBr_00955|M.leprae_Br4923 EHAIVLLNG-----------------------------------NAHQTR Mflv_0493|M.gilvum_PYR-GCK SFAGQYDTVLG---VGSVDELTAAVEKCVRSAGSER-AAAYQDGGAAARM Mvan_1818|M.vanbaalenii_PYR-1 SFAGQYDTVLG---VASVDDFTAAVRRCAGSVASQR-ASSYS-GHSPATM MMAR_3024|M.marinum_M WVAVRSALIVGRNIDNWVRRLFALPAFPDGSADDVL-QVVHLDDVLRLLT MUL_2265|M.ulcerans_Agy99 WVAVRSALIVGRNIDNWVRRLFALPAFPDGSADDVL-QVVHLDDVLRLLT Mb2073c|M.bovis_AF2122/97 WVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVV-QVVHSDDAQRLLV Rv2047c|M.tuberculosis_H37Rv WVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVV-QVVHSDDAQRLLV MAV_2451|M.avium_104 SVTIRCALVVGRNVDNWVRRVLALPAFPGGTVDRPI-QLVHLDDALRLLE TH_4555|M.thermoresistible__bu SFAGMHDTYLDIRGTGEVLDAVRRCWASMWTARAVAYREEHGFDHREAKI MAB_2971c|M.abscessus_ATCC_199 ------MRVLVTGGTGFVGGWTAKAMAEAG-------------HKVRFLV MSMEG_3934|M.smegmatis_MC2_155 SFAGMNRTITNVMGEVALLDAVTQCWMSLFSPRVIT-YRASRGFTAAPAM MLBr_00955|M.leprae_Br4923 ELLGGKGYNINAMRRHQLAVPPAFCITTEVGVRYLA--------APTPTM : Mflv_0493|M.gilvum_PYR-GCK HLVVQQMVDARAAGVVFTADPTSGRRDLLVIDAVRGLGESLVDGSTASDH Mvan_1818|M.vanbaalenii_PYR-1 HVVVQQMVDARAAGVVFTADPATGRRDLMVIDAIAGLGEALVDGSASPDH MMAR_3024|M.marinum_M RAVSDVGAGTGPVNLAAPGLPTLREIAMALRRPILPVG-AVLRRIGSVAE MUL_2265|M.ulcerans_Agy99 RAVSDVGAGTGPVNLAAPGLPTLREIATALRRPILPVG-AALRRIGSVAE Mb2073c|M.bovis_AF2122/97 RALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSFAE Rv2047c|M.tuberculosis_H37Rv RALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSFAE MAV_2451|M.avium_104 SAVLSHEIPSGTVNLAAPGTTTFRRIAATLRRPVLRLG------RPAPAE TH_4555|M.thermoresistible__bu AVVVQTMAEADVSGVMYTANPLNNRTDEIVINSAYGLGESIVSGAINPDE MAB_2971c|M.abscessus_ATCC_199 RKEARLHTTVATLGVDVSDYAVG--------------------------- MSMEG_3934|M.smegmatis_MC2_155 AVVVQQMLSADRAGVAFTSDPSTGDADHIVIEAAFGQGEVVVSGKVEPDT MLBr_00955|M.leprae_Br4923 EAIWNDVLDQMRWLEAETSRTFGWGPRPLLVSIRSG-------------- . Mflv_0493|M.gilvum_PYR-GCK FVLTHAG-----DTVTTEAS----------------------SQPALADD Mvan_1818|M.vanbaalenii_PYR-1 VVLNADG-----STAVREVG----------------------TAPVLSSD MMAR_3024|M.marinum_M FQLVQGVPVMDTARLHDEWK----------------------FQPAFTAE MUL_2265|M.ulcerans_Agy99 FQLVQGVPVMDTARLHDEWK----------------------FQPAFTAE Mb2073c|M.bovis_AF2122/97 LELLHSAPLMDVTLLRDRWG----------------------FQPAWNAE Rv2047c|M.tuberculosis_H37Rv LELLHSAPLMDVTLLRDRWG----------------------FQPAWNAE MAV_2451|M.avium_104 LEPVLSAPLMDTALLHERWG----------------------FRPAWQCG TH_4555|M.thermoresistible__bu FTVDLGTLKIKQANVGNKKEKIVRAPDKPSGTVTLAVSEEDAGRLSLTDE MAB_2971c|M.abscessus_ATCC_199 -------------DITDRAS----------------------VEAALDGC MSMEG_3934|M.smegmatis_MC2_155 YVIDKRTLEVRDVRIGFKAIKIVRGDDGADSMVQLERSQ---AEARVLDD MLBr_00955|M.leprae_Br4923 -------------AVQSMPG---------------------------MMD Mflv_0493|M.gilvum_PYR-GCK EIDRIRTGALLAAAHWG-RPLDLEWAIDRDGLLWWLQARPITTLP----- Mvan_1818|M.vanbaalenii_PYR-1 DVAEIRSGALRAARHWG-RPLDLEWAIDGTGKLWWLQARPITTLP----- MMAR_3024|M.marinum_M ESVEDFALAVRGRVSLGRRVVSLPWRLANIQDLPAVDAPAQDGVVPRLAG MUL_2265|M.ulcerans_Agy99 ESVEDFALAVRGRVSLGRRVVSLPWRLANIQDLPAIDASAQDGVVPRLAG Mb2073c|M.bovis_AF2122/97 ECLEDFTLAVRGRIGLGKRTFSLPWRLANIQDLPAVDSPADDGVAPRLAG Rv2047c|M.tuberculosis_H37Rv ECLEDFTLAVRGRIGLGKRTFSLPWRLANIQDLPAVDSPADDGVAPRLAG MAV_2451|M.avium_104 ECVEDMALAVRGRVTVGRRVVSLPWRLANVADLPAVDAPAQDGVVPVPAG TH_4555|M.thermoresistible__bu QVAELAALGRQVMDHYGGLPQDIEWACVD-GEFFLLQTRPITGAKFTWP- MAB_2971c|M.abscessus_ATCC_199 DAVVHSAAMVSTDPAEADRMMAINLEGTRNVLGAAVDR------------ MSMEG_3934|M.smegmatis_MC2_155 DALRKIATLAVATETHNGCPQDIEWVIAD-GAVWLVQARPITTLG----- MLBr_00955|M.leprae_Br4923 TILNLGINDPVEQALAAASPSPIPQTFARDTRLRFIRTYRRIVDP----- : : Mflv_0493|M.gilvum_PYR-GCK --GDPNEMDTPVTGPTHVYTRCNIGEMMPGAFCPLTASVSGHAIDY-AMQ Mvan_1818|M.vanbaalenii_PYR-1 --GDLNEMDSPVAGSDHVYTRCNIGEMMPGAFCPLTASVSGYAIDY-AMQ MMAR_3024|M.marinum_M PEGVNGEFDTPIDPRFPTFLATNLSEALPGPFSPSSASVTVRGLRAGGVG MUL_2265|M.ulcerans_Agy99 PEGVNGEFDTPIDPRFPTFLATNLSEALPGPFSPSSASVTVRGLRAGGVG Mb2073c|M.bovis_AF2122/97 PEGANGEFDTPIDPRFPTYLATNLSEALPGPFSPSSASVTVRGLRAGGVG Rv2047c|M.tuberculosis_H37Rv PEGANGEFDTPIDPRFPTYLATNLSEALPGPFSPSSASVTVRGLRAGGVG MAV_2451|M.avium_104 PEGVNGEFDTPIDPRFPTFLATNLSEALPGPFSPSSASATVRGVRAGGVT TH_4555|M.thermoresistible__bu --EGFNDWQNGPEDPDTLWTFKYAEQYWTGGITPLFFSVRARETQVGYDR MAB_2971c|M.abscessus_ATCC_199 -------------GLDPIVHVSSITALFRPGLETFAADLPAAGGSDGYGQ MSMEG_3934|M.smegmatis_MC2_155 ----SAGSTAGDEPSVLIRGLPAAPGVASGRVRVLLAPDDGDKLTDGEIL MLBr_00955|M.leprae_Br4923 --------LNPPPANTYDQLRAAIESIFSSWNSPRAVAYRTHYGLDDQSG Mflv_0493|M.gilvum_PYR-GCK MVQVAGGVQERYEDRARQVGYFFGHMFLNMTEGTALSSGILG-NSLEQFS Mvan_1818|M.vanbaalenii_PYR-1 MTQVVARAQPRYEKPWLQVGYFYGHMFLNLTEGTALSSGILG-NSREQFS MMAR_3024|M.marinum_M IAERLRPGGVIQREIAMRTVAVFAHRLYGAITSAHFMAETVP-FAKPAMI MUL_2265|M.ulcerans_Agy99 IAERLRPGGVIQREIAMRTVAVFAHRLYGAITSAHFMAETVP-FAKPAMI Mb2073c|M.bovis_AF2122/97 IAERLRPSGVIQREIAMRTVAVFAHRLYGAITSAHFMAATVP-FAKPATI Rv2047c|M.tuberculosis_H37Rv IAERLRPSGVIQREIAMRTVAVFAHRLYGAITSAHFMAATVP-FAKPATI MAV_2451|M.avium_104 IAERLRPGGLVQREIALRTVGVFAHRLYGAITSAHFMAETVP-FAKPSMI TH_4555|M.thermoresistible__bu MNARAGFQDLLGQRLYKDK---YGTVYWNVDMDEKRLRYVLPRFARPAGA MAB_2971c|M.abscessus_ATCC_199 SKARVELYVRALQDSGAPVTITYPGMVLGPPVGDQFGEAAEG-------- MSMEG_3934|M.smegmatis_MC2_155 VAPTTNPDWLPTIRRAAALVTETGGMTCHAAIVARELGVPCVVGARSATV MLBr_00955|M.leprae_Br4923 TAVIVQAMVFGNQGAYSGAGTLFSRNPITRESKLFGEWLPGGQGDDVVSG Mflv_0493|M.gilvum_PYR-GCK LSVCGRVIDELEPGPPKPFVRKLINTVRLSTFALSSAPAIRRLPQTIAAF Mvan_1818|M.vanbaalenii_PYR-1 MSICGRVVDELEAKPPRPFARKLVNTVRLTSHALSAGPAIRRLADQIAGW MMAR_3024|M.marinum_M VSNSGFFGPSMGSLPIFGEERPPAESSFVR-RQLRTVRNIGVFGVNLVGL MUL_2265|M.ulcerans_Agy99 VSNSGFFGPSMGSLPIFGEERPPAESSFVR-RQLCTVRNIGVFGVNLVGL Mb2073c|M.bovis_AF2122/97 VSNSGFFGPSMASLPIFGAQRPPSESSRAR-RWLRTLRNIGVFGVNLVGL Rv2047c|M.tuberculosis_H37Rv VSNSGFFGPSMASLPIFGAQRPPSESSRAR-RWLRTLRNIGVFGVNLVGL MAV_2451|M.avium_104 VSNSGFFGPSMASLPVFGEQRP-AETGWAR-RLLRNTRNIGVFGVNLVGL TH_4555|M.thermoresistible__bu NVVPADMQEQMFAEPLDVVRWLKAMISFSVSPIYSLSRWKKVIREDYLFN MAB_2971c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_3934|M.smegmatis_MC2_155 ALAVGSMVTVDGTRGEVTTGRLPETVRTTTTPQEPAPHITG--------- MLBr_00955|M.leprae_Br4923 LVEVQPITSLRDEQP----------------------------------- Mflv_0493|M.gilvum_PYR-GCK PPITSRDPAVVLRHLE-------AGVDIYREVTLIHVRSSSRSAVAANVL Mvan_1818|M.vanbaalenii_PYR-1 PIPSHEDARLVLQQLE-------SGVQLYCDVTLTHVRSSSRAAVAANIL MMAR_3024|M.marinum_M SAGSALDTNDFIADVDRLEQLAGGDVTTLDDRRLLSLILLARDHVVHGWV MUL_2265|M.ulcerans_Agy99 SAGSALDTNDFIADVDRLEQLAGGDVTTLDDRRLLSLILLARDHVVHGWV Mb2073c|M.bovis_AF2122/97 SAGSPRDTDAYVADVDRLERLAFDNLATHDDRRLLSLILLARDHVVHGWV Rv2047c|M.tuberculosis_H37Rv SAGSPRDTDAYVADVDRLERLAFDNLATHDDRRLLSLILLARDHVVHGWV MAV_2451|M.avium_104 SSGAARDTDDFIADVDRLERLAG-DAAELDERRLLSLIALARDQVVHGWV TH_4555|M.thermoresistible__bu EAAVAKANGLSDAELRALSDDELYRYQRDLQEYAIDFMDPLWFGAYTAMS MAB_2971c|M.abscessus_ATCC_199 ---------------------------------VRWVLLTRSVPGRSAAW MSMEG_3934|M.smegmatis_MC2_155 -------------------------EATGTKVYVNLAMPDSAEAVAAQDV MLBr_00955|M.leprae_Br4923 ---------------------------TVYDELVDTAGRLERLGSDVQEI Mflv_0493|M.gilvum_PYR-GCK ESHLVRRAAKRGASDTAGSAEAIRLMTGAG-VESALMVEELTAVVSMLRR Mvan_1818|M.vanbaalenii_PYR-1 ESTLVRQAVKNGRSEEEGQAEAARLMAGASDVESAMMLDQLQSVVRAIAA MMAR_3024|M.marinum_M LASGSFMLCAAFNVLLRAVSGRDTAPAAGPELVSARSVEAVQRLVAAARH MUL_2265|M.ulcerans_Agy99 LASGSFMLCAAFNVLLRAVSGRDTAPAAGPELVSARSVEAVQRLVDAARH Mb2073c|M.bovis_AF2122/97 LASGSFMLCAAFNVLLRGLCGRDTAPAAGPELVSARSVEAVQRLVAAARR Rv2047c|M.tuberculosis_H37Rv LASGSFMLCAAFNVLLRGLCGRDTAPAAGPELVSARSVEAVQRLVAAARR MAV_2451|M.avium_104 LASASFMLCAAFNVLLRAVCGRDTSAPAGPELVSARSVEAMQRLVVAAQR TH_4555|M.thermoresistible__bu MFFSLHAALLAKYYTGTNELLGQDLISGLPTTLQALENRAFFELTSMIRH MAB_2971c|M.abscessus_ATCC_199 LVVDVRDLAALHTALLEPSRGPRRYTAGGHRLEVGELVDLLTEAAGSAVL MSMEG_3934|M.smegmatis_MC2_155 DGVGLLRAEFMLTEALAGRHPRDLITKGEQDTLVDAMAAAVTRIGTAFAP MLBr_00955|M.leprae_Br4923 EFTTEDSKLWLLQTRVAERSAQVAVRLALQLWQEGLIDDAEALRRVTPVH . Mflv_0493|M.gilvum_PYR-GCK DGDAAARFLAAPAGEAVTRLRAAET--PSGAALRTFLDRHGHRGYRELCM Mvan_1818|M.vanbaalenii_PYR-1 DSGVATRFLAAAPDVAVVELQRADN--ASGEALRQFLLRHGHRGYRELCM MMAR_3024|M.marinum_M DEAVIR--LLSEPGDRLGKLAVAAP--HFYDAVRQELSLIGHRGPAEVEM MUL_2265|M.ulcerans_Agy99 DEAVIR--LLSEPGDRLGKLAVAAP--HFYDAVRQELSLIGHRGPAEVEM Mb2073c|M.bovis_AF2122/97 DPVVIR--LLAEPGERLDKLAVEAP--EFHSAVLAELTLIGHRGPAEVEM Rv2047c|M.tuberculosis_H37Rv DPVVIR--LLAEPGERLDKLAVEAP--EFHSAVLAELTLIGHRGPAEVEM MAV_2451|M.avium_104 DPNVAR--VLTEPGERLDKLAVDAP--EFHAAVLAELALIGHRGPAELEM TH_4555|M.thermoresistible__bu SKVLSDAFEKHQGAAFFAELENSDEGREFLEKYREFLAEHGHRGHPDRDL MAB_2971c|M.abscessus_ATCC_199 AVPVPDS-LLRAAGTVMDQIGRYVP-------WETPMTEAGMQYYTQMPA MSMEG_3934|M.smegmatis_MC2_155 RPVIYR--AMDFRTNEFRGLAGGEQ-----FEPVEHNPMIGYRGCYRYIK MLBr_00955|M.leprae_Br4923 VETVLLPVLQPENHLSATLLAKGTP---------TCPGVISGKAYTEVDE : . : Mflv_0493|M.gilvum_PYR-GCK RDPSWADDPDGLGAMMQVMLRGAAPENPAATAPSD--------------- Mvan_1818|M.vanbaalenii_PYR-1 RDPSWAQDAGGLGAMMQVMVRAASSDRQPAHSPTE--------------- MMAR_3024|M.marinum_M MSTSYADNPELLVGMVAKTLSTSS-----VPQPPQ--------------- MUL_2265|M.ulcerans_Agy99 MSTSYADNPELLVGMVAKTLSTSS-----VPQPPQ--------------- Mb2073c|M.bovis_AF2122/97 AATSYADNPELLVRMVAKTLRAVP-----APQPPT--------------- Rv2047c|M.tuberculosis_H37Rv AATSYADNPELLVRMVAKTLRAVP-----APQPPT--------------- MAV_2451|M.avium_104 LSTSYADDPELLVRMVAKAMAATA-----APPPQH--------------- TH_4555|M.thermoresistible__bu IFKRRADDPAVDYEAFKVQLQAPEATPPIELEERVRARREAAEAEVIENL MAB_2971c|M.abscessus_ATCC_199 SDDTPSE------RELGITYRDPR-------------------------- MSMEG_3934|M.smegmatis_MC2_155 EPD----------------------------------------------- MLBr_00955|M.leprae_Br4923 ALD----------------------------------------------- Mflv_0493|M.gilvum_PYR-GCK ------PAQSRTLRVLARLAQAGARGREETKSRMALMAHLLKRGYRHLGE Mvan_1818|M.vanbaalenii_PYR-1 ------APTSPAIRFLARLAQGGARGREETKSKMALMAHALKRGYRHLGE MMAR_3024|M.marinum_M ------PSIPLQAKPIAVLAARQLRDREARRDKMVRAIWVLRALLREHGR MUL_2265|M.ulcerans_Agy99 ------PSIPLQAKPIAVLAARQLRDREARRDKMVRAIWVLRALLREHGR Mb2073c|M.bovis_AF2122/97 ------PVIPLRAKPVALLAARQLRDREVRRDRMVRAIWVLRALLREYGR Rv2047c|M.tuberculosis_H37Rv ------PVIPLRAKPVALLAARQLRDREVRRDRMVRAIWVLRALLREYGR MAV_2451|M.avium_104 ------PRIPLQAKLIAALTARQLRDREARRDKVVRANWVLRALLREYGR TH_4555|M.thermoresistible__bu GRGFLGPVKQQLFKLLQHQIIDFLVLRDDWRHFIDRITYAKRKAFLEVAR MAB_2971c|M.abscessus_ATCC_199 ----------------ETLADTVVSLRAGRTTSKLWGLWPFSE------- MSMEG_3934|M.smegmatis_MC2_155 --------------LFALELSALARAREHTPNIHLMIPFVRTRWELEECL MLBr_00955|M.leprae_Br4923 ---------------AAESAEQVILVRDHTRPDDVLGMLASQGVVTEVGG * Mflv_0493|M.gilvum_PYR-GCK VLHEAGRLPDADLVFFFDRRELPLVVSGDDVTELVHRARQRRE---ALPF Mvan_1818|M.vanbaalenii_PYR-1 VLARSGRLPDADLVFFFDRSELPRVVGDDDISELVQSAVKRRE---ALAY MMAR_3024|M.marinum_M RLAEAGVLHASDDVFYLLVDELDALP-----ADVAELVARRRA---EQRR MUL_2265|M.ulcerans_Agy99 RLAEAGVLHASDDVFYLLVDEVDALP-----ADVAELVARRRA---EQRR Mb2073c|M.bovis_AF2122/97 RLTEAGVFDTPDDVFYLLVDEIDALP-----ADVSGLVARRRA---EQRR Rv2047c|M.tuberculosis_H37Rv RLTEAGVFDTPDDVFYLLVDEIDALP-----ADVSGLVARRRA---EQRR MAV_2451|M.avium_104 RLTHAGVFGSADDVFYLLVDELDALP-----ADVAAVVARRRA---EHRR TH_4555|M.thermoresistible__bu RCVERGRLEKEDDAFFLGETELFEVLNGTAKQPLVQAKIAARRPDFELFE MAB_2971c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_3934|M.smegmatis_MC2_155 ALVDASPLRRHRNLHRWVMAEVPSVVH-------------------WLPE MLBr_00955|M.leprae_Br4923 AASHAAVVSR---------------------------------------E Mflv_0493|M.gilvum_PYR-GCK QAALEFGDVSVGRPTPIVR--AAVSGDGVVAGRPAGHGSVEGVVRVARSV Mvan_1818|M.vanbaalenii_PYR-1 QDSLEFEDVSVGRPRPVVAPPVITSTADQVVGRPASRGTVEGTVRVAKTI MMAR_3024|M.marinum_M LTAVVPPTVFSGKWEPSTASAAALTAGGTLRGVGVCGGRVRGRVRIVR-P MUL_2265|M.ulcerans_Agy99 LTAVVPPTVFSGKWEPSTASAAALTAEGTLRGVGVCGGRVRGRVRIVR-P Mb2073c|M.bovis_AF2122/97 LAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIVR-P Rv2047c|M.tuberculosis_H37Rv LAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIVR-P MAV_2451|M.avium_104 LAGIAPPTVFSGSWQPTATSVPALAGGGTLRGVGVCGGRVRGRVRIVR-P TH_4555|M.thermoresistible__bu SRTFTPPMFMRGETPVDEAAPAAVAGSGAINGVGTSAGQVEGRARVLASM MAB_2971c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_3934|M.smegmatis_MC2_155 YVGMGIDGVSIGSND-LTQLMLGVDRDSETCAELFDESDAAVLDAISRII MLBr_00955|M.leprae_Br4923 LSRVAVVGCGQGTAVSLAGKQITVDGD---------KGEVRQGNLTLSAW Mflv_0493|M.gilvum_PYR-GCK VEARDLQPGEILVAPVTDVGWTPYFAVIAALVTDIGSSVSHGAVVAREYG Mvan_1818|M.vanbaalenii_PYR-1 QDARDVQRGEILVAPVTDVGWTPYFTVIAALITDIGSSVSHGAVVAREYG MMAR_3024|M.marinum_M ETIDELEPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFG MUL_2265|M.ulcerans_Agy99 ETIDELEPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFG Mb2073c|M.bovis_AF2122/97 ETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFG Rv2047c|M.tuberculosis_H37Rv ETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFG MAV_2451|M.avium_104 ETIDDLQPGEILVAEATDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFG TH_4555|M.thermoresistible__bu TEIGTLEQGDVLVCNATDPGWSPVFGVISGLIIETGGMLAHGACLSREHG MAB_2971c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_3934|M.smegmatis_MC2_155 STANRLGITSSLCGQAPSTRPEFAEHLVRMGITSVSVNPDAAGAARRAVA MLBr_00955|M.leprae_Br4923 SENETPELRELADIARRISPLRVHMTEDHTRLDDSSDTAVRLAINTGHAD Mflv_0493|M.gilvum_PYR-GCK LPCVVNTLVGTQVLRTGDRVRVDGDRGLVTVLDSP--------------- Mvan_1818|M.vanbaalenii_PYR-1 LPCVVNTLVGTQVLRTGDRVRVDGDRGVVTRLG----------------- MMAR_3024|M.marinum_M FPCVVDAQGATRFLPPGALIEVDGTTGEIQVLELAAEGDSSVTQSDPADL MUL_2265|M.ulcerans_Agy99 FPCVVDAQGATRFLPPGALIEVDGTTGEIQVLELAAEGDSSVTQSDPADL Mb2073c|M.bovis_AF2122/97 FPCVVDAQGATRFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR- Rv2047c|M.tuberculosis_H37Rv FPCVVDAQGATRFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR- MAV_2451|M.avium_104 FPCVVDVQGATKSLPPGALVEVDGATGEIRVLELASEPATGGG------- TH_4555|M.thermoresistible__bu IP-AVQIVGATQIIPDGAYVRINGTTGLVEVLEPAPAGAA---------- MAB_2971c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_3934|M.smegmatis_MC2_155 AAERRLLLDSVRHPRHAPTASPRNPL------------------------ MLBr_00955|M.leprae_Br4923 VVSATPLIVMMTTLRLQDSKDSSAKS------------------------ Mflv_0493|M.gilvum_PYR-GCK - Mvan_1818|M.vanbaalenii_PYR-1 - MMAR_3024|M.marinum_M A MUL_2265|M.ulcerans_Agy99 A Mb2073c|M.bovis_AF2122/97 - Rv2047c|M.tuberculosis_H37Rv - MAV_2451|M.avium_104 - TH_4555|M.thermoresistible__bu - MAB_2971c|M.abscessus_ATCC_199 - MSMEG_3934|M.smegmatis_MC2_155 - MLBr_00955|M.leprae_Br4923 -