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VSKVHVLVTDAAGAIGRLVTRQLIAAGHTVSGISSHPHDYLDPNVDFVCASLRNPVLLELASEADAVIHL APVEKGAPGAAGITGLAHVSNAAARAGARLLFVSQAAGSPELYQQAETLVSTGWAPSLVIRIAPPVGRQL DWMVCRTVATLMRSKVSARPMRVLHLDDLVRFLVLALDTDRNGVVDLATPDTTNVVTAWRLLGSVDPRLR PHRVQGWSQLIPEMDIAAAQEDWNFQYGWQATDAIVDTGRGLVGRRLDPAGATIGSAQLALPVEPTPRLT PADGTALDSAAPDGLEGEFDDRIDPRFPVFSAASLAEALPGPLTPMTLDVQMSGLRAAGRAMGQVLALGD VVAEEWGSRAIAVFGHRPYVGVSANLVAATQLPGWNERAVTQQALGGNTQVTELLPFGRPQLTGGPLRSA AKVLVTARSLSLLRHIRADTQAYVTAAADEHVGAEQLSTLPDASLEVRIRLLRDRIHQGWILTALWVIDT GVTAATLEHTRAGTSVSGVGVIMESGRIAAEIAALTEILRADAPLCALARDGNVDSIRALSASAAAALDA TVARLAHRGCGEAELANPSFGDDPALLLTAAAKAAAAPATPAAAPTLSQRLAASARGSRELAHDTTIRFT HDLRMTLRELASRRVTADLMDTIDDVYYLTADELVTMPADARLRIKRRRTERERLQAQHPPEVIDGNWNP AL
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_2747 | - | - | 100% (702) | hypothetical protein MMAR_2747 |
M. marinum M | MMAR_3024 | - | 1e-62 | 29.10% (763) | hypothetical protein MMAR_3024 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1899 | - | 0.0 | 79.77% (697) | hypothetical protein Mb1899 |
M. gilvum PYR-GCK | Mflv_0493 | - | 2e-11 | 25.87% (433) | pyruvate, water dikinase |
M. tuberculosis H37Rv | Rv1868 | - | 0.0 | 79.77% (697) | hypothetical protein Rv1868 |
M. leprae Br4923 | MLBr_00204 | rmlB2 | 2e-05 | 26.97% (152) | putative sugar-nucleotide dehydratase |
M. abscessus ATCC 19977 | MAB_0503 | - | 9e-05 | 22.73% (154) | UDP-glucose 4-epimerase GalE1 |
M. avium 104 | MAV_2850 | - | 0.0 | 69.15% (697) | hypothetical protein MAV_2850 |
M. smegmatis MC2 155 | - | - | - | - | - |
M. thermoresistible (build 8) | TH_4331 | - | 7e-06 | 27.43% (226) | PUTATIVE NAD-dependent epimerase/dehydratase |
M. ulcerans Agy99 | MUL_3007 | - | 0.0 | 99.14% (699) | hypothetical protein MUL_3007 |
M. vanbaalenii PYR-1 | Mvan_1926 | - | 9e-05 | 24.28% (276) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_2747|M.marinum_M -----------------------------------MSKVHVLVTDAAGAI MUL_3007|M.ulcerans_Agy99 --------------------------------------MHVLVTDAAGAI Mb1899|M.bovis_AF2122/97 --------------------------------------MQILVTDATGAV Rv1868|M.tuberculosis_H37Rv --------------------------------------MQILVTDATGAV MAV_2850|M.avium_104 --------------------------------------MHILVTDATGAL MLBr_00204|M.leprae_Br4923 ---------------------------------MYGEPVRALVTGAAGFI MAB_0503|M.abscessus_ATCC_1997 --------------------------------------MRAMVTGAAGFI Mvan_1926|M.vanbaalenii_PYR-1 --------------------------------------MKVFVTGASGFI TH_4331|M.thermoresistible__bu -----------------------------------VKNLRVLVTGATGYV Mflv_0493|M.gilvum_PYR-GCK MFDASSRIVDLADVLDDSFGGKALGLAELTRLGLPVPPGFVIADASGTSL :. : : MMAR_2747|M.marinum_M GRLVTR----------QLIAAGHTVSGISSHPHDYLDPNVDFVCASLRNP MUL_3007|M.ulcerans_Agy99 GRLVTR----------QLIAAGHTVSGISSHPHDYLDPNVDFVCASLRNP Mb1899|M.bovis_AF2122/97 GRSVTR----------QLIAAGHTVSGIAQHPHDALDPRVDYVCASLRNP Rv1868|M.tuberculosis_H37Rv GRSVTR----------QLIAAGHTVSGIAQHPHDALDPRVDYVCASLRNP MAV_2850|M.avium_104 GRLVAG----------QLIAAGHTVTGIAELPHPCLDGNVEFVCAPLRDR MLBr_00204|M.leprae_Br4923 GSTLVD----------RLLADGHTVVGLDNFATGHAAN------------ MAB_0503|M.abscessus_ATCC_1997 GSTLVD----------RLLADGHEVTGLDNLATGKVAN------------ Mvan_1926|M.vanbaalenii_PYR-1 GSAVTA----------ELLGHGHHVLGLAR-------------------- TH_4331|M.thermoresistible__bu GSRLVT----------SLLAAGHDVVAASRNPRRLTDFG----------- Mflv_0493|M.gilvum_PYR-GCK GDAVTERFSRMRAAGQTPVAVRSSAAGEDGAEHSFAGQYDTVLGVGSVDE * :. :. . . MMAR_2747|M.marinum_M VLLELASEADAVIHLAPVEKGAPGAAGITGLAHVSNAAARAGARLLFVSQ MUL_3007|M.ulcerans_Agy99 VLLELASEADAVIHLAPVEKGAPGAAGITGLAHVSNAAARAGARLLFVSQ Mb1899|M.bovis_AF2122/97 VLQELAGEADAVIHLAPVDTSAPGGVGITGLAHVANAAARAGARLLFVSQ Rv1868|M.tuberculosis_H37Rv VLQELAGEADAVIHLAPVDTSAPGGVGITGLAHVANAAARAGARLLFVSQ MAV_2850|M.avium_104 VLRELTDEADAVIHLAPIDPTAPGNAAMDGLARVTDAAARAGSRLLFVSQ MLBr_00204|M.leprae_Br4923 -----------------------------------LEHLASTPALAFVEA MAB_0503|M.abscessus_ATCC_1997 -----------------------------------LEAAEANAKFTFVKD Mvan_1926|M.vanbaalenii_PYR-1 -------------------------------------SDAAAQRITATGA TH_4331|M.thermoresistible__bu -----------------------------------WYDRVTPVALDAHDE Mflv_0493|M.gilvum_PYR-GCK LTAAVEKCVRSAGSERAAAYQDGGAAARMHLVVQQMVDARAAGVVFTADP : . MMAR_2747|M.marinum_M AAGSPELYQQAETLVSTGWAPS----LVIRIAPPVGRQLDWMVCRTVATL MUL_3007|M.ulcerans_Agy99 AAGSPELYQQAETLVSTGWAPS----SVIRIAPPVGRQLDWTVCRTVTTL Mb1899|M.bovis_AF2122/97 AAGRPELYRQAETLVSTGWAPS----LVIRIAPPVGRQLDWMVCRTVATL Rv1868|M.tuberculosis_H37Rv AAGRPELYRQAETLVSTGWAPS----LVIRIAPPVGRQLDWMVCRTVATL MAV_2850|M.avium_104 AAGRPELYRPAEDLVASSWGPS----VVVRIAPPVGRQLDWMVCRTVATV MLBr_00204|M.leprae_Br4923 DIVTADLQ-----TILDEHRPE----VVFHLAAQID-------------- MAB_0503|M.abscessus_ATCC_1997 DIVEADLD-----AVVAEYSPE----VIFHLAAQID-------------- Mvan_1926|M.vanbaalenii_PYR-1 EAVRGDLD-DLDALEAGASAAD----AVIHLAFQHD-------------- TH_4331|M.thermoresistible__bu DSVSAALAR----AGSGARPVD----VIYYLVHGIG-------------- Mflv_0493|M.gilvum_PYR-GCK TSGRRDLLVIDAVRGLGESLVDGSTASDHFVLTHAGDTVTTEASSQPALA * . : . MMAR_2747|M.marinum_M MRSKVSARPMRVLHLDDLVRFLVLALDTDRNGVVDLATPDTTNVVTAWRL MUL_3007|M.ulcerans_Agy99 MRSKVSARPMRVLHLDDLVRFLVLALDTDRNGVVDLATPDTTNVVTAWRL Mb1899|M.bovis_AF2122/97 LRSKVSARPIRVLHLDDLVRFLVLALNTDRNGVVDLATPDTTNVVTAWRL Rv1868|M.tuberculosis_H37Rv LRSKVSARPIRVLHLDDLVRFLVLALNTDRNGVVDLATPDTTNVVTAWRL MAV_2850|M.avium_104 LRTKVSAQPMRVLHLDDLMRFLVTALDTDRTGVVDLASPDTVNLVTAWRM MLBr_00204|M.leprae_Br4923 ----------------------------VRHSVVDPQFDASVNVIGTVRL MAB_0503|M.abscessus_ATCC_1997 ----------------------------VRHSVADPQFDSSVNVVGTVRL Mvan_1926|M.vanbaalenii_PYR-1 ------------------------------FTAYDTAARVDRQAIETLGE TH_4331|M.thermoresistible__bu -----------------------------QDGFREADNRAAANVAAAAKY Mflv_0493|M.gilvum_PYR-GCK DDEIDRIRTGALLAAAHWGRPLDLEWAIDRDGLLWWLQARPITTLPGDPN MMAR_2747|M.marinum_M LGSVDPRLRPHRVQGWSQLIPEMDIAAAQEDWNFQYGWQATDAIVDTGRG MUL_3007|M.ulcerans_Agy99 LGSIDPRLRPHRVQGWSQLIPEMDIAAAQEDWNFQYGWQATDAIVDTGRG Mb1899|M.bovis_AF2122/97 LRSVDPHLRTRRVRSWEQLIPEVDIAAVQEDWNFEFGWQATEAIVDTGRG Rv1868|M.tuberculosis_H37Rv LRSVDPHLRTRRVRSWEQLIPEVDIAAVQEDWNFEFGWQATEAIVDTGRG MAV_2850|M.avium_104 LRATDPRSRLHRVRSWSQLIPDLNVAAAQEDWLFEFGWHALDAVADTARG MLBr_00204|M.leprae_Br4923 AEAAR--------------------------------HTGVRKIVHTS-- MAB_0503|M.abscessus_ATCC_1997 AEAAR--------------------------------KAGVRKIVHTS-- Mvan_1926|M.vanbaalenii_PYR-1 ALAGSDR-----------------------------ALVVASGMAGLGRG TH_4331|M.thermoresistible__bu AGVRR--------------------------------IVYLGGFVPDGEA Mflv_0493|M.gilvum_PYR-GCK EMDTPVTGPTHVYTRCNIGEMMPGAFCPLTASVSGHAIDYAMQMVQVAGG .. . MMAR_2747|M.marinum_M LVGRRLDPAGAT-IGSAQLALPVEPTPRLTPADGTALDSAAPDGLEGEFD MUL_3007|M.ulcerans_Agy99 LVGRRLDPAGAT-IGSAQLALPVEPTPRLTPADGTALDSAAPDGLEGEFD Mb1899|M.bovis_AF2122/97 LVGRRLHPAGAT-NGSGQLALPVEAPPRSVPSHGEPLGSAAPEGLEGEFD Rv1868|M.tuberculosis_H37Rv LVGRRLHPAGAT-NGSGQLALPVEAPPRSVPSHGEPLGSAAPEGLEGEFD MAV_2850|M.avium_104 LVGRRLDTAGAI-NHGAQLALPVEVLP---QRAGNGAHSAAPEGVEGEFD MLBr_00204|M.leprae_Br4923 -------------------------------------------------- MAB_0503|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_1926|M.vanbaalenii_PYR-1 R------------------------------------------------- TH_4331|M.thermoresistible__bu LS------------------------------------------------ Mflv_0493|M.gilvum_PYR-GCK VQERYEDRARQVGYFFGHMFLNMTEGTALSSGILGNSLEQFSLSVCGRVI MMAR_2747|M.marinum_M DRIDPRFPVFSAASLAEALPGPLTPMTLDVQMSGLRAAGRAMGQVLALGD MUL_3007|M.ulcerans_Agy99 DRIDPRFPVFSAASLAEALPGPLTPMTLDVQMSGLRAAGRAMGQVLALGD Mb1899|M.bovis_AF2122/97 DRIDERFPVFSSASLAEALPGPLTPMTLDVQLSGLRAAGRAMGRVLALGG Rv1868|M.tuberculosis_H37Rv DRIDERFPVFSSASLAEALPGPLTPMTLDVQLSGLRAAGRAMGRVLALGG MAV_2850|M.avium_104 DRIDPRFPVFSATALTDALPGPLTPITLDVQLSGLRTASRVLGRVLALGG MLBr_00204|M.leprae_Br4923 ----------SGGSIYGTPSQYPTPETVPTDPTSPYAAGKVAGEIYLN-- MAB_0503|M.abscessus_ATCC_1997 ----------SGGSIYGTPKQIPTSETVPTDPHSPYAAGKVAGEIYLN-- Mvan_1926|M.vanbaalenii_PYR-1 -------ILTEDQAAPPDAPRESEPAVFAFTDRGVRAAAVRLAPTVHG-- TH_4331|M.thermoresistible__bu ------EHLSSRAEVAHALHVDGGADVVWLGAAMIIGAGSTSFEMLRYVG Mflv_0493|M.gilvum_PYR-GCK DELEPGPPKPFVRKLINTVRLSTFALSSAPAIRRLPQTIAAFPPITSRDP . : MMAR_2747|M.marinum_M VVAEEWGSRAIAVFGHRPYVGVSANLVAATQLPGWNERAVTQQALGGNTQ MUL_3007|M.ulcerans_Agy99 VVAEEWGSRAIAVFGHRPYVGVSANLVAATQLPGWNERAVTQQALGGNTQ Mb1899|M.bovis_AF2122/97 VVADEWERRAIAVFGHRPYIGVSANIVAAAQLPGWDAQAVARRALGEQPQ Rv1868|M.tuberculosis_H37Rv VVADEWERRAIAVFGHRPYIGVSANIVAAAQLPGWDAQAVARRALGEQPQ MAV_2850|M.avium_104 AVGEEWDSRAIAVFGHRPYVGVSVNMVAATQLPGWDQDAVARDALVGRPQ MLBr_00204|M.leprae_Br4923 --------------TFRHLCGLDCSHIAPANVYG---------------- MAB_0503|M.abscessus_ATCC_1997 --------------TFRHLYGLECSHIAPANVYG---------------- Mvan_1926|M.vanbaalenii_PYR-1 ----------------EGDHGFVPTLISIARATG---------------- TH_4331|M.thermoresistible__bu -----------DRFLVLPLPEWSANPIDPISISDVLYYLVAAADADSVPA Mflv_0493|M.gilvum_PYR-GCK AVVLRHLEAGVDIYREVTLIHVRSSSRSAVAANVLESHLVRRAAKRGASD . MMAR_2747|M.marinum_M VTELLPFGRPQLTGGPLRSAAKVLVTARSLSLLRHIRADTQAYVTAAADE MUL_3007|M.ulcerans_Agy99 VTGLLPFGRPQLTGGPLRSAAKVLVTARSLSLLRHIRADTQAYVTAAADE Mb1899|M.bovis_AF2122/97 VTELLPFGRPQLAGGPLGSVAKVVVTARSLALLRHLRSDTHHYVAAADAE Rv1868|M.tuberculosis_H37Rv VTELLPFGRPQLAGGPLGSVAKVVVTARSLALLRHLRSDTHHYVAAADAE MAV_2850|M.avium_104 VGDPLPFGEPALAGGALGSIAKAVAAGRSVALLRHLRANTRDYCAAAVAE MLBr_00204|M.leprae_Br4923 -----PRQDPYGEAGVVAIFVQALLSDRPTKVFG---------------- MAB_0503|M.abscessus_ATCC_1997 -----PRQDPHGEAGVVAIFAQALLSGRSTKVFG---------------- Mvan_1926|M.vanbaalenii_PYR-1 ---------VSTYPGDGSNRWPAVHRLDAAALFR---------------- TH_4331|M.thermoresistible__bu GAYDICGPDTTTYGDLLHTYARIAGKWRADLPIRG--------------- Mflv_0493|M.gilvum_PYR-GCK TAGSAEAIRLMTGAGVESALMVEELTAVVSMLRRDGDAAARFLAAPAGEA . MMAR_2747|M.marinum_M HVGAEQLSTLPDASLEVRIRLLRDRIHQGWILTALWVIDTGVTAATLEHT MUL_3007|M.ulcerans_Agy99 HVGAEQLSTLPDASLEVRIRLLRDRIHQGWILTALWVIDTGVTAATLEHT Mb1899|M.bovis_AF2122/97 HLAAGQLASLPDAGLEVRIRLLRDRIHQGWILTVLWVIDTGVTAATLEHT Rv1868|M.tuberculosis_H37Rv HLAAGQLASLPDAGLEVRIRLLRDRIHQGWILTVLWVIDTGVTAATLEHT MAV_2850|M.avium_104 QVDAAQLALLPQAALEVRLRLLRDRIHQGWILNALWLLDTGITAAALVRS MLBr_00204|M.leprae_Br4923 ------------DGTHTRDYVFVDDVVDAFIK------------------ MAB_0503|M.abscessus_ATCC_1997 ------------DGGNTRDYVFVDDVVEAFVR------------------ Mvan_1926|M.vanbaalenii_PYR-1 -----------IAAEDAPAGTLLHAVAD---------------------- TH_4331|M.thermoresistible__bu -VDTAVVSRLSAAMLPVPGGLAADLVESLDYP------------------ Mflv_0493|M.gilvum_PYR-GCK VTRLRAAETPSGAALRTFLDRHGHRGYRELCMRDPSWADDPDGLGAMMQV . . MMAR_2747|M.marinum_M RAGTSVSGVGVIMESGRIAAEIAALTEILRADA----------------- MUL_3007|M.ulcerans_Agy99 RAGTSVSGVGVIMESGRIAAETAALTEILRADA----------------- Mb1899|M.bovis_AF2122/97 RAGSAVSGGGMIMESGRIGAEIAPLAAVLRADP----------------- Rv1868|M.tuberculosis_H37Rv RAGSAVSGGGMIMESGRIGAEIAPLAAVLRADP----------------- MAV_2850|M.avium_104 QAGQSVPGLGMITESGLVAAETAELAAMLAADP----------------- MLBr_00204|M.leprae_Br4923 --ASGDAGGGQRFNIG---------------------------------- MAB_0503|M.abscessus_ATCC_1997 --ASGPDGGGQRFNVG---------------------------------- Mvan_1926|M.vanbaalenii_PYR-1 ---EGIPVRQIAEAIG---------------------------------- TH_4331|M.thermoresistible__bu MVASADRLHGLVPDPP---------------------------------- Mflv_0493|M.gilvum_PYR-GCK MLRGAAPENPAATAPSDPAQSRTLRVLARLAQAGARGREETKSRMALMAH . MMAR_2747|M.marinum_M ---PLCALARDGNVDSIRALSASAAAALDATVARLAHRGCGEAELANPSF MUL_3007|M.ulcerans_Agy99 ---PLCALARDGNVDSIRALSASAAAALDATVARLAHRGCGEAELANPSF Mb1899|M.bovis_AF2122/97 ---PLCALANDGNLASIRALSAPAAAAVDAVIARIGHRGLGEAELANLTF Rv1868|M.tuberculosis_H37Rv ---PLCALANDGNLASIRALSAPAAAAVDAVIARIGHRGLGEAELANLTF MAV_2850|M.avium_104 ---PLCALAADGNLASIRALAPKTAAAVDAAVARIGHRGPGDAELASQTF MLBr_00204|M.leprae_Br4923 ----------TGIETSDRQLHTAVSAAVG---------GPDDPEFHPPRL MAB_0503|M.abscessus_ATCC_1997 ----------TGVETSDRQLHSLVAAAAG---------APDDPEFHPPRL Mvan_1926|M.vanbaalenii_PYR-1 ----------HGLDVSVEATTAQAS--------------IDRAGFIGAVF TH_4331|M.thermoresistible__bu ----------GGLVGVDDAIARALSSREAR---------PVDDLLDPHHL Mflv_0493|M.gilvum_PYR-GCK LLKRGYRHLGEVLHEAGRLPDADLVFFFDRRELPLVVSGDDVTELVHRAR : MMAR_2747|M.marinum_M GDDPALLLTAAAKAAAAPATPAAAPTLSQRLAASARGSRELAHDTTIRFT MUL_3007|M.ulcerans_Agy99 GDDPALLLTAAAKAAAAPATPAAAPTLSQRLAASARGSRELAHDTTIRFT Mb1899|M.bovis_AF2122/97 ADDPALLLKTAAEIAARPAGPAHPATLIQRLAAGTRSARELAHDTTIRFT Rv1868|M.tuberculosis_H37Rv ADDPALLLKTAAEIAARPAGPAHPATLIQRLAAGTRSARELAHDTTIRFT MAV_2850|M.avium_104 ADDPAMLLSAAAAAAAAPAEPAAPATLAERLAANARGSKELAHDATMRFT MLBr_00204|M.leprae_Br4923 GD------------------------LKRSCLDIGLATTVLGWSPQVQLD MAB_0503|M.abscessus_ATCC_1997 GD------------------------LRQSCLDVGLAKRVLGWEPRVPLA Mvan_1926|M.vanbaalenii_PYR-1 AMDLP--------------------------ASSALTRTQFGWQPTHPGL TH_4331|M.thermoresistible__bu ATTDP-----------------------QWAGGDALRIQRLARSVTPSVI Mflv_0493|M.gilvum_PYR-GCK QRREALPFQAALEFGDVSVGRPTPIVRAAVSGDGVVAGRPAGHGSVEGVV . MMAR_2747|M.marinum_M HDLRMTLRELASRRVTADLMDTIDDVYYLTADELVTMPADARLRIKRRRT MUL_3007|M.ulcerans_Agy99 HDLRMTLRELASRRVTADLMDTIDDVYYLTADELVTMPADARLRIKRRRT Mb1899|M.bovis_AF2122/97 HELRMTLRELGSRRVAADVIDVVDDVFYLTCDELITTPADARLRIKRRRA Rv1868|M.tuberculosis_H37Rv HELRMTLRELGSRRVAADVIDVVDDVFYLTCDELITTPADARLRIKRRRA MAV_2850|M.avium_104 HELRMTLRALGSLRVEADLIDAVDDVYYLTCNELVTMPGDARLRIKRRRT MLBr_00204|M.leprae_Br4923 DGVRRTVEYFRAAQRS---------------------------------- MAB_0503|M.abscessus_ATCC_1997 DGIRRTVDFFRS-------------------------------------- Mvan_1926|M.vanbaalenii_PYR-1 LADLSQAHYFATPEA----------------------------------- TH_4331|M.thermoresistible__bu HPALGMIDVVPGP-VAGAVRTGLDTVLGLAPRVLP--------------- Mflv_0493|M.gilvum_PYR-GCK RVARSVVEARDLQPGEILVAPVTDVGWTPYFAVIAALVTDIGSSVSHGAV MMAR_2747|M.marinum_M ERERLQAQHPPEVIDGNWNPAL------------------- MUL_3007|M.ulcerans_Agy99 ERERLQAQHPPEVIDGNWNPAL------------------- Mb1899|M.bovis_AF2122/97 ERERLQAQRPPDVIDHAWVPVE------------------- Rv1868|M.tuberculosis_H37Rv ERERLQAQRPPDVIDHAWVPVE------------------- MAV_2850|M.avium_104 ERERLQVQCPPEVIDGRWTPPQHCAEGSPAQRPAG------ MLBr_00204|M.leprae_Br4923 ----------------------------------------- MAB_0503|M.abscessus_ATCC_1997 ----------------------------------------- Mvan_1926|M.vanbaalenii_PYR-1 ----------------------------------------- TH_4331|M.thermoresistible__bu ----------------------------------------- Mflv_0493|M.gilvum_PYR-GCK VAREYGLPCVVNTLVGTQVLRTGDRVRVDGDRGLVTVLDSP