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MAGLDSGEGQVITHVSDTARWTALYRATESARPDALFSDPLANRLAGEHGRAIVATVPRTTRNGWWLVAR TKIIDDAIARAIANGCDRVLNLAAGLDTRPYRLDLPAELTWIEADLPLLLAEKTQLLSGETPRCQLTRSA VDLADPAARDAFFTEALAGAAKALVLTEGLLMYLDEPDVIALSEAIRQPQVGWWMLDLAGPALKKMMNKK MAGMLQNAPFKFAPDNGLAFFEALGWHVAEAESLFTAAQRFRRLPISMRSLGWLPQPNPRHPGRRPWSAV TLLTQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2904 | - | - | 100% (285) | O-methyltransferase |
| M. marinum M | MMAR_0357 | - | 1e-14 | 33.51% (185) | O-methyltransferase |
| M. marinum M | MMAR_0539 | - | 8e-14 | 34.81% (181) | O-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0289 | - | 4e-15 | 36.46% (181) | hypothetical protein Mb0289 |
| M. gilvum PYR-GCK | Mflv_2136 | - | 3e-12 | 28.97% (214) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv0281 | - | 4e-15 | 36.46% (181) | hypothetical protein Rv0281 |
| M. leprae Br4923 | MLBr_01972 | - | 9e-19 | 63.24% (68) | hypothetical protein MLBr_01972 |
| M. abscessus ATCC 19977 | MAB_3886c | - | 1e-15 | 34.18% (196) | hypothetical protein MAB_3886c |
| M. avium 104 | MAV_2762 | - | 1e-128 | 78.14% (279) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_0607 | - | 6e-25 | 37.07% (232) | methyltransferase, putative, family protein |
| M. thermoresistible (build 8) | TH_0460 | omt | 9e-14 | 31.25% (192) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_4762 | - | 7e-15 | 33.51% (185) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5836 | - | 1e-105 | 66.91% (275) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0289|M.bovis_AF2122/97 -MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAFCR--A
Rv0281|M.tuberculosis_H37Rv -MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAFCR--A
MUL_4762|M.ulcerans_Agy99 -MRTHDDTWDIRTSVGATAVMVAAARAVETSKPEPLIRDPYARMLVTNAN
MAB_3886c|M.abscessus_ATCC_199 MARRDGDSWEITESVGTTALGVASARDAETRSPNPLISDPYAGHFLAAAG
Mflv_2136|M.gilvum_PYR-GCK -MSPTDKHSADLTGVSETALMTLLVRATEARRPDSLIDDPMAVKLVD---
TH_0460|M.thermoresistible__bu -VSSGPLAKPELTGVSETALLTLLVRATEARRPDGIIDDPMAVRLVD---
MMAR_2904|M.marinum_M MAGLDSGEGQVITHVSDTARWTALYRATESARPDALFSDPLANRLAGE--
MAV_2762|M.avium_104 ----MSGPGHTITHVSDTARWTALHRATESARPDAIFCDPLAERLAGD--
Mvan_5836|M.vanbaalenii_PYR-1 ----MEEPATPVSNVSDTARWVAVYRAIESARADAVFDDPFADRLAGE--
MLBr_01972|M.leprae_Br4923 --------------------------------------------------
MSMEG_0607|M.smegmatis_MC2_155 --MGDTPNPDAGRAVADTGLLVAAIRAAESRREDRLFEDPFAEKLAGE--
Mb0289|M.bovis_AF2122/97 VGGSWADVLD----GKLPDHKLKSTDFGEHFVNFQGARTKYFDEYFRRAA
Rv0281|M.tuberculosis_H37Rv VGGSWADVLD----GKLPDHKLKSTDFGEHFVNFQGARTKYFDEYFRRAA
MUL_4762|M.ulcerans_Agy99 AGVIWEAMLDQEMVAKVEAIDAETAATVEHMRSYQAVRTNFFDTYFADAV
MAB_3886c|M.abscessus_ATCC_199 DGAWNAYRFDGEPPAALVEAEPRLVERIDAMRSYVACRTKFFDDFFGDAS
Mflv_2136|M.gilvum_PYR-GCK ------------------SLDFDRAKFGFVRRQDMAVRALVFDKWTRRYL
TH_0460|M.thermoresistible__bu ------------------SIDFDFAKFGPSRRQDMALRAKAFDTATRRYL
MMAR_2904|M.marinum_M --------------HGRAIVATVPRTTRNG--WWLVARTKIIDDAIARAI
MAV_2762|M.avium_104 --------------HGRAIVDHVPRTTRNG--WWLVARTKIIDDAIAEAI
Mvan_5836|M.vanbaalenii_PYR-1 --------------RGREIVATVPRMMRSG--WWMVARTKTIDDILMDAI
MLBr_01972|M.leprae_Br4923 --------------------------------------------------
MSMEG_0607|M.smegmatis_MC2_155 --------------TGRRMLEEALATTGDKSTLQIVVRTKFWDEALLRAT
Mb0289|M.bovis_AF2122/97 AAG-ARQVVILAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLASHG
Rv0281|M.tuberculosis_H37Rv AAG-ARQVVILAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLASHG
MUL_4762|M.ulcerans_Agy99 AAG-IRQVVILASGLDSRAYRLDWPAGTTVYEIDQPQVLAYKSATLAENG
MAB_3886c|M.abscessus_ATCC_199 TSG-IRQAVILASGLDARAWRLDWPRDAVLFELDLPRVLAFKAETLDKQG
Mflv_2136|M.gilvum_PYR-GCK VDHPRATVVALAEGLQTSFYRLDSGPESVGHDFR-WLTVDLPPMIDLRTK
TH_0460|M.thermoresistible__bu RAHPKATVVALAEGLQTSFFRLN--AADVGDEFR-WVTVDLAPVIELRRQ
MMAR_2904|M.marinum_M ANG-CDRVLNLAAGLDTRPYRLDLPAELTWIEADLPLLLAEKTQLLSGET
MAV_2762|M.avium_104 AQG-CDRVLNLAAGLDTRPYRLNLPPDLTWVEADLPALLAEKTQVLADEV
Mvan_5836|M.vanbaalenii_PYR-1 GAG-CDRVLNLAAGLDTRPYRLPLSAEFSWVEADLPELIAEKEQLLAGES
MLBr_01972|M.leprae_Br4923 -------------------------------------------------M
MSMEG_0607|M.smegmatis_MC2_155 TH--VDQVVLLAAGMDARAFRLAWPAGTVVYELDQPEVIAAKSGLLADAS
Mb0289|M.bovis_AF2122/97 AQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLLIYLPATAQE
Rv0281|M.tuberculosis_H37Rv AQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLLIYLPATAQE
MUL_4762|M.ulcerans_Agy99 VTPAAERREVAIDLRQDWPSALRAAGFDPSARTAWLAEGLLMYLPAEAQD
MAB_3886c|M.abscessus_ATCC_199 ATPRIRHVPVAVDLRDDWPAALRAGGFDVGRPAAWIAEGLLPYLPPAAQD
Mflv_2136|M.gilvum_PYR-GCK LLPPSDRVRTLAQSALDFSWMDQ---VDTSEGVFITAEGLLMYLQPAEAM
TH_0460|M.thermoresistible__bu LLPADDRVTMLAQSALDYSWMDR---IDTSEGVFITAEGLLMYLQPDEAM
MMAR_2904|M.marinum_M PRCQLTRSAVDLADPAARDAFFTEALAGAAKALVL-TEGLLMYLDEPDVI
MAV_2762|M.avium_104 PRCRLTRTAVDLADGVARDAFLNEALDGATKALVL-TEGLLMYLDDSDVS
Mvan_5836|M.vanbaalenii_PYR-1 PRCRLTRHPVDLSDPVARDRFLDEALSGATKALVL-TEGLLMYLDPSDVD
MLBr_01972|M.leprae_Br4923 PSRNRDANVVDLTDSHSREAFFNEALGGATKVLVMITEGLVMYLDDRDVI
MSMEG_0607|M.smegmatis_MC2_155 PRCRWTALGVDLTR--DWTTALRSTTFDPARPAVWLAEGLLQYLDETAVH
. :***: **
Mb0289|M.bovis_AF2122/97 RLFTGIDALAGRRSHVAVEDGAPMGPD-EYAAKVEE-----ERAAIAEGA
Rv0281|M.tuberculosis_H37Rv RLFTGIDALAGRRSHVAVEDGAPMGPD-EYAAKVEE-----ERAAIAEGA
MUL_4762|M.ulcerans_Agy99 RLFTQIGELSCAGSRIAAET-AGNHAD-ERREQMRER---FRKVAQTLGL
MAB_3886c|M.abscessus_ATCC_199 LLFERIDTLSAPGSRIAVENFGEDFFNPETLARQRERGQAFRRVAEEMQG
Mflv_2136|M.gilvum_PYR-GCK SLITECAARFPGGQMIFDLPPSAFAFLVGRGVRASLR----YRVPPMPFS
TH_0460|M.thermoresistible__bu GLIRECARRFPGGQMMFDLPPSFFAWLTRRGFRTSLR----YKVPPMPFT
MMAR_2904|M.marinum_M ALSEAIRQPQVGWWMLDLAGPALKKMMNKKMAGMLQ-----NAPFKFAPD
MAV_2762|M.avium_104 ALSAALQRPEVRWWMLDFAGPGLKKMMNKKMAGMLA-----NAPFKFAPD
Mvan_5836|M.vanbaalenii_PYR-1 DLSRALVRSEVAWWMLDLAGPGLKKWMNDNTGGLLR-----NAPFKFAPA
MLBr_01972|M.leprae_Br4923 LLSEVITRSEVTWWVLDLAGPGLKK-------------------------
MSMEG_0607|M.smegmatis_MC2_155 TLFDRVDAMSAPGSVLLYDVVGKTLLDAAMLAAVRESMARSGAPWRFGTD
* : .
Mb0289|M.bovis_AF2122/97 EEHP-FFQLVYNER-CAPAAEWFGERGWTAVATLLNDYLEAVGRPVPGPE
Rv0281|M.tuberculosis_H37Rv EEHP-FFQLVYNER-CAPAAEWFGERGWTAVATLLNDYLEAVGRPVPGPE
MUL_4762|M.ulcerans_Agy99 EQTIDVHELIYHDPDRAPLGQWLNEHGWRANAQNACDEMHRVGRWVEG-V
MAB_3886c|M.abscessus_ATCC_199 QDIPDVADLWYLEE-RTDAGEFLAGRGWRVTSETAVALLGRHGRDIPADL
Mflv_2136|M.gilvum_PYR-GCK LTIAEAADLVNTVPGVRAVHDLPAEHARGRLINALLWTAQRV--PLLDPI
TH_0460|M.thermoresistible__bu LSPEQAADLVNTVPGVQAVHDVPIPRGRGVLVNTLIWAAQRT--PLFDNV
MMAR_2904|M.marinum_M NGLAFFEALGWHVAEAESLFTAAQRFRRLPISMRSLGWLPQPNPRHP-GR
MAV_2762|M.avium_104 NGLAYFENLGWRTVQVEALYSAARRLRRLPLVMRPLGWLPQPDPRRP-GR
Mvan_5836|M.vanbaalenii_PYR-1 NGVGYFEQLGWRTREVESVFVVARRLRRLPWLLRLVAWLPQPDPHRPPAD
MLBr_01972|M.leprae_Br4923 --------------------------------------------------
MSMEG_0607|M.smegmatis_MC2_155 APGELSTRLGWS-ANVTDIAEPGNAYGRWFTPAVPLDVPGVPRGYFVEAT
Mb0289|M.bovis_AF2122/97 SEAGPMFARNTLVSAARV-
Rv0281|M.tuberculosis_H37Rv SEAGPMFARNTLVSAARV-
MUL_4762|M.ulcerans_Agy99 PMADDKQAYSDFVTAERL-
MAB_3886c|M.abscessus_ATCC_199 PDATPN---SAFLFAQKAD
Mflv_2136|M.gilvum_PYR-GCK RPMFTLLEFG---------
TH_0460|M.thermoresistible__bu RGTYTLLEFGPPNSAST--
MMAR_2904|M.marinum_M RPWSAVTLLTQ--------
MAV_2762|M.avium_104 RAWSAAALLTH--------
Mvan_5836|M.vanbaalenii_PYR-1 RPWSAVVRLTR--------
MLBr_01972|M.leprae_Br4923 -------------------
MSMEG_0607|M.smegmatis_MC2_155 KPG----------------