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SGPGHTITHVSDTARWTALHRATESARPDAIFCDPLAERLAGDHGRAIVDHVPRTTRNGWWLVARTKIID DAIAEAIAQGCDRVLNLAAGLDTRPYRLNLPPDLTWVEADLPALLAEKTQVLADEVPRCRLTRTAVDLAD GVARDAFLNEALDGATKALVLTEGLLMYLDDSDVSALSAALQRPEVRWWMLDFAGPGLKKMMNKKMAGML ANAPFKFAPDNGLAYFENLGWRTVQVEALYSAARRLRRLPLVMRPLGWLPQPDPRRPGRRAWSAAALLTH *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2762 | - | - | 100% (281) | methyltransferase, putative, family protein |
| M. avium 104 | MAV_0219 | - | 1e-27 | 37.99% (229) | methyltransferase, putative, family protein |
| M. avium 104 | MAV_4873 | - | 9e-16 | 36.31% (179) | methyltransferase, putative, family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0289 | - | 2e-16 | 36.36% (176) | hypothetical protein Mb0289 |
| M. gilvum PYR-GCK | Mflv_2136 | - | 6e-12 | 31.32% (182) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv0281 | - | 2e-16 | 36.36% (176) | hypothetical protein Rv0281 |
| M. leprae Br4923 | MLBr_01972 | - | 3e-19 | 66.67% (66) | hypothetical protein MLBr_01972 |
| M. abscessus ATCC 19977 | MAB_4607c | - | 2e-13 | 32.32% (198) | hypothetical protein MAB_4607c |
| M. marinum M | MMAR_2904 | - | 1e-128 | 78.14% (279) | O-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_0607 | - | 2e-25 | 35.62% (233) | methyltransferase, putative, family protein |
| M. thermoresistible (build 8) | TH_4502 | - | 5e-12 | 32.32% (198) | PUTATIVE methyltransferase |
| M. ulcerans Agy99 | MUL_4762 | - | 1e-13 | 31.87% (182) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5836 | - | 1e-106 | 67.26% (281) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2762|M.avium_104 ------MSGPGHTITHVSDTARWTALHRATESARPDAIFCDPLAERLAGD
MMAR_2904|M.marinum_M --MAGLDSGEGQVITHVSDTARWTALYRATESARPDALFSDPLANRLAGE
MLBr_01972|M.leprae_Br4923 --------------------------------------------------
Mvan_5836|M.vanbaalenii_PYR-1 ------MEEPATPVSNVSDTARWVAVYRAIESARADAVFDDPFADRLAGE
Mb0289|M.bovis_AF2122/97 ---MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAFCRA
Rv0281|M.tuberculosis_H37Rv ---MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAFCRA
TH_4502|M.thermoresistible__bu MSSLRTDDDTWDIATSVGSTAVMVAASRAAETEREDALIRDPYAKVLVAG
MUL_4762|M.ulcerans_Agy99 ---MRTHDDTWDIRTSVGATAVMVAAARAVETSKPEPLIRDPYARMLVTN
MAB_4607c|M.abscessus_ATCC_199 ---MRVDGDTWDITSSVGATALGVAAARATETLRADALIRDPFAQILVDA
MSMEG_0607|M.smegmatis_MC2_155 ----MGDTPNPDAGRAVADTGLLVAAIRAAESRREDRLFEDPFAEKLAGE
Mflv_2136|M.gilvum_PYR-GCK ---MSPTDKHSADLTGVSETALMTLLVRATEARRPDSLIDDPMAVKLVDS
MAV_2762|M.avium_104 HGRA------------------IVDHVPRTTRNGWWLVARTKIIDDAIAE
MMAR_2904|M.marinum_M HGRA------------------IVATVPRTTRNGWWLVARTKIIDDAIAR
MLBr_01972|M.leprae_Br4923 --------------------------MPSRNRD-----------------
Mvan_5836|M.vanbaalenii_PYR-1 RGRE------------------IVATVPRMMRSGWWMVARTKTIDDILMD
Mb0289|M.bovis_AF2122/97 VGGS--WADVLDGK----LPDHKLKSTDFGEHFVNFQGARTKYFDEYFRR
Rv0281|M.tuberculosis_H37Rv VGGS--WADVLDGK----LPDHKLKSTDFGEHFVNFQGARTKYFDEYFRR
TH_4502|M.thermoresistible__bu AGTG-VWELILDDDFTAKIEAADPETAAIFDHMGNYQAVRTHFFDTYFAR
MUL_4762|M.ulcerans_Agy99 ANAGVIWEAMLDQEMVAKVEAIDAETAATVEHMRSYQAVRTNFFDTYFAD
MAB_4607c|M.abscessus_ATCC_199 TGKATGWERLVAGD----IDWPDPEAGRIYDRMVDYQATRTHFFDEYFLA
MSMEG_0607|M.smegmatis_MC2_155 TGRR----------------MLEEALATTGDKSTLQIVVRTKFWDEALLR
Mflv_2136|M.gilvum_PYR-GCK ---------------------LDFDRAKFGFVRRQDMAVRALVFDKWTRR
MAV_2762|M.avium_104 AIAQG-CDRVLNLAAGLDTRPYRLNLPPDLT-----WVEADLPALLAEKT
MMAR_2904|M.marinum_M AIANG-CDRVLNLAAGLDTRPYRLDLPAELT-----WIEADLPLLLAEKT
MLBr_01972|M.leprae_Br4923 --AN----------------------------------------------
Mvan_5836|M.vanbaalenii_PYR-1 AIGAG-CDRVLNLAAGLDTRPYRLPLSAEFS-----WVEADLPELIAEKE
Mb0289|M.bovis_AF2122/97 AAAAG-ARQVVILAAGLDSRAYRLPWPDGTT-----VFELDRPQVLDFKR
Rv0281|M.tuberculosis_H37Rv AAAAG-ARQVVILAAGLDSRAYRLPWPDGTT-----VFELDRPQVLDFKR
TH_4502|M.thermoresistible__bu AAEAG-IRQVVILASGLDSRAYRLPWPDGTV-----VYEIDQPKVLEYKS
MUL_4762|M.ulcerans_Agy99 AVAAG-IRQVVILASGLDSRAYRLDWPAGTT-----VYEIDQPQVLAYKS
MAB_4607c|M.abscessus_ATCC_199 AAAAG-IRQVVILASGLDSRAYRLDWPAGTT-----VYEIDQPQVLKFKD
MSMEG_0607|M.smegmatis_MC2_155 ATTH--VDQVVLLAAGMDARAFRLAWPAGTV-----VYELDQPEVIAAKS
Mflv_2136|M.gilvum_PYR-GCK YLVDHPRATVVALAEGLQTSFYRLDSGPESVGHDFRWLTVDLPPMIDLRT
MAV_2762|M.avium_104 QVLADEVPRCRLTRTAVDLADGVARDAFLNEALDGATKALVL-TEGLLMY
MMAR_2904|M.marinum_M QLLSGETPRCQLTRSAVDLADPAARDAFFTEALAGAAKALVL-TEGLLMY
MLBr_01972|M.leprae_Br4923 ---------------VVDLTDSHSREAFFNEALGGATKVLVMITEGLVMY
Mvan_5836|M.vanbaalenii_PYR-1 QLLAGESPRCRLTRHPVDLSDPVARDRFLDEALSGATKALVL-TEGLLMY
Mb0289|M.bovis_AF2122/97 EVLASHGAQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLLIY
Rv0281|M.tuberculosis_H37Rv EVLASHGAQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLLIY
TH_4502|M.thermoresistible__bu ATLAAHGVQPAADRREVAVDLRHDWPKALRAKGFDPQQRTAWLAEGLLMY
MUL_4762|M.ulcerans_Agy99 ATLAENGVTPAAERREVAIDLRQDWPSALRAAGFDPSARTAWLAEGLLMY
MAB_4607c|M.abscessus_ATCC_199 SALAAH--QPTAQRRGVAIDLREDWPAALRAAGFDSAQPTAWLAEGLLPY
MSMEG_0607|M.smegmatis_MC2_155 GLLADAS--PRCRWTALGVDLTRDWTTALRSTTFDPARPAVWLAEGLLQY
Mflv_2136|M.gilvum_PYR-GCK KLLPPS---------DRVRTLAQSALDFSWMDQVDTSEGVFITAEGLLMY
.. :***: *
MAV_2762|M.avium_104 LD-DSDVSALSAALQRPEVRWWMLDFAGPGLKKMMNKKMAGMLANAPFKF
MMAR_2904|M.marinum_M LD-EPDVIALSEAIRQPQVGWWMLDLAGPALKKMMNKKMAGMLQNAPFKF
MLBr_01972|M.leprae_Br4923 LD-DRDVILLSEVITRSEVTWWVLDLAGPGLKK-----------------
Mvan_5836|M.vanbaalenii_PYR-1 LD-PSDVDDLSRALVRSEVAWWMLDLAGPGLKKWMNDNTGGLLRNAPFKF
Mb0289|M.bovis_AF2122/97 LP-ATAQERLFTGIDALAGRRSHVAVEDGAPMGPDEYAAKVEE--ERAAI
Rv0281|M.tuberculosis_H37Rv LP-ATAQERLFTGIDALAGRRSHVAVEDGAPMGPDEYAAKVEE--ERAAI
TH_4502|M.thermoresistible__bu LP-ADAQDRLFENITALSAPGSRLAVET-AAEEPVDRREQMRARMERIAS
MUL_4762|M.ulcerans_Agy99 LP-AEAQDRLFTQIGELSCAGSRIAAET-AGNHADERREQMRERFRKVAQ
MAB_4607c|M.abscessus_ATCC_199 LP-ADAQDNLFRDIGVLSAAGSRVAVEGYEGKLVLDESEEEAVRREQVRA
MSMEG_0607|M.smegmatis_MC2_155 LD-ETAVHTLFDRVDAMSAPGS-VLLYDVVGKTLLDAAMLAAVRESMARS
Mflv_2136|M.gilvum_PYR-GCK LQPAEAMSLITECAARFPGGQMIFDLPPSAFAFLVGRGVRASLRYRVPPM
* : .
MAV_2762|M.avium_104 APD---------NGLAYFENLGWRTVQVEALYSAARRLRRLPLVMRPLGW
MMAR_2904|M.marinum_M APD---------NGLAFFEALGWHVAEAESLFTAAQRFRRLPISMRSLGW
MLBr_01972|M.leprae_Br4923 --------------------------------------------------
Mvan_5836|M.vanbaalenii_PYR-1 APA---------NGVGYFEQLGWRTREVESVFVVARRLRRLPWLLRLVAW
Mb0289|M.bovis_AF2122/97 AEG---AEEHPFFQLVYNER-CAPAAEWFGERGWTAVATLLNDYLEAVGR
Rv0281|M.tuberculosis_H37Rv AEG---AEEHPFFQLVYNER-CAPAAEWFGERGWTAVATLLNDYLEAVGR
TH_4502|M.thermoresistible__bu QFG--LEKALDVAQLMYDDPDRADVPEWLTGHGWRTEWVSAPDEMRRLDR
MUL_4762|M.ulcerans_Agy99 TLG--LEQTIDVHELIYHDPDRAPLGQWLNEHGWRANAQNACDEMHRVGR
MAB_4607c|M.abscessus_ATCC_199 AFKTAIDVDVTIENLIYEDENRADPAEWLDAHGWSVTKTDAHDEMARLGR
MSMEG_0607|M.smegmatis_MC2_155 GAP--------------WRFGTDAPGELSTRLGWSANVTDIAEPGNAYGR
Mflv_2136|M.gilvum_PYR-GCK PFS---------LTIAEAADLVNTVPGVRAVHDLPAEHARG-RLINALLW
MAV_2762|M.avium_104 LPQPDPRRP--------GRRAWSAAALLTH--
MMAR_2904|M.marinum_M LPQPNPRHP--------GRRPWSAVTLLTQ--
MLBr_01972|M.leprae_Br4923 --------------------------------
Mvan_5836|M.vanbaalenii_PYR-1 LPQPDPHRPP-------ADRPWSAVVRLTR--
Mb0289|M.bovis_AF2122/97 PVPGPESEAG-------PMFARNTLVSAARV-
Rv0281|M.tuberculosis_H37Rv PVPGPESEAG-------PMFARNTLVSAARV-
TH_4502|M.thermoresistible__bu FVAAAMPPGDDADAADLDDTAFSKFVTAERPS
MUL_4762|M.ulcerans_Agy99 WVEG-VPMAD-------DKQAYSDFVTAERL-
MAB_4607c|M.abscessus_ATCC_199 PVAEDVERGT----------FRGQLIQGELR-
MSMEG_0607|M.smegmatis_MC2_155 WFTPAVPLDVP-------GVPRGYFVEATKPG
Mflv_2136|M.gilvum_PYR-GCK TAQRVPLLDP----------IRPMFTLLEFG-