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VRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAFCRAVGGSWADVLDGKLPDHKLKSTDF GEHFVNFQGARTKYFDEYFRRAAAAGARQVVILAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLAS HGAQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLLIYLPATAQERLFTGIDALAGRRSHVAV EDGAPMGPDEYAAKVEEERAAIAEGAEEHPFFQLVYNERCAPAAEWFGERGWTAVATLLNDYLEAVGRPV PGPESEAGPMFARNTLVSAARV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0281 | - | - | 100% (302) | hypothetical protein Rv0281 |
| M. tuberculosis H37Rv | Rv0893c | - | e-117 | 69.10% (301) | hypothetical protein Rv0893c |
| M. tuberculosis H37Rv | Rv0146 | - | 2e-63 | 44.73% (313) | hypothetical protein Rv0146 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0289 | - | 1e-176 | 100.00% (302) | hypothetical protein Mb0289 |
| M. gilvum PYR-GCK | Mflv_0743 | - | 3e-66 | 46.26% (294) | putative methyltransferase |
| M. leprae Br4923 | MLBr_02640 | - | 2e-64 | 45.83% (288) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_4328c | - | 5e-91 | 56.11% (303) | hypothetical protein MAB_4328c |
| M. marinum M | MMAR_0539 | - | 1e-140 | 80.07% (301) | O-methyltransferase |
| M. avium 104 | MAV_4873 | - | 1e-138 | 80.73% (301) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_0614 | - | 1e-105 | 63.79% (301) | methyltransferase |
| M. thermoresistible (build 8) | TH_4502 | - | 8e-67 | 46.53% (303) | PUTATIVE methyltransferase |
| M. ulcerans Agy99 | MUL_4402 | - | 2e-66 | 48.17% (301) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0104 | - | 9e-64 | 45.49% (288) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0281|M.tuberculosis_H37Rv ---MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAFCRA
Mb0289|M.bovis_AF2122/97 ---MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAFCRA
MAV_4873|M.avium_104 ---MRSEGDTWDITTSVGSTALFVATARALEAQKPDPLAVDPYAEIFCRA
MMAR_0539|M.marinum_M ---MRSEGDSWDITTSVGSTALFVATARALEALKPDPLAVDPYAELFCRA
MSMEG_0614|M.smegmatis_MC2_155 ---MRTDNDQWDITISVGQTALFVAASRALEARKPHPLAVDHYAEVFCRA
MAB_4328c|M.abscessus_ATCC_199 ---MRTDRDNWDINTSVGSTALFVAASRALEATKPAPLAADQYAEVFCRA
Mflv_0743|M.gilvum_PYR-GCK MSSLRTDDDTWDIASSVGATAVMVAAARAAETERHDALINDPYAKVLVEG
Mvan_0104|M.vanbaalenii_PYR-1 MSSLRTDNDTWDIASSVGATAVMVAAARAAETERPEPLIDDPYAKILVAG
TH_4502|M.thermoresistible__bu MSSLRTDDDTWDIATSVGSTAVMVAASRAAETEREDALIRDPYAKVLVAG
MLBr_02640|M.leprae_Br4923 ---MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTN
MUL_4402|M.ulcerans_Agy99 --MPRTDNDSWTITESVGATALGVAAARAAETESENPLIEDPFARVFVDA
*:. * * * *** **: **::** *: .* * :*. :
Rv0281|M.tuberculosis_H37Rv VGGS--WADVLD----GKLPDHKLKSTDFGEHFVNFQGARTKYFDEYFRR
Mb0289|M.bovis_AF2122/97 VGGS--WADVLD----GKLPDHKLKSTDFGEHFVNFQGARTKYFDEYFRR
MAV_4873|M.avium_104 VGGS--AADVLD----GKDPDHQLKTDDFGVHFVNFQGARTKYFDEYFRR
MMAR_0539|M.marinum_M VGGS--WADVLD----GNAADHELQSDDFGKHFVNFQGARTKYFDAYFRR
MSMEG_0614|M.smegmatis_MC2_155 AGGD--WVAAVE----GTDPEHPLQT-EFGVDFVNFQGARTKYFDDYFRR
MAB_4328c|M.abscessus_ATCC_199 AGGE--WAELVA----GGVPEHPLRSEDFGQYFVSFQGARTRYFDTYFGK
Mflv_0743|M.gilvum_PYR-GCK AGAG-AWRFIADEDLVAKASESDTEVGALFEHMKNYQAVRTHFFDAFFSA
Mvan_0104|M.vanbaalenii_PYR-1 AGNG-AWQYIADDGFVAKVTESDPEIGPLFEHMKNYQAVRTHFFDAFFAA
TH_4502|M.thermoresistible__bu AGTG-VWELILDDDFTAKIEAADPETAAIFDHMGNYQAVRTHFFDTYFAR
MLBr_02640|M.leprae_Br4923 TGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNN
MUL_4402|M.ulcerans_Agy99 AGDG-MWSMFANPALLAGAPEIESQVGARVRQMIDFMATRTAFFDEFFLG
.* . . : .: ..** :** :*
Rv0281|M.tuberculosis_H37Rv AAAAGARQVVILAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLASH
Mb0289|M.bovis_AF2122/97 AAAAGARQVVILAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLASH
MAV_4873|M.avium_104 AADAGVRQVVILAAGLDSRAYRLDWPAATTIFELDQPQVLDFKREVLAGV
MMAR_0539|M.marinum_M AVEAGVRQVVVLAAGLDSRAYRLSWPDGTTIFELDRPQVLDFKREVLGGH
MSMEG_0614|M.smegmatis_MC2_155 VADAGVRQVVLLAAGLDSRAYRLPWADGTVVYELDVPKVLEFKREVLRRH
MAB_4328c|M.abscessus_ATCC_199 AIEAGVKQVVILASGLDSRAYRLDWAPGTTVFELDQPLVHQFKREALDQH
Mflv_0743|M.gilvum_PYR-GCK AVDAGVRQIVILASGLDSRAFRLPWPAGTVVYEIDQPLVLDYKSSTLAAH
Mvan_0104|M.vanbaalenii_PYR-1 AVDAGIRQIVILASGLDSRAFRLPWPAGTTVFEIDQPLVLAYKSSTLASH
TH_4502|M.thermoresistible__bu AAEAGIRQVVILASGLDSRAYRLPWPDGTVVYEIDQPKVLEYKSATLAAH
MLBr_02640|M.leprae_Br4923 AVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEH
MUL_4402|M.ulcerans_Agy99 AADAGVRQVVILASGLDSRAWRLPWPDGTVVYELDQPRVLEFKSATLRQH
. * :*.*:**:******:** *. .*.::*:* * * :* .*
Rv0281|M.tuberculosis_H37Rv GAQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLLIYLPATAQ
Mb0289|M.bovis_AF2122/97 GAQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLLIYLPATAQ
MAV_4873|M.avium_104 DAHPRAERREIAVDLREDWPQALRDSGFDPDKPSAWIAEGLLIYLPASAQ
MMAR_0539|M.marinum_M GVRPRTERREIAVDLRDDWPQALRDSGFDAEAPSAWIAEGLLIYLPAAAQ
MSMEG_0614|M.smegmatis_MC2_155 GATPTAERREVPVDLRDDWPAALRANGFDASQPSAWIAEGLLIYLPADAQ
MAB_4328c|M.abscessus_ATCC_199 GAEPKAVRAEISVDLREDWGKALQDKGFDPSEPSAWLVEGLLIYLPADAQ
Mflv_0743|M.gilvum_PYR-GCK GVAPTAERREVPIDLRQDWPAALVATGFDPARPTAWLAEGLLMYLPADAQ
Mvan_0104|M.vanbaalenii_PYR-1 GVQPTADRREVPIDLRQDWPTALTHAGFDADQPTAWLAEGLLMYLPADAQ
TH_4502|M.thermoresistible__bu GVQPAADRREVAVDLRHDWPKALRAKGFDPQQRTAWLAEGLLMYLPADAQ
MLBr_02640|M.leprae_Br4923 GVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQ
MUL_4402|M.ulcerans_Agy99 GARPTAQLMNIPIDLRQDWPAALLDSGFDASKPTAWSAEGLVRYLPARAQ
.. * : ::.:***.** ** ***. :** .***: **** **
Rv0281|M.tuberculosis_H37Rv ERLFTGIDALAGRRSHVAVEDG-APMGPDEYAAKVEEERAAIAEGAE---
Mb0289|M.bovis_AF2122/97 ERLFTGIDALAGRRSHVAVEDG-APMGPDEYAAKVEEERAAIAEGAE---
MAV_4873|M.avium_104 EQLFTGIDALAGHGSHVAVEEG-APMTPEDFEAAVAAERAANEQG-E---
MMAR_0539|M.marinum_M EQLFTGIDSLACLGSHVAVEDG-APLPDAEFAAKLEEERAAVAAG-G---
MSMEG_0614|M.smegmatis_MC2_155 ELLFAGIDALSAPGSFVAIEES-APMPMDVFEVKRAEALAS---G-D---
MAB_4328c|M.abscessus_ATCC_199 ERLFESIDQLAAPGSFVGIEQM-TTYADVVFAMLVAGANESGDQA-----
Mflv_0743|M.gilvum_PYR-GCK DRLFAQITELSAPGSQVAAES--MGVHAPDRRERMRERFASIASQID--I
Mvan_0104|M.vanbaalenii_PYR-1 DRLFAQITELSAPGSRVAAES--MGIHAQDRRERMRERFASITAQFD--V
TH_4502|M.thermoresistible__bu DRLFENITALSAPGSRLAVET--AAEEPVDRREQMRARMERIASQFG--L
MLBr_02640|M.leprae_Br4923 DGLFTEIGGLSAVGSRIAVET--SPLHGDEWREQMQLRFRRVSDALG--F
MUL_4402|M.ulcerans_Agy99 DLLFERIDTLSPAGSWLATNVPQGGFLDPDLVRRQHEEMQRMRAAAGRLV
: ** * *: * :. :
Rv0281|M.tuberculosis_H37Rv --EHPFFQLVYNE-RCAPAAEWFGERGWTAVATLLNDYLEAVGRPVP---
Mb0289|M.bovis_AF2122/97 --EHPFFQLVYNE-RCAPAAEWFGERGWTAVATLLNDYLEAVGRPVP---
MAV_4873|M.avium_104 --QRMFFQLVYNE-QCAPAAEWFGSRGWTAVPTPLADYLRQVGRPVP---
MMAR_0539|M.marinum_M --ERPFFQLLYNE-RCAPAADWFSEHGWTALGTPLNNYLREVGRPVP---
MSMEG_0614|M.smegmatis_MC2_155 --PNSFFALVFNE-QCAPGEQWFSERGWTASTTTLNECLHEVGRPAP---
MAB_4328c|M.abscessus_ATCC_199 --NSDFFSLIYNE-QRSEAATWFRCHGWDSERTELLDYLNFSGRTLP---
Mflv_0743|M.gilvum_PYR-GCK EP-MDITELTYEDPDRAEVAEWLAAHGWTAQAVPSQDAMRRLDRYV----
Mvan_0104|M.vanbaalenii_PYR-1 EP-MDITELTYEDPDRADVAQWLTAHGWRAEAVPSQDEMRRLHRLV----
TH_4502|M.thermoresistible__bu EKALDVAQLMYDDPDRADVPEWLTGHGWRTEWVSAPDEMRRLDRFVAAAM
MLBr_02640|M.leprae_Br4923 EQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWG----
MUL_4402|M.ulcerans_Agy99 EIQMPAVEDLWYAEERTPVADWLGEHGWRASATTSAELLTRYGRPV----
: : *: :** : : : *
Rv0281|M.tuberculosis_H37Rv ----GPESEAGPMFARNTLVSAARV--
Mb0289|M.bovis_AF2122/97 ----GPESEAGPMFARNTLVSAARV--
MAV_4873|M.avium_104 ----GPDTEAGPMIARNTLVSAVRA--
MMAR_0539|M.marinum_M ----GPGSEVAAMFARNTLMSATKP--
MSMEG_0614|M.smegmatis_MC2_155 ----APDSEAAQMTGSISLMWARKG--
MAB_4328c|M.abscessus_ATCC_199 ----EPSQPAWYMFNSISLVSAVKG--
Mflv_0743|M.gilvum_PYR-GCK ------EVADSDGQSFSTFTTGTKL--
Mvan_0104|M.vanbaalenii_PYR-1 ------EIADGDDQSFSTFTTAVKR--
TH_4502|M.thermoresistible__bu PPGDDADAADLDDTAFSKFVTAERPS-
MLBr_02640|M.leprae_Br4923 ---DGVPMAD-DKDAFAEFVTAHRL--
MUL_4402|M.ulcerans_Agy99 ------PDDAEGPVPPTLFVSAHRPAA
: . :