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VRSEGDSWDITTSVGSTALFVATARALEALKPDPLAVDPYAELFCRAVGGSWADVLDGNAADHELQSDDF GKHFVNFQGARTKYFDAYFRRAVEAGVRQVVVLAAGLDSRAYRLSWPDGTTIFELDRPQVLDFKREVLGG HGVRPRTERREIAVDLRDDWPQALRDSGFDAEAPSAWIAEGLLIYLPAAAQEQLFTGIDSLACLGSHVAV EDGAPLPDAEFAAKLEEERAAVAAGGERPFFQLLYNERCAPAADWFSEHGWTALGTPLNNYLREVGRPVP GPGSEVAAMFARNTLMSATKP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0539 | - | - | 100% (301) | O-methyltransferase |
| M. marinum M | MMAR_0357 | - | 9e-65 | 46.08% (293) | O-methyltransferase |
| M. marinum M | MMAR_5323 | - | 1e-64 | 46.92% (292) | O-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0289 | - | 1e-140 | 80.07% (301) | hypothetical protein Mb0289 |
| M. gilvum PYR-GCK | Mflv_0743 | - | 4e-65 | 44.29% (289) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv0281 | - | 1e-140 | 80.07% (301) | hypothetical protein Rv0281 |
| M. leprae Br4923 | MLBr_02640 | - | 1e-65 | 45.83% (288) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_4328c | - | 2e-92 | 55.45% (303) | hypothetical protein MAB_4328c |
| M. avium 104 | MAV_4873 | - | 1e-134 | 76.67% (300) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_0614 | - | 1e-105 | 63.67% (300) | methyltransferase |
| M. thermoresistible (build 8) | TH_4502 | - | 8e-67 | 45.02% (311) | PUTATIVE methyltransferase |
| M. ulcerans Agy99 | MUL_4762 | - | 4e-66 | 46.42% (293) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0104 | - | 2e-65 | 44.64% (289) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0289|M.bovis_AF2122/97 ---MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAFCRA
Rv0281|M.tuberculosis_H37Rv ---MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAFCRA
MAV_4873|M.avium_104 ---MRSEGDTWDITTSVGSTALFVATARALEAQKPDPLAVDPYAEIFCRA
MMAR_0539|M.marinum_M ---MRSEGDSWDITTSVGSTALFVATARALEALKPDPLAVDPYAELFCRA
MSMEG_0614|M.smegmatis_MC2_155 ---MRTDNDQWDITISVGQTALFVAASRALEARKPHPLAVDHYAEVFCRA
MAB_4328c|M.abscessus_ATCC_199 ---MRTDRDNWDINTSVGSTALFVAASRALEATKPAPLAADQYAEVFCRA
Mflv_0743|M.gilvum_PYR-GCK MSSLRTDDDTWDIASSVGATAVMVAAARAAETERHDALINDPYAKVLVEG
Mvan_0104|M.vanbaalenii_PYR-1 MSSLRTDNDTWDIASSVGATAVMVAAARAAETERPEPLIDDPYAKILVAG
TH_4502|M.thermoresistible__bu MSSLRTDDDTWDIATSVGSTAVMVAASRAAETEREDALIRDPYAKVLVAG
MLBr_02640|M.leprae_Br4923 ---MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTN
MUL_4762|M.ulcerans_Agy99 ---MRTHDDTWDIRTSVGATAVMVAAARAVETSKPEPLIRDPYARMLVTN
:*:. * *** *** **::**::** *: : .* * **. :
Mb0289|M.bovis_AF2122/97 VGGS--WADVLD----GKLPDHKLKSTDFGEHFVNFQGARTKYFDEYFRR
Rv0281|M.tuberculosis_H37Rv VGGS--WADVLD----GKLPDHKLKSTDFGEHFVNFQGARTKYFDEYFRR
MAV_4873|M.avium_104 VGGS--AADVLD----GKDPDHQLKTDDFGVHFVNFQGARTKYFDEYFRR
MMAR_0539|M.marinum_M VGGS--WADVLD----GNAADHELQSDDFGKHFVNFQGARTKYFDAYFRR
MSMEG_0614|M.smegmatis_MC2_155 AGGD--WVAAVE----GTDPEHPLQT-EFGVDFVNFQGARTKYFDDYFRR
MAB_4328c|M.abscessus_ATCC_199 AGGE--WAELVA----GGVPEHPLRSEDFGQYFVSFQGARTRYFDTYFGK
Mflv_0743|M.gilvum_PYR-GCK AGAG-AWRFIADEDLVAKASESDTEVGALFEHMKNYQAVRTHFFDAFFSA
Mvan_0104|M.vanbaalenii_PYR-1 AGNG-AWQYIADDGFVAKVTESDPEIGPLFEHMKNYQAVRTHFFDAFFAA
TH_4502|M.thermoresistible__bu AGTG-VWELILDDDFTAKIEAADPETAAIFDHMGNYQAVRTHFFDTYFAR
MLBr_02640|M.leprae_Br4923 TGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNN
MUL_4762|M.ulcerans_Agy99 ANAGVIWEAMLDQEMVAKVEAIDAETAATVEHMRSYQAVRTNFFDTYFAD
.. . . : .:*..**.:** :*
Mb0289|M.bovis_AF2122/97 AAAAGARQVVILAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLASH
Rv0281|M.tuberculosis_H37Rv AAAAGARQVVILAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLASH
MAV_4873|M.avium_104 AADAGVRQVVILAAGLDSRAYRLDWPAATTIFELDQPQVLDFKREVLAGV
MMAR_0539|M.marinum_M AVEAGVRQVVVLAAGLDSRAYRLSWPDGTTIFELDRPQVLDFKREVLGGH
MSMEG_0614|M.smegmatis_MC2_155 VADAGVRQVVLLAAGLDSRAYRLPWADGTVVYELDVPKVLEFKREVLRRH
MAB_4328c|M.abscessus_ATCC_199 AIEAGVKQVVILASGLDSRAYRLDWAPGTTVFELDQPLVHQFKREALDQH
Mflv_0743|M.gilvum_PYR-GCK AVDAGVRQIVILASGLDSRAFRLPWPAGTVVYEIDQPLVLDYKSSTLAAH
Mvan_0104|M.vanbaalenii_PYR-1 AVDAGIRQIVILASGLDSRAFRLPWPAGTTVFEIDQPLVLAYKSSTLASH
TH_4502|M.thermoresistible__bu AAEAGIRQVVILASGLDSRAYRLPWPDGTVVYEIDQPKVLEYKSATLAAH
MLBr_02640|M.leprae_Br4923 AVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEH
MUL_4762|M.ulcerans_Agy99 AVAAGIRQVVILASGLDSRAYRLDWPAGTTVYEIDQPQVLAYKSATLAEN
. * :*.*:**:******:** *. .*.::*:* * * :* .*
Mb0289|M.bovis_AF2122/97 GAQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLLIYLPATAQ
Rv0281|M.tuberculosis_H37Rv GAQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLLIYLPATAQ
MAV_4873|M.avium_104 DAHPRAERREIAVDLREDWPQALRDSGFDPDKPSAWIAEGLLIYLPASAQ
MMAR_0539|M.marinum_M GVRPRTERREIAVDLRDDWPQALRDSGFDAEAPSAWIAEGLLIYLPAAAQ
MSMEG_0614|M.smegmatis_MC2_155 GATPTAERREVPVDLRDDWPAALRANGFDASQPSAWIAEGLLIYLPADAQ
MAB_4328c|M.abscessus_ATCC_199 GAEPKAVRAEISVDLREDWGKALQDKGFDPSEPSAWLVEGLLIYLPADAQ
Mflv_0743|M.gilvum_PYR-GCK GVAPTAERREVPIDLRQDWPAALVATGFDPARPTAWLAEGLLMYLPADAQ
Mvan_0104|M.vanbaalenii_PYR-1 GVQPTADRREVPIDLRQDWPTALTHAGFDADQPTAWLAEGLLMYLPADAQ
TH_4502|M.thermoresistible__bu GVQPAADRREVAVDLRHDWPKALRAKGFDPQQRTAWLAEGLLMYLPADAQ
MLBr_02640|M.leprae_Br4923 GVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQ
MUL_4762|M.ulcerans_Agy99 GVTPAAERREVAIDLRQDWPSALRAAGFDPSARTAWLAEGLLMYLPAEAQ
.. * : * *:.:***.** ** ***. :**:.****:**** **
Mb0289|M.bovis_AF2122/97 ERLFTGIDALAGRRSHVAVEDGAPMGPDEYAAKVE--EERAAIAEGAEEH
Rv0281|M.tuberculosis_H37Rv ERLFTGIDALAGRRSHVAVEDGAPMGPDEYAAKVE--EERAAIAEGAEEH
MAV_4873|M.avium_104 EQLFTGIDALAGHGSHVAVEEGAPMTPEDFEAAVA--AERAANEQG-EQR
MMAR_0539|M.marinum_M EQLFTGIDSLACLGSHVAVEDGAPLPDAEFAAKLE--EERAAVAAG-GER
MSMEG_0614|M.smegmatis_MC2_155 ELLFAGIDALSAPGSFVAIEESAPMPMDVFEVKRA--EALAS---G-DPN
MAB_4328c|M.abscessus_ATCC_199 ERLFESIDQLAAPGSFVGIEQMTTYADVVFAMLVA--GANESGDQA--NS
Mflv_0743|M.gilvum_PYR-GCK DRLFAQITELSAPGSQVAAESMGVHAPDRRERMRERFASIASQIDIEP-M
Mvan_0104|M.vanbaalenii_PYR-1 DRLFAQITELSAPGSRVAAESMGIHAQDRRERMRERFASITAQFDVEP-M
TH_4502|M.thermoresistible__bu DRLFENITALSAPGSRLAVETAAEEPVDRREQMRARMERIASQFGLEKAL
MLBr_02640|M.leprae_Br4923 DGLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRRVSDALGFEQAV
MUL_4762|M.ulcerans_Agy99 DRLFTQIGELSCAGSRIAAETAGNHADERREQMRERFRKVAQTLGLEQTI
: ** * *: * :. *
Mb0289|M.bovis_AF2122/97 PFFQLVYNE-RCAPAAEWFGERGWTAVATLLNDYLEAVGRPVPG------
Rv0281|M.tuberculosis_H37Rv PFFQLVYNE-RCAPAAEWFGERGWTAVATLLNDYLEAVGRPVPG------
MAV_4873|M.avium_104 MFFQLVYNE-QCAPAAEWFGSRGWTAVPTPLADYLRQVGRPVPG------
MMAR_0539|M.marinum_M PFFQLLYNE-RCAPAADWFSEHGWTALGTPLNNYLREVGRPVPG------
MSMEG_0614|M.smegmatis_MC2_155 SFFALVFNE-QCAPGEQWFSERGWTASTTTLNECLHEVGRPAPA------
MAB_4328c|M.abscessus_ATCC_199 DFFSLIYNE-QRSEAATWFRCHGWDSERTELLDYLNFSGRTLPE------
Mflv_0743|M.gilvum_PYR-GCK DITELTYEDPDRAEVAEWLAAHGWTAQAVPSQDAMRRLDRYV--------
Mvan_0104|M.vanbaalenii_PYR-1 DITELTYEDPDRADVAQWLTAHGWRAEAVPSQDEMRRLHRLV--------
TH_4502|M.thermoresistible__bu DVAQLMYDDPDRADVPEWLTGHGWRTEWVSAPDEMRRLDRFVAAAMPPGD
MLBr_02640|M.leprae_Br4923 DVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDG------
MUL_4762|M.ulcerans_Agy99 DVHELIYHDPDRAPLGQWLNEHGWRANAQNACDEMHRVGRWVEG------
. * :.: : *: :** : : :. *
Mb0289|M.bovis_AF2122/97 -PESEAGPMFARNTLVSAARV-
Rv0281|M.tuberculosis_H37Rv -PESEAGPMFARNTLVSAARV-
MAV_4873|M.avium_104 -PDTEAGPMIARNTLVSAVRA-
MMAR_0539|M.marinum_M -PGSEVAAMFARNTLMSATKP-
MSMEG_0614|M.smegmatis_MC2_155 -PDSEAAQMTGSISLMWARKG-
MAB_4328c|M.abscessus_ATCC_199 -PSQPAWYMFNSISLVSAVKG-
Mflv_0743|M.gilvum_PYR-GCK --EVADSDGQSFSTFTTGTKL-
Mvan_0104|M.vanbaalenii_PYR-1 --EIADGDDQSFSTFTTAVKR-
TH_4502|M.thermoresistible__bu DADAADLDDTAFSKFVTAERPS
MLBr_02640|M.leprae_Br4923 -VPMAD-DKDAFAEFVTAHRL-
MUL_4762|M.ulcerans_Agy99 -VPMAD-DKQAYSDFVTAERL-
: . :