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MKGAKTMNPECMDPEHNNLFEALKRVAVELNQTRAQLREHEERADVPVAIVGVGCRYPGGVESAGGLWDV VVGGRDVISGFPVDRGWDVEGVFDPDPDALGKTYCRLGGFLDGADRFDAGFFGIGPSEALVMDPQQRLLL ECSWEALEDAGIDPVSLRGSVTGVFTGLMSSDYGAGRVSGDLEGYGLTSAAASVASGRVAYLLGLEGPAV SVDTACSSSLVALHLAASSLRSGECDVALAGGVTVMATPATFVGFSRQRGLAADGRCKAFAGAADGTGFS EGAGVVVLMRLSEARRRGLAVLGVIAGSAVNQDGASNGLTAPNGPAQQRVIEAALANAGLTAADVDVVEG HGTGTTLGDPIEAQALLATYGQARPADRPLWLGSIKSNMGHTQAAAGIAGVIKMVQAMRHELMPATLHVD VPSPHVDWSSGAVSLLTQPRPWPAVDGRPRRAGVSSFGISGTNAHVIVEQVCPEVVAEAVDVSPDSLPWV VSGKSEAAVAAQAKRLLAAVQADEGLDRLDVGFSLARRTAFEYRAVVLGEDRQQLISGLTELAAGQPGPT VLNGRAATVSKTVMVFPGQGSQWPGMGRELLAASPVFAEHMRLCAEALGEFVDWSLLDVVNGVAGAPTLD RVDVVQPVLWAMMVSLAQLWRSVGVVPDAVIGHSQGEIAAACVAGALSLRDGAAVVALRSRALVDLAGTG GMVAIACGVERVRELLADYGDRLSLAAVNGVAAVVVSGEAKALRGLTGRCEAEGMRARRIEVDYASHSAQ VESIGSSLVEALAGVRPRSSDIEFVSTVTGASVDGASLGADYWYRNIRQTVRFDRAVRYCHEQGCRTFVE ASPHPVLLAGIEESLAEGIGRPDSAGVIVIPTLGRNEGGVERFWMSLSQAWLAGVGVDWSAVFAGSGGRQ VGLPTYAFARRRFWLDGSASAADVGEAGLVAAGHALLGAVVEQPDTGAVVLTGRLSLARQPWLADHLVGG AVLFPGTGFVELAIRAGDEVGCGVVEELTLATPLVLNAGTAVQVQVVVGSAGQSGQRLVSMYSRADQPDQ HWVLHAQGSVAPAAVQPAAAASAELSTWPPAGAEAVDIGGLYERLARRGYGYGPAFQGLRAVWRRGRDVF AEVGLPNDDGLDLTDVGIHPALLDAALHAWLCVGGFGGDGEATVLPFSWQHLSLHGSGASRLRVRIAPAG PSAVSVELADGAGLPVLSVGSLTTRPVGAAQLQAAMSAGGDGTGRELLNVVWTPITFERDSVQRDGERRV VSWDDFLAGRCAAARDLDRDVAVVWQWESGGAESVVNTVYTATHRVLEVLQRWLADDLPAVLVVCTRGAM GLAGEAITDLAGAAVWGLVRSAQTEHPGRIVLIDTDTSMALPTVIGVGEPQLVVRAGDVYAARLARGRAA LRTPDAGQGWQLAATGGGTFDDVVLEPCPRSDEPLAVGQVRVALAALGVNFRDVLVVLGLYPGNKPTLGG EGAGVVVEVGPGVSGLEPGDRVLGLMSGRSECVVDQRLLVPIPAGWSFAEAASAPIVFLTAFYGLSDLAG LRRGESVLVHAATGGVGMAAIQLARLWGARVFVTASRGKWDTLRAMGFDDDQIADSRTLEFEEKFSAATG GRGIDVVLNALAGEFTDASLRLLAERGRFIEMGKTDIRDAQEVAQEHPGVSYRAFDLANEVAPQRLGQML AELMTLFAAGKLHRLPVKTWDVRCAPQAYQFVSQARHIGKVVLSAPTELRDALAAGTVLITGGTGLVGSV LARHLVSAYGVRNLVLVSRMGEQGAGVAELVDELSDAGARVLVAACDVADQSAVEKLIAGWGREYPALTG VIHAAGVLDDAVITSMTPDQVDSVLRAKVDGAWNLHHATRGLGLSMFVLCSSIAGVVGAPGQGNYAAANA FLDALVTDRRAHGLAGVSLGWGLWEQASGMTKHLRGSDVSRLSRGGFAAISAQQALDLFDAALIVDQPTV LAARLDRRALENPALNADLPTLFSDLITRPMRRNVDNDGTPTELALVNRLNMMNPDEQHDLLTEVVCTQA VMVLGRLNAADIDPNATFSDLGFDSLTAIELRNRLKTVTGLTLPPTLIFDHRAPSALAQHLGQQLCVTHQ HESHNAMAPADSEDEKLRSILSAISVADLRDAGLLDKLLRLRKDPDRNLRVDRVDRVDNVGTKQQELEGM INSLSPEELVAMALAEPSGGNRMDSGG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_0102 | - | - | 100% (2197) | polyketide synthase PKS |
M. marinum M | MMAR_3098 | - | 0.0 | 63.68% (2156) | polyketide synthase PKS |
M. marinum M | MMAR_2471 | pks7 | 0.0 | 61.06% (2098) | polyketide synthase Pks7 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1689 | pks7 | 0.0 | 61.52% (2139) | polyketide synthase pks7 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 37.25% (2145) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv1661 | pks7 | 0.0 | 61.62% (2139) | polyketide synthase pks7 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 57.72% (2131) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 36.18% (2192) | polyketide synthase |
M. avium 104 | MAV_3109 | - | 0.0 | 61.69% (2125) | RifB protein |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 36.58% (2187) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 35.55% (1851) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2005 | pks15/1 | 0.0 | 57.90% (2102) | polyketide synthase Pks15/1 |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 0.0 | 36.52% (2196) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK --------------MGSAAHQGE-SAHRFAIVGYAGRFPGARDAESFWEL MAB_0939|M.abscessus_ATCC_1997 --------------MDSAENPIE-STPRFAIIGYAARFPGAADAEEFWDV MSMEG_0408|M.smegmatis_MC2_155 --------------MVSAEHPIE-PTPSFAIIGYAARFPGAASAEEYWAL Mvan_1003|M.vanbaalenii_PYR-1 MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYALRFPGAADADEFWDV TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LADGRDAISEVPEDRWDVEAFFDPDPSTPGKVVTRRAGFVDDVSGFDAPF MAB_0939|M.abscessus_ATCC_1997 LREGRDAISEVPADRWDAEEFFDPEPGAPGKVVTRRAGFVEDVTGFDAPF MSMEG_0408|M.smegmatis_MC2_155 LRDGREAISDVPKDRWDIEEFFDPDPSTPGKVVTRRAGFVDDVTGFDAPF Mvan_1003|M.vanbaalenii_PYR-1 LRGGRDAISEVPQDRWDADEFFDADPEAAGKMVTRRAGFVEDVAGFDAPF TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANTNTGVFVGLATH MAB_0939|M.abscessus_ATCC_1997 FGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAETNSGVFVGLATH MSMEG_0408|M.smegmatis_MC2_155 FGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANSNTGVFVGLATH Mvan_1003|M.vanbaalenii_PYR-1 FGVSAREAMFMDPQHRLLLETAWRAVEHSGTAPSALAGTRTGVFMGLSTH TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACS MAB_0939|M.abscessus_ATCC_1997 DYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQGPSVAVDTACS MSMEG_0408|M.smegmatis_MC2_155 DYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACS Mvan_1003|M.vanbaalenii_PYR-1 DYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRISYRLGLQGPAVAVDTACS TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SSLVAIHQACQALRLGECDLALAGGANVILTPATMITFSNAHMLAPDGRC MAB_0939|M.abscessus_ATCC_1997 SSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFSHAHMLAPDGKC MSMEG_0408|M.smegmatis_MC2_155 SSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFSNAHMLAPDGRC Mvan_1003|M.vanbaalenii_PYR-1 SSLVAVHQACQALRLAECDVALAGGVNVLLSPATMINFSRARMLAPDGRC TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK KTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIRGSAINQDGASG MAB_0939|M.abscessus_ATCC_1997 KTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIRGSAINQDGASG MSMEG_0408|M.smegmatis_MC2_155 KTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIRGSAINQDGASG Mvan_1003|M.vanbaalenii_PYR-1 KTFDATADGYVRGEGCGVVVVKRLADAIRHGDRIRAVIRGSAVNQDGASG TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTSLGDPIEAQAAG MAB_0939|M.abscessus_ATCC_1997 GLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTSLGDPIEAQAAG MSMEG_0408|M.smegmatis_MC2_155 GLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTSLGDPIEAQAAG Mvan_1003|M.vanbaalenii_PYR-1 GLTVPNGAAQQRVIADALTNAGLTAADVDYLEAHGTGTPLGDPIEVQAAG TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AALGPGREPQRPLLIGSAKTNIGHLEAAAGIAGVIKVVLSLEHETLPKHL MAB_0939|M.abscessus_ATCC_1997 AAYGIGRETNDPLLIGSAKTNIGHLEAAAGIAGVIKVILSLENELLPQHR MSMEG_0408|M.smegmatis_MC2_155 EVLGAGRAPEEPLLIGSAKTNIGHLEAAAGIAGVIKVVMALENETLPKHL Mvan_1003|M.vanbaalenii_PYR-1 AVLGVGREPDRPLLIGSVKTNIGHLEAASGIAGLLKVILSLEHQVLPKHL TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPRIAGVSSFGFAGTNAH MAB_0939|M.abscessus_ATCC_1997 NFQNPSPHIPWDRLPVEVVREARPWGR---NGRPRIAGVSSFGFAGTNAH MSMEG_0408|M.smegmatis_MC2_155 NFETPSPHIPWERLPIEVVRETVPWQR---NGKPRIAGVSSFGFAGTNAH Mvan_1003|M.vanbaalenii_PYR-1 NFRSPSPHIPWNRLPVRIVDDPVPWTR---SGRSRVAGISSFGFSGTNAH TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VILEEAPLAAEPAQES---VDDGRFTLLPLSARTPAALMAVADRYRDWLV MAB_0939|M.abscessus_ATCC_1997 VILEEAPVVSRDAVEPPAPAGGRKFSILPLSARTPAALAQLADKYRAWLN MSMEG_0408|M.smegmatis_MC2_155 VILEEAPAVGTPATTEP-VEDPRRYSVLPLSARTPEALVRLAGEYRDWLR Mvan_1003|M.vanbaalenii_PYR-1 VLVEEAPRADRAGAAPQ-PAAPGGFGMLPLSARTPDALAATAHRLRTWLA TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ANPDATLADLCFTAGTARSHLEHRAALVVNTREAALDLLGALADDRPAPG MAB_0939|M.abscessus_ATCC_1997 AHPEAALADLCFTAGVGRAHLEHRAALVVNTREAAVELLSAVADDRPAPG MSMEG_0408|M.smegmatis_MC2_155 AHPQARLADVSHTAGTARAHLEQRAALVVNSRESAIELLGALADDRPAPG Mvan_1003|M.vanbaalenii_PYR-1 ANPDASWPDLCFTAAVGRSHLRHRAALVVDSRSSVEELLGALAEDRPGPG TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTEPLFAETLRECAAAVDG MAB_0939|M.abscessus_ATCC_1997 LGRGESHDTPKTAWLFTGQGSQYPGMARELFETEPVFADTLNRCAAAVAD MSMEG_0408|M.smegmatis_MC2_155 LVRGESHEAPKTAWLFTGQGSQYPGMARELFDTEPVFAETVRKCAEAVAD Mvan_1003|M.vanbaalenii_PYR-1 LARGECGDPPKTAWLFTGQGSQYPGMGRELFDTEPVYREVMTRCAEAVAD TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK MLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPALFAVEMGLARLWQSWG MAB_0939|M.abscessus_ATCC_1997 VLEKPLLDVIFDVD---GPEAEETLRQTSYAQPALFAVEMGLARLWQSWG MSMEG_0408|M.smegmatis_MC2_155 ILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPALFAVELGLARLWQSWG Mvan_1003|M.vanbaalenii_PYR-1 VLERPLLDVVFDAD------GGEALRHTSYAQPALYAVEMGLARLWQSWG TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAERGRLFGSLPSGGRMAA MAB_0939|M.abscessus_ATCC_1997 FEPDVVLGHSVGQYSAACVAEVFSLEDGARLIAERGRLFSSLPAGGRMAA MSMEG_0408|M.smegmatis_MC2_155 FEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAERGRLFGSLPAGGRMAA Mvan_1003|M.vanbaalenii_PYR-1 IEPDVVLGHSVGQYAAACVAGVMGLEDGAVLLAERGRLFGSLPEGGRMAA TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VFAAAERVEALTDEYPALSVAAYNGANTVLSGPATDLERAVAGLVADGVR MAB_0939|M.abscessus_ATCC_1997 VFTDAERAERLTDEFPSLSVAAYNGANTVLSGPAQDLEKAIAALVADGVR MSMEG_0408|M.smegmatis_MC2_155 VFTAPERAERLTDEYPSLSVAAYNGANTVLSGPAKDLESAVATLVADGVR Mvan_1003|M.vanbaalenii_PYR-1 VFAPADRVESCTVDSPLLSVAAYNGDNTVLSGPAGDLERAVAGFSAAGVR TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK CDWLETSHAFHSALLDPILDDFESYARGITFTAPQRILIDNRTGAALGRS MAB_0939|M.abscessus_ATCC_1997 CDFLETSHAFHSALLDPILDEFEAYANQFNYKTPQRILIDNRTGTALGRS MSMEG_0408|M.smegmatis_MC2_155 CDWLDTSHAFHSALLDPILDDFESFAQKLEYREPQRILIDNRTGSALGRS Mvan_1003|M.vanbaalenii_PYR-1 CDWLDTSHAFHSALLDPVLEEFESCADRFEFGTPQRTLVCNRSGEVLSRH TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VTLDAAYWRRHARQPVEFAKSVHTLADMNCKLLVEIGPRPVLTAAALSAW MAB_0939|M.abscessus_ATCC_1997 VKLDGAYWRRHARQPVEFAKSVRTLADMNCKVLLEIGPQPVLTAAALRAW MSMEG_0408|M.smegmatis_MC2_155 TRLDGAYWRRHARQPVEFAKSVRTLADMNCRVLLEIGPRPVLTATALAAW Mvan_1003|M.vanbaalenii_PYR-1 ARLDGQYWRRHARQPVRFAESVRTLADLGCRLLMEIGPQPVLTAAAMRTW TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PDPATSPRVIASLRRTTADQRQITEAVADAYVLGHLPRFAAFRRDGARVL MAB_0939|M.abscessus_ATCC_1997 PDPATAPRAIASLRRNTADHRQITEAAADAYVLGHLPDFGAFQHAPARKL MSMEG_0408|M.smegmatis_MC2_155 PDPATTPQVLASLRPTTADHRQITEAVAAAYAAGHLPDFRAFRQPDARKL Mvan_1003|M.vanbaalenii_PYR-1 PGTVTAPRVAASMRRKGSDRRQITEALAQAYVAGHRPETAARQHGRGRLL TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DLPTYPFEHRQYWFSDSRE---PVAAAPQR---GARTETVRLLEDGRIEE MAB_0939|M.abscessus_ATCC_1997 DLPTYPFERRQYWFSDKRDGDNRDAGNRQQNNGGPRTEAVRLLEDGKIEE MSMEG_0408|M.smegmatis_MC2_155 DLPTYPFEHRQFWFSDNRAIDRDTQTASAGSVTPHRTQAVRLLEDGQIEE Mvan_1003|M.vanbaalenii_PYR-1 DLPTYPFQHRAYWFP--------QGQARTAPTDPVHTETVRFLDEERIDE TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LAALLGGTVDDPFTFDVLNRLAAQHNQQRSTESIADDRYQIRWETAAEPP MAB_0939|M.abscessus_ATCC_1997 LANLLGGVDGDQQTLNVLTKLAAQHNLQRTTQTIADDRYQFRWEKSPTPL MSMEG_0408|M.smegmatis_MC2_155 LAALIDGETVDEQTLRVLNKLAARHNQQRSTHVDPDARYEIRWDAIASAA Mvan_1003|M.vanbaalenii_PYR-1 LAALLDGPTGSAQTVDVLSKLAARHRQQRGAQSIADARYQIRWEKSEAPG TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VGADAADGITWLLVGDDTDATRPLVDVLAARGHRYRILGLPKSGAEEHEL MAB_0939|M.abscessus_ATCC_1997 SGSQAAGGVTWLLVADAAGAAQPLLDVLTARGQQHRVLALPVSDADEAEL MSMEG_0408|M.smegmatis_MC2_155 ASTGAAA--DWILVGDDTAAVLEFADALTAGGHRHQIVALPGSDADEAQL Mvan_1003|M.vanbaalenii_PYR-1 AARPTTEATTWLLVTHDSRAAQPIAEVLERRGHPYHIVGLPGSDADAAPA TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ADTLRDAAADATDLRIVHVAALDAAESDTSMKSLLRMQHRVLGGTRRLFG MAB_0939|M.abscessus_ATCC_1997 VEALRSAADEDSALRIVHVAALAGQGS-SSAQSLLRIQHQVLGGTRRLFR MSMEG_0408|M.smegmatis_MC2_155 VDTLRAASAG--ELYVVHIAAGDGAAA--PMRDLLRVQHRTLGGLRRLFR Mvan_1003|M.vanbaalenii_PYR-1 EEALRATVSQ-PRPHILYLAALEEPGG-SAAETLGWMQHRVLAAARRLFQ TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AAVAAQLRSPMWLVTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWG MAB_0939|M.abscessus_ATCC_1997 AAAAAELRAPIWIVTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQVWG MSMEG_0408|M.smegmatis_MC2_155 AANDAELRSPIWLVTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPHIWG Mvan_1003|M.vanbaalenii_PYR-1 LAATAGARAPIWLITAGAQRITGDETVEPAQTSLWGFGRAAALEQPELWG TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GLADLGGGTSDEWSRLLNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDT MAB_0939|M.abscessus_ATCC_1997 GLADLSDAGTDEWAQFIGRVSVSGEASTREDQLALRGQAVHVPRLVRREE MSMEG_0408|M.smegmatis_MC2_155 GLADLSGADT-EWPRLIARITSPRDG---EDQIALRGDAVYAPRLVRRTG Mvan_1003|M.vanbaalenii_PYR-1 GLADVTTGDAEEWSALIDHIVAAPTS---EDQIAVRGREIHVARLTRCAE TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LPSGKPLHLRADATYLVTGGLGSLGLEIAGYLAANGAGHLVLTSRRTPDE MAB_0939|M.abscessus_ATCC_1997 LPSGKPLEVRSDATYLVTGGLGSIGLEIAGYLAGRGAKHLVLTSRREPGE MSMEG_0408|M.smegmatis_MC2_155 EPSDTPLPVREDRTYLVTGGLGAIGLEVAGYLASHGAGHVVLTSRREPGD Mvan_1003|M.vanbaalenii_PYR-1 KANAAALELRREATYLVTGGLGALGLEVAEFLASHGAGHLVLTGRRSASD TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AAASRIEALRERHGCEVRVVTADVADAHAVARLLATVQAEMPPLAGIVHA MAB_0939|M.abscessus_ATCC_1997 AARQRIDALAA-QGCEVRAVTADVADGHDVARLLAGIQAELPPLAGIVHA MSMEG_0408|M.smegmatis_MC2_155 DARRRLDGLREQYACDVRVITADVADAHDVARLMTTVAAELPPLAGIVHA Mvan_1003|M.vanbaalenii_PYR-1 TVRQRIDAMRERFDCQVLVATADVADRDDVARLFSTMRSELPPLAGIVHA TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AGEIGTTPLADLDDAEVDRVFAGKVWGAWHLSEATSDLQ--LDFFISTSS MAB_0939|M.abscessus_ATCC_1997 AGEIGTTPLSDLEDAEVDRVFAGKVWGAWHLSEAAAGLK--LDFFINTSS MSMEG_0408|M.smegmatis_MC2_155 AGEIGTTPLSGLDDAEVDRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSS Mvan_1003|M.vanbaalenii_PYR-1 AGEIGTSPLRTLDDAEMDRVFAGKVWGAVYLCEEVADMG--LDFFLATSS TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK IASVWGGFGQAAYGAANAFLDGLAWRLREQGVAGVSVNFGPWSAGMADAQ MAB_0939|M.abscessus_ATCC_1997 IAAVWGGYGQTAYSAANAFLDGLAWRLREQGIAGTSVNFGPWSAGMADAE MSMEG_0408|M.smegmatis_MC2_155 IASVWGGFGQTAYGAANAFLDGLAWRLRERGVTAVSVNFGPWAAGMADAE Mvan_1003|M.vanbaalenii_PYR-1 IASVWGSHGQTAYGAANAFLDGLADSLRARGIPGISVNFGPWAAGMADAK TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MMAR_0102|M.marinum_M -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SRARLEQRGIKTLSPADALAGLSDAVISAAP---HPVVARVDWSRFLPLY MAB_0939|M.abscessus_ATCC_1997 SRARLEQRGIKTLSPTDALAGLADVVAASGSNAVQGVIARIDWARFLPLY MSMEG_0408|M.smegmatis_MC2_155 SRARLEQRGVRTLSPAEALAGMADVVAGPVQ----GVVAKIDWSRFLPLY Mvan_1003|M.vanbaalenii_PYR-1 AREQLSRRGVKTLAPADALAGMADVIAASTA---HAVVARIDWATFLPVY TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------MNSTPED Rv1661|M.tuberculosis_H37Rv -------------------------------------------MNSTPED MAV_3109|M.avium_104 -------------------------------------------MSGDTEE MMAR_0102|M.marinum_M --------------------------------MKGAKTMNPECMDPEHNN MLBr_00135|M.leprae_Br4923 ------------------------------------MTASVEGADQKSEK MUL_2005|M.ulcerans_Agy99 ------------------------------------MTTSGESADQQNDK Mflv_0405|M.gilvum_PYR-GCK QQAGRRGFLAELERELPAAPAQQGPAVTASGRTPLVERLTTAPLQQRKRL MAB_0939|M.abscessus_ATCC_1997 QQAGKRGFLAELDREVPSHLA--GVAGAQSGSTQLVERLANAPVQQRKKL MSMEG_0408|M.smegmatis_MC2_155 QQAGRRAFLSELESELPAAATGAAAPATVPGKPPLVEQLTKAPVQQRKSL Mvan_1003|M.vanbaalenii_PYR-1 QLQRRRAFLSQLEREVPDVPD--ASAPAPSGTTRFVEELTLAPVEQRRKL TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 LVKALRRSLKQNE------------------------RLKRENRD----- Rv1661|M.tuberculosis_H37Rv LVKALRRSLKQNE------------------------RLKRENRD----- MAV_3109|M.avium_104 LVRALRQSLKENE------------------------RLKRENRR----- MMAR_0102|M.marinum_M LFEALKRVAVELN------------------------QTRAQLRE----- MLBr_00135|M.leprae_Br4923 LISYLKKVVVELD------------------------ETRARLRE----- MUL_2005|M.ulcerans_Agy99 LFRYLKKVAVELD------------------------EARARLRE----- Mflv_0405|M.gilvum_PYR-GCK LTDYLRDAVAEVTRVDAAEIREDAGFFDLGMDSLMAVELRRRIETGVGKE MAB_0939|M.abscessus_ATCC_1997 LTDYLRDAVAEVTRVDVSEIREDAGFFDLGMDSLMAVELRRRMEQGVGKE MSMEG_0408|M.smegmatis_MC2_155 ITNYLRNAVAEVTRVDADEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKD Mvan_1003|M.vanbaalenii_PYR-1 VLEYLRAAVAEVTRVDAAEIRDEAGFFDLGMDSLMAIELRRRLEQGLGKE TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 ---------------------------------------LLARTTEPVAV Rv1661|M.tuberculosis_H37Rv ---------------------------------------LLARTTEPVAV MAV_3109|M.avium_104 ---------------------------------------YLVAATEPVAV MMAR_0102|M.marinum_M ---------------------------------------HEERADVPVAI MLBr_00135|M.leprae_Br4923 ---------------------------------------YEQRATEPVAV MUL_2005|M.ulcerans_Agy99 ---------------------------------------YEQRATEPVAV Mflv_0405|M.gilvum_PYR-GCK IPVTLVMDHPRLSDAADYLLGDVLGLTEAAT-APKAATVVSTAADEPIAI MAB_0939|M.abscessus_ATCC_1997 IPVTLVMDHPRISDVADYLLGDVLGLAEQAKPAAQLASAVTGRTDEPIAI MSMEG_0408|M.smegmatis_MC2_155 IPVTLVMDHPRLSDAADYLLVEVLGLGEQTN--VRQASTVTARTDDPIAV Mvan_1003|M.vanbaalenii_PYR-1 LPVTLAMDHPHLSDAAEYVLGDVLGLSEHTV--AQPDTPSTVRTDDPIAI TH_4621|M.thermoresistible__bu ------------------------------------VNIVGDTPVNAVAV . .:*: Mb1689|M.bovis_AF2122/97 VGMGCRYPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAV Rv1661|M.tuberculosis_H37Rv VGMGCRYPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAV MAV_3109|M.avium_104 VGMGCRYPGGVDSPEALWEMVVEGRDVVSEFPADRGWDLAGLFDADPDAV MMAR_0102|M.marinum_M VGVGCRYPGGVESAGGLWDVVVGGRDVISGFPVDRGWDVEGVFDPDPDAL MLBr_00135|M.leprae_Br4923 VGIGCRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAE MUL_2005|M.ulcerans_Agy99 VGIGCRFPGGADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAE Mflv_0405|M.gilvum_PYR-GCK VAVSCRFPG-APNPEAFWDLLSGGVDAIREVPEDR-FDIDEFYDPDPDAA MAB_0939|M.abscessus_ATCC_1997 VAVSCRFPG-APDPEAFWDVLSGGVDAIREVPEDR-FDIDEFYDPDPEVA MSMEG_0408|M.smegmatis_MC2_155 VAVSCRFPG-APDPESFWELLAGGVDAIREVPEDR-WDIDEFYDPDPDTP Mvan_1003|M.vanbaalenii_PYR-1 VGMACRFPG-ADDTDAFWSVLAEGADLIREIPDDR-FDINEFYDPDPEAA TH_4621|M.thermoresistible__bu IGMACRLPGGIDSPQRLWEALLRGDDMVTEIPVDR-WDADDYFDPEPGVP :.:.** ** .. :*. : * : .* ** :* :*.:* . Mb1689|M.bovis_AF2122/97 GKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERA Rv1661|M.tuberculosis_H37Rv GKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERA MAV_3109|M.avium_104 GKSYCRCGGFLTGVGDFDAAFFGIAPSEALAMDPQQRLLLEVSWEALERA MMAR_0102|M.marinum_M GKTYCRLGGFLDGADRFDAGFFGIGPSEALVMDPQQRLLLECSWEALEDA MLBr_00135|M.leprae_Br4923 GKTYTRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYA MUL_2005|M.ulcerans_Agy99 GKTYTRWGAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHA Mflv_0405|M.gilvum_PYR-GCK GKTYTRYGGFLDHIDEFDPEFFGLSPREAVWIEPQQRLMLETVWEGLERA MAB_0939|M.abscessus_ATCC_1997 GKTYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERA MSMEG_0408|M.smegmatis_MC2_155 GKTYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERA Mvan_1003|M.vanbaalenii_PYR-1 GKIYSRYGGFLDGVDGFDPEFFGISPREAVWIDPQQRLVLETAWEGLERA TH_4621|M.thermoresistible__bu GRTVSRWGAFLDDVAGFDPEFFGISEREAISIDPQQRLLLETSWEAMEHA *: * *.*: **. ***: *.: ::*****:** **.:* * Mb1689|M.bovis_AF2122/97 GIDPITLRGSQTGVFAGVFHGSYGG--QGRVPGDLERYGLRGSTLSVASG Rv1661|M.tuberculosis_H37Rv GIDPITLRGSQTGVFAGVFHGSYGG--QGRVPGDLERYGLRGSTLSVASG MAV_3109|M.avium_104 GIDPATLRGSATGVFAGIFHGSYGG--QGRVPGNLERYGLRGSTLSVASG MMAR_0102|M.marinum_M GIDPVSLRGSVTGVFTGLMSSDYG---AGRVSGDLEGYGLTSAAASVASG MLBr_00135|M.leprae_Br4923 GIDPLSLRGSATGVFTGIFAPSYG----SRDTGGLQGYGLTGTAVSVASG MUL_2005|M.ulcerans_Agy99 GIDPMSLRGSSTGVFTGIFAPSYG----GKDVGALQGYGLTGSPVSVASG Mflv_0405|M.gilvum_PYR-GCK GYAPSALRGSRTGVFVGVAANEYAHLLSAESIDKIEPHFITGNALNAISG MAB_0939|M.abscessus_ATCC_1997 GYSPAALRGSRTGIFAGVGANEYAHLLSSESIDKIEPYFITGNALNAISG MSMEG_0408|M.smegmatis_MC2_155 GYAPSDLRGSRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISG Mvan_1003|M.vanbaalenii_PYR-1 GYSAAALRGSRSGVYVGVGANEYSHLLSGGSLDGIEAQFITGNALNVIAG TH_4621|M.thermoresistible__bu GLTPADVEGSSTGVFVGLSHDDYALL-TSDAGALEEAYGFTGSAFSMASG * . :.** :*::.*: .*. . : : . . . :* Mb1689|M.bovis_AF2122/97 RVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMA Rv1661|M.tuberculosis_H37Rv RVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMA MAV_3109|M.avium_104 RVAYALGLEGPAVSVDTACSSSLVALHLAAQSLRSGECDLALAGGVTVMA MMAR_0102|M.marinum_M RVAYLLGLEGPAVSVDTACSSSLVALHLAASSLRSGECDVALAGGVTVMA MLBr_00135|M.leprae_Br4923 RVSYVLGLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMG MUL_2005|M.ulcerans_Agy99 RVAYVLGLEGPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMG Mflv_0405|M.gilvum_PYR-GCK RVAFALGLEGPAVAVDTACSSSLVAVHQATQALRSGDCDMALAGGVNVLL MAB_0939|M.abscessus_ATCC_1997 RVAFALGFEGPAVAVDTACSSALVAVHQAVQALHSGDCDLALAGGVNVLL MSMEG_0408|M.smegmatis_MC2_155 RVAFALGFEGPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLL Mvan_1003|M.vanbaalenii_PYR-1 RVSFTLGLEGPAVAVDTACSSSLVAVHQACQGLQSGDCDLALAGGVNVLL TH_4621|M.thermoresistible__bu RIAYRLGVHGPAVTVDTACSSSLLAVHMACRSLQVGESDLALAGGAMVML *::: **..***::*******:*:*:* * .*: *:.*:**.**. *: Mb1689|M.bovis_AF2122/97 TPAMFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRL Rv1661|M.tuberculosis_H37Rv TPAMFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRL MAV_3109|M.avium_104 TPAMFIEFSRQRALAADGRCKAYAGAADGTGFSEGVGVLVLERLSDARRL MMAR_0102|M.marinum_M TPATFVGFSRQRGLAADGRCKAFAGAADGTGFSEGAGVVVLMRLSEARRR MLBr_00135|M.leprae_Br4923 LPSIFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRL MUL_2005|M.ulcerans_Agy99 LPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRN Mflv_0405|M.gilvum_PYR-GCK SPVTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAVRD MAB_0939|M.abscessus_ATCC_1997 SPVTVIAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAERD MSMEG_0408|M.smegmatis_MC2_155 SPVTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRD Mvan_1003|M.vanbaalenii_PYR-1 SPATTIATSRARMLSPDGRCKTFDAAADGYVRGEGCGILVLKRLSDAVRD TH_4621|M.thermoresistible__bu EPRKYTSASGLGMLSPTGRCHAFDVAADGFVRSEGSVMLLLKRLPDALRD * * *:. ***::: :*** .** :::* **.:* * Mb1689|M.bovis_AF2122/97 GHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDV Rv1661|M.tuberculosis_H37Rv GHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDV MAV_3109|M.avium_104 GHSVLAVLRGSAVNQDGASNGLATPNGPSQQRVIRAALANARLGAADVDL MMAR_0102|M.marinum_M GLAVLGVIAGSAVNQDGASNGLTAPNGPAQQRVIEAALANAGLTAADVDV MLBr_00135|M.leprae_Br4923 GHTVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDV MUL_2005|M.ulcerans_Agy99 GHNVLAVVRGSAINQDGASNGLTAPNGLTQQRVIQAALANCGLTSADVDV Mflv_0405|M.gilvum_PYR-GCK GDRVCAVIAGSAVNQDGASSGLTVPNGGAQQRLIGTVLARAGITGGEVDY MAB_0939|M.abscessus_ATCC_1997 GDRVLAVIPGSAVNQDGASSGLTVPNGGAQQRLIGSVLARAGLVGGDVDY MSMEG_0408|M.smegmatis_MC2_155 GDRVCAVIPASSVNQDGASSGLTVPNGGAQQRLIEATLARAGLSGADVDY Mvan_1003|M.vanbaalenii_PYR-1 GDRIQAVIRGSAVNQDGASGGLTVPNGGAQQRVIAAALTRAGLSGSDIDY TH_4621|M.thermoresistible__bu NDRILAVVRGTAANQDGRTENISTPSIQAQADVYRSALAVAGVDPATVGM . : .:: .:: **** : .::.*. :* : :.*: . : . :. Mb1689|M.bovis_AF2122/97 VEGHGTGTTLGDPIEAQAILATYGQ-RPADRPLWLGSIKSNIGHTSAAAG Rv1661|M.tuberculosis_H37Rv VEGHGTGTTLGDPIEAQAILATYGQ-RPADRPLWLGSIKSNIGHTSAAAG MAV_3109|M.avium_104 VEGHGTGTMLGDPIEAQALLATYGQDRPVDEPLWLGSIKSNMGHTSAAAG MMAR_0102|M.marinum_M VEGHGTGTTLGDPIEAQALLATYGQARPADRPLWLGSIKSNMGHTQAAAG MLBr_00135|M.leprae_Br4923 VEAHGTATTLGDPIEAQALLATYGQGRPADQPLWVGSIKSNMGHTQAAAG MUL_2005|M.ulcerans_Agy99 VEAHGTATTLGDPIEAEALLATYGQGRPTDQPLWVGSIKSNMGHTQAAAG Mflv_0405|M.gilvum_PYR-GCK LEAHGTGTPLGDPIEVQAAAAAYAGARDADRPLLMGSVKTNIGHTESASG MAB_0939|M.abscessus_ATCC_1997 LEAHGTGTPLGDPIEVQAAAAAYGGSRDADRPLLMGSVKSNIGHTESASG MSMEG_0408|M.smegmatis_MC2_155 LEAHGTGTPLGDPIEVQAAAAAYGAGRDADRPLLMGSVKTNIGHTESASG Mvan_1003|M.vanbaalenii_PYR-1 LEAHGTGTSLGDPIEVQAAGAVLGAGRDPDRPLLMGSVKTNVGHLESASG TH_4621|M.thermoresistible__bu VEAHGTGTPVGDPIEYNSLTQVYGKTGPCA----LTSVKTNFGHAESAAG :*.***.* :***** :: . . : *:*:*.** .:*:* Mb1689|M.bovis_AF2122/97 VAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVP-G Rv1661|M.tuberculosis_H37Rv VAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVP-G MAV_3109|M.avium_104 AGGVIKMVQAIRHGVMPKTLHVDEPTPQVDWSAGAVSLLTEARPWPAR-D MMAR_0102|M.marinum_M IAGVIKMVQAMRHELMPATLHVDVPSPHVDWSSGAVSLLTQPRPWPAVDG MLBr_00135|M.leprae_Br4923 VAGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSVE-G MUL_2005|M.ulcerans_Agy99 VAGVIKMVQAMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWPDA-G Mflv_0405|M.gilvum_PYR-GCK AAGLIKVVLSLQHETLPQSLHFDTPSPHIPWDSLPVRVVDTAMPWQPN-G MAB_0939|M.abscessus_ATCC_1997 AAGLIKVVLSLQNGVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQAN-G MSMEG_0408|M.smegmatis_MC2_155 AAGLIKVVLSLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQTN-G Mvan_1003|M.vanbaalenii_PYR-1 VAGLIKVVLSLQHEMLPRHLHFKTPSPHIPWDRLAVRVVAEPTPWRAD-G TH_4621|M.thermoresistible__bu ALGMMKAILALQHGVVPQNLHFTRLPDEMAAIETNLFVPQATTLWPVREG *::* : :::: :* **. . .: : : . * . Mb1689|M.bovis_AF2122/97 RPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGN-------------- Rv1661|M.tuberculosis_H37Rv RPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGN-------------- MAV_3109|M.avium_104 RPRRAGVSSFGISGTNAHVIVEQY---EPETVAPQG-------------- MMAR_0102|M.marinum_M RPRRAGVSSFGISGTNAHVIVEQVCP-EVVAEAVDV-------------- MLBr_00135|M.leprae_Br4923 RPRRAGVSSFGISGTNAHVILEEAPTPVEASYSTAD------------QQ MUL_2005|M.ulcerans_Agy99 RPRRAGVSSFGISGTNAHVILEEAPAPEAVPDSESNK----------GEP Mflv_0405|M.gilvum_PYR-GCK RPRRAGVSSFGFTGTNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPA MAB_0939|M.abscessus_ATCC_1997 RPRRAGVSSFGFTGTNAHVLIEEAPQPQATP----------DEDDASTPQ MSMEG_0408|M.smegmatis_MC2_155 RVRRAGVSSFGFTGTNAHVLVEEAPPQLHTADAAP----VEPAATAEAGT Mvan_1003|M.vanbaalenii_PYR-1 RPRRAGVSSFGFSGTNAHVVLEEPPAQSADLRQPPTDGKDGAAGLESATA TH_4621|M.thermoresistible__bu CPRRAAVSSYGMSGTNVHAVLEQAPEPVQRPEESADT------------D ***.***:*::***.*.::*: Mb1689|M.bovis_AF2122/97 DPVAVPWVLSARSAQALTNQARRLLAWVGAD-ENVRPLDVGWSLVNTRSL Rv1661|M.tuberculosis_H37Rv DPVAVPWVLSARSAQALTNQARRLLAWVGAD-ENVRPLDVGWSLVNTRSL MAV_3109|M.avium_104 GDVVVPWVLSARSAEALTNQAARLLARVKAD-PGVRVLDVGWSLVSTRSR MMAR_0102|M.marinum_M SPDSLPWVVSGKSEAAVAAQAKRLLAAVQAD-EGLDRLDVGFSLAR-RTA MLBr_00135|M.leprae_Br4923 RLSVVPWVVSGRSTAALMAQASRLAFYVQAD-PEVDPVDVGCALAA-RSV MUL_2005|M.ulcerans_Agy99 SLPVVPWVISARSAEALTAQAGRLLAHVQAD-PQSNPVDIGFSLAG-RSA Mflv_0405|M.gilvum_PYR-GCK PAPVEVLPLSARSPEALVALAQRYETWLTAH-PEADLADVCRTAGTGRSH MAB_0939|M.abscessus_ATCC_1997 SAPVSVLPLSARSPEALAAVAQRYESWLAAH-PDVDLEDVCLTAGRGRSH MSMEG_0408|M.smegmatis_MC2_155 DDSPQVLALSARSPEALVELARRYDDWLSAT-PGLDIADVCHTAGVGRSH Mvan_1003|M.vanbaalenii_PYR-1 PEPAGVLPISARSPEALTALARRYESWLTAH-PDADIADVCYTAGAGRSH TH_4621|M.thermoresistible__bu AAGPLVFALSSTSAEELRRTAGRLAEWVEAHTDEVVPADLAYTLARRRAH :*. * : * * : * *: : *: Mb1689|M.bovis_AF2122/97 FDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQG Rv1661|M.tuberculosis_H37Rv FDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQG MAV_3109|M.avium_104 FEHRAVIVGADGAQLLRRLADLAGGQPGAGVVTGRAQPVGKTVFVFPGQG MMAR_0102|M.marinum_M FEYRAVVLGEDRQQLISGLTELAAGQPGPTVLNGRAATVSKTVMVFPGQG MLBr_00135|M.leprae_Br4923 FEHRAVVVGESREQLIAGLAGLAVGESGAGVAIGQAAPLGKTVVVFPGQG MUL_2005|M.ulcerans_Agy99 FEHRAVVVGADRQQLLTGLATLADGAPGAGVVTGQAGSVGKTAVVFPGQG Mflv_0405|M.gilvum_PYR-GCK FEHRAALVVDSVESARIALTDLAQNRLRPGVVRGEHLNHPTTAWMFTGQG MAB_0939|M.abscessus_ATCC_1997 FEHRAALVVDSIQTAREGLLELAQNRLRPGVVRGEHTNHPTTAWLFTGQG MSMEG_0408|M.smegmatis_MC2_155 FEYRAALVVDSVERAREGLAALAEGRTPAGVVRGEHVHRPTTAWLFTGQG Mvan_1003|M.vanbaalenii_PYR-1 FEHRAALVVDSVDGARDLLAGLAEDRLGPGAVRGVCGDPPKTAWLFTGQG TH_4621|M.thermoresistible__bu RPVRTTVIADGVEALTAGLREVADGDAPYQPAVGMDDKAP--VWVFSGQG *:.:: . * :* . * . :*.*** Mb1689|M.bovis_AF2122/97 AQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPG----- Rv1661|M.tuberculosis_H37Rv AQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPG----- MAV_3109|M.avium_104 SQWPGMGAQLLDRSTVFAEHMHRCARALAEHVDWSLIDVIRGAPG----- MMAR_0102|M.marinum_M SQWPGMGRELLAASPVFAEHMRLCAEALGEFVDWSLLDVVNGVAG----- MLBr_00135|M.leprae_Br4923 AQRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGAD------ MUL_2005|M.ulcerans_Agy99 SQRIGMARELHDQLPVFAEAFDAVADELDRHLRIPLCEVMWGSD------ Mflv_0405|M.gilvum_PYR-GCK SQYPGMARELFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVP MAB_0939|M.abscessus_ATCC_1997 SQYPGMARELFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGK MSMEG_0408|M.smegmatis_MC2_155 SQYPGMARELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRET--- Mvan_1003|M.vanbaalenii_PYR-1 SQYPGMARELFDTEPVFRDTVTRCAEAIGDTLPRPLLEVLFDTDGDN--- TH_4621|M.thermoresistible__bu SQWAGMGAELLATEQVFAAKIAEIEPLVARESGFSVTEAMTASET----- :* **. :* ** . : .: :.: Mb1689|M.bovis_AF2122/97 -APGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVA Rv1661|M.tuberculosis_H37Rv -APGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVA MAV_3109|M.avium_104 -APGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAACVA MMAR_0102|M.marinum_M -APTLDRVDVVQPVLWAMMVSLAQLWRSVGVVPDAVIGHSQGEIAAACVA MLBr_00135|M.leprae_Br4923 -AGLLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVA MUL_2005|M.ulcerans_Agy99 -VALLDSTEFAQAALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVA Mflv_0405|M.gilvum_PYR-GCK PTETLRHTSFAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVA MAB_0939|M.abscessus_ATCC_1997 AGEALRHTSFAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVA MSMEG_0408|M.smegmatis_MC2_155 -ADLLQHTSFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVA Mvan_1003|M.vanbaalenii_PYR-1 -GQTLRHTSYAQPALFAIEMGLARLWQARGIEPDVVLGHSVGQYAAACVA TH_4621|M.thermoresistible__bu ----VTGIDRVQPTLFAIQVALAATMQSYGVRPGAVIGHSLGEVAAAVVA : . .*..*:*: :.* : .: *. *:*** *: :** ** Mb1689|M.bovis_AF2122/97 GALSLWDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDR-L Rv1661|M.tuberculosis_H37Rv GALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDR-L MAV_3109|M.avium_104 GALSLHDAARVVALRSRLLVRLSGRGGMVSLACGRSRAEQLIAPWGER-L MMAR_0102|M.marinum_M GALSLRDGAAVVALRSRALVDLAGTGGMVAIACGVERVRELLADYGDR-L MLBr_00135|M.leprae_Br4923 GVLAPADAAMLVVARGRLMQSMPAGGTMWAVAASE---DEVVSLLGEG-V MUL_2005|M.ulcerans_Agy99 GVLTLVDAAMLVVARGRLMQALPAGGAMVAVAAAE---DEVLPSLTDG-V Mflv_0405|M.gilvum_PYR-GCK GVFSLEDGARLMAERGRLFGSLPEGGRMVAVFADAKRVEQVAADFPR--V MAB_0939|M.abscessus_ATCC_1997 GVFSIEDGARLIAERGRLFGGLPAGGRMVAVFSDAKHVEQIAGEFPR--V MSMEG_0408|M.smegmatis_MC2_155 GVFSLDDGARLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEFPR--V Mvan_1003|M.vanbaalenii_PYR-1 GVFGLEDGARLVADRGRLFGGLPVGGRMVAVFTDAEVVEDFADEFPQ--V TH_4621|M.thermoresistible__bu GALSLEDGVKVICRRSRLCLRLAGAGAMAAIELPAQAVREFLAARGVDDV *.: *.. :: *.* : * * :: .. : Mb1689|M.bovis_AF2122/97 NIAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDA Rv1661|M.tuberculosis_H37Rv NIAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDA MAV_3109|M.avium_104 NIATVNGISAVVVSGEVDALTELLDRCAADDIRARRIDVDYASHSVQVEE MMAR_0102|M.marinum_M SLAAVNGVAAVVVSGEAKALRGLTGRCEAEGMRARRIEVDYASHSAQVES MLBr_00135|M.leprae_Br4923 GIAAINAPESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEP MUL_2005|M.ulcerans_Agy99 GIAAINAPKSVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEP Mflv_0405|M.gilvum_PYR-GCK SVGAYNGPN-TVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDP MAB_0939|M.abscessus_ATCC_1997 SVGAYNGPN-TVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDP MSMEG_0408|M.smegmatis_MC2_155 SVGAYNGPN-TVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDP Mvan_1003|M.vanbaalenii_PYR-1 SVAAYNGPN-TVLAGPASDLEQIVAGCSGEGIRTTWLDTSHAFHSALLDP TH_4621|M.thermoresistible__bu VLSVIASPESTVIGGATDTVRELVAAWEAQGVMAREVAVDVASHSPQVDP :.. . .*:.* : :. : .. * ** :: Mb1689|M.bovis_AF2122/97 IREELIAALRGIEPRTSTVAFFSTVTGELMDTAG--VNAEYWYRSIRQPV Rv1661|M.tuberculosis_H37Rv IREELIAALRGIEPRTSTVAFFSTVTGELMDTAG--VNAEYWYRSIRQPV MAV_3109|M.avium_104 IRDSLAEALRGIAPRSSAVAFFSTVTGELMDTAA--LDGDYWFRSIRQTV MMAR_0102|M.marinum_M IGSSLVEALAGVRPRSSDIEFVSTVTGASVDGAS--LGADYWYRNIRQTV MLBr_00135|M.leprae_Br4923 MLEEFVRVAAQVEVRKPQIGLVSNVTGELAGPD--FGSPQYWGEHVSRAV MUL_2005|M.ulcerans_Agy99 MLEEFARIAAQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAV Mflv_0405|M.gilvum_PYR-GCK VLDEFESYAAQLQFAAPTLPLVCNRTGAVLTGQT-SLDAQYWRRHSRQPV MAB_0939|M.abscessus_ATCC_1997 ILDEFESYAAQVQFAAPTLPLVCNRTGAVLTAQT-PIDGQYWRRHSRQPV MSMEG_0408|M.smegmatis_MC2_155 VLDEFEAYAAQFQFAAPTLPLVCNRTGAVLTGQT-PLDAQYWRRHSRQPV Mvan_1003|M.vanbaalenii_PYR-1 VLDEFESCAARLAYAAPTRPLVCNRTGAVVTGPG-VIDAQYWRRHARQPV TH_4621|M.thermoresistible__bu ILDELEEILADLQPMTPTVPYYSATSYDPREKPV--CDADYWVDNLRHEV : ..: . . . : . :** : * Mb1689|M.bovis_AF2122/97 QFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCD-RGATGEPIVIP Rv1661|M.tuberculosis_H37Rv QFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCD-RGATGEPIVIP MAV_3109|M.avium_104 QFERAVRGAAEAGYRAFIECSPHPVLTAAIEETMPDG------GQGCVIP MMAR_0102|M.marinum_M RFDRAVRYCHEQGCRTFVEASPHPVLLAGIEESLAEGIGRPDSAGVIVIP MLBr_00135|M.leprae_Br4923 RFVDSARHLQTLGATHFIESGPSSGLMGAIEQSLAPA-------EAVVVS MUL_2005|M.ulcerans_Agy99 RFADSARQLHTLGVTHFVEVGPGSGLTGSIEQSLAPA-------EAVVVS Mflv_0405|M.gilvum_PYR-GCK QFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHL-----AAPRAIA MAB_0939|M.abscessus_ATCC_1997 QFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHL-----APPRAIV MSMEG_0408|M.smegmatis_MC2_155 QFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHM-----AAPRAVA Mvan_1003|M.vanbaalenii_PYR-1 QFAESVRTLADLGCSVLMEIGPQPFLIAAALRVWPESA-----ATPRAIP TH_4621|M.thermoresistible__bu RFAAAVQAALEDGFRVFGELSPHPLLTRAVEQTARGLD-----MPVAALP :* :.: * : * .* . * . . .: Mb1689|M.bovis_AF2122/97 TLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQ Rv1661|M.tuberculosis_H37Rv TLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQ MAV_3109|M.avium_104 SLGRDDGGPDRFWLSAGQAFVSGVVVDWCAMLDGLGGRRVDLPTYGFVRQ MMAR_0102|M.marinum_M TLGRNEGGVERFWMSLSQAWLAGVGVDWSAVFAGSGGRQVGLPTYAFARR MLBr_00135|M.leprae_Br4923 MMGKDRPELASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRR MUL_2005|M.ulcerans_Agy99 MLGKDRPEVASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRR Mflv_0405|M.gilvum_PYR-GCK SLRKGVADRRQIADALAAAYIGGHKPDFAALHEQR-GVRLELPTYPFQRR MAB_0939|M.abscessus_ATCC_1997 SLRKGVEDRRQIADALASAYVSGHRPNFAALQRHP-RRTVELPTYPFQRR MSMEG_0408|M.smegmatis_MC2_155 SLRKGVADRRQIADALASAYVGGHRPDFAAVHRQP-RRPVELPTYPFQRR Mvan_1003|M.vanbaalenii_PYR-1 SLRKGPDARRQLAEAVAAAYIAGHRLDFTGHDGGP-HRRLPLPTYPFQHR TH_4621|M.thermoresistible__bu AMRREQEMPHGVRTMVGDLFAAGAAVDFAALYPSGRLVDAPLPTWTRRKL : : . . * :: . ***: : Mb1689|M.bovis_AF2122/97 RFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGG-VVLTGRISVVA Rv1661|M.tuberculosis_H37Rv RFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGG-VVLTGRISVVA MAV_3109|M.avium_104 HFWLPGGSTGSSDVAALGLRGAEHGLLGAVLPRPDSGG-VVLTGRLSTSA MMAR_0102|M.marinum_M RFWLDG-SASAADVGEAGLVAAGHALLGAVVEQPDTGA-VVLTGRLSLAR MLBr_00135|M.leprae_Br4923 RFWETPGTDGTASVSGLGLGSTEHALLGAVVERPDSGG-VVLTGRLSLAN MUL_2005|M.ulcerans_Agy99 RFWEVPGADGPADATGLGLGGAEHALLGAVVERPDSGG-VVLTGRLALAD Mflv_0405|M.gilvum_PYR-GCK RFWPKS---AGMAIDGRVGASAGSGILGSGKD-LASGD-SVYTSRLSVKT MAB_0939|M.abscessus_ATCC_1997 RFWPKS---SGTAIEG--GGGLPSGILGRGED-LASGD-SVYISRLSVRS MSMEG_0408|M.smegmatis_MC2_155 RFWPKA---SSIAVDG---GTAASGILGSGKD-LASGD-TIYTSRLSVKS Mvan_1003|M.vanbaalenii_PYR-1 SYWPKT---AGIRSDG----SSGSGLLGSAQD-LASGD-IVHTSRLSVKT TH_4621|M.thermoresistible__bu VLSREN----GEQQTRGGCTITVHPLLGTHVRLPEEPERHVWQADLGTGA :*. : . :. Mb1689|M.bovis_AF2122/97 APWLADHAVGPVVLFPGTGFVELALRAGDEVG-CSVLQELTLQAPLVLPA Rv1661|M.tuberculosis_H37Rv APWLADHAVGPVVLFPGTGFVELALRAGDEVG-CSVLQELTLQAPLVLPA MAV_3109|M.avium_104 QAWLADHAVGDTVLFPGAGFVELAIRAGDEVG-CGVIDELTLSAPLPLPA MMAR_0102|M.marinum_M QPWLADHLVGGAVLFPGTGFVELAIRAGDEVG-CGVVEELTLATPLVLNA MLBr_00135|M.leprae_Br4923 QPWLADHVIGGVVLFPGAGFVELVIRAGDEVG-CAGVEELVLAAPLVLHP MUL_2005|M.ulcerans_Agy99 QPWLADHVIGGVVLFPGAGFVELAIRAGDEVG-CAVVEELVLAAPLVLHP Mflv_0405|M.gilvum_PYR-GCK QPWLSDHVIYGTVVVPGATYAAMALAAVGTP---AHAKDVFFYEPIILPE MAB_0939|M.abscessus_ATCC_1997 QPWLSDHVIYGTVVVPGATYAAMALAAVGTP---ARAKDVFFYEPIILPE MSMEG_0408|M.smegmatis_MC2_155 QPWLADHVIYGTVVVPGATYAAMALAAVGTP---ARLKDVFFYEPIILPE Mvan_1003|M.vanbaalenii_PYR-1 QPWLSDHVIYGTVVVPGATYAAMALAAMPTP---ARVQEVFFYEPIILGD TH_4621|M.thermoresistible__bu QPWLADHQIHTVAALPGAAYCEMALAAAREVIDSDGVEVRDVRFEQMLLL .**:** : .. .**: : :.: * . . * Mb1689|M.bovis_AF2122/97 DG-VRVQVVVGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQ Rv1661|M.tuberculosis_H37Rv DG-VRVQVVVGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQ MAV_3109|M.avium_104 SGGVRLQLVVGAPDEAGRRPLSVYSAAAHQDSE--WMLHAEGVLRTGTVT MMAR_0102|M.marinum_M GTAVQVQVVVGSAGQSGQRLVSMYSRADQPDQH--WVLHAQGSVAPAAVQ MLBr_00135|M.leprae_Br4923 GSGVQVQVVVAAADESSRRAVSVYSRGDQSHGG--WLLNAEGLLEVDAAE MUL_2005|M.ulcerans_Agy99 GMGVQVQVIVGTADDSGNRALSVYSRGDKSED---WLLNAEGMLGVEAAS Mflv_0405|M.gilvum_PYR-GCK KSSREVQLTVHPSVDGE-SKFQVHSRP-YGERGAEWALNAEGVVASGVGD MAB_0939|M.abscessus_ATCC_1997 KSSREVQLTLHPLEDGSGSKFQVHSRP-YGERDVDWSLNAEGTVVTGIGD MSMEG_0408|M.smegmatis_MC2_155 KASREVQLTLHPADGGSVLSFQIHSRP-YGERGADWSLNAEGTVDTAGSD Mvan_1003|M.vanbaalenii_PYR-1 KDSREVQLMLHRTDDADGWTFEVHSRP-YGDRDADWSRNASGTVAAGVGD TH_4621|M.thermoresistible__bu DEQTEVSAVASAVEPGTLEFAVETAKDGEHERRATAVLGAADDTEPPQAH .:. . : . * . Mb1689|M.bovis_AF2122/97 -----PAA----ELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRG-LQ Rv1661|M.tuberculosis_H37Rv -----PAA----ELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRG-LQ MAV_3109|M.avium_104 -----PAG----DLSIWPPIGATAVDVTGGYARLAQRGYEYGRAFRG-LR MMAR_0102|M.marinum_M -----PAAAASAELSTWPPAGAEAVDIGGLYERLARRGYGYGPAFQG-LR MLBr_00135|M.leprae_Br4923 -----ATV----DLSLWPPEGAESVDISDAYPQLAERGYAYGPAFQG-LV MUL_2005|M.ulcerans_Agy99 -----SGA----DLSVWPPEGAESVDISDGYAQLADRGYAYGPGFQG-LV Mflv_0405|M.gilvum_PYR-GCK ---SPAAAGDLEDPVDEAIERLNRMRPQELFETFADLELAWGPTWSGSLK MAB_0939|M.abscessus_ATCC_1997 DAEPAPEAAEPAEPVDAAIERMERMRPMELFEIFADLELAWGPTWSGSLK MSMEG_0408|M.smegmatis_MC2_155 ---PDAAADEQSDPVDEVIERLERMRPQDLFETFADLELAWGPTWSGSLK Mvan_1003|M.vanbaalenii_PYR-1 -----AAPDAAADPVDNAIERLTRTRPQQLFDAFADNDLAWGPAWCSSLR TH_4621|M.thermoresistible__bu ------------DIDALLAEHPTRIEGDELRQWFDQRGVQFGPAFTGLTA : : :* : . Mb1689|M.bovis_AF2122/97 ALWRR--GAEVFADVTLP-EGVPIRG-FGIHPAVLD----AALHAWGIVE Rv1661|M.tuberculosis_H37Rv ALWRR--GAEVFADVTLP-EGVPIRG-FGIHPAVLD----AALHAWGIVE MAV_3109|M.avium_104 AMWQR--GDEIFAEVALP-DDAAAGDDFGVHPVLLD----AALHALGVAG MMAR_0102|M.marinum_M AVWRR--GRDVFAEVGLPNDDGLDLTDVGIHPALLD----AALHAWLCVG MLBr_00135|M.leprae_Br4923 AIWRR--GSELFAEVVAP--TGVVVDGMGMHPALLD----AVLHALGLAI MUL_2005|M.ulcerans_Agy99 GVWRR--DSELFAEVVAP--SGVAVDKMGMHPVVLD----AVLHALGLTA Mflv_0405|M.gilvum_PYR-GCK SLWLG--EGEAIGDILVGAELAEQLGTEPMHPVLMDLCTGVAFPAFPALL MAB_0939|M.abscessus_ATCC_1997 SLWLG--EGEAIGDVLVGEELAEQLGTEPMHPVLMDLCTGVAFPAFPALL MSMEG_0408|M.smegmatis_MC2_155 SLWLG--DGEAVGDILVGAELAEQLGSEPMHPVLMDLCTGVAFPAFPALL Mvan_1003|M.vanbaalenii_PYR-1 SLWVG--TGEAVGDIAVGAELGEHLGREPIHPVLLDLCTGIAGAALLAAA TH_4621|M.thermoresistible__bu ARIPEGTVTSVLAEVGLPGQIRSQQAPYGIHPALLD----ACFQSVAAHP . . ..:: :**.::* : Mb1689|M.bovis_AF2122/97 ----GEQQTMLPFSWQGVCLHASGAARVRVRLAPVG------RGAVPVEL Rv1661|M.tuberculosis_H37Rv ----GEQQTMLPFSWQGVCLHASGAARVRVRLAPVG------RGAVSVEL MAV_3109|M.avium_104 ----EKDQTVLPFSWQGVALHASGASRARVRIAPAG------AGAVSVEL MMAR_0102|M.marinum_M GFGGDGEATVLPFSWQHLSLHGSGASRLRVRIAPAG------PSAVSVEL MLBr_00135|M.leprae_Br4923 ENTQATTEMRLPFCWRGVSLHAGGAGRVRARFTSAG------ADAIAVDI MUL_2005|M.ulcerans_Agy99 EQNPDSDETKLPFCWRGVSLHAGGAGRVRARLTMSG------PDSISVEI Mflv_0405|M.gilvum_PYR-GCK AAEQGVNDLYLPLRYGQVSLQEKMPRRFYCRATWHEAPLDSETQVFDLEY MAB_0939|M.abscessus_ATCC_1997 AAEQGVNDLFLPLRYGQVTLKEKMPRRFYCRARWHESPLDSETQVFDLDY MSMEG_0408|M.smegmatis_MC2_155 AAEQGVNDLFLPLRYGQVTLAEKMPRRFYCRARWHRSALDSETQVFELEF Mvan_1003|M.vanbaalenii_PYR-1 AQTDADPELFLPLRYGRVEVRERMPRRFYCRARWQTGGIDSETQVFDLDF TH_4621|M.thermoresistible__bu DVQGAGSGLLLPLGVRRLQAFGPTRGARYCYARVTDAD--GSKAEADLDV **: : :: Mb1689|M.bovis_AF2122/97 ADPQGLPVLSVRQLMVRPVSAAALSR--STAGD----RGLLEMIWTPVPL Rv1661|M.tuberculosis_H37Rv ADPQGLPVLSVRQLMVRPVSAAALSR--STAGD----RGLLEMIWTPVPL MAV_3109|M.avium_104 ADGAGLPVLSVRSVTMRPVSPGQLSAAMGTAQP----SGLLDVIWSPIAL MMAR_0102|M.marinum_M ADGAGLPVLSVGSLTTRPVGAAQLQAAMSAGGDGTG-RELLNVVWTPITF MLBr_00135|M.leprae_Br4923 ADSAGLPVLTVRSLVTRAMTAEQLRTAVTAAGG-ALEQGPMDLVWSPIPL MUL_2005|M.ulcerans_Agy99 ADAAGLPVLTVGALVTRAMSAAQLRAAVAEAGGGAPDQGPLDVIWSPIPL Mflv_0405|M.gilvum_PYR-GCK LDRDGRHLGGVREFTVKRAPREALLRGLGGDAT----RLLYTLGWHEVPV MAB_0939|M.abscessus_ATCC_1997 LDRDGRHLGGIREFTVKRAPREALLRGLGGDAT----RLLYTLGWHEVAV MSMEG_0408|M.smegmatis_MC2_155 VDLGGRALGGIREFTVKRAPREALLRGLGGDAT----RLLYTLGWHEVPP Mvan_1003|M.vanbaalenii_PYR-1 LDHDGRNLGGIREFTVKRAPREALLRGLGADAT----RLIYRVGWRETSP TH_4621|M.thermoresistible__bu LDEHGNVLLRVQGLLMGGAAADGDDRDRVLGER------LLTIEWQRRDL * * : : . : * Mb1689|M.bovis_AF2122/97 E------GGDIG-------------------------------------- Rv1661|M.tuberculosis_H37Rv E------GGDIG-------------------------------------- MAV_3109|M.avium_104 G------GNDLG-------------------------------------- MMAR_0102|M.marinum_M E------RDSVQRDGERRVVSWDDFLAGRC-------------------- MLBr_00135|M.leprae_Br4923 S------SDGHGG-GLPSVVSWADYCAG---------------------- MUL_2005|M.ulcerans_Agy99 S------GSGTNGSAQPAVVSWADFCAGG--------------------- Mflv_0405|M.gilvum_PYR-GCK P----ESGDGAAPQGTWLIGGFDELAVSVPGCIPADR------------- MAB_0939|M.abscessus_ATCC_1997 PPVAGEGEESAASIGTWLIAGFDELAAKVPGCIPLNRE------------ MSMEG_0408|M.smegmatis_MC2_155 P------PSADDAVGTWLIAGFDELAAKVPGCVPIDRN------------ Mvan_1003|M.vanbaalenii_PYR-1 P---VRDDGALGPSSTWLVAGLDALADDVPGSIRIGFDRIWDPDRDGRVV TH_4621|M.thermoresistible__bu P----EADSAAGKWLLVSTSATADVSATRLSDALKQAG------------ Mb1689|M.bovis_AF2122/97 -----------------------DDAVVWELPP-HAGAQAGGDVLAAVYR Rv1661|M.tuberculosis_H37Rv -----------------------DDAVVWELPP-HAGAQAGGDVLAAVYR MAV_3109|M.avium_104 -----------------------DEVTLWEP------GEHGGDVVKSVHA MMAR_0102|M.marinum_M ---------------AAARDLDRDVAVVWQWE-----SGGAESVVNTVYT MLBr_00135|M.leprae_Br4923 -------------------RGNDTGVVVWEFGSASAGAQAPVDSVAAVYS MUL_2005|M.ulcerans_Agy99 ----------------DGGAAGDAGVVVWEP------NPAGEDVVGPVYA Mflv_0405|M.gilvum_PYR-GCK ---TNPESLRQLLTDAHGRGLPFSGVVWRAARSDGDES--DAEVAARLEA MAB_0939|M.abscessus_ATCC_1997 ---TDPELLGEVLVAAKERGVPFSGVVWRAAGPGATES--TTESAARLEG MSMEG_0408|M.smegmatis_MC2_155 ---TDLQVLGEVLSQAHARGAGFSGVVWRCATPGRKESGSASAESARLEA Mvan_1003|M.vanbaalenii_PYR-1 LDPADDEHWRRLFALADERRAPVAGVVLGVTGRARPEE-PSADFAARLEA TH_4621|M.thermoresistible__bu -AESTSMCWPQQADHADNVDRFRAGIADGVTGVVVLTGPKNGNPDDAAAR . Mb1689|M.bovis_AF2122/97 GVHEVLEVLQSWLA-----SDATGLGVVVTRGAVGPVDDDVTDLAGAAVW Rv1661|M.tuberculosis_H37Rv GVHEVLEVLQSWLA-----SDATGLGVVVTRGAVGPVDDDVTDLAGAAVW MAV_3109|M.avium_104 AVTETLAVLQSWLD-----GEGAGVLAVQTHGAVALAGEDVSDLAGAAVW MMAR_0102|M.marinum_M ATHRVLEVLQRWLA-----DDLPAVLVVCTRGAMGLAGEAITDLAGAAVW MLBr_00135|M.leprae_Br4923 ATHAALQVLQFWFG-----QDRAGTLVVLTRGAVGLVGEGISDLAAAAVW MUL_2005|M.ulcerans_Agy99 ATHAALEVLQSWFD-----GDRAGTLVVLTHGAVAMPGENVSDLAGAAVW Mflv_0405|M.gilvum_PYR-GCK EIAELLGAVHTVQ---GGEVKLPGGLWIVTERAVATESGEPVDPVQAALW MAB_0939|M.abscessus_ATCC_1997 EIAHLLSAVHTVQNSAQNGVKLPGGLWIVTERAVATESGEPVDPVQAALW MSMEG_0408|M.smegmatis_MC2_155 EITNLLSAVHAAQ---GPSVKLPGGLWIVTEHGVACESGEPVDPVQAALW Mvan_1003|M.vanbaalenii_PYR-1 QIRDVLGAVHSLS---ALGAKPAAGLWIVTERAVAAEAGEPVDPVQSALW TH_4621|M.thermoresistible__bu RGSDYVRHLVRITRELAEIDGDAPRLFVVTRGAQAVLPQDRPNLEQAGLR : : . : *. . . : :.: Mb1689|M.bovis_AF2122/97 GLVRSAQAEHP-GRVVLVDTDGS-VAVEDAVGFGARS--GEPQLVVRRG- Rv1661|M.tuberculosis_H37Rv GLVRSAQAEHP-GRVVLVDTDGS-VAVEDAVGFGARS--GEPQLVVRRG- MAV_3109|M.avium_104 GLVRSAQAEHP-GRLVLIDSDGS-LDARAVIPC------GEPQVVVRQG- MMAR_0102|M.marinum_M GLVRSAQTEHP-GRIVLIDTDTS-MALPTVIGV------GEPQLVVRAG- MLBr_00135|M.leprae_Br4923 GMVRSAQSEHS-GKIVLIDTDSA-VDVAVLADL------GESQLLVRCN- MUL_2005|M.ulcerans_Agy99 GIVRSAQAENP-GRIVLVDADAA-VEAAELVAV------GEPQLVVRSG- Mflv_0405|M.gilvum_PYR-GCK GFGRTAINEEPALRCRLVDCDGSPQAVQALAALLSTP-VDEPELAVRQG- MAB_0939|M.abscessus_ATCC_1997 GFGRTTINEEPALRAKLVDGDGSPEAVQALARLLVTP-VDEPEIAVRQG- MSMEG_0408|M.smegmatis_MC2_155 GFGRTTINEEPALHCRLVDCDGSSEAVDLLAALLAAPGIQEPEIAVRQG- Mvan_1003|M.vanbaalenii_PYR-1 GLGRTLIAEEPGLRCLLVDLDGSEDAGPALARLLGAP-GDEPELALRQG- TH_4621|M.thermoresistible__bu GLLRVIGAEHPHLRTTQIDIADDADLDRVAVQLLGGG--AEDETAWRDGQ *: * *.. : :* * : * . Mb1689|M.bovis_AF2122/97 ----RVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPVAP-- Rv1661|M.tuberculosis_H37Rv ----RVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPVAP-- MAV_3109|M.avium_104 ----VAHAARLRPARAGATLG-LPSGAWRLDAGGEGTLGDLVVSRCPR-- MMAR_0102|M.marinum_M ----DVYAARLARGRAALRTPDAGQG-WQLAATGGGTFDDVVLEPCPRSD MLBr_00135|M.leprae_Br4923 ----TVHAARLSPAPQLLALP-VGESMWRLAADGGGTLEDLVIQPCPEVQ MUL_2005|M.ulcerans_Agy99 ----AAHAARLAPAAPLLAVP-ADESAWRLAAGGGGTLEDLVIEPCPEVQ Mflv_0405|M.gilvum_PYR-GCK ----KLLASRLLPWSRSGHLTVPRGGDYVLAPTERGAIDNLRLTDSEVP- MAB_0939|M.abscessus_ATCC_1997 ----KLLASRLLPWSRTGHLTVPRGSDYVLAPTERGAIDNLRITEKEVP- MSMEG_0408|M.smegmatis_MC2_155 ----KLLASRLLPWARSGHLTLPRGGDFVLAPTERGAIDNLRLTETDVP- Mvan_1003|M.vanbaalenii_PYR-1 ----RLLVPRLLPWSRSGQLAIPRGTDYVLAPTERGVLDNLRVSETEVT- TH_4621|M.thermoresistible__bu WYTARLSLSPLRPEERKQAVVDCERDGMRLEIRTPGDLETMELAAFDR-- . * * * : : : Mb1689|M.bovis_AF2122/97 VELATGQVRVAVGAVGVNFRDVLVALGMYP---GGG-ELGVDGAGVVVEV Rv1661|M.tuberculosis_H37Rv VELATGQVRVAVGAVGVNFRDVLVALGMYP---GGG-ELGVDGAGVVVEV MAV_3109|M.avium_104 TELADGQVRVAVAAVGVNFRDVLVALGMYP---GGG-RLGAEGAGVVVEV MMAR_0102|M.marinum_M EPLAVGQVRVALAALGVNFRDVLVVLGLYP---GNKPTLGGEGAGVVVEV MLBr_00135|M.leprae_Br4923 APLQAGHMRVAVAAVGVNFRDVVAALGMYP---GQAPPLGAEGAGVVIEI MUL_2005|M.ulcerans_Agy99 APLAAGQVRVAVRAVGVNFRDVVAALGMYP---GAAPPLGAEGAGVVLEV Mflv_0405|M.gilvum_PYR-GCK -PPAEGYVQVRVEAAGLNFRDVLNVLGLYP---GDPGPIGGDFAGTVTQL MAB_0939|M.abscessus_ATCC_1997 -APDEGYVQVRVEAAGLNFRDVLNVLGLYP---GDPGPIGGDFAGIVTQL MSMEG_0408|M.smegmatis_MC2_155 -EPDEGYVQVRVEAAGLNFRDVLNVLGLYP---GDPGPIGGDFAGTVTQL Mvan_1003|M.vanbaalenii_PYR-1 -APPEGHVQVRVEAAGLNFRDVLNALGLYP---GDPGPIGGELAGVVTAP TH_4621|M.thermoresistible__bu VPPGPGQIEVAVTASSINFADVLIAFGRYPTFDGRRPQLGTDFAGVVTAV * :.* : * .:** **: .:* ** * :* : ** * Mb1689|M.bovis_AF2122/97 GPGVTGLAVGDRVMG--LLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPV Rv1661|M.tuberculosis_H37Rv GPGVTGLAVGDRVMG--LLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPV MAV_3109|M.avium_104 GPAVTGLAVGDPVMG--LLGVVGSEAVVDQRLLTAVPPGLSLVAAAGVPV MMAR_0102|M.marinum_M GPGVSGLEPGDRVLG--LMSGR-SECVVDQRLLVPIPAGWSFAEAASAPI MLBr_00135|M.leprae_Br4923 GPEVTGVAVGDAVMG--FLGGAGPLAVVHQQLITQMPQGWSLAEAAAVPV MUL_2005|M.ulcerans_Agy99 GPQVSGVAVGDSVMG--FLGGAGPLSVVDQQLITRMPQGWSFAQAAAVPV Mflv_0405|M.gilvum_PYR-GCK GEGVTGLDVGQRVYGS-MQGAFASRFNVPGQFLAPIPDGVSAVEAATIPA MAB_0939|M.abscessus_ATCC_1997 GEGVTGVEVGQRVYGS-MQGAFGSRFNVPAQFLAPIPDGISGVEAATIPA MSMEG_0408|M.smegmatis_MC2_155 GAGVSGLEIGQRVYGS-MQGAFASRFNVPAQFLAPIPDGIGAVEAATIPA Mvan_1003|M.vanbaalenii_PYR-1 GPDVDGFDVGQRVFGF-AVGAFASRVNVPVQFLAPVPEGISAVAAATTPA TH_4621|M.thermoresistible__bu GPDVTSHRVGDRVGGLSPNGCWSTFVTCDADLAVPLPDGLTEGQAAAVST * * . *: * * . . : . :* * ** . Mb1689|M.bovis_AF2122/97 AFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTAS Rv1661|M.tuberculosis_H37Rv AFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTAS MAV_3109|M.avium_104 VFLTALYGLSVLSGLRPGERVLVHTATGGVGMAAVQLARHYGAEVFATAS MMAR_0102|M.marinum_M VFLTAFYGLSDLAGLRRGESVLVHAATGGVGMAAIQLARLWGARVFVTAS MLBr_00135|M.leprae_Br4923 VFLTALFGLADLAGIRAGESVLIHAGTGGVGMAAVQFARHWGVEIFVTAS MUL_2005|M.ulcerans_Agy99 VFLTALFGLQDLAKIQPGESVLIHAGTGGVGMAAVQLARHWGVEIFVTAS Mflv_0405|M.gilvum_PYR-GCK AALTVRLSF-DWAQVKSGDKVLIHAASGGVGLAAVQMAQQCGAEVYATAS MAB_0939|M.abscessus_ATCC_1997 AALTVRLSF-DWAQLKPGDKVLIHAASGGVGLAAIQMAQQFGAEVFATAS MSMEG_0408|M.smegmatis_MC2_155 AALTVRLAF-DWAQLKPGDKVLIHAASGGVGLAAIQMAQQSGAEVFATAS Mvan_1003|M.vanbaalenii_PYR-1 AVLTAGLAF-DWAALRAGDRVLIHAASGGVGLAAVQLARQRGATVFATAS TH_4621|M.thermoresistible__bu AHATAWYGLHDLARLGAGEKVLIHSATGGVGLAAIAIARSVGAQIYATAG . *. .: : : *: **:*:.:****:**: :*: *. ::.**. Mb1689|M.bovis_AF2122/97 R-AKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGE- Rv1661|M.tuberculosis_H37Rv R-AKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGE- MAV_3109|M.avium_104 R-GKWDTLRAMGFDDDHIGDSRSPDFEQKFLAATGGAGVDVVLNSLAGE- MMAR_0102|M.marinum_M R-GKWDTLRAMGFDDDQIADSRTLEFEEKFSAATGGRGIDVVLNALAGE- MLBr_00135|M.leprae_Br4923 R-GKWDTLRDMGFDDDHIGDSRTLEFEEKFLAVTDGRGVDVVLDSLAGD- MUL_2005|M.ulcerans_Agy99 R-GKWDTLRAMGFDDDHIGDSRTLDFEEKFLAVTDGRGVDVVLDSLAGD- Mflv_0405|M.gilvum_PYR-GCK T-FKRATLRKLGVK--HVYDSRTTDFAEQILADTDGAGVDVVLNSLTSEG MAB_0939|M.abscessus_ATCC_1997 T-FKRATLRKLGVK--YVYDSRTTDFADQILADTDGAGVDVVLNSLTSEG MSMEG_0408|M.smegmatis_MC2_155 T-FKRSTLRRLGVK--YVYDSRTTDFADQILADTNGAGVDVVLNSLTSAG Mvan_1003|M.vanbaalenii_PYR-1 G-YKRPMLRAMGVD--HVYDSRTTDFADQILADTDGAGVDVVLNSLTNDG TH_4621|M.thermoresistible__bu SPARRDLLRDMGIE--HVYDSRSTAFADEIRRDTDGYGVDVVLNSLPGA- : ** :*.. : ***: * : : * * *:****::*.. Mb1689|M.bovis_AF2122/97 FTDASLRLLPSGGRFIELGKTDIRDGQTVAER--HRGVRYR--AFDLV-E Rv1661|M.tuberculosis_H37Rv FTDASLRLLPSGGRFIELGKTDIRDGQTVAER--HRGVRYR--AFDLV-E MAV_3109|M.avium_104 FTDASLRLLAPGGRFIEMGKTDVRDPDVVAQR--YRGARYR--AFDLM-E MMAR_0102|M.marinum_M FTDASLRLLAERGRFIEMGKTDIRDAQEVAQE--HPGVSYR--AFDLANE MLBr_00135|M.leprae_Br4923 FVDASLRLLVRGGRFLEMGKTDIRDAQEIAAN--YPGVQYR--AFDLS-E MUL_2005|M.ulcerans_Agy99 FVDASLRLLVRGGRFLEMGKTDIRDADKIAAN--YPGVWYR--AFDLS-E Mflv_0405|M.gilvum_PYR-GCK FIEATLRATAQHGRFAEIAKRDIWTVEQMAAA--RPDLAYEIVALDTVMF MAB_0939|M.abscessus_ATCC_1997 FIEATLRATAKNGRFAEIAKRDIWTTEQMAQS--RPDIAYEIVALDTVMF MSMEG_0408|M.smegmatis_MC2_155 FVEATLKATAQGGRFAEIAKRDIWSHEQMAEA--RPDIAYEIVALDTVMF Mvan_1003|M.vanbaalenii_PYR-1 FVAATVRATARNGRFAEIAKRDIWSPEQMAAA--RPDIDYEVLALDAVMQ TH_4621|M.thermoresistible__bu AQRAGLELLSFGGRFIEIGKRDIYGDTRLGLFPFRRNLAFHGVDLGLMAD * :. *** *:.* *: :. . :. :. Mb1689|M.bovis_AF2122/97 AGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK Rv1661|M.tuberculosis_H37Rv AGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK MAV_3109|M.avium_104 AGPDRTAAMLAEIVGLLRAGVLTPLPLKTFDVRCASTAYRYVSQARHIGK MMAR_0102|M.marinum_M VAPQRLGQMLAELMTLFAAGKLHRLPVKTWDVRCAPQAYQFVSQARHIGK MLBr_00135|M.leprae_Br4923 AGPVRMQEMLCEVRELFDTQVLHRLPVTSWDVRCAPAAFRFMSQARHIGK MUL_2005|M.ulcerans_Agy99 AGPVRMQEMLAEVRELFDTAVLHRLPVTTWDVRCAPAAFRFMSQARHIGK Mflv_0405|M.gilvum_PYR-GCK TEPDRIRDLLTEVSAGLRDGAWTPLPAEVYPLTEARAAFRRMQQARHIGK MAB_0939|M.abscessus_ATCC_1997 QEPDRIRVLLTEVSEGLAKGEWTPLPAEIYPLTEARTAFRRMQQARHIGK MSMEG_0408|M.smegmatis_MC2_155 TEPDRIRDLLTEVSDGMARGEWTPLPAEIYPITEARSAFRRMQQARHIGK Mvan_1003|M.vanbaalenii_PYR-1 QDPDRIQLLLADLADSLARGETAPLPFEAYPLAEATTAFRRMQQARHTGK TH_4621|M.thermoresistible__bu SHPHKIRELLETVYRLTADGVLPMPQSTHYPLAEAATAIRVMSAAEHVGK * : :* : : * * : :. *.* ** Mb1689|M.bovis_AF2122/97 VVLTIPDGPG-----GQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVAN Rv1661|M.tuberculosis_H37Rv VVLTIPDGPG-----GQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVAN MAV_3109|M.avium_104 VVLTVPSGPGEVLSGCGGGLAQSTVLITGGTGMAGSALARHLVDRYRVGH MMAR_0102|M.marinum_M VVLSAPTELR-------DALAAGTVLITGGTGLVGSVLARHLVSAYGVRN MLBr_00135|M.leprae_Br4923 VVLTMPSALA-------DGLAEGTVLITGASGAIGGVLARHMVSAYGVRH MUL_2005|M.ulcerans_Agy99 VVLTMPSALA-------DGLADATVLITGATGAVGAVLARHMLDGYGVRH Mflv_0405|M.gilvum_PYR-GCK IVVQIPNPLQ--------PQPDRSYLITGGLGAIGLHTAGYLAQ-LGAGD MAB_0939|M.abscessus_ATCC_1997 IVCQMPNPLA--------PRPDRTYLITGGLGAIGLHTAAYLAQ-LGAGD MSMEG_0408|M.smegmatis_MC2_155 IVLQVPKPLQ--------PQQDRSYLITGGLGAIGLHTAAYLAQ-LGAGD Mvan_1003|M.vanbaalenii_PYR-1 IILQMPKPLQ--------PHGDRSYLITGGLGALGLHAAAYLAQ-LGAGD TH_4621|M.thermoresistible__bu LVLDVPHTGR-----------ADVVVPPEQASPFRSDGAYIVTGGMGGLG :: * : . . * : Mb1689|M.bovis_AF2122/97 LVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDP Rv1661|M.tuberculosis_H37Rv LVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDP MAV_3109|M.avium_104 VVLVSRTGAQAAGAAELVDELQRAGASASVLACDVGDRDAVATMLAGLPS MMAR_0102|M.marinum_M LVLVSRMGEQGAGVAELVDELSDAGARVLVAACDVADQSAVEKLIAGWGR MLBr_00135|M.leprae_Br4923 LVLASRRGDRAEGAVELAAELVGAGAKIQVVACDVADNDAVRGLFAQLSR MUL_2005|M.ulcerans_Agy99 LVLASRRGDRAEGAAELAAELSEAGANVQVVACDVADRDAVEAMLARLSG Mflv_0405|M.gilvum_PYR-GCK IVLTSRRAPDAAAQQAIADIADRTKARLHVFTADVGVEADVAALLERIRA MAB_0939|M.abscessus_ATCC_1997 IVLTSRRAPDTDAQRVIGEITERSKTRIHVFTADVGAESEVAGLLERIRA MSMEG_0408|M.smegmatis_MC2_155 IVLTSRRDPDESAQRAIDEITERHKCRIHTYAADVGDEAQVADLLARIRA Mvan_1003|M.vanbaalenii_PYR-1 IVLTGRRMPDAATERAISEIAERYHCRIHTFAADVGDESAVRDLLERIRT TH_4621|M.thermoresistible__bu LYLAGEMAAAGAGCIVLNGRSAPSGEALRTIEQLRAAGTEVIVECGXX-- : *... : . . : Mb1689|M.bovis_AF2122/97 RYP-LKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMD Rv1661|M.tuberculosis_H37Rv RYP-LKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMD MAV_3109|M.avium_104 GYP-LRGIVHAAGILDDGLLSSLTPDRVDAVLRAKVDGAWNLHELTKDLD MMAR_0102|M.marinum_M EYPALTGVIHAAGVLDDAVITSMTPDQVDSVLRAKVDGAWNLHHATRGLG MLBr_00135|M.leprae_Br4923 EFPPVRGVIHAAGVLDDGAITSLTPDRVDTVLRAKVDAAWNLHEATRDLD MUL_2005|M.ulcerans_Agy99 EYPPVRGVIHAAGVLDDAVISSLTPERIDTVLRAKVDAAWNLHEATLDLD Mflv_0405|M.gilvum_PYR-GCK ELPPLAGVAHLAGVLDDALLSQQSVERFRTALAPKAFGAVHLDRLTRVDD MAB_0939|M.abscessus_ATCC_1997 ELPPLAGVAHLAGVLDDALLGQQSVERFRTTLAPKAFGAEYLDRLTKGDD MSMEG_0408|M.smegmatis_MC2_155 ELPPLAGIAHLAGVLDDALLSAQNPERFRTTLAPKAYGASHLDRLTRDDD Mvan_1003|M.vanbaalenii_PYR-1 ELPPLAGVAHLAGVLDDALLPQQSPERFRTTLAPKAFGAWHLHRLTRDTE TH_4621|M.thermoresistible__bu ----XRGQPVEVAVPTELRHADEHPDRRG--------------------- * ..: : :: Mb1689|M.bovis_AF2122/97 LSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGL Rv1661|M.tuberculosis_H37Rv LSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGL MAV_3109|M.avium_104 LSAFVVFSSMAGIVGTPGQANYAAANSFLDGLVAHRRADGLAGLSLAWGL MMAR_0102|M.marinum_M LSMFVLCSSIAGVVGAPGQGNYAAANAFLDALVTDRRAHGLAGVSLGWGL MLBr_00135|M.leprae_Br4923 LLMFVLCSSIAATVGSPGQGNYSAANAFLDGLAAYRQAAGLAGTSLAWGL MUL_2005|M.ulcerans_Agy99 LSMFVLCSSIAATVGSPGQGNYSAANSFLDGLAAHRQAAGLAGISVAWGL Mflv_0405|M.gilvum_PYR-GCK LDFFLVSSSVSSLFGSPGQSNYATANAFLDGLVAQRRAQGLPATGVNFGP MAB_0939|M.abscessus_ATCC_1997 LDFFIVSSSVSSLFGSPGQSNYATANALLDGLIAQRRAQGLPATGINFGP MSMEG_0408|M.smegmatis_MC2_155 LDFFIVSSSVSSLFGSPGQANYATANAMLDGLVAKRRAQGLVATGINFGP Mvan_1003|M.vanbaalenii_PYR-1 LEFFIVYSSGSSVLGSPGQANYATANAVLDGLVAHRKARGLPATGVNWGP TH_4621|M.thermoresistible__bu ----------AQLCDEFARGEQGAQRNQHRTDAGEGQRDAHPPGAVGHDQ : . .:.: .: . : . .: . Mb1689|M.bovis_AF2122/97 WEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA Rv1661|M.tuberculosis_H37Rv WEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA MAV_3109|M.avium_104 WEQASAMTAHLGDRDKARMSRIGLAPLSTEQALAAFDAAMLVETPVLVAA MMAR_0102|M.marinum_M WEQASGMTKHLRGSDVSRLSRGGFAAISAQQALDLFDAALIVDQPTVLAA MLBr_00135|M.leprae_Br4923 WEQPGGMNAHLSSRDLARISRSGLAPMNPAQALELFDAALVIDHPFMVTA MUL_2005|M.ulcerans_Agy99 WEQSGGMAAHLSSRDLARMSRSGLAPMNPEQAVGLLDAVLAINHPLMVAT Mflv_0405|M.gilvum_PYR-GCK WARGGMASSEAAAAN---ISAQGLIPLEPSAALTAMAEVVANGTAQATVL MAB_0939|M.abscessus_ATCC_1997 WGQGGMASSEAATAN---ISAQGLIPLDPSAALAALAEVVANGTGQATIL MSMEG_0408|M.smegmatis_MC2_155 WGQGGMASSEAATAN---ITAQGLIPLDPSAALHALAEVIANGSGQATVL Mvan_1003|M.vanbaalenii_PYR-1 WAQGGMATSDAARAN---LGAQGLIPLEPTAALNALGEIVAHGIASAVVL TH_4621|M.thermoresistible__bu PDPGALSDTGLDERGGQFPGVGVQIPVADPGVGIDHRGAVRVDSGVPAQQ . . .: . : Mb1689|M.bovis_AF2122/97 RLDRAALAG--AGAALPALFSQLAAGPTRRRIDA-ADTAVSMSGLVSRLH Rv1661|M.tuberculosis_H37Rv RLDRAALAG--AGAALPALFSQLAAGPTRRRIDA-ADTAVSMSGLVSRLH MAV_3109|M.avium_104 RLDRAALSE--NIAALPPLLRELAAGPTRRVIDD-ADVTASMSGLAARLH MMAR_0102|M.marinum_M RLDRRALENPALNADLPTLFSDLITRPMRRNVDN-DGTPTELA-LVNRLN MLBr_00135|M.leprae_Br4923 LLDRAALDAQAQAGALPPLFSRLVRRSRRRQIEDPGDATQSKLALVQRLQ MUL_2005|M.ulcerans_Agy99 LLDRPALEARAQAGGLPPLFAGVVRRPRRRQIEDTGDAAQSKSALAERLN Mflv_0405|M.gilvum_PYR-GCK KANWQRAAK-VLGSSRPPILDLVLPSAVGEITGD--------SELLKQLQ MAB_0939|M.abscessus_ATCC_1997 KANWQRAAK-VLGSSRPPILDLVLPSAVGEVTGD--------SELLKQLM MSMEG_0408|M.smegmatis_MC2_155 KANWQRAAK-VLGSARPPILDLVLPSAAGEATGD--------SELLKQLM Mvan_1003|M.vanbaalenii_PYR-1 KANWQRAAK-LLGATRPPILDHVLPSAVAAGPGD--------SALLKQLQ TH_4621|M.thermoresistible__bu GVDGEVVRHRTLSSVRSGRSSRWTAPGSRCGSGR-------------RYG : . . : Mb1689|M.bovis_AF2122/97 ALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVEL Rv1661|M.tuberculosis_H37Rv ALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVEL MAV_3109|M.avium_104 GLSPEARRRELVDLVCGNAAMVLGVPDPADINAGRAFQDLGFDSLTAVEL MMAR_0102|M.marinum_M MMNPDEQHDLLTEVVCTQAVMVLGRLNAADIDPNATFSDLGFDSLTAIEL MLBr_00135|M.leprae_Br4923 GLAANRQLELLVGVVCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAVEL MUL_2005|M.ulcerans_Agy99 GLSAGERQDALVGLVCLQAAAVLGRPSPEDIDPEAGFQDLGFDSLTAVEL Mflv_0405|M.gilvum_PYR-GCK EIPVPQRAGFVTEFLQKEVQNFLRLAQPP--AATSRFLDLGTDSLMAIEL MAB_0939|M.abscessus_ATCC_1997 EIPVPQRAGFVTEFLQREVQNFLRLAQPP--AATSRFLDLGTDSLMAIEL MSMEG_0408|M.smegmatis_MC2_155 EIPIPQRAGFVTEFLQREVQNFLRLASPP--AASSRFLDLGTDSLMAIEL Mvan_1003|M.vanbaalenii_PYR-1 DVPEAQRGSFVTEHLQRELQQILGLAQPP--AATGRFLELGMDSLMAVEL TH_4621|M.thermoresistible__bu GESCRRTTGPAAGAAARRGRTRRRRRPRRPPPPPDRVRHRAGPAHGPVRR . . . . . . : .:. Mb1689|M.bovis_AF2122/97 RNRLKTATG--LTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDR Rv1661|M.tuberculosis_H37Rv RNRLKTATG--LTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDR MAV_3109|M.avium_104 RNRLKNATG--LTLSPTLIFDYPTPVVLAEHLDSRLAGSGGDDQPDLMGR MMAR_0102|M.marinum_M RNRLKTVTG--LTLPPTLIFDHRAPSALAQHLGQQLCVTHQHESHNAMAP MLBr_00135|M.leprae_Br4923 RNRLKSATG--LTLPPTVIFDHPTPTAVAEYVAQQMLKSRPAESGDETSQ MUL_2005|M.ulcerans_Agy99 RNRFKSATG--LTLPPTVIFDHPTPTAIAEYVGRQIPDSQATQAEEE--K Mflv_0405|M.gilvum_PYR-GCK RNRLHSQFGGAFTINATAVFDYPTIGGLAEYLVAQLPDAETPQAAP---- MAB_0939|M.abscessus_ATCC_1997 RNRLHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDADAESAEAPPAV MSMEG_0408|M.smegmatis_MC2_155 RNRLHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDAEAPETA----- Mvan_1003|M.vanbaalenii_PYR-1 RNRLVGQFGSGFTITATAVFDYPTIGALAEYLAAQTPESTEEGTEMKTAD TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 VDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTSLTTED--------DD Rv1661|M.tuberculosis_H37Rv VDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTSLTTED--------DD MAV_3109|M.avium_104 FNDITRELQALLGAPHWNSDDKAVLRARIHGLLGALPAGDGPDSAPLDED MMAR_0102|M.marinum_M ADSEDEKLRSILSAISVADLRDAGLLDKLLRLRKDPDRNLRVDRVDRVDN MLBr_00135|M.leprae_Br4923 AVEPKVEEVSVHA------------------------------------- MUL_2005|M.ulcerans_Agy99 LPESDGEMVSVTA------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ---QSESEPGPDVTE----------------------------------- MAB_0939|M.abscessus_ATCC_1997 ESAEAESGAGPAAASDAVSELKE--------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 PDGQPATVGHADVVLQTS-------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mb1689|M.bovis_AF2122/97 IAAAT---ESQLFAILDEELGS---------------- Rv1661|M.tuberculosis_H37Rv IAAAT---ESQLFAILDEELGS---------------- MAV_3109|M.avium_104 LEAAT---ESQLFAILDEELGR---------------- MMAR_0102|M.marinum_M VGTKQQELEGMINSLSPEELVAMALAEPSGGNRMDSGG MLBr_00135|M.leprae_Br4923 -------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------- TH_4621|M.thermoresistible__bu --------------------------------------