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M. marinum M MMAR_2272 (-)

annotation: PE-PGRS family protein
coordinates: 2734258 - 2735727
length: 489

VSLLVVAPELVTSAAADLQGIGSSVNAANAAAAISTTELTAAAADEVSAAAATLLGGFGQQYQALAGQLA
TAYDQLASKLAADAAAYLGAESANANQLLSNAVNASTALVNGPFLELTGRPLIGNGADGYTNAQGIGTPG
GAGGWLYGNGGSGGNSTHAGVAGGAGGNAGLIGNGGMGGAGLRGGDGGTGGLGGWLWGQAGAAGTGTPLP
ANEILMRVDQYGNPVVTISVGGGPGIAVTVDTGASGLLVRPQDVNLQSLGTPTGSGAVTYGNSSYAFNTV
QYQTYQTTVNFGNGIVTNPTNVAVATSATQTINGVTTSIPLSSLPLYLGIGPNNDFPLPDQVTAALPGDL
NQGVLINTNLGYLQFGANPLTPVASVTGSPVTDLQIQINNGPLQPATGSFIDSGGLYGTIPSSLIPGVPV
GYSVPVGTTITVYTTDGVQLYSQTVTGSTNAPLVVPSNNPFNTGNYPFLLGPIYISNSPTGGGQTIFDF
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_2272--100% (489)PE-PGRS family protein
M. marinum MMMAR_1538-e-10245.22% (502) PE family protein, PE26
M. marinum MMMAR_2933-6e-9139.89% (569) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2548PE261e-10044.27% (506) PE family protein
M. gilvum PYR-GCKMflv_2178-1e-1852.22% (90) hypothetical protein Mflv_2178
M. tuberculosis H37RvRv2519PE261e-10044.47% (506) PE family protein
M. leprae Br4923MLBr_01183-9e-1543.96% (91) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_0321c-6e-1036.36% (132) hypothetical protein MAB_0321c
M. avium 104MAV_1346-2e-1429.96% (237) PE family protein
M. smegmatis MC2 155MSMEG_0868-8e-2146.03% (126) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_4332-9e-1330.90% (233) PUTATIVE -
M. ulcerans Agy99MUL_2395-2e-6441.97% (386) PE family protein
M. vanbaalenii PYR-1Mvan_0928-3e-1956.32% (87) carboxymuconolactone decarboxylase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2178|M.gilvum_PYR-GCK          -----------MSG--TAHAPGKTRLFANVTVAVGLGGAALG--AAALLA
MSMEG_0868|M.smegmatis_MC2_155      -----------MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRK
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4332|M.thermoresistible__bu      -------------MPFITSGAAFVGGAAMLLAGPGGVSALEAAGSAPRTV
Mb2548|M.bovis_AF2122/97            -------------MSRLIVAPDWLASAAAEVQSIGSALSAANAAAAAPTT
Rv2519|M.tuberculosis_H37Rv         -------------MSRLIVAPDWLASAAAEVQSIGSALSAANAAAAAPTT
MUL_2395|M.ulcerans_Agy99           -------------MAQLSVAPPWLVSAAQDLQSIGSTLAAANGAAAGPTT
MMAR_2272|M.marinum_M               -------------MSLLVVAPELVTSAAADLQGIGSSVNAANAAAAISTT
MLBr_01183|M.leprae_Br4923          ------------MPLFLNAEPQALTAAANTLEGLSAATVASNAAAAQLTT
MAV_1346|M.avium_104                ------------MS-FVTTRPEALLAVASMLEGLGSSMDAQNAAAAAPTT
Mvan_0928|M.vanbaalenii_PYR-1       MSGTQSAESDDDADDSEGDASADDAEDAEEFVGDSGNGGSDDDAADDSEK
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          P--QASAAPEEWLP----------AGPSSECPPPT-----DGCAN-----
MSMEG_0868|M.smegmatis_MC2_155      PKFPAALAPESPLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQ
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4332|M.thermoresistible__bu      EYEYSLVACDSTLP------------------------------------
Mb2548|M.bovis_AF2122/97            LLVAAAEDEVSAAA------------------------------------
Rv2519|M.tuberculosis_H37Rv         LLVAAAEDEVSAAA------------------------------------
MUL_2395|M.ulcerans_Agy99           VLATAAADEVSTAI------------------------------------
MMAR_2272|M.marinum_M               ELTAAAADEVSAAA------------------------------------
MLBr_01183|M.leprae_Br4923          EIAPPAADDVSILL------------------------------------
MAV_1346|M.avium_104                SIAPAAADEVSALQ------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       DVDSSTDDGVGDFEGVVLDDAESEADSQLSVPQPASTESTEQSADVANDA
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          -----------VAAVGGVHGAQGPANLATPQTS---GSPLFRPLFG----
MSMEG_0868|M.smegmatis_MC2_155      ATSTNTTDQPTSDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSV
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4332|M.thermoresistible__bu      ---------LMCEAGDSVGGLGGASHDRSAFSASALGMASFG--------
Mb2548|M.bovis_AF2122/97            --------------------------------------------------
Rv2519|M.tuberculosis_H37Rv         --------------------------------------------------
MUL_2395|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2272|M.marinum_M               --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       DGNADPIADAGPEAVTAPVALSGASAPAIPDGPAPVEPMGPLINSLWWAV
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          ---------NGADAPADC--------------------------------
MSMEG_0868|M.smegmatis_MC2_155      VTLGTTLIPNAPTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLP
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mb2548|M.bovis_AF2122/97            --------------------------------------------------
Rv2519|M.tuberculosis_H37Rv         --------------------------------------------------
MUL_2395|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2272|M.marinum_M               --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       PKSGGRSTNDASLTLAGTG-------------------------------
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      VPTVASAVLDPTQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQ
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mb2548|M.bovis_AF2122/97            --------------------------------------------------
Rv2519|M.tuberculosis_H37Rv         --------------------------------------------------
MUL_2395|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2272|M.marinum_M               --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          --VGNACN-------GRDGGLIWGNGGAGAN-------GGHGGNAGLVGN
MSMEG_0868|M.smegmatis_MC2_155      YLIGNGINGTADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFGN
MAB_0321c|M.abscessus_ATCC_199      -------------------------------------------MANIISN
TH_4332|M.thermoresistible__bu      ---PDWNPGGAFLGLIGPGGLLIGDG-------------LNGTDAYIDEN
Mb2548|M.bovis_AF2122/97            -------------------------------------------AALFANY
Rv2519|M.tuberculosis_H37Rv         -------------------------------------------AALFANY
MUL_2395|M.ulcerans_Agy99           -------------------------------------------AALFAGH
MMAR_2272|M.marinum_M               -------------------------------------------ATLLGGF
MLBr_01183|M.leprae_Br4923          -------------------------------------------AHFFSGH
MAV_1346|M.avium_104                -------------------------------------------AAQFSAY
Mvan_0928|M.vanbaalenii_PYR-1       ----------IYPSVTSLFAFGGRCGLICDGADGTEQNPNGVGGGWLFGD
                                                                                  :   

Mflv_2178|M.gilvum_PYR-GCK          GGRGGD----------------------------------ATTPGRSGGH
MSMEG_0868|M.smegmatis_MC2_155      GGNGGVGWAGLDGGNGGSGGLLMGIGGAGGAGGVGADGTSAHVDGGTGGT
MAB_0321c|M.abscessus_ATCC_199      G-----------------------------------------PDGDAGAT
TH_4332|M.thermoresistible__bu      G---------------------------------------VFHEATRGGN
Mb2548|M.bovis_AF2122/97            G---------------------------------------REYQTLSVRF
Rv2519|M.tuberculosis_H37Rv         G---------------------------------------REYQTLSVRF
MUL_2395|M.ulcerans_Agy99           A---------------------------------------REYHSLSGHF
MMAR_2272|M.marinum_M               G---------------------------------------QQYQALAGQL
MLBr_01183|M.leprae_Br4923          G---------------------------------------RQYQAHASQG
MAV_1346|M.avium_104                G---------------------------------------TWYQQVSAQA
Mvan_0928|M.vanbaalenii_PYR-1       GGDGWS----------------------------------STLAGIAGGK
                                    .                                                 

Mflv_2178|M.gilvum_PYR-GCK          GGNGG----------------------------RLWGNGGDGGNGAPGVL
MSMEG_0868|M.smegmatis_MC2_155      GGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYV
MAB_0321c|M.abscessus_ATCC_199      G-----------------------------------AQGSQGATGAAGAM
TH_4332|M.thermoresistible__bu      GG-------------------------------LLWGNGGKGGNGLDAGL
Mb2548|M.bovis_AF2122/97            ASLDQ-----------------------------QFAQALNSAAASYQTA
Rv2519|M.tuberculosis_H37Rv         ASLDQ-----------------------------QFAQALNSAAASYQTA
MUL_2395|M.ulcerans_Agy99           GAFNQ-----------------------------QFVQALNSASGAYASA
MMAR_2272|M.marinum_M               ATAYD-----------------------------QLASKLAADAAAYLGA
MLBr_01183|M.leprae_Br4923          ATNHQ-----------------------------DLIQSLLTSSSAYAGT
MAV_1346|M.avium_104                KAIHQ-----------------------------TLVQNLDTNADSYGAT
Mvan_0928|M.vanbaalenii_PYR-1       GGAAG----------------------------LLWGSGGDGGAGGAGAA
                                                                         .            

Mflv_2178|M.gilvum_PYR-GCK          GPAGTAPIPPSSLPAATG----TRGDSPPYG-------------------
MSMEG_0868|M.smegmatis_MC2_155      LIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGA
MAB_0321c|M.abscessus_ATCC_199      ANCN-WIDDDCATRGGTG--------------------------------
TH_4332|M.thermoresistible__bu      YTVPDPDNPGSTIQMYFEAS------------------------------
Mb2548|M.bovis_AF2122/97            EATGAS-LVQTATQGVLGVINAPTEFMFGRS-------------------
Rv2519|M.tuberculosis_H37Rv         EATGAS-LVQTATQGVLGVINAPTEFMFGRS-------------------
MUL_2395|M.ulcerans_Agy99           EAQSAS-LLQTVGRDVLGAINAPTEFLLGRP-------------------
MMAR_2272|M.marinum_M               ESANANQLLSNAVNASTALVNGPFLELTGRP-------------------
MLBr_01183|M.leprae_Br4923          ETAN----------------------------------------------
MAV_1346|M.avium_104                EAANRVNTSAAALQGLAPNVIPNAAPAADPP-------------------
Mvan_0928|M.vanbaalenii_PYR-1       GGTGGNAGLLWGNGGHGGAGGAGVNGAVGTSG------------------
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          -----YGNLVGGDGGTGADGGRYAFGAN----------------------
MSMEG_0868|M.smegmatis_MC2_155      NGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTA
MAB_0321c|M.abscessus_ATCC_199      -----------GTGGNGGPGG-----------------------------
TH_4332|M.thermoresistible__bu      ------------DGADGGRGG-----------------------------
Mb2548|M.bovis_AF2122/97            ---------LIGDGADG-TAASPIGEPGGI----------------LYGD
Rv2519|M.tuberculosis_H37Rv         ---------LIGDGADG-TAASPIGEPGGI----------------LYGD
MUL_2395|M.ulcerans_Agy99           ---------LIGNGADG-TAANPNG-------------------------
MMAR_2272|M.marinum_M               ---------LIGNGADGYTNAQGIGTPGGAGGW-------------LYGN
MLBr_01183|M.leprae_Br4923          ------------HDSL----------------------------------
MAV_1346|M.avium_104                ---------PAGTTSLG---------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       --------VNNGRGGDGTAGGSGGAGGNAG--------------------
                                                  .                                   

Mflv_2178|M.gilvum_PYR-GCK          ------WSLDLPVGGAGGAG-----GWANSIDGSATGGNGGD--------
MSMEG_0868|M.smegmatis_MC2_155      TGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGG
MAB_0321c|M.abscessus_ATCC_199      ------------AGGPGGHG--------GVIDFEVETFMDG---------
TH_4332|M.thermoresistible__bu      --------FLFGNGGDGGNG------------GNVGGKNGADP-------
Mb2548|M.bovis_AF2122/97            GGNGYSQTTPGAVGGAGGSA------------------------------
Rv2519|M.tuberculosis_H37Rv         GGNGYSQTTPGAVGGAGGSA------------------------------
MUL_2395|M.ulcerans_Agy99           --------------GAGG--------------------------------
MMAR_2272|M.marinum_M               GGSGGNSTHAGVAGGAGGNA------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                ----------TSIGWAQNVG------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       --------LLSGRGGDGGVG------------------------------
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      AGGMGEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTT
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mb2548|M.bovis_AF2122/97            --------------------------------------------------
Rv2519|M.tuberculosis_H37Rv         --------------------------------------------------
MUL_2395|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2272|M.marinum_M               --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          ------------GGNGAFGGRGGNGG------------------------
MSMEG_0868|M.smegmatis_MC2_155      GGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGG
MAB_0321c|M.abscessus_ATCC_199      ------------VTLQAKGGRGGNGG------------------------
TH_4332|M.thermoresistible__bu      ------------VTATVAADKSVAGG------------------------
Mb2548|M.bovis_AF2122/97            ----------GFIGNGGAAGAGGPGA------------------------
Rv2519|M.tuberculosis_H37Rv         ----------GFIGNGGAGGAGGPGA------------------------
MUL_2395|M.ulcerans_Agy99           ----------LLIGNGGSGGARGPNA------------------------
MMAR_2272|M.marinum_M               ----------GLIGNGGMGGAGLRGG------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                ----------AAASDFITLGEGQFAP------------------------
Mvan_0928|M.vanbaalenii_PYR-1       -------------GAGGKGGAGAHGS------------------------
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          -------AGG------------------SAYGRGGITTGGNGGAGG----
MSMEG_0868|M.smegmatis_MC2_155      AASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWV
MAB_0321c|M.abscessus_ATCC_199      -------------------------------------HGGAGGTGG----
TH_4332|M.thermoresistible__bu      -------------------------------------NGGNGGRGG----
Mb2548|M.bovis_AF2122/97            -------------------------------------GGGTGGLGG----
Rv2519|M.tuberculosis_H37Rv         -------------------------------------GGGTGGLGG----
MUL_2395|M.ulcerans_Agy99           -------------------------------------AGGPGGLGG----
MMAR_2272|M.marinum_M               -------------------------------------DGGTGGLGG----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                -------------------------------------VPGAAGIPN----
Mvan_0928|M.vanbaalenii_PYR-1       ------------------------------DAVAAEEDGGPGGSGG----
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          ----------------------------HGSTGAAGGRGGDGA--SAS--
MSMEG_0868|M.smegmatis_MC2_155      QAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGA--GASVW
MAB_0321c|M.abscessus_ATCC_199      ----------------------------------TGGKGGDGD--DCEFG
TH_4332|M.thermoresistible__bu      ------------------------------LLFGLGGNGGNGG--WSTTS
Mb2548|M.bovis_AF2122/97            ------------------------------WLWGNNGAAGTGD--PVNV-
Rv2519|M.tuberculosis_H37Rv         ------------------------------WLWGNNGAAGTGD--PVNV-
MUL_2395|M.ulcerans_Agy99           ------------------------------WLYGNNGPAGTGS--PVNA-
MMAR_2272|M.marinum_M               ------------------------------WLWGQAGAAGTGT--PLPAN
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                ------------------------------FNPGLTAATTAGP--PAPAA
Mvan_0928|M.vanbaalenii_PYR-1       -------------------------------AGGNAGAGGVGGRGALLFG
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          --------GGYAVGGNGGDGGRGG----AGATG------------GTGGT
MSMEG_0868|M.smegmatis_MC2_155      KANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGT
MAB_0321c|M.abscessus_ATCC_199      -----------RTGGNGGTGGRGG-------------------------D
TH_4332|M.thermoresistible__bu      --------YLDARGGNGGNGGLGGVLRPGGLLS----------------L
Mb2548|M.bovis_AF2122/97            AVPLRVENN-FPLVNLLVNRGPTVPILLDTGSS------SLVIPFWKIGW
Rv2519|M.tuberculosis_H37Rv         AVPLRVENN-FPLVNLLVNRGPTVPILLDTGSS------SLVIPFWKIGW
MUL_2395|M.ulcerans_Agy99           SVPLYLDNN-FPAVNVSINGGPSVPVLLDIGSA------GLVVPIWDIGL
MMAR_2272|M.marinum_M               EILMRVDQYGNPVVTISVGGGPGIAVTVDTGAS------GLLVRPQDVNL
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                PAAAAGAPVLASMGRGPSIGGLSVPPSWAPGGV------APAANATPAQL
Mvan_0928|M.vanbaalenii_PYR-1       RGGDGGDGGSAGTGGAGGFGGTGGAIVVTLPGGKLSDSDGAGGAGGVGGA
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          GGAGGDGGRGG--LLGGHGGKG----GNAGLGGNGGTGG-----------
MSMEG_0868|M.smegmatis_MC2_155      GGHGGDGGRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHT
MAB_0321c|M.abscessus_ATCC_199      GNFAGTGGNGGAILVKCQHDLS---LGTHPMDVSAGTGG-----------
TH_4332|M.thermoresistible__bu      LLPSGAASEPGGLFTGGNGGNGGLAIANHWVGITDGVPGPDDD-------
Mb2548|M.bovis_AF2122/97            QNLGLPTGFDVVHYGNG----VSIVYADVPTTVDFGGGAATTP-------
Rv2519|M.tuberculosis_H37Rv         QNLGLPTGFDVVHYGNG----VSIVYADVPTTVDFGGGAATTP-------
MUL_2395|M.ulcerans_Agy99           QDLGLPTGFDVIRYGNG----VNILYADFNTTVDFGSGAVTAP-------
MMAR_2272|M.marinum_M               QSLGTPTGSGAVTYGNSSYAFNTVQYQTYQTTVNFGNGIVTNP-------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                VGAGFTSAAPDTAPVTA----VPGGVPSMATAGRGGYGLGAPR-------
Mvan_0928|M.vanbaalenii_PYR-1       AGLGGDGGGGGLGGLLGQAGVNGDSGATAAAGNAGGVGGAGGLGGRLPIV
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          -------------------------TGGVGGDGGVG--------------
MSMEG_0868|M.smegmatis_MC2_155      GAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGG
MAB_0321c|M.abscessus_ATCC_199      -------------------------NGGIGGGGGGG--------------
TH_4332|M.thermoresistible__bu      ----------------------AVSSSAYGGHGGHG--------------
Mb2548|M.bovis_AF2122/97            ---------------------TSVHVGILPYPRNLDS-------------
Rv2519|M.tuberculosis_H37Rv         ---------------------TSVHVGILPYPRNLDS-------------
MUL_2395|M.ulcerans_Agy99           ---------------------TSVQVGILPFPTSLQG-------------
MMAR_2272|M.marinum_M               ---------------------TNVAVATSATQTINGV-------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                ---------------------YGVKPTVMPKPAI----------------
Mvan_0928|M.vanbaalenii_PYR-1       DLNNASPAQATLAALIKKLGLPIQAATGIQLEDVDGRLVG----------
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          ------------------------GGILTATG------------------
MSMEG_0868|M.smegmatis_MC2_155      EALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANP
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mb2548|M.bovis_AF2122/97            --------------------------------------------------
Rv2519|M.tuberculosis_H37Rv         --------------------------------------------------
MUL_2395|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2272|M.marinum_M               --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       --------------------------PLNAYLYNTIIGKAIFDVGNTFSS
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          --------------------------------------VVGAGGSGG---
MSMEG_0868|M.smegmatis_MC2_155      QASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGI
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4332|M.thermoresistible__bu      -------------------------------------------------A
Mb2548|M.bovis_AF2122/97            ----------------------------------LVLIASGGAFGPNGNG
Rv2519|M.tuberculosis_H37Rv         ----------------------------------LVLIASGGAFGPNGNG
MUL_2395|M.ulcerans_Agy99           ----------------------------------LTLIAMGNGFGPTGHG
MMAR_2272|M.marinum_M               ----------------------------------TTSIPLS-----SLPL
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       ASLSARVKEIVILSVGGQWGSEYELYAHKLAAQLFGIPADAIAALANGQA
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          AGGTGGRGGD--------------------GGDGGQAG------------
MSMEG_0868|M.smegmatis_MC2_155      DGGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPS
MAB_0321c|M.abscessus_ATCC_199      -GSVGANGAT----------------------------------------
TH_4332|M.thermoresistible__bu      GPGSGGNGGS----------------------------------------
Mb2548|M.bovis_AF2122/97            ILGIGPNVGSYAVSGPGNVVTTDLPG------------------------
Rv2519|M.tuberculosis_H37Rv         ILGIGPNVGSYAVSGPGNVVTTDLPG------------------------
MUL_2395|M.ulcerans_Agy99           VLGIGPNIN-VAAGGHGNVVTTALPG------------------------
MMAR_2272|M.marinum_M               YLGIGPNND-FPLP---DQVTAALPG------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       PVGLSGNELLAAQFVQELVSTRRVSDALFEAAEAAFGQTGVVDMVNLAGT
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      WVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVAT
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mb2548|M.bovis_AF2122/97            --------------------------------------------------
Rv2519|M.tuberculosis_H37Rv         --------------------------------------------------
MUL_2395|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2272|M.marinum_M               --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       YLGVSATLNAFKVRGPESFSAPVLPAAPSPVPASDEYGLGGRLPLIDLDT
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          ----RGGAGGLAGRSGADGEAG----------------------DAGTGG
MSMEG_0868|M.smegmatis_MC2_155      GNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGG
MAB_0321c|M.abscessus_ATCC_199      -------TGVFSSSSDCS----------------------------GPGP
TH_4332|M.thermoresistible__bu      -----AVANSLGNAIAGNGG------------------------DAGRFV
Mb2548|M.bovis_AF2122/97            ----QLNEGTLIDIPGGYMQFG---------------------PNTGTPI
Rv2519|M.tuberculosis_H37Rv         ----QLNEGTLIDIPGGYMQFG---------------------PNTGTPI
MUL_2395|M.ulcerans_Agy99           ----QLNEGELINIPQGYMQFG---------------------PNTGTPI
MMAR_2272|M.marinum_M               ----DLNQGVLINTNLGYLQFG---------------------ANPLTPV
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       ATPAQLDLAAKIKALAVPTQQATGIELVSPDGRLIG-------PLNGYLY
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          RGGAG-------------------------GSGGKGGISGTG--------
MSMEG_0868|M.smegmatis_MC2_155      NGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGG
MAB_0321c|M.abscessus_ATCC_199      QPNPG--------------------------SPGDPGTSVAV--------
TH_4332|M.thermoresistible__bu      LIGPG-------------------------GNGGNGGTGLXX--------
Mb2548|M.bovis_AF2122/97            TSVTGAPITVLNVQIGGYDPNGGYWSLPSIFDSGGNHGTLPAVILGTGQT
Rv2519|M.tuberculosis_H37Rv         TSVTGAPITVLNVQIGGYDPNGGYWSLPSIFDSGGNHGTLPAVILGTGQT
MUL_2395|M.ulcerans_Agy99           TSVSGVRVHLEQSER--------------CWDGG---IQLPAAVTG----
MMAR_2272|M.marinum_M               ASVTGSPVTDLQIQINNGPLQPATG---SFIDSGGLYGTIPSSLIPGVPV
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       NPVIGQALFEVGNAFASSSLSSRIKEIVILSVGGQWGSGYEVYAHEKVAR
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          --------TPGGAGQSGQSATGRSGGAGGEG--------GAGGAGGTDD-
MSMEG_0868|M.smegmatis_MC2_155      NGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGT
MAB_0321c|M.abscessus_ATCC_199      ---------SGAQGNPGQAQFLIVP-------------------------
TH_4332|M.thermoresistible__bu      --------XPRPRRRRNHRRTRRRPNGRRPRPPPGR--------------
Mb2548|M.bovis_AF2122/97            TGYAPPGTVISISIHDNQTLLYQYTTTASNSPVVTADPRLN-TGLTPFLL
Rv2519|M.tuberculosis_H37Rv         TGYAPPGTVISISIHDNQTLLYQYTTTASNSPVVTADPRLN-TGLTPFLL
MUL_2395|M.ulcerans_Agy99           -------CLRRFSCHDN-------ARVASTPTTLRVRPQP----------
MMAR_2272|M.marinum_M               GYSVPVGTTITVYTTDGVQLYSQTVTGSTNAPLVVPSNNPFNTGNYPFLL
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       LVGIPEEAIVSLASGHAPVGLSGSELVAARFVQELVSTYEVSSELYHSAE
                                                                                      

Mflv_2178|M.gilvum_PYR-GCK          -----------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      GGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP----
MAB_0321c|M.abscessus_ATCC_199      -----------------------------------------
TH_4332|M.thermoresistible__bu      -----------------------------------------
Mb2548|M.bovis_AF2122/97            GPVYISNNPSGVGTVVFNYPPP-------------------
Rv2519|M.tuberculosis_H37Rv         GPVYISNNPSGVGTVVFNYPPP-------------------
MUL_2395|M.ulcerans_Agy99           -----------------------------------------
MMAR_2272|M.marinum_M               GPIYISNSPTGGGQTIFDF----------------------
MLBr_01183|M.leprae_Br4923          -----------------------------------------
MAV_1346|M.avium_104                -----------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       AAFGQAGLVDLVNLASTYLGASALLNVFEVPVPTAALITTS