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VSGTQSAESDDDADDSEGDASADDAEDAEEFVGDSGNGGSDDDAADDSEKDVDSSTDDGVGDFEGVVLDD AESEADSQLSVPQPASTESTEQSADVANDADGNADPIADAGPEAVTAPVALSGASAPAIPDGPAPVEPMG PLINSLWWAVPKSGGRSTNDASLTLAGTGIYPSVTSLFAFGGRCGLICDGADGTEQNPNGVGGGWLFGDG GDGWSSTLAGIAGGKGGAAGLLWGSGGDGGAGGAGAAGGTGGNAGLLWGNGGHGGAGGAGVNGAVGTSGV NNGRGGDGTAGGSGGAGGNAGLLSGRGGDGGVGGAGGKGGAGAHGSDAVAAEEDGGPGGSGGAGGNAGAG GVGGRGALLFGRGGDGGDGGSAGTGGAGGFGGTGGAIVVTLPGGKLSDSDGAGGAGGVGGAAGLGGDGGG GGLGGLLGQAGVNGDSGATAAAGNAGGVGGAGGLGGRLPIVDLNNASPAQATLAALIKKLGLPIQAATGI QLEDVDGRLVGPLNAYLYNTIIGKAIFDVGNTFSSASLSARVKEIVILSVGGQWGSEYELYAHKLAAQLF GIPADAIAALANGQAPVGLSGNELLAAQFVQELVSTRRVSDALFEAAEAAFGQTGVVDMVNLAGTYLGVS ATLNAFKVRGPESFSAPVLPAAPSPVPASDEYGLGGRLPLIDLDTATPAQLDLAAKIKALAVPTQQATGI ELVSPDGRLIGPLNGYLYNPVIGQALFEVGNAFASSSLSSRIKEIVILSVGGQWGSGYEVYAHEKVARLV GIPEEAIVSLASGHAPVGLSGSELVAARFVQELVSTYEVSSELYHSAEAAFGQAGLVDLVNLASTYLGAS ALLNVFEVPVPTAALITTS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0928 | - | - | 100% (859) | carboxymuconolactone decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 2e-64 | 45.83% (312) | triple helix repeat-containing collagen |
| M. vanbaalenii PYR-1 | Mvan_1569 | - | 7e-55 | 46.65% (328) | hypothetical protein Mvan_1569 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1002 | PE_PGRS16 | 3e-73 | 43.23% (384) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-64 | 44.17% (369) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv1068c | PE_PGRS20 | 7e-75 | 53.15% (286) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01556 | infB | 3e-06 | 35.14% (111) | translation initiation factor IF-2 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 6e-32 | 38.10% (315) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_3105 | - | 4e-69 | 52.70% (296) | PE-PGRS family protein |
| M. avium 104 | MAV_4827 | - | 3e-18 | 40.48% (168) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 8e-60 | 44.26% (305) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 5e-34 | 40.00% (270) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4399 | - | 6e-69 | 48.05% (333) | PE-PGRS family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1002|M.bovis_AF2122/97 --------------------------------------------------
Rv1068c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4399|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3105|M.marinum_M --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 --------------------------------------------------
Mb1002|M.bovis_AF2122/97 --------------------------------------------------
Rv1068c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4399|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3105|M.marinum_M --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1 -----MSGTQSAESDDDADDSEGDASADDAEDAEEFVGDSGNGGSDDDAA
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 -------------------------------MAGKARVHELAKELGVTSK
Mb1002|M.bovis_AF2122/97 ------------MSFVVTAPPVLASAASDLGGIASMISEANAMAAVRTTA
Rv1068c|M.tuberculosis_H37Rv ------------MSYMIAVPDMLSSAAGDLASIGSSINASTRAAAAATTR
MUL_4399|M.ulcerans_Agy99 ------------MSYLLVAPELLTSAATDLEGIASALSTANLAAAVPTTG
MMAR_3105|M.marinum_M ------------MWYLSVAPDELAAAATELRDVGSIVSTVNAAAAVPTTA
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1 DDSEKDVDSSTDDGVGDFEGVVLDDAESEADSQLSVPQPASTESTEQSAD
MAB_4284c|M.abscessus_ATCC_199 ---------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQV
MAV_4827|M.avium_104 ------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTG
MLBr_01556|M.leprae_Br4923 EVLARLNEQGEFVKSASSTVEAPVARRLRESFGGIKPAADKGAEQVATKA
Mb1002|M.bovis_AF2122/97 LAPAAADEVSAAIAALFSSYARDYQTLSVQVTAFHVQFAQTLTNAGQLYA
Rv1068c|M.tuberculosis_H37Rv LLPAAADEVSAHIAALFSGHGEGYQAIARQMAAFHDQFTLALTSSAGAYA
MUL_4399|M.ulcerans_Agy99 MLAAGADEVSAAVASLFAGYGQAYQSISLQANAFQAQFIQAINGAGGAYV
MMAR_3105|M.marinum_M LWPAAADEVSAAIAALFSSHAQQYQSLSVQVAAYHDQFVRALAAGGASYS
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1 VANDADGNADPIADAGPEAVTAPVALSGASAPAIPDGPAPVEPMGPLINS
MAB_4284c|M.abscessus_ATCC_199 GAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILS
MAV_4827|M.avium_104 ADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDA
MLBr_01556|M.leprae_Br4923 QAKRLGESLDQTLDRALDKAVAGNGATTAAPVQVDHSAAVVPIVAGEGPS
Mb1002|M.bovis_AF2122/97 VVDVGNGV-LLKTEQQVLGVINAPTQTLVG--------RPLIGDGTHGAP
Rv1068c|M.tuberculosis_H37Rv SAEATN------VEQQVLGLINAPTQALLG--------RPLIGNGADGTA
MUL_4399|M.ulcerans_Agy99 AAEAASTSPLQAFEDTVLGVINAPTQTLLG--------RPLIGDGAAGTV
MMAR_3105|M.marinum_M LAEAASAS----PLEQLLDLINLPSQTLLG--------RPLIGDGADGTA
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_3810|M.thermoresistible__bu ----------------------------------------VDGDGGSGGR
Mvan_0928|M.vanbaalenii_PYR-1 LWWAVPKSGGRSTNDASLTLAGTGIYPSVTSLFAFGGRCGLICDGADGTE
MAB_4284c|M.abscessus_ATCC_199 PSLLSPRDNDFLSHNDTDFASHNPIASGNQ-------VMSPSGNVDSFNR
MAV_4827|M.avium_104 LAARRIDNVMLVSAFLAAAALAQNVGGAMG--YERTAVLLVEPDTATLAV
MLBr_01556|M.leprae_Br4923 TAHREELAPPAGQPSEQPGVPLPGQQGTPAAPHPGHPGMPTGPHPGPAPK
.
Mb1002|M.bovis_AF2122/97 GTGQNGGAGGILWGNGGNGGSG--APGQPGGRGGDAGLFG-HGGHGGVGG
Rv1068c|M.tuberculosis_H37Rv AN-PNGGAGGLLYGNGGNGFSQT-TAGLTGGTGGSAGLIG-NGGNGGAGG
MUL_4399|M.ulcerans_Agy99 AN-PNGGAGGFLYGNGGNGFSQT-TAGVAGGAGGAAGLIG-NGGMGGAGG
MMAR_3105|M.marinum_M SA-PNGGAGGLLYGNGGNGYDNSASAGVAGGAGGSAGLIG-NGGIGGAGG
Mflv_5091|M.gilvum_PYR-GCK QN------GGILFGNGGSGWNSD-VVGMDGGNGGNGGLFGGNGGNGGNGL
MSMEG_0868|M.smegmatis_MC2_155 DN-PNGGTGGLLFGDGGHGYDGS-AAGLAGGNGGNAGLFG-NGGNGGVGW
TH_3810|M.thermoresistible__bu TG---------LFSKLSR-----------GGDGGDGGLGG-NGGHG----
Mvan_0928|M.vanbaalenii_PYR-1 QN-PNGVGGGWLFGDGGDGWSST-LAGIAGGKGGAAGLLWGSGGDGGAGG
MAB_4284c|M.abscessus_ATCC_199 GPLLDLSFGDLQFGNRDTTAIGD---GAVAVGGSNSGPIASGQGSTAVNG
MAV_4827|M.avium_104 VETSDGSIPDVYKQQIRAESYGDAAGQLSAMVAGLEKLESLPGGLLLVGS
MLBr_01556|M.leprae_Br4923 PGGRPPRVGNNPFSSAQSVARPIPRPPAPRPSASPSSMSPRPGGAVGGGG
. .. *
Mb1002|M.bovis_AF2122/97 PGIAGAAGTAGLPGGNGANGGSGGIGGAGGAGGNGG--LLFGNGGAGGQG
Rv1068c|M.tuberculosis_H37Rv ---------------AGANGG---------AGGNGG--WLYGSGGNGGAG
MUL_4399|M.ulcerans_Agy99 ---------------AGAAGG---------AGGTGG--WWFGNGGVGGAG
MMAR_3105|M.marinum_M ---------------ALAAGG---------AGGTGG--LLFGNGGSGGAG
Mflv_5091|M.gilvum_PYR-GCK ---------------GGGNGG---------NGGNAGAFALFGNGGNGGNG
MSMEG_0868|M.smegmatis_MC2_155 ---------------AGLDGG---------NGGSGG--LLMGIGGAGGAG
TH_3810|M.thermoresistible__bu -------------------GG----------TGIISLLSLAGNGGNGGNG
Mvan_0928|M.vanbaalenii_PYR-1 ---------------AGAAGG---------TGGNAG--LLWGNGGHGGAG
MAB_4284c|M.abscessus_ATCC_199 ---------------DVRDSN--------IINADHGSNVGVDQSQTRVGG
MAV_4827|M.avium_104 ----------------GVDVAP--------LKQVLQTTTFLDVSVAEEPE
MLBr_01556|M.leprae_Br4923 P--------------RPPRTGVP------RPGGGRPGAPVGGRSDAGGGN
. .
Mb1002|M.bovis_AF2122/97 GSGGLGGSGGTGGAGMAAGPAG-----GTGGIGGIG---------GIGGA
Rv1068c|M.tuberculosis_H37Rv G----------------AGPAG-----AIGAPGVAG---------GAGGA
MUL_4399|M.ulcerans_Agy99 G----------------AGTAG-----AVGFNGVSG---------GAGGA
MMAR_3105|M.marinum_M GLGAVGGQGGGAGTLSLVGSGGDGGHGGEGTPGGSG---------GTGGG
Mflv_5091|M.gilvum_PYR-GCK GVGVVGATGAVG--APGVAGATGATGVTSGVVGGNGEDAVGYGATGAAGA
MSMEG_0868|M.smegmatis_MC2_155 GVGADGTSAHVDGGTGGTGGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGA
TH_3810|M.thermoresistible__bu YR-------------------------TTDNNALDG---------GHGGN
Mvan_0928|M.vanbaalenii_PYR-1 GAGVNG------------AVGTSGVNNGRGGDGTAG---------GSGGA
MAB_4284c|M.abscessus_ATCC_199 DYTNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFN-----TDRSTNIGS
MAV_4827|M.avium_104 TALARG--------AALAAANAPLFASSTAALAYAQ----------DPGT
MLBr_01556|M.leprae_Br4923 YRGGGVGALPGGGSGGFRGRPGGGGHGGGGRPGQRG---------GAAGA
*
Mb1002|M.bovis_AF2122/97 GGVGGHG-------------------------SALFGHGGINGDGGTGGM
Rv1068c|M.tuberculosis_H37Rv GGTAG-----------------------------LFGNG---------GA
MUL_4399|M.ulcerans_Agy99 GGAAG-----------------------------WWGAG---------GA
MMAR_3105|M.marinum_M GGSAG-----------------------------LFGRG---------GF
Mflv_5091|M.gilvum_PYR-GCK AGAAGAAGAAG--------------AVG--SAGAAGEAGETGTWGNAGLP
MSMEG_0868|M.smegmatis_MC2_155 AGAAGNGGDGGNGGFGYVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGP
TH_3810|M.thermoresistible__bu GGNVG--------------------------FFSLFNLG---------GA
Mvan_0928|M.vanbaalenii_PYR-1 GGNAG----------------------------LLSGRGG------DGGV
MAB_4284c|M.abscessus_ATCC_199 GNTTN----------------------------TEIGSHNQANIGTSTSA
MAV_4827|M.avium_104 GAVDQYS-----------------------LPDYLYVPVDPEPGDDELAY
MLBr_01556|M.leprae_Br4923 FGRPGGAPRRG--------------------RKSKRQKRQEYDSMQAPVV
Mb1002|M.bovis_AF2122/97 GGQGGAGGNGWA-----------AEGITVGIGEQGGQG------GDGGAG
Rv1068c|M.tuberculosis_H37Rv GGAGGAGG-------------------------AGGRG------GDGGS-
MUL_4399|M.ulcerans_Agy99 GGQGGTGGMAGG-----------YDNVNGVFGITAGNG------GDGGAG
MMAR_3105|M.marinum_M GGSGGTGGDGVVG------SPAALDGGAGGTGGSGGRGGLFAVGGDGGHG
Mflv_5091|M.gilvum_PYR-GCK GKAGDAGGAG----AVGAAG---AAGTVGTAGATGGTG----TGANGGAG
MSMEG_0868|M.smegmatis_MC2_155 GKGGGGGGGGGGAILIGANGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTG
TH_3810|M.thermoresistible__bu GGWGGSGVDG--------------------VDVVGGNP-------DGGTP
Mvan_0928|M.vanbaalenii_PYR-1 GGAGGKGGAG------------AHGSDAVAAEEDGGPG------GSGGAG
MAB_4284c|M.abscessus_ATCC_199 GGSAAVGGNAG---------------LAGNAGLAGNAG----LAGNAGLA
MAV_4827|M.avium_104 SAVGEEDAESPT-----------VVIEKLFLPEDSEPRRRPVLLVGSGLA
MLBr_01556|M.leprae_Br4923 GGVRLPHGNGETIRLARG-----ASLSDFAEKIDANPAALVQALFNLGEM
. . . *
Mb1002|M.bovis_AF2122/97 GAG----------GIGGSAGGIG---------------------------
Rv1068c|M.tuberculosis_H37Rv ---------------AGWLSGNG---------------------------
MUL_4399|M.ulcerans_Agy99 GR-------------GGWLFGDA---------------------------
MMAR_3105|M.marinum_M GIG----------GNGARGADGV---------------------------
Mflv_5091|M.gilvum_PYR-GCK GVG-----GVGGTGAAGAAGGAG------GLGETGTTG------------
MSMEG_0868|M.smegmatis_MC2_155 GTGRVIAEGTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVS
TH_3810|M.thermoresistible__bu GAH-------------GESHTPG---------------------------
Mvan_0928|M.vanbaalenii_PYR-1 GNAG-----------AGGVGGRG---------------------------
MAB_4284c|M.abscessus_ATCC_199 GNAG----------LAGNAGLAG---------------------------
MAV_4827|M.avium_104 VVG-----------ISAVLALE----------------------------
MLBr_01556|M.leprae_Br4923 VTATQSVGDETLELLGSEMNYNVQVVSP----------------------
Mb1002|M.bovis_AF2122/97 --GSQGAGGHGGDGGQGGAGGSG---------------------------
Rv1068c|M.tuberculosis_H37Rv --GDAGTGGGGGNAGNGGNGGSA---------------------------
MUL_4399|M.ulcerans_Agy99 --GAGGQGGLGGDGNYAGQGSYG---------------------------
MMAR_3105|M.marinum_M --GDGESGTAGGNGGAGGAGGVGG--------------------------
Mflv_5091|M.gilvum_PYR-GCK --GAGGVGGQGTAGGTGGVGGIG-----------------------GAGS
MSMEG_0868|M.smegmatis_MC2_155 GTATGGRGGDGIDGGTGGAGGMGEIYSGADGEATGISAGGDGGSATGADS
TH_3810|M.thermoresistible__bu -VYTDRQGEDGEDGTGTGIGGRG---------------------------
Mvan_0928|M.vanbaalenii_PYR-1 -ALLFGRGGDGGDGGSAGTGGAG---------------------------
MAB_4284c|M.abscessus_ATCC_199 --NAGLAGNAGLAGNAGLAGNAG---------------------------
MAV_4827|M.avium_104 ---IALAIGIRTTGTVALQPTPN---------------------------
MLBr_01556|M.leprae_Br4923 -EDEDRELLEPFDLTYGEDQGDE---------------------------
Mb1002|M.bovis_AF2122/97 ------------------------GVGGGGAGAGGDGGAGGIGGT-----
Rv1068c|M.tuberculosis_H37Rv ------------------------GWLSGNGGTGGGGGTAGAGGQ-----
MUL_4399|M.ulcerans_Agy99 ------------------------GVG-GAGGAGGAAGMFGSGGS-----
MMAR_3105|M.marinum_M -----------------------TGILSGSDGVGGGGGNGGRGGDGIRGA
Mflv_5091|M.gilvum_PYR-GCK TGAVGG-----------VGGKGIQGGQGLQGGKGGDGGAGGKGGDADSMG
MSMEG_0868|M.smegmatis_MC2_155 LGGRGGTSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMA
TH_3810|M.thermoresistible__bu ----------------------------GNGGSSSGTHPMAEDGE-----
Mvan_0928|M.vanbaalenii_PYR-1 ----------------------------GFGGTGGAIVVTLPGGKLSDSD
MAB_4284c|M.abscessus_ATCC_199 --------------------------LAGNAGLAGNAGLAGNAGLA----
MAV_4827|M.avium_104 -----------------------QHLIVPTEQAPAPPPVQASAPQ-----
MLBr_01556|M.leprae_Br4923 ------------------------DELQVRPPVVTVMGHVDHGKTRLLDT
Mb1002|M.bovis_AF2122/97 -----------------------GGNGSIGG-------------------
Rv1068c|M.tuberculosis_H37Rv -----------------------GGNGNSGI-------------------
MUL_4399|M.ulcerans_Agy99 -----------------------GGAGGEGG-------------------
MMAR_3105|M.marinum_M DGVLD------------GESGYLGGSGGAGG-------------------
Mflv_5091|M.gilvum_PYR-GCK S------------------AGATGGKGGNGGNGGRGGLFG----------
MSMEG_0868|M.smegmatis_MC2_155 AGATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATSG
TH_3810|M.thermoresistible__bu -----------------------HVKALDGR-------------------
Mvan_0928|M.vanbaalenii_PYR-1 G---------------------AGGAGGVGG-------------------
MAB_4284c|M.abscessus_ATCC_199 -----------------------GNAGLAGN-------------------
MAV_4827|M.avium_104 -----------------------PKISVPEP-------------------
MLBr_01556|M.leprae_Br4923 IRKAN------------------VREAEAGGITQHIG-------------
.
Mb1002|M.bovis_AF2122/97 -----AAGNGGNGGRGGAGGMATAG----------SDGGNGGGGGNGGVG
Rv1068c|M.tuberculosis_H37Rv -----DPGNGGQG----------------------ADTGNAGNGGHG---
MUL_4399|M.ulcerans_Agy99 -----AFGDGNAG-----------------------GSGSGGHGGNG---
MMAR_3105|M.marinum_M -----AGGAGGGGSQVGSDGVGGAG----------GTGGAGGHGARGADG
Mflv_5091|M.gilvum_PYR-GCK -----KGGNAGNG----------------------ADGGTGGAGGAGGTG
MSMEG_0868|M.smegmatis_MC2_155 HGGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTG
TH_3810|M.thermoresistible__bu -----PGLDGGNG----------------------SHGGNGGHGGRGG--
Mvan_0928|M.vanbaalenii_PYR-1 -----AAGLGGDG----------------------GGGGLGGLLGQAGVN
MAB_4284c|M.abscessus_ATCC_199 -----AGLAGNAG-----------------------LAGNAGLAGNAG--
MAV_4827|M.avium_104 ----VAAPKPLSPP---------------------VAAPLPAAPPPAAPP
MLBr_01556|M.leprae_Br4923 ---AYQVGVDLDGSERLITFIDTPG--------HEAFTAMRARGAKATDI
.
Mb1002|M.bovis_AF2122/97 VGS--AGGAGG-----------------TGGDGGAAGAGGAPGHGYFQQP
Rv1068c|M.tuberculosis_H37Rv ------GSAAK-----------------LFGDGGAGGAG-----------
MUL_4399|M.ulcerans_Agy99 ------GNGGW-----------------LYGDAGAGGQG-----------
MMAR_3105|M.marinum_M LLDGEAGSKGG-----------------AGGGGGAGGAGGAG--------
Mflv_5091|M.gilvum_PYR-GCK G-TGGAGGTGG-----------------TGGTGGIGGAGSTG--------
MSMEG_0868|M.smegmatis_MC2_155 GATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTF--------
TH_3810|M.thermoresistible__bu ----------------------------FLGIGGSGGWG-----------
Mvan_0928|M.vanbaalenii_PYR-1 GDSGATAAAGN-----------------AGGVGGAGGLGGRLP-------
MAB_4284c|M.abscessus_ATCC_199 ----LAGNAG------------------LAGNAGLAGNAG----------
MAV_4827|M.avium_104 LPEAPPIPAAP----------------PVVPVPVVVPPVPVP--------
MLBr_01556|M.leprae_Br4923 AILVVAADDGVMP--------------QTVEAINHAQAADVP--------
Mb1002|M.bovis_AF2122/97 APQGLPIGTGGTGGEGGAGGA--GGDGGQGDIGFDGGRGGDGGPGGGGGA
Rv1068c|M.tuberculosis_H37Rv -------GMGSTGGTGGGG-------------GFGGGTGGNGGNGHAGGA
MUL_4399|M.ulcerans_Agy99 -------GNAAPGAYSDNL-----------------GTFQSSYTSGNGGA
MMAR_3105|M.marinum_M -SQAGSDGVGGAGGDGGDGGHGAYGDGKAGGGGGAGGRGGDGGDGDTGGA
Mflv_5091|M.gilvum_PYR-GCK -GTGGTGGTGGTGGTGGTG-----GTGGTGGTGGTGGKGGTGGTGGAGGT
MSMEG_0868|M.smegmatis_MC2_155 -VNAGANGNGGAGGAGGVSE----GEGGTGGHGGDGGRGGDGALGGNGGT
TH_3810|M.thermoresistible__bu -------GHGGNGGDTDAD----------------GGNGGDGGNGGSAGR
Mvan_0928|M.vanbaalenii_PYR-1 -------IVDLNNASPAQATLAALIKKLGLPIQAATGIQLEDVDGRLVGP
MAB_4284c|M.abscessus_ATCC_199 -----LAGNAAVAGNAAVAGN-----------AAVAGNAAVGGVLNTGVS
MAV_4827|M.avium_104 ----VPVRIPVPDPVSPPQLLAPPRLSVPQPVQPPVRVPQPPSPPQVGGT
MLBr_01556|M.leprae_Br4923 --IVVAVNKIDKEGADPAKIRGQLTEYGLVAEDFGGDTMFIDISAKVGTN
Mb1002|M.bovis_AF2122/97 G----GDGSGTFNAQANNGG-------DGGAGGVGGAGGTG---------
Rv1068c|M.tuberculosis_H37Rv G----GSG---------------------GTAGLLGSGGSG---------
MUL_4399|M.ulcerans_Agy99 G----GNG---------------------GVAGMIGTGGAG---------
MMAR_3105|M.marinum_M A----GNGG---DGGEGGNA-------VANSGRGGGTGGAG---------
Mflv_5091|M.gilvum_PYR-GCK G----GDGGTGGTGGTGGTG---------GTGGTGGTGGAG---------
MSMEG_0868|M.smegmatis_MC2_155 GGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTA
TH_3810|M.thermoresistible__bu G----------------------------GTGGLRGVFGIN---------
Mvan_0928|M.vanbaalenii_PYR-1 LNAYLYNTIIG-----------------KAIFDVGNTFSSASLSARVKEI
MAB_4284c|M.abscessus_ATCC_199 G----------------------------AIGGSSHVGGAIN--------
MAV_4827|M.avium_104 VP--------------------------QSPPQHQTPPGEG---------
MLBr_01556|M.leprae_Br4923 IEALLEAVLLT------------------ADAALDLRANSG---------
.
Mb1002|M.bovis_AF2122/97 ---GTGGVGADGGR-------GGDSGRGG-----------------DGGN
Rv1068c|M.tuberculosis_H37Rv ---GTGGDGGNGGL-------GAGSGAKG-----------------NGGN
MUL_4399|M.ulcerans_Agy99 ---GAGGAGGVNAFD-----SGGGGGGGG-----------------NGGN
MMAR_3105|M.marinum_M ---GVGGDGGNGTNG-----VGGAGGHGG-----------------MGGN
Mflv_5091|M.gilvum_PYR-GCK --DGTGGTGGTGG----TGGQGGQGGQGG-----------------TGGT
MSMEG_0868|M.smegmatis_MC2_155 TGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGD
TH_3810|M.thermoresistible__bu -----GGNG-----------RAGLGGRGX-----------------XXXG
Mvan_0928|M.vanbaalenii_PYR-1 VILSVGGQWGSEYELYAHKLAAQLFGIPAD-----------AIAALANGQ
MAB_4284c|M.abscessus_ATCC_199 --ESLGGSGSVGGST-----AVGGGAHTG-----------------VGGG
MAV_4827|M.avium_104 ---TPPKPDGPGNYG------GGHVPTPG-----------------AGGS
MLBr_01556|M.leprae_Br4923 --MEAQGVAIEAHLDRGRGPVATVLVQRG--------------TLRIGDS
Mb1002|M.bovis_AF2122/97 AGHGGAAQFSGRGAYGGEGGSGGAGGNAGGAGTGGTAGSGGAGGFGGNGA
Rv1068c|M.tuberculosis_H37Rv GGDG---------------------------------GKGGDAQLIGNGG
MUL_4399|M.ulcerans_Agy99 GGAG-----------------------------------GASGALIEAGG
MMAR_3105|M.marinum_M AGSSDAAN----------------GAVGSRGGDGGAGGKGGQGTTGGDGG
Mflv_5091|M.gilvum_PYR-GCK GGQGG-LGGGGGTG-----------------------GQGGTGGTGGQGG
MSMEG_0868|M.smegmatis_MC2_155 GGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGG
TH_3810|M.thermoresistible__bu GGVGAAVR-------------------------------SGNGVFSGGGG
Mvan_0928|M.vanbaalenii_PYR-1 APVGLSGNE--------------LLAAQFVQELVSTRRVSDALFEAAEAA
MAB_4284c|M.abscessus_ATCC_199 VSTGVGVG-----------------------------SHVGGGISESLGG
MAV_4827|M.avium_104 GGSG-----------------------------------GGHVPTPGAGG
MLBr_01556|M.leprae_Br4923 VVAGDAYGRVR-------------RMVDEHGVDIEAALPSSPVQVIGFTS
. .
Mb1002|M.bovis_AF2122/97 DGGNG--------------GNGGNGGFGGINGTFGTNGAGGTGGLGTLLG
Rv1068c|M.tuberculosis_H37Rv NGGNG--------------GKGGTGLMPGIN---GTGGAGGSRGQ-----
MUL_4399|M.ulcerans_Agy99 VGGSG--------------GGGGAGVVGPPAGNPGNDGLDG---------
MMAR_3105|M.marinum_M NGGSA--------------GKGGTGGSAVQTNDAGNGGDGGAGGDG----
Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGG
MSMEG_0868|M.smegmatis_MC2_155 NGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAAN
TH_3810|M.thermoresistible__bu TPSAG------------------FGVPTTIQFPAGSCTSRAVSREG----
Mvan_0928|M.vanbaalenii_PYR-1 FGQTGVVDMVN-------LAGTYLGVSATLNAFKVRGPESFSAPVLPAAP
MAB_4284c|M.abscessus_ATCC_199 SGSVG--------------GSTAVGGGAHTGVGGGVSTGVGVGSHVG---
MAV_4827|M.avium_104 SGGSGG-------------GHVPTPGTGGPGGTGGSGGGHVPTPGAG---
MLBr_01556|M.leprae_Br4923 VPGAGDNFLVVD-------EDRIARQIADRRSARKRNALAARSRKRISLE
.
Mb1002|M.bovis_AF2122/97 GHNGNIGLNGATGGIGSTTLTNATVPLQLVNTTEPVVFISLNGGQMVPVL
Rv1068c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4399|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3105|M.marinum_M --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK PGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKAG----------
MSMEG_0868|M.smegmatis_MC2_155 PGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLG----------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1 SPVPASDEYGLGG-------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 DLDSALKETSQLN-------------------------------------
Mb1002|M.bovis_AF2122/97 LDTGSTGLVMDSQFLTQNFGPVIGTGTAGYAGGLTYNYNTYSTTVDFGNG
Rv1068c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4399|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3105|M.marinum_M --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -------------------------------ATGAAGASGGKGAQGATGA
MSMEG_0868|M.smegmatis_MC2_155 -------------------------------GNATGTATAGKGGEASNGG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 --------------------------------------------------
Mb1002|M.bovis_AF2122/97 LLTLPTSVNVVTSSSPGTLGNFLSRSGAVGVLGIGPNNGFPGTSSIVTAM
Rv1068c|M.tuberculosis_H37Rv -----------ISGNPGTPGQ-----------------------------
MUL_4399|M.ulcerans_Agy99 -----------VTGASGLLFGG----------------------------
MMAR_3105|M.marinum_M ------GIGTLGPGGDGGAGGNGGSGGDGNTQPVGHSLGGGGGVGGNGGQ
Mflv_5091|M.gilvum_PYR-GCK QGATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG--------
MSMEG_0868|M.smegmatis_MC2_155 VAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAI
TH_3810|M.thermoresistible__bu -----------IMPSSRAASARAGAACASSTSRSRRSFCCSRA-------
Mvan_0928|M.vanbaalenii_PYR-1 --RLPLIDLDTATPAQLDLAAKIKALAVPTQQATGIELVSPDGRLIGPLN
MAB_4284c|M.abscessus_ATCC_199 -------------GGISESLGGSGSVGGSTAVGGGAHTGVGGGVNTGVGV
MAV_4827|M.avium_104 -----------TPGGSGGGHLPFPGAGSTPGGSGGGHLPTPGAGTPGGGL
MLBr_01556|M.leprae_Br4923 ---------LILKGDNAGTVEALEEALMGIQVDDEVALRVIDRGVGGITE
Mb1002|M.bovis_AF2122/97 PGLLNNGVLIDESAGILQFGPNTLTGGITISGAPISTVAVQI-----DNG
Rv1068c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4399|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3105|M.marinum_M GGAGGQGITGGSGGAGGSGGNGGTGGDDTENAEPSAGGAGGE-----GGM
Mflv_5091|M.gilvum_PYR-GCK ---TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------AA
MSMEG_0868|M.smegmatis_MC2_155 HGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1 GYLYNPVIGQALFEVGNAFASSSLSSRIKEIVILSVGGQWGSGYEVYAHE
MAB_4284c|M.abscessus_ATCC_199 GSHVGGGISESLGGSGSVGGSTAVGGGAHTSAIN---------------D
MAV_4827|M.avium_104 GGFGGGHAPAPGGGLGGGGGHAPAPGGGLG--------------------
MLBr_01556|M.leprae_Br4923 TNVNLASASDAIIIGFNVRAEGKATELASREGVEIRYYLVIYQAIDDIEK
Mb1002|M.bovis_AF2122/97 PLQQAPVMFDSGGINGTIPSALAS--------------LPSGGFVPAGTT
Rv1068c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4399|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3105|M.marinum_M GGGGGDGVVGTGGMGGGGGQGGAG--------------GDAIDSVGGIGG
Mflv_5091|M.gilvum_PYR-GCK GEDGDAGSGGSG-INGGAGGAGG-----------------AGGEGGEGGD
MSMEG_0868|M.smegmatis_MC2_155 GNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGD
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1 KVARLVGIPEEAIVSLASGHAPVG-------------LSGSELVAARFVQ
MAB_4284c|M.abscessus_ATCC_199 ALGGSGSVGGSTAVGGG-----------------------AHTSAINESM
MAV_4827|M.avium_104 GFGGGHSGGGLGGLGGGHK-------------------------------
MLBr_01556|M.leprae_Br4923 ALRGMLKPIYEENQLGRAEIRALFRSSKVGIIAGCIISSGVVRRNAKVRL
Mb1002|M.bovis_AF2122/97 ISVYTSDGQTLLYSYTTTATNTPFVTSGGVMNTGHVPFAQQPIYVSYSPT
Rv1068c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4399|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3105|M.marinum_M KGGGGADGGGGGASSTSTGGAPGGVGGDGDDGDPPTGQTGGGGGTGGGGG
Mflv_5091|M.gilvum_PYR-GCK GGKGGAG--AEGGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGG
MSMEG_0868|M.smegmatis_MC2_155 GSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1 ELVSTYEVSSELYHSAEAAFGQAGLVDLVNLASTYLGASALLNVFEVPVP
MAB_4284c|M.abscessus_ATCC_199 NSSINASHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPG
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 LRDNIVVTDNLTVTSLRREKDDVTEVREGFECGMTLGYSDIKEGDVIESY
Mb1002|M.bovis_AF2122/97 AIGTTTFN
Rv1068c|M.tuberculosis_H37Rv --------
MUL_4399|M.ulcerans_Agy99 --------
MMAR_3105|M.marinum_M APGVV---
Mflv_5091|M.gilvum_PYR-GCK AAGDSDD-
MSMEG_0868|M.smegmatis_MC2_155 TTGANNP-
TH_3810|M.thermoresistible__bu --------
Mvan_0928|M.vanbaalenii_PYR-1 TAALITTS
MAB_4284c|M.abscessus_ATCC_199 AEHH----
MAV_4827|M.avium_104 --------
MLBr_01556|M.leprae_Br4923 ELVEKQRA