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SGTAHAPGKTRLFANVTVAVGLGGAALGAAALLAPQASAAPEEWLPAGPSSECPPPTDGCANVAAVGGVH GAQGPANLATPQTSGSPLFRPLFGNGADAPADCVGNACNGRDGGLIWGNGGAGANGGHGGNAGLVGNGGR GGDATTPGRSGGHGGNGGRLWGNGGDGGNGAPGVLGPAGTAPIPPSSLPAATGTRGDSPPYGYGNLVGGD GGTGADGGRYAFGANWSLDLPVGGAGGAGGWANSIDGSATGGNGGDGGNGAFGGRGGNGGAGGSAYGRGG ITTGGNGGAGGHGSTGAAGGRGGDGASASGGYAVGGNGGDGGRGGAGATGGTGGTGGAGGDGGRGGLLGG HGGKGGNAGLGGNGGTGGTGGVGGDGGVGGGILTATGVVGAGGSGGAGGTGGRGGDGGDGGQAGRGGAGG LAGRSGADGEAGDAGTGGRGGAGGSGGKGGISGTGTPGGAGQSGQSATGRSGGAGGEGGAGGAGGTDD*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_2178 | - | - | 100% (489) | hypothetical protein Mflv_2178 |
M. gilvum PYR-GCK | Mflv_5091 | - | 5e-96 | 44.98% (498) | triple helix repeat-containing collagen |
M. gilvum PYR-GCK | Mflv_1516 | - | 3e-67 | 39.76% (493) | hypothetical protein Mflv_1516 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1096c | PE_PGRS19 | 4e-97 | 47.54% (448) | PE-PGRS family protein |
M. tuberculosis H37Rv | Rv3367 | PE_PGRS51 | 1e-95 | 44.51% (492) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01556 | infB | 2e-11 | 34.88% (129) | translation initiation factor IF-2 |
M. abscessus ATCC 19977 | MAB_4284c | - | 6e-45 | 35.38% (390) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_4149 | - | 1e-102 | 50.23% (434) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 1e-21 | 38.83% (188) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 7e-67 | 40.74% (432) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 1e-41 | 40.57% (281) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4381 | - | 4e-87 | 45.88% (497) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_2459 | - | 1e-106 | 45.39% (542) | PE_PGRS family protein |
CLUSTAL 2.0.9 multiple sequence alignment Rv3367|M.tuberculosis_H37Rv ----MSFVVAVPEALAAAASDVANIGSALSAANAAAAAGTTGLLAAGADE MMAR_4149|M.marinum_M ----MSFVVVSPEVLAVAGRDLASIGSAISQANVAAAAPTMGALAAGADE Mb1096c|M.bovis_AF2122/97 ----MSFVLVSPSQLMAAAADVAGIGSAISAANAAALAPTSVLAAAGADE MUL_4381|M.ulcerans_Agy99 ----MSFVNVAPQQLSAAAAEVAGIGSAVSTASRAAAAPTMGLLAAGADE Mflv_2178|M.gilvum_PYR-GCK ----MSGTAHAP-GKTRLFANVT----VAVGLGGAALGAAALLAPQASAA Mvan_2459|M.vanbaalenii_PYR-1 MARRLSKTVDASDGNILRCAGAGPRYWIAAGTGGAAVMGVGLLAGLCSET MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMPVVA MAV_4827|M.avium_104 MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPDR MLBr_01556|M.leprae_Br4923 -MAGKARVHELAKELGVTSKEVLARLNEQGEFVKSASSTVEAPVARRLRE Rv3367|M.tuberculosis_H37Rv VSAALASLFSGHAVSYQQVA-----------------------AQATA-L MMAR_4149|M.marinum_M VSAAVAAVFSGHAQAYQALG-----------------------AQVAA-F Mb1096c|M.bovis_AF2122/97 VSAAVAALFSAHAGQYQQLG-----------------------ARAAL-F MUL_4381|M.ulcerans_Agy99 VSVGIAALFADHAQEYEVVL-----------------------EEFLDGL Mflv_2178|M.gilvum_PYR-GCK P-----EEWL-PAGPS----------------------------SECPPP Mvan_2459|M.vanbaalenii_PYR-1 P-----ATVERPVRLASFDS---------------------LIVANSPVP MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRD MAV_4827|M.avium_104 VISAILGTREGAADAG----------------------------LQLSSI MLBr_01556|M.leprae_Br4923 SFGGIKPAADKGAEQVAT-------------------------KAQAKRL Rv3367|M.tuberculosis_H37Rv HDQFVQALTGAGGSYALTEAANVQ-------------------------- MMAR_4149|M.marinum_M HDQLVTALDAAAGKYASAEVANASPL------------------------ Mb1096c|M.bovis_AF2122/97 HEQFVQALTGAASAYASAEATNVE-------------------------- MUL_4381|M.ulcerans_Agy99 QGGSGRTLDAAAKAYASAEAASAAALGQVWDATAGPTAVLSDAYEAAAAA Mflv_2178|M.gilvum_PYR-GCK TDGCANVAAVGGVHGAQGPANLATPQ------------------------ Mvan_2459|M.vanbaalenii_PYR-1 EDIWLFGAAGSPKRDRSGPATAAAPG------------------------ MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPA------------------------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 NDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNR--------------- MAV_4827|M.avium_104 GVTWTDQLEAAALRDALAARRIDN-------------------------- MLBr_01556|M.leprae_Br4923 GESLDQTLDRALDKAVAGNGATTAAP------------------------ Rv3367|M.tuberculosis_H37Rv ----------------------------------------QNLLNAINAP MMAR_4149|M.marinum_M ----------------------------------------QAVLDVVNAP Mb1096c|M.bovis_AF2122/97 ----------------------------------------QQVLGLINAP MUL_4381|M.ulcerans_Agy99 AKAGEGPVGVVQAVIGAESDALLVQPAHTLSQAWITSPLGQVVDPVINAP Mflv_2178|M.gilvum_PYR-GCK ---------------------------------------TSGS-PLFRP- Mvan_2459|M.vanbaalenii_PYR-1 ---------------------------------------VAAVRPMIGPG MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------------APSLRPISGLL TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------GPLLDLSFGDL MAV_4827|M.avium_104 ---------------------------------------VMLVSAFLAAA MLBr_01556|M.leprae_Br4923 ----------------------------------VQVDHSAAVVPIVAGE Rv3367|M.tuberculosis_H37Rv TQALLGRPLIGDGAVGTASS------------------------------ MMAR_4149|M.marinum_M AQALLGRPLIGNGDDGVAGTG----------------------------- Mb1096c|M.bovis_AF2122/97 TQALWGRPLIGNGADGTAAN------------------------------ MUL_4381|M.ulcerans_Agy99 FEAAIGRDLIGNGAPGVAGVNG---------------------------- Mflv_2178|M.gilvum_PYR-GCK --------LFGNGADAPADCVG---------------------------- Mvan_2459|M.vanbaalenii_PYR-1 ------GWLIGDGADAVEDCEG---------------------------- MSMEG_0868|M.smegmatis_MC2_155 SVVTLGTTLIPNAPTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 QFGNRDTTAIGDGAVAVGGSNS---------------------------- MAV_4827|M.avium_104 ALAQNVGGAMGYERTAVLLVEP---------------------------- MLBr_01556|M.leprae_Br4923 GPSTAHREELAPPAGQPSEQPG---------------------------- Rv3367|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4149|M.marinum_M -------------------------------------------------- Mb1096c|M.bovis_AF2122/97 -------------------------------------------------- MUL_4381|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2178|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2459|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 LPVPTVASAVLDPTQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTIS TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Rv3367|M.tuberculosis_H37Rv ---------------PDGQDGGLLFGNGGAGYNSAATPGMAGGNGGNAGL MMAR_4149|M.marinum_M ---------------QSGGDGGILYGNGGDGGSGAS--GQIGGTGGSAGL Mb1096c|M.bovis_AF2122/97 ---------------PNGGAGGLLYGNGGNGFSQTT-AGLTGGTGGSAGL MUL_4381|M.ulcerans_Agy99 ---------------GAGEAGGLLFGDGGTGAAATA--TTVAGRGGHAGL Mflv_2178|M.gilvum_PYR-GCK -------------NACNGRDGGLIWGNGGA--------GANGGHGGNAGL Mvan_2459|M.vanbaalenii_PYR-1 -------------SACDGRNGGVLWGNGGN--------GARGGKGGNAGM MSMEG_0868|M.smegmatis_MC2_155 GQYLIGNGINGTADNPNGGTGGLLFGDGGHGYDGSA-AGLAGGNGGNAGL TH_3810|M.thermoresistible__bu ---------------VDGD----------------------GGSGGRTGL MAB_4284c|M.abscessus_ATCC_199 ------------GPIASGQGSTAVNGDVRDSNIINADHGSNVGVDQSQTR MAV_4827|M.avium_104 ----------------DTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQ MLBr_01556|M.leprae_Br4923 ------------VPLPGQQGTPAAPHPGHPGMPTGPHPGPAPKPGGRPPR . Rv3367|M.tuberculosis_H37Rv IG-NGGTGGSGGAG-----AAGGAGGSGGWLYGNGGN------------- MMAR_4149|M.marinum_M IG-AGGTGGAGGLG-----AAGGAGGNGGWLFGQGGA------------- Mb1096c|M.bovis_AF2122/97 IG-NGGNGGAGGAG-----ANGGAGGNGGWLYGSGGN------------- MUL_4381|M.ulcerans_Agy99 IG-TGGAGGAGLAGSSAATMAGGAGGRGGLLLGDGGAGAPGAASFDPNVA Mflv_2178|M.gilvum_PYR-GCK VG-NGGRGGD----------------------ATT--------------- Mvan_2459|M.vanbaalenii_PYR-1 FGGNGGRGGDGYLP-----GQDGGDGGDAGIFASTGN------------- MSMEG_0868|M.smegmatis_MC2_155 FG-NGGNGGVGWAG-----LDGGNGGSGGLLMGIGGA------------- TH_3810|M.thermoresistible__bu FS------------------------------------------------ MAB_4284c|M.abscessus_ATCC_199 VGGDYTNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFN----------- MAV_4827|M.avium_104 LSAMVAGLEKLESLP-----------GGLLLVGSGVD------------- MLBr_01556|M.leprae_Br4923 VGNNPFSSAQSVARPIPRPPAPRPSASPSSMSPRPGG-----------AV .. Rv3367|M.tuberculosis_H37Rv GGIGGN---------------------------------AIVAGGAGGNG MMAR_4149|M.marinum_M GGIGG----------------------------------SGAAGGAGGNG Mb1096c|M.bovis_AF2122/97 GGAGGAG-------------------------PAGAIGAPGVAGGAGGAG MUL_4381|M.ulcerans_Agy99 GGAGGAGGDAGKIGDGGRGGDGGHGATGTAGDATHLEGGRGSDGGAGGKG Mflv_2178|M.gilvum_PYR-GCK ---------------------------------------PGRSGGHGGNG Mvan_2459|M.vanbaalenii_PYR-1 GGDGGHGADGG----------------------------PGTRGGHGGAG MSMEG_0868|M.smegmatis_MC2_155 GGAGGVGADGTS---------------------------AHVDGGTGGTG TH_3810|M.thermoresistible__bu ---------------------------------------KLSRGGDGGDG MAB_4284c|M.abscessus_ATCC_199 -------------------------------------TDRSTNIGSGNTT MAV_4827|M.avium_104 --------------------------------------VAPLKQVLQTTT MLBr_01556|M.leprae_Br4923 GGGGPRPPR-----------------------------TGVPRPGGGRPG Rv3367|M.tuberculosis_H37Rv ------GAGGAAG-------------------------LWGSGGSGGQGG MMAR_4149|M.marinum_M GWL--YGDGGAGGQGGAAAESINDGSPGQGGNGGSAY-LFGNGGSGGQGG Mb1096c|M.bovis_AF2122/97 GTAGLFGNGGVGGVGGDGGQGGNGAGAGASGTKGGD---AGAGGAGGAGG MUL_4381|M.ulcerans_Agy99 GNAGDYGHGGAGGTGGQGGTGGAGLTPGDKGFQGGLGGSGGVGGAGGEGG Mflv_2178|M.gilvum_PYR-GCK ---GRLWGNGGDG---------------------------GNGAPGVLGP Mvan_2459|M.vanbaalenii_PYR-1 GDAGRLHGNGGAG---------------------------GNGGNGGVGV MSMEG_0868|M.smegmatis_MC2_155 GTGGGTGGTGGIG---------------------------GTGG-GLFGL TH_3810|M.thermoresistible__bu ----------------------------------------GLGGNGGHGG MAB_4284c|M.abscessus_ATCC_199 NTEIGSHNQANIGTSTSAG---------------------GSAAVGGNAG MAV_4827|M.avium_104 FLDVSVAEEPETALAR------------------------GAALAAANAP MLBr_01556|M.leprae_Br4923 APVGGRSDAGGGNYR-------------------------GGGVGALPGG * . . . Rv3367|M.tuberculosis_H37Rv --NGLTGNDGVNPAPVTNPALNGAAGDSNIE-----PQTSVLIGTQGGDG MMAR_4149|M.marinum_M --TGLAGADGVN---YSNGTAGPGAWGNNVT-----TSIGDANGGNGGSG Mb1096c|M.bovis_AF2122/97 WIHGHGGAGGDGGAGGAGGQASPGAPGPPSQ-----PGGAGGAGGAGGRG MUL_4381|M.ulcerans_Agy99 LIKGNGGAGGADGIGGTGGIGGDGSRGDTPLGPFNVDGHSGGDGGRGGLG Mflv_2178|M.gilvum_PYR-GCK --AGTAPIPPSSLPAATGTRGDSPPYGYG-----NLVGGDGGTGADGGR- Mvan_2459|M.vanbaalenii_PYR-1 --DSVNPSAGGSAAAGSPNYLGTTGFPYT-----NVVVDNAITGNAGGRG MSMEG_0868|M.smegmatis_MC2_155 --LGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVTVGSETRGGTGGAG TH_3810|M.thermoresistible__bu -------GTGIISLLSLAGNGGNGGNGYR------TTDNNALDGGHGGNG MAB_4284c|M.abscessus_ATCC_199 -LAGNAGLAGNAGLAGNAGLAGNAGLAGNAG-----LAGNAGLAGNAGLA MAV_4827|M.avium_104 LFASSTAALAYAQDPGTGAVDQYSLPDYLYVPVDPEPGDDELAYSAVGEE MLBr_01556|M.leprae_Br4923 GSGGFRGRPGGGGHGGGGRPGQRGGAAGAFGRPGGAPRRGRKSKRQKRQE Rv3367|M.tuberculosis_H37Rv TPGG-AGVNG----------GNGGAGGDANGNPANTSIANAG-------- MMAR_4149|M.marinum_M ADGG-AGVTG----------GTGGVGGFANNEGSGD--ANGG-------- Mb1096c|M.bovis_AF2122/97 GDGGSAGWLS----------GNGGDAGNGGGGGTAGGAGNGGQ------- MUL_4381|M.ulcerans_Agy99 GNGGHGGVGGGHTAGNGFNDGTTGAGGVGGVGGTGGVGGTGGDGLHTALG Mflv_2178|M.gilvum_PYR-GCK YAFGANWSLD----------LPVGGAG-GAGGWANSI---------DGSA Mvan_2459|M.vanbaalenii_PYR-1 KDAAAGTNQS----------GGAGGTGQGVTGFLALP---------HRYN MSMEG_0868|M.smegmatis_MC2_155 GTGGQSTAAG----------PGKGGGGGGGGGGAILIGANGGT--VDGHA TH_3810|M.thermoresistible__bu GNVGFFSLFN-----------LGGAGGWGGSG------------------ MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAG--------LAGNAGLAGNAGLAGNAGLAGNAG-------- MAV_4827|M.avium_104 DAESPTVVIEKLFLPEDSEPRRRPVLLVGSGLAVVGISAVLALEIALAIG MLBr_01556|M.leprae_Br4923 YDSMQAPVVGGVRLPHGNGETIRLARGASLSDFAEKIDANPAALVQALFN . Rv3367|M.tuberculosis_H37Rv AGGNGAAGGDGGAN--GGAGGAGG-------------------------- MMAR_4149|M.marinum_M FGGTGGNGGAPGAS--GGEGGTGG-------------------------- Mb1096c|M.bovis_AF2122/97 FGGDGGTGGTGGTAGAGGNGGRGA-------------------------- MUL_4381|M.ulcerans_Agy99 RQGNGGAGGHGGSGNQGGYGGLSGDES----------------------- Mflv_2178|M.gilvum_PYR-GCK TGGNGGDGGNG--------------------------------------- Mvan_2459|M.vanbaalenii_PYR-1 ISGDGGDGGNG--------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 IGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHST TH_3810|M.thermoresistible__bu VDGVDVVGGNP--------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAGNAGLAGNAG-------------------------- MAV_4827|M.avium_104 IRTTGTVALQPTPN------------------------------------ MLBr_01556|M.leprae_Br4923 LGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDRE------------ Rv3367|M.tuberculosis_H37Rv ----------------QAASAG--SSVGGDGG------------------ MMAR_4149|M.marinum_M ----------------VAIASGG-NAYGGSGG------------------ Mb1096c|M.bovis_AF2122/97 ----------------VLFGHGGNAGHGGAGG------------------ MUL_4381|M.ulcerans_Agy99 --------------SRAAQGATGNDGNGGNGGKGANGNAALGAN------ Mflv_2178|M.gilvum_PYR-GCK -------------------------AFGGRGGN----------------- Mvan_2459|M.vanbaalenii_PYR-1 -------------------------AGGGLGGD----------------- MSMEG_0868|M.smegmatis_MC2_155 GTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIYS TH_3810|M.thermoresistible__bu --------------------------DGGTPG------------------ MAB_4284c|M.abscessus_ATCC_199 --------------LAGNAGLAGNAGLAGNAG------------------ MAV_4827|M.avium_104 ------------------QHLIVPTEQAPAPPP----------------- MLBr_01556|M.leprae_Br4923 --------------LLEPFDLTYGEDQGDEDELQVRPPVVTVMGHVDHGK . Rv3367|M.tuberculosis_H37Rv ----------NGGAGGTG-------------------------------- MMAR_4149|M.marinum_M ----------TGGNGATG-------------------------------- Mb1096c|M.bovis_AF2122/97 ----------NGAAAGAGGE-HVMA------------------------- MUL_4381|M.ulcerans_Agy99 ---------RNGGNGGIGGTGFIGG------------------------- Mflv_2178|M.gilvum_PYR-GCK -----------GGAGGSAYGRG---------------------------- Mvan_2459|M.vanbaalenii_PYR-1 -----------GGDAGLAQEATPT-------------------------- MSMEG_0868|M.smegmatis_MC2_155 GADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTAK TH_3810|M.thermoresistible__bu ----------AHGESHTPG------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------LAGNAAVAGNAAVAG------------------------- MAV_4827|M.avium_104 ----------VQASAPQPKISVPEP------------------------- MLBr_01556|M.leprae_Br4923 TRLLDTIRKANVREAEAGGITQHIG------------------------- . Rv3367|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4149|M.marinum_M -------------------------------------------------- Mb1096c|M.bovis_AF2122/97 -------------------------------------------------- MUL_4381|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2178|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2459|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 AGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAVG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Rv3367|M.tuberculosis_H37Rv ---------------------------TNGHAGGAGG------------- MMAR_4149|M.marinum_M ---------------------------ASGGTGGTGG------------- Mb1096c|M.bovis_AF2122/97 -------------------------TAGKGGTGGVGGDG----------- MUL_4381|M.ulcerans_Agy99 -------------------------NGGNGGGGGAGGNGG---------- Mflv_2178|M.gilvum_PYR-GCK -------------------------GITTGGNGGAGG------------- Mvan_2459|M.vanbaalenii_PYR-1 -------------------------AAAFGGRGGNGG------------- MSMEG_0868|M.smegmatis_MC2_155 GNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGPA TH_3810|M.thermoresistible__bu --------------------------VYTDRQGEDGE------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------NAAVAGNAAVGGVLN---------- MAV_4827|M.avium_104 ------------------------VAAPKPLSPPVAAPLP---------- MLBr_01556|M.leprae_Br4923 --------------------------AYQVGVDLDGSERLITFIDTPGHE . Rv3367|M.tuberculosis_H37Rv -------------------AGGAGGRGG----WLVGNGGNGGNG------ MMAR_4149|M.marinum_M -------------------TGGDGGHGG----LLIGNGGIGGIG------ Mb1096c|M.bovis_AF2122/97 -------------------GGGAGGGGG----LLYGNGGAGGNG------ MUL_4381|M.ulcerans_Agy99 ------------NGAAGVSAGGAGGAGGEGNGGTAGTGGKGGDGGT---- Mflv_2178|M.gilvum_PYR-GCK -------------------HGSTGAAGG--------RGGDGA-------- Mvan_2459|M.vanbaalenii_PYR-1 -------------------TGGTGARGG--------DGGAGG-------- MSMEG_0868|M.smegmatis_MC2_155 GTTIDKGKAAGGNGGDGGFNGTGGATGG--------RGGDGAGASVWK-- TH_3810|M.thermoresistible__bu -------------------DGTGTGIGG--------RGGNGG-------- MAB_4284c|M.abscessus_ATCC_199 -------------------TGVSGAIGG--------SSHVGGAIN----- MAV_4827|M.avium_104 -------------------AAPPPAAPPLPEAPPIPAAPPVVPVPVVV-- MLBr_01556|M.leprae_Br4923 AFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNK . . Rv3367|M.tuberculosis_H37Rv ---------AAGGNGAIGGTGGA-----------GGVPANQGGNSALGTQ MMAR_4149|M.marinum_M ---------GTGGVGGIGGTGGD-----------GGTGGVGGSALNTGSG Mb1096c|M.bovis_AF2122/97 ---------GAGGAGNSGGDGGTG-----LNAALGGNGGGGGVGGNAGAG MUL_4381|M.ulcerans_Agy99 -----ASDDGVGGDGGSGGRGGDGNTRYTPRGNVGGHGGNGGTGGAAGTG Mflv_2178|M.gilvum_PYR-GCK -------SASGGYAV--GGNGGDG-----------------GRGGAGATG Mvan_2459|M.vanbaalenii_PYR-1 -------SVDIGQTVGFGGHGGNG-----------------GAGGTGAAG MSMEG_0868|M.smegmatis_MC2_155 --ANGQHSTGQTDTGGNGGRGGDGG--------TFVNAGANGNGGAGGAG TH_3810|M.thermoresistible__bu ---------SSSGTHPMAEDGEH-------------------VKALDGRP MAB_4284c|M.abscessus_ATCC_199 --------ESLGGSGSVGGSTAVGG---------------GAHTGVGGGV MAV_4827|M.avium_104 --PPVPVPVPVRIPVPDPVSPPQLLAPPRLSVPQPVQPPVRVPQPPSPPQ MLBr_01556|M.leprae_Br4923 IDKEGADPAKIRGQLTEYGLVAEDFGGDTMFIDISAKVGTNIEALLEAVL Rv3367|M.tuberculosis_H37Rv PVGGD-GGDGGNGGTGGTGGRGGDGGSGGAGG-------------ASGWL MMAR_4149|M.marinum_M VADANIGGDGGDAGTGGDGGTGGVGGVGGSGG-------------AGGLL Mb1096c|M.bovis_AF2122/97 GTGGSAGWLSGNGGAGGSGGSAGAGGAGGKGGDTPNGLAINPGIGGNGGD MUL_4381|M.ulcerans_Agy99 GHGGN-GGDGGNGGINANGAAGGAGGNGGAGGGSTLLAN------GHGGA Mflv_2178|M.gilvum_PYR-GCK ----GTGGTGGAGGDGGRGG--LLGGHGGKG--------------GNAGL Mvan_2459|M.vanbaalenii_PYR-1 ----ATGAAGGNGGAGGRSG--SRTGNGGAG--------------GAAGN MSMEG_0868|M.smegmatis_MC2_155 GVSEGEGGTGGHGGDGGRGGDGALGGNGGTGGVGL----------GNGGK TH_3810|M.thermoresistible__bu GLDGGNGSHGGNGGHGGRGGFLGIGGSGGWG-----------------GH MAB_4284c|M.abscessus_ATCC_199 STGVGVGSHVGGGISESLGGSGSVGGSTAVGG-------------GAHTG MAV_4827|M.avium_104 VGGTVPQSPPQHQTPPGEGTPPKPDGPGNYGG-------------GHVPT MLBr_01556|M.leprae_Br4923 LTADAALDLRANSGMEAQGVAIEAHLDRGRGPVATVLVQRGTLRIGDSVV . . * Rv3367|M.tuberculosis_H37Rv MGNGG--------NGGNGG--------TGGSGGVGGNGGIG--------- MMAR_4149|M.marinum_M FGNGG--------DGGAGG--------DGGVGGTGGIGGAG--------- Mb1096c|M.bovis_AF2122/97 TGNAG--------NGGNGGS-AARLFGGGGAGGAGGTGSTA--------- MUL_4381|M.ulcerans_Agy99 GGNGG--------NGGIGGENASNRGATGGAGGVGGIGGAGS-----LSI Mflv_2178|M.gilvum_PYR-GCK GGNGG--------TGGTG-----------GVGGDGGVGGG----ILTATG Mvan_2459|M.vanbaalenii_PYR-1 GGSGG--------NGATG-----------GDGGSGGVGGA----DVSDPG MSMEG_0868|M.smegmatis_MC2_155 GGNGG--------NGGNGGT--YVDPSHTGAGGNGGNGGAGRIRVNNGTA TH_3810|M.thermoresistible__bu GGNGG--------DTDADG----------GNGGDGGNGGSA--------- MAB_4284c|M.abscessus_ATCC_199 VGGGV--------STGVGVGSHVGGGISESLGGSGSVGGST--------- MAV_4827|M.avium_104 PGAGG--------SGGSGGG----HVPTPGAGGSGGSGGGHVP------- MLBr_01556|M.leprae_Br4923 AGDAYGRVRRMVDEHGVDIEAALPSSPVQVIGFTSVPGAGDNFLVVDEDR * . . * . *. Rv3367|M.tuberculosis_H37Rv ------GDGAGGGNATSTSS------------------------------ MMAR_4149|M.marinum_M ------GNGGVGGDGSSSG------------------------------- Mb1096c|M.bovis_AF2122/97 ------GSGGSGGTNPPTG------------------------------- MUL_4381|M.ulcerans_Agy99 RGGGYGGLGGNGGTGGAGGA------------------------------ Mflv_2178|M.gilvum_PYR-GCK ----VVGAGGSGGAG----------------------------------- Mvan_2459|M.vanbaalenii_PYR-1 SGPVTAGTGGNGGSG----------------------------------- MSMEG_0868|M.smegmatis_MC2_155 TGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGD TH_3810|M.thermoresistible__bu ------GRGGTGGLR----------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----AVGGGAHTGVGGGVNTG----------------------------- MAV_4827|M.avium_104 ----TPGTGGPGGTGG---------------------------------- MLBr_01556|M.leprae_Br4923 IARQIADRRSARKRNALAARSRKRISLEDLDSALKETSQLN--------- . . Rv3367|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4149|M.marinum_M -------------------------------------------------- Mb1096c|M.bovis_AF2122/97 -------------------------------------------------- MUL_4381|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2178|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2459|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Rv3367|M.tuberculosis_H37Rv ---------------IPFDAHGGNGGAGGDAGHGGTGG------------ MMAR_4149|M.marinum_M ---------------------TGAGGSGGDATDGGTGG------------ Mb1096c|M.bovis_AF2122/97 -----------------LQAAGGNGGSGHAGGHGGNGGGAGL-------- MUL_4381|M.ulcerans_Agy99 ---------------GANETYGGSGGSGGAAGNGGVGGLNGVGGNGGVGG Mflv_2178|M.gilvum_PYR-GCK -------------------GTGGRGGDGGDGGQAGRGG------------ Mvan_2459|M.vanbaalenii_PYR-1 -------------------GAGGAGGDGGAGGLGGKGG------------ MSMEG_0868|M.smegmatis_MC2_155 NGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAAN TH_3810|M.thermoresistible__bu -------------------GVFGINGGNGRAGLGGRGX------------ MAB_4284c|M.abscessus_ATCC_199 ------------------VGVGSHVGGGISESLGGSGS------------ MAV_4827|M.avium_104 -------------------SGGGHVPTPGAGTPGGSGGG----------- MLBr_01556|M.leprae_Br4923 -----------------LILKGDNAGTVEALEEALMGIQVDDEVALR--- . . * Rv3367|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4149|M.marinum_M -------------------------------------------------- Mb1096c|M.bovis_AF2122/97 -------------------------------------------------- MUL_4381|M.ulcerans_Agy99 HGGNGQFNGGNGGKGGVG-------------------------------- Mflv_2178|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2459|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Rv3367|M.tuberculosis_H37Rv ------------------------------------DGGDGGHAGTGGRG MMAR_4149|M.marinum_M ------------------------------------DGGSGGGFGTGGAG Mb1096c|M.bovis_AF2122/97 -----------------------------------LGGGTGGNGGGGGQG MUL_4381|M.ulcerans_Agy99 -----------------------------GTAGAGTTAGNGGHGGTGGTG Mflv_2178|M.gilvum_PYR-GCK ------------------------------------AGGLAGRSGADGEA Mvan_2459|M.vanbaalenii_PYR-1 ------------------------------------AGSSEGSAGADAAN MSMEG_0868|M.smegmatis_MC2_155 KGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGA TH_3810|M.thermoresistible__bu -------------------------------------XXXGGGVGAAVRS MAB_4284c|M.abscessus_ATCC_199 ------------------------------------VGGSTAVGGGAHTS MAV_4827|M.avium_104 ------------------------------------HLPFPGAGSTPGGS MLBr_01556|M.leprae_Br4923 ----------------------------------VIDRGVGGITETNVNL Rv3367|M.tuberculosis_H37Rv GLL----------------------------------------------- MMAR_4149|M.marinum_M GTG----------------------------------------------- Mb1096c|M.bovis_AF2122/97 GLG----------------------------------------------- MUL_4381|M.ulcerans_Agy99 GDGQTAAGV----------------------------------------- Mflv_2178|M.gilvum_PYR-GCK G------------------------------------------------- Mvan_2459|M.vanbaalenii_PYR-1 G------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGS TH_3810|M.thermoresistible__bu GNG----------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AIN----------------------------------------------- MAV_4827|M.avium_104 GGG----------------------------------------------- MLBr_01556|M.leprae_Br4923 ASAS---------------------------------------------- . Rv3367|M.tuberculosis_H37Rv --AGQHANSGNGGGGGTGGAGGTHGTPG---------------------S MMAR_4149|M.marinum_M --GWLIGHSGTNGIGGTGGAGGAGAVGG---------------------D Mb1096c|M.bovis_AF2122/97 --AAAGGVDGNGGNGGNGGKGGDAQLVG---------------------D MUL_4381|M.ulcerans_Agy99 --GGSGGTGGNGGRGGTGGAGGTGVTGG---------------------D Mflv_2178|M.gilvum_PYR-GCK ----DAGTGGRGGAGGSGGKGGISG------------------------T Mvan_2459|M.vanbaalenii_PYR-1 ----ATGVGGSGGAGGRGGTGGASGDGA---------------------S MSMEG_0868|M.smegmatis_MC2_155 KIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNT TH_3810|M.thermoresistible__bu ----VFSGGGGTPSAGFGVPTTIQFPAG---------------------S MAB_4284c|M.abscessus_ATCC_199 -----DALGGSGSVGGSTAVGGGAHTSAIN----------------ESMN MAV_4827|M.avium_104 ---HLPTPGAGTPGGGLGGFGGGHAPAP---------------------G MLBr_01556|M.leprae_Br4923 ---DAIIIGFNVRAEGKATELASREGVEIRYYLVIYQAIDDIEKALRGML * Rv3367|M.tuberculosis_H37Rv GNAGGTG-TGNADS--------TNGGPGSDGLGGD------AFNGSRGTD MMAR_4149|M.marinum_M GGVGGD--PGVGTT--------YNGISGHNGVQG-----------GTGAD Mb1096c|M.bovis_AF2122/97 GGNGGNGGKGGAGL--------IAGLDGAGGAGG-------TRGLIFGNA MUL_4381|M.ulcerans_Agy99 GGRGGSGGAGGDGAGTCAGNGGNGGLGGAGGNGGHGGTSTLNEQQVVGSD Mflv_2178|M.gilvum_PYR-GCK GTPGGAGQSGQSAT---------GRSGGAGGEGG-----------AGGAG Mvan_2459|M.vanbaalenii_PYR-1 GGSGGAGKPGTGPT---------GSKGGAGGSGG-----------SGGSG MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGGDGSEPG---------PGGNGAGGAGG-----------NGGTG TH_3810|M.thermoresistible__bu CTSRAVSREGIMPS-----------SRAASARAG-----------AACAS MAB_4284c|M.abscessus_ATCC_199 SSINASHSSSMNES--------FGSSMGSHGAAGTG------FEAQGHAQ MAV_4827|M.avium_104 GGLGGGGGHAPAPG---------GGLGGFGGGHS-----------GGGLG MLBr_01556|M.leprae_Br4923 KPIYEENQLGRAEIRALFRSSKVGIIAGCIISSGVVRRNAKVRLLRDNIV . . . Rv3367|M.tuberculosis_H37Rv GNPG---------------------------------------------- MMAR_4149|M.marinum_M GAAG---------------------------------------------- Mb1096c|M.bovis_AF2122/97 GTPGQ--------------------------------------------- MUL_4381|M.ulcerans_Agy99 GGPGEGPGPNRSGGEGGSRGRPGGR------------------------- Mflv_2178|M.gilvum_PYR-GCK GTDD---------------------------------------------- Mvan_2459|M.vanbaalenii_PYR-1 GQAD---------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP-------------- TH_3810|M.thermoresistible__bu STSRSRRSFCCSRA------------------------------------ MAB_4284c|M.abscessus_ATCC_199 GHASETAHTTLPGAEHH--------------------------------- MAV_4827|M.avium_104 GLGGGHK------------------------------------------- MLBr_01556|M.leprae_Br4923 VTDNLTVTSLRREKDDVTEVREGFECGMTLGYSDIKEGDVIESYELVEKQ Rv3367|M.tuberculosis_H37Rv -- MMAR_4149|M.marinum_M -- Mb1096c|M.bovis_AF2122/97 -- MUL_4381|M.ulcerans_Agy99 -- Mflv_2178|M.gilvum_PYR-GCK -- Mvan_2459|M.vanbaalenii_PYR-1 -- MSMEG_0868|M.smegmatis_MC2_155 -- TH_3810|M.thermoresistible__bu -- MAB_4284c|M.abscessus_ATCC_199 -- MAV_4827|M.avium_104 -- MLBr_01556|M.leprae_Br4923 RA