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VDSPDVRSLPLAPRNPLPYWQQLKALKTLHVGSEALRDAGGSVTRIWLGPKRLVPPMVMVTSPQGARDVL GRSGALSDRGTLPLLKDLRRAIGESVLNLPHDTWLPRRRTLQPIFTKQRVAGFAGHMSEAANHILLGWPD GAEVDLNAASHALVLRVVGHSVFGLDLQDKADVITTGVTLAAKWAADRSARPVRAPHWLPTPARRRARGA YDAMYKIAADMLAACRADPNREAPLIRALIDATDPNTGESLSDQQICDEMVYFMILGEDTTSTVLTYALW ALGRHSQLQDRVAAEAAELGDRPLTPADVPRLGYTIQVLQEAMRLCPPGPTVARRAMQDIEVDGYRVQAG TYCLVGVYAMHRDPALWDDPLAFDPDRFAPKKSKGRDRWQYLPFGGGGRSCLGDHFAMLEASLALATIIR EAEIHSLDGDFPVAIPLPIVPAGPIRARVNQRRPSQEVCTTTLSDSSASSSAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0852 | cyp185A4 | - | 100% (474) | cytochrome P450 185A4 Cyp185A4 |
| M. marinum M | MMAR_0283 | cyp274A1 | 2e-50 | 29.74% (427) | cytochrome P450 274A1 Cyp274A1 |
| M. marinum M | MMAR_0281 | cyp183B1 | 2e-44 | 29.89% (445) | cytochrome P450 183B1 Cyp183B1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1429c | cyp132 | 3e-33 | 28.32% (346) | cytochrome P450 132 |
| M. gilvum PYR-GCK | Mflv_0056 | - | 1e-142 | 54.12% (449) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1394c | cyp132 | 5e-33 | 28.32% (346) | cytochrome P450 132 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-09 | 25.13% (199) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1426 | - | 2e-40 | 30.73% (397) | putative cytochrome P450 |
| M. avium 104 | MAV_3927 | - | 2e-32 | 25.95% (370) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_0822 | - | 1e-150 | 55.56% (450) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3255 | - | 1e-150 | 57.02% (449) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 0.0 | 97.88% (471) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_0245 | - | 1e-158 | 59.24% (449) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1429c|M.bovis_AF2122/97 -MATATTQRPLKGPAKRMS--------------------------TWTMT
Rv1394c|M.tuberculosis_H37Rv -MATATTQRPLKGPAKRMS--------------------------TWTMT
MMAR_0852|M.marinum_M ---MVDSPDVRSLPLAPRN--------------------------PLPYW
MUL_0604|M.ulcerans_Agy99 ---MVDPPDIRSLPLAPRN--------------------------PLPYW
Mflv_0056|M.gilvum_PYR-GCK MVAGTEPG-VGHLPLAPKN--------------------------PLPYR
TH_3255|M.thermoresistible__bu MVVTTERADVATLPPAPRN--------------------------PLPYW
Mvan_0245|M.vanbaalenii_PYR-1 MVGTVEREDLGALPLAPRN--------------------------PLPYR
MSMEG_0822|M.smegmatis_MC2_155 MVETASPP-LTELPLAPRN--------------------------TLPCR
MAB_1426|M.abscessus_ATCC_1997 MSASALQPEPLSAPVEVAAGECPVNHDLYPGGPTFLRWHHTRVGYLKSWR
MAV_3927|M.avium_104 MTATISTPQYLLDQARRRFTPTLNTIPGMG----------AIEKRLLAHE
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMG-----------------TNPPSLVE
Mb1429c|M.bovis_AF2122/97 REAITIGFDAGDGFLGRLRGSDITRFR-----------------------
Rv1394c|M.tuberculosis_H37Rv REAITIGFDAGDGFLGRLRGSDITRFR-----------------------
MMAR_0852|M.marinum_M QQLKALKTLHVGSEALRDAGGSVTRIW-----------------------
MUL_0604|M.ulcerans_Agy99 QQLKALKTLHVGSEALRDAGGSVTRIW-----------------------
Mflv_0056|M.gilvum_PYR-GCK RLLTLVRALDTGQLQVRAAGGPITRVQ-----------------------
TH_3255|M.thermoresistible__bu RQVRAVRSFHTGQELLRDAGGPVK--------------------------
Mvan_0245|M.vanbaalenii_PYR-1 QQVRAIRTFHTGLETLRDAGGPVTRLK-----------------------
MSMEG_0822|M.smegmatis_MC2_155 EQIRCLRSFIDGMQRLRDVGGPVTRIV-----------------------
MAB_1426|M.abscessus_ATCC_1997 LALGAVWSTYRHTISEYLADLPGQDDV-----------------------
MAV_3927|M.avium_104 WQTKVLAEPPAGSGLKPVLGDAGLPILGHIIELFRGGPDYALFLYRNHGP
MLBr_02088|M.leprae_Br4923 AQMLLLRLIDPGTRADPFPVYRALIDYG--------------------PM
:
Mb1429c|M.bovis_AF2122/97 -CAGRRFVS----ISHPDYVDHVLHEAR---LKYVK--SDEYGPIRATAG
Rv1394c|M.tuberculosis_H37Rv -CAGRRFVS----ISHPDYVDHVLHEAR---LKYVK--SDEYGPIRATAG
MMAR_0852|M.marinum_M -LGPKRLVPPMVMVTSPQGARDVLGRSG---ALSDRGTLPLLKDLRRAIG
MUL_0604|M.ulcerans_Agy99 -LGPKRLVPPMVMVTSPQGARDVLGRSG---ALSDRGTLPLLKDLRRAIG
Mflv_0056|M.gilvum_PYR-GCK -VAPRWLFPPFVAVFSPRGVRDVLGRND---AFSER--CIVHEEVRDMAG
TH_3255|M.thermoresistible__bu -----WAIPPIVLVTSPAGIRDVLNRRD---ALSER--CQVHHEVRHLGG
Mvan_0245|M.vanbaalenii_PYR-1 -LAPKWLMPPMVVATSPQGARDILARGG---GHIDK--TRVHHEMRRLLG
MSMEG_0822|M.smegmatis_MC2_155 -LGPRWLVPPALLVTSPQGAHDVLSLPD---AVADRGGSRNMRQLQRLMG
MAB_1426|M.abscessus_ATCC_1997 -IVARAPMRKAVIVRNPELARHVLVANQ---DNYIK--SAEYDLLAVGFG
MAV_3927|M.avium_104 LIYLDSPIMPAVTALGPDATQAVFSNRN---KDYSQ--KGWHPVIGPFFN
MLBr_02088|M.leprae_Br4923 QLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQAIAAGAEPRPFYA
: :
Mb1429c|M.bovis_AF2122/97 LNLLTDEGD-SWARHRGALNSTFARRHLRGLVGLMIDPIADVTAALVP--
Rv1394c|M.tuberculosis_H37Rv LNLLTDEGD-SWARHRGALNSTFARRHLRGLVGLMIDPIADVTAARVP--
MMAR_0852|M.marinum_M ESVLNLPHD-TWLPRRRTLQPIFTKQRVAGFAGHMSEAANHILLGWPD--
MUL_0604|M.ulcerans_Agy99 ESVLNLPHD-TWLPRRRTLQPIFTKQRVAGFAGHMSEAANHILLGWPD--
Mflv_0056|M.gilvum_PYR-GCK DSLFVLPNE-PWRPRKRALQPVFTPQNVRRFGGHMSRAAEVFVDAWRD--
TH_3255|M.thermoresistible__bu DSLFVLPTD-PWRARRRALAPVFTPTAVRSYGGYMSEAAQRVADGWQA--
Mvan_0245|M.vanbaalenii_PYR-1 ANLFDLTHE-PWLPRRRALQPIFTKQHVREFAGHMATAAQTVADSWAD--
MSMEG_0822|M.smegmatis_MC2_155 GNLLDLPHD-RWLPRRRTLQPLFTKKHVPRFAGHMAAAAQSVAVSWAD--
MAB_1426|M.abscessus_ATCC_1997 RGLVTDLNEGLWNRNRRLVQPIFAKRQVDLFAPQMAEAAARTISRWDELY
MAV_3927|M.avium_104 RGLMMLDFD-EHMYHRRIMQEAFTRSRLTGYVEHIDRVATDIVADWPTN-
MLBr_02088|M.leprae_Br4923 SSFMFLDPP-DHTRLRKLVSKAFAPKVVQALEGDIAALVDSLLDKGAA--
... : : *: : :
Mb1429c|M.bovis_AF2122/97 --GAQFDMHQSMVETTLRVVANALFSQDFGPLVQSMHDLATRGLRRAEKL
Rv1394c|M.tuberculosis_H37Rv --GAQFDMHQSMVETTLRVVANALFSQDFGPLVQSMHDLATRGLRRAEKL
MMAR_0852|M.marinum_M --GAEVDLNAASHALVLRVVGHSVFGLDLQDKADVITTGVT---------
MUL_0604|M.ulcerans_Agy99 --GAEVDLNAASHALVLRVVGHSVFGLDLQDKADVITTGVT---------
Mflv_0056|M.gilvum_PYR-GCK --GGDVDLDLECRRITMQSLGRSVLGVDLNESADVIAEHMH---------
TH_3255|M.thermoresistible__bu --AREVDLDAECRRLTMRSLGRSVLGLDINERADAISEPMH---------
Mvan_0245|M.vanbaalenii_PYR-1 --GTELDLDTECRKLTLRALGRSVLGLDLDEHSDAIAEPLR---------
MSMEG_0822|M.smegmatis_MC2_155 --GATVDLDRACRALTLRALGRSVFGVDLDQRAEDVGPALR---------
MAB_1426|M.abscessus_ATCC_1997 AEGKPVDITAEMNYLTMDIVAQTMFGIDLSGDMAERMRIYFARLLKLFGV
MAV_3927|M.avium_104 --DARFLFHPAMKELTLDIASLVFMGHEPGTDHDLVTKVNQ---------
MLBr_02088|M.leprae_Br4923 --AGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFG--------------
. . .:.
Mb1429c|M.bovis_AF2122/97 ERLGLWGLMPRTVYDTLIWC-------------IYSGVHLPPPLR-EMQE
Rv1394c|M.tuberculosis_H37Rv ERLGLWGLMPRTVYDTLIWC-------------IYSGVHLPPPLR-EMQE
MMAR_0852|M.marinum_M -------LAAKWAADRSARP-------------VRAPHWLPTPARRRARG
MUL_0604|M.ulcerans_Agy99 -------LAAKWAADRSARP-------------VRAPHWLPTPARPRARG
Mflv_0056|M.gilvum_PYR-GCK -------VASSYTADRALRP-------------VRAPRWLPTPARRRAAH
TH_3255|M.thermoresistible__bu -------IASSYTADRALRP-------------VRAPRWLPTPARRRARA
Mvan_0245|M.vanbaalenii_PYR-1 -------TALEYIADRALQP-------------ISAPRWLPTPARRRARA
MSMEG_0822|M.smegmatis_MC2_155 -------TSLSWVADRASRP-------------VNLPQWVPTRGQRKARA
MAB_1426|M.abscessus_ATCC_1997 GFIVGAAPPLRWVVDKLAAHGPDELSSHTPRLAIRALRIGASVAAPRTMK
MAV_3927|M.avium_104 ----------AFTTTTRAGG-------------AIIRQPIPPFKWWRGLR
MLBr_02088|M.leprae_Br4923 --------RVSALLVQSVDP-------------FITITGEPPEATEERLR
.. .
Mb1429c|M.bovis_AF2122/97 ITLTLDRAINSVIDRRLAE-PTNSADLLNVLLSAD----GGIWPRQRVRD
Rv1394c|M.tuberculosis_H37Rv ITLTLDRAINSVIDRRLAE-PTNSADLLNVLLSAD----GGIWPRQRVRD
MMAR_0852|M.marinum_M AYDAMYKIAADMLAACRAD-PNREAPLIRALIDATDPNTGESLSDQQICD
MUL_0604|M.ulcerans_Agy99 AYDAMYKIAADMLAACRAD-PSREAPLITALIDATGPNTGESLSDQQICD
Mflv_0056|M.gilvum_PYR-GCK AVAEMRQVAADMLQVCRDD-PDRDAPLVRALMDARDPETGMALSDDDICN
TH_3255|M.thermoresistible__bu AVATMRRITDEMLQACRAD-PDRDAPLVHALIRATDPETGRGLSDEDICN
Mvan_0245|M.vanbaalenii_PYR-1 ASSTLHKLADKILQACRTD-PTRDAPLVQALIAASDPATGRPLSDDEIRD
MSMEG_0822|M.smegmatis_MC2_155 GNATLHRLAAEILADVRAD-PDRDAPLVRALLEARDPETGRGLTDDQICD
MAB_1426|M.abscessus_ATCC_1997 GLRWVERTIDQLIADHRSGRIARQDNLLALLMAAEDPETGAKYTDLEIRD
MAV_3927|M.avium_104 ARQLLEDYFSERVKERRNA---TGNDMLTVLCHTED-DDGNSFTDDDIVN
MLBr_02088|M.leprae_Br4923 AGVWLRDYLEQLVKCRRGT---PGEDLISRLIELDE--SGDQLTEEEIIA
: . : :: * * . :
Mb1429c|M.bovis_AF2122/97 EALTFMLAGHETTANAMSWFWYLMALNPQARDHMLTELDDVLGMRRPTAD
Rv1394c|M.tuberculosis_H37Rv EALTFMLAGHETTANAMSWFWYLMALNPQARDHMLTELDDVLGMRRPTAD
MMAR_0852|M.marinum_M EMVYFMILGEDTTSTVLTYALWALGRHSQLQDRVAAEAAELG-DRPLTPA
MUL_0604|M.ulcerans_Agy99 EMVYFMILGEDTTSTVLTYALWALGQHCQLQDRLAAEAAELG-DRPLTPA
Mflv_0056|M.gilvum_PYR-GCK DLLIFMLAGHDTTATALTYALWVLGHHPDVQDRVAAEAAALG-RRELEPG
TH_3255|M.thermoresistible__bu DLLIFMLAGHDTTATALTYALWALGHHPEIQDRVAAEVAELP-DREITPH
Mvan_0245|M.vanbaalenii_PYR-1 ELIVFMLAGHDTTATTLTYAMWALGHHHDVQDRVRAEVVGIG-DRELTPE
MSMEG_0822|M.smegmatis_MC2_155 ELVLFMLAGHDTTSTTLCYSLWALGHHPDIQERVYAEVAALG-DRELTTD
MAB_1426|M.abscessus_ATCC_1997 ELMTFLGAGFETTAAALAWTWYLLSRNPDARAKLGQEVDRVLGGRQPTAA
MAV_3927|M.avium_104 HMIFLMMAAHDTSTSTTTTMVYNMAAHPEWQERAREESTRLG-DGPLDIE
MLBr_02088|M.leprae_Br4923 TCGLLLVAGHETTVNLIANAVLAMLRNPSQWKALSSNPQRAP--------
:: . :*: : : . :
Mb1429c|M.bovis_AF2122/97 DLGKLAWTTACLQESQRYFSSVWIIAREAVDDDIIDGHRIRRGTTVVIPI
Rv1394c|M.tuberculosis_H37Rv DLGKLAWTTACLQESQRYFSSVWIIAREAVDDDIIDGHRIRRGTTVVIPI
MMAR_0852|M.marinum_M DVPRLGYTIQVLQEAMRLCPPGPTVARRAMQDIEVDGYRVQAGTYCLVGV
MUL_0604|M.ulcerans_Agy99 DVPRLGYTIQVLQEAMRLRPPGPTVARRAMQDIEVDGYRVQAGTYCLVGV
Mflv_0056|M.gilvum_PYR-GCK DVPHLKYTTQVLLEALRLCPPAAGVGRMAVRDIDVDGHRVQAGTLVAVGI
TH_3255|M.thermoresistible__bu DVPRLGYTVQVLRESLRLCPPAAGVGRLAMSDLAVDGYRVEAGTLLAVGI
Mvan_0245|M.vanbaalenii_PYR-1 DVPALGYTIQVLHEALRLCPPAAATARMAMRDVEVDGYRIEAGSMMAVGI
MSMEG_0822|M.smegmatis_MC2_155 DVPQLTYTMRVLHEALRLCPPGSGTMRMLNEEMTVDGYRVEAGTVAIVNF
MAB_1426|M.abscessus_ATCC_1997 DVDNLPWTAAVLNEAMRVYPPILGLARTAKADDVLGDYPISAGTTVMVLI
MAV_3927|M.avium_104 ALEKLETLELIMNESLRMVTPLPFNMRQAVRDTELLGHYIPAGTNITIWP
MLBr_02088|M.leprae_Br4923 ---------LVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLL
: *: * .. * : : : * :
Mb1429c|M.bovis_AF2122/97 HHIHHDPRWWPDPDRFDPGRFLR-CPTD-RPRCAYLPFGGGRRICIGQSF
Rv1394c|M.tuberculosis_H37Rv HHIHHDPRWWPDPDRFDPGRFLR-CPTD-RPRCAYLPFGGGRRICIGQSF
MMAR_0852|M.marinum_M YAMHRDPALWDDPLAFDPDRFAP-KKSKGRDRWQYLPFGGGGRSCLGDHF
MUL_0604|M.ulcerans_Agy99 YAMHRDPALWDDPLAFDPDRFAP-KKSKGRDRWQYLPFGGGGRSCLGDHF
Mflv_0056|M.gilvum_PYR-GCK YALHRDPEIWPDPDRFDPDRFSP-EQTAQRDRWHFLPFAGGARSCIGEHF
TH_3255|M.thermoresistible__bu QAIHRDPSLWPDPMVFDPDRFAP-ERFKAMDRWQFVPFIGGPRSCIGEHF
Mvan_0245|M.vanbaalenii_PYR-1 YALHRDPALWERPLVFDPDRFSA-QNSGGRDRWQYLPFGAGPRSCIGDHF
MSMEG_0822|M.smegmatis_MC2_155 YAMHRSPTLWDAPERFDPDRFSP-ERSAGRNRWQYLPFGGGPRSCIGDHF
MAB_1426|M.abscessus_ATCC_1997 DSIHHNERVWDDAKTFDPARFLK-ENLQPEQRKAHMPFGAGKRMCVASGF
MAV_3927|M.avium_104 GMNHRLPELWTDPDKFDPERFAEPRAEHKKHRYAFAPFGGGAHKCIGMVF
MLBr_02088|M.leprae_Br4923 AAANRDPAVYSRPDEFDPDRPSS----------RHLAFAVGSHFCLGAAL
:: : . *** * . .* * : *:. :
Mb1429c|M.bovis_AF2122/97 ALMEMVLMAAIMSQHF-TFDLAPG--YHVELEATLTLRPKHGVHVIGRRR
Rv1394c|M.tuberculosis_H37Rv ALMEMVLMAAIMSQHF-TFDLAPG--YHVELEATLTLRPKHGVHVIGRRR
MMAR_0852|M.marinum_M AMLEASLALATIIREA-EIHSLDGD-FPVAIPLPIVPAGPIRARVNQRRP
MUL_0604|M.ulcerans_Agy99 AMLEASLALATIIREA-EIHSLDGD-FPVAIPLPIVPAGPIRARVNQRRP
Mflv_0056|M.gilvum_PYR-GCK ARLETTLALATIVRSM-RVTSSDND-FPVDVPFTTVAHGPIPAHLTPR--
TH_3255|M.thermoresistible__bu AMLESTLAIATLIRSV-RIRSLDDD-FPVEVPFTTVARGPIRAVVSARR-
Mvan_0245|M.vanbaalenii_PYR-1 AMLEATLALATIIRSA-EIRSSDPH-FPMIVPFTTVAAEPIRARVKSVNR
MSMEG_0822|M.smegmatis_MC2_155 AMLEATLALATVIRAV-SVESQNTD-LPVETPFTVIAAAPVPARVTRR--
MAB_1426|M.abscessus_ATCC_1997 ANLEAIIGIAALAQNY-ELDLLPGQQPRREVTFTGGPEGEILMRLRKRHP
MAV_3927|M.avium_104 GQLEVKTVVHRLLRRY-RLELARPG-YQPRWDYGGMPIPMDGMPIVLRPL
MLBr_02088|M.leprae_Br4923 ARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV-------
. :* : .
Mb1429c|M.bovis_AF2122/97 -------------------
Rv1394c|M.tuberculosis_H37Rv -------------------
MMAR_0852|M.marinum_M SQEVCTTTLSDSSASSSAS
MUL_0604|M.ulcerans_Agy99 SQEVCTTTLSDSSASS---
Mflv_0056|M.gilvum_PYR-GCK -------------------
TH_3255|M.thermoresistible__bu -------------------
Mvan_0245|M.vanbaalenii_PYR-1 IPAADSGGR----------
MSMEG_0822|M.smegmatis_MC2_155 -------------------
MAB_1426|M.abscessus_ATCC_1997 -------------------
MAV_3927|M.avium_104 -------------------
MLBr_02088|M.leprae_Br4923 -------------------