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VSASALQPEPLSAPVEVAAGECPVNHDLYPGGPTFLRWHHTRVGYLKSWRLALGAVWSTYRHTISEYLAD LPGQDDVIVARAPMRKAVIVRNPELARHVLVANQDNYIKSAEYDLLAVGFGRGLVTDLNEGLWNRNRRLV QPIFAKRQVDLFAPQMAEAAARTISRWDELYAEGKPVDITAEMNYLTMDIVAQTMFGIDLSGDMAERMRI YFARLLKLFGVGFIVGAAPPLRWVVDKLAAHGPDELSSHTPRLAIRALRIGASVAAPRTMKGLRWVERTI DQLIADHRSGRIARQDNLLALLMAAEDPETGAKYTDLEIRDELMTFLGAGFETTAAALAWTWYLLSRNPD ARAKLGQEVDRVLGGRQPTAADVDNLPWTAAVLNEAMRVYPPILGLARTAKADDVLGDYPISAGTTVMVL IDSIHHNERVWDDAKTFDPARFLKENLQPEQRKAHMPFGAGKRMCVASGFANLEAIIGIAALAQNYELDL LPGQQPRREVTFTGGPEGEILMRLRKRHP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1426 | - | - | 100% (519) | putative cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_3275 | - | 9e-36 | 27.78% (432) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_2151c | - | 2e-35 | 28.15% (444) | putative cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1429c | cyp132 | 1e-51 | 31.74% (460) | cytochrome P450 132 |
| M. gilvum PYR-GCK | Mflv_0056 | - | 3e-37 | 28.72% (390) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1394c | cyp132 | 1e-51 | 31.74% (460) | cytochrome P450 132 |
| M. leprae Br4923 | MLBr_02088 | - | 7e-11 | 24.09% (220) | putative cytochrome p450 |
| M. marinum M | MMAR_0281 | cyp183B1 | 3e-46 | 29.69% (448) | cytochrome P450 183B1 Cyp183B1 |
| M. avium 104 | MAV_5160 | - | 2e-28 | 27.12% (472) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_0968 | - | 6e-44 | 29.55% (440) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3255 | - | 1e-37 | 29.43% (384) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 6e-40 | 29.87% (395) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_0245 | - | 1e-41 | 30.22% (407) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0056|M.gilvum_PYR-GCK MV------------------AGTEPGVGHLPLAPKNPLPYRRLLTLVR--
MSMEG_0968|M.smegmatis_MC2_155 MVSDVPAVTAPPGRSADASGANAKPDTGALPLAPRNPLSLRQMARAVR--
TH_3255|M.thermoresistible__bu MVV-----------------TTERADVATLPPAPRNPLPYWRQVRAVR--
Mvan_0245|M.vanbaalenii_PYR-1 MVG-----------------TVEREDLGALPLAPRNPLPYRQQVRAIR--
MUL_0604|M.ulcerans_Agy99 MVD--------------------PPDIRSLPLAPRNPLPYWQQLKALK--
Mb1429c|M.bovis_AF2122/97 ---------------------MATATTQRPLKGPAKRMSTWTMTREAITI
Rv1394c|M.tuberculosis_H37Rv ---------------------MATATTQRPLKGPAKRMSTWTMTREAITI
MAB_1426|M.abscessus_ATCC_1997 -MSASALQPEPLSAPVEVAAGECPVNHDLYPGGPTFLRWHHTRVGYLKSW
MMAR_0281|M.marinum_M -------------------------MPTSIPIAPAALPLLGHTLPLLR--
MAV_5160|M.avium_104 -----------------------MSEVATAPLAAVHLPPAVRGPKLLQGI
MLBr_02088|M.leprae_Br4923 --------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLI
..
Mflv_0056|M.gilvum_PYR-GCK ALDTG-------QLQVRAAGG-PITRVQVAPRWLFPPFVAVFSPRGVRDV
MSMEG_0968|M.smegmatis_MC2_155 ALDMG-------QQVIRAAGG-AVTRVQFGPRWLVPPLVAVFSPEGIRDV
TH_3255|M.thermoresistible__bu SFHTG-------QELLRDAGG-PVK-------WAIPPIVLVTSPAGIRDV
Mvan_0245|M.vanbaalenii_PYR-1 TFHTG-------LETLRDAGG-PVTRLKLAPKWLMPPMVVATSPQGARDI
MUL_0604|M.ulcerans_Agy99 TLHVG-------SEALRDAGG-SVTRIWLGPKRLVPPMVMVTSPQGARDV
Mb1429c|M.bovis_AF2122/97 GFDAG-------DGFLGRLRGSDITRFRCAGRRFVS----ISHPDYVDHV
Rv1394c|M.tuberculosis_H37Rv GFDAG-------DGFLGRLRGSDITRFRCAGRRFVS----ISHPDYVDHV
MAB_1426|M.abscessus_ATCC_1997 RLALGAVWSTYRHTISEYLADLPGQDDVIVARAPMRKAVIVRNPELARHV
MMAR_0281|M.marinum_M -------------NPLSFLLSLPARGDLVRIRIGPATAVVACTAELTHEI
MAV_5160|M.avium_104 GFAVS-------RRTMMRRLSRRYGNVFTLRLPMWGPVVMVSDPQLAKQI
MLBr_02088|M.leprae_Br4923 DPGTR------ADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHP
.
Mflv_0056|M.gilvum_PYR-GCK LGRNDAFSER----CIVHEEVRDMAGDSLFVLPNE-PWRPRKRALQPVFT
MSMEG_0968|M.smegmatis_MC2_155 LGRNDAFAER----CIVHDEVRHAAGDSLFVLPNE-QWRPRKRALQPVFT
TH_3255|M.thermoresistible__bu LNRRDALSER----CQVHHEVRHLGGDSLFVLPTD-PWRARRRALAPVFT
Mvan_0245|M.vanbaalenii_PYR-1 LARGGGHIDK----TRVHHEMRRLLGANLFDLTHE-PWLPRRRALQPIFT
MUL_0604|M.ulcerans_Agy99 LGRSGALSDRGT--LPLLKDLRRAIGESVLNLPHD-TWLPRRRTLQPIFT
Mb1429c|M.bovis_AF2122/97 LHEARLKYVK----SDEYGPIRATAGLNLLTDEGD-SWARHRGALNSTFA
Rv1394c|M.tuberculosis_H37Rv LHEARLKYVK----SDEYGPIRATAGLNLLTDEGD-SWARHRGALNSTFA
MAB_1426|M.abscessus_ATCC_1997 LVANQDNYIK----SAEYDLLAVGFGRGLVTDLNEGLWNRNRRLVQPIFA
MMAR_0281|M.marinum_M LCDDRIFDKG----GIFFDRFREMLGDGLGTCPRS-QHRRQRRLLQPAFH
MAV_5160|M.avium_104 FTTSPDELGN------IQPNLSRLFGSGSVFGLEGDDHRRRRRLLAPPFH
MLBr_02088|M.leprae_Br4923 LSASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFA
: . : : *
Mflv_0056|M.gilvum_PYR-GCK PQNVRRFGGHMSRAAEVFVDAWR------DGGDVDLDLECRRITMQSLGR
MSMEG_0968|M.smegmatis_MC2_155 KHSVRAFGGHMSRAAQTLVDEWADQWAQADSLEVDLDAVCRRVTMQSLGR
TH_3255|M.thermoresistible__bu PTAVRSYGGYMSEAAQRVADGWQ------AAREVDLDAECRRLTMRSLGR
Mvan_0245|M.vanbaalenii_PYR-1 KQHVREFAGHMATAAQTVADSWA------DGTELDLDTECRKLTLRALGR
MUL_0604|M.ulcerans_Agy99 KQRVAGFAGHMSEAANHILLGWP------DGAEVDLNAASHALVLRVVGH
Mb1429c|M.bovis_AF2122/97 RRHLRGLVGLMIDPIADVTAALVP------GAQFDMHQSMVETTLRVVAN
Rv1394c|M.tuberculosis_H37Rv RRHLRGLVGLMIDPIADVTAARVP------GAQFDMHQSMVETTLRVVAN
MAB_1426|M.abscessus_ATCC_1997 KRQVDLFAPQMAEAAARTISRWDELYAE--GKPVDITAEMNYLTMDIVAQ
MMAR_0281|M.marinum_M TQRLPGYAQTMTTEVAATVGRWQN------GQIIDVPAEMMAITGRTLLA
MAV_5160|M.avium_104 GKSMKNYESIIEEETLRETAGWPE------GESFPTLPPMMRITLNAILR
MLBr_02088|M.leprae_Br4923 PKVVQALEGDIAALVDSLLDKGAA------AGQFDVIADLAFPLAVAVIC
: : . . :
Mflv_0056|M.gilvum_PYR-GCK SVLGVDLNESADVIAEHMH----------------VASSYTADRALRP--
MSMEG_0968|M.smegmatis_MC2_155 SVLGIDLNERADVIVEHMH----------------VASSYATDRALRP--
TH_3255|M.thermoresistible__bu SVLGLDINERADAISEPMH----------------IASSYTADRALRP--
Mvan_0245|M.vanbaalenii_PYR-1 SVLGLDLDEHSDAIAEPLR----------------TALEYIADRALQP--
MUL_0604|M.ulcerans_Agy99 SVFGLDLQDKADVITTGVT----------------LAAKWAADRSARP--
Mb1429c|M.bovis_AF2122/97 ALFSQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWC--
Rv1394c|M.tuberculosis_H37Rv ALFSQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWC--
MAB_1426|M.abscessus_ATCC_1997 TMFGIDLSGDMAERMRIYFARLLKLFGVGFIVGAAPPLRWVVDKLAAHGP
MMAR_0281|M.marinum_M TMFSNSLPNPALRQALDDLT---------------AIFAVLYWRMLTP--
MAV_5160|M.avium_104 AVFGAEGAELDELRRLIPP-----------------WVTLGSRLAALP--
MLBr_02088|M.leprae_Br4923 RLLGVPYEDAPEFG----------------------RVSALLVQSVDP--
::.
Mflv_0056|M.gilvum_PYR-GCK -----------VRAPRWLPTPARRRAAHAVAEMRQVAADMLQVCRDD-PD
MSMEG_0968|M.smegmatis_MC2_155 -----------LRAPRWLPTPARRRARAAVAAMRAVTAEILQACRDD-AD
TH_3255|M.thermoresistible__bu -----------VRAPRWLPTPARRRARAAVATMRRITDEMLQACRAD-PD
Mvan_0245|M.vanbaalenii_PYR-1 -----------ISAPRWLPTPARRRARAASSTLHKLADKILQACRTD-PT
MUL_0604|M.ulcerans_Agy99 -----------VRAPHWLPTPARPRARGAYDAMYKIAADMLAACRAD-PS
Mb1429c|M.bovis_AF2122/97 -----------IYSGVHLPPPLR-EMQEITLTLDRAINSVIDRRLAE-PT
Rv1394c|M.tuberculosis_H37Rv -----------IYSGVHLPPPLR-EMQEITLTLDRAINSVIDRRLAE-PT
MAB_1426|M.abscessus_ATCC_1997 DELSSHTPRLAIRALRIGASVAAPRTMKGLRWVERTIDQLIADHRSGRIA
MMAR_0281|M.marinum_M ------------PPLDRLPTVGNRRYHRASARLRHTIGSAVAGRRAAGVD
MAV_5160|M.avium_104 ------------KPQRYPRFGPWGQLDRWRRQYDGVIERLIAAEQADPNF
MLBr_02088|M.leprae_Br4923 -----------FITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT---
. . :
Mflv_0056|M.gilvum_PYR-GCK RDAPLVRALMDARDPETGMALSDDDICNDLLIFMLAGHDTTATALTYALW
MSMEG_0968|M.smegmatis_MC2_155 RDAPLVRALMAAEDPETGERLSDEDICNDLLIFMLAGHDTTATALTYALW
TH_3255|M.thermoresistible__bu RDAPLVHALIRATDPETGRGLSDEDICNDLLIFMLAGHDTTATALTYALW
Mvan_0245|M.vanbaalenii_PYR-1 RDAPLVQALIAASDPATGRPLSDDEIRDELIVFMLAGHDTTATTLTYAMW
MUL_0604|M.ulcerans_Agy99 REAPLITALIDATGPNTGESLSDQQICDEMVYFMILGEDTTSTVLTYALW
Mb1429c|M.bovis_AF2122/97 NSADLLNVLLSAD----GGIWPRQRVRDEALTFMLAGHETTANAMSWFWY
Rv1394c|M.tuberculosis_H37Rv NSADLLNVLLSAD----GGIWPRQRVRDEALTFMLAGHETTANAMSWFWY
MAB_1426|M.abscessus_ATCC_1997 RQDNLLALLMAAEDPETGAKYTDLEIRDELMTFLGAGFETTAAALAWTWY
MMAR_0281|M.marinum_M RGDLLSAILASHEVDSSTVAFTDTEVIDQIVSFFIAGTETTALTVAWALY
MAV_5160|M.avium_104 AERTDVLALLLRSTYDDGAAMSHKEIGDELLTLLAAGHETTASTLAWAFE
MLBr_02088|M.leprae_Br4923 PGEDLISRLIELD--ESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVL
* . : :: * :** ::
Mflv_0056|M.gilvum_PYR-GCK VLGHHPDVQDRVAAEAA-ALGRRELEPGDVPHLKYTTQVLLEALRLCPPA
MSMEG_0968|M.smegmatis_MC2_155 ALGHHPEIQDRVAAEAR-ALGDRELTPADVPQLGYTVQVLHESLRMCPPA
TH_3255|M.thermoresistible__bu ALGHHPEIQDRVAAEVA-ELPDREITPHDVPRLGYTVQVLRESLRLCPPA
Mvan_0245|M.vanbaalenii_PYR-1 ALGHHHDVQDRVRAEVV-GIGDRELTPEDVPALGYTIQVLHEALRLCPPA
MUL_0604|M.ulcerans_Agy99 ALGQHCQLQDRLAAEAA-ELGDRPLTPADVPRLGYTIQVLQEAMRLRPPG
Mb1429c|M.bovis_AF2122/97 LMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRYFSSV
Rv1394c|M.tuberculosis_H37Rv LMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRYFSSV
MAB_1426|M.abscessus_ATCC_1997 LLSRNPDARAKLGQEVDRVLGGRQPTAADVDNLPWTAAVLNEAMRVYPPI
MMAR_0281|M.marinum_M LLAEHPAIEQRVHAEIDPVLAGRAATHADLPRLGLVNRIVTETLRLYPPG
MAV_5160|M.avium_104 RISRHPELLARLVEEAD--NGGNELRQAAILEVQRARTVIDFAGRHVYP-
MLBr_02088|M.leprae_Br4923 AMLRNPSQWKALSSNPQ-----------------RAPLVVEETLRYDPAI
: : : : . : : * .
Mflv_0056|M.gilvum_PYR-GCK AGVGRMAVRDIDVDGHRVQAGTLVAVGIYALHRDPEIWPDPDRFDPDRFS
MSMEG_0968|M.smegmatis_MC2_155 AGVGRLALRDIAVAGHRVEAGSLVALGIYAVHHDPQLWPDPEVFDPDRFS
TH_3255|M.thermoresistible__bu AGVGRLAMSDLAVDGYRVEAGTLLAVGIQAIHRDPSLWPDPMVFDPDRFA
Mvan_0245|M.vanbaalenii_PYR-1 AATARMAMRDVEVDGYRIEAGSMMAVGIYALHRDPALWERPLVFDPDRFS
MUL_0604|M.ulcerans_Agy99 PTVARRAMQDIEVDGYRVQAGTYCLVGVYAMHRDPALWDDPLAFDPDRFA
Mb1429c|M.bovis_AF2122/97 WIIAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFL
Rv1394c|M.tuberculosis_H37Rv WIIAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFL
MAB_1426|M.abscessus_ATCC_1997 LGLARTAKADDVLGDYPISAGTTVMVLIDSIHHNERVWDDAKTFDPARFL
MMAR_0281|M.marinum_M WIISRVATADVYLGGHRIPAGATVIFSPYLIHHRPDLYAEPERFDPDRWL
MAV_5160|M.avium_104 --------DVYRLGEWVIPRGYSIIVGIAQIHDNPDVFPDPRRFDPQRFI
MLBr_02088|M.leprae_Br4923 HLIGRVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPS
: : * . : : . *** *
Mflv_0056|M.gilvum_PYR-GCK PEQTAQRDRWHFLPFAGGARSCIGEHFARLETTLALATIVRSMRVTSSDN
MSMEG_0968|M.smegmatis_MC2_155 PENSRERDRWHFIPFAGGARACIGEHFARLETTLALATIIRSVVVGSVDA
TH_3255|M.thermoresistible__bu PERFKAMDRWQFVPFIGGPRSCIGEHFAMLESTLAIATLIRSVRIRSLDD
Mvan_0245|M.vanbaalenii_PYR-1 AQNSGGRDRWQYLPFGAGPRSCIGDHFAMLEATLALATIIRSAEIRSSDP
MUL_0604|M.ulcerans_Agy99 PKKSKGRDRWQYLPFGGGGRSCLGDHFAMLEASLALATIIREAEIHSLDG
Mb1429c|M.bovis_AF2122/97 RCPTD-RPRCAYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPG
Rv1394c|M.tuberculosis_H37Rv RCPTD-RPRCAYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPG
MAB_1426|M.abscessus_ATCC_1997 KENLQPEQRKAHMPFGAGKRMCVASGFANLEAIIGIAALAQNYELDLLPG
MMAR_0281|M.marinum_M PERARAIGRNTYIPFGGGARKCIGDNFGTTEAALALATIAANWRMQRLPG
MAV_5160|M.avium_104 DNKPS---ALSWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTIETTDA
MLBr_02088|M.leprae_Br4923 S---------RHLAFAVGSHFCLGAALARLEATVTLSAISARFPQVQLAG
:.* * : *:. :. * : :
Mflv_0056|M.gilvum_PYR-GCK D-FPVDVPFTTVAHGPIPAHLTPR-------------------
MSMEG_0968|M.smegmatis_MC2_155 E-FPVDVPFTTVAKGPIRANVAPRGPDHYTL------------
TH_3255|M.thermoresistible__bu D-FPVEVPFTTVARGPIRAVVSARR------------------
Mvan_0245|M.vanbaalenii_PYR-1 H-FPMIVPFTTVAAEPIRARVKSVNRIPAADSGGR--------
MUL_0604|M.ulcerans_Agy99 D-FPVAIPLPIVPAGPIRARVNQRRPSQEVCTTTLSDSSASS-
Mb1429c|M.bovis_AF2122/97 --YHVELEATLTLRPKHGVHVIGRRR-----------------
Rv1394c|M.tuberculosis_H37Rv --YHVELEATLTLRPKHGVHVIGRRR-----------------
MAB_1426|M.abscessus_ATCC_1997 QQPRREVTFTGGPEGEILMRLRKRHP-----------------
MMAR_0281|M.marinum_M LPVRPAVAASLRPRN-LALRVTARTADRVPGEPGRRLTSREIG
MAV_5160|M.avium_104 PDEPWHCRGVAFTPKHGGRIVVHRR------------------
MLBr_02088|M.leprae_Br4923 ---ELVYKPNVAMRGMSALPVQV--------------------
: