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AVIGKRRAYRVRVESATFLIVGGSSGIGRSVAERAARRGATVAVTARRTDRLASLAATIAEMGGSCSIHP ADATDPVAAQSVVADVLERHGKIDVVLLNAGGAPALDLTRLDAADITSVMDANYDVAVNYLVPVLRHMTE RGTGVIAHTNSLAGWYAVPLQGPYSAAKAALRVLFDAYRIEYAGSGVRFVSIYPGFVATEATEGDGMPAP GEISEQEAADHVLRALSSGRESYSFPRAMSTLVGLGRLLPTTLRRKVIKKVVTSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0030 | - | - | 100% (266) | shortchain dehydrogenase |
| M. marinum M | MMAR_2366 | - | 1e-23 | 34.92% (189) | fatty acyl-CoA reductase |
| M. marinum M | MMAR_0894 | - | 2e-21 | 33.78% (225) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1079 | - | 4e-21 | 35.23% (193) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4896 | - | 2e-24 | 34.01% (247) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1050 | - | 4e-21 | 35.23% (193) | oxidoreductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-18 | 26.52% (264) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2943c | - | 2e-22 | 32.13% (221) | putative oxidoreductase |
| M. avium 104 | MAV_3227 | - | 2e-24 | 34.36% (195) | oxidoreductase, short-chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_0269 | - | 2e-22 | 31.05% (219) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_2552 | - | 2e-20 | 33.33% (216) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0028 | - | 1e-119 | 97.32% (224) | shortchain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0944 | - | 4e-23 | 31.18% (263) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1079|M.bovis_AF2122/97 --------------------------------------------------
Rv1050|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
Mvan_0944|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK -----MRYVVTGGTGFIGSRLIGRLLARPDVTAVHVLVRRGSLGRFERLA
MAB_2943c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
TH_2552|M.thermoresistible__bu --------------------------------------------------
MSMEG_0269|M.smegmatis_MC2_155 --------------------------------------------------
Mb1079|M.bovis_AF2122/97 --------------------------------------------------
Rv1050|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
Mvan_0944|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK RDWDDRVHALVGDLTDPDLGLTDATVAELGPVDHVVHCAAIYDMTAPENR
MAB_2943c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
TH_2552|M.thermoresistible__bu --------------------------------------------------
MSMEG_0269|M.smegmatis_MC2_155 --------------------------------------------------
Mb1079|M.bovis_AF2122/97 --------------------------------------------------
Rv1050|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
Mvan_0944|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK QRAANVEGTRAVIALSRRLGATLHHVSSIAVAGTHPGVFTEDDVDVGQEL
MAB_2943c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
TH_2552|M.thermoresistible__bu --------------------------------------------------
MSMEG_0269|M.smegmatis_MC2_155 --------------------------------------------------
Mb1079|M.bovis_AF2122/97 --------------------------------------------MARQRF
Rv1050|M.tuberculosis_H37Rv --------------------------------------------MARQRF
MAV_3227|M.avium_104 MNLGDLTNLVEKPLAAVSN-------------------------------
Mvan_0944|M.vanbaalenii_PYR-1 MTS-------RNPLRRLAD-------------------------------
Mflv_4896|M.gilvum_PYR-GCK PTPYHRTKFEAEQLVRAADGLRFRIYRPAVVVGDSRTGEIDKIDGPYYFF
MAB_2943c|M.abscessus_ATCC_199 MRAVRHMIN-----------------------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
TH_2552|M.thermoresistible__bu --------------------------------------------------
MSMEG_0269|M.smegmatis_MC2_155 --------------------------------------------------
Mb1079|M.bovis_AF2122/97 R-------------------------------------------------
Rv1050|M.tuberculosis_H37Rv R-------------------------------------------------
MAV_3227|M.avium_104 -IINTPNSAGRYRPFYLRNL--------------------LDAVQGRTLE
Mvan_0944|M.vanbaalenii_PYR-1 -QVVLTS----MRPPILPAL--------------------LNRPNRETIE
Mflv_4896|M.gilvum_PYR-GCK GVLSALAALPRFTPMMLPDVGRTNLVPVDFVVDALDVLMHADGRDGQTFH
MAB_2943c|M.abscessus_ATCC_199 VFTKPIGVTYPWTPPLAERVH-----------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
TH_2552|M.thermoresistible__bu --------------------------------------------------
MSMEG_0269|M.smegmatis_MC2_155 --------------------------------------------------
Mb1079|M.bovis_AF2122/97 --------------------------------------------------
Rv1050|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3227|M.avium_104 EAV-----------------------------------------------
Mvan_0944|M.vanbaalenii_PYR-1 LK------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK LTAPKNTGLRGIYRGVARAAGLPPLVGVLPRAAAAPLLQVSGRAKAIRNM
MAB_2943c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAG-----------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MSMEG_0269|M.smegmatis_MC2_155 --------------------------------------------------
Mb1079|M.bovis_AF2122/97 --------------------------------------------------
Rv1050|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
Mvan_0944|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK AATQLGIPGEVLDVVELAPTFTSERTDEALCDSGISVPEFASYAPGLWRY
MAB_2943c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 --------------------------HFSPMSHPQVMAAAVHDLADLVDG
TH_2552|M.thermoresistible__bu --------------------------------------------------
MSMEG_0269|M.smegmatis_MC2_155 --------------------------------------------------
Mb1079|M.bovis_AF2122/97 --------------------DQVVLITGASSGIGEATAKAFAREGAVVAL
Rv1050|M.tuberculosis_H37Rv --------------------DQVVLITGASSGIGEATAKAFAREGAVVAL
MAV_3227|M.avium_104 -------------------DAKTVLITGASSGIGEAAAKKIAEAGGVVAL
Mvan_0944|M.vanbaalenii_PYR-1 --------------------GKRVLLTGASSGIGEAAAEKLARRGATVVA
Mflv_4896|M.gilvum_PYR-GCK WAEHLDPNRARQDDPAGPLVGRHVVITGASSGIGRASAVAVAARGATVFA
MAB_2943c|M.abscessus_ATCC_199 --------------------GRTVLVTGASSGIGRRLAERVAEAGGIVIV
MMAR_0030|M.marinum_M -----MAVIGKRRAYRVRVESATFLIVGGSSGIGRSVAERAARRGATVAV
MUL_0028|M.ulcerans_Agy99 -----------------------------------------------MAV
MLBr_00862|M.leprae_Br4923 KQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALARRGAEVVV
TH_2552|M.thermoresistible__bu -----------------VLSDSVALITGASGGIGRVLARRYAQRGARVAL
MSMEG_0269|M.smegmatis_MC2_155 --------------MFTSLEGRSAIVTGGSKGIGRGIAETFANAGVDVVI
:
Mb1079|M.bovis_AF2122/97 AARREGALRRVAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRID
Rv1050|M.tuberculosis_H37Rv AARREGALRRVAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRID
MAV_3227|M.avium_104 VARTRENLEKVASEIRENGGSAHVYPCDLSDMDAIAAMADRVLDDLGGVD
Mvan_0944|M.vanbaalenii_PYR-1 VARRGDLLDDLVARITDAGGRARAHACDLSDLDAIDALVATVEDELGGVD
Mflv_4896|M.gilvum_PYR-GCK LARNAEALDDLIAEIRESGGDAHAFTCDVTDPSAVEHTVKDILGRFGHVD
MAB_2943c|M.abscessus_ATCC_199 TGRRADELGEVVRGITARGGAAHALPGDLSTAAGADAVADAVLEGFGAPD
MMAR_0030|M.marinum_M TARRTDRLASLAATIAEMGGSCSIHPADATDPVAAQSVVADVLERHGKID
MUL_0028|M.ulcerans_Agy99 TARRTDRLASLAATIAEMGGSCSIHPADATNPVAAQSVVADVLERHGKID
MLBr_00862|M.leprae_Br4923 SDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVSAKHGVPD
TH_2552|M.thermoresistible__bu VARRRDELNVTAAAVTEAGGEALVLVADIRDETQCADAVAATVARWGRLD
MSMEG_0269|M.smegmatis_MC2_155 TGRNQDDLDRTVADLSGTRGKVTAVRADVTDPEDARRTVAETVSRHGGLD
: * * . * *
Mb1079|M.bovis_AF2122/97 VVFNNAGVSLVGPVDAETF-LDDTREMLEIDYLGTVRVVREVLPIMKQQR
Rv1050|M.tuberculosis_H37Rv VVFNNAGVSLVGPVDAETF-LDDTREMLEIDYLGTVRVVREVLPIMKQQR
MAV_3227|M.avium_104 ILINNAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRERG
Mvan_0944|M.vanbaalenii_PYR-1 ILVNNAGRSIRRPLEESLDRWHDVERTMTLNYYGPLRLIRGLAPGMLERG
Mflv_4896|M.gilvum_PYR-GCK YLVNNAGRSIRRSVTASTDRFHDYERVMAVNYFGAVRMVLALLPHWRERR
MAB_2943c|M.abscessus_ATCC_199 ILVLNAGRSIMRSVADSEYRLHDYERTVAINYLGGVGLVLRLLPGMRARG
MMAR_0030|M.marinum_M VVLLNAGG--APALDLTRLDAADITSVMDANYDVAVNYLVPVLRHMTERG
MUL_0028|M.ulcerans_Agy99 VVLLNAGG--APALDLTRLDAADITSVMDANYDVAVNYLVPVLRHMAERG
MLBr_00862|M.leprae_Br4923 IVVNNAGIGQAGRFLDTPP--EEFDRVLAVNLGGVVNCCRAFGQRLVERG
TH_2552|M.thermoresistible__bu VLVNNAAVP-GSDQSVAEATVDNWNQVLATNLVAPMVLSREALCQAMIPA
MSMEG_0269|M.smegmatis_MC2_155 IVCANAGIFPSGRLEDLTP--DDIEQVLGVNFKGTVYIVQAALQALTASG
: **. : : : :
Mb1079|M.bovis_AF2122/97 SG-RIMNMSSVVGRKAFA-RFAGYSSAMHAIAGFSDALRQELRGSGIAVS
Rv1050|M.tuberculosis_H37Rv SG-RIMNMSSVVGRKAFA-RFAGYSSAMHAIAGFSDALRQELRGSGIAVS
MAV_3227|M.avium_104 FG-QIINVSSVGVQTRAP-RFGAYIASKAALDSLCDALQAEVVNDNVKFT
Mvan_0944|M.vanbaalenii_PYR-1 DG-HVINVSTWGVKTESPPLFGVYNASKAALSSISRIMETEWADRGVHST
Mflv_4896|M.gilvum_PYR-GCK FG-HVVNVSSAGVQANNP-RYSAYIPSKAALDAFSEVVGAETLSDHITFT
MAB_2943c|M.abscessus_ATCC_199 SG-HIVHSSSIGVLGNLP-EFSAYVGSKAAMDAVLRIAGIESRADGVRVT
MMAR_0030|M.marinum_M TG-VIAHTNSLAGWYAVP-LQGPYSAAKAALRVLFDAYRIEYAGSGVRFV
MUL_0028|M.ulcerans_Agy99 TG-VIAHTNSLARWYAVP-LQGPYSAAKAALGVLFDAYRIEYAGSGVRFV
MLBr_00862|M.leprae_Br4923 TGGHIVNVSSMAAYAPLQ-SLSAYCTSKAATYMFSDCLRAELDAVGVGLT
TH_2552|M.thermoresistible__bu GSGNIQFLSSAAARNVAP-GKAHYAAAKLALSALGQTLALEVGGTGIRVN
MSMEG_0269|M.smegmatis_MC2_155 HGRVVVTSSITGPITGYP-GWSHYGASKAAQLGFLRTAAMELAPKKITIN
. : . . * : * . * :
Mb1079|M.bovis_AF2122/97 VIHPALTQTPLLANVDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARV
Rv1050|M.tuberculosis_H37Rv VIHPALTQTPLLANVDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARV
MAV_3227|M.avium_104 TVHMALVRTPMISPTTLYDKFP------ALTPEQAAGVIADAIVHRPRRA
Mvan_0944|M.vanbaalenii_PYR-1 TLYYPLVKTPMIAPTRAYDGLP------GLSAEEAAGWIITAARHRPVSI
Mflv_4896|M.gilvum_PYR-GCK NIHMPLVKTPMIAPSGRLNPAP------AISPEHAAAMVVRALVDKPARI
MAB_2943c|M.abscessus_ATCC_199 NVHLPLVSTDMIAPTD-WSEYA------SLTLDEGVDMVVGAIRRQSPEV
MMAR_0030|M.marinum_M SIYPGFVATEATEGDGMPAPGE-------ISEQEAADHVLRALSSGRESY
MUL_0028|M.ulcerans_Agy99 SIYPGFVATEATEGDGMPAPGE-------ISEQEAAEHVLRALSSGRESY
MLBr_00862|M.leprae_Br4923 TICPGVIDTNIIQSTRIDTPTAKQER--VRDRRGQLDMMFRLRRYGPDKV
TH_2552|M.thermoresistible__bu TLVVGSVEGELLDRYVARRAAADG-----VSPDEVLSGLARSTKLGRLIS
MSMEG_0269|M.smegmatis_MC2_155 AVLPGNIMTEGLDEMG----------------QDYLDQMASAIPAGRLGS
: :
Mb1079|M.bovis_AF2122/97 VVPFQPRLLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTE
Rv1050|M.tuberculosis_H37Rv VVPFQPRLLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTE
MAV_3227|M.avium_104 SSPFG---------QFAAVADAVNPAVMDRVRNRAFAMFGDSSAAKGDES
Mvan_0944|M.vanbaalenii_PYR-1 APRIA---------VTAHAINSIAPAAVDTIMKRQRMQPKD---------
Mflv_4896|M.gilvum_PYR-GCK DTPIG---------TVADLGMYLTPKLARRVLHQLYLGFPDSAAAQGIAE
MAB_2943c|M.abscessus_ATCC_199 NNPLG---------ILYRDAYRAVPGIVSRVQNDYYRWYSSRGQKAGAAP
MMAR_0030|M.marinum_M SFPRAMS-------TLVGLGRLLPTTLRRKVIKKVVTSA-----------
MUL_0028|M.ulcerans_Agy99 SFPRAMS-------TLVGLGRLFPTTLRRKVIKKVVTSA-----------
MLBr_00862|M.leprae_Br4923 ADTILSAIK-----KNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI-
TH_2552|M.thermoresistible__bu PEE------------VADVSLWLASDAASAITGQDIFVTGG---------
MSMEG_0269|M.smegmatis_MC2_155 VADIG------------NAALFFATDEAAYVTGQTLVVDGGQVLPESHLA
Mb1079|M.bovis_AF2122/97 SAKAQAAQPERGYSSAR--------------------------
Rv1050|M.tuberculosis_H37Rv SAKAQAAQPERGYSSAR--------------------------
MAV_3227|M.avium_104 AADATEFDARSET--------------------FVRATRGIHW
Mvan_0944|M.vanbaalenii_PYR-1 -------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK NDRVHSATRTPERKPWPPRRPVPSVRIPSAVKQAIRLVPGVHW
MAB_2943c|M.abscessus_ATCC_199 ASSPGIG------------------------------------
MMAR_0030|M.marinum_M -------------------------------------------
MUL_0028|M.ulcerans_Agy99 -------------------------------------------
MLBr_00862|M.leprae_Br4923 -------------------------------------------
TH_2552|M.thermoresistible__bu -------------------------------------------
MSMEG_0269|M.smegmatis_MC2_155 IAEL---------------------------------------