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RAVRHMINVFTKPIGVTYPWTPPLAERVHGRTVLVTGASSGIGRRLAERVAEAGGIVIVTGRRADELGEV VRGITARGGAAHALPGDLSTAAGADAVADAVLEGFGAPDILVLNAGRSIMRSVADSEYRLHDYERTVAIN YLGGVGLVLRLLPGMRARGSGHIVHSSSIGVLGNLPEFSAYVGSKAAMDAVLRIAGIESRADGVRVTNVH LPLVSTDMIAPTDWSEYASLTLDEGVDMVVGAIRRQSPEVNNPLGILYRDAYRAVPGIVSRVQNDYYRWY SSRGQKAGAAPASSPGIG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2943c | - | - | 100% (299) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3710 | - | 2e-47 | 40.30% (263) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3947 | - | 5e-41 | 39.92% (253) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1570 | - | 2e-52 | 41.11% (270) | fatty acyl-CoA reductase |
| M. gilvum PYR-GCK | Mflv_4896 | - | 2e-47 | 40.46% (262) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1543 | - | 2e-52 | 41.11% (270) | fatty acyl-CoA reductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 8e-18 | 36.79% (193) | short chain dehydrogenase |
| M. marinum M | MMAR_2366 | - | 3e-55 | 41.70% (271) | fatty acyl-CoA reductase |
| M. avium 104 | MAV_3227 | - | 3e-53 | 40.96% (271) | oxidoreductase, short-chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_1623 | - | 2e-50 | 41.67% (264) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3707 | - | 2e-24 | 35.51% (214) | PUTATIVE oxidoreductase, short-chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0918 | acrA1 | 4e-49 | 40.68% (263) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1527 | - | 1e-48 | 42.97% (249) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2366|M.marinum_M --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK MRYVVTGGTGFIGSRLIGRLLARPDVTAVHVLVRRGSLGRFERLARDWDD
Mvan_1527|M.vanbaalenii_PYR-1 ----------------MTRLLSDPGTAAVHVLVRRDSLGRFERLALNWDD
MSMEG_1623|M.smegmatis_MC2_155 MRYVVTGGTGFIGRRVVSEILVRDASAEVWVLVRRESLNRFEHLALDWGE
MUL_0918|M.ulcerans_Agy99 MRYVVTGGTGFIGRRVVSRLLQSDADARVWVLVRRQSLSRFERLATDWGD
MAB_2943c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 ------MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPD
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2366|M.marinum_M --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK RVHALVGDLTDPDLGLTDATVAELGPVDHVVHCAAIYDMTAPENRQRAAN
Mvan_1527|M.vanbaalenii_PYR-1 RVQPLVGELTVPGLGTSDVTVAELGRIDHVVHCAAVYDITAPEDRQRAAN
MSMEG_1623|M.smegmatis_MC2_155 RAKPLVGDLRADDLGLTGADVADLGDVTHVVHCAAIYDITVDEAAQRAAN
MUL_0918|M.ulcerans_Agy99 RVKPLVGEL--PELPVTEQISAELGQIDHVVHCAAVYDITAGEDQQRAAN
MAB_2943c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 SHVLWDGVVPLLAKRFRIVRYDNRG----VGQSSVPKPVSAYTMTRFADD
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2366|M.marinum_M --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK VEGTRAVIALSRRLGATLHHVSSIAVAGTHPGVFTEDDVDVGQELPTPYH
Mvan_1527|M.vanbaalenii_PYR-1 VDGTGAVVALSRRLGATLHHVSSIAVAGTYRGVFTEDDFDVAQDLPTPYH
MSMEG_1623|M.smegmatis_MC2_155 VDGTRAVIALARRLEATLHHVSSIAVAGNHRGVFTEDDFDVAQDLPTPYH
MUL_0918|M.ulcerans_Agy99 VDGTRAVIELTRRLDATLHHVSSIAVAGDFAGEYTEADFDVGQQLPSPYH
MAB_2943c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 FAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQ
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2366|M.marinum_M --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK RTKFEAEQLVRAADGLRFRIYRPAVVVGDSRTGEIDKIDGPYYFFGVLSA
Mvan_1527|M.vanbaalenii_PYR-1 RTKFEAELLVRSAEGLRFRIYRPAVVVGDSRTGEMDKIDGPYYFFGVLSA
MSMEG_1623|M.smegmatis_MC2_155 QTKFEAEMLVRATTDVPHRIYRPAVVVGDSRTGEMDKIDGPYYFFGVLAR
MUL_0918|M.ulcerans_Agy99 RTKFEAELLVRSSTGLRYRIYRPAVVVGDSRTGEMDKIDGLYYFFGVLAR
MAB_2943c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 -----DQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMV
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2366|M.marinum_M --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK LAALPRFTPMMLPDVGRTNLVPVDFVVDALDVLMHAD---GRDGQTFHLT
Mvan_1527|M.vanbaalenii_PYR-1 LAALPGFTPMLLPDVGRTNIVPVDFVVEAVAALMHVD---GRDGQTFHLT
MSMEG_1623|M.smegmatis_MC2_155 LAALPRFTPMALPDTGRTNVVPVDFVAKALVHLMHVE---GADGQTFHLT
MUL_0918|M.ulcerans_Agy99 LAALPSLTPILLPDTGRTNIVPVDYVVDALVALIHEDNMAFPNGRTFHLT
MAB_2943c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSG
Mb1570|M.bovis_AF2122/97 ---------------------------------------MNLGDLTNFVE
Rv1543|M.tuberculosis_H37Rv ---------------------------------------MNLGDLTNFVE
MMAR_2366|M.marinum_M ---------------------------------------MKLGDLTNLVE
MAV_3227|M.avium_104 ---------------------------------------MNLGDLTNLVE
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK APKNTGLRGIYRGVARAAGLPPLVGVLPRAAAAPLLQVSGRAKAIRNMAA
Mvan_1527|M.vanbaalenii_PYR-1 APKTTGLRGIYRGIAAAAGLPPLVGSLPRATAAPLLHVTGRAKVLRNMVA
MSMEG_1623|M.smegmatis_MC2_155 APNTVGLVDIYRGVAGAAGLPPLRAKLPRVTAAPVLDARGRARIVRNMVA
MUL_0918|M.ulcerans_Agy99 APQSVGLRGIYQAVTKEAGLPPARGVLPGSVVTPVLKARGRAKVLRNMAA
MAB_2943c|M.abscessus_ATCC_199 -----------------------------------------MRAVRHMIN
MLBr_00862|M.leprae_Br4923 RRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHF
Mb1570|M.bovis_AF2122/97 KPLAAVSNIVN---------------------------TPNSAGRYRPFY
Rv1543|M.tuberculosis_H37Rv KPLAAVSNIVN---------------------------TPNSAGRYRPFY
MMAR_2366|M.marinum_M KPFAAMSNIVN---------------------------TPNSAGRYRPFY
MAV_3227|M.avium_104 KPLAAVSNIIN---------------------------TPNSAGRYRPFY
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK TQLGIPGEVLDVVELAPTFTSERTDEALCDSGISVPEFASYAPGLWRYWA
Mvan_1527|M.vanbaalenii_PYR-1 TQLGIPAEILDIVELAPTFTSEHTDEALRGTGISVPEFASYAPALWRYWA
MSMEG_1623|M.smegmatis_MC2_155 TQLGIPGEVFDVAELRPTFTADNTDTALRGTGIAVPEFASYAPQLFRYWA
MUL_0918|M.ulcerans_Agy99 TQLGIPSEIFDVLDLKPTFISDETQKALRGSGVRLPDFAGYAPKLWRYWA
MAB_2943c|M.abscessus_ATCC_199 -----------------------------------------------VFT
MLBr_00862|M.leprae_Br4923 SPMSHPQVMAAA--------------------------VHDLADLVDGKQ
Mb1570|M.bovis_AF2122/97 LRNLLDAVQGRNLNDAVKGKVVLITGGSSGIGAAAAKKIAEAGGTVVLVA
Rv1543|M.tuberculosis_H37Rv LRNLLDAVQGRNLNDAVKGKVVLITGGSSGIGAAAAKKIAEAGGTVVLVA
MMAR_2366|M.marinum_M LRNLLDVVQGRKLSDAVEGKVVLITGGSSGIGEAAAHKIAEAGGTVVLVA
MAV_3227|M.avium_104 LRNLLDAVQGRTLEEAVDAKTVLITGASSGIGEAAAKKIAEAGGVVALVA
TH_3707|M.thermoresistible__bu VR-----ADGR---------------ADQGLDAARX--------------
Mflv_4896|M.gilvum_PYR-GCK EHLDPNRARQDDPAGPLVGRHVVITGASSGIGRASAVAVAARGATVFALA
Mvan_1527|M.vanbaalenii_PYR-1 QHLDPDRARRDDPAGPLVGKHVIITGASSGIGRAAAIAVAARGATVFALA
MSMEG_1623|M.smegmatis_MC2_155 EHLDPDRARRCDPAGPLVGRHVIITGASSGIGRASAIAVARRGAVVFALA
MUL_0918|M.ulcerans_Agy99 QHLDPDRALRDDPRGPLVGRHVIITGASSGIGRASALAVAQRGGCVFALA
MAB_2943c|M.abscessus_ATCC_199 KPIGVTYPWTPPLAERVHGRTVLVTGASSGIGRRLAERVAEAGGIVIVTG
MLBr_00862|M.leprae_Br4923 PSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALARRGAEVVVSD
...*:.
Mb1570|M.bovis_AF2122/97 RTLENLENVANDIRAIRGNGGTAHVYPCDLSDMDAIAVMADQVLGDLGGV
Rv1543|M.tuberculosis_H37Rv RTLENLENVANDIRAIRGNGGTAHVYPCDLSDMDAIAVMADQVLGDLGGV
MMAR_2366|M.marinum_M RTRENLEKVADDVRAG---GGAAHVYPCDLSDMDAIAAMADQVLADLGGV
MAV_3227|M.avium_104 RTRENLEKVASEIREN---GGSAHVYPCDLSDMDAIAAMADRVLDDLGGV
TH_3707|M.thermoresistible__bu -------------------GGTGRALACDLTDLDAIDELVLKIEQDLGGV
Mflv_4896|M.gilvum_PYR-GCK RNAEALDDLIAEIRES---GGDAHAFTCDVTDPSAVEHTVKDILGRFGHV
Mvan_1527|M.vanbaalenii_PYR-1 RNAEALDDLIAEIRAA---GGDAHAFTCDVTDSAAVEHTVKDILGRFDHV
MSMEG_1623|M.smegmatis_MC2_155 RNGEALDELIAEIRAD---GGQAHAFTCDVTDSASVEHTVKDILGRFDHV
MUL_0918|M.ulcerans_Agy99 RNADALDQLVAEIRAG---GGQAYAFTCDITDSTSVEHTVKDILGRFGHV
MAB_2943c|M.abscessus_ATCC_199 RRADELGEVVRGITAR---GGAAHALPGDLSTAAGADAVADAVLEGFGAP
MLBr_00862|M.leprae_Br4923 IDEAAAKNTAAQIVAS---GGVAYAYALDVSDAAAVEAFAEQVSAKHGVP
** . . . *:: . . : .
Mb1570|M.bovis_AF2122/97 DILINNAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRER
Rv1543|M.tuberculosis_H37Rv DILINNAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRER
MMAR_2366|M.marinum_M DILINNAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRER
MAV_3227|M.avium_104 DILINNAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRER
TH_3707|M.thermoresistible__bu DILINNAGKSIRRPLAESLERWHDVERTMNLNYYAPLRLIRGLAPGMRET
Mflv_4896|M.gilvum_PYR-GCK DYLVNNAGRSIRRSVTASTDRFHDYERVMAVNYFGAVRMVLALLPHWRER
Mvan_1527|M.vanbaalenii_PYR-1 DYLVNNAGRSIRRSVAASTDRLHDYERVMAVNYFGSVRMVLALLPHWRER
MSMEG_1623|M.smegmatis_MC2_155 DYLVNNAGRSIRRSVANSTDRLHDYERVMAVNYFGAVRMVLALLPHWRER
MUL_0918|M.ulcerans_Agy99 DYLVNNAGRSIRRSVVNSTDRLHDYERVMAVNYFGAVRMVLALLPHWRER
MAB_2943c|M.abscessus_ATCC_199 DILVLNAGRSIMRSVADSEYRLHDYERTVAINYLGGVGLVLRLLPGMRAR
MLBr_00862|M.leprae_Br4923 DIVVNNAGIGQAGRFLDTPP--EEFDRVLAVNLGGVVNCCRAFGQRLVER
* :: *** . . : .: :*.: :* . : :
Mb1570|M.bovis_AF2122/97 H-FGHIVNVSSVGVQTRAPRFGAYIASKAALDSLCDALQAETVHDNVRFT
Rv1543|M.tuberculosis_H37Rv H-FGHIVNVSSVGVQTRAPRFGAYIASKAALDSLCDALQAETVHDNVRFT
MMAR_2366|M.marinum_M G-FGHIINVSSVGVQTRAPRFGAYIASKAALDSLCDALQAETINEGVRFT
MAV_3227|M.avium_104 G-FGQIINVSSVGVQTRAPRFGAYIASKAALDSLCDALQAEVVNDNVKFT
TH_3707|M.thermoresistible__bu --WGVLSEAS--------PLFSVYNASKAALTAVSRVVETEWSQFGVHST
Mflv_4896|M.gilvum_PYR-GCK R-FGHVVNVSSAGVQANNPRYSAYIPSKAALDAFSEVVGAETLSDHITFT
Mvan_1527|M.vanbaalenii_PYR-1 R-FGHVVNVSSAGVQANNPRYSAYIPSKAALDAFAEVVGTETLSDHITFT
MSMEG_1623|M.smegmatis_MC2_155 R-FGHVVNVSSAGVQAHTPKYSAYLPSKAALDAFSDVVSTETLSDHITFT
MUL_0918|M.ulcerans_Agy99 R-FGHVVNVSSAGVQARNPKYSSYLPSKAALDAFADVVASETLSDHVTFT
MAB_2943c|M.abscessus_ATCC_199 G-SGHIVHSSSIGVLGNLPEFSAYVGSKAAMDAVLRIAGIESRADGVRVT
MLBr_00862|M.leprae_Br4923 GTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVGVGLT
* : . * . * **** . * : *
Mb1570|M.bovis_AF2122/97 TVHMALVRTPMISPTTIYDKFPTLTPDQAAGVITDAIVHRPRRASSPFGQ
Rv1543|M.tuberculosis_H37Rv TVHMALVRTPMISPTTIYDKFPTLTPDQAAGVITDAIVHRPRRASSPFGQ
MMAR_2366|M.marinum_M TVHMALVRTPMISPTTIYDKFPTLTPEQAAGVITDAIVHRPRRASSPFGQ
MAV_3227|M.avium_104 TVHMALVRTPMISPTTLYDKFPALTPEQAAGVIADAIVHRPRRASSPFGQ
TH_3707|M.thermoresistible__bu TLFYPLVKTPMIAPTREYDNLPALSAEEAADWMISAARYRPIQIAPRMAV
Mflv_4896|M.gilvum_PYR-GCK NIHMPLVKTPMIAPSGRLNPAPAISPEHAAAMVVRALVDKPARIDTPIGT
Mvan_1527|M.vanbaalenii_PYR-1 NIHMPLVRTPMIAPSGRLNPAPAISAEHAAAMVVRALVDKPARIDTPIGT
MSMEG_1623|M.smegmatis_MC2_155 NIHMPLVKTPMIAPSRRLNPVPPISAEHAAAMVVRALVEKPPRIDTPLGT
MUL_0918|M.ulcerans_Agy99 NIHMPLVATPMIVPSRRLNPTPAISAEHAAAMVVRGLVEKPARIDTPLGT
MAB_2943c|M.abscessus_ATCC_199 NVHLPLVSTDMIAPT-DWSEYASLTLDEGVDMVVGAIRRQSPEVNNPLGI
MLBr_00862|M.leprae_Br4923 TICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYGPDKVAD
.: :: * :* .: . . ..
Mb1570|M.bovis_AF2122/97 FAAVADAVNPAVMDRVRNRAFNMFGDSSAAKGSESQTDTSELDKRS----
Rv1543|M.tuberculosis_H37Rv FAAVADAVNPAVMDRVRNRAFNMFGDSSAAKGSESQTDTSELDKRS----
MMAR_2366|M.marinum_M FAAVADAVNPAVMDRVRNRAFGMFSDSSAAKGSESQSGTTELDKRS----
MAV_3227|M.avium_104 FAAVADAVNPAVMDRVRNRAFAMFGDSSAAKGDESAADATEFDARS----
TH_3707|M.thermoresistible__bu TARALNVVAPGVVNAVMKR-----------------------QRIQ----
Mflv_4896|M.gilvum_PYR-GCK VADLGMYLTPKLARRVLHQLYLGFPDSAAAQGIAENDRVHSATRTP---E
Mvan_1527|M.vanbaalenii_PYR-1 LADVGMYFTPKLARRVLHQLYLGFPDSAAARGITQ-DRSR-PRQAP---V
MSMEG_1623|M.smegmatis_MC2_155 FADFGNYLTPRVARRFLHQLYLGYPDSAAARGLAPAEPRPASTAGPGLPE
MUL_0918|M.ulcerans_Agy99 LAEIGNYVAPKLSRRILHQLYLGYPDSAAAQGISP--LNDAQEHRP---V
MAB_2943c|M.abscessus_ATCC_199 LYRDAYRAVPGIVSRVQNDYYRWYSSRG--------------QKAG----
MLBr_00862|M.leprae_Br4923 TILSAIKKN-KPIRPVAPEAYALYGIS---------------RVLP----
.
Mb1570|M.bovis_AF2122/97 -----------------------ETFVRATRGIHW-
Rv1543|M.tuberculosis_H37Rv -----------------------ETFVRATRGIHW-
MMAR_2366|M.marinum_M -----------------------ETFVQATRGIHW-
MAV_3227|M.avium_104 -----------------------ETFVRATRGIHW-
TH_3707|M.thermoresistible__bu -----------------------PVFV---------
Mflv_4896|M.gilvum_PYR-GCK RKPWPPRRPVPSVRIP----SAVKQAIRLVPGVHW-
Mvan_1527|M.vanbaalenii_PYR-1 RRPKRPSRPMPSVRVP----GPVKRAARLLPGLHW-
MSMEG_1623|M.smegmatis_MC2_155 RRPKRPARSRRGVRVPRAVGRPVKRAVRTLPGVHW-
MUL_0918|M.ulcerans_Agy99 RRPKRPALAVTGMRIP----RPVKRLVRLAPGVHW-
MAB_2943c|M.abscessus_ATCC_199 ------------------------AAPASSPGIG--
MLBr_00862|M.leprae_Br4923 ------------------------QVLRSTARIRVI