For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
AVTARRTDRLASLAATIAEMGGSCSIHPADATNPVAAQSVVADVLERHGKIDVVLLNAGGAPALDLTRLD AADITSVMDANYDVAVNYLVPVLRHMAERGTGVIAHTNSLARWYAVPLQGPYSAAKAALGVLFDAYRIEY AGSGVRFVSIYPGFVATEATEGDGMPAPGEISEQEAAEHVLRALSSGRESYSFPRAMSTLVGLGRLFPTT LRRKVIKKVVTSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0028 | - | - | 100% (224) | shortchain dehydrogenase |
| M. ulcerans Agy99 | MUL_4828 | - | 9e-14 | 30.53% (190) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0918 | acrA1 | 1e-13 | 28.12% (224) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0561c | - | 1e-13 | 31.96% (194) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4896 | - | 2e-16 | 30.36% (224) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2073c | - | 1e-13 | 27.52% (218) | shortchain dehydrogenase |
| M. leprae Br4923 | MLBr_00429 | - | 8e-12 | 31.29% (163) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3405 | - | 5e-15 | 26.91% (223) | short chain dehydrogenase |
| M. marinum M | MMAR_0030 | - | 1e-119 | 97.32% (224) | shortchain dehydrogenase |
| M. avium 104 | MAV_3227 | - | 1e-16 | 32.50% (160) | oxidoreductase, short-chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 1e-14 | 27.19% (228) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3128 | - | 2e-13 | 27.06% (218) | PUTATIVE short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5466 | - | 1e-14 | 30.27% (185) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
Mb0561c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK MRYVVTGGTGFIGSRLIGRLLARPDVTAVHVLVRRGSLGRFERLARDWDD
Rv2073c|M.tuberculosis_H37Rv --------------------------------------------------
TH_3128|M.thermoresistible__bu --------------------------------------------------
MLBr_00429|M.leprae_Br4923 --------------------------------------------------
MAB_3405|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5466|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
Mb0561c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK RVHALVGDLTDPDLGLTDATVAELGPVDHVVHCAAIYDMTAPENRQRAAN
Rv2073c|M.tuberculosis_H37Rv --------------------------------------------------
TH_3128|M.thermoresistible__bu --------------------------------------------------
MLBr_00429|M.leprae_Br4923 --------------------------------------------------
MAB_3405|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 ------MYTFVTSQDGTRIAVYQQGDPERPTLVMAHGWPDSHVLWDGVVG
Mvan_5466|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
Mb0561c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK VEGTRAVIALSRRLGATLHHVSSIAVAGTHPGVFTEDDVDVGQELPTPYH
Rv2073c|M.tuberculosis_H37Rv --------------------------------------------------
TH_3128|M.thermoresistible__bu --------------------------------------------------
MLBr_00429|M.leprae_Br4923 --------------------------------------------------
MAB_3405|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 ELGDRYRIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDAVSPDAPV
Mvan_5466|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
Mb0561c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK RTKFEAEQLVRAADGLRFRIYRPAVVVGDSRTGEIDKIDGPYYFFGVLSA
Rv2073c|M.tuberculosis_H37Rv --------------------------------------------------
TH_3128|M.thermoresistible__bu --------------------------------------------------
MLBr_00429|M.leprae_Br4923 --------------------------------------------------
MAB_3405|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 HVLAHDWGSVGIWEYLSRQGSAARMVSFTSVSGPSTDHYGAYVRRGLARP
Mvan_5466|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
Mb0561c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK LAALPRFTPMMLPDVGRTNLVPVDFVVDALDVLMHADGRDGQTFHLTAPK
Rv2073c|M.tuberculosis_H37Rv --------------------------------------------------
TH_3128|M.thermoresistible__bu --------------------------------------------------
MLBr_00429|M.leprae_Br4923 --------------------------------------------------
MAB_3405|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 YRPVQFARAVNLASRFSYWIPFSIPVLAPALMRRGAARRLQAIDTPGPKF
Mvan_5466|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0030|M.marinum_M --------------------------------------------------
Mb0561c|M.bovis_AF2122/97 --------------------------------------------MSKRPL
MAV_3227|M.avium_104 ------------------------------------MNLGDLTNLVEKPL
Mflv_4896|M.gilvum_PYR-GCK NTGLRGIYRGVARAAGLPPLVGVLPRAAAAPLLQVSGRAKAIRNMAATQL
Rv2073c|M.tuberculosis_H37Rv --------------------------------------------------
TH_3128|M.thermoresistible__bu --------------------------------------------------
MLBr_00429|M.leprae_Br4923 --------------------------------------------------
MAB_3405|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 QSENLDIDAANSLKIYRANAIRSFTHVRRDHYVQVPVQLICNRKDPVVRG
Mvan_5466|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0030|M.marinum_M ---MAVIGKRRAYR------------------------------------
Mb0561c|M.bovis_AF2122/97 RWLTEQITLAGMRP----------------------PISPQLLINRP-AM
MAV_3227|M.avium_104 AAVSNIINTPNSAG----------------------RYRPFYLRNLLDAV
Mflv_4896|M.gilvum_PYR-GCK GIPGEVLDVVELAPTFTSERTDEALCDSGISVPEFASYAPGLWRYWAEHL
Rv2073c|M.tuberculosis_H37Rv --------------------------------------------------
TH_3128|M.thermoresistible__bu --------------------------------------------------
MLBr_00429|M.leprae_Br4923 --------------------------------------------------
MAB_3405|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 EGYRDESKWVPLLWRRDLDAGHWAPFSHPRAIAQAVGEFVDHMEGAPPAR
Mvan_5466|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_0028|M.ulcerans_Agy99 ------------------------------------------MAVTARRT
MMAR_0030|M.marinum_M -----------VRVESATFLIVGGSSGIGRSVAERAARRGATVAVTARRT
Mb0561c|M.bovis_AF2122/97 QP---------VDLTGKRILLTGASSGIGAAATKQFGLHRAVVVAVARRK
MAV_3227|M.avium_104 QGRTL-----EEAVDAKTVLITGASSGIGEAAAKKIAEAGGVVALVARTR
Mflv_4896|M.gilvum_PYR-GCK DPNRARQDDPAGPLVGRHVVITGASSGIGRASAVAVAARGATVFALARNA
Rv2073c|M.tuberculosis_H37Rv ----------MDDTGAAPVVIFGGRSQIGGELARRLAAG-ATMVLAARNA
TH_3128|M.thermoresistible__bu ----------MKDTGG-LVVIFGGRSEIGAELAARLAPG-ATVLLAARRA
MLBr_00429|M.leprae_Br4923 -------MPIPAPSPEARAVVTGASQNIGEALATELAAHGHSLIVIARRE
MAB_3405|M.abscessus_ATCC_1997 ----------MDKITGKNIAITGAARGIGYATATALLRRGARVVIGDRDV
MSMEG_4280|M.smegmatis_MC2_155 ALRRAEVARPRKAFSDMLVSVTGAASGIGRATALEFARLGAEIVVSDIDE
Mvan_5466|M.vanbaalenii_PYR-1 --------MPYPTDNPATWFVTGASRGLGAELVRQLLRRGDNVAATTRSA
:
MUL_0028|M.ulcerans_Agy99 DRLASLAATIAEMGG-SCSIHPADATNPVAAQSVVADVLERHGKIDVVLL
MMAR_0030|M.marinum_M DRLASLAATIAEMGG-SCSIHPADATDPVAAQSVVADVLERHGKIDVVLL
Mb0561c|M.bovis_AF2122/97 DLLDAVADRITGDGG-TAMSLPCDLSDMEAIDALVEDVEKRIGGIDILIN
MAV_3227|M.avium_104 ENLEKVASEIRENGG-SAHVYPCDLSDMDAIAAMADRVLDDLGGVDILIN
Mflv_4896|M.gilvum_PYR-GCK EALDDLIAEIRESGG-DAHAFTCDVTDPSAVEHTVKDILGRFGHVDYLVN
Rv2073c|M.tuberculosis_H37Rv DQLADQAAALRAAGAIAVHTREFDADDLAAHGPLVASLVAEHGPIGTAVL
TH_3128|M.thermoresistible__bu DRLDDQVAAVAAAGAAAVHTREFDADDLDSHAPLVSGIVDEFGPIDTAVL
MLBr_00429|M.leprae_Br4923 DVLVDLAARLADKYRVAVEVRPADLTDPSERVKLADELTVRP--ISILCA
MAB_3405|M.abscessus_ATCC_1997 EALGSAVEGLKEEGN--VDAHPLDVTDPASFKRFLEAASAGG-PIDVLVN
MSMEG_4280|M.smegmatis_MC2_155 AGAKATATAIDEAGG-VAHAYGLDVADPDAVQRFVDDVCATHGVPDIVVN
Mvan_5466|M.vanbaalenii_PYR-1 ERLSAALAGVD-TGR--LLPLVVDLTDAAAVDGAVAAALDRFGRLDVVVN
: * : .
MUL_0028|M.ulcerans_Agy99 NAGG--APALDLTRLDAADITSVMDANYDVAVNYLVPVLRHMAERGTG-V
MMAR_0030|M.marinum_M NAGG--APALDLTRLDAADITSVMDANYDVAVNYLVPVLRHMTERGTG-V
Mb0561c|M.bovis_AF2122/97 NAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRGLAPGMLERGDG-H
MAV_3227|M.avium_104 NAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRERGFG-Q
Mflv_4896|M.gilvum_PYR-GCK NAGRSIRRSVTASTDRFHDYERVMAVNYFGAVRMVLALLPHWRERRFG-H
Rv2073c|M.tuberculosis_H37Rv AFGILGDQARAET--DAAHAVAIVHTDYVAQVSLLTHLAAAMRTAGRG-S
TH_3128|M.thermoresistible__bu AFGILGDQARAES--DPAHAVQIVHTDYVAQVSLLTVLADRMRAAGRG-R
MLBr_00429|M.leprae_Br4923 NAGT--ATFGPVSALDPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAG-G
MAB_3405|M.abscessus_ATCC_1997 NAGVMPIGPFLST--SDRAIRSMLEVNLYGVINGCQLALPEMVARRRG-Q
MSMEG_4280|M.smegmatis_MC2_155 NAGIGHAGNFLDT--PADQYERVLEVNFGGVVNCCRAFGRRLVEQGTGGH
Mvan_5466|M.vanbaalenii_PYR-1 NAGYGFLGAVEET--TDAEIRQMLDVQVSGVWNVLRSAVPHLRAARSG-H
* : : : *
MUL_0028|M.ulcerans_Agy99 IAHTNSLARWYAV-PLQGPYSAAKAALGVLFDAYRIEYAGSGVRFVSIYP
MMAR_0030|M.marinum_M IAHTNSLAGWYAV-PLQGPYSAAKAALRVLFDAYRIEYAGSGVRFVSIYP
Mb0561c|M.bovis_AF2122/97 IINVATWGVLSEASPLFSVYNASKAALSAVSRIIETEWGSQGVHSTTLYY
MAV_3227|M.avium_104 IINVSSVGVQTRA-PRFGAYIASKAALDSLCDALQAEVVNDNVKFTTVHM
Mflv_4896|M.gilvum_PYR-GCK VVNVSSAGVQANN-PRYSAYIPSKAALDAFSEVVGAETLSDHITFTNIHM
Rv2073c|M.tuberculosis_H37Rv LVVFSSVAGIRVR-RANYVYGSAKAGLDGFASGLADALHGTGVRLLIARP
TH_3128|M.thermoresistible__bu LVVFSSIAGARVR-RANYVYGSAKAGLDGFASGLADALHGTGVHLLIVRP
MLBr_00429|M.leprae_Br4923 ILISGSAAGNSPI-PYNATYAATKAFANTFSESLRGELHGSGVHVTLLAP
MAB_3405|M.abscessus_ATCC_1997 VVNIASVAGLMAV-PGMAVYNASKFGVVGLSRALSDEFAPQGVQVSAVLP
MSMEG_4280|M.smegmatis_MC2_155 IVNVASMAAYSPA-GSMNAYATSKAAVFMFSDCLRAELAHAGIGVTTLCP
Mvan_5466|M.vanbaalenii_PYR-1 IINVSSILGLTAV-PGWGLYCAGKFALNGMSEALAAELAGFGIRVTIVEP
: : * . * . :
MUL_0028|M.ulcerans_Agy99 GFVATEATEGDG------MPAPG-EISEQEAAEHVLRALSSG----RESY
MMAR_0030|M.marinum_M GFVATEATEGDG------MPAPG-EISEQEAADHVLRALSSG----RESY
Mb0561c|M.bovis_AF2122/97 PLVATPMIAPTK------AYDGLPALTAAEAAEWMVTAARTRP--VRIAP
MAV_3227|M.avium_104 ALVRTPMISPTT------LYDKFPALTPEQAAGVIADAIVHRP--RRASS
Mflv_4896|M.gilvum_PYR-GCK PLVKTPMIAPSG------RLNPAPAISPEHAAAMVVRALVDKP--ARIDT
Rv2073c|M.tuberculosis_H37Rv GFVIGRMTEG--------MTPAPLSVTPERVAAATARALVNG----KRVV
TH_3128|M.thermoresistible__bu GFVIGRMTEG--------MDPAPFASTPAQVANAAARALARG----RRAV
MLBr_00429|M.leprae_Br4923 GPVRTELPDHDEASLVEKLVPDFLWISTEHTARLSLDALERN----KMRV
MAB_3405|M.abscessus_ATCC_1997 TFTNTELIAGTD------STGAQKPVEPEDIAAAVVRIIEKP----RVQV
MSMEG_4280|M.smegmatis_MC2_155 GMIDTGIVDTTR--FDVPAHKAGQVEARRAQVKKTFQARRYGP--EKVAK
Mvan_5466|M.vanbaalenii_PYR-1 GYFRTDFLTTESLALPTAAGDAYPAIREMTEQHLQLQGSQLGDPVKGAAA
MUL_0028|M.ulcerans_Agy99 SFPRAMSTLVGLGRLFPTTLRRKVIKKVVTSA------------------
MMAR_0030|M.marinum_M SFPRAMSTLVGLGRLLPTTLRRKVIKKVVTSA------------------
Mb0561c|M.bovis_AF2122/97 RVAVAVNALDSIGPRWVNALMQRRNEQLNP--------------------
MAV_3227|M.avium_104 PFGQFAAVADAVNPAVMDRVRNRAFAMFGDSSAAKGDESAADATEFDARS
Mflv_4896|M.gilvum_PYR-GCK PIGTVADLGMYLTPKLARRVLHQLYLGFPDSAAAQGIAENDRVHSATRTP
Rv2073c|M.tuberculosis_H37Rv WIPWALRPMFVALRLLPRFVWRRMPR------------------------
TH_3128|M.thermoresistible__bu WVPRVIGPLAVTMRFVPRFVWRRMPR------------------------
MLBr_00429|M.leprae_Br4923 VPGLTSKAMSVASRYAPRAIVASIVGNFYKKLGGG---------------
MAB_3405|M.abscessus_ATCC_1997 TVPKPLGAVTTIVNSLPTGVRRFMSKKTGTDRVFLDFDTSARTAYENRAG
MSMEG_4280|M.smegmatis_MC2_155 AVTSAVSRNQALRPVTPEAYVAYGVSRLFPAALRRAARSQVL--------
Mvan_5466|M.vanbaalenii_PYR-1 VIHVAVTGGGPLHQLLGSDAVSYAEAKIDALVADVKAGRDLALTTDHR--
MUL_0028|M.ulcerans_Agy99 --------------------------------
MMAR_0030|M.marinum_M --------------------------------
Mb0561c|M.bovis_AF2122/97 --------------------------------
MAV_3227|M.avium_104 ET--------------------FVRATRGIHW
Mflv_4896|M.gilvum_PYR-GCK ERKPWPPRRPVPSVRIPSAVKQAIRLVPGVHW
Rv2073c|M.tuberculosis_H37Rv --------------------------------
TH_3128|M.thermoresistible__bu --------------------------------
MLBr_00429|M.leprae_Br4923 --------------------------------
MAB_3405|M.abscessus_ATCC_1997 SSLGVTKPDGE---------------------
MSMEG_4280|M.smegmatis_MC2_155 --------------------------------
Mvan_5466|M.vanbaalenii_PYR-1 --------------------------------