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MKLGDLTNLVEKPFAAMSNIVNTPNSAGRYRPFYLRNLLDVVQGRKLSDAVEGKVVLITGGSSGIGEAAA HKIAEAGGTVVLVARTRENLEKVADDVRAGGGAAHVYPCDLSDMDAIAAMADQVLADLGGVDILINNAGR SIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRERGFGHIINVSSVGVQTRAPRFGAYIASKAA LDSLCDALQAETINEGVRFTTVHMALVRTPMISPTTIYDKFPTLTPEQAAGVITDAIVHRPRRASSPFGQ FAAVADAVNPAVMDRVRNRAFGMFSDSSAAKGSESQSGTTELDKRSETFVQATRGIHW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2366 | - | - | 100% (338) | fatty acyl-CoA reductase |
| M. marinum M | MMAR_1153 | acrA1 | 2e-64 | 39.47% (304) | short-chain dehydrogenase, AcrA1 |
| M. marinum M | MMAR_0295 | - | 3e-59 | 46.13% (271) | short-chain type dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1570 | - | 1e-173 | 90.03% (341) | fatty acyl-CoA reductase |
| M. gilvum PYR-GCK | Mflv_4896 | - | 2e-64 | 45.38% (260) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1543 | - | 1e-173 | 90.03% (341) | fatty acyl-CoA reductase |
| M. leprae Br4923 | MLBr_01094 | - | 3e-23 | 30.68% (251) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3710 | - | 9e-69 | 44.83% (290) | short chain dehydrogenase |
| M. avium 104 | MAV_3227 | - | 1e-168 | 87.57% (338) | oxidoreductase, short-chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_1623 | - | 2e-63 | 41.99% (281) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3707 | - | 3e-35 | 41.95% (205) | PUTATIVE oxidoreductase, short-chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0918 | acrA1 | 3e-64 | 43.46% (260) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1527 | - | 4e-64 | 45.77% (260) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2366|M.marinum_M --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK MRYVVTGGTGFIGSRLIGRLLARPDVTAVHVLVRRGSLGRFERLARDWDD
Mvan_1527|M.vanbaalenii_PYR-1 ----------------MTRLLSDPGTAAVHVLVRRDSLGRFERLALNWDD
MSMEG_1623|M.smegmatis_MC2_155 MRYVVTGGTGFIGRRVVSEILVRDASAEVWVLVRRESLNRFEHLALDWGE
MUL_0918|M.ulcerans_Agy99 MRYVVTGGTGFIGRRVVSRLLQSDADARVWVLVRRQSLSRFERLATDWGD
MAB_3710|M.abscessus_ATCC_1997 MKYIVTGGTGFIGRRIVTRILETQPAAEVAILVRRESLSRFEKLAEQWDD
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2366|M.marinum_M --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK RVHALVGDLTDPDLGLTDATVAELGPVDHVVHCAAIYDMTAPENRQRAAN
Mvan_1527|M.vanbaalenii_PYR-1 RVQPLVGELTVPGLGTSDVTVAELGRIDHVVHCAAVYDITAPEDRQRAAN
MSMEG_1623|M.smegmatis_MC2_155 RAKPLVGDLRADDLGLTGADVADLGDVTHVVHCAAIYDITVDEAAQRAAN
MUL_0918|M.ulcerans_Agy99 RVKPLVGEL--PELPVTEQISAELGQIDHVVHCAAVYDITAGEDQQRAAN
MAB_3710|M.abscessus_ATCC_1997 RVQPLVGDLTQPDLGLPAE--GDPVTADHIVHCAAIYDITVDDKAQRAAN
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2366|M.marinum_M --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK VEGTRAVIALSRRLGATLHHVSSIAVAGTHPGVFTEDDVDVGQELPTPYH
Mvan_1527|M.vanbaalenii_PYR-1 VDGTGAVVALSRRLGATLHHVSSIAVAGTYRGVFTEDDFDVAQDLPTPYH
MSMEG_1623|M.smegmatis_MC2_155 VDGTRAVIALARRLEATLHHVSSIAVAGNHRGVFTEDDFDVAQDLPTPYH
MUL_0918|M.ulcerans_Agy99 VDGTRAVIELTRRLDATLHHVSSIAVAGDFAGEYTEADFDVGQQLPSPYH
MAB_3710|M.abscessus_ATCC_1997 VEGTRSVIALAKRTGAILHHISSIAVAGSYEGEFTEDDFDVNQDLPTPYH
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2366|M.marinum_M --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK RTKFEAEQLVRAADGLRFRIYRPAVVVGDSRTGEIDKIDGPYYFFGVLSA
Mvan_1527|M.vanbaalenii_PYR-1 RTKFEAELLVRSAEGLRFRIYRPAVVVGDSRTGEMDKIDGPYYFFGVLSA
MSMEG_1623|M.smegmatis_MC2_155 QTKFEAEMLVRATTDVPHRIYRPAVVVGDSRTGEMDKIDGPYYFFGVLAR
MUL_0918|M.ulcerans_Agy99 RTKFEAELLVRSSTGLRYRIYRPAVVVGDSRTGEMDKIDGLYYFFGVLAR
MAB_3710|M.abscessus_ATCC_1997 QTKFEAELLVRSEPGLRYRIYRPAVVVGDSRTGEMDKIDGPYYFFGVFAK
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2366|M.marinum_M --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK LAALPRFTPMMLPDVGRTNLVPVDFVVDALDVLMHAD---GRDGQTFHLT
Mvan_1527|M.vanbaalenii_PYR-1 LAALPGFTPMLLPDVGRTNIVPVDFVVEAVAALMHVD---GRDGQTFHLT
MSMEG_1623|M.smegmatis_MC2_155 LAALPRFTPMALPDTGRTNVVPVDFVAKALVHLMHVE---GADGQTFHLT
MUL_0918|M.ulcerans_Agy99 LAALPSLTPILLPDTGRTNIVPVDYVVDALVALIHEDNMAFPNGRTFHLT
MAB_3710|M.abscessus_ATCC_1997 LAKLPSFTPMMLPRAGRSNIVPVDYVVDATVELMHQE---GRDGQAFHLT
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2366|M.marinum_M --------------------------------------------------
MAV_3227|M.avium_104 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK APKNTGLRGIYRGVARAAGLPPLVGVLPRAAAAPLLQVSGRAKAIRNMAA
Mvan_1527|M.vanbaalenii_PYR-1 APKTTGLRGIYRGIAAAAGLPPLVGSLPRATAAPLLHVTGRAKVLRNMVA
MSMEG_1623|M.smegmatis_MC2_155 APNTVGLVDIYRGVAGAAGLPPLRAKLPRVTAAPVLDARGRARIVRNMVA
MUL_0918|M.ulcerans_Agy99 APQSVGLRGIYQAVTKEAGLPPARGVLPGSVVTPVLKARGRAKVLRNMAA
MAB_3710|M.abscessus_ATCC_1997 NPEVTYLRDIYSGIAAAAGLPPVRGSLPHAVATPFLRARGTLKVWRNMVV
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 MNLGDLTNFVEKPLAAVSNIVNTPNSAGR----------------YRPFY
Rv1543|M.tuberculosis_H37Rv MNLGDLTNFVEKPLAAVSNIVNTPNSAGR----------------YRPFY
MMAR_2366|M.marinum_M MKLGDLTNLVEKPFAAMSNIVNTPNSAGR----------------YRPFY
MAV_3227|M.avium_104 MNLGDLTNLVEKPLAAVSNIINTPNSAGR----------------YRPFY
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK TQLGIPGEVLDVVELAPTFTSERTDEALCDSGISVPEFASYAPGLWRYWA
Mvan_1527|M.vanbaalenii_PYR-1 TQLGIPAEILDIVELAPTFTSEHTDEALRGTGISVPEFASYAPALWRYWA
MSMEG_1623|M.smegmatis_MC2_155 TQLGIPGEVFDVAELRPTFTADNTDTALRGTGIAVPEFASYAPQLFRYWA
MUL_0918|M.ulcerans_Agy99 TQLGIPSEIFDVLDLKPTFISDETQKALRGSGVRLPDFAGYAPKLWRYWA
MAB_3710|M.abscessus_ATCC_1997 TQLGIPPEVIDITEIMPTFISESTQEALRPSGIKVPPFGSYAGRLYQYWR
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 LRNLLDAVQGRNLNDAVKGKVVLITGGSSGIGAAAAKKIAEAGGTVVLVA
Rv1543|M.tuberculosis_H37Rv LRNLLDAVQGRNLNDAVKGKVVLITGGSSGIGAAAAKKIAEAGGTVVLVA
MMAR_2366|M.marinum_M LRNLLDVVQGRKLSDAVEGKVVLITGGSSGIGEAAAHKIAEAGGTVVLVA
MAV_3227|M.avium_104 LRNLLDAVQGRTLEEAVDAKTVLITGASSGIGEAAAKKIAEAGGVVALVA
TH_3707|M.thermoresistible__bu VR-----ADGR---------------ADQGLDAARX--------------
Mflv_4896|M.gilvum_PYR-GCK EHLDPNRARQDDPAGPLVGRHVVITGASSGIGRASAVAVAARGATVFALA
Mvan_1527|M.vanbaalenii_PYR-1 QHLDPDRARRDDPAGPLVGKHVIITGASSGIGRAAAIAVAARGATVFALA
MSMEG_1623|M.smegmatis_MC2_155 EHLDPDRARRCDPAGPLVGRHVIITGASSGIGRASAIAVARRGAVVFALA
MUL_0918|M.ulcerans_Agy99 QHLDPDRALRDDPRGPLVGRHVIITGASSGIGRASALAVAQRGGCVFALA
MAB_3710|M.abscessus_ATCC_1997 RNLDPERYRRDDPAGPLVGRHVIITGASSGIGRAAAIAVARRGGTVFAVA
MLBr_01094|M.leprae_Br4923 -------------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISD
...*:. *
Mb1570|M.bovis_AF2122/97 RTLENLENVANDIRAIRGNGGTAHVYPCDLSDMDAIAVMADQVLGDLGGV
Rv1543|M.tuberculosis_H37Rv RTLENLENVANDIRAIRGNGGTAHVYPCDLSDMDAIAVMADQVLGDLGGV
MMAR_2366|M.marinum_M RTRENLEKVADDVRAG---GGAAHVYPCDLSDMDAIAAMADQVLADLGGV
MAV_3227|M.avium_104 RTRENLEKVASEIREN---GGSAHVYPCDLSDMDAIAAMADRVLDDLGGV
TH_3707|M.thermoresistible__bu -------------------GGTGRALACDLTDLDAIDELVLKIEQDLGGV
Mflv_4896|M.gilvum_PYR-GCK RNAEALDDLIAEIRES---GGDAHAFTCDVTDPSAVEHTVKDILGRFGHV
Mvan_1527|M.vanbaalenii_PYR-1 RNAEALDDLIAEIRAA---GGDAHAFTCDVTDSAAVEHTVKDILGRFDHV
MSMEG_1623|M.smegmatis_MC2_155 RNGEALDELIAEIRAD---GGQAHAFTCDVTDSASVEHTVKDILGRFDHV
MUL_0918|M.ulcerans_Agy99 RNADALDQLVAEIRAG---GGQAYAFTCDITDSTSVEHTVKDILGRFGHV
MAB_3710|M.abscessus_ATCC_1997 RDGEALDQLVAEIRED---GGKAHAFPCDLTDYAAVDDTVKSILGQFGHV
MLBr_01094|M.leprae_Br4923 VDGEGLAQTEGQLKAI---GASARTDRLDVTEREAFLTYADVVHENFGKV
*. . . *::: :. . : :. *
Mb1570|M.bovis_AF2122/97 DILINNAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRER
Rv1543|M.tuberculosis_H37Rv DILINNAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRER
MMAR_2366|M.marinum_M DILINNAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRER
MAV_3227|M.avium_104 DILINNAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRER
TH_3707|M.thermoresistible__bu DILINNAGKSIRRPLAESLERWHDVERTMNLNYYAPLRLIRGLAPGMRET
Mflv_4896|M.gilvum_PYR-GCK DYLVNNAGRSIRRSVTASTDRFHDYERVMAVNYFGAVRMVLALLPHWRER
Mvan_1527|M.vanbaalenii_PYR-1 DYLVNNAGRSIRRSVAASTDRLHDYERVMAVNYFGSVRMVLALLPHWRER
MSMEG_1623|M.smegmatis_MC2_155 DYLVNNAGRSIRRSVANSTDRLHDYERVMAVNYFGAVRMVLALLPHWRER
MUL_0918|M.ulcerans_Agy99 DYLVNNAGRSIRRSVVNSTDRLHDYERVMAVNYFGAVRMVLALLPHWRER
MAB_3710|M.abscessus_ATCC_1997 DYLVNNAGRSIRRSVVNTVDRFHDYERVMAINYFGAVRLVLALLPHWRER
MLBr_01094|M.leprae_Br4923 NQIYNNAGIAFTGDVEVS--HFKDIERVMDVDYWGVVNGTKAFLPYLISS
: : **** :: : : : :* :*.* ::* . :. : * .
Mb1570|M.bovis_AF2122/97 HFGHIVNVSSVGVQTRAPRFGAYIASKAALDSLCDALQAETVHDN--VRF
Rv1543|M.tuberculosis_H37Rv HFGHIVNVSSVGVQTRAPRFGAYIASKAALDSLCDALQAETVHDN--VRF
MMAR_2366|M.marinum_M GFGHIINVSSVGVQTRAPRFGAYIASKAALDSLCDALQAETINEG--VRF
MAV_3227|M.avium_104 GFGQIINVSSVGVQTRAPRFGAYIASKAALDSLCDALQAEVVNDN--VKF
TH_3707|M.thermoresistible__bu -WGVLSEAS--------PLFSVYNASKAALTAVSRVVETEWSQFG--VHS
Mflv_4896|M.gilvum_PYR-GCK RFGHVVNVSSAGVQANNPRYSAYIPSKAALDAFSEVVGAETLSDH--ITF
Mvan_1527|M.vanbaalenii_PYR-1 RFGHVVNVSSAGVQANNPRYSAYIPSKAALDAFAEVVGTETLSDH--ITF
MSMEG_1623|M.smegmatis_MC2_155 RFGHVVNVSSAGVQAHTPKYSAYLPSKAALDAFSDVVSTETLSDH--ITF
MUL_0918|M.ulcerans_Agy99 RFGHVVNVSSAGVQARNPKYSSYLPSKAALDAFADVVASETLSDH--VTF
MAB_3710|M.abscessus_ATCC_1997 KFGHVVNVSTAGVQTRNPKYASYIPTKAALDAFADVVATETVSDH--ITF
MLBr_01094|M.leprae_Br4923 GDGHVINISSVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNV
* : : * * . * .:* *: .. .: * :
Mb1570|M.bovis_AF2122/97 TTVHMALVRTPMISPTTIYDKFPTLTPDQAAGVITDAIVHRPRRASSPFG
Rv1543|M.tuberculosis_H37Rv TTVHMALVRTPMISPTTIYDKFPTLTPDQAAGVITDAIVHRPRRASSPFG
MMAR_2366|M.marinum_M TTVHMALVRTPMISPTTIYDKFPTLTPEQAAGVITDAIVHRPRRASSPFG
MAV_3227|M.avium_104 TTVHMALVRTPMISPTTLYDKFPALTPEQAAGVIADAIVHRPRRASSPFG
TH_3707|M.thermoresistible__bu TTLFYPLVKTPMIAPTREYDNLPALSAEEAADWMISAARYRPIQIAPRMA
Mflv_4896|M.gilvum_PYR-GCK TNIHMPLVKTPMIAPSGRLNPAPAISPEHAAAMVVRALVDKPARIDTPIG
Mvan_1527|M.vanbaalenii_PYR-1 TNIHMPLVRTPMIAPSGRLNPAPAISAEHAAAMVVRALVDKPARIDTPIG
MSMEG_1623|M.smegmatis_MC2_155 TNIHMPLVKTPMIAPSRRLNPVPPISAEHAAAMVVRALVEKPPRIDTPLG
MUL_0918|M.ulcerans_Agy99 TNIHMPLVATPMIVPSRRLNPTPAISAEHAAAMVVRGLVEKPARIDTPLG
MAB_3710|M.abscessus_ATCC_1997 TNIHMPLVKTPMITPSHKLNVVRGLTPEHAAAMVVRGLIEKPTRIDHPMG
MLBr_01094|M.leprae_Br4923 TTVYPGGIKTAIARNATAAEGLDVS--KIASRFDTWVAHTSPQHAARIIL
*.:. : *.: : : . *: * : :
Mb1570|M.bovis_AF2122/97 QFAAVADAVNPAVMDRVRNRAFNMFGDSSAAKGSESQTDTSELDKRSE--
Rv1543|M.tuberculosis_H37Rv QFAAVADAVNPAVMDRVRNRAFNMFGDSSAAKGSESQTDTSELDKRSE--
MMAR_2366|M.marinum_M QFAAVADAVNPAVMDRVRNRAFGMFSDSSAAKGSESQSGTTELDKRSE--
MAV_3227|M.avium_104 QFAAVADAVNPAVMDRVRNRAFAMFGDSSAAKGDESAADATEFDARSE--
TH_3707|M.thermoresistible__bu VTARALNVVAPGVVNAVMKR-----------------------QRIQP--
Mflv_4896|M.gilvum_PYR-GCK TVADLGMYLTPKLARRVLHQLYLGFPDSAAAQGIAENDRVHSATRTP---
Mvan_1527|M.vanbaalenii_PYR-1 TLADVGMYFTPKLARRVLHQLYLGFPDSAAARGITQ-DRSR-PRQAP---
MSMEG_1623|M.smegmatis_MC2_155 TFADFGNYLTPRVARRFLHQLYLGYPDSAAARGLAPAEPRPASTAGPGLP
MUL_0918|M.ulcerans_Agy99 TLAEIGNYVAPKLSRRILHQLYLGYPDSAAAQGISP--LNDAQEHRP---
MAB_3710|M.abscessus_ATCC_1997 TFADIGQYLTPKLSRRVLHQMYLAYPDSKAARGLEPVDDRRDLSTSR---
MLBr_01094|M.leprae_Br4923 KAVRKKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR---
. .
Mb1570|M.bovis_AF2122/97 ---------------------------TFVRATRGIHW
Rv1543|M.tuberculosis_H37Rv ---------------------------TFVRATRGIHW
MMAR_2366|M.marinum_M ---------------------------TFVQATRGIHW
MAV_3227|M.avium_104 ---------------------------TFVRATRGIHW
TH_3707|M.thermoresistible__bu ---------------------------VFV--------
Mflv_4896|M.gilvum_PYR-GCK ERKPWPPR--RPVPSVRIP----SAVKQAIRLVPGVHW
Mvan_1527|M.vanbaalenii_PYR-1 VRRPKRPS--RPMPSVRVP----GPVKRAARLLPGLHW
MSMEG_1623|M.smegmatis_MC2_155 ERRPKRPA--RSRRGVRVPRAVGRPVKRAVRTLPGVHW
MUL_0918|M.ulcerans_Agy99 VRRPKRPA--LAVTGMRIP----RPVKRLVRLAPGVHW
MAB_3710|M.abscessus_ATCC_1997 -RRPRAAKRVAAVSRLRVP----GPLMKAVRLIPGVHW
MLBr_01094|M.leprae_Br4923 --------------------------------------