For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TSRNPLRRLADQVVLTSMRPPILPALLNRPNRETIELKGKRVLLTGASSGIGEAAAEKLARRGATVVAVA RRGDLLDDLVARITDAGGRARAHACDLSDLDAIDALVATVEDELGGVDILVNNAGRSIRRPLEESLDRWH DVERTMTLNYYGPLRLIRGLAPGMLERGDGHVINVSTWGVKTESPPLFGVYNASKAALSSISRIMETEWA DRGVHSTTLYYPLVKTPMIAPTRAYDGLPGLSAEEAAGWIITAARHRPVSIAPRIAVTAHAINSIAPAAV DTIMKRQRMQPKD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0944 | - | - | 100% (294) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1527 | - | 8e-51 | 45.92% (233) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4623 | - | 1e-28 | 38.12% (202) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0561c | - | 1e-111 | 67.59% (290) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0026 | - | 1e-155 | 91.50% (294) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0547c | - | 1e-111 | 67.59% (290) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 2e-21 | 31.62% (234) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3947 | - | 2e-87 | 58.95% (285) | short chain dehydrogenase |
| M. marinum M | MMAR_0894 | - | 1e-115 | 69.62% (293) | dehydrogenase |
| M. avium 104 | MAV_4597 | - | 1e-116 | 70.45% (291) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1073 | - | 1e-115 | 68.38% (291) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3707 | - | 1e-81 | 70.24% (205) | PUTATIVE oxidoreductase, short-chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0647 | - | 1e-115 | 69.62% (293) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0561c|M.bovis_AF2122/97 --------------------------MSKRPL-RWLTEQITLAGMRP-PI
Rv0547c|M.tuberculosis_H37Rv --------------------------MSKRPL-RWLTEQITLAGMRP-PI
MMAR_0894|M.marinum_M --------------------------MSKSPL-RRLTEQITLAGMRP-PI
MUL_0647|M.ulcerans_Agy99 --------------------------MSKSPL-RRLTEQITLAGMRP-PI
MAV_4597|M.avium_104 --------------------------MSKSPL-RRFADQLVLATMRP-PM
Mvan_0944|M.vanbaalenii_PYR-1 -------------------------MTSRNPL-RRLADQVVLTSMRP-PI
Mflv_0026|M.gilvum_PYR-GCK MRSSRKSASEVLLECEFGAGNRLRGVTSRNPL-RRLADQVVLTSMRP-PI
MSMEG_1073|M.smegmatis_MC2_155 --------------------------MSKHPL-RRLTDNLFLASMRP-PV
TH_3707|M.thermoresistible__bu --------------------------------------------------
MAB_3947|M.abscessus_ATCC_1997 --------------------------MSKNSFGKRVSTTLARAAMQPFPS
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb0561c|M.bovis_AF2122/97 SPQLLINRPAMQPVDLTGKRILLTGASSGIGAAATKQFGLHRAVVVAVAR
Rv0547c|M.tuberculosis_H37Rv SPQLLINRPAMQPVDLTGKRILLTGASSGIGAAATKQFGLHRAVVVAVAR
MMAR_0894|M.marinum_M APQLLVNRPPIKPVALDGKRVMITGASSGIGEAAAEQFARQGATVIAVAR
MUL_0647|M.ulcerans_Agy99 APQLLVNRPPIKPVALDGKRVMITGASSGIGEAAAEQFARQGATVIAVAR
MAV_4597|M.avium_104 APQVLVNRPLIKPVELAGKRVLLTGASSGIGEAAAEQFAREGARVVVVAR
Mvan_0944|M.vanbaalenii_PYR-1 LPALLN-RPNRETIELKGKRVLLTGASSGIGEAAAEKLARRGATVVAVAR
Mflv_0026|M.gilvum_PYR-GCK LPALLN-RPTRETIELRGKRVLLTGASSGIGEAAAEKLARRGATVVAVAR
MSMEG_1073|M.smegmatis_MC2_155 TDQLIQLRAARDAVDLTGKRVLITGASSGIGAAAARKFAERGARVIVVAR
TH_3707|M.thermoresistible__bu -------------VRADGR------ADQGLDAARX---------------
MAB_3947|M.abscessus_ATCC_1997 LPLVRARLDPNYGAPIKGKRVLITGASSGIGEEAAYQFGKLGAKVIVVAR
MLBr_01094|M.leprae_Br4923 ------------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDV
*: *..*:.
Mb0561c|M.bovis_AF2122/97 RKDLLDAVADRITGDGGTAMSLPCDLSDMEAIDALVEDVEKRIGGIDILI
Rv0547c|M.tuberculosis_H37Rv RKDLLDAVADRITGDGGTAMSLPCDLSDMEAIDALVEDVEKRIGGIDILI
MMAR_0894|M.marinum_M RKDLLDAVADRITTSGGVAMSAPCDISDLDAVDALVADVENRLGGVDILI
MUL_0647|M.ulcerans_Agy99 RKDLLDAVADRITTSGGVAMSAPCDISDLDAVDALVADVENRLGGVDILI
MAV_4597|M.avium_104 RKDLLDALAEGITRAGGEAIAMPCDISDLDAADALVADVQQQLGGVDILI
Mvan_0944|M.vanbaalenii_PYR-1 RGDLLDDLVARITDAGGRARAHACDLSDLDAIDALVATVEDELGGVDILV
Mflv_0026|M.gilvum_PYR-GCK RQDLLDELVTRIADAGGDARAHACDLSDLDAVDELVATVEKDLGGIDILV
MSMEG_1073|M.smegmatis_MC2_155 RAELLDEVAGGITASGGDAKARPCDLTDLDAIDALVAEIESDHGGLDILV
TH_3707|M.thermoresistible__bu ---------------GGTGRALACDLTDLDAIDELVLKIEQDLGGVDILI
MAB_3947|M.abscessus_ATCC_1997 REDLLAEVAARIIAEGGEAEAIACDLSDLDAIDKLVETVNEKHGGVDILV
MLBr_01094|M.leprae_Br4923 DGEGLAQTEGQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIY
*. . : *::: :* . :.. * :: :
Mb0561c|M.bovis_AF2122/97 NNAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRGLAPGMLERGDGH
Rv0547c|M.tuberculosis_H37Rv NNAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRGLAPGMLERGDGH
MMAR_0894|M.marinum_M NNAGRSIRRPLAESLQRWHDVERTMVLNYYGPLRLIRGLAPGMLERGDGH
MUL_0647|M.ulcerans_Agy99 NNAGRSIRRPLAESLQRWHDVERTMVLNYYGPLRLIRGLAPGMLERGDGH
MAV_4597|M.avium_104 NNAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRGIAPGMIERGDGH
Mvan_0944|M.vanbaalenii_PYR-1 NNAGRSIRRPLEESLDRWHDVERTMTLNYYGPLRLIRGLAPGMLERGDGH
Mflv_0026|M.gilvum_PYR-GCK NNAGRSIRRPLEESLERWHDVERTMTLNYYGPLRLIRGLAPGMLARGDGH
MSMEG_1073|M.smegmatis_MC2_155 NNAGHSIRRPLADSLERWHDIERTMTLNYYSPLRLIRGFAPGMRERGAGH
TH_3707|M.thermoresistible__bu NNAGKSIRRPLAESLERWHDVERTMNLNYYAPLRLIRGLAPGMRE-----
MAB_3947|M.abscessus_ATCC_1997 NNAGRSIRRKTYESLDRWHDAERTMQLNYFSPLRLIRGFAPGMVERRSGH
MLBr_01094|M.leprae_Br4923 NNAGIAFTG--DVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGH
**** :: .:.:::* **.* ::*:. :. :.: * :
Mb0561c|M.bovis_AF2122/97 IINVA-TWGVLSEASPLFSVYNASKAALSAVSRIIETEWGSQG--VHSTT
Rv0547c|M.tuberculosis_H37Rv IINVA-TWGVLSEASPLFSVYNASKAALSAVSRIIETEWGSQG--VHSTT
MMAR_0894|M.marinum_M IINVT-TWGVLSEASPLFSVYNASKAALSAVSRTIETEWGRGG--VHSTT
MUL_0647|M.ulcerans_Agy99 IINVT-TWGVLSEASPLFSVYNASKAALSAVSRTIETEWGRGG--VHSTT
MAV_4597|M.avium_104 IINVS-TWGVLSEASPLFAVYNASKAALSTVSRVVETEWGDKG--VHSTT
Mvan_0944|M.vanbaalenii_PYR-1 VINVS-TWGVKTESPPLFGVYNASKAALSSISRIMETEWADRG--VHSTT
Mflv_0026|M.gilvum_PYR-GCK IINVS-TWGVKTESPPLFGVYNASKAALSSVSRIIETEWSGRG--VHATT
MSMEG_1073|M.smegmatis_MC2_155 IINVS-TWGVLSEASPLFSVYQASKAALSAVSRVIETEWGDGG--VHSTT
TH_3707|M.thermoresistible__bu ------TWGVLSEASPLFSVYNASKAALTAVSRVVETEWSQFG--VHSTT
MAB_3947|M.abscessus_ATCC_1997 IINVA-TWGVLTDVVPQFAVYNASKAALSTVSRIVDAEYGKYN--VHTTT
MLBr_01094|M.leprae_Br4923 VINISSVFGLFS--VPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTT
.:*: : * ..*:::* *: .:. : * . . *: **
Mb0561c|M.bovis_AF2122/97 LYYPLVATPMIAPTKAYDGLPA-LTAAEAAEWMVTAARTRPVRIAPRVAV
Rv0547c|M.tuberculosis_H37Rv LYYPLVATPMIAPTKAYDGLPA-LTAAEAAEWMVTAARTRPVRIAPRVAV
MMAR_0894|M.marinum_M LYYPLVATPMIAPTKAYSGMPA-LTPQEAAEWMITAARTRPVRIAPRIAL
MUL_0647|M.ulcerans_Agy99 LYYPLVATPMIAPTKAYSGMPA-LTPQEAAEWMITAARTRPVRIAPRIAL
MAV_4597|M.avium_104 LYYPLVATPMIAPTKAYQGVPA-LTPEEAGRWMITAARTRPVRIAPRMAI
Mvan_0944|M.vanbaalenii_PYR-1 LYYPLVKTPMIAPTRAYDGLPG-LSAEEAAGWIITAARHRPVSIAPRIAV
Mflv_0026|M.gilvum_PYR-GCK LYYPLVKTPMIAPTRAYDGLPG-LSADEAAGWIVTAARHRPVSIAPRIAV
MSMEG_1073|M.smegmatis_MC2_155 LYYPLVDTPMIKPTRAFDGLPA-LSADEAADWMITAARHRPVQIAPRVAV
TH_3707|M.thermoresistible__bu LFYPLVKTPMIAPTREYDNLPA-LSAEEAADWMISAARYRPIQIAPRMAV
MAB_3947|M.abscessus_ATCC_1997 LYFPLVRTPMIAPTEAYTNAAA-LTSAEAAEWMVLAARTRVVRIAPRISV
MLBr_01094|M.leprae_Br4923 VYPGGIKTAIARNATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVR
:: : *.: : . . . *: :: : * :
Mb0561c|M.bovis_AF2122/97 AVNALDSIGP--RWVNALMQRRNEQLNP---------------
Rv0547c|M.tuberculosis_H37Rv AVNALDSIGP--RWVNALMQRRNEQLNP---------------
MMAR_0894|M.marinum_M MAKALNTLGP--RWVNTLMQQRDDQLNDR--------------
MUL_0647|M.ulcerans_Agy99 MAKALNTLGP--RWVNTLMQQRDDQLNDR--------------
MAV_4597|M.avium_104 AAKALDTFGP--RWVNAVMQRQTVQPNREAGA-----------
Mvan_0944|M.vanbaalenii_PYR-1 TAHAINSIAP--AAVDTIMKRQRMQPKD---------------
Mflv_0026|M.gilvum_PYR-GCK TAHAINSVAP--GAVDTIMKRQRMQPRD---------------
MSMEG_1073|M.smegmatis_MC2_155 GARALNAVAP--GVVNAVMKRQSAQPDGVGRRPIFPAG-----
TH_3707|M.thermoresistible__bu TARALNVVAP--GVVNAVMKRQRIQP-------VFV-------
MAB_3947|M.abscessus_ATCC_1997 MSAATNAVAP--DLVTRVARNGRETLG----------------
MLBr_01094|M.leprae_Br4923 KKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR
* ..* . : :