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M. thermoresistible (build 8) TH_2459 (-)

annotation: mce-family protein mce1f
coordinates: 1107590 - 1109347
length: 586

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2459--100% (586)mce-family protein mce1f
M. thermoresistible (build 8)TH_2527-e-16256.11% (483) PUTATIVE virulence factor mce family protein
M. thermoresistible (build 8)TH_4161-e-16157.55% (497) PUTATIVE virulence factor mce family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3524cmce4F5e-9839.04% (561) MCE-family protein MCE4F
M. gilvum PYR-GCKMflv_2513-0.057.39% (589) virulence factor Mce family protein
M. tuberculosis H37RvRv3494cmce4F2e-9839.04% (561) MCE-family protein MCE4F
M. leprae Br4923MLBr_02594mce1F8e-7734.31% (510) putative secreted protein
M. abscessus ATCC 19977MAB_4148c-1e-10041.89% (456) MCE-family protein
M. marinum MMMAR_4705-0.055.31% (593) MCE-family protein
M. avium 104MAV_0953-0.055.35% (589) mce-family protein mce1f
M. smegmatis MC2 155MSMEG_4785-0.070.43% (585) mce-family protein mce1f
M. ulcerans Agy99MUL_4057mce4F2e-9638.38% (581) MCE-family protein Mce4F
M. vanbaalenii PYR-1Mvan_4145-0.057.22% (589) virulence factor Mce family protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb3524c|M.bovis_AF2122/97           MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSADFVAGG
Rv3494c|M.tuberculosis_H37Rv        MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSADFVAGG
MUL_4057|M.ulcerans_Agy99           MIDKLTKIQLSIFAIITVLTLTVMGIFYLRLPATFGIGTYEVSADFVAGG
MAB_4148c|M.abscessus_ATCC_199      -MERLIKIQLAIFAAVTVISVALMAIFYLRVPTALGIGKHDVKAQFVASG
TH_2459|M.thermoresistible__bu      MLTRFIRTQLILFTIAAIVGVSVMVFAYMQVPMLLGIGRMTVKIELPEAG
MSMEG_4785|M.smegmatis_MC2_155      MLTRFIRTQLIIFTIASIVGVAVMLFAYMQVPTLLGLGRITVTLQLPATG
Mflv_2513|M.gilvum_PYR-GCK          MLTRFVRNQLIIFTIASIVGVAVMIFSYMQVPTLLGIGRLAVTLELPASG
Mvan_4145|M.vanbaalenii_PYR-1       MLTRFVRNQLIIFTIASIVGVAVMLFAYMQVPTLLGVGRLVVTLELPESG
MMAR_4705|M.marinum_M               MLTRFVRIQLAIFAIVGMVGVAVMAVWYIQAPTLLGIGKMTVTLELPATG
MAV_0953|M.avium_104                MLTRFVRIQLAIFLIAGTIGVISMVLFYIQAPTLLGIGRMTVTLELPATG
MLBr_02594|M.leprae_Br4923          MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPSLVGIGRYSLKAELSATG
                                     :  : : ** :*     : :  : . *:: *  .*:*   :. ::   *

Mb3524c|M.bovis_AF2122/97           GLYKNANVTYRGVAVGRVESVGLNPNGVTAHMRLNSGTAIPSNVTATVRS
Rv3494c|M.tuberculosis_H37Rv        GLYKNANVTYRGVAVGRVESVGLNPNGVTAHMRLNSGTAIPSNVTATVRS
MUL_4057|M.ulcerans_Agy99           GLYKNANVTYRGVAVGRVESVGLNPNGVTAQMRLNSGTAIPSNVTATVKS
MAB_4148c|M.abscessus_ATCC_199      GLYQNANVTFRGVQIGRVTDVELTPEGVTATMRLNDNVKVPGNVVAAVKS
TH_2459|M.thermoresistible__bu      GLYRFSNVTYRGTQVGKVQSVTLTDDGVEATMSLVGSAKIPADLRAEVRS
MSMEG_4785|M.smegmatis_MC2_155      GLYQFSNVTYRGSQIGKVTAVELTETGAEATLSLDRSPKVPADLQAQVRS
Mflv_2513|M.gilvum_PYR-GCK          GLYRFSNVTYRGVQVGKVTEVNLTENGAEAILSLDTSPEIPADLRAEVRS
Mvan_4145|M.vanbaalenii_PYR-1       GLYRFSNVTYRGVQVGKVTGVSLTENGAEATLSLETSPKIPADLQAEVLS
MMAR_4705|M.marinum_M               GLYRFSNVTYRGVQIGKVTALGLTSSGAKATLALDASPKIPADLKAEVRS
MAV_0953|M.avium_104                GLYRFSNVTYRGVQLGKVTAVGLTPSGVKATLSLSTSPKVPADLTAEVLS
MLBr_02594|M.leprae_Br4923          GLYPTANVTYRGIAIGKVTDVEPTATGAEATMSIDSRYKIPIDSAANVHS
                                    ***  :***:**  :*:*  :  .  *. * : :     :* :  * * *

Mb3524c|M.bovis_AF2122/97           VSAIGEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQAETLL
Rv3494c|M.tuberculosis_H37Rv        VSAIGEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQAETLL
MUL_4057|M.ulcerans_Agy99           MSAIGEQYIDLVPPDDPSAGRLHDGSRIERNNTRIGQDVADLLHQAETLV
MAB_4148c|M.abscessus_ATCC_199      VSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQADGLV
TH_2459|M.thermoresistible__bu      MSAVGEQYIELLPRTD-SPPYLENGSVIPRSDTSVPQAVGPMLEQLSTLV
MSMEG_4785|M.smegmatis_MC2_155      MSAVGEQYVELLPRKD-SGPYLENGSVIPASETTIPQAVGPMLDQLSALV
Mflv_2513|M.gilvum_PYR-GCK          VSAVGEQYVELLPQTD-DGPFLEDGSRIPVSNTTIPQQVGPMLDQMSALV
Mvan_4145|M.vanbaalenii_PYR-1       VSAVGEQYVDLRPNTD-EGPYLEDGARIPVANTTVPQQVGPMLDQLSALV
MMAR_4705|M.marinum_M               ISAVGEYYVDLRPRTD-SPPYLHDGSVIARDRAVIGQPIGPVLDQTSALI
MAV_0953|M.avium_104                VSAVGEQYVDLRPRTN-SPPYLHDGSVIAMRDTKIPQPVGPMLDQVNALV
MLBr_02594|M.leprae_Br4923          VSAVGEQYLDLVSSGN-PGKYLAPGQTITKS--KIPIEIGPALDSVNRGL
                                    :**:** *::* .        *  *  *      :   :.  * . .  :

Mb3524c|M.bovis_AF2122/97           GSLGDTRLRELLHEAFIATNGAGPELARLIESARLLVDEANANYPQVSQL
Rv3494c|M.tuberculosis_H37Rv        GSLGDTRLRELLHEAFIATNGAGPELARLIESARLLVDEANANYPQVSQL
MUL_4057|M.ulcerans_Agy99           NSLGDTRLREVLHEAFVATNGSGPELARLVESARLLVDEANADYPQVSQL
MAB_4148c|M.abscessus_ATCC_199      NTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDSTTKL
TH_2459|M.thermoresistible__bu      NTIPKDSLSRLLDESFEAFNDTGYEFGSLLDSSATVTRDANAVADQTRLL
MSMEG_4785|M.smegmatis_MC2_155      DTIPKDKLSQLLDESYDAFNGTGFDFGSLLDSASTITTDASAVSDQTRAL
Mflv_2513|M.gilvum_PYR-GCK          GSLPKDRIPDLLDETFKAFNGAGPEFGSLLDSATTLAADMNGISEQTRAL
Mvan_4145|M.vanbaalenii_PYR-1       GSLPKDRIPDLLDETFKAFNGAGPDFGSMLDSAATLTNDVNGVSDQMRSL
MMAR_4705|M.marinum_M               NSIPKGKLSTLLDESFNAFNGAGYDFGSLFDSSAQLSGDLNGIADRTRTL
MAV_0953|M.avium_104                QSIPKTKLGQLLDESFQGFNGSGYDLGSLIDSSQTLSRDANGVVDRTRAL
MLBr_02594|M.leprae_Br4923          AALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITDVNDI
                                     :: .  :  :* *:  . .. *  :  :..*:  :    .        :

Mb3524c|M.bovis_AF2122/97           IDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAADPRLRDTLAGAPDAI
Rv3494c|M.tuberculosis_H37Rv        IDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAADPRLRDTLADAPDAI
MUL_4057|M.ulcerans_Agy99           IDQAGPFLQAQVRAGGDIKSLADGLARFTAELRQADPGLRNTLATAPDAI
MAB_4148c|M.abscessus_ATCC_199      IDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVAPGAS
TH_2459|M.thermoresistible__bu      AEDAEPFLDAQAQTTDSIRVWAASLAGITDQLDKNDPQIRTVLREGPGFA
MSMEG_4785|M.smegmatis_MC2_155      IDDSGPFLDAQAQTADSIRTWARSLAGITGTVSDDDAQIRTVLREGPGFA
Mflv_2513|M.gilvum_PYR-GCK          IDDSGPLLESQAETTDAIRTWARSLNGISAQVVQNDPQVRALLQQGPGFA
Mvan_4145|M.vanbaalenii_PYR-1       IDDSGPLIDSQAETADAIRTWAQSLNGISAQVVQNDPQVRALLQQGPAFA
MMAR_4705|M.marinum_M               TEDSGPFLDAQAQTTDSIRLWARSLAGVSGQLATNDPQIRTLLERGPGAF
MAV_0953|M.avium_104                TEDTGPLLDTQAQTTDSIRTWARSFAGISDVMVNNDSHFRTILEKGPETA
MLBr_02594|M.leprae_Br4923          IQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQAAPTA
                                     ::  *::::* .: . *.  . .:  .:      *  .:  *  ..   

Mb3524c|M.bovis_AF2122/97           DEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIEQLLVVFPALFAAII
Rv3494c|M.tuberculosis_H37Rv        DEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIEQLLVVFPALFAAII
MUL_4057|M.ulcerans_Agy99           DEANTAFSGIRPSFPALAANLANLGRVGVIYNKSIEQLLVVFPALFAAIT
MAB_4148c|M.abscessus_ATCC_199      EQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALFSALL
TH_2459|M.thermoresistible__bu      QETAQLLEQARPTLPVLLANMTTFGKIGVSYNPSIEQLLVLVPPFVAQIQ
MSMEG_4785|M.smegmatis_MC2_155      QETSRLLDGIKPTLPVLLANLTTIGQIAVTYNPSIEQLLVLLPPYVAQIQ
Mflv_2513|M.gilvum_PYR-GCK          QEVSSLLNQVKPTLPILLANMSTVGQTLLTYNPALEQLLVLFPGIIAAQQ
Mvan_4145|M.vanbaalenii_PYR-1       QEVSALLNQVKPTLPILLANLSTVGQTLLTYNPAIEQLLVLFPGIIAAQQ
MMAR_4705|M.marinum_M               NEASRLLDQIKPTLPVLLANLTTVGQIAVTYHASVEQILVLLPPFTAAIQ
MAV_0953|M.avium_104                NEASRLLDQIKPTLPVLLANLTTIGQIGITYHPSLEQLLVLLPSAVAIEQ
MLBr_02594|M.leprae_Br4923          DEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGASIAQ
                                    ::.   :   : ::*   *.:  .      *: .:** **..*   :   

Mb3524c|M.bovis_AF2122/97           TSAGGVPQDEG-AKLDFKIDLHDPPPCMTGFLPPPLVRSPADESVREIPR
Rv3494c|M.tuberculosis_H37Rv        TSAGGVPQDEG-AKLDFKIDLHDPPPCMTGFLPPPLVRSPADESVREIPR
MUL_4057|M.ulcerans_Agy99           TAAGGVPQDEG-AKLDFKVDLNDPPPCNVGFLPPPLIRSPADETLRELPP
MAB_4148c|M.abscessus_ATCC_199      TVAGGAPMDEG-AKLDFRLNLGDPPPCLTGFVPPPLMRTPADETLRELPR
TH_2459|M.thermoresistible__bu      TY-APTTSPNGLPNGEFSLGLGDPAACTVGFLPPSAWRSPADTTVVDTPE
MSMEG_4785|M.smegmatis_MC2_155      TY-TPTNSPAGLPNGEFSLGLGDPSSCTVGFLPPSAWRSPADESDMDTPD
Mflv_2513|M.gilvum_PYR-GCK          SFGLPQNSPTGLPTGDFALTISDPNPCTVGFLPSSQWRAPEDETTIDTPD
Mvan_4145|M.vanbaalenii_PYR-1       SFGLPQNSPTGLPMGDFALTISDPNPCTVGFLPSTQWRSPEDETTIDTPD
MMAR_4705|M.marinum_M               SF-LGTKSPVGLATGAFNLIISDPPACTVGFLPPSQWRNPADTTIVDTPD
MAV_0953|M.avium_104                AA-AAPNHPEGTAQGDFALTIDDPPICTVGFMPPNTWRSPDDLSDIDTPD
MLBr_02594|M.leprae_Br4923          TASATFP---NMAALDLALSINQPPPCLTGFIPAAEWRSPADTSLQPLPV
                                    :         . .   : : : :*  * .**:*.   * * * :    * 

Mb3524c|M.bovis_AF2122/97           DMYCKTAQNDPS-TVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGTNP
Rv3494c|M.tuberculosis_H37Rv        DMYCKTAQNDPS-TVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGTNP
MUL_4057|M.ulcerans_Agy99           DMYCKVAQNDAT-TVRGARNYPCQEFPGKRAPTIQLCRDPKGYFPVGRNP
MAB_4148c|M.abscessus_ATCC_199      DMYCKTAQNDPS-AVRGARNYPCQEFPGKRAPTIQLCRDPRGYVPIGSNP
TH_2459|M.thermoresistible__bu      GLYCKLPQDSPV-AVRGARNYPCMEHPGKRAPTVELCNDPEGYKPVATRQ
MSMEG_4785|M.smegmatis_MC2_155      NLYCKLPQDSPV-AVRGARNYPCMAHPGKRAPTVELCNDPNGYQPLAQRQ
Mflv_2513|M.gilvum_PYR-GCK          GLYCKLPQDSPM-NVRGARNYPCLEHPGKRAPTVELCNDPRGFVPMAIRQ
Mvan_4145|M.vanbaalenii_PYR-1       GLYCKLPQDSPM-NVRGARNYPCIEHPGKRAPTVELCNDPRGFVPTAIRN
MMAR_4705|M.marinum_M               GLYCKLPQDSPI-GVRGARNYPCMGQPGKRAPTVEICESDQPFEPLAMRQ
MAV_0953|M.avium_104                GLYCKLPQDSPL-SVRGARNYPCMGHPGKRAPTVEICNSDQPFMPLAMKQ
MLBr_02594|M.leprae_Br4923          GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSKPYVPLGTNP
                                    . *** . : .   ***:** **   *****.: . *.. . : * . . 

Mb3524c|M.bovis_AF2122/97           WRGPPIPYGTEVTDG------------RNILPPNKFPYIPPGADPDPGVP
Rv3494c|M.tuberculosis_H37Rv        WRGPPIPYGTEVTDG------------RNILPPNKFPYIPPGADPDPGVP
MUL_4057|M.ulcerans_Agy99           WRGPPVPYDTPVTDG------------LNVLPPNKFPYIPPDSDPDPGTP
MAB_4148c|M.abscessus_ATCC_199      WRGPPAPYDTPVEDP------------RNILPPNKFPNIPPGAEPDPGTP
TH_2459|M.thermoresistible__bu      HALGPYPFDPNLVSQGVPIDARARLD-DNTFGPVEGTPLPPGVTAPPPRI
MSMEG_4785|M.smegmatis_MC2_155      HTLGPYPFDPNLIAQGVAPDSRVRPD-DKIFGPLQGSPLPPGVTAPPQGP
Mflv_2513|M.gilvum_PYR-GCK          HITGPYPFDPNLVAQGIPIDDRVSGD-ERIHAPVQGTPLPPGAQRAGTPP
Mvan_4145|M.vanbaalenii_PYR-1       HITGPYPFDPNLVSQGVPIDSTVEGP-DRIYLPPEGTPLPPGAVRAGTPP
MMAR_4705|M.marinum_M               HIFGTYPLDPNLIAQGIPPDDRANWNRERIFGPVEGTPLPPGVGP-----
MAV_0953|M.avium_104                HVLGPYPLDPNLLAQGVPPDDRVTVN-DRIFGPVEGTPLPPGAVPRGAPA
MLBr_02594|M.leprae_Br4923          WFGDPNQLLTCPAPG------------ARCDQPVKPGLVIPAPTVDNGLN
                                        .    .                  .   * :   : *         

Mb3524c|M.bovis_AF2122/97           IVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPPEPPQ
Rv3494c|M.tuberculosis_H37Rv        IVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPPEPPQ
MUL_4057|M.ulcerans_Agy99           IVGPPPPGVIPGPPPAPNQPAQPAPPPNDNGPPPPFTSWMPPDYPPQAPQ
MAB_4148c|M.abscessus_ATCC_199      TLPPPSP------------PAPEVPPAGGDVMP-----------------
TH_2459|M.thermoresistible__bu      PQAPSPPPNFAGTGPGALLPG-QPLYTEPPVSPPGPAQVTEPDIVPAPPA
MSMEG_4785|M.smegmatis_MC2_155      PPAPQPPPNFAGTNPGPMLPG-QPIYVDPPVPGQPPAPIRNPEIVPLPPA
Mflv_2513|M.gilvum_PYR-GCK          VSEPGTPP-FPVGPPGPPAPGVAPAPSQPLFVPPAPPAVLPPGQGPLLPN
Mvan_4145|M.vanbaalenii_PYR-1       VSEPGTPP-FPVGAPAPMVPG-APPPAQPPILPPAP---LLPGQGPLLPG
MMAR_4705|M.marinum_M               -PEETVMPPGPLG---PPSPMG-------------EVSPIAPIDVPS---
MAV_0953|M.avium_104                GPRGENPPPGSVGAAVPPVPSSGPPALAPMSRMSADLPPIAPLDVPTP-T
MLBr_02594|M.leprae_Br4923          PAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQP-----------------
                                                                                      

Mb3524c|M.bovis_AF2122/97           VPYPATIPPPPPPE--------------------GTGPPPGPAPGPQPQA
Rv3494c|M.tuberculosis_H37Rv        VPYPATIPPPPPPE--------------------GTGPPPGPAPGPQPQA
MUL_4057|M.ulcerans_Agy99           IPYPKTLPPPPPPV--------------------GVGP----EPGPQPQA
MAB_4148c|M.abscessus_ATCC_199      ---------------------------------------------VSAQS
TH_2459|M.thermoresistible__bu      QLPSATEVPVPPGVNPDDLHLPPGAVPVPGPGSGTVISPSSSSSARDG-G
MSMEG_4785|M.smegmatis_MC2_155      QLPQATEVPVPHG-----LTAPP---PATDPG-APVAAPSAFDGGKSS-G
Mflv_2513|M.gilvum_PYR-GCK          QA-----VPAPPG-------------------GAVPAAPSAFGGNASG-G
Mvan_4145|M.vanbaalenii_PYR-1       QA-----VPVAPAS------------------GAVPVAPSAFGSNDSG-V
MMAR_4705|M.marinum_M               -----TPPPAPSG--------------------APSAAPSGLGRAAARPG
MAV_0953|M.avium_104                ELPPPPPPPAPAAP-------------DQVDGAAPQAAPSAFAGKASKPA
MLBr_02594|M.leprae_Br4923          -------------------------------------------NTCVYTP
                                                                                      

Mb3524c|M.bovis_AF2122/97           SGPAYTIYDQLSGAFADPAGGTGIFAPGMTG--ASSAENWVDLMRDPRQL
Rv3494c|M.tuberculosis_H37Rv        SGPAYTIYDQLSGAFADPAGGTGIFAPGMTG--ASSAENWVDLMRDPRQL
MUL_4057|M.ulcerans_Agy99           SGPAYTTYDPLTGVFKDPAGGAGIFVGGISG--ASSAENWVDLMLAPRTM
MAB_4148c|M.abscessus_ATCC_199      GPMAARAYDPKNGVFLDANNQPSVYAPALDR--GTEAETWADLMLGPKPV
TH_2459|M.thermoresistible__bu      PTVAFARYNPRTGEYMASDGRLYRQSDLSS-----TPKSWQELMPT----
MSMEG_4785|M.smegmatis_MC2_155      PAVTVAKYNPRNGEYMGADGKLYRQANLVG-----NAKSWQDLMPS----
Mflv_2513|M.gilvum_PYR-GCK          PSVATAAYDPNTGQYLSPDGAMHQISNVTPG---GTPKSWKDLLPM----
Mvan_4145|M.vanbaalenii_PYR-1       PTVGTAQYNPQTGEYIAPDGSMNRVTNVASG---ANPKSWKDLLPM----
MMAR_4705|M.marinum_M               PSVAFAQYDPHTGSYVAPDGQVYRQTDLIIPDTPKAPRTWKDMLPT----
MAV_0953|M.avium_104                PSVVVAKYDPRTGRYVGPDGKLYQQSDLVT---PKAPKTWKDMLPT----
MLBr_02594|M.leprae_Br4923          SGPPSAVYSPQSGELVGPDGVAYAVENSTKT----GDDGWKEMLAPAG--
                                           *.  .*    . .                   * :::